Digital Commons Network^™

Predictors Of Chronic Opioid Therapy In Medicaid Beneficiaries With Hiv Who Initiated Antiretroviral Therapy, Gyeon Oh, Emily S. Brouwer, Erin L. Abner, David W. Fardo, Patricia R. Freeman, Chris Delcher, Daniela C. Moga

Epidemiology and Environmental Health Faculty Publications

The factors associated with chronic opioid therapy (COT) in patients with HIV is understudied. Using Medicaid data (2002-2009), this retrospective cohort study examines COT in beneficiaries with HIV who initiated standard combination anti-retroviral therapy (cART). We used generalized estimating equations on logistic regression models with backward selection to identify significant predictors of COT initiation. COT was initiated among 1014 out of 9615 beneficiaries with HIV (male: 10.4%; female: 10.7%). Those with older age, any malignancy, Hepatitis C infection, back pain, arthritis, neuropathy pain, substance use disorder, polypharmacy, (use of) benzodiazepines, gabapentinoids, antidepressants, and prior opioid therapies were positively associated with …

Laser Irradiation As A Novel Alternative To Detach Intact Particulate Matter Collected On Air Filters, Seyed-Mohammadreza Samaee, Rahim Molaei, Robert A. Yokel, Hedieh Pazokian

Pharmaceutical Sciences Faculty Publications

Airborne particulate matter (PM) is collected on specific filters. For subsequent testing, the PM should be detached intact from the filter. Liquid extraction (LE), the standard method to detach PM from air filter surfaces, is challenging and can be tedious. Laser irradiation has been used to characterize PM on filters, but not to detach PM from filters for subsequent testing. A feasibility study was conducted to assess the potential of laser irradiation to detach PM from air filters. Laser-detached PM was deposited on a pre-weighed glass plate. PM detachment and collection were conducted in a single step. PM-coated air filters …

A Narrative Review On The Unexplored Potential Of Colostrum As A Preventative Treatment And Therapy For Diarrhea In Neonatal Dairy Calves, Havelah S. M. Carter, David L. Renaud, Michael A. Steele, Amanda J. Fischer-Tlustos, Joao H. C. Costa

Animal and Food Sciences Faculty Publications

Diarrhea is the leading cause of morbidity and mortality in pre-weaned dairy calves and, as such, represents a significant animal health and welfare concern. Furthermore, digestive disease early in life is associated with several long-term consequences such as reduced growth rate and decreased milk yield during the first lactation, thus generating severe economic losses. The majority of diarrheic cases in young calves are treated with antimicrobials; however, it is necessary to develop alternative treatments, as excessive antimicrobial usage can lead to antimicrobial resistance and can negatively impact the gut microflora of a calf. Bovine colostrum is abundant in immune and …

Food Supply Chains In Developed Countries And Livestock Production Systems, Alan Mcdermott

IGC Proceedings (1977-2023)

No abstract provided.

Review Of: Understanding And Dismantling Racism: Crowdsourcing A Pathway Model In Appalachia, Matthew F. Hudson

Journal of Appalachian Health

The Journal of Appalachian Health is committed to reviewing published media that relates to contemporary concepts affecting the health of Appalachia. Examining Institutional Racism’s impact on health, career advancement and outcomes in Appalachian communities, impacts our ability to address and identify solutions to inform the fundamental framing of health equity. Dr. Matthew F. Hudson critiques the website: Understanding and Dismantling Racism: Crowdsourcing a Pathway Model in Appalachia.

Review Of: Appalachians For Medicaid Website, Kendra Barker Dnp

Journal of Appalachian Health

The Journal of Appalachian Health is committed to reviewing published media that relates to contemporary concepts affecting the health of Appalachia. Access to care and the health disparities we face have a direct effect on our experience of illness. Dr. Kendra Barker reviews the website: Appalachians for Medicaid.

Geospatial Analysis Of Rurality And Food Banks In Appalachian Ohio, Cooper T. Johnson, Rebecca Fischbein, Kristin Baughman

Journal of Appalachian Health

Introduction: Food insecurity is a problem for individuals across Ohio, including those living in Appalachia. Adequate access to resources that help combat food insecurity is important for these populations.

