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"Beef: The Real Health Food", Peter Ballerstedt

Forage Symposium at the Kentucky Cattlemen’s Convention

The 2010 Dietary Guidelines for Americans recommends restricting our intake of saturated fat to less than 7 percent of calories, and our cholesterol intake to less than 300 mg per day (less than two eggs). They promote the use of low-fat milk and lean meat, and the use of “meat substitutes” in school lunches. These recommendations are consistent with the official dietary policy that began in 1977 with the release of the first Dietary Goals for the United States by the United States Senate Select Committee on Nutrition and Human Needs. These guidelines were not justified by the then-available science. …

Forages: Change-Challenges-Opportunities, Garry D. Lacefield

Forage Symposium at the Kentucky Cattlemen’s Convention

No abstract provided.

Foreword [2013], Garry D. Lacefield, Christi L. Forsythe

Forage Symposium at the Kentucky Cattlemen’s Convention

No abstract provided.

Public Health Expenditures, Public Health Delivery Systems, And Population Health, Glen P. Mays

Health Management and Policy Presentations

This seminar examines a series of approaches for estimating the health and economic effects attributable to public health expenditures in the U.S., along with a novel method for estimating economies of scale and scope in the delivery of public health services. The use of instrumental-variables techniques and network analytic methods are described in these research approaches.

Assembly Of The Type Ii Secretion System Such As Found In Vibrio Cholerae Depends On The Novel Pilotin Asps, Rhys A. Dunstan, Eva Heinz, Lakshmi C. Wijeyewickrema, Robert N. Pike, Anthony W. Purcell, Timothy J. Evans, Judyta Praszkier, Roy M. Robins-Browne, Richard A. Strugnell, Konstantin V. Korotkov, Trevor Lithgow

Molecular and Cellular Biochemistry Faculty Publications

The Type II Secretion System (T2SS) is a molecular machine that drives the secretion of fully-folded protein substrates across the bacterial outer membrane. A key element in the machinery is the secretin: an integral, multimeric outer membrane protein that forms the secretion pore. We show that three distinct forms of T2SSs can be distinguished based on the sequence characteristics of their secretin pores. Detailed comparative analysis of two of these, the Klebsiella-type and Vibrio-type, showed them to be further distinguished by the pilotin that mediates their transport and assembly into the outer membrane. We have determined the crystal structure of …

Lifelong Bilingualism Maintains Neural Efficiency For Cognitive Control In Aging, Brian T. Gold, Chobok Kim, Nathan F. Johnson, Richard J. Kryscio, Charles D. Smith

Neuroscience Faculty Publications

Recent behavioral data have shown that lifelong bilingualism can maintain youthful cognitive control abilities in aging. Here, we provide the first direct evidence of a neural basis for the bilingual cognitive control boost in aging. Two experiments were conducted, using a perceptual task-switching paradigm, including a total of 110 participants. In Experiment 1, older adult bilinguals showed better perceptual switching performance than their monolingual peers. In Experiment 2, younger and older adult monolinguals and bilinguals completed the same perceptual task-switching experiment while functional magnetic resonance imaging (fMRI) was performed. Typical age-related performance reductions and fMRI activation increases were observed. However, …

Risk Score Modeling Of Multiple Gene To Gene Interactions Using Aggregated-Multifactor Dimensionality Reduction, Hongying Dai, Richard J. Charnigo, Mara L. Becker, J. Steven Leeder, Alison A. Motsinger-Reif

Statistics Faculty Publications

BACKGROUND: Multifactor Dimensionality Reduction (MDR) has been widely applied to detect gene-gene (GxG) interactions associated with complex diseases. Existing MDR methods summarize disease risk by a dichotomous predisposing model (high-risk/low-risk) from one optimal GxG interaction, which does not take the accumulated effects from multiple GxG interactions into account.

RESULTS: We propose an Aggregated-Multifactor Dimensionality Reduction (A-MDR) method that exhaustively searches for and detects significant GxG interactions to generate an epistasis enriched gene network. An aggregated epistasis enriched risk score, which takes into account multiple GxG interactions simultaneously, replaces the dichotomous predisposing risk variable and provides higher resolution in the quantification …

A Neural Network Model To Translate Brain Developmental Events Across Mammalian Species, Radhakrishnan Nagarajan, Jeffrey N. Jonkman

Biostatistics Faculty Publications

Translating the timing of brain developmental events across mammalian species using suitable models has provided unprecedented insights into neural development and evolution. More importantly, these models can prove to be useful abstractions and predict unknown events across species from known empirical event timing data retrieved from published literature. Such predictions can be especially useful since the distribution of the event timing data is skewed with a majority of events documented only across a few selected species. The present study investigates the choice of single hidden layer feed-forward neural networks (FFNN) for predicting the unknown events from the empirical data. A …

