Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Kentucky

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 1261 - 1290 of 18291

Full-Text Articles in Entire DC Network

Nothing Short Of Superheroic: A Quantitative Study Of Lifetime Exposure To Superhero Comic Book Media As A Predictor Of Attitudes Towards Diversity, Equity, And Inclusion, Michael Nguyen Jan 2025

Nothing Short Of Superheroic: A Quantitative Study Of Lifetime Exposure To Superhero Comic Book Media As A Predictor Of Attitudes Towards Diversity, Equity, And Inclusion, Michael Nguyen

Theses and Dissertations--Educational Leadership Studies

This dissertation examined the relationship between lifetime exposure to superhero comic book media and attitudes toward diversity, equity, and inclusion (DEI). Drawing on theories of identity formation—transitional objects, parasocial relationships, and cultivation theory—it investigated whether engagement with superhero narratives predicted DEI attitudes. Using quantitative methods, data from 499 U.S. adults were collected via Qualtrics. Two instruments were used: the Lifetime Superhero Comic Book Media Exposure Scale (LSES) and the Intolerant Schema Measure (ISM), which assessed prejudice across race, gender, sexuality, class, age, and religion. Multiple linear regression revealed that superhero media exposure significantly predicted ISM scores (B = 0.118, …


Exploring The Collective Efficacy Of Elementary Special Education Teachers And Its Relationship To Distributed Leadership, Emma L. Jones Jan 2025

Exploring The Collective Efficacy Of Elementary Special Education Teachers And Its Relationship To Distributed Leadership, Emma L. Jones

Theses and Dissertations--Educational Leadership Studies

This study examined the relationship between collective teacher efficacy (CTE) and distributed leadership practices among elementary special education teachers. CTE reflects teachers’ shared belief in their collective ability to improve student outcomes, while distributed leadership emphasizes shared decision-making, collaboration, and shared responsibility across school personnel.

Using a sequential explanatory mixed-methods design, the study combined survey data from the Collective Teacher Belief Scale with follow-up interviews. Survey results from 31 special education teachers indicated moderate to high levels of CTE, with slightly greater confidence in managing student behavior than in delivering instruction. Interviews with teachers across varying CTE levels provided deeper …


Effect Of Walking With An Active Ankle Exoskeleton On The Biomechanical Responses Of The Lumbar Spine, Jose E. Rubio, Junfei Tong, Aravind Sundaramurthy, Anup Pant, Sridevi Nagaraja, Meredith K. Owen, Michael A. Samaan, Brian W. Noehren, Jaques Reifman Jan 2025

Effect Of Walking With An Active Ankle Exoskeleton On The Biomechanical Responses Of The Lumbar Spine, Jose E. Rubio, Junfei Tong, Aravind Sundaramurthy, Anup Pant, Sridevi Nagaraja, Meredith K. Owen, Michael A. Samaan, Brian W. Noehren, Jaques Reifman

Physical Therapy Faculty Publications

Objective: Musculoskeletal injuries pose a health threat to U.S. Service members. In particular, the physical demands of walking and running with load carriage contribute to a high incidence of musculoskeletal injuries of the lower back. Active ankle exoskeleton devices are promising technologies that may help mitigate the impact of load carriage on the incidence of these injuries. However, the safe extended use of these devices requires an understanding of their beneficial or detrimental effects on the lumbar spine. In this pilot study, we investigated the impact of walking with an ankle exoskeleton device on lumbar biomechanical responses.

Methods: We collected …


Comparison Of Machine Learning Models For Colon Cancer Survival: Predictive Modeling Approach, Reuben Adatorwovor, Motolani E. Ogunsanya, Bin Huang, Richard Charnigo, Olufunmilola Abraham Jan 2025

Comparison Of Machine Learning Models For Colon Cancer Survival: Predictive Modeling Approach, Reuben Adatorwovor, Motolani E. Ogunsanya, Bin Huang, Richard Charnigo, Olufunmilola Abraham

Biostatistics Faculty Publications

Background: Colon cancer is a leading cause of cancer-related deaths worldwide, with survival influenced by risk factors, treatment type, and patient characteristics. Traditional statistical models, such as Kaplan-Meier curves, have been widely used to estimate survival probabilities. However, these models often have difficulty handling complex interactions, covariates, and nonlinear relationships between risk factors. Recently, machine learning (ML) techniques have emerged as promising tools for improving survival prediction by handling large covariates and capturing complex patterns.

