Digital Commons Network^™

Implantable Controlled Release Device To Deliver Drugs Directly To An Internal Portion Of The Body, Paul Ashton, Paul A. Pearson

Ophthalmology and Visual Science Faculty Patents

A simple and implantable sustained release drug delivery device with an inner core containing an effective amount of a low solubility agent covered by a non-bioerodible polymer coating layer that is permeable to the low solubility agent is disclosed. A method for treating a mammal to obtain a desired local or systemic physiological or pharmacological effect by surgically implanting such a sustained release drug delivery device into a mammal in need of treatment is also disclosed.

The Snare Machinery Is Involved In Apical Plasma Membrane Trafficking In Mdck Cells, Seng Hui Low, Steven J. Chapin, Christian Wimmer, Sidney W. Whiteheart, László G. Kömüves, Keith E. Mostov, Thomas Weimbs

Molecular and Cellular Biochemistry Faculty Publications

We have investigated the controversial involvement of components of the SNARE (soluble N-ethyl maleimide–sensitive factor [NSF] attachment protein [SNAP] receptor) machinery in membrane traffic to the apical plasma membrane of polarized epithelial (MDCK) cells. Overexpression of syntaxin 3, but not of syntaxins 2 or 4, caused an inhibition of TGN to apical transport and apical recycling, and leads to an accumulation of small vesicles underneath the apical plasma membrane. All other tested transport steps were unaffected by syntaxin 3 overexpression. Botulinum neurotoxin E, which cleaves SNAP-23, and antibodies against α-SNAP inhibit both TGN to apical and basolateral transport in …

Method Of Discrete Orthogonal Basis Restoration, Edward B. Moody

Radiology Faculty Patents

A method is described for utilizing discrete orthogonal basis to restore signal system, such as radio or sound waves and/or image system such as photographs or medical images that become distorted while being acquired, transmitted and/or received. The signal or image systems are of the linear type and may be represented by the equation [B] [o]= [i] wherein [o] is an original signal or image, [i] is a degraded signal or image and [B] is a system transfer function matrix. The method involves estimating a signal-to-noise ratio for a restored signal or image. Next, is the selecting of a set …

Farmer Run Over By Tractor, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

An 80-year-old male farmer (the victim) died when he was run over by the right rear wheel of his tractor. He had backed the tractor to the door of a shed in order to hook a tiller to it. After parking the tractor on a slight incline in front of the shed, he left it in neutral while he went inside for the tiller. The parking brake did not hold, however, and the tractor began to roll. He apparently noticed this and tried to remount the tractor, but was knocked down by the wheel and run over. To prevent similar …

N-Chloro-N-Methyl Glucamine And N-Chloro-N-Methyl Glucamine Esters As Novel Safe Agents For Water Disinfetion, Anwar A. Hussain, Bassam Tashtoush, Lewis W. Dittert

Pharmaceutical Sciences Faculty Patents

The present invention relates to N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters, and their use as agents for water disinfection and as mild oxidizing agents for the radiolabeling of oxidation-sensitive biomolecules.

Angled Snare Assembly, Bradley B. Hill

Surgery Faculty Patents

A snare assembly includes an outer, flexible sheath having a distal opening and a loop received for relative sliding movement with respect to the sheath. The loop has a proximal end and a distal end. The loop is formed from a resilient wire and includes a substantially 180° reverse bend at a midpoint forming the distal end and the ends of the wire are fastened together at the proximal end. A control handle is carried on the sheath for extending and retracting the loop out of and into the sheath through the distal opening. A flexible connector connects the control …

College Of Law Commencement Program, 1998, University Of Kentucky

Graduation Programs

No abstract provided.

The Enforcement Of Prisoners’ Rights In The United States: An Access To The Courts Issue, Roberta M. Harding

Law Faculty Scholarly Articles

This article examines how the development and status of the rights of incarcerated people is significantly effected by their ability to access the judiciary; specifically the federal judicial system. The relatively recent explosion in the American prison population provided the impetus for researching this topic. The objective was to examine whether this tremendous rise in the number of people incarcerated in U.S. penal facilities had impacted the posture of the rights afforded to these individuals. One conclusion reached was that the rise in the prison population had harshly eroded the right of access to the courts. The exploration of the …

(Re) Presenting Power. Disclosure Interviews Jane Flax, Susan Mains, Meredith Redlin

disClosure: A Journal of Social Theory

No abstract provided.

