Digital Commons Network^™

Functional Dissociation In Frontal And Striatal Areas For Processing Of Positive And Negative Reward Information, Xun Liu, David K. Powell, Hongbin Wang, Brian T. Gold, Christine R. Corbly, Jane E. Joseph

Neuroscience Faculty Publications

Reward-seeking behavior depends critically on processing of positive and negative information at various stages such as reward anticipation, outcome monitoring, and choice evaluation. Behavioral and neuropsychological evidence suggests that processing of positive (e.g., gain) and negative (e.g., loss) reward information may be dissociable and individually disrupted. However, it remains uncertain whether different stages of reward processing share certain neural circuitry in frontal and striatal areas, and whether distinct but interactive systems in these areas are recruited for positive and negative reward processing. To explore these issues, we used a monetary decision-making task to investigate the roles of frontal and striatal …

Development Of A Decision Support Tool To Facilitate Primary Care Management Of Patients With Abnormal Liver Function Tests Without Clinically Apparent Liver Disease [Hta03/38/02]. Abnormal Liver Function Investigations Evaluation (Alfie), Peter T. Donnan, David Mclernon, Douglas Steinke, Stephen Ryder, Paul Roderick, Frank M. Sullivan, William Rosenberg, John F. Dillon

Pharmacy Practice and Science Faculty Publications

BACKGROUND: Liver function tests (LFTs) are routinely performed in primary care, and are often the gateway to further invasive and/or expensive investigations. Little is known of the consequences in people with an initial abnormal liver function (ALF) test in primary care and with no obvious liver disease. Further investigations may be dangerous for the patient and expensive for Health Services. The aims of this study are to determine the natural history of abnormalities in LFTs before overt liver disease presents in the population and identify those who require minimal further investigations with the potential for reduction in NHS costs.

METHODS/DESIGN: …

Book Review: Davidson, Joyce, Liz Bondi And Mick Smith, Eds. 2005. Emotional Geographies. Ashgate Publishing, Burlington Vt., Mathias Detamore

disClosure: A Journal of Social Theory

No abstract provided.

Editor's Preface And Acknowledgements, Brandon Absher

disClosure: A Journal of Social Theory

No abstract provided.

The Health Implications Of Violence Against Women: Untangling The Complexities Of Acute And Chronic Effects: Part One, Carol E. Jordan

Office for Policy Studies on Violence Against Women Publications

No abstract provided.

Bridging The Critical Chasm Between Service And Research: The Cancer Information Service’S Collaboratory, Linda Squiers, Nigel Bush, Robin C. Vanderpool, Ludmila Cofta-Woerpel, Cecilia Fabrizio

Health, Behavior & Society Faculty Publications

As a collaboratory for cancer communication and education research, the National Cancer Institute's (NCIs) Cancer Information Service (CIS) is in an ideal position to bridge the critical chasm that exists between service and research. This article describes the CIS' current research program as well as the CIS Research Agenda launched in 2005. The CIS' progress in developing and supporting recently funded studies that address this agenda is detailed. The unique resources and opportunities available to researchers, public health practitioners, health care providers, and community-based organizations interested in developing collaborative cancer communication and cancer education studies with the CIS are identified …

Conspiracy Theories: Is There A Place For Civil Conspiracy In Products Liability Litigation?, Richard C. Ausness

Law Faculty Scholarly Articles

A civil conspiracy is a group of two or more persons acting together to achieve an unlawful objective or to achieve a lawful objective by unlawful or criminal means. During the past two decades, plaintiffs have brought numerous civil conspiracy claims against product manufacturers. The defendants in these cases have included manufacturers or producers of tobacco products, asbestos, pharmaceuticals, lead-based paint, multi-rim truck wheels, and gasoline additives. Surprisingly, less than half of the civil conspiracy claims have made it to trial. This unimpressive success rate suggests that courts are not very receptive to civil conspiracy claims even when there is …

Chronic Disease Prevention In Adolescence, Hatim A. Omar, Joav Merrick

Pediatrics Faculty Publications

No abstract provided.

