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Impaired Microvascular Reactivity To Passive Limb Movement After Stroke Is Improved By A Single Session Of Ischemic Conditioning, Alicen A. Whitaker-Hilbig, Jennifer N. Nguyen, Amanda Wietrzny, Akash Desai, Samuel Wietrzny, Macey Dunn, Yelyzaveta Merenzon, Sergey Tarima, Emilie Klevenow, Allison S. Hyngstrom, Matthew J. Durand Jul 2026

Impaired Microvascular Reactivity To Passive Limb Movement After Stroke Is Improved By A Single Session Of Ischemic Conditioning, Alicen A. Whitaker-Hilbig, Jennifer N. Nguyen, Amanda Wietrzny, Akash Desai, Samuel Wietrzny, Macey Dunn, Yelyzaveta Merenzon, Sergey Tarima, Emilie Klevenow, Allison S. Hyngstrom, Matthew J. Durand

Biostatistics Faculty Publications

BACKGROUND: Microvascular dysfunction post stroke remains insufficiently investigated and may contribute to impairments in physical function. Single passive limb movement (sPLM) provides a clinically relevant assessment of microvascular vasodilation. We hypothesized the response to sPLM would be attenuated in the paretic leg compared with age- and sex-matched controls (CON) and would improve following a single session of ischemic conditioning (IC), an intervention known to enhance vasodilation. METHODS: In this randomized crossover trial, superficial femoral artery leg blood flow was measured during sPLM, using a Biodex dynamometer, which passively moved the leg 90° at 1Hz. A thigh cuff was placed around …

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Exercise Training Prior To And During Cancer In Mice Preserves Muscle Mass, Reduces Tumour Weight And Suppresses Molecular Mediators Of Cachexia, Stavroula Tsitkanou, Pieter J. Koopmans, Ana Regina Cabrera, Nathan Serrano, Calvin S. Peterson, Ruqaiza Muhyudin, Zain B. Malik, Micah Goeke, Eleanor R. Schrems, Francielly Morena, Yuan Wen, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene Jul 2026

Exercise Training Prior To And During Cancer In Mice Preserves Muscle Mass, Reduces Tumour Weight And Suppresses Molecular Mediators Of Cachexia, Stavroula Tsitkanou, Pieter J. Koopmans, Ana Regina Cabrera, Nathan Serrano, Calvin S. Peterson, Ruqaiza Muhyudin, Zain B. Malik, Micah Goeke, Eleanor R. Schrems, Francielly Morena, Yuan Wen, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene

Physiology Faculty Publications

Abstract: We investigated the prophylactic effects of exercise before and during cancer cachexia (CC) using a model designed to mimic endurance and resistance (i.e., concurrent) adaptations. Male and female Balb/c mice were randomly assigned to exercise or control groups whereby exercise groups were subjected to an 8-week voluntary progressive weighted wheel running (PoWeR) programme of habitual loading-mediated physical activity beginning at 8 weeks of age. At 16 weeks of age, mice were injected bilaterally with colon-26 adenocarcinoma (C26) cells or phosphate-buffered saline, and exercise training was maintained throughout disease progression. Twenty-five days post-tumour induction, we assessed whole-body and muscle phenotype, …

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Rearing Of Lambs On Intensively Managed Pastures In The Carpathian Region And Its Problems, Jozef Habovstiak Jul 2026

Rearing Of Lambs On Intensively Managed Pastures In The Carpathian Region And Its Problems, Jozef Habovstiak

IGC Proceedings (1977-2023)

One of the patterns of utilizing the good pro­ductivity of grass stands in the Carpathian region consists in the intensive rearing of lambs in a pasture system. In the individual pasture farms, 350 to 700 kg of meat per ha were pro­duced over a grazing period of 130 to 150 days. A very important factor in this pasture system is the planning of technical equipment (fences, sheds, etc.). The most critical problem is, however, to keep the lambs in good health. In each pasture farm, therefore, periodical veterinary attendance and strict sanitary ar­rangements must be integral parts of the fight …

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Influence Of Feeding On Health And Productivity Of Ruminants, Alexander Sommer Jul 2026

Influence Of Feeding On Health And Productivity Of Ruminants, Alexander Sommer

IGC Proceedings (1977-2023)

As to the utilization of plant matter not suited for direct consumption by man, ruminants are of outstanding importance. This fact is related with the function of their specific stom­ach system. The paper discusses the microbial protein synthesis from NPN compounds. When 50 per cent of digestible crude protein required by fattening cattle were replaced, daily live weight gains of 997 g were reached; beef quality was not affected. Similarly favourable results were obtained with dairy cows when replacing by NPN compounds 50 to 100 per cent of extracted meals. Further on, the problem of crude-fibre diges­tion in connection with …

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Performance Evaluation Of The Xpert® Hcv Test On Fingerstick Blood In A Prospective Observational Clinical Study At Clia-Waived Sites In The United States, Jennifer R. Havens, Shelly Ann Fluker, Jonathan Schimmel, L. Madeline Mccrary, Lesley S. Miller, Tomoko Udo, Yukari C. Manabe, Anne Luetkemeyer, Greer Burkholder, Andrew M. Moon, Cody A. Chastain, Jennifer C. Price, John Cafardi, Juan F. Gallegos-Orozco, Brittany A. Young, Jesse Young, Carlos Aparicio, Yu Song, Eric Lai, Gail E. Louw Jul 2026