Gleevec, An Abl Family Inhibitor, Produces A Profound Change In Cell Shape And Migration, Zaozao Chen, Elizabeth Lessey, Matthew E. Berginski, Li Cao, Jonathan Li, Xavier Trepat, Michelle Itano, Shawn M. Gomez, Maryna Kapustina, Cai Huang, Keith Burridge, George Truskey, Ken Jacobson

Markey Cancer Center Faculty Publications

The issue of how contractility and adhesion are related to cell shape and migration pattern remains largely unresolved. In this paper we report that Gleevec (Imatinib), an Abl family kinase inhibitor, produces a profound change in the shape and migration of rat bladder tumor cells (NBTII) plated on collagen-coated substrates. Cells treated with Gleevec adopt a highly spread D-shape and migrate more rapidly with greater persistence. Accompanying this more spread state is an increase in integrin-mediated adhesion coupled with increases in the size and number of discrete adhesions. In addition, both total internal reflection fluorescence microscopy (TIRFM) and interference reflection …

Snap And Obesity, Craig Gundersen

University of Kentucky Center for Poverty Research Discussion Paper Series

No abstract.

Predictors Of The Change In The Expression Of Emotional Support Within An Online Breast Cancer Support Group: A Longitudinal Study, Woohyun Yoo, Ming-Yuan Chih, Min-Woo Kwon, Junghwan Yang, Eunji Cho, Bryan Mclaughlin, Kang Namkoong, Dhavan V. Shah, David H. Gustafson

Community & Leadership Development Faculty Publications

OBJECTIVES: To explore how the expression of emotional support in an online breast cancer support group changes over time, and what factors predict this pattern of change.

METHODS: We conducted growth curve modeling with data collected from 192 participants in an online breast cancer support group within the Comprehensive Health Enhancement Support System (CHESS) during a 24-week intervention period.

RESULTS: Individual expression of emotional support tends to increase over time for the first 12 weeks of the intervention, but then decrease slightly with time after that. In addition, we found that age, living situation, comfort level with computer and the …

Valuation Of Recreational Beach Quality And Water Quality Management Strategies In Oahu, Jerrod M. Penn

Theses and Dissertations--Agricultural Economics

Hawaii’s pristine ocean and tropical environment is a keystone of Hawaii tourism and the state economy. Water pollution from stormwater and development threatens the beach quality to both residents and tourists. In order to understand the lost nonmarket value, we assess changes in quality of beach characteristics including water and sand quality, swimming safety conditions, and congestion using a Discrete Choice Experiment of recreational beach users. Further, we study willingness to pay (WTP) for water management strategies in Hawaii using another discrete choice experiment, including structural and nonstructural Best Management Practices, testing, monitoring, and educational efforts.

Using a mixed logit …

Monitoring Dairy Cow Feed Intake Using Machine Vision, Anthony N. Shelley

Theses and Dissertations--Electrical and Computer Engineering

The health and productive output of dairy cows can be closely correlated to individual cow feed intake. Being able to monitor feed intake on a daily basis is beneficial dairy farm management. Each cow can be addressed individually with minimal time required from those working with the animals. This is essential as time management is closely tied to resource management in a dairy operation. Anything that can save time and resources and increase profitability and herd health is a paramount advantage in dairy farming. This study examined the use of machine vision structured light illumination three-dimensional scanning of cow feed …

The Clean Air Act: The End Of A Chevron Era?, Erin Murphy

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Table Of Contents For Volume 6, Issue 1, Kentucky Journal Of Equine, Agriculture, & Natural Resources Law

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

What To Do With America's Nuclear Defense Waste: The Hanford Effect, Joseph A. Cohen

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

From Shanghai To Huangbaiyu: Eco-Cities As An Alternative Modernity, Jared Flanery

Gaines Fellow Senior Theses

No abstract provided.

Thoroughbred Farm Managers' Willingness-To-Pay For Alternative Deworming Regimens In Horses, Marion Angélique Robert

Theses and Dissertations--Agricultural Economics

Parasite control is important to horse health and horse owners should feel highly concerned about the proper treatment of parasites. In the past 30 years, veterinary science has made important advances in treating parasites and provided new products and strategies to optimize treatment and prevention. However, horse owners and managers have been slow to adopt these new recommendations.