Objective: This study compares several ML models to accurately estimate colon cancer survival by leveraging data from the Kentucky Cancer Registry. By identifying key risk …


Incident Atherosclerotic Cardiovascular Disease Among Veterans By Gender Identity: A Cohort Study, Carl G. Streed Jr., Meredith S. Duncan, Kory R. Heier, T. Elizabeth Workman, Lauren B. Beach, Guneet K. Jasuja, Hill L. Wolfe, Landon D. Hughes, John R. O’Leary, Melissa Skanderson, Joseph L. Goulet Jan 2025

Incident Atherosclerotic Cardiovascular Disease Among Veterans By Gender Identity: A Cohort Study, Carl G. Streed Jr., Meredith S. Duncan, Kory R. Heier, T. Elizabeth Workman, Lauren B. Beach, Guneet K. Jasuja, Hill L. Wolfe, Landon D. Hughes, John R. O’Leary, Melissa Skanderson, Joseph L. Goulet

Biostatistics Faculty Publications

Background: Transgender and gender diverse (trans) populations are at elevated risk for atherosclerotic cardiovascular disease (ASCVD).

Objective: Measure the association of gender identity and gender-affirming hormone therapy (GAHT) with ASCVD outcomes.

Design: Cohort study.

Participants: Over 1 million veterans receiving care in the Veterans Health Administration.

Main Measures: Gender identity was identified via a validated natural language processing (NLP) algorithm. Incident ASCVD (acute myocardial infarction, ischemic stroke, or revascularization after the baseline date) was identified via International Classification of Diseases diagnosis codes among veterans without prevalent ASCVD. We calculated sample statistics stratified by gender identity and used Cox proportional hazard …


Examples Of Storytelling In Tan Dun’S The Banquet Piano Sonata, Ni Zhan Jan 2025

Examples Of Storytelling In Tan Dun’S The Banquet Piano Sonata, Ni Zhan

Theses and Dissertations--Music

The Banquet is a 2006 Chinese martial arts film directed by Feng Xiaogang. Chinese-American composer Tan Dun was invited to create the film's original soundtrack. In 2016, Tan adapted the music from the soundtrack into a four-movement piano sonata, also titled The Banquet, using melodies from the original film score. This document examines The Banquet Piano Sonata’s connection to the film’s narrative. It explores ways in which the storytelling of the film is used in the sonata; this is accomplished through three key aspects depicted in the music: culture, atmosphere, and inner emotions.


Teacher Perceptions Of A Mindful-Based Social Emotional Group Drumming Curriculum: A Collective Case Study, Kristin Lewis Jan 2025

Teacher Perceptions Of A Mindful-Based Social Emotional Group Drumming Curriculum: A Collective Case Study, Kristin Lewis

Theses and Dissertations--Music

Educational researchers have discovered a connection between educator and student well-being. Educators need to cultivate these skills to effectively model social emotional learning (SEL). However, there is a shortage of resources for elementary general music educators that intentionally embed social emotional competencies in tandem with adhering to the National Core Arts Standards.

