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Articles 121 - 150 of 18291
Full-Text Articles in Entire DC Network
Mapping The Polar Neuro-Interactome Of Garcinia Mangostana Against The Ad-Pd-Als Nexus, Rahni Hossain, Sirirat Surinkaew, Pradoldej Sompol, Nasmah K. Bastaki, Rifat Jafrin, Nazim Sekeroglu, Jitbanjong Tangpong
Mapping The Polar Neuro-Interactome Of Garcinia Mangostana Against The Ad-Pd-Als Nexus, Rahni Hossain, Sirirat Surinkaew, Pradoldej Sompol, Nasmah K. Bastaki, Rifat Jafrin, Nazim Sekeroglu, Jitbanjong Tangpong
Markey Cancer Center Faculty Publications
Background/Objectives: Neurodegenerative diseases like Alzheimer’s, Parkinson’s, and Amyotrophic lateral sclerosis (ALS) share common molecular pathways, including neuroinflammation and oxidative stress, which complicate the effectiveness of single-target treatments. Garcinia mangostana L. (mangosteen) has shown neuroprotective properties, but previous studies focused on lipophilic xanthones, which have poor bioavailability and uncertain blood–brain barrier permeability. Methods: In the current study, polar metabolites from G. mangostana peel aqueous extract (GMPE) were assessed for potential multi-target interactions via UHPLC-QTOF-MS-based metabolomics, systems pharmacology, and molecular docking analysis. Further, in silico ADMET screening and network-based analyses assessed for overlap between GMPE compounds and genes associated with neurodegeneration (AD, …
Role Of Succinate Dehydrogenase In Age-Related Th17 Inflammation, Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica-Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath
Role Of Succinate Dehydrogenase In Age-Related Th17 Inflammation, Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica-Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath
Markey Cancer Center Faculty Publications
Age-related cellular changes negatively impact CD4+ T cell function. Our prior work showed that mitochondrial complex II (succinate dehydrogenase [SDH]) expression was upregulated in T cells from older (O) adults (60–80 years old). T cells from older adults also produced higher amounts of cytokines generally considered proinflammatory, such as Th17 cytokines IL-17A/F and IL-21, and the Th-17-supportive cytokine IL-6, compared to T cells from younger (Y) adults (25–40 years old). The objective of our study is to evaluate whether hyperactivation of SDH is required for the induction of proinflammatory cytokines and the mechanistic link between SDH and Th17 cytokine …
Systemic Consequences Of Chronic Ethanol Intake, Muni Swamy Ganjayi, Thomas A. Krauss, Gage E. Demster, Sehyung Park, Garrett B. Anspach, Sarah R. Anthony, Shaohua Wang, Michael Tranter, Robert N. Helsley, Cory W. Baumann
Systemic Consequences Of Chronic Ethanol Intake, Muni Swamy Ganjayi, Thomas A. Krauss, Gage E. Demster, Sehyung Park, Garrett B. Anspach, Sarah R. Anthony, Shaohua Wang, Michael Tranter, Robert N. Helsley, Cory W. Baumann
Markey Cancer Center Faculty Publications
Chronic ethanol (EtOH) consumption is a major contributor to multi-organ dysfunction, yet its systemic effects remain incompletely understood. To address this, we utilized a physiologically relevant long-term mouse model, administering 20% EtOH in drinking water for 60 weeks, to investigate the integrated consequences of chronic exposure. EtOH-consuming mice (0.4–0.5 mL/day) exhibited > 30% reductions in chow and fluid intake, resulting in a 12% decrease in total caloric intake compared to controls (p < 0.001). Body mass remained similar until Week 52, after which EtOH-treated mice had lower body mass due to reductions in both lean and fat mass (p ≤ 0.004). Functional assessments revealed impaired treadmill endurance (−17%) and grip strength (−11%) (p ≤ 0.037), while motor coordination remained unaffected (p = 0.203). Chronic EtOH exposure significantly altered gut microbiota composition, reducing Lactobacillus and enriching Faecalibaculum, Clostridium, and Bifidobacterium at the genus level. These changes were accompanied by marked depletion of short-chain fatty acids (p ≤ 0.05). Indirect markers of gut permeability (serum LPS & zonulin) and liver injury (serum ALT & AST, hepatic amyloid content) were elevated, alongside increased total cholesterol and > 62% upregulation of hepatic TNFα, IL-6 & serum amyloid A (p ≤ 0.046). EtOH also induced dyslipidemia and glucose intolerance (p ≤ 0.041), although transcriptomic changes in white adipose …
