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Stigma And Efficacy Beliefs Regarding Opioid Use Disorder Treatment And Naloxone In Communities Participating In The Healing Communities Study Intervention, Nicky Lewis, Barry Eggleston, Redonna K. Chandler, Dawn Goddard-Eckrich, Jamie E. Luster, Dacia Beard, Emma Rodgers, Rouba A. Chahine, Philip M. Westgate, Shoshana N. Benjamin, Janae Holloway, Thomas Clarke, R. Craig Lefebvre, Michael D. Stein, Donald W. Helme, Jennifer Reynolds, Sharon L. Walsh, Darcy Freedman, Nabila El-Bassel, Kara Stephens, Anita Silwal, Michelle R. Lofwall, Janet E. Childerhose, Hilary L. Surratt, Brooke N. Crockett, Amy L. Farmer, James L. David, Laura Fanucchi, Judy Harness, Ben Wilburn, Kelli Bursey, Kristin Mattson, Sarah Mann, Rebecca D. Jackson, Aimee Shadwick, Katherine Calver, Deborah Chassler, Jennifer Kimball, Nancy Regan, Jeffrey H. Samet, Rachel Sword-Cruz, Michael D. Slater Jan 2024

Stigma And Efficacy Beliefs Regarding Opioid Use Disorder Treatment And Naloxone In Communities Participating In The Healing Communities Study Intervention, Nicky Lewis, Barry Eggleston, Redonna K. Chandler, Dawn Goddard-Eckrich, Jamie E. Luster, Dacia Beard, Emma Rodgers, Rouba A. Chahine, Philip M. Westgate, Shoshana N. Benjamin, Janae Holloway, Thomas Clarke, R. Craig Lefebvre, Michael D. Stein, Donald W. Helme, Jennifer Reynolds, Sharon L. Walsh, Darcy Freedman, Nabila El-Bassel, Kara Stephens, Anita Silwal, Michelle R. Lofwall, Janet E. Childerhose, Hilary L. Surratt, Brooke N. Crockett, Amy L. Farmer, James L. David, Laura Fanucchi, Judy Harness, Ben Wilburn, Kelli Bursey, Kristin Mattson, Sarah Mann, Rebecca D. Jackson, Aimee Shadwick, Katherine Calver, Deborah Chassler, Jennifer Kimball, Nancy Regan, Jeffrey H. Samet, Rachel Sword-Cruz, Michael D. Slater

Biostatistics Faculty Publications

Background The HEALing Communities Study (HCS) included health campaigns as part of a community-engaged intervention to reduce opioid-related overdose deaths in 67 highly impacted communities across Kentucky, Massachusetts, New York, and Ohio. Five campaigns were developed with community input to provide information on opioid use disorder (OUD) and overdose prevention, reduce stigma, and build demand for evidence-based practices (EBPs). An evaluation examined the recognition of campaign messages about naloxone and whether stigma and efficacy beliefs regarding OUD treatment and naloxone changed in HCS intervention communities.

Methods Data were collected through surveys offered on Facebook/Instagram to members of communities participating in …


A Case Study On Variations In Network Structure And Cross- Sector Alignment In Two Local Systems Serving Pregnant And Parenting Women In Recovery, Liza M. Creel, Yana Feygin, Madeline Shipley, Deborah Winders Davis, Tiffany Cole Hall, Chaly Downs, Stephanie Hoskins, Natalie Pasquenza, Scott D. Duncan Jan 2024

A Case Study On Variations In Network Structure And Cross- Sector Alignment In Two Local Systems Serving Pregnant And Parenting Women In Recovery, Liza M. Creel, Yana Feygin, Madeline Shipley, Deborah Winders Davis, Tiffany Cole Hall, Chaly Downs, Stephanie Hoskins, Natalie Pasquenza, Scott D. Duncan

Biostatistics Faculty Publications

Objective: To describe network structure and alignment across organizations in healthcare, public health, and social services sectors that serve pregnant and parenting women with substance use disorder (SUD) in an urban and a rural community.

Data Sources and Study Settings: Two community networks, one urban and one rural with each including a residential substance use treatment program, in Kentucky during 2021.

