Digital Commons Network^™

A Pilot Study: Attention Deficit Hyperactivity Disorder, Sensation Seeking, And Pubertal Changes, Catherine A. Martin, Greg Guenthner, Christopher Bingcang, W. Jackson Smith, Thomas E. Curry, Hatim A. Omar, Mary Kay Rayens, Tom H. Kelly

Pediatrics Faculty Publications

This study was designed to examine the relationship of pubertal changes and sensation seeking (SS) in adolescents with Attention Deficit Hyperactivity Disorder (ADHD). Patients with current or past histories of uncomplicated stimulant medication use for ADHD between the ages of 11 and 15 (13 ± 1.5) were recruited from a Child Psychiatry and a General Pediatric Clinic. SS was measured using the SS Scale for Children. Pubertal development was measured using Tanner staging, free testosterone, and DHEAS. Subjects and their parent were interviewed with the Diagnostic Interview Schedule for Children (DISC). SS total score was correlated with Tanner stage, free …

Nucleic Acids Encoding Sarcocystis Neurona Antigen And Uses Thereof, Daniel K. Howe

Veterinary Science Faculty Patents

The present invention provides novel isolated nucleic acids encoding antigenic proteins derived from Sarcocystis neurona, or unique fragments thereof. In particular, the invention provides novel isolated nucleic acids encoding membrane-associated polypeptides SnSAG2, SnSAG3, and SnSAG4. Also provided are purified antigenic polypeptide fragments encoded by the novel nucleic acid sequences set forth herein that encode for SnSAG2, SnSAG3, and SnSAG4. Also provided are isolated nucleic acids capable of selectively hybridizing with the nucleic acid from Sarcocystis neurona. The invention also provides vectors comprising the nucleic acids of the invention encoding an antigenic protein derived from Sarcocystis neurona or …

Selective Parp-1 Targeting For Designing Chemo/Radio Sensitizing Agents, Marcos Oliveira

Pharmaceutical Sciences Faculty Patents

Poly(ADP-ribose) polymerase-1 (PARP-1) is a central signaling enzyme in a cell nucleus. PARP-1 is a target for the development of radio and chemo sensitizing agents in cancer treatment as well as providing protection from stroke. An SH3 domain and an SH3 ligand domain have now been discovered on the PARP-1 protein. These domains are involved in PARP-1 activation. This discovery makes possible the use of bioinformatics tools for the design of new drugs and strategies for drug target selection, specifically targeting the PARP-1 enzyme.

Workers Killed In Falls From Ladders, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Falls

To prevent falls from ladders while working:

• Make sure that an extension or straight ladder are erected according to the “4 to 1” rule of thumb.
• Safe work practices should be established by the employer for ascending and descending extension or straight ladders with materials and/ or equipment.
• All non-self-supporting ladders should be secured at the top and stabilized at the bottom.
• While working from ladders, workers should wear appropriate footwear.

Adverse Impact Of A History Of Violence For Women With Breast, Cervical, Endometrial, Or Overian Cancer, Susan C. Modesitt, Alisa C. Gambrell, Hope M. Cottrill, Lon R. Hays, Robert J. Walker, Brent J. Shelton, Carol E. Jordan, James E. Ferguson

Office for Policy Studies on Violence Against Women Publications

The experience of physical and sexual violence (victimization) is common among U.S. women and is associated with adverse health consequences. The study objectives were to estimate the prevalence of victimization in women with cancer and to examine associations with demographics, cancer screening, and cancer stage.

METHODS:

From 2004 to 2005, 101 women with breast, cervical, endometrial, or ovarian cancer were interviewed to collect demographics, cancer screening history, health care access/use, and violence history. Chisquare and Fisher exact tests were used test risk-factor associations. A multinomial logistic regression model was used for multivariable analysis.

