Digital Commons Network^™

Contemporary Trends In High-Potency P2y12 Receptor Inhibitor Use Among Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention, Ayman R. Fath, Binish Qureshi, Amro Aglan, Osamah Altaee, Hend Mansoor, Ahmed Almomani, Karim Al-Azizi, Marwan Saad, Andrew M. Goldsweig, Hani Jneid, Islam Y. Elgendy

Pharmacy Practice and Science Faculty Publications

Background: High‐potency P2Y12 receptor inhibitors (ticagrelor and prasugrel) reduce ischemic outcomes compared with clopidogrel among patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). This study aims to examine contemporary trends and identify predictors of their use among patients with AMI undergoing PCI in the United States.   Methods: This observational study used electronic health records from >95 US‐based health care organizations. Adults with AMI who underwent PCI between 2016 and 2023 were included. The primary outcome was the prescription of high‐potency P2Y12 receptor inhibitors versus clopidogrel. Multivariable logistic regression was used to identify independent predictors of P2Y12 inhibitor …

Contraceptive Method Provision Patterns Among Rural And Urban Kentucky Medicaid Enrollees, Dustin K. Miracle, Svetla Slavova, Jeffery Talbert, Daniela C. Moga, Patricia R. Freeman

Pharmacy Practice and Science Faculty Publications

Purpose: To characterize contraceptive provision among the Kentucky Medicaid population and assess for rural−urban disparities.

Methods: Kentucky Medicaid claims from the calendar year 2019 were used to identify females at risk for unintended pregnancy (via a modified version of the criteria defined by the US Department of Health and Human Services Office of Population Affairs). Multinomial logistic regression was used to assess the impact of rural−urban residence on contraceptive outcomes, while adjusting for relevant covariates. Outcomes for the multinomial regression model were provision of a: (1) less effective method (i.e., condoms) or no contraceptive; (2) moderately effective method (oral, transdermal, …

The Dietary Burden Of Phosphorus And Aluminum In Ready-To-Eat Wheat Flour Tortillas Exceeds That Of Corn Tortillas: Implications For Patients With Chronic Kidney Disease, Kate Chander Chiang, Robert Yokel, Jason M. Unrine, Kamyar Kalantar-Zadeh, Ajay Gupta

Pharmaceutical Sciences Faculty Publications

Background: Ready-to-eat, shelf-stable tortillas contain several phosphorus- and aluminum-containing additives that may increase the risk of adverse events in patients with chronic kidney disease (CKD).

Objective: The present study aimed to measure the dietary aluminum and phosphorus burden in store-bought corn and wheat flour tortillas. Design: This cross-sectional study analyzed the elemental content of commercially available corn and wheat flour tortillas collected from 2019 to 2020.

Setting: Twenty-one elements were quantified by ICP-MS and ICP-OES from 14 corn and 13 wheat flour tortilla brands purchased from local supermarkets in Southern California in 2019–2020.

Statistical analyses performed: Multiple group comparisons were …

Altered Bile Acid Transport In Liver Disease, Sarah Cayton, Lindsay C. Czuba

Pharmaceutical Sciences Faculty Publications

Background/Objectives: Bile acids, synthesized from cholesterol in the liver, are amphipathic molecules that play an integral role in lipid digestion and absorption, while also serving as systemic endocrine hormones. They continuously undergo enterohepatic circulation, where they interact with various transporter proteins. Dysregulated bile acid transport is associated with the pathogenesis of liver disease. This review summarizes the key findings relating to bile acid transport expression and activity in the pathogenesis of liver disease.

Methods: A review of the literature was performed using PubMed and relevant terms including, but not limited to, “bile acid transporters”, “liver disease”, and “bile acid uptake …

Chronic Alcohol Consumption Disrupts The Gut Microbial And Metabolic Landscapes, Madison B. Blanton, Ethan G. Napier, Katelyn E. Keen, Ethan V. Stuart, Isaac R. Cinco, Hami Hemati, Ronald C. Bruntz, Landon Wilson, Stephen Barnes, Rupak Khadka, Kathleen A. Grant, Ilhem Messaoudi

Pharmaceutical Sciences Faculty Publications

Introduction: Alcohol use disorder (AUD) increases incidence of infections, organ damage, and cancers. Aberrant inflammation is likely a driver of these adverse outcomes. Indeed, chronic alcohol consumption (CAC) rewires macrophages/monocytes toward a hyper-inflammatory phenotype. Prior studies showed increased gut permeability and dysbiosis. Translocation of host- and microbial-derived metabolites could trigger the hyper-inflammatory responses generated by macrophages/monocytes. However, the exact changes in these metabolites remain poorly defined due to confounders that complicate clinical studies and the differences between human and rodent gut microbiomes.

