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The Undiscovered Country: Execution Competency & Comprehending Death, Jeffrey L. Kirchmeier

Kentucky Law Journal

No abstract provided.

CoWho? Kentucky's Need To Statutorily Define Property Interests In Geologically Sequestered Carbon Dioxide, E. Chase Dressman

Kentucky Law Journal

No abstract provided.

Substrate And Regulation Of Mitochondrial Μ-Calpain, Aashish Joshi

University of Kentucky Doctoral Dissertations

μ -Calpain is localized to the mitochondrial intermembrane space. Apoptosisinducing factor (AIF), which executes caspase-independent cell death, is also localized to the mitochondrial intermembrane space. Following processing at the N-terminus, AIF becomes truncated (tAIF) and is released from mitochondria. The protease responsible for AIF processing has not been established. The same submitochondrial localization of mitochondrial μ-calpain and AIF gives support to the hypothesis that mitochondrial μ-calpain may be responsible for processing AIF. Atractyloside-induced tAIF release in rat liver mitochondria was inhibited by cysteine protease inhibitor MDL28170, but not by calpain inhibitors PD150606 or calpastatin. Moreover, μ-calpain immunoreactivity was difficult to …

Role Of Cyclophilin D In Secondary Spinal Cord And Brain Injury, Jordan Mills Clark

University of Kentucky Doctoral Dissertations

In the hours and days following acute CNS injury, a secondary wave of events is initiated that exacerbate spinal tissue damage and neuronal cell death. A potential mechanism driving these secondary events is opening of the mitochondrial permeability transition pore (mPTP) and subsequent release of several cell death proteins. Previous studies have shown that inhibition of cyclophilin D(CypD), the key regulating component in mPTP opening, was protective against insults that induce necrotic cell death. We therefore hypothesized that CypD-null mice would show improved functional and pathological outcomes following spinal cord injury (SCI) and traumatic brain injury (TBI). Moderate and severe …

Glutamate Regulation In The Hippocampal Trisynaptic Pathway In Aging And Status Epilepticus, Michelle Lee Stephens

University of Kentucky Doctoral Dissertations

A positive correlation exists between increasing age and the incidence of hippocampal-associated dysfunction and disease. Normal L-glutamate neurotransmission is absolutely critical for hippocampal function, while abnormal glutamate neurotransmission has been implicated in many neurodegenerative diseases. Previous studies, overwhelmingly utilizing ex vivo methods, have filled the literature with contradicting reports about hippocampal glutamate regulation during aging. For our studies, enzyme-based ceramic microelectrode arrays (MEA) were used for rapid (2 Hz) measurements of extracellular glutamate in the hippocampal trisynaptic pathway of young (3-6 months), late-middle aged (18 mo.) and aged (24 mo.) urethane-anesthetized Fischer 344 rats. Compared to young animals, glutamate terminals …

An Examination Of The Association Between Middle School Students' Perceptions Of Teacher Interactions, Home-School Dissonance, And School Attachment, Ruby Jewel Stevens

University of Kentucky Doctoral Dissertations

The purpose of this study was to investigate whether middle school students’ perceptions of teacher interactions and home-school dissonance are predictors of school attachment. The study sought to determine if there were differences in students’ perceptions of teacher interactions and home-school dissonance based on ethnicity, gender and/or grade level. This investigation is one of the first to explore the association between these variables.

Data for this investigation was obtained from a larger study where surveys were administered to over 800 racially diverse students in grades 6 through 8 in Language Arts classrooms in two public middle schools with diverse student …

The Association Between Alcohol Sales And County Level Economic Growth In Kentucky, Julia Hinkle Rollins

University of Kentucky Master's Theses

This thesis evaluates the effectiveness of using alcohol sales as an indicator of development or lag associated with development in Kentucky counties using summary statistics, shift-share analysis and an econometric model. The summary statistics are used to evaluate possible lines of causality and the Shift-share analysis and econometric model deal the specific characteristics of the county that are assumed to be influenced by the sale of alcohol. Limitations to the county level data were limiting to the time period evaluated in this thesis. As a result, much of the findings were inconclusive as to the relationship between county level economic …

School Lunch Programs And The American Diet: Exploring A Contested Food Terrain, Rebecca Som Castellano

University of Kentucky Master's Theses

This study examines the social actors and issues involved in constructing and contesting the National School Lunch Program (NSLP), in order to identify whose interests are involved in shaping an institution which transmits dietary habits and food knowledge to the nation’s children through the mid day meal.