Poster Session, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Identification of potential bacterial sources and levels, Red Duck Creek, Mayfield, Kentucky, Brooke Vorbeck, Travis Martin, and Mike Kemp, Dept of Industrial and Engineering Technology, Murray State University
• Water-quality trend analysis for streams in Kentucky, A.S. Crain and G.R. Martin, USGS, Louisville
• Preliminary Results of a Fecal Microbe Survey in a Eutrophic Lake, Wilgreen Lake, Madison County, Kentucky, W.S. Borowski and M.S. Albright, Depts of Earth Sciences and Geography, EKU
• Preliminary Physical and Chemical Characteristics of an Eutrophic Lake, Wilgreen Lake, Madison County, Kentucky, E.C. Jolly and W.S. Borowski, Dept of Earth Sciences, EKU
• Lethal and …

Session 2d: Superfund, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Challenges and Opportunities in Working Directly with Affected Superfund Communities in Kentucky, Lisa Gaetke, Nutrition and Food Science, UK
• Selected Chloro-Organic Detoxifications by Poly-Chelate (polyacrylic acid) and Citrate-Based Fenton Reaction at Neutral pH Environment, YongChao Li, L. G. Bachas, and Dibakar Bhattacharyya, Depts of Chemical & Materials Engineering and Chemisty, UK
• Reductive Degradation of Cholorinated Organics by Membrane-Supported Nonoparticles, Jian Xu and Dibakar Bhattacharyya, Dept of Chemical & Materials Engineering, UK

Session 2b: Goundwater, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Kentucky Groundwater-Quality Mapping Service, R.S. Fisher and Bart Davidson, KGS
• Kentucky Groundwater-Quality Data Search Engine, Bart Davidson and R.S. Fisher, KGS
• Water Quality in the Karst Terrane of the Sinking Creek Basin, Kentucky 2004-06, Angela S. Crain, USGS, Louisville
• Salt Movement Through the Vadose Zone of a Karst Soil – First Experiences with a Transfer Function Approach, Ole Wendroth and others, Dept Plant and Soil Sciences, UK

Session 1c: Epscor Projects, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Colloidal Arsenic in Poultry-Litter Amended Soils, Lisa Y. Blue and others, Dept of Chemistry, UK
• Environmental Monitoring and Assessment of Arsenic Metal in Groundwater Samples from Ballard, Carlisle, and Graves Counties, Kentucky, H.B. Fannin and others, Dept of Chemistry, Murray State University
• Environmental Monitoring and Assessment of the Groundwater Quality in Calloway County, Kentucky, Dan Kotter and others, KGS, Henderson, KY
• Land-Use Effects on Water Quality Within Lower Howard Creek Watershed, Southwestern Clark County, Kentucky, S.D. Daugherty and J.S. Dinger, Dept Earth & Environmental Sciences and KGS, UK

Session 1a: Microbial Source Tracking, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Detecting Multiple Source Origins from Fecal Bacteria Antibiotic Resistance Patterns, Sloane Ritchey and M.S. Coyne, Environmental Research Institute, EKU and Dept of Plant and Soil Sciences, UK
• Microbial Source Tracking; Limits and Application, Steve Evans, Third Rock Consultants, Lexington
• Triplett Creek Focus Study, Brian Reeder and April Haight, Institute for Regional Analysis and Public Policy, Morehead State University

Proceedings Of 2007 Kentucky Water Resources Annual Symposium, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

This conference was planned and conducted as part of the state water resources research annual program with the support and collaboration of the Department of the Interior, U.S. Geological Survey and the University of Kentucky Research Foundation, under Grant Agreement Number 06HQGR0087.

The views and conclusions contained in this document and presented at the symposium are those of the abstract authors and presenters and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the U.S. Government or other symposium organizers and sponsors.

Adrb2 Arg16gly Polymorphism, Lung Function, And Mortality: Results From The Atherosclerosis Risk In Communities Study, Jill M. Ferdinands, David M. Mannino, Marta L. Gwinn, Molly S. Bray

Internal Medicine Faculty Publications

BACKGROUND: Growing evidence suggests that the Arg16Arg genotype of the beta-2 adrenergic receptor gene may be associated with adverse effects of beta-agonist therapy. We sought to examine the association of beta-agonist use and the Arg16Gly polymorphism with lung function and mortality among participants in the Atherosclerosis Risk in Communities study.

METHODOLOGY AND PRINCIPAL FINDINGS: We genotyped study participants and analyzed the association of the Arg16Gly polymorphism and beta-agonist use with lung function at baseline and clinical examination three years later and with all-cause mortality during 10 years of follow-up. Lung function was characterized by percent-predicted forced expiratory volume in 1 …

Sociodemographic Characteristics And Diabetes Predict Invalid Self-Reported Non-Smoking In A Population-Based Study Of U.S. Adults, Monica A. Fisher, George W. Taylor, Brent J. Shelton, Sara M. Debanne

Markey Cancer Center Faculty Publications

BACKGROUND: Nearly all studies reporting smoking status collect self-reported data. The objective of this study was to assess sociodemographic characteristics and selected, common smoking-related diseases as predictors of invalid reporting of non-smoking. Valid self-reported smoking may be related to the degree to which smoking is a behavior that is not tolerated by the smoker's social group.

