Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (168)
- Social and Behavioral Sciences (95)
- Medical Specialties (55)
- Life Sciences (48)
- Sociology (48)
-
- Public Health (42)
- Nursing (35)
- Gerontology (34)
- Geriatrics (29)
- Medical Sciences (29)
- Physical Sciences and Mathematics (19)
- Neurology (18)
- Psychology (18)
- Social Work (18)
- Psychiatry and Psychology (17)
- Neuroscience and Neurobiology (14)
- Behavior and Behavior Mechanisms (13)
- Epidemiology (12)
- Statistics and Probability (12)
- Genetics and Genomics (10)
- Critical Care Nursing (9)
- Diseases (9)
- Neurosciences (9)
- Arts and Humanities (8)
- Biostatistics (8)
- Communication (8)
- Education (8)
- Medical Pharmacology (8)
- Mental and Social Health (8)
- Family Practice Nursing (7)
- Keyword
-
- Humans (31)
- Aging (29)
- Male (23)
- Female (21)
- Aged (17)
-
- Dementia (16)
- Animals (14)
- Older adults (13)
- Brain (11)
- Cognition (10)
- Alzheimer Disease (9)
- Older Adults (9)
- Aged, 80 and over (8)
- Middle Aged (8)
- Appalachia (6)
- Caregivers (6)
- Elderly (6)
- Inflammation (6)
- Mice (6)
- Oxidative Stress (6)
- Adult (5)
- Alzheimer's disease (5)
- Alzheimer’s Disease (5)
- Amyloid beta-Peptides (5)
- Down Syndrome (5)
- Education (5)
- Health (5)
- Kentucky (5)
- Nursing (5)
- Signal Transduction (5)
- Publication Year
- Publication
-
- DNP Projects (34)
- Theses and Dissertations--Gerontology (19)
- Sanders-Brown Center on Aging Faculty Publications (12)
- Behavioral Science Faculty Publications (11)
- Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.) (10)
-
- University of Kentucky Doctoral Dissertations (10)
- Graduate Center for Gerontology Faculty Publications (8)
- Pharmacology and Nutritional Sciences Faculty Publications (8)
- DSW Capstone Projects (7)
- Epidemiology and Environmental Health Faculty Publications (7)
- Chemistry Faculty Publications (6)
- MPA/MPP/MPFM Capstone Projects (6)
- Microbiology, Immunology, and Molecular Genetics Faculty Publications (6)
- Social Work Faculty Publications (6)
- Theses and Dissertations--Psychology (6)
- Journal of Appalachian Health (5)
- Neurology Faculty Publications (4)
- Physical Therapy Faculty Publications (4)
- Physiology Faculty Publications (4)
- Internal Medicine Faculty Publications (3)
- Theses and Dissertations--Family Sciences (3)
- Toxicology and Cancer Biology Faculty Publications (3)
- Anthropology Faculty Publications (2)
- Biology Faculty Publications (2)
- Center for Muscle Biology Faculty Publications (2)
- Clinical and Translational Science Faculty Publications (2)
- Family and Community Medicine Faculty Publications (2)
- Kaleidoscope (2)
- Markey Cancer Center Faculty Publications (2)
- Molecular and Cellular Biochemistry Faculty Publications (2)
- Publication Type
Articles 1 - 30 of 255
Full-Text Articles in Entire DC Network
Inflammation Associated With Obesity, Aging, And Amyloid Burden In Adults With Down Syndrome, Victoria L. Fleming-Batayneh, Brian C. Helsel, Lauren T. Ptomey, Benjamin L. Handen, Mark Mapstone, Melissa Petersen, Sharon J. Krinsky-Mchale, Christy L. Hom, Davneet Minhas, Weiquan Luo, Charles Laymon, Joseph H. Lee, Annie Cohen, Beau M. Ances, Adam M. Brickman, Margaret Pulsifer, H. Diana Rosas, Florencia Lai, Shahid H. Zaman, Elizabeth Head, Dana Tudorascu, Julie Price, Fredrick Schmitt, Bradley T. Christian, Ozioma Okonkwo, Sigan L. Hartley, Beau M. Ances, Howard F. Andrews, Karen Bell, Rasmus M. Birn, Adam M. Brickman