Purpose: To examine how rurality relates to food insecurity and need for food resources, as well as availability of those resources including food pantries and soup kitchens, in 15 northern Ohio Appalachian counties.

Methods: A cross-sectional study with a geographical analysis was conducted using data from the American Community Survey census data, County Health Rankings data, and regional foodbank websites.

Results: Rural counties had a higher ratio of potential clients per …

Triple Negative Breast Cancer In An Appalachian Region: Exponential Tumor Grade Increase With Age Of Diagnosis, Gina Sizemore, Toni Marie Rudisill

Journal of Appalachian Health

Introduction: Triple negative breast cancer is an aggressive breast cancer with decreased five-year survival, increased risk for recurrence, and higher risk for metastases. Unlike other breast cancers, it has no targeted treatment and has heterogeneous genetics which make classification and treatment difficult.

Purpose: The purpose of our research was to compare triple negative breast cancer to non-triple negative breast cancer to identify key epidemiologic factors that might lead to improved basic science directives for biomarkers, treatments, and classification.

Methods: The state cancer registry was used to provide the first West Virginia state-wide population evaluation of triple negative breast cancer.

Results: …

Case Study Of A Comprehensive Team-Based Approach To Increase Colorectal Cancer Screening, Lauren E. Wright, Adam Baus, Andrea Calkins, Holly Hartman-Adams, Mary E. Conn, Susan Eason, Stephenie Kennedy-Rea

Journal of Appalachian Health

Introduction: Colorectal cancer is the second leading cause of cancer deaths among men and women in West Virginia. In addition, 51% of all colorectal cancers diagnosed in West Virginia from 2012 to 2016 were detected at either regional (31%) or distant (20%) stages indicating a need for improved early detection.

Methods: West Virginia University Cheat Lake Physicians participated in the West Virginia Program to Increase Colorectal Cancer Screening, a program of Cancer Prevention and Control at the WVU Cancer Institute. As a result, Cheat Lake Physicians assembled a team of health care professionals to implement evidence-based interventions and …

Addressing Diabetes Distress In Self-Management Programs: Results Of A Randomized Feasibility Study, Ranjita Misra, Samantha Shawley-Brzoska, Raihan Khan, Brenna O. Kirk, Sijin Wen, Usha Sambamoorthi

Journal of Appalachian Health

Background: West Virginia ranks 1st nationally in the prevalence of hypertension (HTN; 43.8%) and diabetes (16.2%). Patients with type 2 diabetes mellitus (T2DM) are distressed over physical and psychological burden of disease self-management.

Methods: This study investigated the effectiveness of an intervention to reduce diabetes distress and outcomes [glycemic control, blood pressure (BP)] among T2DM adults with comorbid HTN. Participants were randomized to a 12-week diabetes and hypertension self-management program versus a 3-month wait-listed control group. Trained health coaches and experts implemented the lifestyle program in a faith-based setting using an adapted evidence-based curriculum. Twenty adults with T2DM and HTN …

Diabetes Knowledge, Behaviors, And Perceptions Of Risk In Rural West Virginia Counties, Ranjita Misra, Sara Farjo, Renee Mcginnis, Megan Adelman Elavsky, Summer Kuhn, Catherine Morton-Mcswain

Journal of Appalachian Health

Introduction: A little less than half of American adults have diabetes or pre-diabetes. In 2016, West Virginia (WV) had the highest percentage (15.2%) of adults with diagnosed diabetes in the U.S.

Purpose: In partnership with the Health Sciences and Technology Academy (HSTA), a cross-sectional study was preformed to assess knowledge, behaviors, and perceptions of diabetes risk.

Methods: Data was collected by trained HSTA students and teachers who lived in rural counties in WV. Information was assessed using validated surveys, and HbA1c was obtained by utilizing professional point-of-care (Bayer) kits.