Therefore, the purpose of this study was to examine elementary music educators’ perceptions of a Mindfulness-Based Social Emotional Learning (MBSEL) group drumming curriculum and its impact on their own and their students’ social emotional competencies (SECs). The research questions were: (1) What are elementary music educators’ perceptions of …


Anatomical Literacy And Body Mapping In Flute Performance: Strategies For Addressing And Preventing Upper Extremity Injuries, Lauren E. Wiedemer Jan 2025

Anatomical Literacy And Body Mapping In Flute Performance: Strategies For Addressing And Preventing Upper Extremity Injuries, Lauren E. Wiedemer

Theses and Dissertations--Music

This document investigates the benefits of incorporating the study of anatomy and Body Mapping into flute performance, specifically focusing on addressing and preventing injuries related to the upper extremities. As the physical demands on musicians continue to grow, this research advocates for recognizing flutists as "musical athletes.” It highlights the importance of anatomical literacy and somatic awareness in sustaining performance longevity. The practical applications of Body Mapping are explored in detail and presents strategies for alleviating strain and fostering ease of movement, supported by research and experiential insights. Pedagogical recommendations are offered to integrate these principles into flute instruction, helping …


Hardcore And Metal Music In Music Therapy: A Functional Guide For Music Therapists And Music Therapy Students, Caroline Nc Wood Jan 2025

Hardcore And Metal Music In Music Therapy: A Functional Guide For Music Therapists And Music Therapy Students, Caroline Nc Wood

Theses and Dissertations--Music

Hardcore and metal music have long been misrepresented, stigmatized, and dismissed in music academia, and overlooked in music therapy literature and education. However, these genres hold significant emotional, cultural, and therapeutic value for many listeners, offering unique opportunities for connection, expression, catharsis, and healing. This thesis presents a practical, introductory guide to help music therapists and music therapy students gain an understanding of why, when, and how to effectively and authentically incorporate hardcore and metal music into clinical practice. The project explores the historical development of these genres; sociocultural associations and considerations, including stigmatization, sensationalism, and the juxtaposing sociopolitical dynamics …


A Comparison Of Informal Choral Singing Experiences, Christopher Powell Jan 2025

A Comparison Of Informal Choral Singing Experiences, Christopher Powell

Theses and Dissertations--Music

A traditional choir relies on the interest and participation of the population in communal singing. However, drawing willing participants into a traditional choir program can often prove challenging to music educators, community choir directors, and leaders of religious music programs. One of the most prevalent informal singing groups in the USA is Sacred Harp. Sacred Harp “singings” have been around since the early years of The Sacred Harp itself. These singings occur regularly in multiple locations across the country and around the world. These events have an open atmosphere and, despite the mostly Christian material, have no expectation of a …


Designing An Undergraduate Opera Workshop Curriculum For Universities, Christopher L. Burchett Jan 2025

Designing An Undergraduate Opera Workshop Curriculum For Universities, Christopher L. Burchett

Theses and Dissertations--Music

The world of opera is quickly evolving to keep pace with the other arts forms of film, television and Broadway theater. For many years the genre had been reluctant to change with the times and update the skills of their performers. Those days have passed. Today’s operatic performers must be better actors, better movers and more theatrically efficient with their overall skill set in addition to having the secured singing technique that has for so long been the top priority. Universities must take ownership of this training.

Today’s university opera workshop programs must be more than they have been in …


Secondary String Students’ Perceptions Of The Role Of Self-Efficacy In Mitigating Their Musical Performance Anxiety: A Collective Case Study, Mary E. Henton Jan 2025

Secondary String Students’ Perceptions Of The Role Of Self-Efficacy In Mitigating Their Musical Performance Anxiety: A Collective Case Study, Mary E. Henton

Theses and Dissertations--Music

Musical Performance Anxiety (MPA) is a multifaceted psychological condition that arises before, during, or after musical performance and presents a significant obstacle for young musicians, particularly secondary string students. Closely linked to the spotlight effect and social anxiety, MPA has worsened among youth following the COVID-19 pandemic due to decreased social interaction, both of which have had adverse effects on students’ mental health. Despite teachers’ awareness of MPA’s prevalence, music education programs often lack instruction in specific coping mechanisms to address it, and many students do not seek support or treatment.