Study Design: Social network analysis measured system collaboration and cross-sector alignment between healthcare, public health, and social services organizations, applying the Framework for Aligning Sectors. To understand the alignment and structure of each network, we measured network density overall …


Higher First 30-Day Dose Of Buprenorphine For Opioid Use Disorder Treatment Is Associated With Decreased Mortality, Feitong Lei, Michelle R. Lofwall, Jana Mcanich, Reuben Adatorwovor, Emily Slade, Patricia R. Freeman, Daniela Moga, Nabarun Dasgupta, Sharon L. Walsh, Rachel Vickers-Smith, Svetla Slavova Jan 2024

Higher First 30-Day Dose Of Buprenorphine For Opioid Use Disorder Treatment Is Associated With Decreased Mortality, Feitong Lei, Michelle R. Lofwall, Jana Mcanich, Reuben Adatorwovor, Emily Slade, Patricia R. Freeman, Daniela Moga, Nabarun Dasgupta, Sharon L. Walsh, Rachel Vickers-Smith, Svetla Slavova

Biostatistics Faculty Publications

Objective: Buprenorphine is a medication for opioid use disorder that reduces mortality. This study aims to investigate the less well-understood relationship between the dose in the early stages of treatment and the subsequent risk of death.

Methods: We used Kentucky prescription monitoring data to identify adult Kentucky residents initiating transmucosal buprenorphine medication for opioid use disorder (January 2017 to November 2019). Average daily buprenorphine dose for days covered in the first 30 days of treatment was categorized as ≤8 mg, >8 to ≤16 mg, and >16 mg. Patients were followed for 365 days after the first 30 days of buprenorphine …


Rural And Urban Clinician Views On Covid- 19’S Impact On Substance Use Treatment For Individuals On Community Supervision In Kentucky, Carrie B. Oser, Maria Rockett, Sebastian Otero, Evan Joseph Batty, Marisa Booty, Rachel Gressick, Michele Staton, Hannah K. Knudsen Jan 2024

Rural And Urban Clinician Views On Covid- 19’S Impact On Substance Use Treatment For Individuals On Community Supervision In Kentucky, Carrie B. Oser, Maria Rockett, Sebastian Otero, Evan Joseph Batty, Marisa Booty, Rachel Gressick, Michele Staton, Hannah K. Knudsen

Sociology Faculty Publications

Background The COVID-19 pandemic produced system-level changes within the criminal legal system and community-based substance use disorder (SUD) treatment system with impacts on recovery efforts. This study examines rural and urban clinicians’ perspectives of COVID-19 on SUD treatment delivery for people on community supervision.

Methods Virtual qualitative interviews were conducted between April and October 2020 with 25 community supervision clinicians employed by Kentucky’s Department of Corrections (DOC), who conduct assessments and facilitate community-based treatment linkages for individuals on probation or parole. Transcripts were analyzed in NVivo using directed content analysis methods.

Results Clinicians were predominantly white (92%) and female (88%) …


Cultural Predictors Of Self-Esteem Among Black Women With Criminal Justice Involvement And Herpes Simplex Virus, Natalie Malone, Jardin N. Dogan-Dixon, Shemeka Thorpe, Shawndaya S. Thrasher, Paris Wheeler, Danelle Stevens-Watkins, Carrie B. Oser Jan 2024

Cultural Predictors Of Self-Esteem Among Black Women With Criminal Justice Involvement And Herpes Simplex Virus, Natalie Malone, Jardin N. Dogan-Dixon, Shemeka Thorpe, Shawndaya S. Thrasher, Paris Wheeler, Danelle Stevens-Watkins, Carrie B. Oser

Sociology Faculty Publications

Black women have disproportionately alarming HSV-2 infection rates yet receive little attention in sexual health literature. Using a strengths-based resilience framework, this study sought to determine culturally relevant protective predictors of self-esteem for Black women who are justice-involved and have HSV-2. The authors conducted secondary data analysis on data from the “Black Women in the Study of Epidemics (B-WISE) Project,” a longitudinal prospective study investigating health disparities and health services utilization among Black women with justice involvement. At baseline, N = 151 Black women with HSV-2 who were incarcerated or on probation completed survey measures assessing selfesteem, ethnic identity affirmation …


