Digital Commons Network^™

Point-Of-Care Ultrasound Used To Exclude Penile Fracture, Adam Ash, Joel Miller, David Preston

Surgery Faculty Publications

This is a case report of a superficial penile hematoma that was difficult to distinguish clinically from a penile fracture. Such cases occur with relative frequency, and because definitive treatment is an urgent surgery, timely diagnosis is essential to avoid complications. Typical imaging modalities such as cavernosonography and magnetic resonance imaging can be invasive (cavernosonography) or time consuming (magnetic resonance imaging) and may not be readily available. Ultrasound has been used successfully in such cases, and, in this case, we used point-of-care ultrasound combined with a brief period of observation to exclude penile fracture.

Editorial Comment: Keeneland Conference Plenary Sessions: Thomas R. Frieden, Julia Costich

Frontiers in Public Health Services and Systems Research

No abstract provided.

Keeneland Conference Plenary Sessions: Thomas R. Frieden, Thomas R. Frieden

Frontiers in Public Health Services and Systems Research

One of the leading challenges in public health today is moving forward as one whether we are part of academia, a clinical health setting, or a public health department, in order to improve health outcomes. Right now in the United States, the leading causes of death are caused from diseases that are preventable. We also face a steady rise in health inequalities among those citizens with a lower socioeconomic status. Director of the CDC, Thomas Friedan addressed the Keeneland conference audience on the impact that public health initiatives have had on the health of our nation. Public health interventions have …

Editorial Comment: Keeneland Conference Plenary Sessions: Richard J. Umbdenstock, Part 2, Glen Mays

Frontiers in Public Health Services and Systems Research

No abstract provided.

Editorial Comment: Keeneland Conference Plenary Sessions: Richard J. Umbdenstock, Part 1, Glen Mays

Frontiers in Public Health Services and Systems Research

No abstract provided.

Keeneland Conference Plenary Sessions: Richard J. Umbdenstock, Richard J. Umbdenstock

Frontiers in Public Health Services and Systems Research

Historically individual and community health problems fed off one another, nonetheless the connection eventually became clear and individual health and population health solutions started to emerge and built off one another. Somewhere along the line, population health and patient health seemed to become divided by a brighter line into 2 separate realms, few of us crossing from one to the otherToday we are looking out for the good of our respective communities. As hospitals move from volume-based payments to value-based payments, they are more concerned about the connection between population health and their own efforts to improve outcomes, care coordination …

Editorial Comment: Keeneland Conference Plenary Sessions: Carol Moehrle, F. Douglas Scutchfield

Frontiers in Public Health Services and Systems Research

No abstract provided.

Keeneland Conferene Plenary Sessions: Carol Moehrle, Carol Moehrle

Frontiers in Public Health Services and Systems Research

Public health accreditation is the measurement of health department performance against a set of standards that are nationally recognized. The Public Health Accreditation Board (PHAB) is a non-profit, voluntary accreditation organization founded in 2007 with the goal to advance public health practice by providing a national framework of accreditation standards for local, state, territorial, and tribal health departments. Public health accreditation has been a methodical, planned transformation of public health. There are huge benefits to accreditation individually and collectively as a system. One of them is reaching the standard of excellence that we now have established in this national voluntary …

Editorial Comment: Keeneland Conference Plenary Sessions: Harvey V. Fineberg, Glen Mays

Frontiers in Public Health Services and Systems Research

No abstract provided.

Keeneland Conference Plenary Sessions: Harvey V. Fineberg, Harvey V. Fineberg

Frontiers in Public Health Services and Systems Research

Healthy communities are essential for healthy individuals. Healthy communities can only exist when preventive measures are taken. When prevention programs are implemented, negative health outcomes can be avoided before they even start. A necessary part of these successful prevention methods requires great research and evidence based practice. Dr. Harvey Fineberg, president of the Institute of Medicine and keynote speaker at the Keeneland Conference, addressed the audience on why good science is imperative to the public health community. It cannot just left up to chance on whether an intervention will work or not; rather it needs to be thoroughly reasoned, grounded …

Editorial Comment: The Makings Of An Evidence-Based Local Health Department: Identifying Administrative And Management Practices, Christopher M. Maylahn

Frontiers in Public Health Services and Systems Research

No abstract provided.

