Digital Commons Network^™

Corporate Voluntarism And Liability For Human Rights In A Post-Kiobel World, Robert C. Bird, Daniel R. Cahoy, Lucien J. Dhooge

Kentucky Law Journal

No abstract provided.

Pretrial Detention In Kentucky: An Analysis Of The Impact Of House Bill 463 During The First Two Years Of Its Implementation, Robert Veldman

Kentucky Law Journal

No abstract provided.

Ipos And The Slow Death Of Section 5, Donald C. Langevoort, Robert B. Thompson

Kentucky Law Journal

No abstract provided.

4% Absent = 100% Disaster: Why The Math Doesn't Add Up On Fixed Attendance Leave Policies Under The Fmla, Laraclay Parker

Kentucky Law Journal

No abstract provided.

The Kentucky Religious Freedom Act: Neither A Savior For The Free Exercise Of Religion Nor A Monstrous Threat To Civil Rights, Jennifer A. Pekman

Kentucky Law Journal

No abstract provided.

The Ffoci, And Other Measures And Models Of Ocpd, Cristina M. Pinsker

Theses and Dissertations--Psychology

The Five Factor Obsessive Compulsive Inventory (FFOCI) was developed in part to facilitate a shift from the categorical classification of personality disorder to a dimensional model; more specifically, the five-factor model. Questions though have been raised as to whether obsessive-compulsive personality disorder can be understood as a maladaptive variant of FFM conscientiousness. The purpose of the present study was to provide a further validation of the FFOCI, as well as to compare and contrast alternative measures and models of OCPD. A total of 380 participants, including 146 oversampled for OCPD traits, were recruited from introductory psychology courses at the University …

Self-Regulation In Older Adults: The Prioritization Of Emotion Regulation, Daniel R. Evans

Theses and Dissertations--Psychology

Despite having fewer cognitive resources, older adults regulate their emotions as well as, if not better than, younger adults. This study aimed to (1) test the limits of older adults’ emotion regulation capacity and (2) gain a better understanding of how older adults use their more limited resources to regulate their emotions. Participants included 48 healthy older adults aged 65-85 from the community and 50 healthy younger adults aged 18-25 from the student population. They were randomly assigned to one of four experimental groups involving an initial activity that was high or low in self-regulatory demand followed by a test …

Contribution Of Nucleus Accumbens Core To Impulsive Choice: Role Of Dopamine And Glutamate Systems, Justin R. Yates

Theses and Dissertations--Psychology

Impulsive choice refers to the inability to delay gratification and is associated with increased drug abuse vulnerability. Understanding the underlying neural mechanisms linking impulsive choice and drug abuse can contribute to improved treatment options for individuals with substance use disorders. Evidence suggests a major role for nucleus accumbens core (NAcc) in impulsive choice and the reinforcing effects of drugs of abuse. The neurotransmitters glutamate (Glu) and dopamine (DA) are implicated in the neural adaptations observed in drug addiction; however, the role of intra-NAcc Glu and DA in impulsive choice is unclear. Rats were trained in a delay discounting task, in …

Examining The Vulnerability Of Inhibitory Control To The Impairing Effects Of Alcohol, Melissa A. Miller

Theses and Dissertations--Psychology

There is growing evidence that acute changes in fundamental mechanisms of impulse control contribute to the transition from social drinking to abusive drinking. One component of impulsivity concerns the ability to inhibit maladaptive behaviors (i.e., inhibitory control). Inhibitory mechanisms are reliably shown to be sensitive to the impairing effects of alcohol, and studies have begun to show that this impairment fails to recover at the same speed as other aspects of behavior. However, the degree to which inhibitory control develops tolerance to alcohol has only been examined under limited conditions. This dissertation consists of three studies examining contexts in which …

Eating Disorder Onset In Young Girls: A Longitudinal Trajectory Analysis, Carolyn M. Pearson