The State Of Coaching Of Staff In Licensed Childcare Centers, Kimberly Copeland Jan 2024

The State Of Coaching Of Staff In Licensed Childcare Centers, Kimberly Copeland

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

This study aimed to explore the coaching experiences of childcare staff working in licensed childcare centers by using an online survey. The survey questions sought to determine whether childcare staff had received coaching in the past 12 months, the sources of that coaching, its frequency and method of coaching, the topics covered, and the staff's perception of job-related coaching. Data from 52 participants reveals that: 92% of childcare staff have received job-related coaching from internal sources; 40% have received coaching from external sources. Most coaching occurs “In person in the classroom” and the largest percentage of coaching is delivered on …


Precision Application Of Water To Equine Racing Surfaces, Sydney Rae Cannon Jan 2024

Precision Application Of Water To Equine Racing Surfaces, Sydney Rae Cannon

Theses and Dissertations--Biosystems and Agricultural Engineering

As the horseracing industry has come under more scrutiny as of late, horse and rider safety has become a priority. The best was to keep a rider safe is to keep them on their horse, and the best way to do that is to keep the horse upright. This all comes down to consistency both between tracks and across a single track. The most important method of managing track consistency is through moisture content. This study examined how track design can impact moisture application, how moisture content can impact the surface material, and what design elements can be implemented to …


Pulse-Width Modulation Spray System Performance And Development Of A Novel System To Optimize Spray Use Efficacy, Prashanta Pokharel Jan 2024

Pulse-Width Modulation Spray System Performance And Development Of A Novel System To Optimize Spray Use Efficacy, Prashanta Pokharel

Theses and Dissertations--Biosystems and Agricultural Engineering

The overarching objective of this research was to enhance our understanding of pulse width modulation (PWM) based nozzle control system and develop an intelligent nozzle control system for agricultural spray applications. This dissertation focused on measuring and analyzing the transient nozzle pressure characteristics and performance under PWM control. Additionally, it explored the development of an innovative multi-degree-of-freedom (DOF) nozzle control system for precise chemical applications in specialty crop systems.

The pressure dynamics of a PWM system were studied by developing an instrumentation system capable of operating a solenoid valve and recording pressure signals. A nozzle body and two manifolds of …


Caught In The Crosshairs Of Educational Reform: How Teacher Labor Markets Respond To Polarized Education Policies, Danielle Duffy Chipman Jan 2024

Caught In The Crosshairs Of Educational Reform: How Teacher Labor Markets Respond To Polarized Education Policies, Danielle Duffy Chipman

Theses and Dissertations--Public Policy and Administration

Since the passage of No Child Left Behind (NCLB) teachers have been caught in the crosshairs of political debates about education policy (Davis, 2014; EPE Research Center, 2013a; Steiner & Woo, 2021; Woo et al., 2022; Zubrzycki, 2016). As political polarization between parties increased in the 2000s, debates about education policy became more acrimonious impacting teachers’ work lives (Heltzel & Laurin, 2020; Iyengar, 2021; Layman et al., 2006). The topic of these debates ranges from curriculum changes such as Common Core and Critical Race Theory (CTR), school shootings and safety, battles over school choice and voucher programs, teacher activism about …


Extracting Social Network Model Parameters From Social Science Literature, Isaac Batts Jan 2024

Extracting Social Network Model Parameters From Social Science Literature, Isaac Batts

Theses and Dissertations--Computer Science

When looking at computer modeling of social situations, much of the social science literature does not include ready-to-use statistics or parameters to be included in a social model. I explore studies related to speaking about racism (and other forms of bias), and interventions designed to diminish the occurrence of biased behavior, and use those readings to synthesize plausible parameters for a social computer model.