Methods: Here, we utilized a non-human primate model of ethanol self-administration to characterize alcohol-induced alterations in gut microbes …

Establishing A Public Health Surveillance System For The Opioid Crisis: The Experience Of The Healing Communities Study, Bridget Freisthler, Daniel J. Feaster, Charles Knott, Marc Larochelle, John Mccarthy, Svetla Slavova, Sharon L. Walsh, Jennifer Villani

Biostatistics Faculty Publications

Introduction: Efforts to reduce opioid overdose deaths in the United States have been stymied by the lack of timely and standardized population-level data for local, state, and national levels. The U.S. has a strong national need for linking opioid and other drug overdose surveillance data to service utilization data for overdose prevention and treatment to inform resource allocation and response planning.

Methods: We provide insight on the challenges of identifying, obtaining, and harmonizing administrative outcome data across four states using the collective experience from the HEALing Communities Study to test a community-engaged, data-driven, population-level intervention to reduce opioid overdose deaths. …

Enabling Communication Resiliency In The Connected Car Environment, Antonio Guerrero-Ibáñez, Juan Contreras-Castillo, Sherali Zeadally, Een-Kee Hong

Information Science Faculty Publications

Connectivity has become integral to various application domains, with the automotive sector as a prime example. Advances in electronics, computing, and telecommunications have driven the evolution of the connected car ecosystem, transforming it into a data-rich environment that enhances road safety, efficiency, and overall mobility. However, the success of this ecosystem depends on seamless, reliable, and resilient communications. We identify key challenges that may affect communications in the connected car environment and discuss solutions that enhance resiliency and robustness. Finally, we propose a multi-layered network architecture that will enhance communication resilience in the connected car ecosystem.

Curriculum In Pharmacoepidemiology Training Programs: A Cross-Sectional Study To Assess Educational Needs And Alignment With Core Competencies, Amie Goodin, Deborah Layton, Ryan Chung, Vicki Osborne, Chioma Ejekam, Xiaojuan Li, Xuerong Wen, Kristian B. Filion, Luciane Cruz Lopes, Daniela C. Moga

Pharmacy Practice and Science Faculty Publications

Purpose: Pharmacoepidemiology is a key discipline for evidence-based decision-making, yet its educational programs have not been systematically assessed for alignment with international core competencies. Our objectives were to evaluate curricula alignment of pharmacoepidemiology training programs with ISPE-recommended core competency themes and identify key curriculum content development areas.

Methods: The ISPE Core Competencies Workgroup and ISPE leadership developed a curriculum and needs assessment survey, incorporating feedback from global members. The survey was electronically distributed to leaders of pharmacoepidemiology training programs (e.g., department chairs and program directors) using the ISPE contact database, followed by snowball sampling to enhance representation. Institutional respondent characteristics …

Delivering Safe Sleep And Breastfeeding Education To Pregnant And New Mothers Through Private Facebook Groups: Study Protocol For A 4-Armed Randomized Controlled Trial, Rebecca F. Carlin, Margaret G. Parker, Ann L. Kellams, Fern R. Hauck, Stephen Kerr, Benjamin T. Cornwell, Marc T. Kiviniemi, Nicole Geller, Katherine E. Boguszewski, Michael J. Corwin, Eve R. Colson, Rachel Y. Moon

Health, Behavior & Society Faculty Publications

Background: Annually, more than 3500 US infants die suddenly and unexpectedly. Many sudden unexpected infant deaths (SUID) are preventable with greater adherence to safe infant sleep guidelines. There are racial and economic disparities in guideline adherence and SUID rates. Education alone has proven ineffective at altering behavior for many parents, and social networks and social norms regarding infant care have been found to influence rates of unsafe sleep. Using the power of social networks to shape social norms by delivering education through moderated online social media groups provides a unique opportunity to influence these practices in large groups of parents. …

