Digital Commons Network^™

Some Thoughts On Health Department Accreditation, F. Douglas Scutchfield Md

Preventive Medicine and Environmental Health Presentations

No abstract provided.

State Of Health In Northern Kentucky: How We Compare, Why It Matters To Business, Michael E. Samuels, Elmer T. Whitler

Center of Excellence in Rural Health Presentations

County-level data is becoming increasingly important for rural health planning. This presentation analyzes the health of several northern Kentucky counties and the potential consequences for the region’s employers.

A Polyadenylation Factor Subunit Implicated In Regulating Oxidative Signaling In Arabidopsis Thaliana, Jingxian Zhang, Bala Subrahmanyam Addepalli, Kil-Young Yun, Arthur G. Hunt, Ruqiang Xu, Suryadevara Rao, Qingshun Q. Li, Deane L. Falcone

Kentucky Tobacco Research and Development Center Faculty Publications

BACKGROUND: Plants respond to many unfavorable environmental conditions via signaling mediated by altered levels of various reactive oxygen species (ROS). To gain additional insight into oxidative signaling responses, Arabidopsis mutants that exhibited tolerance to oxidative stress were isolated. We describe herein the isolation and characterization of one such mutant, oxt6.

METHODOLOGY/PRINCIPAL FINDINGS: The oxt6 mutation is due to the disruption of a complex gene (At1g30460) that encodes the Arabidopsis ortholog of the 30-kD subunit of the cleavage and polyadenylation specificity factor (CPSF30) as well as a larger, related 65-kD protein. Expression of mRNAs encoding Arabidopsis CPSF30 alone was able to …

Issues And Challenges Facing The Field Of Phssr, F. Douglas Scutchfield Md

Preventive Medicine and Environmental Health Presentations

No abstract provided.

Public Health Professional Organizational Data, F. Douglas Scutchfield Md

Preventive Medicine and Environmental Health Presentations

No abstract provided.

Adaptation And Mal-Adaptation To Ambient Hypoxia; Andean, Ethiopian And Himalayan Patterns, Guoqiang Xing, Clifford Qualls, Luis Huicho, Maria Rivera-Ch, Tsering Stobdan, Marat Slessarev, Eitan Prisman, Shoji Ito, Hong Wu, Angchuk Norboo, Diskit Dolma, Moses Kunzang, Tsering Norboo, Jorge L Gamboa, Victoria E. Claydon, Joseph Fisher, Guta Zenebe, Amha Gebremedhin, Roger Hainsworth, Ajay Verma, Otto Appenzeller

Physiology Faculty Publications

The study of the biology of evolution has been confined to laboratories and model organisms. However, controlled laboratory conditions are unlikely to model variations in environments that influence selection in wild populations. Thus, the study of "fitness" for survival and the genetics that influence this are best carried out in the field and in matching environments.

Therefore, we studied highland populations in their native environments, to learn how they cope with ambient hypoxia. The Andeans, African highlanders and Himalayans have adapted differently to their hostile environment.

Chronic mountain sickness (CMS), a loss of adaptation to altitude, is common in the …

Spatiotemporal Postural Control Deficits Are Present In Those With Chronic Ankle Instability, Patrick O. Mckeon, Jay Hertel

Physical Therapy Faculty Publications

BACKGROUND: Postural control deficits have been purported to be a potential contributing factor in chronic ankle instability (CAI). Summary forceplate measures such as center of pressure velocity and area have not consistently detected postural control deficits associated with CAI. A novel measurement technique derived from the dynamical systems theory of motor control known as Time-to-boundary (TTB) has shown promise in detecting deficits in postural control related to chronic ankle instability (CAI). In a previous study, TTB deficits were detected in a sample of females with CAI. The purpose of this study was to examine postural control in sample of males …

Long-Term Survival After Radical Prostatectomy Compared To Other Treatments In Older Men With Local Or Regional Prostate Cancer, Liqian Liu, Ann L. Coker, Xianglin L. Du, Janice N. Cormier, Charles E. Ford, Shenying Fang

CRVAW Faculty Journal Articles

Background

This study aimed to address long-term survival in a large population-based cohort of men with prostate cancer receiving radical prostatectomy compared to other treatments.