RESULTS:

The prevalence of a history of …

Why Dentists Should Become Oral Physicians: A Response To Dr. Donald Giddon's "Why Dentists Should Be Called Oral Physicians Now", David A. Nash

Oral Health Science Faculty Publications

No abstract provided.

Incidence Of Galactorrhea In Young Women Using Depot-Medroxyprogesterone Acetate, Hatim A. Omar, Rana M. Zakharia, Shibani Kanungo, Marlene B. Huff, Kimberly K. Mcclanahan

Pediatrics Faculty Publications

Galactorrhea is rarely mentioned as a possible side effect of the use of Depot-Medroxyprogesterone Acetate (DMPA). Over the last few years, we have noticed an increased number of patients complaining of galactorrhea. A review of clinical data showed that between 1999 and 2005, 360 adolescents in our clinic used DMPA for at least 6 months. After medical follow-up, 13 (3.6%) of these patients were found to have developed galactorrhea. The mean age of the patients was 19.4 years with a range from 13-24. Prolactin levels in these patients were normal, and in all subjects, the galactorrhea resolved spontaneously within the …

Passenger Dies When Semi-Truck Trailer Hits Cow In Roadway, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On November 8, 2005, a 26-year-old male laborer who was a passenger in a semi-truck died when the driver swerved to avoid hitting a cow that was standing in the parkway lane. The two employees had been traveling westbound for approximately one hour when the driver noticed a cow in his lane. He swerved to avoid hitting the cow but hit it anyway. The tractor and two trailers jack-knifed, traveled through the median with the cab and trailers flipped onto their right sides, slid across the eastbound lanes, then the cab slammed through the guardrail. The cab came to rest …

Library Liaisons Enhance Researcher Productivity By Use Of A Common Bibliographic Management Software Interface To Deliver Current Awareness Information, Frank Davis, Rick Brewer, Carla Townsend

Library Presentations

Deliver quality-filtered full database records to faculty and staff in a customized format that can be easily imported into a common software interface. This allows both widespread individual and shared use of information for patient care, education, research, and publication.

The Welding Fume Case And The Preemptive Effect Of Osha’S Hazcom Standard On Common Law Failure-To-Warn Claims, Richard C. Ausness

Law Faculty Scholarly Articles

The Occupational Health and Safety Act (the OSH Act) affects more than ninety million workers in the United States. The OSH Act is administered by the Occupational Health and Safety Administration (OSHA), which promulgates health and safety standards for the workplace. Although OSHA standards do not regulate product manufacturers directly, they may affect liability when manufacturers are sued by workers who are injured by allegedly defective products provided by their employers. With increasing frequency, manufacturers are contending that the OSH Act or OSHA standards preempt these claims. In particular, manufacturers argue that the Hazard Communication Standard (HazCom Standard) should preempt …

Shelling Out For Genomics, Timothy S. Mcclintock, Charles D. Derby

Physiology Faculty Publications

A report on the symposium 'Genomic and Proteomic Approaches to Crustacean Biology' held as part of the Society for Integrative and Comparative Biology 2006 Annual Meeting, Orlando, USA, 4-8 January 2006.

Iodine Uptake Restoration In Thyroid Cancer, Kenneth B. Ain, Gopalakrishnan Venkataraman

Internal Medicine Faculty Patents

A method of expressing a tumor specific therapeutic response element in a cancerous cell is disclosed in which the response element was previously blocked from expression. The method comprises the step of administering an unblocking agent to the cancerous cell harboring a gene encoding the response element, thereby resulting in the expression of the response element.

Prenatal Cocaine Exposure Alters Alpha2 Receptor Expression In Adolescent Rats, Rosemarie M. Booze, David R. Wallace, Janelle M. Silvers, Barbara J. Strupp, Diane M. Snow, Charles F. Mactutus

Neuroscience Faculty Publications

BACKGROUND: Prenatal cocaine exposure produces attentional deficits which to persist through early childhood. Given the role of norepinephrine (NE) in attentional processes, we examined the forebrain NE systems from prenatal cocaine exposed rats. Cocaine was administered during pregnancy via the clinically relevant intravenous route of administration. Specifically, we measured alpha2-adrenergic receptor (alpha2-AR) density in adolescent (35-days-old) rats, using [3H]RX821002 (5 nM).