Feasibility Of Brief Behavioral Telehealth Interventions For Sleep And Pain In Adults With Chronic Musculoskeletal Orofacial Pain: An Idiographic Clinical Trial, Linda Sangalli, Gabriel Gilmore, Isabel Moreno-Hay, Lauren N. Whitehurst, Anna Alessandri-Bonetti, Ian Andres Boggero

Oral Health Science Faculty Publications

Objective: Brief behavioral interventions targeting pain (Physical Self-Regulation, PSR) or sleep (Brief Behavioral Intervention for Insomnia, BBTI) show promise for interdisciplinary management of chronic pain, though their feasibility with chronic musculoskeletal orofacial pain (MSK-OFP) populations remains underexplored. This pilot study assessed the feasibility of a randomized clinical trial (RCT) of these interventions in a university-affiliated tertiary OFP clinic and explored clinical changes in pain, sleep, and other secondary outcomes.

Methods: Treatment-seeking participants (N=19) with chronic MSK-OFP and insomnia were randomized to three-session PSR or BBTI. At pre- and post-intervention, participants completed questionnaires (assessing pain intensity, insomnia symptomatology, sleep …

Expression Pattern Of The Hifα-Family In Equine Chorioallantois During Pregnancy And Placental Pathology, Yatta Boakari, Hossam El-Sheikh Ali, Gustavo Henrique Doná Rodrigues Almeida, Kirsten E. Scoggin, Claudia Barbosa Fernandes, Sophia Panelli Marchio, Mats H. T. Troedsson, Ana Claudia Oliveira Carreira

Maxwell H. Gluck Equine Research Center Faculty Publications

Equine placental dysfunction impairs fetal growth and disrupts pregnancy outcomes. Despite many advances in diagnosis, the molecular pathophysiology of equine placentitis and premature placental separation remains poorly understood. However, the hypoxia-inducible factor (HIF-α) pathway is related to placental hypoxia, and its modulation in placental diseases has been shown in other species. Therefore, we hypothesized that in conditions marked by equine placental dysfunction, oxygen deprivation in the chorioallantois membrane triggers the activation of the HIF-α pathway, which is related to molecular alterations associated with placental insufficiency. Accordingly, we compared the expression of HIF1A, HIF2A, HIF3A, and HIF1AN genes in equine chorioallantois …

Fecal Microbiota Transplantation Modulates Gut Microbiota And Lipid Metabolism To Reduce Diarrhea In Low-Birth-Weight Neonatal Calves, Zhanhe Zhang, Duo You, Donglin Wu, Xintong Li, Yang Jia, David L. Harmon, Ming Xu

Animal and Food Sciences Faculty Publications

This study aimed to elucidate the mechanism by which colonic fecal microbiota transplantation (FMT) improves lipid metabolism in low-birth-weight neonatal calves via modulation of the gut microbial ecosystem. In a completely randomized design, seventy newborn Holstein calves (1 day old, 32.63 ± 3.13 kg BW) were assigned to two groups (35 calves/treatment; 30 females and 5 males per group). A healthy calf was used as a fecal donor. A 10% fecal bacterial suspension was prepared and administered colonically (50 mL, twice daily for 5 days). All calves were fed the same milk replacer and weaned using a step-down protocol at …

Molar–Incisor And Generalized Grade C Periodontitis: Distinct Microbiome–Immune Interactions Suggest Divergent Pathogenesis, Camila S. Stolf, Hélvis E. S. Paz, Murilo C. Paraluppi, Manuela Maria Viana Miguel, Mauro P. Santamaria, Mabelle F. Monteiro, Deyvid E. Amgarten, Raquel R. A. Franco, Luciana S. Branco-De-Almeida, Luciana M. Shaddox, Renato C. V. Casarin

Oral Health Practice Faculty Publications

Aim:

Molar-Incisor (PerioC-MIP) and Generalized (PerioC-G) Grade C Periodontitis could have distinctive etiopathogenesis behind their unique clinical patterns. Thus, this study aimed to distinguish these two phenotypes by analyzing the subgingival metagenomic profile and the inflammatory markers levels.