Inflammation And Tumor Progression: The Differential Impact Of Saa In Breast Cancer Models, Daniel Wilhelm Olivier, Carla Eksteen, Manisha Du Plessis, Louis De Jager, Lize Engelbrecht, Nathaniel Wade Mcgregor, Preetha Shridas, Frederick C. De Beer, Willem J. S. De Villiers, Etheresia Pretorius, Anna-Mart Engelbrecht Jan 2024

Inflammation And Tumor Progression: The Differential Impact Of Saa In Breast Cancer Models, Daniel Wilhelm Olivier, Carla Eksteen, Manisha Du Plessis, Louis De Jager, Lize Engelbrecht, Nathaniel Wade Mcgregor, Preetha Shridas, Frederick C. De Beer, Willem J. S. De Villiers, Etheresia Pretorius, Anna-Mart Engelbrecht

Saha Cardiovascular Research Center Faculty Publications

Background: Previous research has shown that the Serum Amyloid A (SAA) protein family is intricately involved in inflammatory signaling and various disease pathologies. We have previously demonstrated that SAA is associated with increased colitis disease severity and the promotion of tumorigenesis. However, the specific role of SAA proteins in breast cancer pathology remains unclear. Therefore, we investigated the role of systemic SAA1 and SAA2 (SAA1/2) in a triple-negative breast cancer mouse model.

Methods: Syngeneic breast tumors were established in wild-type mice, and mice lacking the SAA1/2 (SAADKO). Subsequently, tumor volume was monitored, species survival determined, the inflammatory profiles of mice …


Transient Interactions Modulate The Affinity Of Nf-Κb Transcription Factors For Dna, Tianjie Li, Shandy Shahabi, Tapan Biswas, Oleg V. Tsodikov, Wenfei Pan, De-Bin Huang, Vivien Ya-Fan Wang, Yi Wang, Gourisankar Ghosh Jan 2024

Transient Interactions Modulate The Affinity Of Nf-Κb Transcription Factors For Dna, Tianjie Li, Shandy Shahabi, Tapan Biswas, Oleg V. Tsodikov, Wenfei Pan, De-Bin Huang, Vivien Ya-Fan Wang, Yi Wang, Gourisankar Ghosh

Biology Faculty Publications

The dimeric nuclear factor kappa B (NF- κB) transcription factors (TFs) regulate gene expression by binding to a variety of κB DNA elements with conserved G:C-rich flanking sequences enclosing a degenerate central region. Toward defining mechanistic principles of affinity regulated by degeneracy, we observed an unusual dependence of the affinity of RelA on the identity of the central base pair, which appears to be noncontacted in the complex crystal structures. The affinity of κB sites with A or T at the central position is ~10- fold higher than with G or C. The crystal structures of neither the complexes nor …


The Integrated Behavioral Model Of Mental Health Help Seeking (Ibm-Hs): A Health Services Utilization Theory Of Planned Behavior For Accessing Care, Joseph H. Hammer, David L. Vogel, Patrick R. Grzanka, Nayeon Kim, Brian T. Keum, Claire Adams, Sarah A. Wilson Jan 2024

The Integrated Behavioral Model Of Mental Health Help Seeking (Ibm-Hs): A Health Services Utilization Theory Of Planned Behavior For Accessing Care, Joseph H. Hammer, David L. Vogel, Patrick R. Grzanka, Nayeon Kim, Brian T. Keum, Claire Adams, Sarah A. Wilson

Chemical and Materials Engineering Faculty Publications

This article introduces the integrated behavioral model of mental health help seeking (IBM-HS), a theoretical model for understanding the constructs (e.g., systemic, predisposing, and enabling factors; mental health literacy; illness perceptions; perceived need; stigma; shame; perceived benefits, motivation) that influence people’s decision making around seeking professional mental health care and their ultimate access to formal treatment. The IBM-HS is a help-seeking-specific adaptation of the empirically supported integrated behavioral model and integrative model, which are themselves evolutions of the theory of planned behavior and theory of reasoned action. The IBM-HS posits that help-seeking determinants (e.g., structural forces; cultural influences; past help-seeking …


Disorganization Of Actin Within The Shafts Of Stereocilia Is A Key Difference Between Temporary And Permanent Noise-Induced Hearing Loss (Nihl), Shadan Hadi Jan 2024

Disorganization Of Actin Within The Shafts Of Stereocilia Is A Key Difference Between Temporary And Permanent Noise-Induced Hearing Loss (Nihl), Shadan Hadi

Theses and Dissertations--Physiology

During sound stimulation, mechanosensory stereocilia of the auditory hair cell pivot around their bases, where their actin cores become denser and form rootlets protruding into the cuticular plate. It is believed that actin-based cuticular plate provides a stable mechanical support for stereocilia, while rootles are responsible for their pivotal flexibility and life-long resilience to mechanical stimuli. Not surprisingly, damage to the stereocilia bundles is known as a hallmark of permanent noise-induced hearing loss (NIHL). Yet, despite decades of NIHL studies, it is still unknown which ultrastructural changes in the stereocilia bundles are evoked directly by mechanical overstimulation.

