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Score Equating Between Aeps-2 And Aeps-3 For 0-3 Year Olds, Yuyan Xia

Theses and Dissertations--Education Sciences

Over the past two decades, the emphasis on educational equity in early childhood education (ECE) and early childhood special education (ECSE) has highlighted the importance of assessment through policies and regulations. Ensuring accurate assessment scores is a fundamental aspect of this trend. The release of the Assessment, Evaluation, and Programming System for Infants and Children, Third Edition (AEPS-3) in December 2021 led to a shift from the Second Edition (AEPS-2) in child development scoring. In order to harmonize the previous and updated assessment versions for children aged 0-3 across six developmental domains, a common item non-equivalent design, featuring fixed parameter …

Survey Development And Validation: Student Self Expectations Of The First-Year College Experience Survey (The Se-Fye Scale), Min Xiao

Theses and Dissertations--Education Sciences

First year at a university is often a transitional stage for students where they have opportunities to grow and develop in various areas and get familiar with a collegiate environment. Understanding what first-year students expect to navigate and succeed in their first year at the university is crucial. Their expectations reflect how well they prepared for university, affecting their behaviors and eventually influencing their intentions to continue higher education. One of the primary purposes of this study was to design a survey to measure student self-expectations of the first-year college experience (the SE-FYE scale) by applying a structured survey development …

Uk College Of Medicine African-American Medical Students' Experience With Faculty Mentoring, Ashlee-Nicole C. Hamilton

Theses and Dissertations--Educational Policy Studies and Evaluation

This research study explored the faculty mentoring experiences of African-American medical students at the University of Kentucky College of Medicine (UK COM). The purpose of the research is to determine benefits and challenges expressed by the African-American students so that UK COM can use the student voices to improve faculty mentoring for this student population. The following broad questions guided the research: 1) What are UK College of Medicine African-American medical students’ experiences with faculty mentoring? 2) What are UK College of Medicine African-American medical students’ experience with faculty mentoring on a satellite regional campus? Specifically, the investigation seeks to …

Minimum High School Graduation Requirements And Teacher Compensation, Allison Johnson

Theses and Dissertations--Educational Policy Studies and Evaluation

In the last forty years of educational reform, significant changes have been made to the number and type of high school credits students are required to complete for graduation. As these requirements have changed, the demand for higher-level academic courses has increased while teacher shortages, particularly in high-demand areas such as math and science, have continued to increase. This study uses data from the National Center for Education Statistics (NCES) Student and Staffing Survey to examine the relationship between minimum graduation credit requirements in core subject areas (English, math, science and social sciences) and teacher salaries, both holistically and in …

An Exploration Of Athlete Thoughts And Perceptions Of Cohesion In Coacting Sports, Jared Scott Hrabcak

Theses and Dissertations--Kinesiology and Health Promotion

Cohesion is a central element in group dynamics that contributes to a team’s functioning and performance. Most of the cohesion research to date has focused on the dynamic within interacting sport teams (i.e., football, basketball, soccer) but has looked past coacting teams (i.e., golf, tennis, cross-country running). While interacting sports command worldwide popularity, a significant portion of student athletes compete in coacting sports and represent the bulk of NCAA affiliated participants on the world stage at the Olympics. Thus, with such status on the world stage of competition, the investigation of coacting sports is justified. Therefore, the purpose of this …

Food Insecurity On College Campuses: Addressing The Issue Through A Student-Centered Perspective, Thomas Ard

Theses and Dissertations--Kinesiology and Health Promotion

Research indicates food insecurity (FI) has become a consistent challenge for college students. However, more is needed regarding the students' lived experiences of food insecurity following the COVID-19 pandemic. Universities play a vital role in assisting students with food insecurity through food assistance programs, on-campus resources, and financial help, which impacts their physiological needs and academic performance. A better understanding of what influences students' perceptions and decisions about whether to engage in these resources is essential.

