Digital Commons Network^™

An Exploration Of Empowerment, Sexual Violence, And Hiv Among Indian Women, Brigid Kyung-Hwa Cecil

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Empowerment plays a major role in sexual violence and HIV among women worldwide. Findings on empowerment in relation to domestic violence or HIV are scarce and are conflicting. The purpose of this study was to examine the relationship between empowerment and HIV status by means of sexual violence, and to compare this relationship between previously married women (N = 2,658) and currently married women (N = 37,539) living in India. The Baron and Kenny mediated regression model was used, involving simple logistic and multiple logistic regression, drawing from the National Family Health Survey 2005-2006 (NFHS-3). Sexual violence was not found …

Association Of Hiv Testing, Educational Attainment, And Age Among Black And Non-Black Men, Ashley N. Martell

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Human Immunodeficiency Virus (HIV) infection can lead to a chronic condition, Acquired Immunodeficiency Syndrome (AIDS), but can be well managed with a combination of medications, treatments, and remedies.1 The emergence of HIV in the United States in 1981 created an atmosphere unlike any other at that time. Overtime, the science community has worked diligently to combat this disease through research, practice, and intervention. Although many efforts have been put forth over the past thirty years, millions of Americans still remain infected with HIV.2 Among those who are infected with HIV/AIDS we see disproportionate rates among specific races and gender. Research …

Patterns Of Pneumoconiosis Mortality In Kentucky: Analysis Of Death Certificate Data, Jake Beggs

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

ABSTRACT

Background: Despite ongoing surveillance efforts, mortality rates associated with total pneumoconiosis, and particularly coal worker’s pneumoconiosis, have remained elevated. Methods: Kentucky death certificate data from 2003-2011 was statistically compared to other coal mining states and descriptively analyzed from 2011-2013 to determine the mortality burden and public health implications of pneumoconiosis and coal worker pneumoconiosis (CWP) on Kentucky residents from 2003-2013. Results: Kentucky’s total pneumoconiosis and coal workers’ pneumoconiosis mortality rates decreased from 2003-2009, then increased in following years, showing a significant quadratic trend from 2003-2013 (p<.05) compared to West Virginia, Pennsylvania, and the overall United States rates that had significant negative linear trends from 2003-2011(p<.05). Deaths from pneumoconiosis primarily occurred in white males from CWP in the Appalachian region. Individuals diagnosed with pneumoconiosis died from respiratory illness 50% of the time, heart-related problems (23%) and cancer (12%). Autopsies were only performed on 12% of decedents over the three year study period and the primary locations of death were in hospital (47%) and at home (36%). Conclusions: Increased coal mining industry worker environmental exposure protection should be enhanced in Kentucky. Additionally, healthcare efforts should focus on increasing patient education to ensure early detection and treatment for individuals suffering from pneumoconiosis as well as for comorbid conditions such as Chronic Obstructive Pulmonary Disease. To further target healthcare and treatment of pneumoconiosis patients, increased autopsies of individuals with pneumoconiosis should be performed to identify involvement of other conditions such as silicosis and optimize pneumoconiosis fatality surveillance.

Post-Laminectomy Back Pain: Understanding The Progress From Acute To Chronic Pain State, James Derek Calhoun

DNP Projects

In the United States, 74.6% of patients who have lumbar laminectomy surgery have residual low back pain (Hussain & Erdek, 2014) and overall costs of low back pain may reach up to $200 billion per year (Carey & Frebuger 2013). To further address this problem, a study was conducted to determine if treatment in a chronic pain clinic could result in a reduction in the development of a chronic pain state for adult patients who have had lumbar laminectomy surgeries. A convenience sample of 50 patients was selected from the Interventional Pain Associates clinic at the University of Kentucky. Records …

Human Cardiovascular Responses To Artificial Gravity Variables: Ground-Based Experimentation For Spaceflight Implementation, Mark Howarth

Theses and Dissertations--Biomedical Engineering

One countermeasure to cardiovascular spaceflight deconditioning being tested is the application of intermittent artificial gravity provided by centripetal acceleration of a human via centrifuge. However, artificial gravity protocols have not been optimized for the cardiovascular system, or any other physiological system for that matter. Before artificial gravity protocols can be optimized for the cardiovascular system, cardiovascular responses to the variables of artificial gravity need to be quantified.