Methods

We studied 5,845 patients diagnosed with local/regional stage prostate cancer at age 65–74 in 1992 with comorbidity score

Results

Of 5,845 patients, 10-year all-cause survival rates were the highest for patients receiving radical prostatectomy (81.0%; 95% CI: 79.4–82.4%), followed by radical prostatectomy in combination with radiotherapy (67.6%; 62.0–72.5%), radiotherapy (60.5%; 58.3–62.6%), and were the lowest for watchful-waiting (50.7%; 47.5–53.8%). A similar pattern was found for 10-year prostate cancer-specific survivals by treatments. After adjusting for …

Aluminum Bioavailability From Basic Sodium Aluminum Phosphate, An Approved Food Additive Emulsifying Agent, Incorporated In Cheese, Robert A. Yokel, Clair L. Hicks, Rebecca L. Florence

Pharmaceutical Sciences Faculty Publications

Oral aluminum (Al) bioavailability from drinking water has been previously estimated, but there is little information on Al bioavailability from foods. It was suggested that oral Al bioavailability from drinking water is much greater than from foods. The objective was to further test this hypothesis. Oral Al bioavailability was determined in the rat from basic [26Al]-sodium aluminum phosphate (basic SALP) in a process cheese. Consumption of approximately 1g cheese containing 1.5% or 3% basic SALP resulted in oral Al bioavailability (F) of approximately 0.1% and 0.3%, respectively, and time to maximum serum 26Al concentration (Tmax) of 8-9h. These Al bioavailability …

Caffeine Use: Association With Nicotine Use, Aggression, And Other Psychopathology In Psychiatric And Pediatric Outpatient Adolescents, Catherine A. Martin, Circe Cook, John H. Woodring, Gretchen Burkhardt, Greg Guenthner, Hatim A. Omar, Tom H. Kelly

Psychiatry Faculty Publications

The objective of this study was to evaluate the relationship between caffeine use, other drug use, and psychopathology in adolescents, using self-report measures. The study group consisted of 132 adolescents (average age 14.01 ± 2.06 years, 52% female, 19% African American, 5% other categories, 76% Caucasian). Most (47%) were recruited from a child psychiatry clinic with emphasis on youth with disruptive disorders, with 35% from an adolescent pediatric clinic with emphasis on prevention of risk-taking behavior and 18% from a pediatric clinic for families with limited resources. Subjects were consecutively recruited before or after regular clinic visits. Consent was obtained …

Designing A Successful Practice-Based Research Network In Public Health: Key Concepts, Glen P. Mays, Sharla A. Smith

Health Management and Policy Reports

Successful public health practice-based research networks (PBRNs) will require organizational, financial, and intellectual resources that allow practitioners and researchers to mount relevant studies in real-world public health settings. This brief outlines characteristics likely to be important to the success of public health PBRNs, based on the experience of PBRNs in other practice settings

Assessment Of Physician Workforce Supply And Demand In The Us, Michael E. Samuels, Elmer T. Whitler

Center of Excellence in Rural Health Presentations

Rural community and migrant health centers face major problems in attracting and retaining physicians. This presentation addresses that issue by projecting health services demands, physician specialty distribution and physician supply, as well as suggesting methods for increasing physician supply and reducing consumer demand.

2,6-Disubstituted Piperidines And Piperazine Compounds, Peter A. Crooks, Linda P. Dwoskin, Marlon D. Jones, Dennis Keith Miller, Seth Davin Norholm, Guangrong Zheng, Sairam Krishamurthy

Pharmaceutical Sciences Faculty Patents

The preparation of novel microemulsions to be used as precursors for solid nanoparticles is described. The microemulsion precursors consist of either alcohol-in-fluorocarbon microemulsions, liquid hydrocarbon-in-fluorocarbon microemulsions, or liquid hydrocarbon-in-water microemulsions. The formed solid nanoparticles have diameters below 200 nanometers and can be made to entrap various materials including drugs, magnets, and sensors. The solid nanoparticles can be made to target different cells in the body by the inclusion of a cell-specific targeting ligand. Methods of preparing the novel microemulsion precursors and methods to cure solid nanoparticles are provided.