Theses and Dissertations--Psychology

To investigate whether there are different patterns of development for binge eating and purging behavior among pre-adolescent and early adolescent girls, I conducted trajectory analyses of those behaviors in 938 girls across eight waves of data from the spring of 5^th grade (the last year of elementary school) through the spring of 9^th grade (the first year of high school). Analyses revealed four separate developmental trajectories for binge eating behavior (labeled none, increasing, decreasing, and high steady) and three separate developmental trajectories for purging behavior (labeled none, dabble, and increasing). Fifth grade scores on risk factors that were …

Effects Of Coaching In The Detection Of Malingered Attention Deficit/Hyperactivity Disorder In A College Sample, Maryanne Edmundson

Theses and Dissertations--Psychology

College students may feign symptoms of ADHD to gain access to stimulant medications and academic accommodations. Research has shown that it can be difficult to discriminate malingered from genuine symptomatology, especially when evaluations are based only on self-report. The present study investigated whether the average student given no additional information could feign ADHD as successfully as those who were coached on symptoms. Similar to Jasinski, Harp, Berry, Shandera-Ochsner, Mason, & Ranseen (2011) and other research on feigned ADHD, an extensive battery of neuropsychological, symptom validity, and self-report tests was administered. Undergraduates with no history of ADHD or other psychiatric disorders …

Negative Urgency, Pubertal Onset And The Longitudinal Prediction Of Alcohol Consumption During The Transition From Preadolescence To Adolescence, Lauren Helena Boyle

Theses and Dissertations--Psychology

Alcohol use in early adolescence is associated with numerous concurrent and future problems, including diagnosable alcohol use disorders. The trait of negative urgency, the tendency to act rashly when distressed, is an important predictor of alcohol-related dysfunction in youth and adults. The aim of this study was to test a model proposed by Cyders and Smith (2008) specifying a puberty-based developmental increase in negative urgency, which in turn predicts subsequent increases in early adolescent drinking. In a sample of 1,910 youth assessed semi- annually from spring of 5th grade through spring of 8th grade, we found support for this model. …

Diaphragmatic Breathing And Its Effect On Inhibitory Control, Matthew Russell

Theses and Dissertations--Psychology

Evidence suggests that slow paced diaphragmatic breathing (DB) can significantly affect prefrontal cortex functions through increasing an individual’s physiological self-regulatory capacity. The current research demonstrates the effects of paced DB on inhibitory control, which is considered to be a reliable measure of behavioral self-regulation. Eighty healthy participants were randomly assigned to one of two conditions (20 males and females each). Participants were instructed on either DB at a pace of six-breaths per minute (BPM) or instructions on environmental awareness and asked to breathe at 12 BPM. Following training, all participants completed a computer-based task designed to examine inhibitory processes. Physiological …

Acute Effects Of Alcohol On Simulated Driving Performance And Self-Perceptions Of Impairment In Dui Offenders, Nicholas A. Van Dyke

Theses and Dissertations--Psychology

Licensed drivers arrested for driving under the influence (DUI) of alcohol have increased rates of vehicle crashes, moving violations, and traffic tickets (Evans, 2004). To date, no research has examined specific self-regulatory mechanisms of the DUI driver under a dose of alcohol that might underlie risky driving behavior. The present study examined the degree to which DUI drivers display an increased sensitivity to the acute impairing effects of alcohol on driving performance and overestimate their driving fitness following alcohol consumption. Adult drivers with a history of DUI and a demographically-matched group of control drivers without a DUI were tested following …

Reevaluation Of The Aapm Tg-43 Brachytherapy Dosimetry Parameters For An 125I Seed, And The Influence Of Eye Plaque Design On Dose Distributions And Dose-Volume Histograms, Prakash Aryal

Theses and Dissertations--Physics and Astronomy

The TG-43 dosimetry parameters of the Advantage^{TM 125}I model IAI-125A brachytherapy seed were studied. An investigation using modern MCNP radiation transport code with updated cross-section libraries was performed. Twelve different simulation conditions were studied for a single seed by varying the coating thickness, mass density, photon energy spectrum and cross-section library. The dose rate was found to be 6.3% lower at 1 cm in comparison to published results. New TG-43 dosimetry parameters are proposed.

