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Table F: Daily Dietary Aluminum Consumption, Robert Yokel Nov 2024

Table F: Daily Dietary Aluminum Consumption, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Table A: Temperature Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel Nov 2024

Table A: Temperature Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Improving Transportation Resiliency, Ben Blandford, Erin Lammers-Staats, Emma Gregory Nov 2024

Improving Transportation Resiliency, Ben Blandford, Erin Lammers-Staats, Emma Gregory

Kentucky Transportation Center Research Report

Transportation agencies are increasingly more challenged by the effects of extreme weather and national hazards on transportation assets.  Severe weather events in Kentucky have become more frequent and more costly. These extreme events damage transportation assets, increase maintenance costs and strain transportation budgets. Climate models predict changing conditions to occur over the next century that differ from historical data. In Kentucky, models predict a warmer and wetter environment. The goal of this research is to help KYTC plan for extreme weather and natural hazards events, as well as absorb, recover from, and adapt to the resulting damage.  Researchers determined where …


Tap Vs. Bottled Water, Robert Yokel Nov 2024

Tap Vs. Bottled Water, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Chamomile Infusion, Robert Yokel Nov 2024

Chamomile Infusion, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Oolong Tea Infusion, Robert Yokel Nov 2024

Oolong Tea Infusion, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Puer Tea, Dry, Robert Yokel Nov 2024

Puer Tea, Dry, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Yogurt, Robert Yokel Nov 2024

Yogurt, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Cephalopods (Cuttlefish, Octopus, And Squid), Robert Yokel Nov 2024

Cephalopods (Cuttlefish, Octopus, And Squid), Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Vinegar, Robert Yokel Nov 2024

Vinegar, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Grapefruit And Grapefruit Juice, Robert Yokel Nov 2024

Grapefruit And Grapefruit Juice, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Grape Juice, Robert Yokel Nov 2024

Grape Juice, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Table F: Fluoride Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel Nov 2024

Table F: Fluoride Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Coffee Beverage, Robert Yokel Nov 2024

Coffee Beverage, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Beyond 2d: Novel Biomaterial Approaches For Modeling The Placenta, Samantha G. Zambuto, Adrienne K. Scott, Michelle L. Oyen Nov 2024

Beyond 2d: Novel Biomaterial Approaches For Modeling The Placenta, Samantha G. Zambuto, Adrienne K. Scott, Michelle L. Oyen

Biomedical Engineering Faculty Publications

This review considers fully three-dimensional biomaterial environments of varying complexity as these pertain to research on the placenta. The developments in placental cell sources are first considered, along with the corresponding maternal cells with which the trophoblast interact. We consider biomaterial sources, including hybrid and composite biomaterials. Properties and characterization of biomaterials are discussed in the context of material design for specific placental applications. The development of increasingly complicated three-dimensional structures includes examples of advanced fabrication methods such as microfluidic device fabri- cation and 3D bioprinting, as utilized in a placenta context. The review finishes with a discussion of the …


Frequency Of Low Impact Scores Among Adolescent And Young Adult Student-Athletes With Attention-Deficit/Hyperactivity Disorder And/Or Learning Disorder, Philip Schatz, John Cuzzupe, Justin E. Karr, Nathan E. Cook, Grant L. Iverson Nov 2024

Frequency Of Low Impact Scores Among Adolescent And Young Adult Student-Athletes With Attention-Deficit/Hyperactivity Disorder And/Or Learning Disorder, Philip Schatz, John Cuzzupe, Justin E. Karr, Nathan E. Cook, Grant L. Iverson

Neurology Faculty Publications

Introduction: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by attention problems, excessive activity, and impulsivity - occurring in approximately 13% of children 12– 17 years of age, and as many as 16% of older adolescents 18–22 years of age, with a greater prevalence in boys than girls. ADHD frequently co-occurs with specific learning disorder (LD), a neurodevelopmental disorder characterized by difficulties learning and using academic skills, such as reading, writing, and mathematics. Taken together, ADHD and/or LD are common among high school students and college students and can influence performance on computerized tests used in concussion management. However, normative …


The Role Of A Dental Healthcare Provider, Jeffrey P. Okeson Nov 2024

The Role Of A Dental Healthcare Provider, Jeffrey P. Okeson

Neurology Faculty Publications

No abstract provided.