Here, we explored …


Differential Effects Of Traumatic Brain Injury On Preinjury And Postinjury Born Hippocampal Neural Precursor Cells, Hannah Downing Jan 2024

Differential Effects Of Traumatic Brain Injury On Preinjury And Postinjury Born Hippocampal Neural Precursor Cells, Hannah Downing

Theses and Dissertations--Physiology

Moderate contusive traumatic brain injury (TBI) results in neuronal cell death in the cortex as well as cell death and damage in underlying structures, including the hippocampus. The hippocampus is critically involved in learning and memory and is one of two regions in the brain capable of undergoing neurogenesis throughout adulthood. Adult hippocampal neurogenesis is a complex sequence of events necessary for a neural progenitor cell (NPC) to differentiate into a mature granule cell neuron located in the granule cell layer of the dentate gyrus. TBI results in a preferential loss of immature neurons in the granule cell layer of …


Profiling The Molecular And Clinical Landscape Of Glioblastoma Utilizing The Oncology Research Information Exchange Network Brain Cancer Database, Alexandra N. Demetriou, Frances Chow, David W. Craig, Michelle G. Webb, D. Ryan Ormond, James Battiste, Arnab Chakravarti, Howard Colman, John L. Villano, Bryan P. Schneider, James K. C. Liu, Michelle L. Churchman, Gabriel Zada Jan 2024

Profiling The Molecular And Clinical Landscape Of Glioblastoma Utilizing The Oncology Research Information Exchange Network Brain Cancer Database, Alexandra N. Demetriou, Frances Chow, David W. Craig, Michelle G. Webb, D. Ryan Ormond, James Battiste, Arnab Chakravarti, Howard Colman, John L. Villano, Bryan P. Schneider, James K. C. Liu, Michelle L. Churchman, Gabriel Zada

Markey Cancer Center Faculty Publications

Background. Glioblastoma exhibits aggressive growth and poor outcomes despite treatment, and its marked var- iability renders therapeutic design and prognostication challenging. The Oncology Research Information Exchange Network (ORIEN) database contains complementary clinical, genomic, and transcriptomic profiling of 206 glio- blastoma patients, providing opportunities to identify novel associations between molecular features and clinical outcomes.

Methods. Survival analyses were performed using the Logrank test, and clinical features were evaluated using Wilcoxon and chi-squared tests with q-values derived via Benjamini-Hochberg correction. Mutational analyses util- ized sample-level enrichments from whole exome sequencing data, and statistical tests were performed using the one-sided Fisher Exact test …


Endosymbiont Diversity Across Native And Invasive Brown Widow Spider Populations, Monica A. Mowery, Laura Cecilia Rosenwald, Eric G. Chapman, Yael Lubin, Michal Segoli, Thembile Khoza, Robin Lyle, Jennifer A. White Jan 2024

Endosymbiont Diversity Across Native And Invasive Brown Widow Spider Populations, Monica A. Mowery, Laura Cecilia Rosenwald, Eric G. Chapman, Yael Lubin, Michal Segoli, Thembile Khoza, Robin Lyle, Jennifer A. White

Entomology Faculty Publications

The invasive brown widow spider, Latrodectus geometricus (Araneae: Theridiidae), has spread in multiple locations around the world and, along with it, brought associated organisms such as endosymbionts. We investigated endosymbiont diversity and prevalence across putative native and invasive populations of this spider, predicting lower endosymbiont diversity across the invasive range compared to the native range. First, we characterized the microbial community in the putative native (South Africa) and invasive (Israel and the United States) ranges via high throughput 16S sequencing of 103 adult females. All specimens were dominated by reads from only 1–3 amplicon sequence variants (ASV), and most individuals …


