Digital Commons Network^™

Estrogen’S Sex-Specific Effects On Ischemic Cell Death And Estrogen Receptor Mrna Expression In Rat Cortical Organotypic Explants, Amanda L. Trout, Christopher J. Mclouth, Jenna Westberry, Tomoko Sengoku, Melinda E. Wilson

Neurology Faculty Publications

Estrogens, such as the biologically active 17-β estradiol (E2), regulate not only reproductive behaviors in adults, but also influence neurodevelopment and neuroprotection in both females and males. E2, contingent upon the timing and concentration of the therapy, is neuroprotective in female and male rodent models of stroke. In Vivo studies suggest that E2 may partially mediate this neuroprotection, particularly in the cortex, via ERα. In Vitro studies, utilizing a chemically induced ischemic injury in cortical explants from both sexes, suggest that ERα or ERβ signaling is needed to mediate the E2 protection. Since we know that the timing and concentration …

Public Justice: Analyzing The Interactions Of Supreme Court Justices With The American Public, Abbie Wood

Theses and Dissertations--Political Science

When and how do Supreme Court justices choose to interact with the public? What motivating factors spur a justice to make a public appearance? In the fields of political science, public law, and legal studies, research has overwhelmingly studied on-the-bench behavior. Scholars have analyzed judicial voting patterns, opinion writing, oral arguments, and more. Despite the prevalence and importance of non-decision making activities as well as the growing reporting by media outlets concerning justices' public appearances, there remains a lack of attention devoted to exploring how justices behave off-the-bench. In this dissertation, I seek to develop this neglected area within judicial …

Adverse Outcomes Of Co-Occurring Methamphetamine And Opioid Use Among Pregnant And Postpartum Women, Hope Tevis

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background

Overdose mortality rates increased significantly between 2018 and 2021 in the United States (NIH, 2023). Moreover, pregnant and postpartum women (PPW), who were aged 35 to 44 were observed to have the highest overdose mortality rates (NIH, 2023). Although there is existing research that examines the increase of co-occurring opioid and methamphetamine use, it still remains understudied when specifically focusing on PPW. This analysis intends to explore this gap in research by 1) exploring the history of co-occurring methamphetamine and opioid use among PPW who were seeking residential treatment, 2) highlighting the adverse health outcomes that follow co-use among …

Evaluating A High School Mrsa Prevention Program: A Case Study, Jamie Henning

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

MRSA poses a significant health risk to athletes nationwide. This case study examines the application of an online training module to address knowledge gaps regarding Methicillin-resistant Staphylococcus aureus (MRSA) among key decision-makers for high school athletes. It reviews the development and initial evaluation of a web-based training program designed to empower decision-makers with the knowledge to prevent MRSA infection and respond to suspected cases. Program evaluation recommended expanding the training module to wrestling staff with improved evaluation methods while continuing implementation and effectiveness assessment for the football staff. Despite initial data quality limitations, the online training module evaluation offered valuable …

A Case Study In Program Evaluation: Evaluation Of A Mrsa Education Program, Kangai Miriti

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Program evaluations provide a deeper understanding of program components to promote effective program implementation. This evaluation follows the CDC’s 6-step Framework for Program Evaluation in Public Health to evaluate a MRSA education program. This evaluation has been prepared to be presented to the Lexington- Fayette County Health Department.

A Case Study In Evaluation, Laura Nagle

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The Lexington – Fayette County Health Department is proposing a comprehensive evaluation of programming focused on preventing MRSA infections among high school athletes within Fayette County Public Schools. This document describes the recommended evaluation process.

A Case Study In Program Evaluation, Kayla Shepherd

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

A program evaluation of a case study presented by the College of Public Health. This case study included a fictitious MRSA outbreak at a Kentucky high school football camp and the response of the Fayette County Public School System (FCPS) and the Lexington-Fayette County Health Department (LFCHD). Using the Centers for Disease Control and Prevention's Framework for Program Evaluation, I evaluated the Educational Infectious Disease Program designed by the FCPS and LFCHD. I provided recommendations to help improve the success of the program.

Team Up Against Overdose Deaths, Mary Elizabeth Pendergrass

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

This grant proposal describes a community collaboration strategy for reducing overdose deaths. Utilizing a Community Advisory Board, the goal of the project is to increase awareness, knowledge, and usage of the Good Samaritan Law to obtain emergency medical care.

A Case Study In Program Evaluation, Sydney Wilcoxson

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Evaluation is a critical component of a successful evidence-based health promotion program or intervention. In public health, evaluations ensure that interventions are achieving their intended objectives, provide feedback on program strengths and weaknesses, and serve as a mechanism of accountability and transparency to stakeholders so that they know their invested resources are being utilized in the most efficient manner. Without evaluation, it would be much more difficult to understand how well the intervention is working, and communication between stakeholders would be significantly affected.

