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Age At First Alcohol Use And Weapon Carrying Among Adolescents: Findings From The 2019 Youth Risk Behavior Survey, Philip Baiden, Nusrat Jahan, Henry K. Onyeaka, Shawndaya Thrasher, Savarra Tadeo, Erin Findley

Social Work Graduate Research

Background
Although studies have investigated the association between alcohol use and violent behaviors such as weapon carrying, few studies have examined the association between age at first alcohol use and weapon-carrying among adolescents. The objective of this study was to investigate the association between age at first alcohol use and weapon carrying among adolescents.

Methods
Data for this study came from the 2019 Youth Risk Behavior Survey. An analytic sample of 13,442 adolescents aged 14–18 years old (51% female) was analyzed using binary logistic regression. The outcome variable investigated in this study was weapon carrying during the past 30 days, …

A Highly Predictive Microrna Panel For Determining Delayed Cerebral Vasospasm Risk Following Aneurysmal Subarachnoid Hemorrhage, Wang-Xia Wang, Joe E. Springer, Kevin Xie, David W. Fardo, Kevin W. Hatton

Sanders-Brown Center on Aging Faculty Publications

Approximately one-third of aneurysmal subarachnoid hemorrhage (aSAH) patients develop delayed cerebral vasospasm (DCV) 3–10 days after aneurysm rupture resulting in additional, permanent neurologic disability. Currently, no validated biomarker is available to determine the risk of DCV in aSAH patients. MicroRNAs (miRNAs) have been implicated in virtually all human diseases, including aSAH, and are found in extracellular biofluids including plasma and cerebrospinal fluid (CSF). We used a custom designed TaqMan Low Density Array miRNA panel to examine the levels of 47 selected brain and vasculature injury related miRNAs in CSF and plasma specimens collected from 31 patients with or without DCV …

A Screen Of Fda-Approved Drugs Identifies Inhibitors Of Protein Tyrosine Phosphatase 4a3 (Ptp4a3 Or Prl-3), Dylan R. Rivas, Mark Vincent C. Dela Cerna, Caroline N. Smith, Shilpa Sampathi, Blaine G. Patty, Donghan Lee, Jessica S. Blackburn

Molecular and Cellular Biochemistry Faculty Publications

Protein tyrosine phosphatase 4A3 (PTP4A3 or PRL-3) is highly expressed in a variety of cancers, where it promotes tumor cell migration and metastasis leading to poor prognosis. Despite its clinical significance, small molecule inhibitors of PRL-3 are lacking. Here, we screened 1443 FDA-approved drugs for their ability to inhibit the activity of the PRL phosphatase family. We identified five specific inhibitors for PRL-3 as well as one selective inhibitor of PRL-2. Additionally, we found nine drugs that broadly and significantly suppressed PRL activity. Two of these broad-spectrum PRL inhibitors, Salirasib and Candesartan, blocked PRL-3-induced migration in human embryonic kidney cells …

Forest Development Over A Twenty-Year Chronosequence Of Reforested Urban Sites, Kenton L. Sena, Zachary J. Hackworth, John M. Lhotka

Lewis Honors College Faculty Publications

Urbanization causes a variety of negative ecological impacts, impairing forests, streams, and other ecosystems. While urban forests are the subject of increasing research attention, planted urban forests are less well-understood than remnant forests; however, these systems may be distinct in terms of ecosystem structure and function. The current study investigates a chronosequence of reforested urban sites in Lexington, KY, USA, with a focus on overstory and understory woody plant community characteristics. Monitoring plots were established in each of the 20 sites; tree height, dbh, and species were surveyed for the overstory, and species and height were surveyed for the understory. …

Acute Inflammatory Profiles Differ With Sex And Age After Spinal Cord Injury, Andrew N. Stewart, John L. Lowe, Ethan P. Glaser, Caitlin A. Mott, Ryan K. Shahidehpour, Katelyn E. Mcfarlane, William M. Bailey, Bei Zhang, John C. Gensel

Physiology Faculty Publications

Background

Sex and age are emerging as influential variables that affect spinal cord injury (SCI) recovery. Despite a changing demographic towards older age at the time of SCI, the effects of sex or age on inflammation remain to be elucidated. This study determined the sex- and age-dependency of the innate immune response acutely after SCI.