Inflammation Associated With Obesity, Aging, And Amyloid Burden In Adults With Down Syndrome, Victoria L. Fleming-Batayneh, Brian C. Helsel, Lauren T. Ptomey, Benjamin L. Handen, Mark Mapstone, Melissa Petersen, Sharon J. Krinsky-Mchale, Christy L. Hom, Davneet Minhas, Weiquan Luo, Charles Laymon, Joseph H. Lee, Annie Cohen, Beau M. Ances, Adam M. Brickman, Margaret Pulsifer, H. Diana Rosas, Florencia Lai, Shahid H. Zaman, Elizabeth Head, Dana Tudorascu, Julie Price, Fredrick Schmitt, Bradley T. Christian, Ozioma Okonkwo, Sigan L. Hartley, Beau M. Ances, Howard F. Andrews, Karen Bell, Rasmus M. Birn, Adam M. Brickman
Neurology Faculty Publications
Objective: Adults with Down syndrome (DS) often show elevated systemic inflammation, but the association with obesity, aging, and Alzheimer's disease (AD) pathology is not well understood. Methods: Data were drawn from 188 nondemented adults with DS participating in the Alzheimer Biomarkers Consortium-DS (ABC-DS). Participants completed clinical assessments, blood draws, and neuroimaging. Plasma biomarkers included indicators of general, pro-, and anti-inflammation. Mixed linear models tested associations between BMI, age, PET-measured amyloid burden, and inflammatory biomarkers, adjusting for sex, trisomy type, and collection site. False discovery rate correction was applied. Results: The majority of the participants met criteria for obesity. Higher BMI …
Provider And Patient Perspectives On The Diagnosis And Treatment Of Alzheimer's Disease, Philippe Amouyel, Sandrine Andrieu, Angela Bradshaw, Ralph C. Carmona, Magali Dumont, Lea Tenenholz Grinberg, Takeshi Iwatsubo, Oskar Hansson, Clifford R. Jack, Gregory A. Jicha, Simin Mahinrad, Eric Mcdade, Catherine J. Mummery, Ronald C. Petersen, Shelagh Robinson, Julie A. Schneider, Lenny Shellcross, Amanda G. Smith, Heather M. Snyder, Beth Tapply, Charlotte Teunissen, Wiesje M. Van Der Flier, Bruno Vellas, David Wallon, Jeff D. Williamson, Donna Wilcock, Maria C. Carrillo
Provider And Patient Perspectives On The Diagnosis And Treatment Of Alzheimer's Disease, Philippe Amouyel, Sandrine Andrieu, Angela Bradshaw, Ralph C. Carmona, Magali Dumont, Lea Tenenholz Grinberg, Takeshi Iwatsubo, Oskar Hansson, Clifford R. Jack, Gregory A. Jicha, Simin Mahinrad, Eric Mcdade, Catherine J. Mummery, Ronald C. Petersen, Shelagh Robinson, Julie A. Schneider, Lenny Shellcross, Amanda G. Smith, Heather M. Snyder, Beth Tapply, Charlotte Teunissen, Wiesje M. Van Der Flier, Bruno Vellas, David Wallon, Jeff D. Williamson, Donna Wilcock, Maria C. Carrillo
Neurology Faculty Publications
Since 2016, the Alzheimer's Association and the Fondation Alzheimer have hosted Global Alzheimer's Leadership Series (GoALS) global think tanks, with world-leading experts for innovative discussions to advance Alzheimer's disease (AD) research and care. The second GoALS think tank, held in June 2024 in Paris, focused on the relationship between biological changes and clinical manifestations of AD in the context of the evolving therapeutic landscape. Discussions spanned real-world experiences of providers, patients, and their families, theoretical considerations, and health system challenges. The lived experience perspective was central to these discussions. The importance of shared decision-making, clear and transparent communication, and the …
