Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Kentucky

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 4921 - 4950 of 18293

Full-Text Articles in Entire DC Network

Measuring User Satisfaction: Uk Libraries’ Libqual+ 2020 Results, Julene L. Jones Apr 2021

Measuring User Satisfaction: Uk Libraries’ Libqual+ 2020 Results, Julene L. Jones

Library Presentations

No abstract provided.


Functional Activation Of Newborn Neurons Following Alcohol-Induced Reactive Neurogenesis, Natalie N. Nawarawong, Chelsea G. Nickell, Deann M. Hopkins, James R. Pauly, Kimberly Nixon Apr 2021

Functional Activation Of Newborn Neurons Following Alcohol-Induced Reactive Neurogenesis, Natalie N. Nawarawong, Chelsea G. Nickell, Deann M. Hopkins, James R. Pauly, Kimberly Nixon

Pharmaceutical Sciences Faculty Publications

Abstinence after alcohol dependence leads to structural and functional recovery in many regions of the brain, especially the hippocampus. Significant increases in neural stem cell (NSC) proliferation and subsequent “reactive neurogenesis” coincides with structural recovery in hippocampal dentate gyrus (DG). However, whether these reactively born neurons are integrated appropriately into neural circuits remains unknown. Therefore, adult male rats were exposed to a binge model of alcohol dependence. On day 7 of abstinence, the peak of reactive NSC proliferation, rats were injected with bromodeoxyuridine (BrdU) to label dividing cells. After six weeks, rats underwent Morris Water Maze (MWM) training then were …


Gait And Balance Changes With Investigational Peripheral Nerve Cell Therapy During Deep Brain Stimulation In People With Parkinson’S Disease, Geetanjali Gera, Zain Guduru, Tritia R. Yamasaki, Julie A. Gurwell, Monica Chau, Anna Krotinger, Frederick A. Schmitt, John T. Slevin, Greg A. Gerhardt, Craig G. Van Horne, Jorge E. Quintero Apr 2021

Gait And Balance Changes With Investigational Peripheral Nerve Cell Therapy During Deep Brain Stimulation In People With Parkinson’S Disease, Geetanjali Gera, Zain Guduru, Tritia R. Yamasaki, Julie A. Gurwell, Monica Chau, Anna Krotinger, Frederick A. Schmitt, John T. Slevin, Greg A. Gerhardt, Craig G. Van Horne, Jorge E. Quintero

Physical Therapy Faculty Publications

Background: The efficacy of deep brain stimulation (DBS) and dopaminergic therapy is known to decrease over time. Hence, a new investigational approach combines implanting autologous injury-activated peripheral nerve grafts (APNG) at the time of bilateral DBS surgery to the globus pallidus interna. Objectives: In a study where APNG was unilaterally implanted into the substantia nigra, we explored the effects on clinical gait and balance assessments over two years in 14 individuals with Parkinson’s disease. Methods: Computerized gait and balance evaluations were performed without medication, and stimulation was in the off state for at least 12 h to best assess the …


Vitamin D Promotes Skeletal Muscle Regeneration And Mitochondrial Health, Christine M. Latham, Camille R. Brightwell, Alexander R. Keeble, Brooke D. Munson, Nicholas T. Thomas, Alyaa M. Zagzoog, Christopher S. Fry, Jean L. Fry Apr 2021

Vitamin D Promotes Skeletal Muscle Regeneration And Mitochondrial Health, Christine M. Latham, Camille R. Brightwell, Alexander R. Keeble, Brooke D. Munson, Nicholas T. Thomas, Alyaa M. Zagzoog, Christopher S. Fry, Jean L. Fry

Athletic Training and Clinical Nutrition Faculty Publications

Vitamin D is an essential nutrient for the maintenance of skeletal muscle and bone health. The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. Furthermore, mounting evidence suggests that vitamin D may play an important role during muscle damage and regeneration. Muscle damage is characterized by compromised muscle fiber architecture, disruption of contractile protein integrity, and mitochondrial dysfunction. Muscle regeneration is a complex process that involves restoration of mitochondrial function and activation of satellite cells (SC), the resident skeletal muscle stem cells. VDR expression is strongly upregulated …


Keap1 Is Required For Artesunate Anticancer Activity In Non-Small-Cell Lung Cancer, Kristen S. Hill, Anthony Mcdowell Jr., J. Robert Mccorkle, Erin Schuler, Sally R. Ellingson, Rina Plattner, Jill M. Kolesar Apr 2021

Keap1 Is Required For Artesunate Anticancer Activity In Non-Small-Cell Lung Cancer, Kristen S. Hill, Anthony Mcdowell Jr., J. Robert Mccorkle, Erin Schuler, Sally R. Ellingson, Rina Plattner, Jill M. Kolesar