Methods

Male and female mice of ages 4- and 14-month-old received T9 contusion SCI and the proportion of microglia, monocyte-derived macrophages (MDM), and neutrophils surrounding the lesion were determined at 3- and 7-day post-injury (DPI) using flow cytometry. Cell counts of microglia and MDMs were …

Myocarditis Concurrent With Sweet Syndrome: A Presentation Of Acute Myeloid Leukemia, Christopher G. Burkeen, David Pottinger, Chaitanya Iragavarapu, Reshma Ramlal, Gerhard C. Hildebrandt

Markey Cancer Center Faculty Publications

Acute myeloid leukemia (AML) is the most common acute leukemia in American adults and portends a poor prognosis if untreated. Commonly, AML presents with symptoms related to concurrent leukopenia, anemia, or thrombocytopenia; however, due to its ability to affect many organ systems in the body, AML can have a highly varied clinical presentation. One such presentation is myocarditis, which is a rarely reported manifestation of AML. Myocarditis can have a varied clinical picture and often requires exclusion of other causes of cardiac dysfunction. Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is another presentation of AML; however, it is …

Heterosis And Combining Ability Of Morphological And Forage Quality Predictors Of Silage Corn Incentral Valley Of Mexico, B. Alarcon‐Zuniga, A. Bata‐Valverde, A. Betanzos‐Betanzos, M. Meneses‐Mayo, M. Crosby‐Galvan

IGC Proceedings (1977-2023)

No abstract provided.

A Survey On Long-Range Wide-Area Network Technology Optimizations, Felipe S. Dantas Silva, Emidio P. Neto, Helder Oliveira, Denis Rosário, Eduardo Cerqueira, Cristiano Both, Sherali Zeadally, Augusto V. Neto

Information Science Faculty Publications

Long-Range Wide-Area Network (LoRaWAN) enables flexible long-range service communications with low power consumption which is suitable for many IoT applications. The densification of LoRaWAN, which is needed to meet a wide range of IoT networking requirements, poses further challenges. For instance, the deployment of gateways and IoT devices are widely deployed in urban areas, which leads to interference caused by concurrent transmissions on the same channel. In this context, it is crucial to understand aspects such as the coexistence of IoT devices and applications, resource allocation, Media Access Control (MAC) layer, network planning, and mobility support, that directly affect LoRaWAN’s …

Intracranial Vcam1 At Time Of Mechanical Thrombectomy Predicts Ischemic Stroke Severity, Benton Maglinger, Madison Sands, Jacqueline A. Frank, Christopher J. Mclouth, Amanda L. Trout, Jill M. Roberts, Stephen Grupke, Jadwiga Turchan-Cholewo, Ann M. Stowe, Justin F. Fraser, Keith R. Pennypacker

Behavioral Science Faculty Publications

BACKGROUND: Emergent large vessel occlusion (ELVO) strokes are devastating ischemic vascular events for which novel treatment options are needed. Using vascular cell adhesion molecule 1 (VCAM1) as a prototype, the objective of this study was to identify proteomic biomarkers and network signaling functions that are potential therapeutic targets for adjuvant treatment for mechanical thrombectomy.

METHODS: The blood and clot thrombectomy and collaboration (BACTRAC) study is a continually enrolling tissue bank and registry from stroke patients undergoing mechanical thrombectomy. Plasma proteins from intracranial (distal to clot) and systemic arterial blood (carotid) were analyzed by Olink Proteomics for N=42 subjects. Statistical …

Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-Β Associated Neurodegenerative Pathways And Glial Signatures In A Mouse Model Of Alzheimer’S Disease: A Targeted Transcriptome Analysis, Chao Ma, Jerry B. Hunt, Andrii Kovalenko, Huimin Liang, Maj-Linda B. Selenica, Michael B. Orr, Bei Zhang, John C. Gensel, David J. Feola, Marcia N. Gordon, Dave Morgan, Paula C. Bickford, Daniel C. Lee