The research presented in this document is intended to determine how the artificial gravity variables, radius (gravity gradient) and lower limb exercise, affect cardiovascular responses during centrifugation. Net fluid (blood) shifts between body …

Considering The Human And Nonhuman In Literary Studies: Notes For A Biographic Network Approach For The Study Of Literary Objects, Edward L. Bullock

Theses and Dissertations--English

In recent years critical projects spanning philosophy, the social sciences, science studies, and nearly everywhere that has employed the term ecology have engaged in thinking humans and non-humans together as collectively producing outcomes, where objects do work beyond how humans perceive or make use of them. Taking Zelda Fitzgerald’s Save Me the Waltz as its focus, this thesis explores how this reorientation might contribute to literary studies and to literary criticism more specifically. The thesis considers a notion that novels constitute objects with biographies running “against” the biographic material of their authors, mobilizes actor network theory as a manner of …

Is There A Relationship Between Hip Structure, Hip Muscle Strength, And Lower Extremity Frontal Plane Kinematics During Treadmill Running?, Michael William Robinson Baggaley

Theses and Dissertations--Kinesiology and Health Promotion

INTRODUCTION: Excessive hip adduction (HADD) has been associated with a number of lower extremity overuse injuries, and it has been suggested that it may be the result of reduced strength of the hip abduction musculature. Hip structure has been postulated to influence both hip abduction (HABD) strength and HADD. The purpose of this study was to investigate the relationship between hip structure, HABD strength, and frontal plane kinematics during running. METHODS: Peak isometric HABD strength, lower extremity kinematics, femoral neck-shaft angle (NSA), and pelvis width-femur length (pw-fl) ratio were recorded for 25 female subjects. Pearson correlations (P < .05) were performed between variables. RESULTS: A fair relationship was observed between femoral NSA and HABD strength (r = …

Development Of A Moldable Composite Bone Graft Substitute Releasing Antibacterial And Osteogenic Drugs, Matthew E. Brown

Theses and Dissertations--Biomedical Engineering

Large infected bone defects (IBD) are very complicated to treat due to their high variability; they often require multiple procedures. Bone autografts are the gold standard for treatment but have several drawbacks, such as a need for a second surgery site, limited grafting material, and donor site morbidity. The objective of this research was to develop a moldable synthetic bone grafting material capable of releasing both antimicrobial and osteogenic drugs over a clinically relevant time course for the treatment of IBDs. Current treatment methods for large IBDs require two separate procedures to treat the bone defect and the infection.

This …

The Study Of Trunk Mechanical And Neuromuscular Behaviors, Brian D. Koch

Theses and Dissertations--Biomedical Engineering

Low back pain (LBP) is a common ailment in the United States, affecting up to 80% of adults at least once in their lifetime. Although 90% of LBP cases are considered nonspecific, recent studies show that abnormal mechanics of the lower back can be a major factor. One method of assessing the lower back mechanical environment is through perturbation experiments. An intensive literature review of perturbation systems was used to select and develop a system for the Human Musculoskeletal Biomechanics Lab (HMBL). Following construction, individuals with high/low exposure to day-long physical activity were assessed to quantify daily changes in their …

Stabilization Of Extended Diffuse Optical Spectroscopy Measurements On In Vivo Human Skeletal Muscle During Dynamic Exercise, Brad A. Henry

Theses and Dissertations--Biomedical Engineering

This research investigates various applications of diffuse correlation spectroscopy (DCS) on in-vivo human muscle tissue, both at rest and during dynamic exercise. Previously suspected muscle tissue relative blood flow (rBF) baseline shift during extended measurement with DCS and DCS-Near infrared spectroscopy (NIRS) hybrid optical systems are verified, quantified, and resolved by redesign of optical probe and alteration in optical probe attachment methodology during 40 minute supine bed rest baseline measurements. We then translate previously developed occlusion techniques, whereby rBF and relative oxygen consumption rV̇O₂ are calibrated to initial resting absolute values by use of a venous occlusion (VO) and …

Bioerodible Calcium Sulfate Bone Grafting Substitutes With Tailored Drug Delivery Capabilities, Bryan R. Orellana

Theses and Dissertations--Biomedical Engineering

Bone regeneration or augmentation is often required prior to or concomitant with implant placement. With the limitations of many existing technologies, a biologically compatible synthetic bone grafting substitute that is osteogenic, bioerodible, and provides spacing-making functionality while acting as a drug delivery vehicle for bioactive molecules could provide an alternative to ‘gold standard’ techniques.