Novel Multi-Omics Deconfounding Variational Autoencoders Can Obtain Meaningful Disease Subtyping, Zuqi Li, Sonja Katz, Edoardo Saccenti, David W. Fardo, Peter Claes, Vitor A.P. Martins Dos Santos, Kristel Van Steen, Gennady V. Roshchupkin Nov 2024

Novel Multi-Omics Deconfounding Variational Autoencoders Can Obtain Meaningful Disease Subtyping, Zuqi Li, Sonja Katz, Edoardo Saccenti, David W. Fardo, Peter Claes, Vitor A.P. Martins Dos Santos, Kristel Van Steen, Gennady V. Roshchupkin

Biostatistics Faculty Publications

Unsupervised learning, particularly clustering, plays a pivotal role in disease subtyping and patient stratification, especially with the abundance of large-scale multi-omics data. Deep learning models, such as variational autoencoders (VAEs), can enhance clustering algorithms by leveraging inter-individual heterogeneity. However, the impact of confounders—external factors unrelated to the condition, e.g. batch effect or age—on clustering is often overlooked, introducing bias and spurious biological conclusions. In this work, we introduce four novel VAE-based deconfounding frameworks tailored for clustering multi-omics data. These frameworks effectively mitigate confounding effects while preserving genuine biological patterns. The deconfounding strategies employed include (i) removal of latent features correlated …


Seasonal Variation In Atp-Induced Retinal Damage In The Cone-Dominant 13-Lined Ground Squirrel, Owen R. Bowie, Hannahm Follett, Ching Tzu Yu, Chloe Guillaume, Phyllis M. Summerfelt, Nicole Manfredonia, Jenna Grieshop, Dana K. Merriman, Sergey Tarima, Joseph Carroll Nov 2024

Seasonal Variation In Atp-Induced Retinal Damage In The Cone-Dominant 13-Lined Ground Squirrel, Owen R. Bowie, Hannahm Follett, Ching Tzu Yu, Chloe Guillaume, Phyllis M. Summerfelt, Nicole Manfredonia, Jenna Grieshop, Dana K. Merriman, Sergey Tarima, Joseph Carroll

Biostatistics Faculty Publications

Purpose: To examine whether time of year (relative to hibernation emergence) influences the retinal degenerative effects of intravitreal injection of adenosine triphosphate (ATP) in the 13-lined ground squirrel (13-LGS). Methods: Eighteen (9 male, 9 female) 13-LGS in three experimental cohorts (early season, mid-season, late season) (n = 6 each) underwent baseline imaging using scanning light ophthalmoscopy (SLO) and optical coherence tomography (OCT). Animals then received a 10-μL intravitreal injection of 0.723 M ATP, followed by OCT and SLO imaging at 3, 10, and 21 days. Adaptive optics SLO (AOSLO) was performed in animals without retinal damage after the 21-day follow-up. …


A Method For Teaching Biostatisticians To Write And Critique Specific Aims, Jesse D. Troy, Gregory P. Samsa, Megan L. Neely, Steven C. Grambow, Sarah Peskoe, Emily Slade, Gina Maria Pomann Nov 2024

A Method For Teaching Biostatisticians To Write And Critique Specific Aims, Jesse D. Troy, Gregory P. Samsa, Megan L. Neely, Steven C. Grambow, Sarah Peskoe, Emily Slade, Gina Maria Pomann

Biostatistics Faculty Publications

This article describes the design of a single instructional module on writing and critiquing the Specific Aims (SA) section of a grant proposal for a biomedical research study. It begins by discussing the goals and learning objectives for the module. Then, it discusses the typical structure of a SA section to orient readers to the core content. This method is rooted in using an established framework for scientific writing, which is presented in brief, along with examples of how it applies to writing the SA section. Then, the structure of the instructional module is described, including the exercises for participants. …