Performance Evaluation Of The Xpert® Hcv Test On Fingerstick Blood In A Prospective Observational Clinical Study At Clia-Waived Sites In The United States, Jennifer R. Havens, Shelly Ann Fluker, Jonathan Schimmel, L. Madeline Mccrary, Lesley S. Miller, Tomoko Udo, Yukari C. Manabe, Anne Luetkemeyer, Greer Burkholder, Andrew M. Moon, Cody A. Chastain, Jennifer C. Price, John Cafardi, Juan F. Gallegos-Orozco, Brittany A. Young, Jesse Young, Carlos Aparicio, Yu Song, Eric Lai, Gail E. Louw

Epidemiology and Environmental Health Faculty Publications

Background: A major barrier to hepatitis C virus (HCV) elimination in the United States is the lack of a point-of-care test to confirm the presence of HCV RNA. The purpose of this clinical trial was to evaluate the performance of the Xpert® HCV test at CLIA-waived sites in the United States. Methods: Participants at risk and/or with signs/symptoms of HCV infection provided fingerstick blood that was tested on the Xpert® HCV test and venous blood tested using the cobas® HCV and Elecsys® Anti-HCV II tests. Fingerstick blood was collected at CLIA-waived sites by individuals self-trained on collection procedures. Results: Participants …

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The Radial And Vertical Structure Of Molecular Gas In The Edge-On Galaxy Ngc 4565, Grace Krahm, Adam K. Leroy, Jiayi Sun, Kijeong Yim, Eric W. Koch, Tony Wong, Deanne Fisher, Erik Rosolowsky, Karin Sandstrom, Dyas Utomo, Jesse Van De Sande, Marie Martig, Amelia Fraser-Mckelvie, Michael R. Hayden Jul 2026

The Radial And Vertical Structure Of Molecular Gas In The Edge-On Galaxy Ngc 4565, Grace Krahm, Adam K. Leroy, Jiayi Sun, Kijeong Yim, Eric W. Koch, Tony Wong, Deanne Fisher, Erik Rosolowsky, Karin Sandstrom, Dyas Utomo, Jesse Van De Sande, Marie Martig, Amelia Fraser-Mckelvie, Michael R. Hayden

Physics and Astronomy Faculty Publications

We present high-resolution (0 (Formula presented) .″ 94 ≈ 55 pc) Atacama Large Millimeter/submillimeter Array (ALMA) CO(2–1) and13CO(2–1) observations of the highly inclined ( (Formula presented) i∼87.°5 ) galaxy NGC 4565 covering out to galactocentric radius Rgal ≳ ± 17 kpc. The combination of sensitivity and resolution enables the detection of CO emission well into the H i-dominated outer disk while isolating individual molecular clouds across the full extent of the galaxy. Although often described as an edge-on Milky Way analog, the molecular gas profile of NGC 4565 has a central gap that is more similar to …

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Pathologic Misclassification Of Renal Cell Carcinoma In Adolescents And Young Adults, Megan Stout, Derek B. Allison, Leslie Peard, Will Cranford, Yana B. Feygin, Kara Mcabee, Christopher J. Mclouth, Patrick J. Hensley, Jason R. Bylund, Amanda F. Buchanan Jul 2026

Pathologic Misclassification Of Renal Cell Carcinoma In Adolescents And Young Adults, Megan Stout, Derek B. Allison, Leslie Peard, Will Cranford, Yana B. Feygin, Kara Mcabee, Christopher J. Mclouth, Patrick J. Hensley, Jason R. Bylund, Amanda F. Buchanan

Biostatistics Faculty Publications

Background and Objective: Diagnosis of TFE3-rearranged RCC (tRCC) requires a pathologist’s expertise and a high index of suspicion. The objectives of this study were to determine the rate of misclassification of RCC in the adolescent and young adult (AYA) patient population, identify any clinically significant impact associated with misclassification, and compare oncologic outcomes between patients with tRCC vs. other RCC subtypes. Methods: All patients < 50 years who underwent renal surgery and were diagnosed with renal cell carcinoma at a single institution from 2004 to 2019 were identified retrospectively. Pathology specimens were reviewed by a genitourinary pathologist. Changes in a pathologic diagnosis were denoted as “misclassified.” Clinical and oncologic data were analyzed comparing misclassified and non-misclassified groups as well as tRCC and other RCC diagnoses. A survival analysis was used to compare oncologic outcomes. Results: In total, 169 patients were identified, and 20/169 (11.8%) patients were misclassified after pathologic review, with 50% (n = 84) of this cohort < 40 years of age at diagnosis. There were significant differences between misclassified and non-misclassified groups with respect to race (p = 0.002), Appalachian county status (p = 0.035), and initial RCC subtype (p = 0.004). There were no significant differences in clinical or oncologic outcomes between tRCC and other RCC groups. There were no significant differences in time to death or recurrence in misclassified vs. non-misclassified patients (p = 0.83 and 0.68, respectively) or between patients with tRCC and other RCC subtypes (p = 0.45 and 0.062, respectively). Conclusions: >10% of patients with RCC were misclassified on the original pathologic diagnosis; however, there was no significant impact on oncologic outcomes. This identifies diagnostic blind spots for tRCC diagnosis in a young cohort. Perhaps reflex IHC …

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Inflammation Associated With Obesity, Aging, And Amyloid Burden In Adults With Down Syndrome, Victoria L. Fleming-Batayneh, Brian C. Helsel, Lauren T. Ptomey, Benjamin L. Handen, Mark Mapstone, Melissa Petersen, Sharon J. Krinsky-Mchale, Christy L. Hom, Davneet Minhas, Weiquan Luo, Charles Laymon, Joseph H. Lee, Annie Cohen, Beau M. Ances, Adam M. Brickman, Margaret Pulsifer, H. Diana Rosas, Florencia Lai, Shahid H. Zaman, Elizabeth Head, Dana Tudorascu, Julie Price, Fredrick Schmitt, Bradley T. Christian, Ozioma Okonkwo, Sigan L. Hartley, Beau M. Ances, Howard F. Andrews, Karen Bell, Rasmus M. Birn, Adam M. Brickman Jul 2026