Sanders-Brown Center on Aging Faculty Publications

Brain myeloid cells, include infiltrating macrophages and resident microglia, play an essential role in responding to and inducing neurodegenerative diseases, such as Alzheimer’s disease (AD). Genome-wide association studies (GWAS) implicate many AD casual and risk genes enriched in brain myeloid cells. Coordinated arginine metabolism through arginase 1 (Arg1) is critical for brain myeloid cells to perform biological functions, whereas dysregulated arginine metabolism disrupts them. Altered arginine metabolism is proposed as a new biomarker pathway for AD. We previously reported Arg1 deficiency in myeloid biased cells using lysozyme M (LysM) promoter-driven deletion worsened amyloidosis-related neuropathology and behavioral impairment. However, …

Indices To Volumes 8 - 16, Journal Of Natural Resources & Environmental Law

Journal of Natural Resources & Environmental Law

No abstract provided.

Trash In The Courtroom: The Problem Of Solid Waste Control Ordinances After Huish Detergents, Inc. V. Warren County, Benjamin D. Allen

Journal of Natural Resources & Environmental Law

No abstract provided.

Technological Trash: Should We Regulate The Disposal Of Cathode Ray Tubes In Waste Facilities?, Kenneth Clay Ratley

Journal of Natural Resources & Environmental Law

No abstract provided.

Sunshine Patriot Or Cold War Casualty?: An Examination Of Wrongful Exposure Suits Brought By Nuclear Complex Employees, Christopher S. Turner

Journal of Natural Resources & Environmental Law

No abstract provided.

The Wto And The Environment: The Shrimp Case That Created A New World Order, Laura Yavitz

Journal of Natural Resources & Environmental Law

No abstract provided.

Cleanup Of Contaminated Oyster Beds Under The Clean Water Act And Louisiana's Environmental And Water Quality Laws, Erinn W. Neyrey, M. Michelle Marney

Journal of Natural Resources & Environmental Law

No abstract provided.

Does The Future Of Product Liability Actions Change After Hawkins V. Leslie's Pool Mart, Inc.?, Lisa N. Hayden

Journal of Natural Resources & Environmental Law

No abstract provided.

Dancing Around The Issue Of Fifra Preemption: Does It Really Still Matter That The Supreme Court Has Not Made A Decision?, Sandra L. Feeley

Journal of Natural Resources & Environmental Law

No abstract provided.

A Work Place Surveillance: Who's Watching?, Mark E. Heath

Journal of Natural Resources & Environmental Law

No abstract provided.

Tmdls For Nonpoint Sources In Kentucky: The Potential Impact Of Pronsolino V. Marcus, Henry L. Stephens Jr., Monica Dias

Journal of Natural Resources & Environmental Law

No abstract provided.

Indices To Volumes 8 - 15, Journal Of Natural Resources & Environmental Law

Journal of Natural Resources & Environmental Law

No abstract provided.

Mootness And Attorneys' Fees Under The Clean Water Act In The Old Timer, Inc. V. Blackhawk-Central City Sanitation District, Wanda A. Dotson

Journal of Natural Resources & Environmental Law

No abstract provided.

Recent Developments In Surface Mining: An Examination Of Black Mountain And Bragg V. Robertson, Mickey Webster

Journal of Natural Resources & Environmental Law

No abstract provided.

Variation In Nutritional Values Of Shrub Forages In The Pastoral Zone Of Western Australia, B. E. Norton, F. F. M. Daly, Gaye Krebs, K. Dodds

IGC Proceedings (1977-2023)

No abstract provided.