N(Alpha)-Acetyltransferase 40-Mediated Histone Acetylation Plays An Important Role In Ecdysone Regulation Of Metamorphosis In The Red Flour Beetle, Tribolium Castaneum, Sharath Chandra Gaddelapati, Smitha George, Anilkumar Moola, Karthi Sengodan, Subba Reddy Palli Jan 2024

N(Alpha)-Acetyltransferase 40-Mediated Histone Acetylation Plays An Important Role In Ecdysone Regulation Of Metamorphosis In The Red Flour Beetle, Tribolium Castaneum, Sharath Chandra Gaddelapati, Smitha George, Anilkumar Moola, Karthi Sengodan, Subba Reddy Palli

Entomology Faculty Publications

Histone acetylation, a crucial epigenetic modification, is governed by histone acetyltransferases (HATs), that regulate many biological processes. Functions of HATs in insects are not well understood. We identified 27 HATs and determined their functions using RNA interference (RNAi) in the model insect, Tribolium castaneum. Among HATs studied, N-alpha-acetyltransferase 40 (NAA40) knockdown caused a severe phenotype of arrested larval development. The steroid hormone, ecdysone induced NAA40 expression through its receptor, EcR (ecdysone receptor). Interestingly, ecdysone-induced NAA40 regulates EcR expression. NAA40 acetylates histone H4 protein, associated with the promoters of ecdysone response genes: EcR, E74, E75, and HR3, and causes an increase …


The Impact Of Measure 110 On Fatal Overdoses, Property And Violent Crime In Oregon, Hannah Mercado Jan 2024

The Impact Of Measure 110 On Fatal Overdoses, Property And Violent Crime In Oregon, Hannah Mercado

MPA/MPP/MPFM Capstone Projects

In November 2020, the Drug Addiction Treatment and Recovery Act (also known as Measure 110) was passed in Oregon with the purpose to provide access to treatment and recovery services available to anyone who may need to utilize them, while focusing on a health-oriented approach towards substance use disorder (SUD) across the state through the removal of low-level drug possession criminal penalties (Oregon Health Authority, n.d.). Historically, Oregon has consistently had some of the highest rates of substance use in the U.S., making this a pertinent issue which was addressed through the implementation of Measure 110. Citing a critical need …


Government Grant Receipts And Revenue Volatility: A Correlational Investigation Of Medium-Sized Arts Organizations, Carly Colvin Jan 2024

Government Grant Receipts And Revenue Volatility: A Correlational Investigation Of Medium-Sized Arts Organizations, Carly Colvin

MPA/MPP/MPFM Capstone Projects

Minimal revenue volatility has been shown to enable more accurate planning by nonprofit managers and contribute to nonprofit financial sustainability. The volatility of government revenues, a major income source for nonprofit organizations, is not a well-researched topic. This capstone presents correlational tests to study the relationship between government grant receipts and revenue volatility within medium-sized nonprofit arts organizations in California. In addition, a data compilation methodology is tested and documented to enable future research. The results do not show a correlation between receipt of government grants and revenue volatility. The ensuing considerations for nonprofit managers along with areas for future …


University Of Kentucky Healthcare Community Engagement Program Strategic Plan, Madison Fyffe Jan 2024

University Of Kentucky Healthcare Community Engagement Program Strategic Plan, Madison Fyffe

MPA/MPP/MPFM Capstone Projects

Strategic planning is an essential tool in providing direction to an organization through analysis of its current state and ideal future, and development of strategic goals. The University of Kentucky HealthCare’s community engagement program is a robust program within the department of Brand Strategy, tasked with serving all 120 Kentucky counties and over 150 local, state, and national organizations through health education, event sponsorship, and promotional resources. In its current state, a strategic plan to guide and track performance does not exist. This capstone aims to develop a strategic plan through the assessment of strategic planning theory, stakeholder analysis, and …


Employer Incentivized Cancer Screenings In Kentucky: A Case Study, Addison Dumes, Sophia Freeman, Megan Latiff Jan 2024

Employer Incentivized Cancer Screenings In Kentucky: A Case Study, Addison Dumes, Sophia Freeman, Megan Latiff