For the historical analysis, I collected data from historical accounts of the NSLP, congressional hearings, laws, and newspaper articles. For the contemporary analysis, I interviewed 15 actors representing organizations key to federal NLSP policy making. To frame my analysis, I utilize a model of power, based on the work of Arts and Van …

Electrical And Mechanical Properties Of Mwcnt Filled Conductive Adhesives On Lead Free Surface Finished Pcb's., Keerthi Varma Mantena

University of Kentucky Master's Theses

Electrically conductive adhesives (ECA) are an alternative to tin/lead solders for attaching Surface Mount Devices (SMD) in electronic assemblies. ECAs are mixtures of a polymer binder (for adhesion) and conductive filler (for electrical conductivity). They bring more conductivity, higher strength, less weight and longer durability than metal alloys. ECAs can offer numerous advantages such as fewer processing steps, lower processing temperature and fine pitch capability. Multi walled carbon nanotubes (MWCNT) were used as conductive fillers in this research because of their novel electronic and mechanical properties.

The high aspect ratio of the nanotubes makes it possible to percolate at low …

Parental Choice Of Nondenominational Christian Education: Reasons For Choice, Exit, And The Types And Sources Of Information Used, Robert M. Hall

University of Kentucky Doctoral Dissertations

School Choice is a topic that finds itself at the top of school reform and political agendas across the United States, while also being a significant focal point in the educational literature. However, little attention in the debate has been placed on private, independent school choice – including private religious school choice – despite that data that shows “seventy-nine percent of all private schools had a religious affiliation in 1999– 2000: 30 percent . . . affiliated with the Roman Catholic Church, and 49 percent with other religious groups” (U.S. Department of Education, 2002, p. 3) and that “initial research …

An Evaluation Of The Traveling Wave Ultrasonic Motor For Force Feedback Applications, Nishant Venkatesan

University of Kentucky Master's Theses

The traveling wave ultrasonic motor is considered for use in haptic devices where a certain input-output relation is desired between the applied force and the resulting motion. Historically, DC motors have been the standard choice for this purpose. Owing to its unique characteristics, the ultrasonic motors have been considered an attractive alternative. However, there are some limitations when using the ultrasonic motor for force-feedback applications. In particular, direct torque control is difficult, and the motor can only supply torque in the direction of motion. To accommodate these limitations we developed an indirect control approach. The experimental results demonstrate that the …

Phenotypic And Genotypic Selection For Head Scab Resistance In Wheat, Andres Mateo Agostinelli

University of Kentucky Master's Theses

Fusarium Head Blight (FHB) is a destructive disease caused by Fusarium graminearum that affects wheat (Triticum aestivum L.) worldwide. Breeding for resistance to FHB is arguably the best way to combat this disease. However, FHB resistance is highly complex and phenotypic screening is difficult. Molecular markers are a promising tool but breeding programs face the challenge of allocating resources in such a way that the optimum balance between phenotypic and genotypic selection is reached.

An F_2:3 population derived from a resistant x susceptible cross was subjected to phenotypic and genotypic selection. For phenotyping, a novel air separation method …

Trinexapac-Ethyl And Overseeding Effects On Shear Strength And Tolerance To Simulated Traffic Of Four Bermudagrass Cultivars Grown On A Sand-Based System, Michael Todd Deaton

University of Kentucky Master's Theses

Bermudagrass (Cynodon dactylon L.) is often used for athletic fields due to its wear tolerance and recuperative ability. Studies were conducted May 2007 through November 2008 in Lexington, Kentucky. The cultivars ‘Quickstand’, ‘Tifway’, ‘Riviera’, and ‘Yukon’ grown in a sand-based medium were used to investigate differences in wear tolerance and shear strength. Trinexapac-ethyl (TE) was applied at label rates and frequencies or untreated. Overseeding treatments were perennial ryegrass (Lolium perenne L.) at 0, 612, and 1225 kg PLS ha^-1. Traffic treatments were applied with a Brinkman traffic simulator 3 d wk-1 August through October. Shear tests …