National Trends And In-Hospital Outcomes Of Valve-In-Valve Transcatheter Aortic Valve Replacement With Cerebral Embolic Protection, Ammar A. Hasnie, Avneet Hans, Emad A. Chishti, Joseph Leith, Hannah Murphy, Alyssa H. Harris, Kory Heier, Kristen Mcquerry, Steve W. Leung, Islam Y. Elgendy
National Trends And In-Hospital Outcomes Of Valve-In-Valve Transcatheter Aortic Valve Replacement With Cerebral Embolic Protection, Ammar A. Hasnie, Avneet Hans, Emad A. Chishti, Joseph Leith, Hannah Murphy, Alyssa H. Harris, Kory Heier, Kristen Mcquerry, Steve W. Leung, Islam Y. Elgendy
Radiology Faculty Publications
No abstract provided.
Impact Of Age And Rurality On Colorectal Cancer Outcomes In The United States, Caitlyn Grunert, Meng Han Tsai, Charles R. Rogers, Sydney Howard, Rachel Hogg-Graham, Courtney Martin, Darwin Conwell, Adetunji T. Toriola, Avinash Bhakta, Justin Moore
Impact Of Age And Rurality On Colorectal Cancer Outcomes In The United States, Caitlyn Grunert, Meng Han Tsai, Charles R. Rogers, Sydney Howard, Rachel Hogg-Graham, Courtney Martin, Darwin Conwell, Adetunji T. Toriola, Avinash Bhakta, Justin Moore
Surgery Faculty Publications
Background: While overall colorectal cancer (CRC) rates have declined in the United States (U.S.), early-onset CRC (EO-CRC), diagnosed before age 50, has increased. Rural U.S. residents face higher CRC incidence than non-rural counterparts. We aimed to examine the relationship between age at diagnosis and EO-CRC outcomes and whether rurality modify these associations. Methods: We analyzed data from 835,907 patients aged 20–79 years in the 2006–2020 SEER Program. Rurality was defined using U.S. Department of Agriculture Rural–Urban Commuting Area (RUCA) codes. Multivariable logistic regression models were used to examine associations between age, rurality, and late-stage CRC diagnosis. Competing-risk regression models were …
Oral Health In People With Schizophrenia, Leire Urien, Ainara Arnaiz, Xabier Marichalar-Mendia, Unax Lertxundi, Jose De Leon, Agate Txurruka, Nerea Jauregizar, Teresa Morera-Herreras
Oral Health In People With Schizophrenia, Leire Urien, Ainara Arnaiz, Xabier Marichalar-Mendia, Unax Lertxundi, Jose De Leon, Agate Txurruka, Nerea Jauregizar, Teresa Morera-Herreras
Psychiatry Faculty Publications
Aim This study aimed to assess the oral health status of individuals with schizophrenia and explore its association with behavioural and pharmacological factors, with particular focus on long-term antipsychotic treatment and cumulative anticholinergic burden. Methods A total of 153 adults with schizophrenia (18–65 years) from the Mental Health Network of Bizkaia (Spain), all under antipsychotic treatment for ≥12 months, were evaluated and compared with 153 controls from the general population. Data on socio-demographic variables, tobacco use and oral hygiene habits were collected. Oral health was assessed using the Decayed, Missing and Filled Teeth (DMFT) index and the Community Periodontal Index …
Generative Models And Synthetic Data In Clinical Prediction Models, Anthony A. Mangino, Taha Ahmed, Vincent L. Sorrell
Generative Models And Synthetic Data In Clinical Prediction Models, Anthony A. Mangino, Taha Ahmed, Vincent L. Sorrell
Radiology Faculty Publications
Introduction: Reproducibility, consistency, and transparency are essential to responsible and ethical scientific inquiry, though practices supporting these qualities are often neglected. However, in many cases data are confidential or otherwise unable to be shared publicly. This tutorial describes a method utilizing generative adversarial networks (GANs) to create synthetic data that are sufficiently similar to the original dataset in such cases where the source data cannot be shared or where the source data are too sparse as to internally validate results. Methods: Utilizing an exemplar study that aimed to create a clinical prediction model employing a novel echocardiographic measurement to differentiate …
The Supreme Court's Goldilocks: Why The Major Questions Doctrine Is The Ideal Compromise Between Two Unattractive Extremes, Bradley P. Simpson
The Supreme Court's Goldilocks: Why The Major Questions Doctrine Is The Ideal Compromise Between Two Unattractive Extremes, Bradley P. Simpson
Kentucky Law Journal
No abstract provided.