The dose distribution for a brachytherapy eye plaque, model EP917, was investigated, including the effects of collimation from high-Z slots. Dose distributions for …

Examination Of The Potential Association Of Stress With Morbidity And Mortality Outcomes In Patient With Heart Failure, Abdullah S. Alhurani, Rebecca Dekker, Elizabeth Tovar, Alison Bailey, Terry A. Lennie, David C. Randall, Debra K. Moser

Nursing Faculty Publications

OBJECTIVES: The high mortality and morbidity rates associated with heart failure are still not well explained. A few psychosocial factors have been studied and explain some of this risk, but other factors, like stress, remain largely unexplored in heart failure. This study aimed to (1) examine the association of stress with 6-month cardiac event-free survival, (2) examine the relationship of stress with salivary cortisol, and (3) examine the association of salivary cortisol level with 6-month cardiac event-free survival.

METHOD: A total of 81 heart failure patients participated. Stress was measured using the brief Perceived Stress Scale. Cortisol was …

Environmental Enrichment Reduces Methamphetamine Cue-Induced Reinstatement But Does Not Alter Methamphetamine Reward Or Vmat2 Function, Rebecca S. Hofford, Mahesh Darna, Carrie E. Wilmouth, Linda P. Dwoskin, Michael T. Bardo

Psychology Faculty Publications

Environmental factors influence a variety of health-related outcomes. In general, being raised in an environment possessing social, sensory, and motor enrichment reduces the rewarding effects of various drugs, thus protecting against abuse vulnerability. However, in the case of methamphetamine (METH), which acts at the vesicular monoamine transporter 2 (VMAT2) to enhance dopamine release from the cytosol, previous evidence suggests that METH reward may not be altered by environmental enrichment. This study examined the influence of an enriched environment on measures of METH reward, METH seeking, and VMAT2 function. Rats were raised from weaning to adulthood in either an enriched environment …

Effect Of Body Mass Index On Post-Exercise Hemodynamic Responses, Stephanie M. Moore

Theses and Dissertations--Kinesiology and Health Promotion

To assess the relationships of body mass index (BMI) on arterial stiffness at rest and post-maximal treadmill graded exercise testing (GXT).

Forty-four apparently healthy, young adult males (22.1 ± 0.48 years) were recruited and divided into either a healthy weight (H, ≤24.9 kg/m²), overweight (OV, 24.9-29.9 kg/m²) or obese (OB, ≥29.9 kg/m²) group based on BMI. All subjects underwent arterial stiffness (carotid-femoral pulse wave velocity, cfPWV), blood pressure (BP), pulse pressure (PP), mean arterial pressure (MAP) and body composition (bioelectrical impedance analysis, BIA) measurements at rest. Following the GXT, measures of arterial stiffness (cfPWV) …

Factors Influencing Peripheral Skin Temperature Circadian Rhythm In Young Adult Males, Hannah Tranel

Theses and Dissertations--Kinesiology and Health Promotion

Periodic cues, including scheduled exercise, social interactions, sleep habits, and feeding time, have been shown to alter the circadian system. A disruption in circadian rhythms has been shown to have negative effects on health. Frequent skin temperature measures have been shown to be a valid method of assessing circadian rhythm parameters. The purpose of this study was to determine group mean differences in temperature amplitude, stability and lag measures among groups of young men of varying (optimal, fair and poor) adiposities. The strength of the association among the temperatures parameters and measures of body composition, physical fitness and activity, nutritional …

The Effect Of Tactical Tasks And Gear On Muscle Activation Of Swat Officers, Jason M. Keeler

Theses and Dissertations--Kinesiology and Health Promotion

Special Weapons and Tactics (SWAT) officers constitute a subgroup of specialized law enforcement officers that perform a variety of tactical operations while wearing approximately 40 kg of tactical gear. Lower back pain is a prevalent musculoskeletal injury suffered by SWAT officers. Tactical gear places significant stress on the lower back. Thus, it is important to quantify the effect that tactical gear has on muscle activation levels of torso musculature while performing occupational tasks. Electromyography was evaluated on 20 male subjects (age: 34.7±4.5 yr.; height: 1.79±.10 m; body mass: 91.53±17.32 kg; mass of gear: 13.82±1.90 kg) while performing four tactical tasks …