Clonidine As Monotherapy For Neonatal Opioid Withdrawal Syndrome, Henrietta S. Bada, Philip M. Westgate, Thitinart Sithisarn, Kimberly Yolton, Richard Charnigo, Massroor Pourcyrous, Fei Tang, Julia Gibson, Jennifer Shearer-Miller, Peter Giannone, Markos Leggas Nov 2024

Clonidine As Monotherapy For Neonatal Opioid Withdrawal Syndrome, Henrietta S. Bada, Philip M. Westgate, Thitinart Sithisarn, Kimberly Yolton, Richard Charnigo, Massroor Pourcyrous, Fei Tang, Julia Gibson, Jennifer Shearer-Miller, Peter Giannone, Markos Leggas

Biostatistics Faculty Publications

OBJECTIVE: We sought to determine whether clonidine, a non-opioid a―2-adrenergic agonist, would effectively treat neonatal opioid withdrawal syndrome (NOWS). METHODS: This was an intention-to-treat randomized clinical trial. Enrollment criteria included prenatal opioid exposure, age #7 days, gestational age $35 weeks, no other medical condition, and need for pharmacotherapy. Primary outcomes were length of treatment and neurobehavioral performance. RESULTS: A total of 1107 patients were screened for enrollment (645 ineligible, 91 parents or staff unavailable, 216 declined, 155 consented). Of 155 infants, 120 required treatment and were randomized to receive oral clonidine (n 5 60) at 1 mg/kg/dose or morphine (n …


Repeated Shifts In Sociality Are Associated With Fine-Tuning Of Highly Conserved And Lineage-Specific Enhancers In A Socially Flexible Bee, Beryl M. Jones, Andrew E. Webb, Scott M. Geib, Sheina Sim, Rena M. Schweizer, Michael G. Branstetter, Jay D. Evans, Sarah D. Kocher Nov 2024

Repeated Shifts In Sociality Are Associated With Fine-Tuning Of Highly Conserved And Lineage-Specific Enhancers In A Socially Flexible Bee, Beryl M. Jones, Andrew E. Webb, Scott M. Geib, Sheina Sim, Rena M. Schweizer, Michael G. Branstetter, Jay D. Evans, Sarah D. Kocher

Entomology Faculty Publications

Comparative genomic studies of social insects suggest that changes in gene regulation are associated with evolutionary transitions in social behavior, but the activity of predicted regulatory regions has not been tested empirically. We used self-transcribing active regulatory region sequencing, a high-throughput enhancer discovery tool, to identify and measure the activity of enhancers in the socially variable sweat bee, Lasioglossum albipes. We identified over 36,000 enhancers in the L. albipes genome from 3 social and 3 solitary populations. Many enhancers were identified in only a subset of L. albipes populations, revealing rapid divergence in regulatory regions within this species. Population-specific enhancers …


Adverse Childhood Experiences And Psychological Correlates Of Substance Use Disorders Among Black Sexual Minority Women, Shemeka Thorpe, Kaylee A Palomino, Natalie Malone, Danelle Stevens-Watkins Nov 2024

Adverse Childhood Experiences And Psychological Correlates Of Substance Use Disorders Among Black Sexual Minority Women, Shemeka Thorpe, Kaylee A Palomino, Natalie Malone, Danelle Stevens-Watkins

Kinesiology and Health Promotion Faculty Publications

This study examined the influence of adverse childhood experiences (ACEs) on Black sexual minority women's mental health and substance use disorders in adulthood. Secondary data analysis was conducted using N = 149 Black sexual minority women's reports from the Generations Study. Study variables included psychological distress, chronic strains, stressful life events, ACEs, and substance use disorders, including alcohol use disorder and drug use disorder. Quantitative data analysis consisted of descriptives and bivariate correlations. Participants' total ACE scores were positively significantly correlated with increased alcohol misuse, chronic life strains, and stressful life events. Exposure to household interpersonal violence and household mental …