MPA/MPP/MPFM Capstone Projects

Kentucky has some of the highest mortality rates for colon, breast, cervical and lung cancer in the United States, according to the Center of Disease Control. Our Client, The Foundation for a Healthy Kentucky, is seeking to lower these rates by increasing employer driven cancer screenings. Previous studies show many states have been successful in implementing programs to motivate employees to participate in preventative screenings. Through individual interviews with Kentucky employers, this study aims to answer what factors affect the best practices and perceived barriers amongst employers with health and wellness programs to increase the rate of preventative breast, cervical, …


Impact Of The Availability And Affordability Of Childcare On The Economy, Valentina Osunmade, Cameron French Jan 2024

Impact Of The Availability And Affordability Of Childcare On The Economy, Valentina Osunmade, Cameron French

MPA/MPP/MPFM Capstone Projects

Kentucky's workforce participation rates are among the lowest in the nation, thus underscoring the urgent need to strengthen and sustain its workforce (Aull, 2023). One significant barrier for many families in the workforce is the lack of accessibility and affordability of childcare. The Child Care Assistance Program (CCAP) in Kentucky aims to alleviate this burden for low-income families. Despite the program's importance, no prior study has examined the direct impact of CCAP enrollment on workforce participation in Kentucky. This research addresses this gap by conducting a multiple regression analysis using aggregate data from the Kentucky Center for Statistics, the US …


Lexington Black Prosperity Initiative: Addressing Lexington’S Equity Gap, Kinsleigh Smith, Jason Schubert Jan 2024

Lexington Black Prosperity Initiative: Addressing Lexington’S Equity Gap, Kinsleigh Smith, Jason Schubert

MPA/MPP/MPFM Capstone Projects

The equity gap between Black Americans and white Americans is a persistent social issue. This equity gap presents itself in a variety of measures – wealth accumulation, homeownership, healthcare, educational achievement, financial stability, and more. Locally, the Lexington Black Prosperity Initiative, a program of the Blue Grass Community Foundation, is primarily focused on strengthening Lexington’s Black community and closing this equity gap. The initiative was established in 2020. As the Lexington Black Prosperity Initiative enters its fourth year of operations, they are seeking to expand their reach within the community by enacting long-lasting and sustainable programs that will work to …


City Beautification And Homelessness: Differing Priorities Of Cities Considered Beautiful And Ugly, Katia Davis Jan 2024

City Beautification And Homelessness: Differing Priorities Of Cities Considered Beautiful And Ugly, Katia Davis

MPA/MPP/MPFM Capstone Projects

The downtown area of a city is often considered the economic hub where people come together as a society to engage in consumerism, recreation, and build relationships. Cities use the downtown area to showcase the beauty and appeal of the area to attract new residents or retain current residents. One thing that affects many downtown areas is the presence of visible homelessness. Homelessness is often seen as an unsightly issue that affects local businesses, residents, and tourism. Local governments can choose to push the homeless presence out of downtown or create an environment that helps those in need. This paper …


Bar-Code Variable: A Novel Approach To Efficiently Find Interaction Effects, Lee Sak Park Jan 2024

Bar-Code Variable: A Novel Approach To Efficiently Find Interaction Effects, Lee Sak Park

Theses and Dissertations--Statistics

This paper introduces the bar-code variable, a novel method for processing a sequence of binary explanatory variables efficiently in the linear regression modeling framework. Represented as an integer or a sequence of bits, the bar-code variable captures infor- mation on original binary variables and their potential interaction effects. Utilizing the bar-code variable, the study explores streamlined feature selection in linear re- gression modeling with binary explanatory variables. The paper demonstrates how the bar-code variable, through re-parameterization, facilitates the transition from cell means estimates, µ̂, in the cell-means ANOVA model to coefficient estimates, β̂, in the linear regression model, and vice …


On Generative Models And Joint Architectures For Document-Level Relation Extraction, Aviv Brokman Jan 2024

On Generative Models And Joint Architectures For Document-Level Relation Extraction, Aviv Brokman

Theses and Dissertations--Statistics

Biomedical text is being generated at a high rate in scientific literature publications and electronic health records. Within these documents lies a wealth of potentially useful information in biomedicine. Relation extraction (RE), the process of automating the identification of structured relationships between entities within text, represents a highly sought-after goal in biomedical informatics, offering the potential to unlock deeper insights and connections from this vast corpus of data. In this dissertation, we tackle this problem with a variety of approaches.