The Brave New World Of Judicial Elections, Charles Gardner Geyh
The Brave New World Of Judicial Elections, Charles Gardner Geyh
Kentucky Law Journal
No abstract provided.
A Tale Of Two Landlords, Christopher J. Ryan Jr.
A Tale Of Two Landlords, Christopher J. Ryan Jr.
Kentucky Law Journal
No abstract provided.
The Case For Lgbtq+ Adoption Rights In The Post-Roe Era, Tate Craft
The Case For Lgbtq+ Adoption Rights In The Post-Roe Era, Tate Craft
Kentucky Law Journal
No abstract provided.
Domestic Guestworkers: A Call To End The H-2b Program And Empower American Workers, Preston Huennekens
Domestic Guestworkers: A Call To End The H-2b Program And Empower American Workers, Preston Huennekens
Kentucky Law Journal
No abstract provided.
Party Over Country: The Inability For Congress To Check The Executive, Jordin A. Dickerson
Party Over Country: The Inability For Congress To Check The Executive, Jordin A. Dickerson
Kentucky Law Journal
No abstract provided.
Federal Prosecution In The Shadows Of Constitutional Immunity, J. Richard Broughton
Federal Prosecution In The Shadows Of Constitutional Immunity, J. Richard Broughton
Kentucky Law Journal
No abstract provided.
Executive Immunity, Corruption, And The Rule Of Law: Death By A Thousand Cuts, Kimberly Breedon
Executive Immunity, Corruption, And The Rule Of Law: Death By A Thousand Cuts, Kimberly Breedon
Kentucky Law Journal
No abstract provided.
Happy Belated Iep: How A Notice Of Procedural Safeguards Fails Children With Specific Learning Disabilities, Chrystal Clodomir
Happy Belated Iep: How A Notice Of Procedural Safeguards Fails Children With Specific Learning Disabilities, Chrystal Clodomir
Kentucky Law Journal
No abstract provided.
Dred Scott, Military Enslavement, And The Case For Reparations, Hugh Mcclean
Dred Scott, Military Enslavement, And The Case For Reparations, Hugh Mcclean
Kentucky Law Journal
No abstract provided.
Decolonizing The Law Of The U.S. Virgin Islands, Anthony M. Ciolli
Decolonizing The Law Of The U.S. Virgin Islands, Anthony M. Ciolli
Kentucky Law Journal
No abstract provided.
Building Jerusalem: Commercial Law And Ethics Of The Benefit Corporation, Jeff Lingwall, Susan Park
Building Jerusalem: Commercial Law And Ethics Of The Benefit Corporation, Jeff Lingwall, Susan Park
Kentucky Law Journal
No abstract provided.
Campus Coverage: How Biden's Title Ix Regulations Threaten Free Speech, Academic Freedom, And University Liability, Alex Drury
Kentucky Law Journal
No abstract provided.
The Fall Of America's Final Free Labor Market: Considering The New Age College Athlete As An Employee Under The Nlra And Flsa, Ethan Schaaf
The Fall Of America's Final Free Labor Market: Considering The New Age College Athlete As An Employee Under The Nlra And Flsa, Ethan Schaaf
Kentucky Law Journal
No abstract provided.