METHODS: True smoking was defined as having serum cotinine of 15+ng/ml. 1483 "true" smokers 45+ years of age with self-reported smoking and serum cotinine data from the Mobile Examination Center were identified in the third National Health and Nutrition Examination Survey. Invalid non-smoking was …

Phase I And Phase Ii Ocular Metabolic Activities And The Role Of Metabolism In Ophthalmic Prodrug And Codrug Design And Delivery, Abeer M. Al-Ghananeem, Peter A. Crooks

Pharmaceutical Sciences Faculty Publications

While the mammalian eye is seldom considered an organ of drug metabolism, the capacity for biotransformation is present. Compared to the liver, the metabolic capabilities of the eye are minuscule; however, phase I and phase II metabolic activities have been detected in various ocular structures. The careful consideration of ocular tissue metabolic processes within the eye has important implications for controlling the detoxification of therapeutic agents and for providing the potential for site-specific bio-activation of certain drug molecules, thus enabling significant improvements in drug efficacy and the minimization of side-effect from either local or systemic drug delivery to the eye. …

Forage News [2007-03], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Alfalfa Awards
• 27^th Kentucky Alfalfa Conference
• Forages at KCA
• 2006 Hay Contest Winners
• Biotech Traits Can Improve Alfalfa
• Newly Updated: Grain and Forage Crop Guide For KY
• New Publication: Long Term Variety Test Summary
• AFGC Will Hold Its Annual Meeting This June in Pennsylvania
• Increase in Alfalfa Acreage & Yield
• Conversion from Corn to Grassland Provides Economic and Environmental Benefits to a Maryland Beef Farm
• Disc, Sickle Mowers Both Have Pluses
• Kentucky Farm Numbers
• Upcoming Events

Fatal Aerial Lift Injuries, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Motor Vehicle

To prevent injuries while working in aerial lifts:

• A “pre-job safety plan” should be developed for each job site and reviewed prior to each day on the job site.
• Mechanical checks should be performed on all equipment at each job site prior to each use.
• There should be communication between the worker in the elevated lift and ground control crew.
• Ensure that appropriate fall protection equipment is available and correctly used when working from elevations.
• Employees should work within job qualifications and job limits.

Characterization Of Dairy Milk House Waste Water In Kentucky, Anshu Singh, Czarena L. Crofcheck, Gail M. Brion

Biosystems and Agricultural Engineering Faculty Publications

This study focuses on characterization of milk house waste water from eight different farms in Kentucky. The farms were separated into three groups based on the number of cows: small (20-30), medium (30-60), and large (over 60 cows). Samples were collected once a month from four farms and twice a month from the remainder. Samples were analyzed for chemical, biochemical, and microbiological characteristics. Results indicated a large and significant variation in the chemical and microbiological characteristics between the farms. Farm size had a significant effect on the nutrient content of the waste water. Though samples exhibited seasonal variation, there was …

Evaluation Of Geophysical Methods And Geophysical Contractors On Four Projects In Kentucky, David L. Allen

Kentucky Transportation Center Research Report

This report details four geophysical testing projects that were conducted in Kentucky for the Kentucky Transportation Cabinet. The four projects were as follows: KY 101, Edmonson and Warren Counties, US 31-W, Elizabethtown Bypass, Hardin County, KY 61, LaRue County, and US 27, Pulaski County.

Two contractors conducted the investigations for this study and they were as follows: KY 101 – (PELA) Electrical Resistivity and Microgravity, US 31-W – (CCKS) Microgravity, KY 61 – (CCKS) Electrical Resistivity and Microgravity, and US 27 – (CCKS) Electrical Resistivity and Microgravity.

These two methods preformed well and this report recommends that these geophysical methods …

Alfalfa For Summer Grazing, John Johns

Kentucky Alfalfa and Stored Forage Conference

Alfalfa can make an excellent grazing forage for cattle in the summer as well as at other times of year provided that good grazing management is utilized. Alfalfa can be grazed very close to the ground but should not be grazed continuously. Initial regrowth after grazing comes from nutrient reserves in the root; therefore, a sufficient rest period or regrowth period without grazing must be allowed for these nutrients to be replenished. In summer, this rest period is 30 to 35 days. In adequate rest for root nutrient replenishment is not allowed, the plant will be weakened and stand life …

How The Alfalfa Plant Grows: Impact On Management, S. Ray Smith

Kentucky Alfalfa and Stored Forage Conference

Alfalfa is the premier forage crop with high yield, high forage quality, season long productivity, drought tolerance, and extended stand life. Alfalfa requires intensive management to insure that yield, quality, and stand life are maximized. It should be planted on deep, well drained soils and maintained with optimal fertilizer inputs. It also requires adequate rest periods between cutting for hay or grazing. Alfalfa can be prone to significant insect damage and stands may require insecticide treatments. There are many details to successfully managing an alfalfa stand, but if you understand how the plant grows then you will better understand the …