We review the recent history of the field of document-level RE. Several themes emerge. First, graph neural networks dominate the …


Current Clinical Concepts: Nonoperative Management Of Shoulder Instability, Margie K. Olds, Timothy L. Uhl Jan 2024

Current Clinical Concepts: Nonoperative Management Of Shoulder Instability, Margie K. Olds, Timothy L. Uhl

Physical Therapy Faculty Publications

Nonoperative management after shoulder dislocation or subluxation remains a challenging and complex task. Accurate diagnosis of the condition and shared decision-making regarding operative and nonoperative management and timing of return to play is required. In this Current Clinical Concepts paper, we introduce a shoulder instability framework that addresses these fundamental clinical dilemmas. Valid clinical prognostic tools that can be used to predict recurrent shoulder instability are reviewed. The process of shared decision-making in the realm of shoulder instability is presented. Finally, a framework for progressive rehabilitation that addresses deficits in motor control, strength, and endurance in scapular and shoulder musculature …


Acute Gastrointestinal Permeability After Traumatic Brain Injury In Mice Precedes A Bloom In Akkermansia Muciniphila Supported By Intestinal Hypoxia, Anthony J. Desana, Steven Estus, Terrence A. Barrett, Kathryn E. Saatman Jan 2024

Acute Gastrointestinal Permeability After Traumatic Brain Injury In Mice Precedes A Bloom In Akkermansia Muciniphila Supported By Intestinal Hypoxia, Anthony J. Desana, Steven Estus, Terrence A. Barrett, Kathryn E. Saatman

Physiology Faculty Publications

Traumatic brain injury (TBI) increases gastrointestinal morbidity and associated mortality. Clinical and preclinical studies implicate gut dysbiosis as a consequence of TBI and an amplifier of brain damage. However, little is known about the association of gut dysbiosis with structural and functional changes of the gastrointestinal tract after an isolated TBI. To assess gastrointestinal dysfunction, mice received a controlled cortical impact or sham brain injury and intestinal permeability was assessed at 4 h, 8 h, 1 d, and 3 d after injury by oral administration of 4 kDa FITC Dextran prior to euthanasia. Quantification of serum fluorescence revealed an acute, …


Receipt Of Follow‑Up Care Plans On Colorectal Cancer Screening Among Breast, Prostate, And Lung Cancer Survivors, Meng-Han Tsai, Malcolm S. Bevel, Sydney E. Andrzejak, Justin X. Moore Jan 2024

Receipt Of Follow‑Up Care Plans On Colorectal Cancer Screening Among Breast, Prostate, And Lung Cancer Survivors, Meng-Han Tsai, Malcolm S. Bevel, Sydney E. Andrzejak, Justin X. Moore

Behavioral Science Faculty Publications

Purpose Our study aimed to examine whether receipt of follow-up care plans is associated with greater guideline-concordant CRC screening stratified by breast, prostate, and lung cancer survivors.

Methods We used data from years 2016, 2018, and 2020 of the Behavioral Risk Factor Surveillance System on 3339 eligible treatment-utilizing cancer survivors with complete treatment. We performed descriptive statistics and multivariable logistic regression to examine the mentioned association.

Results We observed that 83.9% of breast and 88.2% of prostate cancer survivors with follow-care plans received CRC screening (p-value < 0.001). The lowest CRC screening use was observed among lung cancer (70.8%). In multivariable analysis, receipt of follow-up care plans was strongly associated with greater odds of receiving CRC screening in breast (OR, 2.67; 95% CI: 1.71–4.16) and prostate (OR, 3.81; 95% CI: 2.30–6.31) cancer survivors. Regardless of provider type, 84 to 88% reduced likelihood of receipt of CRC screening when they received follow-up care plans among lung cancer survivors. Among those without follow-up care plans, breast (OR, 0.29; 95% CI: 0.09–0.92) and lung (OR, 0.05; 95% CI: 0.01–0.25) cancer survivors who received care from general practices were less likely to receive CRC screening compared to those who received care from non-general practices.

Conclusions Receipt of follow-up care plans was associated with greater CRC screening use in …