Inflammation Associated With Obesity, Aging, And Amyloid Burden In Adults With Down Syndrome, Victoria L. Fleming-Batayneh, Brian C. Helsel, Lauren T. Ptomey, Benjamin L. Handen, Mark Mapstone, Melissa Petersen, Sharon J. Krinsky-Mchale, Christy L. Hom, Davneet Minhas, Weiquan Luo, Charles Laymon, Joseph H. Lee, Annie Cohen, Beau M. Ances, Adam M. Brickman, Margaret Pulsifer, H. Diana Rosas, Florencia Lai, Shahid H. Zaman, Elizabeth Head, Dana Tudorascu, Julie Price, Fredrick Schmitt, Bradley T. Christian, Ozioma Okonkwo, Sigan L. Hartley, Beau M. Ances, Howard F. Andrews, Karen Bell, Rasmus M. Birn, Adam M. Brickman

Neurology Faculty Publications

Objective: Adults with Down syndrome (DS) often show elevated systemic inflammation, but the association with obesity, aging, and Alzheimer's disease (AD) pathology is not well understood. Methods: Data were drawn from 188 nondemented adults with DS participating in the Alzheimer Biomarkers Consortium-DS (ABC-DS). Participants completed clinical assessments, blood draws, and neuroimaging. Plasma biomarkers included indicators of general, pro-, and anti-inflammation. Mixed linear models tested associations between BMI, age, PET-measured amyloid burden, and inflammatory biomarkers, adjusting for sex, trisomy type, and collection site. False discovery rate correction was applied. Results: The majority of the participants met criteria for obesity. Higher BMI …

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Using Clinical And Thrombus Characteristics To Predict The Etiology Of Ischemic Stroke, Graham A. Branscom, Carina Seah, Tannishtha Som, James Vicari, Alan R. Dabney, Selva Baltan, Farida Sohrabji, Keith Pennypacker, Keith B. Woodward, Benjamin I. Rapoport, Sol Schulman, Justin F. Fraser, Christopher P. Kellner Jul 2026

Using Clinical And Thrombus Characteristics To Predict The Etiology Of Ischemic Stroke, Graham A. Branscom, Carina Seah, Tannishtha Som, James Vicari, Alan R. Dabney, Selva Baltan, Farida Sohrabji, Keith Pennypacker, Keith B. Woodward, Benjamin I. Rapoport, Sol Schulman, Justin F. Fraser, Christopher P. Kellner

Neurology Faculty Publications

Background and purpose: Ischemic stroke comprises about 87% of all stroke cases in the US. 20% of these have a cardioembolic (CE) etiology, and 25% are still considered embolic strokes of undetermined sources (ESUS). ESUS strokes are associated with worse functional outcomes and survival rates, underscoring the need for understanding the clinical differences in stroke etiology. Methods: We analyzed the Investigation of Clot in Ischemic Stroke and Hematoma Evacuation (INSIGHT) registry (NCT04693767, https://clinicaltrials.gov/study/NCT04693767), which includes n=388 patients total (n=208 CE, n=142 AFIB, n=180 non-CE). We analyzed 123 data features, spanning across domains including demographics, past medical history, baseline blood lab …

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Sweet Potato Gene Clusters Control Anthocyanin Biosynthesis And Leaf Morphology, Dong An, Tiechen Shen, Shiyu Wu, Yanshen Li, Weijuan Fan, Mengxiao Yan, Yinghui Meng, Xinyi Wang, Ximing Xu, Zunfu Lv, Ling Yuan, Jun Yang, Guoquan Lu, Hongxia Wang Jul 2026

Sweet Potato Gene Clusters Control Anthocyanin Biosynthesis And Leaf Morphology, Dong An, Tiechen Shen, Shiyu Wu, Yanshen Li, Weijuan Fan, Mengxiao Yan, Yinghui Meng, Xinyi Wang, Ximing Xu, Zunfu Lv, Ling Yuan, Jun Yang, Guoquan Lu, Hongxia Wang

Plant and Soil Sciences Faculty Publications

Sweet potato (Ipomoea batatas) exhibits diversity in pigmentation and leaf morphology, yet the genetic architecture and regulatory organisation underlying these traits remain poorly resolved, particularly with respect to organ-specific control. We hypothesised that phenotypic variation is governed by clustered genetic modules comprising regulatory and structural genes operating in an organ-specific manner. To test this, we conducted genome-wide association studies (GWAS) using 4.6 million SNPs across 260 diverse accessions, integrated with transcriptomic, haplotype and functional analyses. GWAS identified two tandem clusters of MYB transcription factors on chromosome 5 as the primary regulators of leaf anthocyanin accumulation. Expression profiling, heterologous expression and …

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Hybrid Type 1 Randomized Controlled Trial Of Technology-Assisted Stepped Care Behavioral Health Intervention For Caregivers And Children Following Pediatric Traumatic Injury, Leigh E. Ridings, Kari N. Thomsen, Margaret A. Prentice, Ebonie Powell, Gabriela Becerra, Martina Mueller, Rochelle Hanson, Christian J. Streck, Peter Ehrlich, Linda Ewing-Cobbs, Meghan L. Marsac, Ryan Spurrier, Tatiana Davidson, Kenneth J. Ruggiero Jul 2026