The purpose of this study was to describe the …


A Twenty-First Century Approach To Darius Milhaud's Saudades Do Brasil, Paige H. Crain Jan 2025

A Twenty-First Century Approach To Darius Milhaud's Saudades Do Brasil, Paige H. Crain

Theses and Dissertations--Music

French composer Darius Milhaud (1892-1974) lived in Rio de Janeiro, Brazil from February 1917 to November 1918. Milhaud’s experience in Rio was overwhelmingly positive, and several of his works were influenced by this period of his life, one being a suite for solo piano titled Saudades do Brasil, Op. 67. Inspired by Brazilian popular music, this piece is an example of exoticism, a trend of writing music based on cultures other than the composer’s own. Considering that exoticism historically has the potential to perpetuate harmful stereotypes or generate false information, this research delves into Saudades do Brasil, exploring …


Professional Experiences Of Disabled Music Therapists: An Adapted Multiple Case Study, August Lily Tuggle Jan 2025

Professional Experiences Of Disabled Music Therapists: An Adapted Multiple Case Study, August Lily Tuggle

Theses and Dissertations--Music

Literature about disability often focuses on disabled people as recipients of professional services and there is scant literature about disabled professionals. Although music therapists work primarily with disabled individuals, there is little research on or from the perspectives of disabled music therapists. A growing body of qualitative research, grey literature, and media platforms provides perspectives from the disability community regarding music therapy. Disabled individuals both within and outside the profession critique common music therapy attitudes and practices that conflict with the expressed needs of the disability community. However, much of this literature contains the perspectives of one individual or a …


Integrating Deconstruction And Historic Preservation: A Best Practices Policy Comparison, Kelsey M. Baldwin Jan 2025

Integrating Deconstruction And Historic Preservation: A Best Practices Policy Comparison, Kelsey M. Baldwin

MPA/MPP/MPFM Capstone Projects

Carl Elefante, the former president of the American Institute of Architects, famously said, “The greenest building is…one that is already built” (Elefante, 2012). Elefante articulated the environmental benefits of reuse and the significant energy costs associated with demolition and new construction. In 2022, the commercial and residential building sectors produced 31% of the United States’ greenhouse gas (GHG) emissions (EPA, 2025). A large percentage of this is tied to the production of building materials.


Managing Kentucky's Coal Severance Tax Decline: Lessons From Other States, Ryan Reed Jan 2025

Managing Kentucky's Coal Severance Tax Decline: Lessons From Other States, Ryan Reed

MPA/MPP/MPFM Capstone Projects

Governments levy severance taxes on the extraction of natural resources such as coal, oil, and natural gas. This can be a substantial source of revenue for these entities, but overreliance on this has led to what is now known through extensive research as the so-called ‘resource curse’. This has been observed to create political instability, corruption, and repression within resource-rich areas. Additionally, it cripples the ability of the area to pursue future non-resource related economic development after the resource is depleted. A Sovereign Wealth Fund has been touted as one such solution to bridge this gap as an intergenerational wealth …


Targeted Federal Advocacy For Financial Stability: Recommendations For United Way Of The Bluegrass, Jefferson Abney, Lou Hurst Jan 2025

Targeted Federal Advocacy For Financial Stability: Recommendations For United Way Of The Bluegrass, Jefferson Abney, Lou Hurst

MPA/MPP/MPFM Capstone Projects

Advocacy refers to activities undertaken with the intent of influencing policy change. For nonprofit organizations, advocacy can be a critical aspect of furthering their mission. Successful advocacy requires a comprehensive, dynamic understanding of the needs and priorities of stakeholders, as well as an understanding of the political context in which the organization operates and the challenges and opportunities that context poses for its institutional goals. A policy agenda helps nonprofit organizations identify and communicate the most pertinent policy needs for consideration when making decisions around advocacy.