Against Activist Cooperation Agreements, Jennifer O'Hare
Against Activist Cooperation Agreements, Jennifer O'Hare
Kentucky Law Journal
No abstract provided.
Methane Emissions From Underground Coal Mines, Marcelo Guzman, Thomas Parris, Stephen Greb, Cortland F. Eble, Sean Bailey
Methane Emissions From Underground Coal Mines, Marcelo Guzman, Thomas Parris, Stephen Greb, Cortland F. Eble, Sean Bailey
Mechanical Engineering Faculty Publications
Methane emissions from Kentucky underground coal mines were measured using near-infrared spectrometers deployed on a vehicle, an airplane, and a small uncrewed aerial system (sUAS), offering insights into the effectiveness of these methods under real-world conditions. From 2021–2022, surveys covered 14 active, 4 inactive, and 4 abandoned mines across Kentucky’s coal-producing basins. Vehicle-based surveys at 13 active mines detected methane anomalies at 9 sites with anomaly lengths spanning tens to hundreds of meters and peak emissions of 665 ± 229 kg h–1 from two Cardinal mine fans. Airborne GHGSat surveys identified anomalies at 3 sites, including a peak of 1062 …
Understanding Desired Greater Collaboration Ties, Seong Won Yang, Giuseppe Labianca, James A. Coutinho, Andrew Pilny, Daniel J. Brass, Carlo J. Labianca
Understanding Desired Greater Collaboration Ties, Seong Won Yang, Giuseppe Labianca, James A. Coutinho, Andrew Pilny, Daniel J. Brass, Carlo J. Labianca
Sociology Faculty Publications
Whereas organizational network studies infer employees’ agentic desires through observed network changes, we capture desires to collaborate more closely with co-workers directly through a survey. We argue that formal structures create workflow dependencies between employees as they gather others’ inputs to complete their tasks, and individuals desire to alter their networks to manage those dependencies using the following two main collaborative approaches: (1) collaborating more intensely with existing formal workflow network partners; and (2) engaging in bypassing approaches with specific partners outside of their prescribed formal workflow. We found that employees pursued a tie-strengthening approach with formal partners they already …
Sacbe 1 And Classic Maya Urban Culture, Traci Ardren, Scott R. Hutson, Travis W. Stanton, Patrick Rohrer, Justin P. Lowry
Sacbe 1 And Classic Maya Urban Culture, Traci Ardren, Scott R. Hutson, Travis W. Stanton, Patrick Rohrer, Justin P. Lowry
Anthropology Faculty Publications
One of the most significant engineering accomplishments of Maya civilization is Sacbe 1, a raised road connecting the ancient urban centers of Yaxuna and Coba. Using new lidar data in concert with excavation, epigraphic inscriptions, and landscape reconnaissance, we show that settlement and an urban experience emanated westward from Coba along the sacbe. The leaders of Coba - in particular, an ambitious seventh-century queen - used the sacbe to expand the political and cultural influence of their dynasty into the center of the peninsula while securing territory and resources. Gaps in the sacbe, precise delineation of its many curves, and …
Intermittent Hypoxemia And Brain Injury Biomarker S100b In Preterm Infants, Elie G. Abu Jawdeh, Linda J. Van Eldik, Jennifer Stevenson, Abhijit Patwardhan, Philip M. Westgate, Lina Chalak, Richard J. Martin, Henrietta S. Bada
Intermittent Hypoxemia And Brain Injury Biomarker S100b In Preterm Infants, Elie G. Abu Jawdeh, Linda J. Van Eldik, Jennifer Stevenson, Abhijit Patwardhan, Philip M. Westgate, Lina Chalak, Richard J. Martin, Henrietta S. Bada
Epidemiology and Environmental Health Faculty Publications