Hybrid Type 1 Randomized Controlled Trial Of Technology-Assisted Stepped Care Behavioral Health Intervention For Caregivers And Children Following Pediatric Traumatic Injury, Leigh E. Ridings, Kari N. Thomsen, Margaret A. Prentice, Ebonie Powell, Gabriela Becerra, Martina Mueller, Rochelle Hanson, Christian J. Streck, Peter Ehrlich, Linda Ewing-Cobbs, Meghan L. Marsac, Ryan Spurrier, Tatiana Davidson, Kenneth J. Ruggiero

Psychiatry Faculty Publications

Pediatric traumatic injury (PTI) has substantial physical and emotional health impacts, sometimes resulting in hospitalization and/or the development of posttraumatic stress disorder (PTSD) and depression in children. Caregivers are a key source of support for children following PTI; however, many caregivers experience their own distress and psychological reactions following injury. The CAARE (Caregivers' Aid to Accelerate Recovery after pediatric Emergencies) model is a technology-assisted, stepped care intervention to support the emotional and behavioral recovery of preadolescent children hospitalized after PTI and their caregivers. The CAARE model seeks to provide a systematic, evidence-based screening and intervention procedure that is feasible to …

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Comparison Of The 1c2 Reference Filtered Cigar To The 1r6f Reference Filtered Cigarette, Amrita Machwe, Samuel B. Clark, Halle Harned, Tanvi Sawardekar, Stacey A. Slone, Huihua Ji, David K. Orren Jul 2026

Comparison Of The 1c2 Reference Filtered Cigar To The 1r6f Reference Filtered Cigarette, Amrita Machwe, Samuel B. Clark, Halle Harned, Tanvi Sawardekar, Stacey A. Slone, Huihua Ji, David K. Orren

Markey Cancer Center Faculty Publications

Introduction: Filtered cigars are a class of tobacco products that can be consumed similarly as conventional cigarettes. Here we have compared tobacco smoke condensates prepared from the 1C2 reference filtered cigar with those from the 1R6F reference cigarette with respect to effects on cell proliferation and viability and AhR-mediated gene expression. Methods: Tobacco smoke condensates were prepared using ISO, Health Canada Intense (HCI) or Cigar Smoking (CSR) regimens and certain HPHCs were measured. Cell proliferation and viability assays were performed on immortalized human bronchial or oral epithelial cell lines. AHR-mediated gene expression was measured using a mouse hepatoma cell line …

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Permanent Winter Hay-Feeding Stations Concentrate Soil Nutrients In Kentucky Pastures, Alan J. Franzluebbers, Jeffrey W. Lehmkuhler, Matt H. Poore, Arjun Kafle, Rodolfo Zentella, Tommy Yankey, S. Ray Smith, Gregory Halich Jul 2026

Permanent Winter Hay-Feeding Stations Concentrate Soil Nutrients In Kentucky Pastures, Alan J. Franzluebbers, Jeffrey W. Lehmkuhler, Matt H. Poore, Arjun Kafle, Rodolfo Zentella, Tommy Yankey, S. Ray Smith, Gregory Halich

Animal and Food Sciences Faculty Publications

Distribution of soil nutrients as a function of centralized winter hay-feeding stations can lead to inefficient nutrient utilization and environmental quality concerns, but distributions have not been adequately characterized across a diversity of soils. We investigated spatial distribution of soil nutrients and organic matter fractions on three farms with concrete feeding pads for winter hay feeding. Soils were silt loam at the Princeton and Oran Little Research Stations and silty clay loam and silty clay at the Eden Shale Farm in ≥20-year-old tall fescue (Lolium arundinaceum) pastures in Kentucky. An anticipated impact zone of 0.7–1.0 ha around the winter hay-feeding …

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Effect Of Level Of Nitrogen Fertilization Of Kentucky 31 Tall Fescue (Festuca Arundinacea Schreb.) On Brood-Cow Health, J A. Stuedemann, S R. Wilinson, H Ciordia, A B. Caudle Jun 2026

Effect Of Level Of Nitrogen Fertilization Of Kentucky 31 Tall Fescue (Festuca Arundinacea Schreb.) On Brood-Cow Health, J A. Stuedemann, S R. Wilinson, H Ciordia, A B. Caudle

IGC Proceedings (1977-2023)

Studies were conducted to assess the long-term effects of nitrogen (N) fertilization of tall fescue on cow-calf performance and health problems, including grass tetany, fat necrosis, gastrointestinal parasitism, and nitrate poisoning. Kentucky 31 tall fescue pastures fertilized at three levels of N were grazed with Angus cows at 0.4 ha/cow on a year-round basis. Fertilization levels in­cluded high N (667 and 0 kg N/ha/yr from broiler litter in 1968-1974 and 1975-1977, respectively); moderate N (134 and 224 kg N/ha/yr from ammonium nitrate [NH4N03] in 1969 and 1970-1977, respectively); and low N (84 and 74 kg N/ha/yr from NH4N03 in 1972 …

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Long-Term Feeding Of Corn Silage As The Sole Forage In Diets Of Lactating Dairy Cows, C H. Noller, N J. Moeller, C L. Rhykerd Jun 2026

Long-Term Feeding Of Corn Silage As The Sole Forage In Diets Of Lactating Dairy Cows, C H. Noller, N J. Moeller, C L. Rhykerd

IGC Proceedings (1977-2023)

The long-term feeding of corn silage as the sole forage to lactating dairy cows has had only limited success due to problems with production, reproduction, and health after one lactation. Consequently, a long-term study was begun in August 1975 with two groups of 19 cows, 15 2-year-old heifers, and 4 3-year-old cows assigned at random to each group as they calved. One group was fed a diet with corn silage as the sole forage and the other group a diet with a 50: 50 ratio of forage as corn silage (CS) and low-moisture alfalfa-orchardgrass ( AO) silage. Both rations contained …