RESULTS: Sex-specific alterations of alpha2-AR were found in the hippocampus and amygdala of the cocaine-exposed animals, as well as an upregulation of alpha2-AR in parietal cortex.

CONCLUSION: These data suggest that prenatal cocaine exposure results in a persistent alteration …

Pantyhose: Masking To Reveal, Jena Sher

disClosure: A Journal of Social Theory

No abstract provided.

The Corporate Body, David Nutt

disClosure: A Journal of Social Theory

No abstract provided.

Disclosure Interviews Ida Susser. Women's Autonomy And The Political Contours Of Hiv/Aids In Southern Africa

disClosure: A Journal of Social Theory

No abstract provided.

Artistic Expression, Intimacy, And The Primal Holon: Sam Shepard's Suicide In B-Flat And The Tooth Of Crime, William S. Haney Ii

disClosure: A Journal of Social Theory

No abstract provided.

Spontaneous Intracranial Arterial Dissection In The Young: Diagnosis By Ct Angiography, William C. Robertson, Curtis A. Given

Neurology Faculty Publications

BACKGROUND: Spontaneous carotid artery dissections have been rarely reported in children. Diagnosis has traditionally been confirmed by catheter arteriography. More recently diagnosis has been made by magnetic resonance imaging and magnetic resonance angiography; however the sensitivity of these techniques has yet to be determined. The authors are unaware of reports of carotid dissection confirmed by dynamic computed tomography (computerized tomographic arteriography) in the young.

CASE PRESENTATION: We recently evaluated a fourteen year-old male following the development of transient neurologic symptoms. There was no antecedent illness or trauma. Dynamic computed tomography revealed an intracranial dissection involving the supraclinoid segment of the …

Biodiesel Basics, Czarena L. Crofcheck, Timothy S. Stombaugh, Michael D. Montross

Agricultural Engineering Extension Publications

Biodiesel is a renewable fuel for diesel engines. Biodiesel, defined by ASTM International (D6751), consists of longchain fatty acid alkyl esters and is made from renewable vegetable oils, recycled cooking oils, or animal fats. It can be used at full strength, but it is typically blended with petroleum diesel. A blend of 2 percent biodiesel and 98 percent diesel is referred to as B2. Other typical blends include B5, B10, and B20; pure biodiesel is sometimes referred to as B100. Biodiesel is safer for the environment and produces significantly less air pollution compared to petroleum diesel. Biodiesel can be produced …

Cyclooxygenase-2 Mediates Microglial Activation And Secondary Dopaminergic Cell Death In The Mouse Mptp Model Of Parkinson's Disease, Rattanavijit Vijitruth, Mei Liu, Dong-Young Choi, Xuan V. Nguyen, Randy L. Hunter, Guoying Bing

Neuroscience Faculty Publications

BACKGROUND: Accumulating evidence suggests that inflammation plays an important role in the progression of Parkinson's disease (PD). Among many inflammatory factors found in the PD brain, cyclooxygenase (COX), specifically the inducible isoform, COX-2, is believed to be a critical enzyme in the inflammatory response. Induction of COX-2 is also found in an experimental model of PD produced by administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

METHOD: COX-2-deficient mice or C57BL/6 mice were treated with MPTP to investigate the effects of COX-2 deficiency or by using various doses of valdecoxib, a specific COX-2 inhibitor, which induces inhibition of COX-2 on dopaminergic neuronal toxicity and …

Successful Treatment Of Depot Medroxyprogesterone Acetate-Related Vaginal Bleeding Improves Continuation Rates In Adolescents, Kristin M. Rager, Amy Fowler, Hatim A. Omar