The Law V. The Stranger: Language Interpretation And Legal Space In Lexington, Ky, Karen S. Kinslow

University of Kentucky Master's Theses

This thesis examines the role of interpretation in legal encounter in Lexington, Kentucky. Through an analysis of legal and interpretation practices, this study seeks to ascertain how these practices may affect non-native or low-proficiency English speakers’ (LLPs) experiences with both federal and local laws and legal spaces. This place-based study involves in-depth qualitative research. Using the methodological framework of feminist geo-jurisprudence, this research contributes to our understanding of 1) the limits of the publicity of legal space and, more specifically, the ways in which language barriers can prevent legal inclusion; 2) local strategies and tactics for dealing with the challenges …

Role Of Mel-18 In Regulating Protein Sumoylation And Identification Of A New Polymorphism In Bmi-1, Jie Zhang

University of Kentucky Doctoral Dissertations

Small ubiquitin-like modifier (SUMO) regulates numerous biological functions. In a previous study we found that sumoylation of HSF2 is involved in regulating HSF2 bookmarking function, but the mechanism that mediates this regulation was unknown. The results in my work support the intriguing hypothesis that polycomb protein, Mel-18, actually functions as an anti-SUMO E3 protein, interacting both with HSF2 and the SUMO E2 Ubc9, but acting to inhibit Ubc9 activity and thereby decrease sumoylation of the HSF2.

This study also suggested that Mel-18 negatively regulates the sumoylation of other cellular proteins, and we extend its targets to RanGAP1 protein. The results …

Angiotensin Ii Induction Of Regional Effects In Murine Vasculature, Albert Phillip Owens Iii

University of Kentucky Doctoral Dissertations

The renin angiotensin system (RAS) exerts many diverse physiological functions throughout the body, mediated by its effector peptide, angiotensin II (AngII). AngII has been linked with a variety of different functions ranging from the initiation of severe vascular pathologies, such as atherosclerosis and abdominal aortic aneurysm (AAA), to mundane physiological processes of fluid homeostasis, vascular contraction, and regulation of blood pressure. To provide a potential link between these functions, an in-depth analysis of regional effects of AngII on aortic vasculature was performed.

The studies presented in this dissertation tested the overall hypothesis of whether regional changes exist in the vasculature …

Hip Muscle Strength And Pelvic Obliquity In Collegiate Females During Walking And Stair Descent Tasks, Kelly Rodriguez

University of Kentucky Master's Theses

The goals of the pelvis include maintaining the center of mass of the body, assisting in foot clearance and absorb forces from the lower extremities using muscles and ligaments to stabilize the joint. A better understanding of the influence of muscle strength on controlling pelvic obliquity in a healthy population will help in understanding low back pain and overuse lower extremity injuries. Thirteen females (22 ±2 yrs) participated in isokinetic strength testing of the hip abductors, adductors, internal rotators and external rotators on a Biodex dynamometer. The subjects also underwent gait analysis during self selected pace walking and stair descent. …

Coordination Of Swimbench Freestyle In Elite And Non-Elite Swimmers: A Dynamical System Approach, Tracy H. Spigelman

University of Kentucky Doctoral Dissertations

Elite swimmers can be distinguished from novice swimmers by freestyle stroke technique. Elite swimmers move through multiple coordination modes, increases in stroke lengths, stroke rates, and body roll allowing for a more symmetrical stroke and increased speed compared with novice swimmer during 100m freestyle.