A recently confirmed Methicillin-resistant staphylococcus aureus (MRSA) outbreak on a Fayette County Public Schools (FCPS) high school …

The Relationship Between Self-Reported Depressive Symptoms At 3 Timepoints And Infant Sleep Practices At 6-Month Follow-Up In A Population Of Mothers In Santo Domingo, Ecuador, Kassidy Lane

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Abstract

Background

Previous studies have linked maternal depression with poor infant sleep (e.g., waking up at night and infants having trouble settling to sleep). This study examined the relationship between maternal depressive symptoms at three time points and safe infant sleep at 6-month follow-up.

Methods

Data was collected from a randomized clinical trial including 100 women recruited from a health center in Santo Domingo, Ecuador during their third trimester of pregnancy. Log-binomial regression was used to estimate prevalence ratios (PR) and 95% confidence intervals (CI) of safe infant sleeping at 6 months among mothers who reported depressive symptoms at 3 …

Interprofessional Collaboration In A Lung Cancer Screening Learning Collaborative, Angela Fu

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The primary purpose of this paper is to identify partners and levels of engagement through investigating participants of the Kentucky Lung Cancer Screening Learning Collaborative: Achieving Equity, which was led by the Kentucky Lung Cancer Education Awareness Detection Survivorship (KY LEADS^TM) Prevention and Early Detection team now known as the Quality Implementation of Lung Cancer Screening (QUILS^TM) group in collaboration with the Healthy Kentucky Initiative supported by UK HealthCare. A secondary objective was to identify and categorize organizational and system policies related to lung cancer and screenings. The six-session series focused on equity in lung cancer …

The Relationship Between Social Vulnerability And Cardiovascular Disease Outcomes In Kentucky, Karcyn Brummett

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background: Cardiovascular disease (CVD) is a leading cause of death in the United States, and some regions, such as the Appalachian region, have relatively higher burdens of CVD deaths. CVD has been shown to be influenced by various social factors, with some leading to an increased risk of disease.

Objective: The objectives of this study were to determine the potential correlation between social vulnerability and cardiovascular disease outcomes in Kentucky and how this varies in the Appalachian versus non-Appalachian regions of the state.

Methods: Heart disease death rates and county social vulnerability index (SVI) values in Kentucky were evaluated to …

Adolescent Vaccination Rates And Pharmacists' Ability To Prescribe And Administer, Paul Jake Faulkner

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Vaccines are arguably the most significant advancement in healthcare in the prevention of diseases. The CDC has created a series of recommendations to help guide providers and patients toward a healthier future with vaccines. These recommendations were adopted by the Health People Goals 2020 and 2030 to increase each state's rates of completing specific vaccination series by defined age thresholds. This capstone aims to assess if there is a correlation between vaccination rates and pharmacists; specifically to see if states that give less restrictions about vaccinating would have higher rates. It is also important to see if states with more …

Cardiovascular Disease Among Commercially Insured Adults With Type 1 Diabetes In The Us , 2016-2019, Orighomisan F. Agboghoroma

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objectives: The objective of this study is to examine the overall as well as age- and sex-specific burden of cardiovascular disease (CVD) among adults with type 1 diabetes (T1D) in the US using nationwide commercial claims data from 2016-2019.

Research Design and Methods We used nationwide commercial claims data (1/1/2016-12/31/2019) from Merative™MarketScan to identify adults ≥20 years with T1D (ascertained using ICD-10 codes). CVD was ascertained using ICD-10 diagnostic codes for myocardial infarction, atrial fibrillation, ischemic heart disease, heart failure, peripheral arterial disease, and stroke. The annual prevalence and age-specific prevalence of CVD were calculated. Age-adjusted prevalence of CVD …

Changes In Primary Care Availability In Appalachia, Whitney Beckett

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The Affordable Care Act (ACA) was a groundbreaking moment in the United States healthcare system. It affected many different aspects of the system, including access to primary care professionals. Primary care professionals provide a key role in American’s health, especially when it comes to preventative care. With one-third of Americans experiencing barriers to such access, a solution is desperately needed to increase said access. These barriers are especially profound in low-income, underserved areas such as the Appalachian regions of Georgia, Kentucky, Tennessee, and West Virginia. The ACA attempted to increase access via Medicaid expansion; however, not all States expanded their …

Empirical Insights Into Survivorship Care: A Cross-Sectional Study Of Coc Accredited Hospitals In Kentucky, Amanda M. Beckett

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

ABSTRACT

Background:

Cancer survivorship care programs play a vital role in supporting cancer survivors and improving their quality of life. Understanding the landscape of survivorship and the potential barriers is key to optimizing care delivery.