Pediatrics Faculty Publications

High discontinuation rates for depot medroxyprogesterone acetate (DMPA) in adolescents may contribute to the number of unintended pregnancies. Many cite vaginal bleeding as a reason for discontinuing DMPA use. In this study, we attempted to determine if treating DMPA-associated vaginal bleeding with monophasic oral contraceptive pills (OCP) raised continuation rates. A total of 131 patients who reported vaginal bleeding while on DMPA were included in this study and 83 were treated with monophasic OCP. Of those who received OCP, 38.7% reported that vaginal bleeding stopped completely, 51.8% reported that vaginal bleeding stopped temporarily, and 6.0% reported no change. Overall, 94% …

Racial Disparity And Socioeconomic Status In Association With Survival In Older Men With Local/Regional Stage Prostate Cancer: Findings From A Large Community-Based Cohort, Xianglin L. Du, Shenying Fang, Ann L. Coker, Corinne Aragaki, Janice N. Cormier, Yan Xing, Beverly J. Gor, Wenyaw Chan

CRVAW Faculty Journal Articles

BACKGROUND

Few studies have examined the outcomes for Hispanic men with prostate carcinoma and incorporated socioeconomic factors in association with race/ethnicity in affecting survival, adjusting for factors on cancer stage, grade, comorbidity, and treatment.

METHODS

We studied a population-based cohort of 61,228 men diagnosed with local or regional stage prostate carcinoma at age 65 years or older between 1992 and 1999 in the 11 SEER (Surveillance, Epidemiology, and End Results) areas, identified from the SEER-Medicare linked data with up to 11 years of followup.

RESULTS

Low socioeconomic status was significantly associated with decreasing survival in all men with prostate carcinoma. …

Holistic Health: Does It Really Include Mental Health?, Kimberly K. Mcclanahan, Marlene B. Huff, Hatim A. Omar

Pediatrics Faculty Publications

Holistic health, incorporating mind and body as equally important and unified components of health, is a concept utilized in some health care arenas in the United States (U.S.) over the past 30 years. However, in the U.S., mental health is not seen as conceptually integral to physical health and, thus, holistic health cannot be realized until the historical concept of mind-body dualism, continuing stigma regarding mental illness, lack of mental health parity in insurance, and inaccurate public perceptions regarding mental illness are adequately addressed and resolved. Until then, mental and physical health will continue to be viewed as disparate entities …

Clinical Holistic Medicine: Holistic Sexology And Acupressure Through The Vagina (Hippocratic Pelvic Massage), Søren Ventegodt, Birgitte Clausen, Hatim A. Omar, Joav Merrick

Pediatrics Faculty Publications

Many gynecological and sexological problems (like urine incontinence, chronic pelvic pains, vulvodynia, and lack of lust, excitement, and orgasm) are resistant to standard medical treatment. In our work at the Research Clinic for Holistic Medicine in Copenhagen, we have found that vaginal acupressure, or Hippocratic pelvic massage, can help some of these problems. Technically, it is a very simple procedure as it corresponds to the explorative phase of the standard pelvic examination, supplemented with the patient's report on the feelings it provokes and the processing and integration of these feelings. Sometimes it can be very difficult to control the emotions …

Poster Session, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Limestone-Based Material for Arsenic Removal from Drinking Water, Chelsea Campbell and others, Dept of Chemistry, WKU
• Opportunistic Water Education, Amanda Abnee Gumbert, Extension Associate for Environmental and Natural Resources Issues, UK
• Ten-Year Solute Concentration Patterns in Two Streams of Contrasting Land-Use in Western Kentucky and Tennessee, Susan P. Hendricks, Hancock Biological Station, Murray State University
• Pathogen TMDL Development using Load Duration Curves for Two Stream Segments in Rockcastle County, Kentucky, Joseph M. Ferguson, Kentucky DOW
• Beargrass Creek Water Quality Tool and TMDLs, Ward Wilson and others, Tetra Tech
• Pathogen and Sediment Transport in Muddy Creek …