This dissertation's purpose was to explore how college students living with food insecurity experience engaging in food assistance programs (FAP). The study used a …

An Exploration Of Service Needs And Preferences Of Dementia Caregivers In Kentucky, Heehyul Moon, Sunshine Rote, Allison Kacmar, Amy Kostelic, Bari Lewis

Family Sciences Faculty Publications

As Americans live longer, the prevalence of Alzheimer’s disease and related dementias will increase. Caregivers are critical to the care and life quality of people with dementia. Yet, dementia caregivers are at increased risk for health issues, social isolation, and financial challenges. To help educators with the University of Kentucky Cooperative Extension Service work with their local Alzheimer’s Association and the University of Louisville to better support dementia families, we explored caregiver needs and service utilization using an online survey. Our findings highlighted the need for counseling/support, care management skills, resource education, self-care strategies, and legal services. Extension Service Educators …

Evaluation Of Blood-Based, Extracellular Vesicles As Biomarkers For Aging-Related Tdp-43 Pathology, Charisse N. Winston, Sonal Sukreet, Haley Lynch, Virginia M. -Y. Lee, Donna M. Wilcock, Peter T. Nelson, Robert A. Rissman

Neurology Faculty Publications

Introduction: Limbic predominant age related TDP-43 encephalopathy neuropathological change (LATE-NC) is a recently characterized brain disease that mimics Alzheimer’s disease (AD) clinically. To date, LATE-NC is difficult to diagnose antemortem using clinical information or biomarkers. Recent studies suggest concentrations of extracellular vesicle (EVs) protein cargo derived from neuronal and glial cells may serve as useful diagnostic biomarkers for AD and other neurodegenerative diseases.

Methods: TDP-43 was evaluated in neuronal (NDEVs), astrocyte (ADEVs), and microglial derived extracellular vesicles (MDEVs). EV preparations were isolated from the plasma of research subjects with autopsy-confirmed diagnoses, including many with LATE (n = 22). …

Rna Editing Of Microtubule-Associated Protein Tau Circular Rnas Promotes Their Translation And Tau Tangle Formation, Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti, Sandra C. Miranda Sardón, Alexandre Rosa Campos, Noémie Robil, Daniel C. Lee, Alvaro G. Hernandez, Wang-Xia Wang, Jing Di, Pierre De La Grange, Peter T. Nelson, Stefan Stamm

Sanders-Brown Center on Aging Faculty Publications

Aggregation of the microtubule-associated protein tau characterizes tauopathies, including Alzheimer’s disease and frontotemporal lobar degeneration (FTLD-Tau). Gene expression regulation of tau is complex and incompletely understood. Here we report that the human tau gene (MAPT) generates two circular RNAs (circRNAs) through backsplicing of exon 12 to either exon 7 (12→7 circRNA) or exon 10 (12→10 circRNA). Both circRNAs lack stop codons. The 12→7 circRNA contains one start codon and is translated in a rolling circle, generating a protein consisting of multimers of the microtubule-binding repeats R1–R4. For the 12→10 circRNA, a start codon can be introduced by two …

Genetic Expression Changes And Pathologic Findings Associated With Hyperhomocysteinemia In Human Autopsy Brain Tissue, Erica M. Weekman, Zachary Winder, Colin B. Rogers, Erin L. Abner, Tiffany L. Sudduth, Ela Patel, Adam J. Dugan, Shuling X. Fister, Brandi Wasek, Peter T. Nelson, Gregory A. Jicha, Teodoro Bottiglieri, David W. Fardo, Donna M. Wilcock

Sanders-Brown Center on Aging Faculty Publications

Introduction: Vascular contributions to cognitive impairment and dementia (VCID) are a leading cause of dementia. An underappreciated, modifiable risk factor for VCID is hyperhomocysteinemia (HHcy), defined by elevated levels of plasma homocysteine, most often due to impaired B vitamin absorption in aged persons. Studies aimed at identifying neuropathologic features and gene expression profiles associated with HHcy have been lacking.