A Bbp-Mud2p Heterodimer Mediates Branchpoint Recognition And Influences Splicing Substrate Abundance In Budding Yeast, Qiang Wang, Li Zhang, Bert C. Lynn, Brian C. Rymond

Biology Faculty Publications

The 3′ end of mammalian introns is marked by the branchpoint binding protein, SF1, and the U2AF65-U2AF35 heterodimer bound at an adjacent sequence. Baker's yeast has equivalent proteins, branchpoint binding protein (BBP) (SF1) and Mud2p (U2AF65), but lacks an obvious U2AF35 homolog, leaving open the question of whether another protein substitutes during spliceosome assembly. Gel filtration, affinity selection and mass spectrometry were used to show that rather than a U2AF65/U2AF35-like heterodimer, Mud2p forms a complex with BBP without a third (U2AF35-like) factor. Using mutants of MUD2 and BBP, we show that the BBP–Mud2p complex bridges partner-specific Prp39p, Mer1p, Clf1p …

Surgical Treatment Of A Rare Primary Renal Carcinoid Tumor With Liver Metastasis, Roberto Gedaly, Hoonbae Jeon, Thomas D. Johnston, Patrick P. Mchugh, Randall G. Rowland, Dinesh Ranjan

Surgery Faculty Publications

BACKGROUND: Carcinoid tumors are characteristically low grade malignant neoplasms with neuroendocrine differentiation that arise in various body sites, most commonly the lung and gastrointestinal tract, but less frequently the kidneys, breasts, ovaries, testes, prostate and other locations. We report a case of a carcinoid of renal origin with synchronous single liver metastases on radiological studies.

CASE PRESENTATION: A 45 year-old patient who presented with abdominal pain was found on CT scan to have lesions in the right ovary, right kidney, and left hepatic lobe. CA-125, CEA, and CA 19-9 were within normal limits, as were preoperative liver function tests and …

Assessment Of A Non-Invasive High-Throughput Classifier For Behaviours Associated With Sleep And Wake In Mice, Kevin D. Donohue, Dharshan C. Medonza, Eli R. Crane, Bruce F. O'Hara

Biology Faculty Publications

This work presents a non-invasive high-throughput system for automatically detecting characteristic behaviours in mice over extended periods of time, useful for phenotyping experiments. The system classifies time intervals on the order of 2 to 4 seconds as corresponding to motions consistent with either active wake or inactivity associated with sleep. A single Polyvinylidine Difluoride (PVDF) sensor on the cage floor generates signals from motion resulting in pressure. This paper develops a linear classifier based on robust features extracted from normalized power spectra and autocorrelation functions, as well as novel features from the collapsed average (autocorrelation of complex spectrum), which characterize …

Neo-Liberalism And Family Values In 1990s Immigration Reform Discourse, Christina Gerken

disClosure: A Journal of Social Theory

No abstract provided.

Cervical Screening And General Physical Examination Behaviors Of Women Exposed In Utero To Diethylstilbestrol, Elizabeth A. Camp, Ann L. Coker, Rebecca Troisi, Stanley J. Robboy, Kenneth L. Noeller, Karen J. Goodman, Linda T. Titus-Ernstoff, Elizabeth E. Hatch, Arthur L. Herbst, Raymond H. Kaufman, Ervin Adam

CRVAW Faculty Journal Articles

Objective. To estimate whether women exposed in utero to diethylstilbestrol (DES) report receiving more cervical and general physical examinations compared to unexposed women.

Materials and Methods. 1994 Diethylstilbestrol Adenosis cohort data are used to assess the degree of recommended compliance of cervical screenings found in 3,140 DES-exposed and 826 unexposed women. Participants were enrolled at 4 sites: Houston, Boston, Rochester, and Los Angeles. Logistic regression modeling was used to analyze mailed questionnaire data, which included reported frequency over the preceding 5 years (1990-1994) of Papanicolaou smears and general physical examinations.