For this project, in response to a request from United Way of The Bluegrass …


Mortgage Lending Discrimination: Racial Differences In A Post-Covid Society, Zachary Owen Jan 2025

Mortgage Lending Discrimination: Racial Differences In A Post-Covid Society, Zachary Owen

MPA/MPP/MPFM Capstone Projects

Researchers have studied the disparities of the mortgage lending process extensively, but their research fails to examine the process following the COVID-19 pandemic. Throughout the aftermath of the pandemic, home sale prices increased, interest rates rose, and rental costs skyrocketed. As such, the housing landscape changed drastically, and research must be conducted to assess new trends and relationships. In this report, I will estimate the relationship between applicant characteristics, such as race, debt-to-income ratio, and income and the outcome of their mortgage loan application and their expected credit score. Prior to COVID-19, Black and White applicants for mortgage loans were …


Reforming Need: How Certificate Of Need Laws In North Carolina Can Be Reformed To Promote Rural To Regional Health Network Integration, Taylor Fulk Jan 2025

Reforming Need: How Certificate Of Need Laws In North Carolina Can Be Reformed To Promote Rural To Regional Health Network Integration, Taylor Fulk

MPA/MPP/MPFM Capstone Projects

Across North Carolina, many rural hospitals are facing closures, staffing shortages, and financial turmoil. Many hospitals, such as Morehead Hospital in Eden, NC (now UNC Rockingham), have utilized mergers with larger regional networks (e.g., UNC Health, Duke, Novant, Atrium) to stabilize operations and preserve local access to care. (deBruyn, 2017). However, even after successful integration efforts to bring some rural hospitals into larger regional networks, Certificate of Need laws in North Carolina are preventing these smaller, rural integrated hospitals from expanding their service offerings, thereby driving up healthcare expenditures for residents. As a result, patients experience longer-than-normal travel times and …


Boys & Girls Clubs Of Greater Cincinnati Strategic Plan, Emily Yellman Jan 2025

Boys & Girls Clubs Of Greater Cincinnati Strategic Plan, Emily Yellman

MPA/MPP/MPFM Capstone Projects

After-school organizations nationwide, such as Boys & Girls Clubs, provide youth with out-of-school opportunities for academic and social-emotional learning. Strategic plans can help after-school organizations maximize their impact. This paper outlines a strategic plan for Boys & Girls Clubs of Greater Cincinnati, specifically to increase the number of members they serve on an average daily basis. The plan addresses both Club member recruitment and retention techniques, and includes specific action items, communication, and monitoring plans.


Improvement Of Cellular Pattern Organization And Clarity Through Centrifugal Force, Lauren E. Mehanna, James D. Boyd, Shelley Remus-Williams, Nicole M. Racca, Dawson P. Spraggins, Martha E. Grady, Brad J. Berron Jan 2025

Improvement Of Cellular Pattern Organization And Clarity Through Centrifugal Force, Lauren E. Mehanna, James D. Boyd, Shelley Remus-Williams, Nicole M. Racca, Dawson P. Spraggins, Martha E. Grady, Brad J. Berron

Chemical and Materials Engineering Faculty Publications

Rapid and strategic cell placement is necessary for high throughput tissue fabrication. Current adhesive cell patterning systems rely on fluidic shear flow to remove cells outside of the patterned regions, but limitations in washing complexity and uniformity prevent adhesive patterns from being widely applied. Centrifugation is commonly used to study the adhesive strength of cells to various substrates; however, the approach has not been applied to selective cell adhesion systems to create highly organized cell patterns. This study shows centrifugation as a promising method to wash cellular patterns after selective binding of cells to the surface has taken place. After …


Integrating Protein Language Model And Molecular Dynamics Simulations To Discover Antibiofouling Peptides, Ibrahim A. Imam, Shea Bailey, Duolin Wang, Shuai Zeng, Dong Xu, Qing Shao Jan 2025

Integrating Protein Language Model And Molecular Dynamics Simulations To Discover Antibiofouling Peptides, Ibrahim A. Imam, Shea Bailey, Duolin Wang, Shuai Zeng, Dong Xu, Qing Shao