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Endoplasmic Reticulum-Resident Α-Glucosidase Ii Drives Non-Small Cell Lung Cancer Progression Via Regulation Of Secretory Glycoproteins, Shike Wang, Na Ding, Angelo Chen, Derrick Cardin, Yuting Xu, Kate Grimley, William K. Russell, Jun Xu, Jonathan M. Kurie, Guan Yu Xiao, Xiaochao Tan Jun 2026

Endoplasmic Reticulum-Resident Α-Glucosidase Ii Drives Non-Small Cell Lung Cancer Progression Via Regulation Of Secretory Glycoproteins, Shike Wang, Na Ding, Angelo Chen, Derrick Cardin, Yuting Xu, Kate Grimley, William K. Russell, Jun Xu, Jonathan M. Kurie, Guan Yu Xiao, Xiaochao Tan

Markey Cancer Center Faculty Publications

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, yet its molecular drivers are not fully defined. Emerging evidence highlights the importance of tumor-stroma interactions mediated by secreted glycoproteins. However, the mechanisms by which cancer cells regulate the secretion of these protumorigenic proteins remain largely unknown. Endoplasmic reticulum-resident (ER-resident) N-glycan-processing enzymes regulate proper protein folding, a prerequisite for glycoproteins to exit the ER and undergo secretion. By evaluating their prognostic significance in lung tumors and conducting functional screening in lung cancer cells, we identify α-glucosidase II (α-Glc II) as a key regulator of NSCLC progression. α-Glc …

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Frontal Release Signs And Future Decline In Research Participants With Intact Cognition, Lauren G. Bojarski, Gregory A. Jicha, Elif Pinar Coskun, Frederick A. Schmitt, Linda Van Eldik, Erin L. Abner Jun 2026

Frontal Release Signs And Future Decline In Research Participants With Intact Cognition, Lauren G. Bojarski, Gregory A. Jicha, Elif Pinar Coskun, Frederick A. Schmitt, Linda Van Eldik, Erin L. Abner

Neurology Faculty Publications

Importance Frontal release signs (FRS) are primitive reflexes that regress with brain maturation and reappear in the setting of brain injury or neurodegeneration. Despite their association with dementia, the prognostic utility of this finding in the setting of early cognitive decline and preclinical disease is poorly understood. Objective To evaluate the association of FRS with future cognitive decline in research participants. Design, Setting, and Participants This cohort study examined the presence of FRS (from 2005-2024) among research cohort participants with intact cognition or mild impairment at study baseline. The study used single-center data collection of longitudinal research cohort data through …

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Research And Assessment Of Needs For Sign And Signal Maintenance, Megan White, Eric Green Jun 2026

Research And Assessment Of Needs For Sign And Signal Maintenance, Megan White, Eric Green

Kentucky Transportation Center Research Report

Kentucky Transportation Cabinet (KYTC) sign and signal crews have expressed multiple concerns related to compensation, expertise, and having the financial and personnel resources needed to help the agency comply with Manual on Uniform Traffic Control Devices (MUTCD) guidelines while continuing to perform routine job duties. Internal reorganizations and personnel changes have reduced staffing and budgets available to underwrite the activities of sign and signal crews even as workloads have remained steady or increased. To document the challenges facing sign and signal crews and associated engineering staff, Kentucky Transportation Center (KTC) researchers administered a statewide survey. Respondents gave their perspectives on …

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Building And Facility Asset Inventory Assessment And Maintenance, Catherine Keathley, Bethany Paris, Jon Wilcoxson Jun 2026

Building And Facility Asset Inventory Assessment And Maintenance, Catherine Keathley, Bethany Paris, Jon Wilcoxson

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) manages approximately 1,500 buildings statewide, including facilities such as office buildings, maintenance and equipment garages, and storage sheds. Because managing buildings and properties requires considerable effort, agency decision makers need reliable monitoring and management tools that generate and organize data which can be used to determine the best course of action for facility maintenance and replacement. In addition to assessing the Cabinet’s building inventory, this report advances recommendations to improve the collection, management, and reporting of facility-related data. Assessment of the inventory managed by KYTC included geolocation of all properties and the buildings therein. Once …

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Improving The Clinical Trial Landscape For Patients With Atypical Variants Of Alzheimer's Disease, Nick Corriveau-Lecavalier, Neus Falgàs, Deepti Putcha, Jonathan Graff-Radford, Keir X.X. Yong, Baayla D.C. Boon, Rosaleena Mohanty, Eric Westman, Colin Groot, David T. Jones, Lea T. Grinberg, Gil D. Rabinovici, Jennifer L. Whitwell, Liana G. Apostolova, Melissa E. Murray, Dustin B. Hammers, Suzanne E. Schindler, Inga Atonsdottir, Elizabeth K. Rhodus, Jonathan M. Schott, Ignacio Illán-Gala, Ogbuagu Chukwuanugo, Jorge J.Llibre Guerra, Ruth Peters, Erin L. Abner, Carla Abdelnour, Albert Lladó, Renaud La Joie Jun 2026

Improving The Clinical Trial Landscape For Patients With Atypical Variants Of Alzheimer's Disease, Nick Corriveau-Lecavalier, Neus Falgàs, Deepti Putcha, Jonathan Graff-Radford, Keir X.X. Yong, Baayla D.C. Boon, Rosaleena Mohanty, Eric Westman, Colin Groot, David T. Jones, Lea T. Grinberg, Gil D. Rabinovici, Jennifer L. Whitwell, Liana G. Apostolova, Melissa E. Murray, Dustin B. Hammers, Suzanne E. Schindler, Inga Atonsdottir, Elizabeth K. Rhodus, Jonathan M. Schott, Ignacio Illán-Gala, Ogbuagu Chukwuanugo, Jorge J.Llibre Guerra, Ruth Peters, Erin L. Abner, Carla Abdelnour, Albert Lladó, Renaud La Joie