Electrician Dies In 6-Foot Fall From Ladder, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Falls

A 51-year-old male electrician (the victim) died after falling approximately six feet to the concrete floor of a fertilizer plant. The victim had been doing electrical work while standing on an aluminum extension ladder at a switch box attached to a steel post near a rear exit of the plant. His co-worker, who was approximately 20 feet away, heard him hit the floor, but did not see him fall. The co-worker ran for help. A 911 call was placed at 8:46 am, and Emergency Medical Services (EMS) personnel arrived in three minutes. The victim was transported to the local hospital, …

Privatization Of Social Security: Misguided Reform, Kathryn L. Moore

Law Faculty Scholarly Articles

This article begins by briefly describing the social security program. It then discusses the reasons for social security's widespread popularity and its impending funding crisis. The article goes on to briefly describe some of the pending privatization proposals. The article concludes by discussing the practical and theoretical problems with privatizing social security. Specifically, it describes the investment risk participants face under a privatized system and the transition problems created by converting to such a system. Finally, this article explains why the privatization proposals promote misguided paternalism and misconceive the role social security should play in our national retirement system.

A Report On County Road Program Finance, Patsy Anderson, Kris Koehler

Kentucky Transportation Center Research Report

This report reflects the findings of a study of county road finance in Kentucky. Statistics contained in the report were derived from financial statements submitted by the counties to the Kentucky Department of Local Government.

Cyberlaundering: The Risks, The Responses, Sarah N. Welling, Andy G. Rickman

Law Faculty Scholarly Articles

This Article discusses the potential use of electronic cash for money laundering and possible government responses to the problem. Parts I and II provide an overview of electronic cash. Part III explores the effects that electronic cash can have on money laundering. Part IV explains through a series of hypotheticals how "cyberlaundering" can occur. Part V analyzes the federal government's response to the threat of money laundering with electronic cash. Part VI concludes the Article with suggestions.

Managing Spring Dead Spot Of Bermudagrass, Paul C. Vincelli, David Williams

Agriculture and Natural Resources Publications

Spring dead spot is the most destructive disease of bermudagrass in Kentucky. The most serious outbreaks occur under high maintenance conditions; e.g., high nitrogen fertility, low mowing height, and frequent traffic. Moderate to severe outbreaks can occur under low-maintenance conditions as well.

High levels of resistance to spring dead spot in bermudagrass varieties have not yet been demonstrated experimentally. Limited data suggest that those varieties with best winter hardiness are somewhat less susceptible to the disease. To date, no confirmed cases of spring dead spot have been documented in “Quickstand” bermudagrass, which may indicate that this variety will suffer less …

Forage News [1998-02], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• National Alfalfa Symposium and XVIII Kentucky Alfalfa Conference February 26-27, 1998 University Plaza Hotel & Convention Center Bowling Green, Kentucky
• KFGC Awards to be Presented at Alfalfa Symposium
• U.K. All Commodity Field Day
• Grazing School for Spring 1998
• More Forage Learning Opportunities
• Forage Variety Reports
• Poultry Litter for Pastures
• Influence of Seedling Growth on Flooding Injury in Alfalfa
• Upcoming Events

Method For Reducing The Generation Of Wear Particulates From An Implant, David A. Pienkowski, Kwon-Yong Lee

Biomedical Engineering Faculty Patents

A method is provided for reducing the amount of wear particulates generated by a total joint orthopaedic implant. The implant consists of two matched articulating components wherein at least one of the components is made of polymer or other material with similar physical properties. The method includes the steps of placing the total joint orthopaedic implant in a fluid bath and articulating the implant in the fluid bath for at least 1,000 cycles. The articulation may be performed in three stages. In the first, the implant is articulated under a load of substantially 0.1-500 Newtons with sliding speeds of substantially …

The Reemergence Of The Sovereign Immunity Doctrine In Kentucky, Earl F. Hamm Jr.

Kentucky Law Journal

No abstract provided.