In the first part of this work, calcium sulfate (CS) space-making synthetic bone grafts with uniformly embedded poly(β-amino ester) (PBAE) biodegradable hydrogel particles was developed to allow controlled release of bioactive agents. The embedded gel particles’ influence on the physical and chemical characteristics of CS was …

Mucoadhesive Films For Treatment Of Local Oral Disorders: Development, Characterization And In Vivo Testing, Sandeep K. Ramineni

Theses and Dissertations--Biomedical Engineering

Mucoadhesive drug delivery systems which are being used from 1980’s to avoid first pass metabolism of drugs, commercially exist for only systemic drug delivery with fast erosion times (15-60 min), that may not be appropriate for local oral disorders. The goal of this research was to develop and characterize mucoadhesive films with flexibility of carrying different drugs and proteins and provide sustained release for local treatment of oral disorders.

Mucoadhesive films composed of polyvinylpyrrolidone (PVP) and carboxymethlycellulose (CMC) were formulated with imiquimod, an immune response modifier. Problems such as solubilization of imiquimod to increase drug loading, uniformity in films and …

Relationships Of Long-Term Bisphosphonate Treatment With Measures Of Bone Microarchitecture And Mechanical Competence, Jonathan Joseph Ward

Theses and Dissertations--Biomedical Engineering

Oral bisphosphonate drug therapy is a common and effective treatment for osteoporosis. Little is known about the long-term effects of bisphosphonates on bone quality. This study examined the structural and mechanical properties of trabecular bone following 0-16 years of bisphosphonate treatment. Fifty-three iliac crest bone samples of Caucasian women diagnosed with low turnover osteoporosis were identified from the Kentucky Bone Registry. Forty-five were treated with oral bisphosphonates for 1 to 16 years while eight were treatment naive. A section of trabecular bone was chosen from a micro-computed tomography (Scanco µCT 40) scan of each sample for a uniaxial linearly elastic …

Additives To Control Mechanical Properties And Drug Delivery Of Injectable Polymeric Scaffolds, Paul Fisher

Theses and Dissertations--Biomedical Engineering

In situ forming implants (ISIs) are popular due to their ease of use and local drug delivery potential, but they suffer from high initial drug burst, and release behavior is tied closely to solvent exchange and polymer properties. Additionally, such systems are traditionally viewed purely as drug delivery devices rather than potential scaffold materials due to their poor mechanical properties and minimal porosity. The aim of this research was to develop an injectable ISI with drug release, mechanical, and microstructural properties controlled by micro- and nanoparticle additives.

First, an injectable ISI was developed with appropriate drug release kinetics for orthopedic …

The Prophets And Profits Of Pleasure An Analysis Of Florida’S Development From The Civil War To The Turn Of The 20Th Century, Christopher Mark Esing

Theses and Dissertations--History

This dissertation examines the emergence of Florida from the end of the Civil War to the beginning of the twentieth century through the lenses of Jacksonville, Pensacola, Tampa, and Miami as they became the major economic and social centers within the state. Influenced by Union and Republican ideologies, early immigration tracts promised egalitarian land development rooted in the promise of citrus, diversified agriculture, real-estate, and the promise of tourism. As more northerners came to rely upon cheap black labor to make their dream a reality, the earlier narrative of egalitarianism began to loose ground to the demands for inexpensive labor. …

Black Power In River City: African American Community Activism In Louisville, Kentucky, 1967-1970, Zack G. Hardin

Theses and Dissertations--History

The impact of Black Power rhetoric and ideology in Louisville, Kentucky in 1967-1970 is explored. The role of Black Power in shaping the discourse of Louisville’s black counter-public and civil rights counter-public is analyzed in the context of the 1967 open housing demonstrations, the May, 1968 riot, and the trial of the ‘Black Six’. Black Power played a vital role in community organizing and in displays of black national and cultural pride. It actively challenged the city’s mystique of Southern white paternalism embraced by the mayoral administration of Kenneth Schmied. Despite that administrations allegations, Black power rhetoric in the West …

Analysis Of The Role Of Two Autophagy Pathway Related Genes, Becn1 And Tsc1, In Murine Mammary Gland Development And Differentiation, Amber N. Hale

Theses and Dissertations--Biology

The mammary gland is a dynamic organ that undergoes the majority of its development in the postnatal period in four stages; mature virgin, pregnancy, lactation, and involution. Every stage relies on tightly regulated cellular proliferation, programmed cell death, and tissue remodeling mechanisms. Misregulation of autophagy, an intracellular catabolic process to maintain energy stores, has long been associated with mammary tumorigenesis and other pathologies. We hypothesize that appropriate regulation and execution of autophagy are necessary for proper development of the mammary ductal tree and maintenance of the secretory epithelia during late pregnancy and lactation. To test this hypothesis we examined the …

Renal Humoral, Genetic And Genomic Mechanisms Underlying Spontaneous Hypertension, Jason A. Collett

Theses and Dissertations--Biology

In spite of significant progress in our knowledge of mechanisms that control blood pressure, our understanding of the pathogenesis of hypertension, its genetics, and population efforts to control blood pressure, hypertension remains the leading risk factor for mortality worldwide. It’s estimated that 1 out of every 3 adults has hypertension. Hypertension is a major risk factor for cardiovascular disease and stroke, and is considered a primary or contributing cause of death to more than 2.4 million US deaths each year. Although spontaneous hypertension has been the subject of substantial research, many critical questions remain unanswered.