Centralized Thermal Stress Oriented Dispatch Strategy For Paralleled Grid-Connected Inverters Considering Mission Profiles, Luocheng Wang, Tiefu Zhao, Jiangbiao He

Electrical and Computer Engineering Faculty Publications

One of the major failure causes in the power modules comes from the severe thermal stress in power semiconductor devices. Recently, some local control level methods have been developed to balance the power loss, dealing with the harsh mission profile, in order to reduce the thermal stress. However, there is not any specific system level strategy to leverage these local control level methods responding to the multiple inverters situation. Besides, the impacts of these methods on the thermal cycle and lifetime of the power modules in the long-term time scale have not been evaluated and compared yet. Hence, in this …

Ascriptive Characteristics And Perceptions Of Impropriety In The Rule Of Law: Race, Gender, And Public Assessments Of Whether Judges Can Be Impartial, Yoshikuni Ono, Michael A. Zilis

Political Science Faculty Publications

Perceptions of procedural fairness influence the legitimacy of the law and because procedures are mutable, reforming them can buttress support for the rule of law. Yet legal authorities have recently faced a distinct challenge: accusations of impropriety based on their ascriptive characteristics (e.g., gender, ethnicity). We study the effect of these traits in the context of the U.S. legal system, focusing on the conditions under which citizens perceive female and minority judges as exhibiting impropriety and how this compares with perceptions of their white and male counterparts. We find that Americans use a judge's race and gender to make inferences …

Medline Search Retrieval Issues: A Longitudinal Query Analysis Of Five Vendor Platforms, C. Sean Burns, Tyler Nix, Robert M. Shapiro Ii, Jeffrey T. Huber

Information Science Faculty Publications

This study compared the results of data collected from a longitudinal query analysis of the MEDLINE database hosted on multiple platforms that include PubMed, EBSCOHost, Ovid, ProQuest, and Web of Science. The goal was to identify variations among the search results on the platforms after controlling for search query syntax. We devised twenty-nine cases of search queries comprised of five semantically equivalent queries per case to search against the five MEDLINE database platforms. We ran our queries monthly for a year and collected search result count data to observe changes. We found that search results varied considerably depending on MEDLINE …

Perceived Psychosocial Impacts Of Legalized Same-Sex Marriage: A Scoping Review Of Sexual Minority Adults' Experiences, Laurie A. Drabble, Angie R. Wootton, Cindy B. Veldhuis, Ellen D. B. Riggle, Sharon S. Rostosky, Pamela J. Lannutti, Kimberly F. Balsam, Tonda L. Hughes

Political Science Faculty Publications

A growing body of literature provides important insights into the meaning and impact of the right to marry a same-sex partner among sexual minority people. We conducted a scoping review to 1) identify and describe the psychosocial impacts of equal marriage rights among sexual minority adults, and 2) explore sexual minority women (SMW) perceptions of equal marriage rights and whether psychosocial impacts differ by sex. Using Arksey and O'Malley's framework we reviewed peer-reviewed English-language publications from 2000 through 2019. We searched six databases (PubMed, PsycINFO, CINAHL, Web of Science, JSTOR, and Sociological Abstracts) to identify English language, peer-reviewed journal articles …

Measuring The Impact Of The Affordable Care Act Medicaid Expansion On Access To Primary Care Using An Interrupted Time Series Approach, Elizabeth A. Brown, Brandi M. White, Walter J. Jones, Mulugeta Gebregziabher, Kit N. Simpson

Health and Clinical Sciences Faculty Publications

BACKGROUND: The Patient Protection and Affordable Care Act of 2010, commonly referred to as the Affordable Care Act (ACA), was created to increase access to primary care, improve quality of care, and decrease healthcare costs. A key provision in the law that mandated expansion of state Medicaid programme changed when states were given the option to voluntarily expand Medicaid. Our study sought to measure the impact of ACA Medicaid expansion on preventable hospitalization (PH) rates, a measure of access to primary care.

METHODS: We performed an interrupted time series analysis of quarterly hospitalization rates across eight states from 2012 to …

The Effect Of N‐Fertilization On Fatty Acid Composition In Forage Plants, Katarina Arvidsson, Anne-Maj Gustavsson, Kjell Martinsson

IGC Proceedings (1977-2023)

No abstract provided.