Experiencing Physical Violence During Pregnancy: Prevalence And Correlates, Vilma E. Cokkinides, Ann L. Coker

CRVAW Faculty Journal Articles

Violence during pregnancy directly impacts the mental and physical health of pregnant women. We assessed the prevalence and correlates of physical violence around the time of pregnancy in a representative sample of 6,718 women in South Carolina. Physical violence, defined as "being physically hurt by husband or partner" or "being involved in a physical fight" was reported by 10.9% of recently pregnant women. These were correlates of violence: experiencing increased numbers of stressful life events, being unmarried, having increased parity, being on Medicaid, and having an unwanted pregnancy. Screening to identify violence in pregnancy in health care settings is vital …

Violence Against Women In Sierra Leone: Frequency And Correlates Of Intimate Partner Violence And Forced Sexual Intercourse, Ann L. Coker, Donna L. Richter

CRVAW Faculty Journal Articles

Violence against women is a significant public health problem which impacts women, men, and children. Little is known about the frequency or correlates of violence against women in Africa. In this cross-sectional study, we found that 66.7% of 144 women surveyed in a study of AIDS knowledge, attitude, and behaviours, report being beaten by an intimate male partner and 50.7% report having ever been forced to have sexual intercourse; 76.6% of women report either forced sex or intimate partner violence. Circumcised women were most likely to report intimate partner violence and forced sexual intercourse. To improve the health of women …

Chain Saw Hazard Alert, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Tractors/Logging

A review of 74 cases of chain saw injuries to Kentucky farmers revealed that most occurred while the farmers were clearing fence lines. Most of the injuries occurred in the spring, from March through April, and in the fall, from October through November. As for time of day, most happened in the morning, from 8:30 to 10, and in the early afternoon, from 12 to 3.

Described below are two representative incidents, followed by recommendations for prevention of similar injuries.

Water Systems For Controlled Grazing, Larry W. Turner

Agricultural Engineering Extension Updates

Intensive controlled or rotational grazing can be an important tool for beef and dairy producers in Kentucky. A key component for success with this type of operation is the availability of adequate drinking water for livestock on pasture.

Quantities, flow rates and location of water for rotational grazing will be considered in this fact sheet. Systems supplying water under pressure through hose or pipe to a tank or water bowl will be discussed in detail.

Kentucky Annual Economic Report 1998, Mark C. Berger, Glenn C. Blomquist, Richard W. Furst, Steven N. Allen

Kentucky Annual Economic Report

No abstract provided.

Lack Of Effect Of Leptin On Glucose Transport, Lipoprotein Lipase, And Insulin Action In Adipose And Muscle Cells, Subramanian Ranganathan, Theodore P. Ciaraldi, Robert R. Henry, Sunder Mudaliar, Philip A. Kern

Clinical and Translational Science Faculty Publications

The effect of leptin on glucose transport, lipogenesis, and lipoprotein lipase activity was studied in cultured rat adipocytes and 3T3-L1 adipocytes. Leptin had no effect on basal and insulin stimulated glucose transport in isolated adipocytes from the rat and the genetically obese mouse. The incorporation of glucose into lipids was also unaffected. Lipoprotein lipase (LPL) activity remained unchanged in response to leptin in these cells, as well as in minced adipose tissue. Leptin also had no effect on both basal and insulin-stimulated glucose transport in cultured rat and human skeletal muscle cells. These studies showed that leptin had no effect …

Effects Of Tumor Necrosis Factor-Α On Glucose Metabolism In Cultured Human Muscle Cells From Nondiabetic And Type 2 Diabetic Subjects, Theodore P. Ciaraldi, Leslie Carter, Sunder Mudaliar, Philip A. Kern, Robert R. Henry