Epidemiology and Environmental Health Faculty Publications

Patients with atypical variants of Alzheimer's disease (AD) often present at a younger age with predominantly non-amnestic impairments and a more aggressive disease course. Historically, individuals with atypical presentations have not been included in large-scale clinical trials, which typically focus on late-onset, sporadic amnestic-predominant AD. Consequently, treatment options and research efforts specific to atypical AD remain limited. The emergence of amyloid-targeting therapies that slow disease progression underscores these challenges, as evidence supporting their efficacy in early-onset amnestic and non-amnestic AD variants is scarce. This perspective article argues that atypical AD represents an excellent disease model for clinical trials and proposes …

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Transportability Analyses In Comparative Effectiveness Research, Blythe Adamson, Wei Liu, Stephen Duffield, Anouk Déruaz-Luyet, Dimitri Bennett, Montse Soriano Gabarró, Mehmet Burcu, Daniela Claudia Moga, Sarah Welby, Tianze Jiao, Xuerong Wen, Grammati Sarri Jun 2026

Transportability Analyses In Comparative Effectiveness Research, Blythe Adamson, Wei Liu, Stephen Duffield, Anouk Déruaz-Luyet, Dimitri Bennett, Montse Soriano Gabarró, Mehmet Burcu, Daniela Claudia Moga, Sarah Welby, Tianze Jiao, Xuerong Wen, Grammati Sarri

Epidemiology and Environmental Health Faculty Publications

The Problem: Transportability considerations are increasingly important to answer research questions in comparative effectiveness research (CER) to support the transfer of evidence on medicinal products across countries or settings. As drug development costs rise and healthcare systems and professionals face economic and resource pressures, leveraging existing data and evidence generated across borders or settings can improve efficiency and inform decisions in product development and decision-making (regulatory, health technology assessment [HTA] and clinical care). Differences in population characteristics, healthcare systems, and data availability, including coding discrepancies, may present significant challenges to the transportability of CER evidence. Without rigorous methodological approaches, the …

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The Polysubstance Assessment Tool, Amanda M. Bunting, Charles M. Cleland, S. Michaela Barratt, Brittany Griffin, Jaimee Williams, Carrie B. Oser, Joshua D. Lee, Jennifer Mcneely Jun 2026

The Polysubstance Assessment Tool, Amanda M. Bunting, Charles M. Cleland, S. Michaela Barratt, Brittany Griffin, Jaimee Williams, Carrie B. Oser, Joshua D. Lee, Jennifer Mcneely

Sociology Faculty Publications

Background and aims: There are currently no brief quantitative assessments that capture the drug patterns of people who engage in use of more than one drug on the same day or simultaneously. The current study examined the retest reliability, acceptability and feasibility of a new quantitative assessment to measure polysubstance use. Design: A tool for assessing simultaneous and same-day polysubstance behaviors, the polysubstance assessment tool (PAT) was developed in interviewer-administered and electronic self-administered formats. Participants were allocated 1:1 to receive either version of the PAT and returned one to three days later to repeat the assessment. Setting: New York City, …

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The Relationships Among Neighborhood Disadvantage, Mental Health And Developmental Disabilities Diagnoses, And Race/Ethnicity In A U.S. Urban Location, Deborah Winders Davis, Kahir Jawad, Yana B. Feygin, Michelle Stevenson, Bethany Wattles, Veronnie Faye Jones, Jennifer Porter, W. David Lohr, Jennifer Le Jun 2026

The Relationships Among Neighborhood Disadvantage, Mental Health And Developmental Disabilities Diagnoses, And Race/Ethnicity In A U.S. Urban Location, Deborah Winders Davis, Kahir Jawad, Yana B. Feygin, Michelle Stevenson, Bethany Wattles, Veronnie Faye Jones, Jennifer Porter, W. David Lohr, Jennifer Le

Biostatistics Faculty Publications

Childhood health disparities by race have been found. Neighborhood disadvantage, which may result from racism, may impact outcomes. The aim of the study is to describe the distribution of mental health (MH) and developmental disabilities (DD) diagnosis across Child Opportunity Index (COI) levels by race/ethnicity. A cross-sectional study using 2022 outpatient visit data for children < 18 years living in the Louisville Metropolitan Area (n = 115,738) was conducted. Multivariable logistic regression analyses examined the association between diagnoses and COI levels, controlling for sex and age. Almost 18,000 children (15.5%) had a MH or DD (7,905 [6.8%]) diagnosis. In each COI level, the prevalence of MH diagnosis was lower for non-Hispanic (N–H) Black than for N–H White children. In adjusted analyses, there were no significant associations between diagnoses and COI for non-White children for MH or DD diagnoses. The odds of receiving a MH [OR: 1.74 (95% CI: 1.62, 1.87)] and DD [OR: 1.69 (95% CI: 1.51, 1.88)] diagnosis were higher among N–H White children living in Very Low compared to Very High COI areas. Current findings suggest that COI does not explain disparities in diagnosis for non-White children. More research is needed to identify potential multi-level drivers such as other forms of racism. Identifying programs, policies, and interventions to reduce childhood poverty and link children and families to affordable, family-centered, quality community mental and physical health resources is needed to ensure that families can build trusting relationships with the providers while minimizing stigma.