Training Strategies And Movement Assessments In Athletes And Non-Athletes, Matthew David Lewis

Theses and Dissertations--Kinesiology and Health Promotion

This dissertation is composed of three manuscripts based on two studies related to training and assessment methods used to evaluate change and overall quality in measures of performance, postural control, and functional movement. Study one evaluated the effect of sand training on athletic performance and postural control. Study two investigated the effect of scoring strata of the deep squat (DS) component of the Functional Movement Screen (FMS) on the weight-bearing lunge test (WBLT), Star Excursion Balance Test (SEBT), and Lateral Flexion Test (LFT) in 101 male and female college students.

Study one results included significant overall improvements of the five …

Dating Violence On Small Rural College Campuses: Are Administrator And Student Perceptions Similar?, Jean Allen Oldham

Theses and Dissertations--Kinesiology and Health Promotion

In recent years dating violence has become more and more prevalent on college campuses. Reports of the range of dating violence vary widely, with studies reporting from 20% to 85% of college women experiencing dating violence. However, almost all research has been conducted among urban and/or large colleges and universities, with virtually no attention to what is happening on small and/or rural college and university campuses.

When a possible 20% of college women have experienced dating violence on college campuses, there becomes a crucial need for administration at a college to have an accurate assessment of the college’s liability, and …

Forget Me, Forget Me Not: Reconciling Two Different Paradigms Of The Right To Be Forgotten, Lawrence Siry

Kentucky Law Journal

In May of 2014, the Court of Justice of the European Union handed down its decision in the case of Google Spain SL v. Agencia Española de Protección de Datos. This landmark decision ignited a firestorm of debate over the "right to be forgotten": the right of users to withdraw information about themselves available on the internet. With concerns about the restriction of the freedom of expression on the internet, many commentators have criticized the decision as unworkable and dangerous. Others have recognized continuity in the development of privacy and data protection jurisprudence within the European courts. Meanwhile in …

The Right To Be Forgotten: Who Decides What The World Forgets?, Patricia Sánchez Abril, Jacqueline D. Lipton

Kentucky Law Journal

In May 2014, the Court of Justice for the European Union ("CJEU") surprised the global cyber law community by holding that search engines like Google are "controllers" of the processing of personal data under the European Union Data Protection Directive. This means that they are obliged in some circumstances to remove links from search results that pertain to information that infringes on an individual's rights under the Directive. This obligation has come to be referred to as an aspect of a digital "right to be forgotten." The search results in question related to a mortgage sale of property in a …

Obesity Reduces Left Ventricular Strains, Torsion, And Synchrony In Mouse Models: A Cine Displacement Encoding With Stimulated Echoes (Dense) Cardiovascular Magnetic Resonance Study, Sage P. Kramer, David K. Powell, Christopher M. Haggerty, Cassi M. Binkley, Andrea C. Mattingly, Lisa A. Cassis, Frederick H. Epstein, Brandon K. Fornwalt

Pediatrics Faculty Publications

BACKGROUND: Obesity affects a third of adults in the US and results in an increased risk of cardiovascular mortality. While the mechanisms underlying this increased risk are not well understood, animal models of obesity have shown direct effects on the heart such as steatosis and fibrosis, which may affect cardiac function. However, the effect of obesity on cardiac function in animal models is not well-defined. We hypothesized that diet-induced obesity in mice reduces strain, torsion, and synchrony in the left ventricle (LV).

METHODS: Ten 12-week-old C57BL/6 J mice were randomized to a high-fat or low-fat diet. After 5 months on …

The Public Health Pbrn Program: A Summative Report, Center For Public Health Systems And Services Research

UKCPHSSR Research Briefs and Reports

This program seeks to expand the volume and quality of evidence on how best to organize, finance, and deliver public health services by: (1) helping to organize and develop practice-based research networks (PBRNs) comprised of public health agencies and skilled research institutions; (2) selecting grantees to receive funding and technical assistance for PBRN research projects; and (3) facilitating the successful development, implementation, and translation of research projects through PBRNs by providing technical assistance, fostering peer learning, and leading selected multi-network research activities.