Results: Mean age and Body Mass Index (BMI) was 36.11±17.86 years …

Establishing Peer Recovery Support Services To Address The Central Appalachian Opioid Epidemic: The West Virginia Peers Enhancing Education, Recovery, And Survival (Wv Peers) Pilot Program, Stephen M. Davis, Amanda Stover, Herb Linn, Jon Dower, Dan Mccawley, Erin Winstanley, Judith Feinberg

Journal of Appalachian Health

Introduction: Central Appalachia has been disproportionately affected by the opioid epidemic and overdose fatalities. We developed West Virginia Peers Enhancing Education, Recovery, and Survival (WV PEERS), a program based on peer recovery support, to engage individuals using opioids and link them with a range of services.

Methods: Community partners providing services to individuals with opioid use disorder (OUD) were identified and collaborations were formalized using a standardized memorandum of understanding. The program was structured to offer ongoing peer recovery support specialist (PRSS) services, not just a one-time referral. A website and cards describing the WV PEERS program were developed and …

Rural Re-Entry And Opioid Use: Identifying Health-Related Predictors Of Relapse Among Formerly Incarcerated Women In Appalachia, Joseph M. Calvert, Megan F. Dickson, Martha Tillson, Erika Pike, Michele Staton

Journal of Appalachian Health

Introduction: Despite improved knowledge of the health care needs of formerly incarcerated women, there exists a gap regarding the relationship between health, health care access, and relapse among rural women returning to the community during the opioid epidemic.

Purpose: With an emphasis on health care access, this study examined health-related factors associated with opioid relapse among women reentering the community in rural Appalachia.

Methods: As part of a larger study, 400 rural women reporting a history of substance use were recruited from three Appalachian jails in Kentucky. Analyses focused on participants reporting a history of illicit opioid use prior to …

Emergence Of Covid-19 And Patterns Of Early Transmission In An Appalachian Sub-Region, Abbey K. Mann, Timothy A. Joyner, Ingrid E. Luffman, Megan Quinn, William Tollefson, Ashley Frazier

Journal of Appalachian Health

Background: In mid-March 2020, very few cases of COVID-19 had been confirmed in the Central Blue Ridge Region, an area in Appalachia that includes 47 jurisdictions across northeast Tennessee, western North Carolina, and southwest Virginia. Authors described the emergence of cases and outbreaks in the region between March 18 and June 11, 2020.

Methods: Data were collected from the health department websites of Tennessee, North Carolina, and Virginia beginning in mid-March for an ongoing set of COVID-19 monitoring projects, including a newsletter for local healthcare providers and a Geographic Information Systems (GIS) dashboard. In Fall 2020, using these databases, authors …

Appalachia: Putting The "Critical" In Race And Crowdsourcing A Pathway Model On Institutional Racism, Lauri Andress, Keri Valentine

Journal of Appalachian Health

As the website Understanding and Dismantling Racism: Crowdsourcing a Pathway Model in Appalachia explains, we are seeking assistance in refining a pathway model that elucidates institutional racism from the unique standpoint of Appalachia. We think that Appalachia has a distinctive cultural toolkit that shapes its orientation on issues. Our goal is to use crowdsourcing to harness this unique Appalachian ethos to refine the Pathway model on Institutional Racism based on comments, edits, questions, and ideas left on the website.

Health Of People And Land Through Sustainable Aboriginal Livelihoods In Rangeland Australia, Jocelyn Davies, Michael Laflamme, David Campbell

IGC Proceedings (1977-2023)

No abstract provided.

Real-World Applications For Analytics Teaching And Learning, Anita Lee-Post

Marketing & Supply Chain Textbook Gallery

This document provides learning-by-doing materials for Analytics software skill development using SAS JMP. It integrates Analytics concepts and techniques with real-world scenarios based on the COVID-19 pandemic to illustrate how real-world data can be transformed into actionable insights to offer decision support for COVID-19 related issues. A holistic treatment of the Analytics process from data acquisition and cleansing to data analysis and interpretation is emphasized using five studies:

1. Characterize COVID-19 mortality demographic risk factors,
2. Visualize COVID-19 mortality demographics,
3. Conduct COVID-19 mortality time series forecasting,
4. Predict COVID-19 mortality, and
5. Analyze COVID-19 vaccine acceptance, uptake, and experiences.