Chemical and Materials Engineering Faculty Publications

Antibiofouling peptide materials prevent the nonspecific adsorption of proteins on devices, enabling them to perform their designed functions as desired in complex biological environments. Due to their importance, research on antibiofouling peptide materials has been one of the central subjects of interfacial engineering. However, only a few antibiofouling peptide sequences have been developed. This narrow scope of antibiofouling peptide materials limits their capacity to adapt to the broad spectrum of application scenarios. To address this issue, we searched for antibiofouling peptides in the vast sequence pool of the microbiome library using a combination of deep learning-based high-throughput search and molecular …


Mind The Gap: Supporting Freshmen Voice Students Transitioning To Higher Education Through Coaching Conversations, Erica L. Gabriel Jan 2025

Mind The Gap: Supporting Freshmen Voice Students Transitioning To Higher Education Through Coaching Conversations, Erica L. Gabriel

Theses and Dissertations--Music

The experiences one may encounter while matriculating through the K-12 system of education are vastly different from the world of higher education. While one feeds directly into the other, the transition can be a difficult one for young singers also navigating the developmental leap from adolescence to adulthood. This is due to several systematic and instructional differences, compounded with unique challenges encountered by freshman voice students in the first year. Gaps in support systems compiled with new and increasing financial, social, and academic demands can lead to a decline in overall student well-being and an increase in stress.

This increase …


Treating Social Media Addiction In Adolescents: A Scoping Review With Implications For Music Therapy Practice, Roman D. Swain Jan 2025

Treating Social Media Addiction In Adolescents: A Scoping Review With Implications For Music Therapy Practice, Roman D. Swain

Theses and Dissertations--Music

With the rapid expansion of online connectivity, concerns have emerged regarding the influence of digital interactions on adolescents’ real-world relationships and mental health. Social media use can expose adolescents to harmful content and disrupt the brain’s pleasure centers, increasing the risk of developing addictive patterns of use. Such disruptions may interfere with daily functioning and contribute to negative mental health outcomes. Given the impact of music on the brain’s reward system, music therapy may offer a beneficial approach for helping adolescents develop mindfulness of social media use and strengthen offline social connections. This thesis presents a scoping review of current …


Talking About Cancer And Tobacco (Tact) Study With Lgbtq Patients And Their Care Providers, William Bowling Jan 2025

Talking About Cancer And Tobacco (Tact) Study With Lgbtq Patients And Their Care Providers, William Bowling

Theses and Dissertations--Psychology

Due to multilevel factors, including a high prevalence of tobacco use, the burden of some cancers is disproportionately higher in the lesbian, gay, bisexual, transgender, and queer (LGBTQ) community than the general population. Evidence-based tobacco treatment delivery with high rates of tobacco cessation would be a powerful tool for secondary cancer prevention in the LGBTQ community, yet few studies have explored this issue. The current study aimed to 1) uncover both positive and negative aspects related to the lived experience and treatment of LGBTQ cancer survivors who use tobacco, 2) elucidate barriers and facilitators of tobacco treatment and cessation, and …


Evaluating The Acceptability Of Ptsd Treatment Among Justice-Involved Women In Kentucky With Histories Of Opioid Use, Jesse P. Mccann Jan 2025

Evaluating The Acceptability Of Ptsd Treatment Among Justice-Involved Women In Kentucky With Histories Of Opioid Use, Jesse P. Mccann

Theses and Dissertations--Psychology

Rates of trauma and PTSD as well as histories of opioid use are high among justice-involved women, particularly in Kentucky. However, there are many barriers to receiving treatment. There is a pressing need for brief, trauma-focused interventions that can be more feasibly delivered in jail or prison settings as well as by community clinicians serving women on probation or parole. This study explores the acceptability of treatment for PTSD, particularly Written Exposure Therapy (WET), among justice-involved women on probation or parole with a history of illicit or nonmedical prescription opioid use. The research aims to deepen our understanding of factors …


The Impact Of Victim Posttraumatic Stress Disorder (Ptsd) On Legal Decision-Making In A Rape Trial, Mary M. Levi Jan 2025