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Missed Clinic Appointments For Human Papillomavirus-Related Oropharyngeal Cancer, John M. Vieth, Anthony A. Mangino, Melina J. Windon, Joseph Valentino Jun 2026

Missed Clinic Appointments For Human Papillomavirus-Related Oropharyngeal Cancer, John M. Vieth, Anthony A. Mangino, Melina J. Windon, Joseph Valentino

Biostatistics Faculty Publications

Background: Missing appointments delay treatment affecting patient outcomes and healthcare resource utilization. Adherence to scheduled appointments has not been studied in patients with HPV-related oropharyngeal squamous cell carcinoma (HPV-OPSCC). Methods: We collected data from 36,690,000 scheduled medical outpatient encounters at the University of Kentucky Health Care from 2012 to 2021. A total of 36,579 of these encounters were from 334 patients with HPV-OPSCC. We performed regression analysis of no-show appointments by demographics, tumor characteristics, and insurance factors. Results: The no-shows rate for appointments was significantly higher for the HPV-OPSCC cohort (4.6% vs. 2.2% p < 0.001). The HPV-OPSCC cohort missed 36% of their appointments. Black, Hispanic, younger, those who have ever smoked and patients with advanced tumor stage all had statistically significantly higher no-show rates (p < 0.01). Conclusions: Treatment delay impacts cancer treatment efficacy and no-show appointments burden medical systems. Further research into targeted interventions is needed to lower barriers for attending appointments.

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Provider And Patient Perspectives On The Diagnosis And Treatment Of Alzheimer's Disease, Philippe Amouyel, Sandrine Andrieu, Angela Bradshaw, Ralph C. Carmona, Magali Dumont, Lea Tenenholz Grinberg, Takeshi Iwatsubo, Oskar Hansson, Clifford R. Jack, Gregory A. Jicha, Simin Mahinrad, Eric Mcdade, Catherine J. Mummery, Ronald C. Petersen, Shelagh Robinson, Julie A. Schneider, Lenny Shellcross, Amanda G. Smith, Heather M. Snyder, Beth Tapply, Charlotte Teunissen, Wiesje M. Van Der Flier, Bruno Vellas, David Wallon, Jeff D. Williamson, Donna Wilcock, Maria C. Carrillo Jun 2026

Provider And Patient Perspectives On The Diagnosis And Treatment Of Alzheimer's Disease, Philippe Amouyel, Sandrine Andrieu, Angela Bradshaw, Ralph C. Carmona, Magali Dumont, Lea Tenenholz Grinberg, Takeshi Iwatsubo, Oskar Hansson, Clifford R. Jack, Gregory A. Jicha, Simin Mahinrad, Eric Mcdade, Catherine J. Mummery, Ronald C. Petersen, Shelagh Robinson, Julie A. Schneider, Lenny Shellcross, Amanda G. Smith, Heather M. Snyder, Beth Tapply, Charlotte Teunissen, Wiesje M. Van Der Flier, Bruno Vellas, David Wallon, Jeff D. Williamson, Donna Wilcock, Maria C. Carrillo

Neurology Faculty Publications

Since 2016, the Alzheimer's Association and the Fondation Alzheimer have hosted Global Alzheimer's Leadership Series (GoALS) global think tanks, with world-leading experts for innovative discussions to advance Alzheimer's disease (AD) research and care. The second GoALS think tank, held in June 2024 in Paris, focused on the relationship between biological changes and clinical manifestations of AD in the context of the evolving therapeutic landscape. Discussions spanned real-world experiences of providers, patients, and their families, theoretical considerations, and health system challenges. The lived experience perspective was central to these discussions. The importance of shared decision-making, clear and transparent communication, and the …

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Soybean Plant Population Density Recommendations Across The United States, Giovani Preza Fontes, Carrie Ortel, Emma Macham, David Moseley, Shawn Conley, Chad Lee, Mark A. Licht, Laura E. Lindsey, Haleigh J. Ortmeier-Clarke, Rachel Vann, Maninder P. Singh, Seth Naeve, Jeremy Ross, Jake Mcneal, Michael Plumblee, Shaun Casteel, Eros Francisco, Michael J. Mulvaney, Nicolas Cafaro La Menza, Andre Froes De Borja Reis, Daniela Carrijo, Emerson Nafziger Jun 2026

Soybean Plant Population Density Recommendations Across The United States, Giovani Preza Fontes, Carrie Ortel, Emma Macham, David Moseley, Shawn Conley, Chad Lee, Mark A. Licht, Laura E. Lindsey, Haleigh J. Ortmeier-Clarke, Rachel Vann, Maninder P. Singh, Seth Naeve, Jeremy Ross, Jake Mcneal, Michael Plumblee, Shaun Casteel, Eros Francisco, Michael J. Mulvaney, Nicolas Cafaro La Menza, Andre Froes De Borja Reis, Daniela Carrijo, Emerson Nafziger

Plant and Soil Sciences Faculty Publications

Rising production costs and declining commodity prices have compelled farmers to reassess their input and management strategies. Soybean [Glycine max (L.) Merr] seed costs, in particular, have continued to increase due to advances in biotechnology, higher-yielding germplasm, and available seed treatments, accounting for 32–35% of the total operational expenses in current soybean production systems. Optimizing seeding rate is therefore one area of consideration for improving profitability and maximizing return on investment. However, soybean yield response to plant population density is influenced by the combination of several factors, including water availability, temperature, radiation interception, planting practices, and crop growth and development. …

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School Renewal And School Well-Being, Jianping Shen, John Lane, Patricia Reeves, Siche Feng, Xin Ma Jun 2026

School Renewal And School Well-Being, Jianping Shen, John Lane, Patricia Reeves, Siche Feng, Xin Ma