Each study is structured with …

Diagnosis Of Classic Homocystinuria In Two Boys Presenting With Acute Cerebral Venous Thrombosis And Neurologic Dysfunction After Normal Newborn Screening, Alexander Asamoah, Sainan Wei, Kelly E. Jackson, Joseph H. Hersh, Harvey Levy

Pathology and Laboratory Medicine Faculty Publications

Homocystinuria, caused by cystathionine β-synthase deficiency, is a rare inherited disorder involving metabolism of methionine. Impaired synthesis of cystathionine leads to accumulation of homocysteine that affects several organ systems leading to abnormalities in the skeletal, cardiovascular, ophthalmic and central nervous systems. We report a 14-month-old and a 7-year-old boy who presented with neurologic dysfunction and were found to have cerebral venous sinus thromboses on brain magnetic resonance imaging (MRI)/magnetic resonance venogram (MRV) and metabolic and hypercoagulable work-up were consistent with classic homocystinuria. The 14-month-old boy had normal newborn screening. The 7-year-old boy initially had an abnormal newborn screen for homocystinuria …

Math Predictors Of Numeric Health And Non-Health Decision-Making Problems, Clarissa A. Thompson, Jennifer M. Taber, Charles J. Fitzsimmons, Pooja G. Sidney

Psychology Faculty Publications

People frequently encounter numeric information in medical and health contexts. In this paper, we investigated the math factors that are associated with decision-making accuracy in health and non-health contexts. This is an important endeavor given that there is relatively little cross-talk between math cognition researchers and those studying health decision making. Ninety adults (M = 37 years; 86% White; 51% male) answered hypothetical health decision-making problems, and 93 adults (M = 36 years; 75% White; 42% males) answered a non-health decision-making problem. All participants were recruited from an online panel. Each participant completed a battery of tasks involving objective math …

Targeted Oral Delivery Of Paclitaxel Using Colostrum-Derived Exosomes, Raghuram Kandimalla, Farrukh Aqil, Sara S. Alhakeem, Jeyaprakash Jeyabalan, Neha Tyagi, Ashish Agrawal, Jun Yan, Wendy Spencer, Subbarao Bondada, Ramesh C. Gupta

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small-cell lung cancer (NSCLC) is the most common type accounting for 84% of all lung cancers. Paclitaxel (PAC) is a widely used drug in the treatment of a broad spectrum of human cancers, including lung. While efficacious, PAC generally is not well tolerated and its limitations include low aqueous solubility, and significant toxicity. To overcome the dose-related toxicity of solvent-based PAC, we utilized bovine colostrum-derived exosomes as a delivery vehicle for PAC for the treatment of lung cancer. Colostrum provided higher yield of exosomes and could be loaded with higher …

The Fatty Acid Profile Of Traditional Home‐Made Kurut In Xinjiang Pastoral Regions, Yimamu Aibibula, Masaaki Hanada, M. Hirata, M. Renaguli, M. Goto

IGC Proceedings (1977-2023)

No abstract provided.

Multiple Use Management On Canadian Publicly Managed Rangeland, B. Kirychuk, R. Gaube, S. Kushreshtha, G. Pearson

IGC Proceedings (1977-2023)

No abstract provided.

Zebrafish Blunt-Force Tbi Induces Heterogenous Injury Pathologies That Mimic Human Tbi And Responds With Sonic Hedgehog-Dependent Cell Proliferation Across The Neuroaxis, James Hentig, Kaylee Cloghessy, Manuela Lahne, Yoo Jin Jung, Rebecca A. Petersen, Ann C. Morris, David R. Hyde

Biology Faculty Publications

Blunt-force traumatic brain injury (TBI) affects an increasing number of people worldwide as the range of injury severity and heterogeneity of injury pathologies have been recognized. Most current damage models utilize non-regenerative organisms, less common TBI mechanisms (penetrating, chemical, blast), and are limited in scalability of injury severity. We describe a scalable blunt-force TBI model that exhibits a wide range of human clinical pathologies and allows for the study of both injury pathology/progression and mechanisms of regenerative recovery. We modified the Marmarou weight drop model for adult zebrafish, which delivers a scalable injury spanning mild, moderate, and severe phenotypes. Following …

Mobility And Development: Iranian Perspective, Hossein Badripour

IGC Proceedings (1977-2023)

No abstract provided.