Methods:

The primary purpose of this cross-sectional study was to explore existing cancer survivorship care programs offered by Commission on Cancer (CoC) accredited hospitals in Kentucky. Data from the Markey Cancer Affiliate Network (MCCAN) from 2022 through 2023 was analyzed. Variables included hospital characteristics such as rural code, types of survivorship services offered, and reported barriers to these services.

Results:

Analysis of n=19 CoC facilities …

Novel Cannabinoid Use Among Young Adults In Lexington, Kentucky, Victoria A. Hamilton

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Purpose: The purpose of this study was to implement a survey to estimate the prevalence of novel cannabinoid use among young adults in Lexington, Kentucky, and to examine modes of use and motivations for novel cannabinoid use. The primary hypothesis of this study was that many respondents would indicate medical reasons for using novel cannabinoids.

Methods: A cross-sectional primary data analysis of 101 young adults in Lexington, Kentucky to determine prevalence of lifetime novel cannabinoid use, past 30-day novel cannabinoid use, mode of use, motivation for use, and related demographic characteristics. Univariate and bivariate analysis were produced using the PROC …

Mccovid Campaign – A Social Media Implementation To Decrease Vaccine Hesitancy In Rural Counties, Harper Ford

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

This capstone will explore the challenges of vaccine hesitancy, a continuously rising problem in the public health field. The focus is primarily on rural millennials in McCracken County, Kentucky. The study identifies key factors contributing to vaccine hesitancy including misinformation, trust issues, and the rapid development of the covid-19 vaccine. To address the above concerns the study proposes a targeted social media campaign using the health belief model to increase COVID-19 vaccine uptake through Facebook ads targeting millennials. The campaigns utilize the leverage of local insights and real-time data to enhance engagement and reduce hesitancy, focusing on adapting strategies based …

Environmental Justice In West Louisville, Ky, Ashley Wright

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

It is evident that West Louisville and Rubbertown are experiencing environmental exposures and related health impacts. It is important for environmental justice (EJ) areas like West Louisville and Rubbertown to gain increased awareness, due to EJ areas commonly being overlooked and forgotten about because of unjust treatment and lack of involvement. Furthermore, all of the data used for this project was publicly accessible. Community residents and the general public can access these data sources to identify which facilities are emitting toxins, as well as specific hazardous substances that are being released, the location of hazardous sites, cleanup status, and more. …

Improving Black Maternal Outcomes In Christian County, Ky: A Social Marketing Approach To Perinatal Provider Change, Ariel A. Arthur

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Compared to other states in the country, Kentucky has historically poor population health outcomes. While the statewide maternal mortality rate is 16.1 per 100,000 live births, this statistic belies the stark racial disparities that exist. In 2018, the pregnancy-related death rate for Black women was 40.2 per 100,000 live births compared to 13.1 for White women. This pattern is persistent even after controlling for socioeconomic status, prenatal care, and other protective factors. Research shows that institutional and interpersonal racism when receiving obstetric care contributes to poor childbirth and postpartum outcomes for Black women. Additionally, geography and rural status may compound …

Implementation Of A Postpartum Depression Program In A Rural Kentucky County, Abby Cecil

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

This paper aims to describe the process of implementing a Postpartum Depression (PPD) prevention program in low-income women residing in rural communities. The paper describes the process of recruiting women in this population, where and how the program will be integrated into an existing clinic, and how the program will be sustained. PPD is a significant global public health problem that can be prevented and treated. The ROSE program (Reach Out, Stay Strong, Essentials for new mothers) is a series of classes that provide informational and social support to prevent PPD. This evidence-based program has been previously successful in reducing …

Increasing Hpv Vaccination In Two Appalachian Counties, Autumn Rice

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

In response to the Funding Opportunity Announcement (FOA), the evidence-based Making Effective HPV Vaccine Recommendations training program will be implemented in the Southeast Kentucky AHEC region over the course of three years. The implementation of the Making Effective HPV Vaccine Recommendations program has three specific aims:

Aim 1: Effectively implement and deliver the Making Effective HPV Vaccine Recommendations program to immunization providers in the Southeast Kentucky AHEC region

Aim 2: Increase provider self-efficacy for making strong recommendations for HPV routinely

Aim 3: Increase the number of recommendations for the HPV vaccine among adolescents of Bell and Harlan Counties in Kentucky …