Methods: A subset of research volunteers from the University of Kentucky Alzheimer’s Disease Research Center longitudinal cohort came to autopsy and had ante mortem plasma homocysteine levels available. Brain tissue and blood plasma drawn closest to death were used to measure …

Apoe Genetics Influence Murine Gut Microbiome, Diana J. Zajac, Stefan J. Green, Lance A. Johnson, Steven Estus

Sanders-Brown Center on Aging Faculty Publications

Apolipoprotein E (APOE) alleles impact pathogenesis and risk for multiple human diseases, making them primary targets for disease treatment and prevention. Previously, we and others reported an association between APOE alleles and the gut microbiome. Here, we evaluated effects of APOE heterozygosity and tested whether these overall results extended to mice maintained under ideal conditions for microbiome analyses. To model human APOE alleles, this study used APOE targeted replacement (TR) mice on a C57Bl/6 background. To minimize genetic drift, homozygous APOE3 mice were crossed to homozygous APOE2 or homozygous APOE4 mice prior to the study, and the resulting …

Acute Invasive Fungal Rhinosinusitis Related Orbital Infection Secondary To Odontogenic Infection, Dennis Levy, Melvyn Yeoh

Oral Health Science Faculty Publications

A 64-year old male presented to our institution with painful ophthalmoplegia. The initial differential diagnosis included orbital apex disorders, such as orbital apex syndrome (OAS), cavernous sinus thrombosis (CST), and superior orbital fissure syndrome (SOFS). Ultimately, the diagnosis was acute invasive fungal rhinosinusitis (AIFRS) secondary to an odontogenic infection from carious teeth in the maxilla. Significant overlap exists between AIFRS and orbital apex disorders, making it prudent to include AIFRS in the differential diagnosis for painful ophthalmoplegia. The purpose of this review is to detail this specific patient's presentation and hospital course along with a brief review of AIFRS and …

An Evaluation Of Injurious Falls And Fall-Risk-Increasing-Drug (Frid) Prescribing In Ambulatory Care In Older Adults, Taylor R. Elliott, Susan Westneat, Shama D. Karanth, Erin L. Abner, Anna M. Kucharska‑Newton, Daniela C. Moga

Epidemiology and Environmental Health Faculty Publications

Background: Falls are a major public health problem afecting millions of older adults each year. Little is known about FRID prescribing behaviors after injurious falls occur. The primary objective of this study was to investigate whether an injurious fall is associated with being prescribed a new FRID.

Methods: We conducted a cross-sectional analysis using data from the National Ambulatory Medical Care Survey (2016). We included visits from patients age≥65 years and classifed visits based on presence of an injurious fall. The outcome of interest was prescription of new FRID between those with and without an injurious fall. Multivari‑ …

Single Low-Dose Targeted Bevacizumab Infusion In Adult Patients With Steroid-Refractory Radiation Necrosis Of The Brain: A Phase Ii Open-Label Prospective Clinical Trial, Shervin R. Dashti, Robert J. Kadner, Bradley S. Folley, Jason P. Sheehan, Dong Y. Han, Richard J. Kryscio, Mary B. Carter, Lisa B. E. Shields, Brian M. Plato, Renato V. La Rocca, Aaron C. Spalding, Tom L. Yao, Justin F. Fraser

Sanders-Brown Center on Aging Faculty Publications

OBJECTIVE There is an unmet need for safe and rapidly effective therapies for refractory brain radiation necrosis (RN). The aim of this prospective single-arm phase II trial was to evaluate the safety and efficacy of a single low-dose targeted bevacizumab infusion after blood-brain barrier disruption (BBBD) in adult patients with steroid-refractory brain RN.

METHODS Ten adults with steroid-refractory, imaging-confirmed brain RN were enrolled between November 2016 and January 2018 and followed for 12 months after treatment. Bevacizumab 2.5 mg/kg was administered as a one-time targeted intra-arterial infusion immediately after BBBD. Primary outcomes included safety and > 25% decrease in lesion volume. …

Estimating The Distribution Of Ratio Of Paired Event Times In Phase Ii Oncology Trials, Li Chen, Mark Burkard, Jianrong Wu, Jill M. Kolesar, Chi Wang