To investigate mechanisms underlying spontaneous …

Katherine Mansfield Among The Moderns: Her Impact On Virginia Woolf, D. H. Lawrence, And Aldous Huxley, Nicola Anne Tarrant-Hoskins

Theses and Dissertations--English

Katherine Mansfield among the Moderns examines Katherine Mansfield’s relationship with three fellow writers: Virginia Woolf, D. H. Lawrence, and Aldous Huxley, and appraises her impact on their writing. Drawing on the literary and the personal relationships between the aforementioned, and on letters, diaries, and journals, this project traces Mansfield’s interactions with her contemporaries, providing a richer and more dynamic portrait of Mansfield’s place within modernism than usually recognized.

Hitherto, critical work has not scrutinized Mansfield in the manner I suggest: attending to representations of her as a character in other’s work, while analyzing the degree to which her influence on …

Buying A Colonial Dream: The Role Of Lifestyle Migrants In The Gentrification Of The Historic Center Of Granada, Nicaragua, Abigail Foulds

Theses and Dissertations--Geography

This dissertation aims to expand our understanding of how lifestyle migrants from the Global North impact the urban space of a Global South city, particularly the built environment. In order to situate the questions posed in this dissertation, I focus on how lifestyle migrants from the Global North and their foreign capital transform the city of Granada, Nicaragua through processes of gentrification, and how the social and economic climate of the city and its residents are impacted. This research allows for empirically informed theoretical critiques to be made about the economic and social implications of the globalization of gentrification resulting …

Life On The Big Slab: Identity And Mobility In The United States Trucking Industry, Valerie J. Keathley

Theses and Dissertations--Geography

Many changes have occurred in the United States trucking industry over the last thirty years. This study examines the effects of these changes by looking at three related themes: life on the road and life at home, body image and bodily health, and the experiences of women and sexual minorities in the industry. This research is based on a discourse analysis of interviews conducted with truck drivers and trucking industry leaders.

Most truck drivers say that they value the independent nature of their workplace. Yet the independence that is a part of the trucker mystique is challenged by increased surveillance …

Effectiveness Of A Farm Field Trip, Bonnie S. Sigmon

Theses and Dissertations--Community & Leadership Development

The annual Sigmon Farm Tour was started in 1992 as an agricultural education program where students could experience being on a farm with the goal of increasing the agricultural literacy levels of the participants. Every year the entire 4th grade student population of Rockcastle County spends the day touring the farm and participating in experiential mini lessons given by the cooperating farm service and health agencies. The program has continued for 20+ years without an evaluation as to whether it is achieving its objectives. This evaluation will also exhibit the programs strengths and weakness so it can continue to improve. …

Drumming Away Drugs: An Innovative Alternative Towards Drug Rehabilitation, John C. Hill

Theses and Dissertations--Community & Leadership Development

Drug use poses a serious threat to the quality of life for many Kentuckians and their families. Recent statistics indicate drug offenders account for a significant portion (in one year, 52,597 arrests were made for drug violations statewide) of individuals within thecriminal justice system, directly affecting the economic vitality within our state (Bunn & Slavova, 2012; Federal Bureau of Investigation, 2012). These statistics signify an overwhelming need for effective prevention efforts and innovative treatment alternatives. This study provides an innovative alternative treatment for drug offenders that infuses social and emotional coping strategies using percussion as a context. During the innovative …

Family Influences On The Educational Aspirations Of Female Youth In Appalachia, Leah K. Vance

Theses and Dissertations--Community & Leadership Development

Family support, both financial and social, can impact the educational aspirations of youth. Studies have shown gender also plays a role in those educational aspirations. While there has been some research done on the educational aspirations of youth in Appalachia, the research on female youth Appalachia is less explored.