Pathology and Laboratory Medicine Faculty Publications

Artesunate is the most common treatment for malaria throughout the world. Artesunate has anticancer activity likely through the induction of reactive oxygen species, the same mechanism of action utilized in Plasmodium falciparum infections. Components of the kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway, which regulates cellular response to oxidative stress, are mutated in approximately 30% of non-small-cell lung cancers (NSCLC); therefore, we tested the hypothesis that KEAP1 is required for artesunate sensitivity in NSCLC. Dose response assays identified A549 cells, which have a G333C-inactivating mutation in KEAP1, as resistant to artesunate, with an IC50 of …


Science And Mathematics Teacher Communities Of Practice: Social Influences On Discipline-Based Identity And Self-Efficacy Beliefs, Samuel J. Polizzi, Yicong Zhu, Joshua W. Reid, Brandon Ofem, Sara Salisbury, Michael Beeth, Gillian Roehrig, Margaret J. Mohr-Schroeder, Keith Sheppard, Gregory T. Rushton Apr 2021

Science And Mathematics Teacher Communities Of Practice: Social Influences On Discipline-Based Identity And Self-Efficacy Beliefs, Samuel J. Polizzi, Yicong Zhu, Joshua W. Reid, Brandon Ofem, Sara Salisbury, Michael Beeth, Gillian Roehrig, Margaret J. Mohr-Schroeder, Keith Sheppard, Gregory T. Rushton

Science, Technology, Engineering, and Mathematics (STEM) Education Faculty Publications

Background
Teacher communities of practice, identity, and self-efficacy have been proposed to influence positive teacher outcomes in retention, suggesting all three may be related constructs. Qualitative studies of communities of practice can be difficult to empirically link to identity and self-efficacy in larger samples. In this study, we operationalized teacher communities of practice as specific networks related to teaching content and/or pedagogy. This scalable approach allowed us to quantitatively describe communities of practice and explore statistical relationships with other teacher characteristics. We asked whether these community of practice networks were related to identity and self-efficacy, similar to other conceptualizations of …


Method For Designing Compounds And Compositions Useful For Targeting High Stoichiometric Complexes To Treat Conditions, Including Treatment Of Viruses, Bacteria, And Cancers Having Acquired Drug Resistance, Peixuan Guo, Dan Shu Apr 2021

Method For Designing Compounds And Compositions Useful For Targeting High Stoichiometric Complexes To Treat Conditions, Including Treatment Of Viruses, Bacteria, And Cancers Having Acquired Drug Resistance, Peixuan Guo, Dan Shu

Pharmaceutical Sciences Faculty Patents

A method is described for the identification o f multi-subunit biocomplex drug targets. The method includes identifying a target that performs a biological function, wherein the target comprises one or more subunits, wherein a minimum number of the one or more subunits is inactivated to inhibit the biological function. The method includes selecting a drug that binds specifically to each subunit of the one or more subunits with a target probability. The method describes a relationship between inhibition efficiency of the drug and total number of the one or more subunits using a binomial distribution, wherein the inhibition efficiency comprises …


Indices To Volumes 8 - 13, Journal Of Natural Resources & Environmental Law Apr 2021

Indices To Volumes 8 - 13, Journal Of Natural Resources & Environmental Law

Journal of Natural Resources & Environmental Law

No abstract provided.


Tax Consequences Of Environmental Cleanup Costs: The Uncertainty Continues, Lisa Stephenson Apr 2021

Tax Consequences Of Environmental Cleanup Costs: The Uncertainty Continues, Lisa Stephenson

Journal of Natural Resources & Environmental Law

No abstract provided.


How A City's Pilot Project Can Influence A State's Brownfields Program, Bonnie Biemer Apr 2021

How A City's Pilot Project Can Influence A State's Brownfields Program, Bonnie Biemer

Journal of Natural Resources & Environmental Law

No abstract provided.


Brownfield Initiatives And Environmental Justice: Second-Class Cleanups Or Market-Based Equity?, Kirsten H. Engel Apr 2021

Brownfield Initiatives And Environmental Justice: Second-Class Cleanups Or Market-Based Equity?, Kirsten H. Engel

Journal of Natural Resources & Environmental Law

No abstract provided.


England's Contaminated Land Act Of 1995: Perspectives On America's Approach To Hazardous Substance Cleanups And Evolving Principles Of International Law, Michael P. Healy Apr 2021

England's Contaminated Land Act Of 1995: Perspectives On America's Approach To Hazardous Substance Cleanups And Evolving Principles Of International Law, Michael P. Healy

Journal of Natural Resources & Environmental Law

No abstract provided.


Risk Assessment, Redevelopment, And Environmental Justice: Evaluating The Brownfields Bargain, John S. Applegate Apr 2021

Risk Assessment, Redevelopment, And Environmental Justice: Evaluating The Brownfields Bargain, John S. Applegate

Journal of Natural Resources & Environmental Law

No abstract provided.


Learning From Brownfields, Wendy E. Wagner Apr 2021

Learning From Brownfields, Wendy E. Wagner

Journal of Natural Resources & Environmental Law

No abstract provided.