Methods:

In this cross-sectional comparative study, Gingival Crevicular Fluid (GCF) and Subgingival Biofilm (SB) were collected from 18 PerioC-MIP North Americans and 14 periodontally healthy controls (HC) from the same location (HC-MIP) and 20 PerioC-G Brazilians and 20 controls (HC-G). From GCF, immunoenzymatic analysis was performed. SB functional and taxonomic bacterial content was determined using shotgun metagenomics sequencing.

Results:

Taxonomic results showed …

A Unified Finite Element Framework For Cardiac Growth And Remodeling In Mitral Regurgitation Incorporating Fiber Reorientation And Baroreflex, Mohammad Mehri, Jonathan F. Wenk

Mechanical Engineering Faculty Publications

Mitral regurgitation (MR) triggers complex cardiac remodeling responses that alter the structure and function of the left ventricle (LV). While several models have been developed to predict myocardial growth in MR, they often neglect key concurrent adaptive mechanisms that influence both the pattern and severity of LV dilation. This study presents a unified finite element framework to systematically evaluate the individual and combined contributions of fiber reorientation (FR) and baroreflex regulation to LV growth and remodeling, along with the effects of myocardial material property changes associated with the acute and chronic phases of MR. A healthy baseline model and multiple …

Ev Charging And V2g Operation For Distribution System Vpp Including Model Predictive Control, Rosemary E. Alden, Simone Silvestri, Malcolm D. Mcculloch, Dan M. Ionel

Electrical and Computer Engineering Faculty Publications

Future smart grid virtual power plants (VPPs) are considered for development based on industry communication standards for electric vehicle (EV) chargers such as Open Charge Point Protocol (OCPP), IEC 15118, and IEC 61851. To support research and development of computationally intelligent controls for distributed EV batteries, a python-based API OpenDSS VPP framework is utilized with thousands of experimental smart meter profiles, the IEEE 123 node test feeder, and hundreds of national survey-based EV modules for conventional and optimal charging and vehicle-to-grid (V2G) control development to mitigate any voltage violations and reduce peak load. A methodology is proposed for model-predictive control …

Transcriptional Signatures Of Rapid Protection From Sudan Virus Infection By A Single Dose Of A Vesicular Stomatitis Virus-Based Vaccine, Brianna M. Doratt, Sheridan B. Wagner, Delphine C. Malherbe, Gregory T. Smith, Andrea Marzi, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Sudan virus (SUDV) has caused multiple outbreaks of human disease with case fatality rates ranging from 41 to 100%. We have previously shown that a single vaccination with a recombinant vesicular stomatitis virus-based vaccine expressing the SUDV-Gulu glycoprotein (VSV-SUDV) prevented clinical and fatal disease from lethal SUDV challenge in cynomolgus macaques. With the high probability of future outbreaks, it is critical to determine the molecular mechanisms of VSV-SUDV-mediated protection and the ability to impart rapid protection against SUDV infection. In this study, RNA from whole blood samples obtained from nine cynomolgus macaques that were challenged with SUDV-Gulu post-vaccination with either …

Characterizing Immune Perturbations In Peripheral Blood Following The East Palestine, Ohio Train Derailment, Sheridan B. Wagner, Hami Hemati, Siva Gandhapudi, Timothy J. Hilbert, Candace J. Brancato, Erin N. Haynes, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Background: The East Palestine, Ohio, train derailment on February 3rd, 2023, resulted in the exposure of residents and the surrounding area to numerous hazardous chemicals, which included known acute irritants and human carcinogens. Despite evacuation and cleanup, both residents and responders reported high occurrences of symptoms associated with exposure in the months following, such as eye, skin, and respiratory irritation, headaches, and fatigue. The long-term health consequences for residents remain uncertain.