Results. Diethylstilbestrol-exposed women exceeded the recommended frequency of Papanicolaou smear …

The Influence Of Citrate, Maltolate And Fluoride On The Gastrointestinal Absorption Of Aluminum At A Drinking Water-Relevant Concentration: A 26Al And 14C Study, Yuzhao Zhou, Wesley R. Harris, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

The objectives were to test the null hypotheses that (1) citrate, maltolate, and fluoride do not significantly influence oral Al bioavailability, C_max or T_max at an Al dose relevant to drinking water exposure; and (2) Al citrate and maltolate are absorbed intact from the gastrointestinal tract. Male Fisher rats were given 1 ml of solution intra-gastrically containing 1 nCi ²⁶Al (65 nmol total Al) as the Al³⁺ ion, or as complexes with ¹⁴C-citrate, ¹⁴C-maltolate or fluoride, during concurrent ²⁷Al iv infusion. Blood was repeatedly collected for serum ²⁶Al, total Al and ^{14 …}

High Status Men (But Not Women) Capture The Eye Of The Beholder, C. Nathan Dewall, Jon K. Maner

Psychology Faculty Publications

Two studies tested the hypothesis that people attend preferentially to high status men (but not women). Participants overestimated the frequency of high status men in rapidly presented arrays (Experiment 1) and fixated their visual attention on high status men in an eye-tracking study (Experiment 2). Neither study showed any evidence of preferential attention to high status women, but there was evidence that physically attractive women captured attention. The results from both studies support evolutionary theories regarding differential prioritization of social status and physical attractiveness in men versus women. These findings illustrate how examination of early-in-the-stream social cognition can provide useful …

Preventing Cardiovascular Disease In Kentucky: Epidemiology, Trends, And Strategies For The Future, Sarah Sartini Rugg, Alison L. Bailey, Steven R. Browning

Internal Medicine Faculty Publications

Cardiovascular disease (CVD) is the leading cause of death in the United States despite dramatic improvements in the treatment of heart disease in recent years. Kentucky leads the nation in the prevalence of several individual risk factors for cardiovascular disease, the prevalence of multiple risk factors, and in cardiovascular mortality. While trends in the prevalence of some of these cardiac risk factors have shown improvement, others have remained unchanged or have worsened. The increased prevalence of obesity and diabetes, especially among young persons, is one of the most worrisome trends. The prevalence of smoking in Kentucky remains high, and has …

Giovanni Borelli’S De Motu Animalium, 1685, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

No abstract provided.

Differential Impacts Of Smoke-Free Laws On Indoor Air Quality, Kiyoung Lee, Ellen J. Hahn, Nick Pieper, Chizimuzo T.C. Okoli, James Repace, Adewale Troutman

Nursing Faculty Publications

The authors assessed the impacts of two different smoke-free laws on indoor air quality. They compared the indoor air quality of 10 hospitality venues in Lexington and Louisville, Kentucky, before and after the smoke-free laws went into effect. Real-time measurements of particulate matter with aerodynamic diameter of 2.5 µm or smaller (PM_2.5) were made. One Lexington establishment was excluded from the analysis of results because of apparent smoking violation after the law went into effect. The average indoor PM_2.5 concentrations in the nine Lexington venues decreased 91 percent, from 199 to 18 µg/m³. The average …

Semi-Tractor Trailer Driver Hauling Chicken Dies After Striking A Rock Wall, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On a sunny fall day in 2007, a 50-year old semi truck driver hauling processed frozen chicken in a refrigerated trailer, died when his semi crashed into a rock wall. The driver was north bound on an interstate highway when witnesses saw the semi in the left lane contact the concrete median barrier then veer over to the right across one traffic lane and the shoulder, then strike a rock wall. The impact caused the cab to overturn onto the driver’s door while the refrigerated trailer remained standing upright. An exhaust pipe located on the back of the cab was …

Opening Doors To Open Scholarship: A White Paper Exploring The Role Of A Digital Object Repository To Support And Preserve The University Of Kentucky’S Digital Assets, Lisa Carter, Mary H. Molinaro, Rebecca Ryder, Kathryn Lybarger, Beth Kraemer, Brian Helm, Mary Beth Thomson, John Soward, Deirdre Scaggs

Library Reports and White Papers

No abstract provided.