Nicotine Exploits A Copi-Mediated Process For Chaperone-Mediated Up-Regulation Of Its Receptors, Brandon J. Henderson, Rahul Srinivasan, Weston A. Nichols, Crystal N. Dilworth, Diana F. Gutierrez, Elisha D. W. Mackey, Sheri Mckinney, Ryan M. Drenan, Christopher I. Richards, Henry A. Lester

Chemistry Faculty Publications

Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinson's disease. nAChRs containing the α6 subunit (α6* nAChRs) are expressed in neurons in several brain regions, but comparatively little is known about the effect of chronic nicotine on these nAChRs. We report here that nicotine up-regulates α6* nAChRs in several mouse brain regions (substantia nigra pars compacta, ventral tegmental area, medial habenula, and superior colliculus) and in neuroblastoma 2a cells. We present evidence that a coat protein complex I (COPI)-mediated process mediates this …

Sphingosine-1-Phosphate-Mediated Mobilization Of Hematopoietic Stem/Progenitor Cells During Intravascular Hemolysis Requires Attenuation Of Sdf-1-Cxcr4 Retention Signaling In Bone Marrow, Kasia Mierzejewska, Yuri M. Klyachkin, Janina Ratajczak, Ahmed Abdel-Latif, Magda Kucia, Mariusz Z. Ratajczak

Saha Cardiovascular Research Center Faculty Publications

Sphingosine-1-phosphate (S1P) is a crucial chemotactic factor in peripheral blood (PB) involved in the mobilization process and egress of hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM). Since S1P is present at high levels in erythrocytes, one might assume that, by increasing the plasma S1P level, the hemolysis of red blood cells would induce mobilization of HSPCs. To test this assumption, we induced hemolysis in mice by employing phenylhydrazine (PHZ). We observed that doubling the S1P level in PB from damaged erythrocytes induced only a marginally increased level of mobilization. However, if mice were exposed to PHZ together with the …

Inflammatory Cytokine Gene Expression In Mesenteric Adipose Tissue During Acute Experimental Colitis, William Conan Mustain, Marlene E. Starr, Joseph Daniel Valentino, Donald A. Cohen, Daiki Okamura, Chi Wang, B. Mark Evers, Hiroshi Saito

Markey Cancer Center Faculty Publications

BACKGROUND: Production of inflammatory cytokines by mesenteric adipose tissue (MAT) has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Animal models of colitis have demonstrated inflammatory changes within MAT, but it is unclear if these changes occur in isolation or as part of a systemic adipose tissue response. It is also unknown what cell types are responsible for cytokine production within MAT. The present study was designed to determine whether cytokine production by MAT during experimental colitis is depot-specific, and also to identify the source of cytokine production within MAT.

METHODS: Experimental colitis was induced in 6-month-old C57BL/6 …

Regulation Of Pten Inhibition By The Pleckstrin Homology Domain Of P-Rex2 During Insulin Signaling And Glucose Homeostasis, Cindy Hodakoski, Benjamin D. Hopkins, Douglas Barrows, Sarah M. Mense, Megan Keniry, Karen E. Anderson, Philip A. Kern, Phillip T. Hawkins, Len R. Stephens, Ramon Parsons

Clinical and Translational Science Faculty Publications

Insulin activation of phosphoinositide 3-kinase (PI3K) signaling regulates glucose homeostasis through the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3). The dual-specificity phosphatase and tensin homolog deleted on chromosome 10 (PTEN) blocks PI3K signaling by dephosphorylating PIP3, and is inhibited through its interaction with phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 (P-REX2). The mechanism of inhibition and its physiological significance are not known. Here, we report that P-REX2 interacts with PTEN via two interfaces. The pleckstrin homology (PH) domain of P-REX2 inhibits PTEN by interacting with the catalytic region of PTEN, and the inositol polyphosphate 4-phosphatase domain of P-REX2 provides high-affinity binding to the postsynaptic …