Objective: To assess the potential for immune perturbations resulting from the exposure, we performed a broad investigation of circulating immune cells and mediators from residents of East Palestine, OH, …

Combinatorial Immunotherapy Drives Exhaustion In Tumor Antigen–Specific Cd8+ T Cells Within The Mouse Renal Tumor Microenvironment, Holly R. Stephens, Elizabeth Elkins, Jing Li, Zoey N. Swalley, Henry Nnaemeka Ogbonna, Pia Muri, Zachary Roberts, Francesca R. Dempsey, Md Akkas Ali, Md Hasanul Banna Siam, Richard Kirkman, Jianqing Zhang, Sunil Sudarshan, Daniel J. Tyrrell, Hubert M. Tse, Daniel L. Smith Jr, Lyse A. Norian

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Immunotherapies have greatly improved outcomes for patients with renal cell carcinoma (RCC), yet response rates remain suboptimal and the factors promoting therapy resistance versus sensitivity are incompletely understood. Currently, no preclinical model of orthotopic renal cancer exists that permits evaluation of tumor antigen–specific (TAS) CD8⁺ tumor-infiltrating lymphocytes (TILs). To address this deficiency, we developed a mouse renal cancer model that permits tracking of adoptively transferred TAS CD8⁺ T cells. Renca-LUC tumor cells were transduced to express tumor ERK (tERK), a model antigen expressing a one-amino-acid change from wild-type ERK, resulting in recognition by tERK/H-2K^d-specific DUC Thy1.1 …

Adolescent Cyberbullying And Polysubstance Use: Unpacking Sex Differences, Maggie K. Richardson, Osayande Agbonlahor, Joy L. Hart, Meman Diaby, Delvon T. Mattingly

Educational, School, and Counseling Psychology Faculty Publications

The rise of social media platforms has heightened cyberbullying among adolescents, closely tied to negative mental health outcomes. Substance use, including alcohol, cannabis, and tobacco, also remains a significant concern for this population. This study examines the relationship between cyberbullying and substance use, exploring potential sex differences in these associations. We analyzed data from the 2021 Adolescent Behaviors and Experiences Survey (ABES) (n = 6,740 students in grades 9–12). We used multinomial logistic regression models to assess the relationship between past-year cyberbullying and current patterns of substance use (exclusive, dual, and poly), adjusting for sociodemographic factors, screen time, and mental …

Legislative Debate-Attributed Suicidality Among Lgbtq+ Adults: The Buffering Effect Of Community Belongingness, Keith J. Watts, Shawndaya S. Thrasher, Laneshia Conner, Nicole Campbell, Louis G. Baser, Dekeitra Griffin, Sydney Howard, Missy Spears, Justin X. Moore

Social Work Faculty Publications

Background: In recent years, the sociopolitical landscape in the United States has shifted due to an increase in state-level legislation regarding LGBTQ+ rights, a trend that has been particularly pronounced in the Commonwealth of Kentucky. While the mental health impacts of enacted laws are increasingly documented, a critical gap remains in understanding the psychological toll of the legislative debates themselves—the prolonged periods of public discourse surrounding the restriction of rights.

Methods: Utilizing data from the 2025 Queer Kentucky Survey (N = 817), this exploratory study examined the association between LGBTQ+ community belongingness and acute suicidality attributed specifically to anti-LGBTQ+ legislative …

The Functional Significance Of Plk1 Phosphorylation Of Nrf2 In Prostate Cancer Progression, Maria Nur

Theses and Dissertations--Toxicology and Cancer Biology

Prostate cancer progression and therapeutic resistance are closely linked to alterations in redox homeostasis and cell cycle regulation. Nuclear factor erythroid 2–related factor 2 (NRF2) is a master regulator of antioxidant responses, yet the mechanisms integrating cell cycle signaling with NRF2 activity in prostate cancer remain poorly defined. In this study, we identify polo‑like kinase 1 (PLK1) as a novel regulator of NRF2 through direct phosphorylation at serine 253 (S253). Using bioinformatic prediction, mass spectrometry, in vitro kinase assays, and cell‑based analyses, we demonstrate that PLK1 phosphorylates NRF2 at S253 in a cell cycle–dependent manner, with maximal phosphorylation during mitosis. …

Assessing Interdisciplinary Learning And Knowledge: A State-Of-The-Art Review And Heuristic, Kacey Beddoes, Kristi Bartlett

Product Design Faculty Publications

Background – The need for interdisciplinary training is increasingly important, but assessing the effects of interdisciplinary education initiatives remains challenging. One of the leading difficulties is identifying and selecting the best instrument or technique for a given purpose.