The Makings Of An Evidence-Based Local Health Department: Identifying Administrative And Management Practices, Peg Allen, Ross C. Brownson, Kathleen Duggan, Katherine A. Stamatakis, Paul C. Erwin

Frontiers in Public Health Services and Systems Research

There is a gap in knowledge about how to best organize and administer practice in local health departments to implement sustained evidence-based policies, programs, and interventions. This report identifies administrative and management evidence-based practices to inform ongoing initiatives in local public health system quality improvement, accreditation processes, and performance. The article presents administrative elements in workforce development, leadership, organizational climate and culture, relationships and partnerships, and financial processes that local health departments can address at modest cost within a few years or less. Local public health systems can further identify, implement and evaluate evidence-based administrative practices.

Narrowing The Know-Do Gap In Public Health, Glen Mays

Frontiers in Public Health Services and Systems Research

Like other components of the American health system, public health all too often fails to deploy the strategies that research and experience have shown to be effective in improving population health. These failures, collectively known as the “know-do” gap, occur for many reasons.

The Optimal Calibration Hypothesis: How Life History Modulates The Brain's Social Pain Network, David S. Chester, Richard S. Pond Jr., Stephanie B. Richman, C. Nathan Dewall

Psychology Faculty Publications

A growing body of work demonstrates that the brain responds similarly to physical and social injury. Both experiences are associated with activity in the dorsal anterior cingulate cortex (dACC) and anterior insula. This dual functionality of the dACC and anterior insula underscores the evolutionary importance of maintaining interpersonal bonds. Despite the weight that evolution has placed on social injury, the pain response to social rejection varies substantially across individuals. For example, work from our lab demonstrated that the brain's social pain response is moderated by attachment style: anxious-attachment was associated with greater intensity and avoidant-attachment was associated with less intensity …

Hippocampal Ca1 Transcriptional Profile Of Sleep Deprivation: Relation To Aging And Stress, Nada M. Porter, Julia H. Bohannon, Meredith Curran-Rauhut, Heather M. Buechel, Amy L.S. Dowling, Lawrence D. Brewer, Jelena Popovic, Veronique Thibault, Susan D. Kraner, Kuey-Chu Chen, Eric M. Blalock

Pharmacology and Nutritional Sciences Faculty Publications

BACKGROUND: Many aging changes seem similar to those elicited by sleep-deprivation and psychosocial stress. Further, sleep architecture changes with age suggest an age-related loss of sleep. Here, we hypothesized that sleep deprivation in young subjects would elicit both stress and aging-like transcriptional responses.

METHODOLOGY/PRINCIPAL FINDINGS: F344 rats were divided into control and sleep deprivation groups. Body weight, adrenal weight, corticosterone level and hippocampal CA1 transcriptional profiles were measured. A second group of animals was exposed to novel environment stress (NES), and their hippocampal transcriptional profiles measured. A third cohort exposed to control or SD was used to validate transcriptional results …

Forage News [2012-07], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Drought and Forages
• Kentucky Hay Grower Wins National Hay Awards
• KFGC Field Day to be in Hart County
• Native Warm-Season Grasses In-Service Training
• AFGC National Tour
• If Baling Hay Wet, Watch for Fires
• Custom Grazing of Stocker Cattle
• AFGC 2013 Annual Conference
• AFGC 2013 National Competitions
• Reducing Energy Use in Production Agriculture
• Ohio State Alfalfa Enterprise Budgets Online
• The Diverse Structure and Organization of U.S. Beef Cow-Calf Farms

Global Kentucky (Summer 2012), University Of Kentucky International Center

Global Kentucky

No abstract provided.

Southeastern Law Librarian Summer 2012, Seaall

Newsletters

No abstract provided.