Markey Cancer Center Faculty Publications

With the rapid development of new anti-cancer agents which are cytostatic, new endpoints are needed to better measure treatment efficacy in phase II trials. For this purpose, Von Hoff (1998) proposed the growth modulation index (GMI), that is, the ratio between times to progression or progression-free survival times in two successive treatment lines. An essential task in studies using GMI as an endpoint is to estimate the distribution of GMI. Traditional methods for survival data have been used for estimating the GMI distribution because censoring is common for GMI data. However, we point out that the independent censoring assumption required …

Beliefs Associated With Cancer Screening Behaviors Among African Americans And Sub-Saharan African Immigrant Adults: A Cross-Sectional Study, Adebola Adegboyega, Amanda T. Wiggins, Omoadoni Roseline Obielodan, Mark Dignan, Nancy E. Schoenberg

Nursing Faculty Publications

Background: Beliefs infuence cancer screening. However, there are conficting fndings about how belief infuence cancer screening among Black adults. The aim of this study was to evaluate the relationships between beliefs (religiosity, fatalism, temporal orientation, and acculturation) and cervical, breast, and colorectal cancer screening behaviors among African Americans and sub-Saharan African immigrants.

Methods: We conducted a cross-sectional survey of 73 African American and 59 English speaking Sub-Saharan immigrant adults recruited from Lexington and surrounding cities in Kentucky. Data collected included sociodemographic variables, cancer screening behaviors, and several instruments that characterize beliefs, including religiosity, fatalism, temporal orientation, and acculturation. …

The Association Of Gabapentin Initiation And Neurocognitive Changes In Older Adults With Normal Cognition, Gyeon Oh, Daniela Claudia Moga, David W. Fardo, Erin L. Abner

Sanders-Brown Center on Aging Faculty Publications

Background: Gabapentin is increasingly prescribed to older adults, which raises concerns about its potential to cause neurocognitive changes. Therefore, we aimed to examine the association of gabapentin use with neurocognitive changes (i.e., cognitive decline, functional status decline, and motor function change) in older adults.

Methods: We conducted a retrospective cohort study using the National Alzheimer’s Coordinating Center Uniform Data Set (UDS; September 2005-March 2021 data freeze). From the eligible sample (≥age 65 years), we identified cognitively normal new-users of gabapentin and the visit they initiated gabapentin (i.e., index visit). Initiators were matched to randomly selected nonusers on year …

Examining Four Blood Biomarkers For The Detection Of Acute Intracranial Abnormalities Following Mild Traumatic Brain Injury In Older Adults, Grant L. Iverson, Mira Minkkinen, Justin E. Karr, Ksenia Berghem, Henrik Zetterberg, Kaj Blennow, Jussi P. Posti, Teemu M. Luoto

Psychology Faculty Publications

Blood-based biomarkers have been increasingly studied for diagnostic and prognostic purposes in patients with mild traumatic brain injury (MTBI). Biomarker levels in blood have been shown to vary throughout age groups. Our aim was to study four blood biomarkers, glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase-L1 (UCH-L1), neurofilament light (NF-L), and total tau (t-tau), in older adult patients with MTBI. The study sample was collected in the emergency department in Tampere University Hospital, Finland, between November 2015 and November 2016. All consecutive adult patients with head injury were eligible for inclusion. Serum samples were collected from the enrolled patients, …

Range-Based Livestock Production In Turkmenistan, R. H. Behnke, G. Davidson

IGC Proceedings (1977-2023)

Turkmenistan retains a centralized system of livestock production in which many critical assets are owned by the state. Though technically in the temperate zone, the country's climate is harsh and unstable. Groundwater resources are unevenly distributed, leaving many potential grazing areas seasonally inaccessible due to lack of drinking water for livestock. This paper summarizes the results of a three-year study of rangelands, livestock production, flock economics and land tenure at two study sites, one in central and the other in eastern Turkmenistan. The results of this study suggest that pastoral communities in Turkmenistan have coped remarkably well with the institutional …

Scale Modeling Of An Appearance Of Downwash Pattern Of Hot Smoke Ejected From Chimney In The Turbulent Cross Flow, Xangpheuak Inthavideth, Nobumasa Sekishita, Sounthisack Phommachanh, Yuji Nakamura