Patient Access To Glp-1 Ra’S: A Medicare Part D Policy Analysis, Celine Hummer

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

This policy analysis examines the evolving landscape of GLP-1 receptor agonists (GLP-1 RAs) and their implications for Medicare Part D coverage. Initially developed for managing type 2 diabetes, GLP-1 RAs have rapidly gained popularity due to their efficacy in treating obesity and reducing cardiovascular events, leading to broader therapeutic applications. However, access to these medications under Medicare Part D is limited by high costs and coverage restrictions, particularly when used for obesity without diabetes. This analysis evaluates current Medicare Part D policies, including specialty drug tier placement, formulary restrictions, and the potential impact of recent legislative initiatives such as the …

Group Vs. Individual Video Modeling For Acquisition Of Pilates For Individuals With Disabilities, Brittany Rounce

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

This study presents findings from an alternating treatment design investigation into the efficacy of group versus individual video modeling in facilitating the acquisition of Pilates techniques among individuals with disabilities. The study aimed to assess how these different instructional modalities influenced participants' learning outcomes. The research involved a detailed analysis of two participants, with a focus on observing any variations in their response patterns during the acquisition phase. Through systematic data collection and analysis, the study evaluated the effectiveness of group versus individual Pilates video modeling. The results revealed distinct responses within the participant group, with one individual exhibiting differential …

Training Paraprofessionals In The Implementation Of Aided Language Modeling With Individuals With Intellectual Disabilities And Ccn, Julianne Hill

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

The purpose of this research is to train special education paraprofessionals in the implementation of Aided Language Modeling (ALM) through a coaching program. A single-case multiple probe design across three paraprofessional/student dyads was used to analyze data. Coaching procedures included a single 20-minute training workshop with the researcher between baseline and intervention and post-session conversations after each intervention trial. The research took place in a public school in the southeastern United States. The school was located outside of a metropolitan area in a suburban school district. The study took place to answer the following questions: (1) With the implementation of …

Comparison Of Video Modeling And In-Vivo Language Instruction In Preschool, Jessah Marlee Hughes

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Early communication and language development in young children is critically important and those identified as having a language delay, would benefit from intervention. There is a rise in screen time exposure in young children, with some watching variations of popular evidence-based practices (time delay, video modeling, etc.) Most notably, Ms. Rachel is an early childhood learning YouTube sensation. This study seeks to compare the effectiveness and efficiency of video modeling and time delay in the differential use of early sentences during play-based activities.

Supporting Children’S Eating Behavior In A Preschool Classroom, Olajumoke Leshi

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Food selectivity, commonly observed in young children, has a significant effect on their health outcomes, and this poses a major challenge for parents and caregivers. This proposed study aims to investigate the effectiveness of a teaching package comprising prompting, shaping, and reinforcement strategies in enhancing exploratory eating behaviors among preschool children displaying food selectivity in a classroom setting. The study seeks to answer the research question: does the delivery of a teaching package consisting of prompting, shaping, and reinforcement result in an increase in exploratory eating behaviors (touch, smell, taste) by young children displaying food selectivity? This study will use …

Differential Effects Of Criteria For Increasing Delay Intervals In Progressive Time Delay, Kai O'Neill

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

The purpose of the study was to compare the differential effects of response independent and response-dependent criteria used to determine when to increase to the next delay interval in the progressive time delay (PTD) procedure. An adapted alternating treatments design was used to evaluate the relative efficiency of three variations of the PTD procedure when teaching expressive word identification to first-grade children with moderate to severe intellectual or developmental disabilities, language impairments, and reading deficits. All three PTD variations consisted of increasing the delay interval in 1-s increments from 0s to 4s. The three PTD variations compared included (a) a …

Trauma And Parenting: Are There Unintentional Effects?, A'Tora Hill

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

The goal in conducting this study was to explore the effects of trauma across generations, if any were to be confirmed. This study, specifically, aimed to investigate whether parents reported having dealt with trauma and if their trauma had any impact on the way they parent their children. Research has shown that parents who have endured trauma take on different parenting styles and techniques than those who have not endured trauma. This study highlights the effects of trauma on those who encounter it as well as how it may transcend through generations through a survey. A key outcome of this …

The Effects Of Hierarchical Training On The Emergence Of Emotion-Related Metaphors In Autistic Children, Katherine Lynch

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Recently, research on derived relational responding has increased in volume, along with the publication of assessments, curricula, and textbooks on this topic. The allure of engineering derived relations due to purported accelerated learning makes this topic interesting to researchers and practitioners. Recent reviews have examined types of verbal operants, and specific relational frames studied in this body of literature, but there is scarcity in terms of the instructional procedures and variations thereof, and there is little available to focus on single case design (SCD) evaluations of these procedures. Hierarchical training (HT) to produce derived relations between arbitrary stimuli has shown …