The Impact Of Victim Posttraumatic Stress Disorder (Ptsd) On Legal Decision-Making In A Rape Trial, Mary M. Levi

Theses and Dissertations--Psychology

Prior psychology and law research has investigated juror perceptions of victims and defendants with mental health issues. However, one factor that has yet to be fully examined empirically is how the presentation of a victim who developed a mental health disorder, such as posttraumatic stress disorder (PTSD), following a rape impacts legal decision-making. Understanding this impact is crucial considering over 36 million individuals in the United States report being a victim of rape in their lifetime, many of which report developing psychological disorders following the crime. Thus, the present study aimed to investigate how presenting mock jurors with victim testimony …


A Dual Process Model Perspective On Associations Between Parent And Offspring Problem Drinking, Karallyn E. Fitisone Jan 2025

A Dual Process Model Perspective On Associations Between Parent And Offspring Problem Drinking, Karallyn E. Fitisone

Theses and Dissertations--Psychology

Parental problem drinking (PPD) is a well-established risk factor for adolescent alcohol use, yet the complex mechanisms involved remain underexplored. The present study addresses this critical gap by examining how PPD, parent emotion socialization, and emerging adult problem drinking are associated within the framework of the Dual Process Model of Substance Use. Participants were 2,036 undergraduates who completed an online survey assessing PPD, retrospective reports of parental reactions to their negative emotions in childhood, and students’ current levels of problem drinking, negative urgency, negative emotional reactivity, and emotion-regulation difficulties. Structural equation modeling was used to clarify the roles of emotion-related …


Distinct Odorant Receptor Response Patterns To Aliphatic Odorants In Freely Behaving Mice, Claire A. De March, Patrick Breheny, William B. Titlow, Hiroaki Matsunami, Timothy S. Mcclintock Jan 2025

Distinct Odorant Receptor Response Patterns To Aliphatic Odorants In Freely Behaving Mice, Claire A. De March, Patrick Breheny, William B. Titlow, Hiroaki Matsunami, Timothy S. Mcclintock

Physiology Faculty Publications

In mammals, odors are encoded by a combinatorial code determined by the pattern of responses across hundreds of odorant receptors expressed monogenically and monoallelically in olfactory sensory neurons. The compositions of these receptor response patterns are largely unknown and overlap between them has yet to be explored. Activity-dependent reporter gene expression in freely behaving S100a5-tauGFP mice allowed capture of activated olfactory sensory neurons and identified 168 receptors responsive to moderate concentrations of 1 or more of 12 aliphatic (5 to 8 carbons) ketones, alcohols, and carboxylic acids. These 12 response patterns are remarkably different, with only 19% of the receptors …


Feeding- And Light-Cycle Synergistically Regulate Mouse Blood Pressure Daily Rhythm Via Bmal1-Dependent And Independent Mechanisms, Tianfei Hou, Wen Su, Aaron Chacon, An-Hsuan Lin, Zhenheng Guo, Ming C. Gong Jan 2025

Feeding- And Light-Cycle Synergistically Regulate Mouse Blood Pressure Daily Rhythm Via Bmal1-Dependent And Independent Mechanisms, Tianfei Hou, Wen Su, Aaron Chacon, An-Hsuan Lin, Zhenheng Guo, Ming C. Gong

Physiology Faculty Publications

Cardiovascular health requires the orchestration of the daily rhythm of blood pressure (BP), which responds to changes in light exposure and dietary patterns. Whether rhythmic light and feeding can modulate daily BP rhythm directly or via modulating intrinsic core clock gene Bmal1 is unknown. Using inducible global Bmal1 knockout mice (iBmal1KO), we explored the impact of rhythmic light, rhythmic feeding, or their combination on various physiological parameters. Daily rhythms of BP, heart rate, and locomotor activity were monitored via radiotelemetry, while food intake patterns were tracked using the BioDAQ system. Respiratory exchange ratio (RER) and energy expenditure (EE) were assessed …