Session 2c: Planning, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• US EPA’s New Guidance on Watershed-Based Plans for Restoration and Protection, Barry Tonning, Tetra Tech, Mount Sterling, KY
• Louisville Water Company – Wellhead Protection Plan, Marsha L. Taylor Meyer, Louisville Water Company
• Lessons Learned Reforesting the Bluegrass, H. David Gabbard, LFUCG, Lexington, KY
• Low-Flow Characteristics of Streams in Kentucky, G.R. Martin, D.W. Evans, and K.R. Odom, USGS, Louisville

Session 1d: Monitoring, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• An Examination of Statewide Watershed Watch Project Monitoring Data for 2005 Using GIS, Ken Cooke, Kentucky Division of Water, Frankfort
• Taking Watershed Watch to the Next Level: Grabbing the Attention of Local Elected Officials, Ken Cooke, Kentucky Division of Water, H. David Gabbard, LFUCG, Lexington
• Water Quality Data from Citizen Monitoring in the Licking River Region Kentucky 1998-2005: Trends and Issues, M.F. Hult, Daniel Carter Beard Environmental Center, and B.C. Reeder, Center for Environmental Education, Morehead State University
• Water Quality in the Upper Licking River Basin 2003-2005, Brian Reeder and others, Dept of Biological and Environmental …

Session 1c: Superfund, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• The University of Kentucky Superfund Basic Research Program: Overview and Examples of Research Projects, Bernhard Hennig, Leonidas Bachas, and Lindell Ormsbee, UK
• Reductive Dechlorination of Toxic Organics by Bimetallic Nanoparticles in Polyacrylic Acid (PAA) Functionalized MF Membranes, Jian Xu and Dibakar Bhattacharyya, Dept Chemical and Materials Engineering, UK
• Chlorinated Organic Compounds Destruction by Modified Fenton Reaction Involving Immobilized Iron-Chelate, YongChao Li, Leonidas Bachas, and Dibakar Bhattacharyya, Dept Chemical and Materials Engineering, UK
• An Outreach Program Translates Basic Research for Superfund Communities to Improve Health through Nutrition, Lisa Gaetke and Sandra Bastin, Dept Nutrition and Food Science, …

Session 1b: Groundwater, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• A Brief History and Current State of Groundwater Protection in Kentucky, James Webb, Beverly Oliver, and Peter Goodmann, Kentucky DOW, Groundwater Branch
• Summary of Groundwater Quality Data in the Jackson Purchase Region, Kentucky, E.G. Beck, J.S. Dinger, and P.C. Inkenbrandt, KGS
• Groundwater-Quality Assessment and Shallow Aquifer Model of Calloway County, Kentucky, P.C. Inkenbrandt, E.G. Beck, and J.S. Dinger, KGS
• Suspended Sediment and Pathogen Transport in Two Inner Bluegrass Karst Ground-Water Basins, A.E. Fryar and others, Dept Earth and Environmental Sciences, UK
• Locating and Mapping Domestic Water Wells in Marshall County, Kentucky, Wendy D. Langhi, Western …

Session 1a: Water Quality, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Use of Sunfish and Stoneroller Minnows as Sentinel Monitors of PCB Contamination in Freshwater Streams in Kentucky, D.J. Price and W.J. Birge, Dept of Biology, UK
• Inferring Causes of Biological Impairment in Appalachian Streams: Watershed-Based Problem Formulation and Integration of Multiple Lines of Evidence, Jon Ludwig and others, Tetra Tech
• Relative Importance of Water and Dietary Cadmium: Toxicity to Ceriodaphnia Dubia, Agus Sofyan and W.J. Birge, Dept of Biology, UK
• The Graywater Story at Curtis Pike, Jack Kieffer and others, Appalachia - Science in the Public Interest, Mt. Vernon