Brownfields Are Becoming Places Of Opportunity, Carol M. Browner Apr 2021

Brownfields Are Becoming Places Of Opportunity, Carol M. Browner

Journal of Natural Resources & Environmental Law

No abstract provided.


Cercla Liability For Parent Corporations After United States V. Cordova Chemical Company Of Michigan: Who Pays For Past Wrongs?, Matthew Leveridge Apr 2021

Cercla Liability For Parent Corporations After United States V. Cordova Chemical Company Of Michigan: Who Pays For Past Wrongs?, Matthew Leveridge

Journal of Natural Resources & Environmental Law

No abstract provided.


Adults Only! Can We Zone Away The Evils Of Adult Businesses?, Sam R. Collins Apr 2021

Adults Only! Can We Zone Away The Evils Of Adult Businesses?, Sam R. Collins

Journal of Natural Resources & Environmental Law

No abstract provided.


Radical Restructuring Of Environmental Policy To Preserve Biodiversity In Southern Africa: Malawi At The Crossroads, Tracy Dobson Apr 2021

Radical Restructuring Of Environmental Policy To Preserve Biodiversity In Southern Africa: Malawi At The Crossroads, Tracy Dobson

Journal of Natural Resources & Environmental Law

No abstract provided.


Discovering And Enforcing A Human Right To Environmental Protection, Mélanne Andromecca Civic Apr 2021

Discovering And Enforcing A Human Right To Environmental Protection, Mélanne Andromecca Civic

Journal of Natural Resources & Environmental Law

No abstract provided.


Indices To Volumes 8 - 12, Journal Of Natural Resources & Environmental Law Apr 2021

Indices To Volumes 8 - 12, Journal Of Natural Resources & Environmental Law

Journal of Natural Resources & Environmental Law

No abstract provided.


Preserving The Citizen Suit Provision: Citizens For A Better Environment V. The Steel Company, Rebecca L. Justice Apr 2021

Preserving The Citizen Suit Provision: Citizens For A Better Environment V. The Steel Company, Rebecca L. Justice

Journal of Natural Resources & Environmental Law

No abstract provided.


How The Legal System Has Failed The Environmental Justice Movement, Karen Smith Apr 2021

How The Legal System Has Failed The Environmental Justice Movement, Karen Smith

Journal of Natural Resources & Environmental Law

No abstract provided.


Congress Should Exempt "Critical Habitat" Designation Under The Endangered Species Act From Compliance With The National Environmental Policy Act, Kurt Warmbier Apr 2021

Congress Should Exempt "Critical Habitat" Designation Under The Endangered Species Act From Compliance With The National Environmental Policy Act, Kurt Warmbier

Journal of Natural Resources & Environmental Law

No abstract provided.


Basic Brownfields, Becky L. Jacobs Apr 2021

Basic Brownfields, Becky L. Jacobs

Journal of Natural Resources & Environmental Law

No abstract provided.


Application Of The Audit Privilege To Occupational Safety And Health Audits: Lessons Learned From Environmental Audits, Margaret S. Lopez Apr 2021

Application Of The Audit Privilege To Occupational Safety And Health Audits: Lessons Learned From Environmental Audits, Margaret S. Lopez

Journal of Natural Resources & Environmental Law

No abstract provided.


Table Of Contents For Volume 12, Issue 2, Journal Of Natural Resources & Environmental Law Apr 2021

Table Of Contents For Volume 12, Issue 2, Journal Of Natural Resources & Environmental Law

Journal of Natural Resources & Environmental Law

No abstract provided.


Mountain States Legal Foundation V. Glickman: Disputes Over Timber Removal From National Forests, Elizabeth Monohan, Brian Wright Apr 2021

Mountain States Legal Foundation V. Glickman: Disputes Over Timber Removal From National Forests, Elizabeth Monohan, Brian Wright

Journal of Natural Resources & Environmental Law

No abstract provided.


Danger For The Endangered Species Act?: Catron County Board Of Commissioners, New Mexico V. United States Fish And Wildlife Service, Richard W. Bertelson Iii Apr 2021

Danger For The Endangered Species Act?: Catron County Board Of Commissioners, New Mexico V. United States Fish And Wildlife Service, Richard W. Bertelson Iii

Journal of Natural Resources & Environmental Law

No abstract provided.


Brownfield Legislation: A Viable Option For The Southeast, Leslie Goff-Sanders Apr 2021

Brownfield Legislation: A Viable Option For The Southeast, Leslie Goff-Sanders

Journal of Natural Resources & Environmental Law

No abstract provided.


In Defense Of Fifra Preemption Of Failure To Warn Claims, S. Douglas Fish Apr 2021

In Defense Of Fifra Preemption Of Failure To Warn Claims, S. Douglas Fish

Journal of Natural Resources & Environmental Law

No abstract provided.