Muscle Atrophy After Acl Reconstruction Involves Molecular Mechanisms Beyond Unloading, Alexander R. Keeble, Gonzalez Velez Sara, Nicholas T. Thomas, Allison M. Owen, Austin V. Stone, Darren L. Johnson, Julián Candia, Luigi Ferrucci, Marco Narici, Esther E. Dupont-Versteegden, Brian Noehren, Martino V. Franchi, Christopher S. Fry
Muscle Atrophy After Acl Reconstruction Involves Molecular Mechanisms Beyond Unloading, Alexander R. Keeble, Gonzalez Velez Sara, Nicholas T. Thomas, Allison M. Owen, Austin V. Stone, Darren L. Johnson, Julián Candia, Luigi Ferrucci, Marco Narici, Esther E. Dupont-Versteegden, Brian Noehren, Martino V. Franchi, Christopher S. Fry
Physiology Faculty Publications
Anterior cruciate ligament reconstruction (ACLR) leads to profound muscle atrophy and weakness that remain resistant to rehabilitation. Although early recovery typically involves a brief period of limb unloading, the degree to which disuse alone accounts for muscle pathology after ACLR remains unclear. Here, we leveraged publicly available RNA-seq datasets of muscle biopsies from vastus lateralis obtained 7 days after ACLR or 10 days after unilateral lower limb suspension (ULLS), each with matched control limbs, to directly compare disuse-driven and ACLR-specific early transcriptional responses. Despite similar periods of reduced loading, substantial transcriptomic divergence was identified using both intersection and interaction bioinformatic …
The Association Between Personal Particulate Matter Exposures And Cognitive Function Among Stroke Patients, Kentucky, Usa, Nana Afua Ankomah Dei
The Association Between Personal Particulate Matter Exposures And Cognitive Function Among Stroke Patients, Kentucky, Usa, Nana Afua Ankomah Dei
Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)
Stroke, a major cause of long-term disability and cognitive problems in the U.S., significantly affects people’s quality of life. Exposure to particulate matter (PM2.5) may result in systemic inflammation and oxidative stress, which can worsen the cognitive function of post-thrombectomy stroke patients. This project thus assessed the relationship between PM2.5 exposure and its effect on the cognitive function of post-thrombectomy stroke patients. Fifteen stroke patients (9 non-Appalachian and 6 Appalachian) undergone thrombectomy were recruited. Personal PM2.5 exposure was measured using wearable sensors for a week during the study period. Montreal Cognitive Assessment (MoCA) scores and covariates …
Evaluating The Burnout Mitigating Effects Of A Structured Mentorship Program In Newly Hired Advanced Practice Providers, Melissa Soper
Evaluating The Burnout Mitigating Effects Of A Structured Mentorship Program In Newly Hired Advanced Practice Providers, Melissa Soper
DNP Projects
Importance: Burnout is a leading driver of clinician intent to leave, lower productivity, increased medical errors, and increased resource use.
Objective: The purpose of this project was to evaluate the effects of an evidence-based mentorship program on newly hired advanced practice providers’ (APPs’) level of stress, burnout, and professional fulfillment.
Results: At baseline, APPs demonstrated higher stress levels, moderate professional fulfillment, and low burnout. Outcomes showed improvement at the end of a mentorship program.
Conclusion: Longitudinal studies with larger sample sizes are needed to determine the true effect of a 6-month mentorship intervention on APP burnout, stress, and professional fulfillment.