Engineering The Coherent Phonon Transport In Polar Ferromagnetic Oxide Superlattices, In Hyeok Choi, Seung Gyo Jeong, Do-Gyeom Jeong, Ambrose Seo, Woo Seok Choi, Jong Seok Lee Nov 2024

Engineering The Coherent Phonon Transport In Polar Ferromagnetic Oxide Superlattices, In Hyeok Choi, Seung Gyo Jeong, Do-Gyeom Jeong, Ambrose Seo, Woo Seok Choi, Jong Seok Lee

Chemical and Materials Engineering Faculty Publications

Artificial superlattices composed of perovskite oxides serves as an essential platform for engineering coherent phonon transport by redefining the lattice periodicity, which strongly influences the lattice-coupled phase transitions in charge and spin degrees of freedom. However, previous methods of manipulating phonons have been limited to controlling the periodicity of superlattice, rather than utilizing complex mutual interactions that are prominent in transition metal oxides. In this study on oxide superlattices composed of ferromagnetic metallic SrRuO3 and quantum paraelectric SrTiO3 , phonon modulation by controlling the geometry of superlattice in atomic-scale precision is realized, demonstrating the coherent phonon engineering using structural and …


Impact Of Gut Microbiota And Its Metabolites On Immunometabolism In Colorectal Cancer, Madison Flory, Paloma Bravo, Asfaqul Alam Nov 2024

Impact Of Gut Microbiota And Its Metabolites On Immunometabolism In Colorectal Cancer, Madison Flory, Paloma Bravo, Asfaqul Alam

Markey Cancer Center Faculty Publications

Colorectal cancer (CRC) is highly prevalent, accounting for approximately one-tenth of cancer cases and deaths globally. It stands as the second most deadly and third most common cancer type. Although the gut microbiota has been implicated in CRC carcinogenesis for the last several decades, it remains one of the least understood risk factors for CRC development, as the gut microbiota is highly diverse and variable. Many studies have uncovered unique microbial signatures in CRC patients compared with healthy matched controls, with variations dependent on patient age, disease stage, and location. In addition, mechanistic studies revealed that tumor-associated bacteria produce diverse …


Assessment Of Hemoglobin Concentration In Sows And Their Offspring Over Consecutive Reproductive Cycles, Katlyn A. Mcclellan, Merlin D. Lindemann, Crystal L. Levesque Nov 2024

Assessment Of Hemoglobin Concentration In Sows And Their Offspring Over Consecutive Reproductive Cycles, Katlyn A. Mcclellan, Merlin D. Lindemann, Crystal L. Levesque

Animal and Food Sciences Faculty Publications

Objective: Evaluate hemoglobin concentration (HbC) in sows and their offspring over consecutive parities. Materials and methods: Twenty-three females were monitored for HbC during parities 1, 2, and 3 at 7 timepoints (30 [± 2], 60 [± 2], 90 [± 2], and 112 days of gestation, 2 and 16 [± 1] days of lactation, and 5 [± 1] days post weaning). Piglet HbC was measured within 18 hours after birth and at 16 (± 1) days of age. Pigs were classified as anemic (HbC < 10 g/dL) or nonanemic (HbC ≥ 10 g/dL) at each timepoint. Results: On gestation day 90, 71.1% of sows were anemic across parities. In parity 1, HbC was less on lactation day 16 than all gestational timepoints (P < .001). In parity 2, HbC on lactation days 2 and 16 was less than all gestational timepoints (P < .001). In parity 3, HbC on lactation days 2 and 16 was less than gestation days 30 and 60 (P = .015). Piglet anemia prevalence at 1 day of age was 55.8%, 36.3%, and 46.1% for parity 1, 2, and 3, respectively (X2 < .001). Piglet anemia prevalence at 16 days of age was 35.6%, 18.7%, and 15.9% for parity 1, 2, and 3, respectively (X2 < .001). Implications: Decreasing sow HbC over the reproductive cycle and lack of post-weaning recovery in parity 3 indicates iron declines with advancing parity and may impact long-term health. Piglet anemia prevalence declined with advancing parity, suggesting a need to reevaluate piglet iron supplementation in litters from younger females.