This study investigates why the transition has not occurred as expected. It examines issues related to the decision-making process of horse owners and managers as they relate to deworming strategies. In addition, it investigates current deworming approaches as well as attitudes towards …

Low-Income Adults Food Management Practices And Nutrition Behaviors And The Association With Diet, Sarah Elizabeth Lewis

Theses and Dissertations--Nutrition and Food Systems

Food insecurity and diet quality are concerns in low-income populations, contributing to high rates of obesity. Food management skills may enable low-income populations to obtain a healthy food supply rather than relying on less expensive and less nutritious foods to fill their diets. The purpose of this study was to assess the relationship between food management practices and diet quality in SNAP-ED/EFNEP participants. This study examines the association between food management behaviors and dietary outcomes (Healthy Eating Index totals, total calories, carbohydrates, protein, fat, and fiber, and servings of fruits, vegetables, milk, and meats/beans) as measured by the Behavior Checklist …

The Role Of Macrophages In Exercise And Insulin Resistance In Human Skeletal Muscle, Jason S. Groshong

Theses and Dissertations--Physiology

Muscle biopsies were taken at baseline, post eccentric exercise, post aerobic training, and after training followed by eccentric exercise from adults with different health status. In Cell Western analysis of pAkt/Akt ratio suggests that muscle cells isolated from baseline biopsies respond to insulin in a dose dependent manner that tracks with sensitivity to insulin of the host; however, this is uncoupled from glucose disposal in vitro. Nitrotyrosine (NY), a marker of free radical damage, was employed to assess the efficacy of the exercise paradigm. NY immunohistochemistry on muscle cross-sections revealed that eccentric exercise significantly increased damage in older ( …

Latexin’S Role In Regulating Hematopoietic Stem And Progenitor Cells, Yi Liu

Theses and Dissertations--Physiology

Previous studies in our lab identified a novel gene, latexin (Lxn), that regulates murine hematopoietic stem cells through balancing apoptosis, self-renewal and proliferation. In these dissertation studies, I performed a series of experiments to examine the function of Lxn using a Lxn conventional knockout mouse, and characterize Lxn’s role in the presence of hematopoietic stresses such as ionizing radiation, cytokines induced-mobilization, and hematopoietic malignancy.

The first series of experiments was designed to determine the role of Lxn in hematopoiesis under homeostatic conditions. I found that Lxn-/- mice exhibited hyperproliferative hematopoiesis, a repopulation advantage and elevated self-renewal capacity …

Preclinical Development Of Phytocannabinoid- And Endocannabinoid- Based Pharmacotherapies For The Treatment Of Ethanol-Induced Neurodegeneration, Daniel J. Liput

Theses and Dissertations--Pharmacy

Excessive ethanol consumption, characteristic of alcohol use disorders (AUDs), is associated with widespread neurodegeneration and cognitive and behavioral impairments that may contribute to the chronic and relapsing nature of alcoholism. Therefore, identifying novel targets that can afford neuroprotection will undoubtedly aid current treatment strategies for AUDs. The cannabinoids have been shown to provide neuroprotection in a variety of preclinical models of neurodegeneration; however minimal data is available regarding the use of cannabinoid-based pharmacotherapies for treating ethanol-induced neurodegeneration. Therefore, the current dissertation examined the overarching hypothesis: the cannabinoids are a therapeutic strategy to afford neuroprotection in the context of ethanol-induced neurodegeneration. …

Effects Of Family Structure On Educational Attainment And Health Insurance Coverage Of Youth In The Lower Mississippi Delta Region, Chaquenta L. Smith

Theses and Dissertations--Agricultural Economics

A large body of research, typically nationally focused, has examined the relationship between family structure, educational attainment, and healthcare access. Within this field of study, there is limited availability of regionally based studies, specifically the Lower Mississippi Delta (LMD) region. This exploratory study examines the effects of family structure on high school graduation rates and health insurance coverage within the LMD region. The objective is to determine if family structure has a direct impact on the educational attainment and health outcomes of a child within the region using concepts from nationally focused literature. Through the use of an OLS regression, …

Predicting Students’ Confidence: How Teacher Feedback And Other Sources Influence Self-Efficacy In Mathematics Classrooms, Megan Kleine-Kracht Thomas

Theses and Dissertations--Educational, School, and Counseling Psychology

In this two-part dissertation, the sources of self-efficacy were investigated for elementary and middle school students in mathematics classrooms. In the first study, the Sources of Middle School Mathematics Scale (Usher & Pajares, 2009) was validated with a younger sample. Participants included 367 fourth- through sixth-grade students; these participants completed two surveys investigating their beliefs regarding their capabilities to perform successfully in mathematics. This study included an examination of the psychometric properties and a confirmatory factor analysis of the Sources of Middle School Mathematics Self-Efficacy Scale, and an investigation into the relative power of mastery experience, vicarious experience, social persuasions, …