Designing Land Taxes To Promote Conservation Through Use Of Rangelands: Bio‐Economic Modeling Of Farm Decision‐Making In Southern Namibia, Stephanie E. Domptail, Ernst‐August Nuppenau

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of Biochanin A On The Rumen Microbial Community Of Holstein Steers Consuming A High Fiber Diet And Subjected To A Subacute Acidosis Challenge, Brittany E. Harlow, Michael D. Flythe, James L. Klotz, David L. Harmon, Glen E. Aiken

Animal and Food Sciences Faculty Publications

Subacute rumen acidosis (SARA) occurs when highly fermentable carbohydrates are introduced into the diet, decreasing pH and disturbing the microbial ecology of the rumen. Rumen amylolytic bacteria rapidly catabolize starch, fermentation acids accumulate in the rumen and reduce environmental pH. Historically, antibiotics (e.g., monensin, MON) have been used in the prevention and treatment of SARA. Biochanin A (BCA), an isoflavone produced by red clover (Trifolium pratense), mitigates changes associated with starch fermentation ex vivo. The objective of the study was to determine the effect of BCA on amylolytic bacteria and rumen pH during …

Suggestions For Grassland Ecosystem Protection And Development In Heilongjiang Province, Y. X. Zhang, G. Q. Han, Duofeng Pan, Z. B. Shen, F. L. Tang

IGC Proceedings (1977-2023)

No abstract provided.

The Anti-Dipsogenic And Anti-Natriorexigenic Effects Of Estradiol, But Not The Anti-Pressor Effect, Are Lost In Aged Female Rats, Jessica Santollo, Jason A. Collett, Andrea A. Edwards

Biology Faculty Publications

Estradiol (E2) inhibits fluid intake in several species, which may help to defend fluid homeostasis by preventing excessive extracellular fluid volume. Although this phenomenon is well established using the rat model, it has only been studied directly in young adults. Because aging influences the neuronal sensitivity to E2 and the fluid intake effects of E2 are mediated in the brain, we tested the hypothesis that aging influences the fluid intake effects of E2 in female rats. To do so, we examined water and NaCl intake in addition to the pressor effect after central angiotensin II treatment in young (3-4 months), …

Casting Off The "Fertile Poverty": Policy Research On Development Of The Altiplano Pasturing Area Within The Upper Reaches Of The Yangtze River--Case Study Of Ganzi Tibetan Autonomous Prefecture, Shiqing Liu

IGC Proceedings (1977-2023)

No abstract provided.

Analysis Of Pretreatment Factors Associated With Stability In Early Class Iii Treatment, Yasuko Inoue, Toru Deguchi, James K. Hartsfield Jr., Wakako Tome, Noriyuki Kitai

Oral Health Science Faculty Publications

BACKGROUND: The purpose of this study was to identify pretreatment factors associated with the stability of early class III treatment, since most orthodontists start the treatment with their uncertain hypotheses and/or predictions. Subjects consisted of 75 patients with a class III skeletal relationship (ANB < 2° and overjet < 0 mm) who had been consecutively treated with rapid maxillary expansion and facemask and followed until their second phase treatment. The patients were divided into two groups according to whether they showed relapse in follow-up. The stable group maintained their positive overjet (n = 55), and the unstable group experienced relapse with a zero or negative overjet (n = 20). Two general, three dental, and 13 cephalometric pretreatment factors were investigated to determine which factors were associated with stability.

RESULTS: Sex, pretreatment age, and anteroposterior functional shift, which were hypothesized as associated factors, were not related to …