Educational, School, and Counseling Psychology Faculty Publications

In this longitudinal case study, we examined school well-being during the change process. We operationalized the change process as the school renewal model and viewed school well-being from the perspective of the PERMA (positive emotion, engagement, relationships, meaning, and accomplishment) model. We found that all elements of the PERMA model were manifested in the school renewal process and that the school renewal process was not dominated solely by conflict and tension, as the literature typically suggests about the change process. The findings of the study suggest the possibility of reframing tension as productive rather than detrimental in the school renewal …

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Volumetric Differences Of Thalamic Nuclei Are Associated With Posttrauma Psychopathology, Nick Steele, Ahmed Hussain, C. Lexi Baird, Courtney C. Haswell, Delin Sun, Leonel Rangel-Jimenez, Chadi G. Abdallah, Michael Angstadt, Geoffrey May, Hannah Berg, Jennifer U. Blackford, Josh M. Cisler, Judith K. Daniels, Nicholas D. Davenport, Richard J. Davidson, Maria Densmore, Seth G. Disner, Wissam El-Hage, Amit Etkin, Negar Fani, Jessie L. Frijling, Evan M. Gordon, Daniel W. Grupe, Ryan J. Herringa, Anna R. Hudson, Neda Jahanshad, Tanja Jovanovic, Anthony King, Saskia B.J. Koch, Ruth Lanius, Amit Lazarov, Gen Li Jun 2026

Volumetric Differences Of Thalamic Nuclei Are Associated With Posttrauma Psychopathology, Nick Steele, Ahmed Hussain, C. Lexi Baird, Courtney C. Haswell, Delin Sun, Leonel Rangel-Jimenez, Chadi G. Abdallah, Michael Angstadt, Geoffrey May, Hannah Berg, Jennifer U. Blackford, Josh M. Cisler, Judith K. Daniels, Nicholas D. Davenport, Richard J. Davidson, Maria Densmore, Seth G. Disner, Wissam El-Hage, Amit Etkin, Negar Fani, Jessie L. Frijling, Evan M. Gordon, Daniel W. Grupe, Ryan J. Herringa, Anna R. Hudson, Neda Jahanshad, Tanja Jovanovic, Anthony King, Saskia B.J. Koch, Ruth Lanius, Amit Lazarov, Gen Li

Psychiatry Faculty Publications

Background: Previous investigations of whole thalamus and thalamic nuclei volumes in posttrauma psychopathology have been sparse and limited in scope and have yielded inconsistent results. To address this, volumetric estimates of whole thalamus and thalamic nuclei were obtained from structural brain magnetic resonance imaging scans from 2058 participants across 20 worldwide sites in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Posttraumatic Stress Disorder (PTSD) working group. Methods: Thalamic volumes were compared in trauma-exposed participants with PTSD (n = 238), major depressive disorder (MDD) (n = 184), and comorbid PTSD+MDD (n = 618) and in trauma-exposed control participants (n …

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Alterations Of Cerebral Extracellular Vesicle Microrna Profiling Potentially Disrupts Brain Homeostasis Following Myocardial Infarction, Md Monowarul Islam, Shouyi Liang, Lijun Sun, Guoku Hu, Neha Dhyani, Lie Gao, Tara L. Rudebush, Xue Xu, Jinpeng Liu, Irving H. Zucker, Changhai Tian Jun 2026

Alterations Of Cerebral Extracellular Vesicle Microrna Profiling Potentially Disrupts Brain Homeostasis Following Myocardial Infarction, Md Monowarul Islam, Shouyi Liang, Lijun Sun, Guoku Hu, Neha Dhyani, Lie Gao, Tara L. Rudebush, Xue Xu, Jinpeng Liu, Irving H. Zucker, Changhai Tian

Markey Cancer Center Faculty Publications

Cognitive impairment (CI) is prevalent among heart failure (HF) patients. Although the brain injury in HF is multifactorial, oxidative stress and neuroinflammation are common pathological features of neurological disorders and are increasingly recognized as key mechanisms underlying CI. Extracellular vesicles (EVs) are well-established mediators of biological signaling in myocardial function and are widely recognized for transporting a variety of microRNAs. However, whether myocardial injury alters the miRNA profiles of brain EVs, potentially contributing to cognitive impairment (CI) by disrupting brain homeostasis, remains poorly understood. Using a rodent myocardial infarction (MI) model, we isolated brain EVs and characterized their miRNA profiling …

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Cardioprotective Effects Of 1,3 Butanediol In Masld Via Reversal Of Cardiac Lipid Accumulation And Suppression Of Cardiac Fibrosis, Olufunto O. Badmus, Landon D. Parrow, Karis E. Mcgowen, La Brenda Bell, Jennifer R. Greer, Marcela De Carvalho Cruz, Terry D. Hinds, David E. Stec Jun 2026

Cardioprotective Effects Of 1,3 Butanediol In Masld Via Reversal Of Cardiac Lipid Accumulation And Suppression Of Cardiac Fibrosis, Olufunto O. Badmus, Landon D. Parrow, Karis E. Mcgowen, La Brenda Bell, Jennifer R. Greer, Marcela De Carvalho Cruz, Terry D. Hinds, David E. Stec

Markey Cancer Center Faculty Publications

Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly associated with the development of cardiovascular disease (CVD); however, the mechanisms responsible are currently unknown. We have developed a model of MASLD due to the loss of hepatocyte peroxisome proliferator-activated receptor α (PPARαHEPKO). We found that plasma beta-hydroxybutyrate (BHOB) levels were significantly reduced in PPARαHEPKO mice and aimed to investigate the therapeutic potential of restoring BHOB levels in the development of CVD in these mice. Thirty-week-old PPARαHEPKO and control PPARαFL/FL mice were randomized to receive 1,3 butanediol (1,3-BDO), a precursor of BHOB, in drinking water for 6 …

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