An Examination Of Education Services For Children With Autism Spectrum Disorders In Rural Areas, Melissa A. Murphy

Theses and Dissertations--Educational, School, and Counseling Psychology

Much research and media attention in recent years has focused on Autism Spectrum Disorders (ASD), a pervasive developmental disorder that impacts children in multiple areas of their lives. Early identification and intervention, as well as access to mental health, behavioral, and pediatric services for this population are crucial to their later outcomes and quality of life (American Academy of Pediatrics, 2001; Blane & Borden, 2008; Jacobson & Mulick, 2000; Rogers & Vismara, 2008). Unfortunately, research suggests that access to educational services may be complicated for individuals living in rural areas (Applequist, 2009; Collins et al., 2005, Ludlow, Conner, & Schechter …

Evaluating The Efficacy Of Client Feedback In Group Psychotherapy, Norah C. Slone

Theses and Dissertations--Educational, School, and Counseling Psychology

A review of the adult psychotherapy outcome literature reveals decades of empirical studies that support the efficacy of group treatment for mental health concerns (Burlingame, Fuhriman, & Mosier, 2003; Horne & Rosenthal, 1997). Although research demonstrates positive results for the utilization of group therapy, between 33-50% of clients drop out before treatment is completed (Baekeland & Lundwall, 1975; Wierzbicki & Pekarik, 1993). Methods for improving psychotherapy retention have been addressed through the application of a client feedback model (i.e., monitoring treatment outcome routinely). Although using client feedback has been found to be beneficial for improving retention and even enhancing client …

Convergent Validity Of The Functional Assessment Informant Record For Teachers (Fair-T), Laura E. Pierce

Theses and Dissertations--Educational, School, and Counseling Psychology

This study assessed the convergent validity of the Functional Assessment Informant Record for Teachers (FAIR-T; Edwards, 2002) with analog functional analyses (FAs). Participants were five teachers and students located at a specialized school serving individuals with disabilities. Teachers had worked with the student for a minimum of 1 month, and students displayed a variety of behavioral topographies. The FAIR-T was conducted by the researcher using telephone or video conferencing technology, and analog functional analyses were conducted in a clinic setting by trained therapists within the course of the student’s typical treatment plan. Results of the FAIR-T were coded according to …

The Cultural Discontinuity Hypothesis: An Appalachian American Perspective In Eastern Kentucky, Timothy W. Conner Ii

Theses and Dissertations--Educational, School, and Counseling Psychology

K.M. Tyler et al. (2008) propose a quantitative method to measure differences between school and home experiences had by students of ethnic minority status and how such differences (cultural discontinuity) may affect psychological factors related to student achievement. Although study of cultural discontinuity has been applied to understanding African American, Asian American, Latino American, and Native American student populations, little attention has been given to the ways in which cultural discontinuity may manifest in the Appalachian American population. This study conceptualizes the socio-cultural conditions that would warrant such an investigation, establishing evidence from ten interview subjects of the presence of …

Reading Self-Efficacy In Early Adolescence: Which Measure Works Best?, Raven Richardson Piercey

Theses and Dissertations--Educational, School, and Counseling Psychology

The purpose of this dissertation is to investigate the relationship between self-efficacy and reading achievement and to examine the predictive validity of a variety of reading self-efficacy measures in a sample of 364 students in Grades 4 to 6. Mean differences in self-efficacy were also examined by gender, ethnicity, and school type. Results suggested that the four measures of reading self-efficacy were psychometrically sound. Mean differences were not present for students based on gender or ethnicity. Elementary school students reported higher levels of reading test self-efficacy than did middle school students. Reading self-efficacy predicted reading performance as measured by four …

The Impact Of Racial Identity, Masculinity, And Academic Self-Concept On The Academic Achievement Of African American Male High School Students, Howard Lloyd

Theses and Dissertations--Educational, School, and Counseling Psychology

Previous literature has evidenced that young African American males are experiencing less academic success than their Caucasian male and African American female counterparts (Davis, Williams, & Williams, 2004; Flores, 2007). The deceleration of achievement in this population has spawned some inquiry into the struggles of African American students. However, investigators have primarily examined differences in sex, school attributes, socioeconomic status, family structure, and other external factors. Previous research has also highlighted the unique obstacles young African American men face in education settings. While researchers have identified several external predictors of academic achievement among African American males, scant information relates to …