Abstract – Introduction: Intermittent hypoxemia (IH) is common in preterm infants and linked to brain injury. S100B is a glial-derived protein that rises early after neural injury and can be measured noninvasively in urine. We evaluated the relationship between IH burden and urinary S100B in preterm infants of ≤32 weeks’ gestation. Methods: Preterm infants of ≤32 weeks’ gestation were prospectively enrolled. Oxygen saturation was continuously monitored, and IH profiles were quantified using validated algorithms. Urine S100B was measured by ultrasensitive immunoassay and normalized for urinary creatinine. Infants with severe intraventricular hemorrhage were excluded. Weighted Spearman correlations examined associations between IH …
Genetic Modifiers Of Apoe-Ε4-Associated Cognitive Decline, Alex G. Contreras, Skylar Walters, Jaclyn M. Eissman, Derek B. Archer, Alexandra N. Regelson, Alaina Durant, Michelle Clifton, Subhabrata Mukherjee, Michael L. Lee, Seo Eun Choi, Phoebe Scollard, Emily H. Trittschuh, Jesse Mez, William S. Bush, Brian W. Kunkle, Carlos Cruchaga, Adam C. Naj, Katherine A. Gifford, Murat Bilgel, Amanda B. Kuzma, Balebail Ashok Raj, Kristin Fargher, Amanda Smith, Lisa Raudin, Gloria Chaing
Genetic Modifiers Of Apoe-Ε4-Associated Cognitive Decline, Alex G. Contreras, Skylar Walters, Jaclyn M. Eissman, Derek B. Archer, Alexandra N. Regelson, Alaina Durant, Michelle Clifton, Subhabrata Mukherjee, Michael L. Lee, Seo Eun Choi, Phoebe Scollard, Emily H. Trittschuh, Jesse Mez, William S. Bush, Brian W. Kunkle, Carlos Cruchaga, Adam C. Naj, Katherine A. Gifford, Murat Bilgel, Amanda B. Kuzma, Balebail Ashok Raj, Kristin Fargher, Amanda Smith, Lisa Raudin, Gloria Chaing
Epidemiology and Environmental Health Faculty Publications
The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease. However, APOE-ε4 is not deterministic, highlighting the need to identify additional genetic and environmental factors. APOE-ε4 has been linked to accelerated cognitive decline, so we sought to investigate genetic factors that modify APOE-ε4–associated cognitive decline. We conduct cross-ancestry APOE-ε4-stratified and interaction GWAS using harmonized cognitive data from 32,778 participants, including 29,354 non-Hispanic White and 3,424 non-Hispanic Black individuals. Our primary outcome is late-life cognition, measured using harmonized composite scores for memory, executive function, and language, modeled as continuous traits reflecting both normative cognitive aging and disease-related decline. …
Renin-Angiotensin-Aldosterone System In Preeclampsia: Pathophysiological Insights And Links To Vascular Dementia, Robin C. Finch, Jenny Lutshumba, Elizabeth Mirsky, Esther Ndashaala, Kelsey Bullens, Emma Smith
Renin-Angiotensin-Aldosterone System In Preeclampsia: Pathophysiological Insights And Links To Vascular Dementia, Robin C. Finch, Jenny Lutshumba, Elizabeth Mirsky, Esther Ndashaala, Kelsey Bullens, Emma Smith
Pediatrics Faculty Publications
Pre-eclampsia, a condition characterized by new-onset hypertension during pregnancy and one or more indices of organ damage, is a major driver of both short and long-term maternal health outcomes. Individuals with a history of pre-eclampsia are at increased risk for cardiovascular, renal, and other chronic diseases. Recent studies have linked pre-eclampsia history with increased risk of dementia later in life, underscoring the importance of new guidelines emphasizing blood pressure control to reduce the risk of cognitive decline. Unfortunately, neither mechanisms underlying causes of pre-eclampsia nor their links with cognitive function are well understood. Vascular contributions to cognitive impairment and dementia …
Spatial Control Of Myosin Regulatory Light Chain Phosphorylation Modulates Cardiac Thick Filament Mechanosensing, Caterina Squarci, Daniel Koch, Paul Anaya, Kenneth S. Campbell, Thomas Kampourakis