Purpose -- To help researchers and educators identify available options and determine the best options for their purposes, we conducted a literature review and created a heuristic table of available techniques. Our review addresses the questions: 1) What domain-general techniques and instruments exist for assessing interdisciplinary learning or knowledge? 2) What research scenarios, populations, and questions are each technique or instrument most …

“Oh, You’Ve Come To Visit The Yard?”: Phenotypic Capital, Intragroup Marginalization, And The Gated Sanctuary In Black Lgbtq+ Communities, Keith J. Watts, Shawndaya S. Thrasher, Nicole Campbell, Laneshia Conner, Julian K. Glover, Janet K. Otachi, Dekeitra Griffin

Social Work Faculty Publications

Identity-based communities that share common characteristics, beliefs, and experiences (e.g., Black LGBTQ+ communities) have historically been conceptualized as protective bubbles that buffer Black LGBTQ+ individuals against the deleterious effects of systemic racism and cisheterosexism. However, this monolithic narrative often masks the internal power dynamics that divide belonging. This study explores the exclusionary dynamics embedded within these safe spaces, examining how internal hierarchies of skin tone, socioeconomic status, and gender performance function as proximal stressors. Guided by a critical constructivist paradigm, this study utilized Reflexive Thematic Analysis to analyze open-ended survey responses from 74 Black LGBTQ+ adults. Data were drawn from …

Safety And Efficacy Findings From A Phase Ib/Ii Study Of Asp-1929 Photoimmunotherapy With Pembrolizumab In Recurrent And/Or Metastatic Head And Neck Squamous Cell Carcinoma, David M. Cognetti, Joseph M. Curry, Jennifer Johnson, Michael Kwon, Shirley Y. Su, Francisco Civantos, Coral Olazagasti, Joseph Valentino, Susanne Arnold, R. Bryan Bell, Michael K. Gibson, Kyle Mannion, Kathryn M. Van Abel, Katharine A. Price, Haiying Dong, Amy H. Thorne, Toshiaki Suzuki, Ann M. Gillenwater

Otolaryngology--Head & Neck Surgery Faculty Publications

Background: ASP-1929 photoimmunotherapy—cetuximab conjugated to IRDye 700DX and red light (690 nm) for localized drug activation—results in rapid, selective cell killing.

Methods: This phase Ib/II open-label study evaluated ASP-1929 photoimmunotherapy plus pembrolizumab in patients with recurrent/metastatic HNSCC (≥ 1 accessible lesion, PD-L1 combined positive score ≥ 1, ineligible for standard locoregional ther- apy). Primary objectives were safety/tolerability and objective response rate (ORR). Secondary objectives included overall sur- vival (OS) and progression-free survival (PFS).

Results: Eighteen patients (median age 63 years, 74% male) comprised the photoimmunotherapy-evaluable population. The confirmed ORR was 27.8% (95% CI 9.7–53.5); four of five responders had complete …

Assessment Of Hearing Health Among Adults In Rural Health Clinics, Mit A. Patel, David Adkins, Laura Bellnier, Anthony Mahairas, Matthew L. Bush

Otolaryngology--Head & Neck Surgery Faculty Publications

Objective: Hearing loss (HL) negatively impacts all aspects of health, yet poor access to hearing healthcare (HHC) among adults is a pervasive public health problem. The inaccessibility of HHC is amplified in rural adults. Rural health clinics (RHC) are a critical healthcare system tasked with improving health in rural communities and the objective of this study is to assess the prevalence of HL and the utilization of HHC within RHCs.