This study looks at the educational aspirations of female youth in Appalachia by surveying a group of young women who belong to the Robinson Scholars at the University of Kentucky. Participants completed a brief, one time survey answering questions about the types of social support received and the providers of that …

Evaluating Sampling Strategies For Rainfall Simulation Studies And Surface Transport Of Antibiotics From Swine Manure Applied To Fescue Plots, Holly K. Enlow

Theses and Dissertations--Biosystems and Agricultural Engineering

Antibiotics are commonly used in animal agriculture to treat and prevent diseases and promote growth. Unfortunately, large amounts of antibiotics are not metabolized, but instead are excreted in urine and feces. Rainfall simulation studies were used to investigate the transport of the antibiotic oxytetracycline and various constituents in runoff and the ability of alum to reduce pollutant transport. Runoff samples were collected at several points during the simulated storm event from each of four treatments: control (C), manure only (M), manure and antibiotics (MA), and manure, antibiotics and alum (MAA). Flow-weighted composite samples were created and compared to the flow …

Calpain 5: A Non-Classical Calpain Highly Expressed In The Cns And Localized To Mitochondria And Nuclear Pml Bodies, Ranjana Singh

Theses and Dissertations--Neuroscience

Calpain 5 (CAPN5) is a non-classical member of the calpain family. It lacks the EF-hand motif characteristic of the classical calpains, calpain 1 and 2, but retains catalytic and Ca²⁺ binding non EF domains. Tra-3, an ortholog of CAPN5, is involved in necrotic cell death in C.elegans; although specific role of CAPN5 has not been investigated in the mammalian CNS. I compared relative mRNA levels of calpains in rat CNS, which revealed that CAPN5 is the second most highly expressed calpain. We examined relative levels of CAPN5 from late embryonic day 18 to postnatal day 90 and …

Modulation Of Vaccine-Induced Responses By Anthelmintic Treatment In Ponies, Emily Rubinson

Theses and Dissertations--Medical Sciences

Vaccines and anthelmintics induce an inflammatory response in equids. Since they are commonly given concurrently, it is practical to study any interaction between them. This study evaluated whether IVM and PYR would modulate the acute phase inflammatory response, the systemic gene expression of pro-inflammatory cytokines, and vaccine-specific titers induced by WNV, EHV, and KLH vaccines. Naturally-infected, yearling ponies were sorted by gender, then fecal epgs. They were randomly assigned to three treatment groups: IVM, PYR, and control. All ponies received vaccinations intramuscularly on days 0 and 29. Whole blood, serum, and plasma samples were collected 1, 3, and 14 days …

Listeria Monocytogenes Can Utilize Both M Cell Transcytosis And Inla-Mediated Uptake To Cross The Epithelial Barrier Of The Intestine During An Oral Infection Model Of Listeriosis, Hilary Denney

Theses and Dissertations--Medical Sciences

The invasive pathways, InlA- and InB-mediated uptake and M cell transcytosis, that Listeria monocytogenes uses to invade the intestine have mainly been studied using infection models that do not truly replicate what occurs during a natural infection. Recently, our lab has developed an oral infection model that is more physiolocally relevant to what occurs during food borne listeriosis. We have sought to evaluate the relative roles of the previously defined invasive pathways, in our oral model of infection. We have done this by utilizing an InlAmCG Lm strain that is able to bind murine E-cadherin, knockout Lm strains, ΔinlA Lm …

Dopamine And Glutamate Dysfunction In A Rodent Model Of Attention-Deficit/Hyperactivity Disorder: Implications For Future Neuropharmacology, Erin M. Miller

Theses and Dissertations--Neuroscience

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common disorders of childhood. It is theorized to be caused by catecholamine dysfunction in the striatum (Str) and frontal cortex (FC). The spontaneously hypertensive rat (SHR) has been used as a model for ADHD because of its attention deficits, impulsiveness, and hyperactivity. Prior studies of dopamine (DA) in the Str and FC have revealed conflicting results in the SHR compared to control, indicative of a need for a better understanding of DA dynamics in this model. In addition to the DA hypothesis, studies have begun implicating glutamate in the etiology of ADHD. …

Immunotherapy In Combination With Behavioral Enrichment In A Canine Model Of Aging, Paulina R. Davis

Theses and Dissertations--Pharmacology and Nutritional Sciences

Alzheimer’s disease (AD) is characterized by cognitive decline and hallmark neuropathology, including β-amyloid (Aβ). Therapeutic strategies for AD are focusing on reducing Aβ. Canines develop Aβ neuropathology and cognitive decline with age similar to AD patients. In previous studies, immunization with Aβ1-42 (VAC) in aged canines decreased brain Aβ but did not improve cognition. Behavioral enrichment (ENR) improved cognition without reducing brain Aβ. We hypothesized that VAC combined with ENR would provide cognitive benefits and reduce Aβ neuropathology, as compared individual VAC and ENR treatments. Aged beagles were placed into groups: control, VAC with fibrillar Aβ1-42, ENR, and combination treatment …