Progress in Scale Modeling, an International Journal

This study aims to elucidate the scaling law to provide the critical condition on appearance of the downwash pattern of the hot smoke ejected from a chimney in a turbulent cross flow. A specially designed wind tunnel with an active turbulence generator developed by Makita was adopted to offer a quasi-isotropic turbulence field in a lab-scale test facility. A heated jet with smoke is issued into the cross flow from the vertically oriented chimney placed in the test section of the wind tunnel. In this study, the experimental parameters considered are temperature of the heated jet (smoke), jet ejected velocity, …

Adaptation And Study Protocol Of The Evidence-Based Make Better Choices (Mbc2) Multiple Diet And Activity Change Intervention For A Rural Appalachian Population, Nancy E. Schoenberg, Deanna Sherman, Angela Fidler Pfammatter, Michelle K. Roberts, Ming-Yuan Chih, Sarah Cornelia Vos, Bonnie Spring

Behavioral Science Faculty Publications

Background: Rural Appalachian residents experience among the highest prevalence of chronic disease, premature mortality, and decreased life expectancy in the nation. Addressing these growing inequities while avoiding dupli‑ cating existing programming necessitates the development of appropriate adaptations of evidence-based lifestyle interventions. Yet few published articles explicate how to accomplish such contextual and cultural adaptation.

Methods: In this paper, we describe the process of adapting the Make Better Choices 2 (MBC2) mHealth diet and activity randomized trial and the revised protocol for intervention implementation in rural Appalachia. Deploying the NIH’s Cultural Framework on Health and Aaron’s Adaptation framework, the …

Effect Of Soil Chemistry On Microbial Biodiversity And Functionality In Grassland And Tilled Soils, C. Carrigg, S. Kavanagh, D. Fay, V. O. Flaherty

IGC Proceedings (1977-2023)

Microorganisms are excellent indicators of soil health, because of their rapid response to environmental change. Traditional microbiology is ineffective for the study of soil, as < 1% of microorganisms are currently culturable (Torsvik et al., 1996). Nucleic acid based methods, however, allow rapid detection of organisms, or particular genes, directly from soil samples. This work investigated, using polymerase chain reaction (PCR)-based approaches, the relationship between key chemical properties and bacterial biodiversity in grassland and tilled soils, with particular emphasis on the abundance and diversity of ammonium oxidisers.

Chemical Components And Effects On Soil Quality In Temperate Grazed Pasture Systems, M. H. Beare, D. Curtin, S. Thomas, P. M. Fraser, G. S. Francis

IGC Proceedings (1977-2023)

Key points

1. Legume/grass pastures retain feedbacks on N supply that may help to reduce losses of N to the wider environment.

2. Intensive use of N fertilisers tends to increase SOM turnover and increase losses of N to the environment.

3. Increased use of fertilisers has contributed little to soil organic matter storage in grazed pastoral systems.

The Contribution Of Participatory Research: On-Farm Research, P. F. Fennessy, N. J. Daniels, S. A. Chadwick, P. A. Speck

IGC Proceedings (1977-2023)

Participatory research in agriculture may range from research and technology development (R&D), carried out on a research station with some involvement of farmers, through to genuine participatory research involving researchers and farmers working together. The latter involves the end-user in actually carrying out aspects of the research and/or in the development and evaluation of technology that is appropriate to commercial enterprises. Researchers often question the validity of the ‘findings of on-farm participatory research’ as they are more comfortable with the ‘controlled’ environment of the research station. However if research is to be applied appropriately on farms, it must go through …

Participatory Research For Smallholder Livestock Systems: Applying Common Sense To Complex Problems, P. M. Horne, Werner Stür

IGC Proceedings (1977-2023)

Key Points:

1. Participatory approaches to research (PAR) bring researchers closer to farmers, the intended users of research outputs.

2. Active, functional participation of farmers in the evaluation and development of new technologies requires researchers to make an important commitment: respecting the knowledge, skills and opinions of farmers while maintaining confidence in their own scientific knowledge.

3. Farmer experimentation is not usually suitable to provide quantitative biophysical data (this can be achieved more effectively in researcher controlled experiments), but to provide qualitative information and improve understanding. This type of information can be collected systematically to enable rigorous analysis.