Spatial Control Of Myosin Regulatory Light Chain Phosphorylation Modulates Cardiac Thick Filament Mechanosensing, Caterina Squarci, Daniel Koch, Paul Anaya, Kenneth S. Campbell, Thomas Kampourakis
Physiology Faculty Publications
The heart can adapt its performance in response to changing metabolic demands of the rest of the body. A central mechanism intrinsic to the heart is to modulate the function of the cardiac contractile proteins via posttranslational modifications. Although phosphorylation of the cardiac myosin motor-associated regulatory light chain (RLC) by cardiac myosin light chain kinase (cMLCK) has been recognized as a key signaling pathway to increase myocardial contractile function, little is known about its molecular mechanism of action. Here, we show that phosphorylation of RLC is not a stochastic process but a spatially tightly controlled mechanism in the cardiac sarcomere. …
Duration And Properties Of The Embedded Phase Of Star Formation In 37 Nearby Galaxies From Phangs-Jwst, Lise Ramambason, Mélanie Chevance, Jaeyeon Kim, Francesco Belfiore, J. M. Diederik Kruijssen, Andrea Romanelli, Amirnezam Amiri, Médéric Boquien, Ryan Chown, Daniel A. Dale, Simthembile Dlamini, Oleg V. Egorov, Ivan Gerasimov, Simon C.O. Glover, Kathryn Grasha, Hamid Hassani, Hwihyun Kim, Kathryn Kreckel, Hannah Koziol, Adam K. Leroy, José Eduardo Méndez-Delgado, Justus Neumann, Lukas Neumann, Hsi An Pan, Debosmita Pathak, Karin Sandstrom, Sumit K. Sarbadhicary, Eva Schinnerer, Jiayi Sun, Jessica Sutter, David A. Thilker, Leonardo Ubeda
Duration And Properties Of The Embedded Phase Of Star Formation In 37 Nearby Galaxies From Phangs-Jwst, Lise Ramambason, Mélanie Chevance, Jaeyeon Kim, Francesco Belfiore, J. M. Diederik Kruijssen, Andrea Romanelli, Amirnezam Amiri, Médéric Boquien, Ryan Chown, Daniel A. Dale, Simthembile Dlamini, Oleg V. Egorov, Ivan Gerasimov, Simon C.O. Glover, Kathryn Grasha, Hamid Hassani, Hwihyun Kim, Kathryn Kreckel, Hannah Koziol, Adam K. Leroy, José Eduardo Méndez-Delgado, Justus Neumann, Lukas Neumann, Hsi An Pan, Debosmita Pathak, Karin Sandstrom, Sumit K. Sarbadhicary, Eva Schinnerer, Jiayi Sun, Jessica Sutter, David A. Thilker, Leonardo Ubeda
Physics and Astronomy Faculty Publications
Light reprocessed by dust grains emitting in the infrared enables the study of the physics at play in dusty embedded regions, where ultraviolet and optical wavelengths are attenuated. Infrared telescopes such as JWST have made it possible to study the earliest feedback phases, when stars are shielded by cocoons of gas and dust. Comprehending this phase is crucial for unravelling the effects of feedback from young stars that leads to their emergence and the dispersal of their host molecular clouds. Here we show that the transition from the embedded to the exposed phase of star formation is short (< 4 Myr) and sometimes almost absent (< 1 Myr) across a sample of 37 nearby star-forming galaxies covering a wide range of morphologies, from massive barred spirals to irregular dwarfs. The short duration of the dust-clearing timescales suggests a predominant role of pre-supernova feedback mechanisms in revealing newborn stars, confirming previous results on smaller samples and allowing, for the first time, a statistical analysis of their dependencies. We find that the timescales associated with mid-infrared emission at 21 μm, tracing a dust-embedded feedback phase, are controlled by a complex interplay between giant molecular cloud properties (masses and velocity dispersions) and galaxy morphology. We report relatively longer durations of the embedded phase of star formation in barred spiral galaxies, while this phase is significantly reduced in low-mass irregular dwarf galaxies. We discuss tentative trends with gas-phase metallicity, which may favor faster cloud dispersal at low metallicities.