Semi Owner-Operator Dies In Rollover After Speeding Through A Curve, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On a Fall day in 2005 at 3:00 PM, a 46 year-old male semi-tractor trailer owner-operator was hauling logs when he rounded a curve, drove off the right side of a two lane state highway, struck a tree and rolled over. Emergency medical services were called to the scene. When they arrived, they found the driver without vital signs and contacted the local coroner. Kentucky State Police arrived and called Kentucky Vehicle Enforcement to the scene. The driver had not been wearing his seatbelt. Toxicology detected methamphetamine and doxylamine in his system at the time of the crash.

To prevent …

Poster Session, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Kentucky Water Awareness Month Packet, Ashley Osborne, UK Cooperative Extension Service, ENRI Task Force
• Recent Enhancements to the Kentucky Groundwater-Quality Data Search Engine, Bart Davidson and R. Stephen Fisher, KGS
• Diatom Colonization Patterns and Carbon Stable Isotopic Ratios in Developing Periphyton at Springs of Differing Geologic Origin in Land-Between-the-Lakes, Courtney Snapp and Susan Hendricks, Water Sciences Program, Murray State University
• Seasonal Changes in Stratification and Oxygen Content of a Eutrophic Lake, Wilgreen Lake, Madison County, Kentucky, Jill Hunter and Walter Borowski, Dept of Geography and Geology, EKU
• Water Pioneers Water Quality Program 2007, Stephanie Jenkins, …

Session 2c: Water Quality, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Determinations of Bioavailable Fractions in the Assessment of Metals in Big and Little Bayou Creeks……, McCracken County, Kentucky, David J. Price, Dept Biology, UK
• Creation of a Catalog of Environmental Mercury Databases in Kentucky, Caroline Chan and others, School of Public Health and Information Sciences, U of L
• Using Nitrogen Isotopes to Trace Nutrient Inputs to a Eutrophic Lake, Wilgreen Lake, Madison County, Kentucky, Walter Borowski and Theresa Aguiar, Dept of Geography and Geology, EKU
• Using Microbial Distribution and Abundance in a Eutrophic Lake as a Tracer for Nutrient Inputs, Wilgreen Lake, Madison County Kentucky, Theresa …

Session 1c: Student Research Projects, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• A 3-D Computational Fluid Dynamics Code for Simulation of Pump Stations with Vertical Plunging Jet and Air Bubble Transport, Tien Mun Yee and Scott Yost, Dept of Civil Engineering, UK
• Chemical Evolution of Groundwater in the Wilcox Aquifer of the Mississippi Embayment, Estifanos Haile and Alan Fryar, Dept of Earth and Environmental Sciences, UK
• Sediment Organic Matter Degradation within Storage Zones Deposited In-Stream, Charles Davis and Jimmy Fox, Dept of Civil Engineering, UK
• Effectiveness of Improved Skid Trail Headwater Stream Crossings, Jeffrey Stringer and Christopher Reeves, Dept of Forestry, UK

Session 1b: Education, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Community Based Science, Water Quality and Nonpoint Source Pollution, Carol Hanley and others, Tracy Farmer Center for the Environment, UK
• A Stormwater Education Program to Assist Kentucky’s MS4 Phase II Communities, Yvonne Meichtry and Julie Gee, Kentucky Transportation Cabinet, Frankfort
• Water/Wastewater Technician Training Institute: A Holistic Approach to Developing a Professional Water and Wastewater Workforce, Andrew Ernest, Center for Water Resource Studies, WKU
• Geology for Everyone, New Map Products from the Kentucky Geological Survey, Daniel Carey, KGS