Methods: Using cross-sectional study design, adults were recruited from 10 RHC throughout rural Kentucky, mostly within Appalachia. The primary outcomes were (1) presence of HL on screening and (2) history …

German Couples' Mental And Relational Health Before, During, And After Pregnancy: Comparisons Across Conception Type, Mckenna Fey

Theses and Dissertations--Family Sciences

Previous research on the perinatal period (i.e., pregnancy and postpartum) has largely focused on the pregnant partner’s experience and has rarely involved dyadic data from both partners in a romantic relationship. Although mental health—particularly of pregnant partners—has been extensively studied, relational health is often overlooked in the literature. Using life course theory as a framework, the present study examines both pregnant and nonpregnant partners’ mental and relational health before, during, and after pregnancy to understand actor, partner, and cross-process effects. Six hundred and twelve couples (N = 1,224 individuals) from the German Family Panel (pairfam) were assessed for mental and …

Exploring Tonal Focus: Qualitative Perspectives And Acoustic Correlates In Slps And Singers, Lily C. Carpenter

Theses and Dissertations--Communication Sciences and Disorders

Tonal focus is a complex construct that has variable definitions and interpretations across professions and within existing literature. Although tonal focus is widely described both clinically and pedagogically, both fields differ in their perspectives and goals related to the concept. This study aims to understand singers’ and speech language pathologists’ (SLP) conceptual perception and acoustic demonstration of tonal focus. Eleven SLPs and six singers were recruited to participate in the study. Participants completed an interview with the primary investigator and were recorded producing forward, neutral, and backward tonal focus in various contexts. Acoustic and qualitative analysis indicated that tonal focus …

Evaluation And Enhancement Of Suspected Opioid Overdose Definitions In Emergency Medical Services Data Using Machine Learning With Natural Language Processing, Peter Rock, Svetla Slavova, Sharon L. Walsh, Julia Martin, Daniel R. Harris

Institute for Biomedical Informatics Faculty Publications

Background: Fatal and non-fatal drug overdoses have evolved into a critical public health crisis, with over a 50% increase in the rate of fatal drug overdose since 2019. Emergency Medical Services (EMS) data has advantages over traditional emergency department data, including timeliness and captured non-transport encounters. However, there is no consensus EMS definition for suspected opioid overdose (SOO), and currently implemented knowledge-based (KB) definition may miss ambiguous cases. Machine learning with natural language processing (ML-NLP) has the potential to enhance SOO identification.

Methods: Secondary data originated from an oversampled dataset of 2,327 weighted encounters from Kentucky State EMS data (2018–2022). …

Evaluation Of The Healthy Eating And Recovery Together (Heart) Digital Health Intervention To Support Head And Neck Cancer Caregivers And Survivors, Katherine R. Sterba, Jessica L. Burris, Rong Duan, Benjamin A. Toll, Kent Armeson, Christina Sithideth, Bhishamjit Chera, Kenneth Ruggiero, Evan M. Graboyes

Psychology Faculty Publications

Background: Head and neck cancer (HNC) survivors and their caregivers face significant challenges at the end of treatment and interventions are critically needed to support their needs. The Healthy Eating and Recovery Together (HEART) intervention includes a needs assessment and tailored care plan for dyads and an application (App) for caregivers. The objectives of this trial were to evaluate the feasibility, acceptability, and short-term effects of HEART on unmet needs and depression in HNC survivors and caregivers.

Methods: In a single arm clinical trial, HNC caregivers and survivors (n=23 dyads) completed baseline surveys followed by an in-person or virtual HEART …

Exploring Relational Farming Futures For Responsible Innovation In Precision Agriculture Through Q-Method And Speculative Design, Bhavna Joshi, Maaz Gardezi, Edward Prutzer, Awais Hameed Khan, Asim Zia, Benjamin E. K. Ryan, Ali Dadkhah, Donna M. Rizzo, John T. Mcmaine, David Clay

Biosystems and Agricultural Engineering Faculty Publications

This article draws on concepts of speculative design and responsible innovation to examine the possible impacts of data-driven precision agriculture on farmers and farm work. We use an innovative mixed-method approach to research design. Using artistic depiction of futures of precision agriculture in design workshop and in-depth semistructured interviews conducted with the farmers in Vermont and South Dakota, we explain how farmers perceive different futures of precision agriculture. Specifically, in our design workshop, we combined visual arts and social science methods, namely Q-method, to explore existing and new relationships between humans, technologies, and environment in the design, deployment, and use …