2012 Kentucky Healthcare Market Report, Alison Davis

Community and Economic Development Initiative of Kentucky Reports

No abstract provided.

Social Network Dynamics And Biographical Disruption: The Case Of “First-Timers” With Mental Illness, Brea Perry, Bernice A. Pescosolido

Sociology Faculty Publications

This study examines how dynamics surrounding biographical disruptions compare to more routine fluctuations in personal social networks. Using data from the Indianapolis Network Mental Health Study, the authors track changes in patients’ social networks over three years and compare them to a representative sample of persons with no self-reported mental illness. Overall, individuals at the onset of treatment report larger and more broadly functional social networks than individuals in the population at large. However, the number of network ties among the latter increases over time, whereas network size decreases slightly among people using mental health services. As individuals progress through …

Noninvasive Optical Quantification Of Absolute Blood Flow, Blood Oxygenation, And Oxygen Consumption Rate In Exercising Skeletal Muscle, Katelyn Gurley, Yu Shang, Guoqiang Yu

Biomedical Engineering Faculty Publications

This study investigates a method using novel hybrid diffuse optical spectroscopies [near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS)] to obtain continuous, noninvasive measurement of absolute blood flow (BF), blood oxygenation, and oxygen consumption rate (V̇O₂) in exercising skeletal muscle. Healthy subjects (n=9) performed a handgrip exercise to increase BF and V̇O₂ in forearm flexor muscles, while a hybrid optical probe on the skin surface directly monitored oxy-, deoxy-, and total hemoglobin concentrations ([HbO₂], [Hb], and THC), tissue oxygen saturation (S_tO₂), relative BF (rBF), and relative oxygen …

Toward A Situational Model For Regulating International Crimes, Andrew K. Woods

Law Faculty Scholarly Articles

The international criminal regime, as currently conceived, relies almost exclusively on the power of backward-looking criminal sanctions to deter future international crimes. This model reflects the dominant mid-century approach to crime control, which was essentially reactive. Since then, domestic criminal scholars and practitioners have developed and implemented new theories of crime control—theories notable for their promise of crime prevention through ex ante attention to community and environmental factors. Community policing crime prevention through environmental design, and related "situational" approaches to crime control have had a significant impact on the administration of domestic criminal law.

This Article evaluates the implications of …

Emmet F. Horine And Transylvania’S Special Collections, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

No abstract provided.

Towards Omni-Tomography -- Grand Fusion Of Multiple Modalities For Simultaneous Interior Tomography, Ge Wang, Jie Zhang, Hao Gao, Victor Weir, Hengyong Yu, Wenxiang Cong, Xiaochen Xu, Haiou Shen, James Bennett, Mark Furth, Yue Wang, Michael Vannier

Radiology Faculty Publications

We recently elevated interior tomography from its origin in computed tomography (CT) to a general tomographic principle, and proved its validity for other tomographic modalities including SPECT, MRI, and others. Here we propose "omni-tomography", a novel concept for the grand fusion of multiple tomographic modalities for simultaneous data acquisition in a region of interest (ROI). Omni-tomography can be instrumental when physiological processes under investigation are multi-dimensional, multi-scale, multi-temporal and multi-parametric. Both preclinical and clinical studies now depend on in vivo tomography, often requiring separate evaluations by different imaging modalities. Over the past decade, two approaches have been used for multimodality …

Lipopolysaccharide Impairs Amyloid Β Efflux From Brain: Altered Vascular Sequestration, Cerebrospinal Fluid Reabsorption, Peripheral Clearance And Transporter Function At The Blood-Brain Barrier, Michelle A. Erickson, Pehr E. Hartvigson, Yoichi Morofuji, Joshua B. Owen, D. Allan Butterfield, William A. Banks

Chemistry Faculty Publications

BACKGROUND: Defects in the low density lipoprotein receptor-related protein-1 (LRP-1) and p-glycoprotein (Pgp) clearance of amyloid beta (Aβ) from brain are thought to contribute to Alzheimer's disease (AD). We have recently shown that induction of systemic inflammation by lipopolysaccharide (LPS) results in impaired efflux of Aβ from the brain. The same treatment also impairs Pgp function. Here, our aim is to determine which physiological routes of Aβ clearance are affected following systemic inflammation, including those relying on LRP-1 and Pgp function at the blood-brain barrier.