4. While …

Soil Biology And The Emergence Of Adventive Grassland Ecosystems, T. R. Seastedt

IGC Proceedings (1977-2023)

The last few years have seen an explosion of information on the responses and feedbacks of soil biota to species and environmental changes. Soil biologists, plant ecologists, and biogeochemists have been searching for patterns, generality and predictability in these relationships. A few brave souls have had the courage to assemble comprehensive assessments of soil biology in our rapidly changing world. Several years ago, I reviewed Wardle’s (2002) book emphasising the links between above- and belowground components of ecosystems. That activity – as well as the present one – provided me with the opportunity to survey recent findings in soil biology. …

Deep Learning Algorithm Reveals Probabilities Of Stage-Specific Time To Conversion In Individuals With Neurodegenerative Disease Late, Xinxing Wu, Chong Peng, Peter T. Nelson, Qiang Cheng

Sanders-Brown Center on Aging Faculty Publications

Introduction: Limbic-predominant age-related TAR DNA-binding protein 43 (TDP-43) encephalopathy (LATE) is a recently defined neurodegenerative disease. Currently, there is no effective way to make a prognosis of time to stage-specific future conversions at an individual level.

Methods: After using the Kaplan–Meier estimation and log-rank test to confirm the heterogeneity of LATE progression, we developed a deep learning–based approach to assess the stage-specific probabilities of time to LATE conversions for different subjects.

Results: Our approach could accurately estimate the disease incidence and transition to next stages: the concordance index was at least 82% and the integrated Brier score …

Decision Support For Grassland Systems In Developing Countries, P. K. Thornton

IGC Proceedings (1977-2023)

Key points

1. Information flows in complex systems are often themselves highly complex, and decision support approaches based on linear input-output processes may have only limited impact.

2. How decisions are made, and how they can be appropriately supported, is often incompletely understood, in part because of inadequate understanding of the objectives and attitudes of all the decision makers involved.

3. Much of the developing world faces daunting problems in the coming 30 years, and appropriate information could play a critical role in dealing with these.

4. System complexity, household variability, and institutional intricacies have to be embraced rather than …

Examining The Effects Of Formal Education Level On The Montreal Cognitive Assessment, Renee S. White, Justin M. Barber, Jordan P. Harp, Gregory A. Jicha

Sanders-Brown Center on Aging Faculty Publications

Background: Brief, global assessments such as the Montreal Cognitive Assessment (MoCA) are widely used in primary care for assessing cognition in older adults. Like other neuropsychological instruments, lower formal education can influence MoCA interpretation.

Methods: Data from 2 large studies of cognitive aging were used—Alzheimer’s Disease Neuroimaging Initiative (ADNI) and National Alzheimer’s Coordinating Center (NACC). Both use comprehensive examinations to determine cognitive status and have brain amyloid status for many participants. Mixed models were used to account for random variation due to data source.

Results: Cognitively intact participants with lower education (≤12 years) were more likely than …

Multiple Gene Variants Linked To Alzheimer's-Type Clinical Dementia Via Gwas Are Also Associated With Non-Alzheimer's Neuropathologic Entities, Yuriko Katsumata, Lincoln M. P. Shade, Timothy J. Hohman, Julie A. Schneider, David A. Bennett, Jose M. Farfel, Walter A. Kukull, David W. Fardo, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

The classic pathologic hallmarks of Alzheimer’s disease (AD) are amyloid plaques and neurofibrillary tangles (AD neuropathologic changes, or ADNC). However, brains from individuals clinically diagnosed with “AD-type” (amnestic) dementia usually harbor heterogeneous neuropathologies in addition to, or other than, ADNC. We hypothesized that some AD-type dementia associated genetic single nucleotide variants (SNVs) identified from large genomewide association studies (GWAS) were associated with non-ADNC neuropathologies. To test this hypothesis, we analyzed data from multiple studies with available genotype and neuropathologic phenotype information. Clinical AD/dementia risk alleles of interest were derived from the very large GWAS by Bellenguez et al. (2022) who …