Health Literacy And Perceived Control: Intermediary Factors In The Relationship Between Race And Cardiovascular Disease Risk In Incarcerated Men In The United States, Jennifer L. Miller, Misook L. Chung, Lovoria B. Williams, Alison R. Connell, Zyad T. Saleh, Abdullah S. Alhurani, Alison L. Bailey, Mary Kay Rayens, Debra K. Moser Nov 2024

Health Literacy And Perceived Control: Intermediary Factors In The Relationship Between Race And Cardiovascular Disease Risk In Incarcerated Men In The United States, Jennifer L. Miller, Misook L. Chung, Lovoria B. Williams, Alison R. Connell, Zyad T. Saleh, Abdullah S. Alhurani, Alison L. Bailey, Mary Kay Rayens, Debra K. Moser

UK CARES Faculty Publications

Background: Black race, inadequate health literacy, and poor perceived control are predictors of increased cardiovascular disease (CVD) risk. The purpose of this study was to explore the relationships among race, health literacy, perceived control, and CVD risk while controlling for known risk factors in incarcerated men. Methods: We included data from 349 incarcerated men to examine race and CVD risk (Framingham Risk Score) using a serial mediation model with health literacy and perceived control using 95% confidence intervals (CIs) from 5000 bootstrap samples. Results: Of the participants (age, 36 ± 10; education, 12 ± 2; body mass index, 28.3 ± …


Open Access In The Age Of Ai: The Journal Of Appalachian Health And Hurricane Helene Recovery, Noah Wren, Bradley Firchow Oct 2024

Open Access In The Age Of Ai: The Journal Of Appalachian Health And Hurricane Helene Recovery, Noah Wren, Bradley Firchow

Journal of Appalachian Health

The recent destruction brought upon the Appalachian region by Hurricane Helene has emphasized the importance of the Journal of Appalachian Health. As an open-access peer-reviewed source of information, the Journal plays a critical role in not only facilitating public health research about Hurricane Helene, but also combating misinformation regarding the event. In the days following Hurricane Helene, misinformation about the federal government’s response, along AI generated images, have left many in the region confused and misled about what had happened. Going forward, the Journal will play an necessary part in making sure accurate information is shared to understand how …


Reviewer Acknowledgements, Randy Wykoff, Emily Wilson Oct 2024

Reviewer Acknowledgements, Randy Wykoff, Emily Wilson

Journal of Appalachian Health

We at the Journal of Appalachian Health would like to thank the multitude of reviewers who have volunteered their time, talents, and attention to the journal. Reviewers help us consider the rigor and quality of the submissions we receive, and their willingness to read material ahead of publication ensures we can bring timely research to our readers in Appalachia and further afield.


Impacts Of The Covid-19 Pandemic On Intimate Partner Violence And Child Maltreatment Services In Rural Northwest North Carolina, Elisabeth G. Galphin, Adam Hege, Amy Dellinger Page Oct 2024

Impacts Of The Covid-19 Pandemic On Intimate Partner Violence And Child Maltreatment Services In Rural Northwest North Carolina, Elisabeth G. Galphin, Adam Hege, Amy Dellinger Page

Journal of Appalachian Health

The current study examined the impact of the COVID-19 pandemic on IPV and child maltreatment services in rural northwestern North Carolina. Qualitative interviews were conducted with eight professionals representing six service organizations across four counties. The findings highlighted challenges these agencies faced throughout the pandemic, new risks for the clients served, and positive outcomes. In addition, it has been a useful learning experience as public health and social service agencies learn to serve their communities more effectively moving forward. This is especially relevant for rural communities, as it has put public health preparedness at the forefront.