METHODS: CD-1 mice aged between 6 and 8 weeks were treated with 3 intraperitoneal injections …

Localization And Functional Characterization Of The Rat Oatp4c1 Transporter In An In Vitro Cell System And Rat Tissues, Kuei-Ling Kuo, Haining Zhu, Patrick J. Mcnamara, Markos Leggas

Pharmaceutical Sciences Faculty Publications

The organic anion transporting polypeptide 4c1 (Oatp4c1) was previously identified as a novel uptake transporter predominantly expressed at the basolateral membrane in the rat kidney proximal tubules. Its functional role was suggested to be a vectorial transport partner of an apically-expressed efflux transporter for the efficient translocation of physiological substrates into urine, some of which were suggested to be uremic toxins. However, our in vitro studies with MDCKII cells showed that upon transfection rat Oatp4c1 polarizes to the apical membrane. In this report, we validated the trafficking and function of Oatp4c1 in polarized cell systems as well as its subcellular …

Quantifying The Value Of Public Health Investments, Glen P. Mays

Health Management and Policy Presentations

This session reviews recent findings from a series of studies that estimate the health and economic effects attributable to investments in public health services and delivery systems.

Mice Deficient In Gem Gtpase Show Abnormal Glucose Homeostasis Due To Defects In Beta-Cell Calcium Handling, Jenny E. Gunton, Mary Sisavanh, Rebecca A. Stokes, Jon Satin, Leslie S. Satin, Min Zhang, Sue M. Liu, Weikang Cai, Kim Cheng, Gregory J. Cooney, D. Ross Laybutt, Trina So, Juan-Carlos Molero, Shane T. Grey, Douglas A. Andres, Michael S. Rolph, Charles R. Mackay

Physiology Faculty Publications

AIMS AND HYPOTHESIS: Glucose-stimulated insulin secretion from beta-cells is a tightly regulated process that requires calcium flux to trigger exocytosis of insulin-containing vesicles. Regulation of calcium handling in beta-cells remains incompletely understood. Gem, a member of the RGK (Rad/Gem/Kir) family regulates calcium channel handling in other cell types, and Gem over-expression inhibits insulin release in insulin-secreting Min6 cells. The aim of this study was to explore the role of Gem in insulin secretion. We hypothesised that Gem may regulate insulin secretion and thus affect glucose tolerance in vivo.

METHODS: Gem-deficient mice were generated and their metabolic phenotype characterised by in …

Developing Service Delivery Measures For Studies Of Practice Variation: The Mprove Study, Glen P. Mays

Health Management and Policy Presentations

OBJECTIVES: A growing body of evidence indicates that the delivery of public health activities varies widely across states and communities, creating missed opportunities for prevention as well as inequities in health protection. Consequently, HHS recently used a consensus-based process to develop a framework for improving quality in public health and to identify a set of nine priority areas for improvement. As next steps in operationalizing this framework, measures of quality in public health are needed to guide public health improvement initiatives and to support research on the comparative effectiveness of alternative public health strategies. This presentation profiles the methodology developed …

Roadside Responder Is Struck By A Box Truck And Dies, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On a winter day, a 53-year-old retired fire chief was working for an environmental company to clean up a tractor trailer crash along an interstate. A semi tractor-trailer driver had fallen asleep and crashed. The environmental company had been deployed to assist in the cleanup and facilitate a lane closure. The cleanup was almost complete and there were five workers left at the incident site. They were working in the right lane loading a tag-along trailer with items from the crash when a box truck crashed into the work zone, striking the worker, and killing him.

To prevent future occurrences …