Teenage Pregnancy: Impact Of The Integral Attention Given To The Pregnant Teenager And Adolescent Mother As A Protective Factor For Repeat Pregnancy, Maria José Carvalho Sant'anna, Kepler Alencar Mendes Carvalho, Amanda Melhado, Verônica Coates, Hatim A. Omar

Pediatrics Faculty Publications

The purpose of this study was to evaluate the impact of the integral attention to the health of pregnant adolescents and adolescent mothers, having follow-up from the Integral Support Program for the Pregnant Teen (ISPPT), with the intention to determine quality of life and prevent repeat pregnancy. A prospective study comprised 85 adolescents attended by the ISPPT between January 2002 and June 2006 who participated in meetings during pregnancy with a multidisciplinary team that provided orientation concerning family planning, self-esteem, pregnancy prevention, motivation to continue education and/or work, and evaluate the postpartum mother-child relationship. The following were analyzed: education level, …

Improving Student Dentist Competencies And Perception Of Difficulty In Delivering Care To Children With Developmental Disabilities Using A Virtual Patient Module, Harold L. Kleinert, Carla Sanders, John Mink, David A. Nash, Jeff Johnson, Sara Boyd, Sandra Challman

Human Development Institute Faculty Publications

An interactive, multimedia, virtual patient module was designed and developed on compact disc (CD-ROM) to address the need for student dentists to increase their competence and decrease their perception of difficulty in caring for children with developmental disabilities. A development team consisting of pediatric dentistry faculty members, parents of children with developmental disabilities, an individual with a developmental disability, and educational specialists developed an interactive virtual patient case. The case involved a ten-year-old child with Down syndrome presenting with a painful tooth. Student dentists were required to make decisions regarding proper interactions with the child, as well as appropriate clinical …

Forage News [2007-02], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• 27th Kentucky Alfalfa Conference
• Forages at KCA
• Heart of America Grazing Conference
• AFGC in Pennsylvania
• 1st National Grass-Fed Beef Conference
• AFGC Update
• 2007 Variety Trial Reports Available
• Top Ten Agricultural Counties (2005)
• Top Ten Counties (2005)
• Transporting Hay to be Subject to New Regulations
• FDA: Hay Farmers Clear Of Records Law
• Hay Sampling
• Use of Feedstuffs by Livestock in the United States
• Upcoming Events

Human Visfatin Expression: Relationship To Insulin Sensitivity, Intramyocellular Lipids, And Inflammation, Vijayalakshmi Varma, Aiwei Yao-Borengasser, Neda Rasouli, Angela M. Bodles, Bounleut Phanavanh, Mi-Jeong Lee, Tasha Starks, Leslie M. Kern, Horace J. Spencer Iii, Robert E. Mcgehee Jr., Susan K. Fried, Philip A. Kern

Clinical and Translational Science Faculty Publications

Context: Visfatin (VF) is a recently described adipokine preferentially secreted by visceral adipose tissue (VAT) with insulin mimetic properties.

Objective: The aim of this study was to examine the association of VF with insulin sensitivity, intramyocellular lipids (IMCL), and inflammation in humans.

Design and Patients: VF mRNA was examined in paired samples of VAT and abdominal sc adipose tissue (SAT) obtained from subjects undergoing surgery. Plasma VF and VF mRNA was also examined in SAT and muscle tissue, obtained by biopsy from well-characterized subjects with normal or impaired glucose tolerance, with a wide range in body mass index (BMI) and …

The Effect Of Cpg-Odn On Antigen Presenting Cells Of The Foal, M. Julia B.F. Flaminio, Alexandre S. Borges, Daryl V. Nydam, David W. Horohov, Rolf Hecker, Mary Beth Matychak

Veterinary Science Faculty Publications

BACKGROUND: Cytosine-phosphate-guanosine oligodeoxynucleotide (CpG-ODN) has been used successfully to induce immune responses against viral and intracellular organisms in mammals. The main objective of this study was to test the effect of CpG-ODN on antigen presenting cells of young foals.

METHODS: Peripheral blood monocytes of foals (n = 7) were isolated in the first day of life and monthly thereafter up to 3 months of life. Adult horse (n = 7) monocytes were isolated and tested once for comparison. Isolated monocytes were stimulated with IL-4 and GM-CSF (to obtain dendritic cells, DC) or not stimulated (to obtain macrophages). Macrophages and DCs …

Public Health Performance, F. Douglas Scutchfield Md

Preventive Medicine and Environmental Health Presentations

No abstract provided.

Gendered Support Strategies Of The Elderly In The Gwembe Valley, Zambia, Lisa Cliggett

Anthropology Faculty Publications

No abstract provided.