Coaches strive to improve swimmers’ performance by providing feedback about stroke technique, mostly from the pool deck where view of the full stroke cycle is obstructed by the water. Tools to assess swimming are often expensive and require extra training, which does not provide a pragmatic solution. A dryland rotational swimbench would provide a means to …

Palestinian Refugee Women Of Jabaliya Camp, Occupied Gaza Strip: Everyday Acts Of Resistance And Avenues Of Empowerment, Sharon French Wallace

University of Kentucky Doctoral Dissertations

The lives of Palestinian refugee women are complex and layered, embedded in the constraints and dictates of a patriarchal class system within a conservative culture that has been shaped by resistance to the Israeli military occupation since 1948. Over six decades of Israeli military occupation, ongoing national resistance, poverty and a maledominated society are a few of the forces that continue to shape the lives of refugee women today. The Israeli occupation has obstructed the development of a viable Palestinian economy and legal institutions that could serve as a framework for attaining women’s rights. In addition, Palestinian women, especially refugee …

The Effects Of Roads On Space Use And Movements Of Black Bears In Eastern Kentucky, Rebekah A. Jensen

University of Kentucky Master's Theses

Kentucky, USA, is the site of recent natural recolonization by the American black bear (Ursus americanus); however, bears are rarely observed outside the Cumberland Mountains along the state‘s southeastern border. I examined the influence of roads in constraining the distribution of this population by altering animal space use and movement. I identified patterns of road avoidance and road crossing using data from Global Positioning System collars worn by 28 adult bears (16M, 12F), and described road mortality trends using 27 roadkill events. Bears avoided roads at the home range and landscape scale, primarily crossed low-traffic roads, and crossed …

The Role Of The Hip Abductor Muscle Complex In The Function Of The Pathological Hip Joint, Maureen Kelly Dwyer

University of Kentucky Doctoral Dissertations

The number of patients electing to undergo total hip arthroplasty (THA) in the United States has been projected to double by the year 2030, with a growing number of these patients below the age of 65 years. This cohort of patients not only desires to return to pain free daily activity, but wishes to participate in recreation and sporting activities. However, many of these patients report pain, impairments, and functional limitations following THA. The number one deficit observed for patients who fail conventional post-operative rehabilitation is persistent weakness of the hip abductor muscles. In order to safely progress these patients …

Human Ribosomal Rna Gene Clusters Are Recombinational Hotspots In Cancer, Dawn Michelle Stults

University of Kentucky Master's Theses

The gene that produces the precursor RNA transcript to the three largest ribosomal RNA molecules (rDNA) is present in multiple copies and organized into gene clusters. They represent 0.5% of the diploid human genome but are critical for cellular viability. The individual genes possess very high levels of sequence identity and are present in high local concentration, making them ideal substrates for genomic rearrangement driven by dysregulated homologous recombination. Our laboratory has developed a sensitive physical assay capable of detecting recombination-mediated genomic restructuring in the rDNA by monitoring changes in lengths of the individual clusters. In order to determine whether …

Adolphe Nourrit, Gilbert-Louis Duprez, And Transformations Of Tenor Technique In The Early Nineteenth Century: Historical And Physiological Considerations, Jason Christopher Vest

University of Kentucky Doctoral Dissertations

The April 1837 debut of tenor Gilbert-Louis Duprez at the Paris Opéra sparked uproarious applause and inspired a new group of tenors with a different vocal technique from tenors of the previous generation. Whereas previous tenors of the nineteenth century sang in a graceful, light, and flexible style that complemented the operatic compositions of Gluck, Rossini, and Bellini, Duprez sang in a powerful, forceful voice that brought new dramatic fervor to the existing repertoire of French Grand Opera. Duprez’ stentorian vocal representations of Arnold in Rossini’s Guillaume Tell and Robert in Meyerbeer’s Robert le diable, among others, inspired composers …

A Descriptive Study Of The Diet And Physical Activity Practices Of Overweight And Obese College Students Enrolled In A Weight Loss Program, Laura Brooke Walters

University of Kentucky Master's Theses

The effect of weight gain on college students may lead to physical and emotional problems that could continue into adulthood. Identifying behavioral, demographic, and psychological factors that impact college student’s weight status could aid in developing programs to help reduce weight and prevent weight gain in overweight and obese college students. This study evaluated the dietary habits, physical activity, and psychosocial characteristics of college students entering a university-sponsored weight loss program. Results suggest that the majority of participants have experienced weight gain in the past year and none have experienced weight loss. The student’s diets tended to include less than …

An Interaction Between Risk Perceptipton And Trust In Response To Food Safety Events Across Products And Regions, And Their Implicaitons For Agribusiness Firms, Jonathan D. Shepherd