Clinical and Translational Science Faculty Publications

The effects of tumor necrosis factor-a (TNFα) on glucose uptake and glycogen synthase (GS) activity were studied in human skeletal muscle cell cultures from nondiabetic and type 2 diabetic subjects. In nondiabetic muscle cells, acute (90-Min) exposure to TNFα (5 ng/ml) stimulated glucose uptake (73 ± 14% increase) to a greater extent than insulin (37 ± 4%; P < 0.02). The acute uptake response to TNFα in diabetic cells (51 ± 6% increase) was also greater than that to insulin (31 ± 3%; P < 0.05). Prolonged (24-h) exposure of nondiabetic muscle cells to TNFα resulted in a further stimulation of uptake (152 ± 31%; P < 0.05), whereas the increase in cells from type 2 diabetics was not significant compared with that in cells receiving acute treatment. After TNFα treatment, the level of glucose transporter-1 protein was elevated in nondiabetic (4.6-fold increase) and type 2 (1.7-fold) cells. Acute TNFα treatment had no effect on the fractional velocity of GS in either nondiabetic or type 2 cells. Prolonged exposure reduced the GS fractional velocity in both nondiabetic and diabetic cells. In summary, both acute and prolonged treatment with TNFα up-regulate glucose uptake activity in cultured human muscle cells, but reduce GS activity. Increased skeletal muscle glucose uptake in conditions of TNFα excess may serve as a compensatory mechanism in the insulin resistance of type 2 diabetes.

Absence Of Detectable Pharmacological Effects After Oral Administration Of Isoxsuprine, J. Daniel Harkins, G. D. Mundy, S. Stanley, W. E. Woods, R. A. Sams, D. R. Richardson, S. C. Grambow, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Isoxsuprine is reported to be a peripheral vasodilator used in human and veterinary medicine to treat ischaemic vascular disease. In horses, it is generally administered orally to treat navicular disease and other lower limb problems. To deflne the scope and duration of its pharmacological responses after oral administration, 6 horses were dosed with isoxsuprine HCI (1.2 mg/kg bwt) q. 12 h for 8 days and then tested to assess the duration and extent of pharmacological actions. There was no significant difference between isoxsuprine and control treatment values for heart rate, spontaneous activity, sweat production, anal muscle tone, core and skin …

An Overview Of The Methylxanthines And Their Regulation In The Horse, J Daniel Harkins, W. Allen Rees, G. D. Mundy, Scott D. Stanley, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Caffiene, theophylline and theobromine are naturally occurring members of the methylxanthine family;pentoxfylline, dyphylline and enprofylline are structurally related synthetic pharmaceuticals. Caffiene has predominantly central nervous system effects, theophylline, dyphylline and enprofylline have predominantly bronchodilator effects, while theobromine is associated with diuretic responses. Pentoxfylline is thought to increase red cell deformability and facillitate blood flow through capillary beds. The methylxanthines are not highly potent agents; they are typically administered in gram doses and they tend to have relatively long half-lives. They remain detectable in plasma and urine for relatively long periods. Similarly, traces of the naturally occurring members of this family …

Kentucky Lawyer, 1998-1999, University Of Kentucky College Of Law

Annual Magazines

No abstract provided.

Summary Adjudication In United States Civil Procedure, Mary J. Davis

Law Faculty Scholarly Articles

This article uses one of the high profile mass tort cases of recent decades, the complex silicone gel-filled breast implant products liability litigation, to evaluate summary adjudication measures. Recognizing that not all claims filed are complex tort claims (just the most interesting ones), where commercial claims present the opportunity for use of summary proceedings, those will be discussed as well, particularly regarding mechanisms by which security for a creditor-plaintiffs claim can be obtained prior to a favorable verdict.

While preparing this Report, it became clear that the author has a particular view of what constitutes a "summary adjudication" procedure, but …

Three Generations Of Welfare Mothers Are Enough: A Disturbing Return To Eugenics In The Recent "Workfare" Law, Nicole Huberfeld

Law Faculty Scholarly Articles

In this Article, Nicole Huberfeld examines recent changes in the welfare system, and considers whether these changes are consistent with the stated goals of the Personal Responsibility and Work Opportunity Reconciliation Act of 1996. Turning to the history of “workfare,” Huberfeld reveals parallels between the reasoning of its proponents, and that of eugenicists. She argues that workfare mirrors eugenics theory because its proponents are imposing particular white, middleclass values upon the poor as a condition to providing them benefits: Through her comparison of workfare and eugenics, Huberfeld cautions against legislation that seeks to regulate the private conduct and personal decisions …

Reframing The Affirmative Action Debate, Lani Guinier

Kentucky Law Journal

No abstract provided.