University of Kentucky Master's Theses

Food safety events receive substantial media coverage and can create devastating economics losses for agribusiness firms. It is unclear what factors influence consumers’ purchasing decisions before or after a food safety event occurs. The objectives of this study is to identify these factors that influence purchasing decisions, determine how consumers respond to hypothetical food safety events, and compare these findings across different products and geographical regions. The data for this research was obtained from two surveys. One survey concerned fresh produce while the second focused on meat products. The SPARTA model, based on the Theory of Planned Behavior, is used …

Changes In Longitudinally Assessed Biomechanical Parameters Related To Increased Risk Of Anterior Cruciate Ligament (Acl) Injuries In Adolescent Female And Male Athletes, Kevin Ray Ford

University of Kentucky Doctoral Dissertations

Females suffer anterior cruciate ligament (ACL) injuries at a 2 to 10-fold greater rate compared to male athletes participating in similar sports. Altered movement patterns and inadequate knee stiffness are two interrelated factors that may increase ACL injury risk. Onset of these neuromuscular risk factors may coincide with the rapid adolescent growth that results in the divergence of a multitude of neuromuscular parameters between sexes. The overall purpose of this dissertation was to determine if neuromuscular ACL injury risk factors in female athletes increase following rapid growth and development compared to males. Male and female athletes were tested with three-dimensional …

Nutrient And Medication Intake Of Children With Neurodevelopmental Disorders, Cristina Elizabeth Hiten

University of Kentucky Master's Theses

The incidence of autism continues to rise with no cure or understanding of the cause of the disorder. Approximately one in 150 children will be diagnosed with an (ASD) Autism Spectrum Disorder although recent prevalence data suggest one in 91. The objective of the study is to assess medicinal intake regarding prescription and nonprescription medications of children with Autism Spectrum Disorders and its affect on their nutritional status compared to age, and sex matched healthy children. The study included families of children with autism in which they completed questionnaires and 24‐hour recalls. There were 26 children used within the questionnaire …

Low Density Lipoprotein Receptor And Alzheimers Disease, Rangaraj K. Gopalraj

University of Kentucky Doctoral Dissertations

Since apoE allele status is the predominant Alzheimers disease (AD) genetic risk factor, functional single nucleotide polymorphisms (SNPs) in brain apoE receptors represent excellent candidates for association with AD. Therefore, three low density lipoprotein receptor (LDLR) SNPs were evaluated by TaqMan allelic discrimination assays for association with AD and I found that certain haplotypes alter the odds of AD. A SNP within LDLR exon 12, rs688, was identified in silico as neutralizing a putative exon splicing enhancer (ESE). Since LDLR is a major apoE receptor in the brain, I hypothesized that rs688 modulates LDLR splicing in neural tissues and associates …

Kentucky Women Teachers' Education And Career Choice Decisions: An Application Of Social Cognitive Career Theory, Amanda Brooke Montgomery

University of Kentucky Master's Theses

Career opportunities for women were limited until the 1970s. Teaching is a profession women have long pursued. The purpose of the study was to determine if differences exist in Kentucky women teachers’ demographic characteristics and career choice outcomes by age cohort/era. The population consisted of women who lived in the state of Kentucky and the teacher sample consisted of 110 females, ranging in age from 25-74.

Findings from this study were examined through the Social Cognitive Career Theory’s (SCCT) three constructs: self-efficacy, outcome expectations, and personal goals. Five key influences were reviewed from literature: age, resources, educational attainment, teaching responsibilities, …

The Culture Connection: Testing A Model Of African American Attitudes Toward Mental Health Service Utilization, Andrea Michelle Smith

University of Kentucky Doctoral Dissertations

The purpose of the current study was to combine the factors previously determined to be related to African American help seeking into a single path model and, using structural equation modeling (SEM), determine the relative influence of each factor in the attitudes toward seeking mental health services (see Figure 2.2) among a community sample of African American adults from several metropolitan areas in the US. As such, SEM was utilized to compare the relative fit of two opposing models within this sample, one where a path from economic barriers to help-seeking attitudes was estimated freely and one where that path …