Adipose Tissue-Derived Small Extracellular Vesicles In Plasma Reveal Molecular Circuitries Underlying Glucose Intolerance, Shalini Mishra, Yixin Su, Ashish Kumar, Sangeeta Singh, Brian S. Finlin, Fang-Chi Hsu, Jingyun Lee, Cristina M. Furdui, Philip A. Kern, Swapan K. Das, Gagan Deep
Adipose Tissue-Derived Small Extracellular Vesicles In Plasma Reveal Molecular Circuitries Underlying Glucose Intolerance, Shalini Mishra, Yixin Su, Ashish Kumar, Sangeeta Singh, Brian S. Finlin, Fang-Chi Hsu, Jingyun Lee, Cristina M. Furdui, Philip A. Kern, Swapan K. Das, Gagan Deep
Internal Medicine Faculty Publications
Objective: Glucose tolerance (GT) is a major effector for adipose tissue (AT) remodeling in obesity, yet its molecular mechanisms remain incompletely defined. We hypothesized that the biophysical and molecular profiles of AT-derived small extracellular vesicles (sEVAT) change in response to glucose availability and differ by GT status.
Methods: sEVAT were isolated from plasma of individuals with normal GT (NGT) and impaired GT (IGT) (n = 5/group) at fasting (0 h) and 1 h post glucose challenge during oral glucose tolerance test (OGTT). sEVAT were characterized for size, concentration, surface expression of insulin receptor-α (INSRα), proteome, …
Resilience Shields And Grit Intensifies Subjective Cognitive Decline In Middle‐To‐Older Aged Black Americans, Sunkanmi Folorunsho, Maria Clark, Obinna Odo, Yolanda L. Jackson, Candidus C. Nwakasi, Darlingtina K. Esiaka
Resilience Shields And Grit Intensifies Subjective Cognitive Decline In Middle‐To‐Older Aged Black Americans, Sunkanmi Folorunsho, Maria Clark, Obinna Odo, Yolanda L. Jackson, Candidus C. Nwakasi, Darlingtina K. Esiaka
Behavioral Science Faculty Publications
Background: There is growing interest on the relationship between psychosocial factors and cognitive health trajectories in adulthood. While grit and resilience have been shown to influence health outcomes, their differential effects on subjective cognitive decline (SCD) in Black American adults remain understudied. The purpose of this study is to help fill this gap.
Methods: The study utilized a cross-sectional research design. Black American participants (N = 242; Mean age = 44.32) responded to a survey assessing SCD, grit, resilience, and sociodemographic factors. Linear regression analysis was performed to test the associations between grit and resilience and SCD, and to …
Chronic Pain And Subjective Memory Problems Are Dynamic Risk Factors For Functional Decline, Tyler R. Bell, Cynthia Felix, Nathalie Gider, George W. Rebok, Michael Crowe, Karlene Ball, Gail Wallace, Sheila Black, Kelsey R. Thomas, Katie M. Wheeler, Felix J. Kollasserry, Jeanine M. Parisi, Caitlin A. Northcutt
Chronic Pain And Subjective Memory Problems Are Dynamic Risk Factors For Functional Decline, Tyler R. Bell, Cynthia Felix, Nathalie Gider, George W. Rebok, Michael Crowe, Karlene Ball, Gail Wallace, Sheila Black, Kelsey R. Thomas, Katie M. Wheeler, Felix J. Kollasserry, Jeanine M. Parisi, Caitlin A. Northcutt
Epidemiology and Environmental Health Faculty Publications
Chronic pain is highly prevalent in older adults and is associated with elevated risk for disability and dementia. Subjective memory problems (SMPs) - self-rated memory difficulties - are also common and may serve as early indicators of functional decline. This study examined associations between SMPs and cognitive, physical, and psychosocial functioning among older adults with and without chronic pain. Data were drawn from 2365 participants in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study. Multilevel models assessed the impact of baseline and time-varying SMPs on cognitive performance (memory, reasoning, processing speed), physical function (mobility, grip strength, self-rated …
Identifying Barriers And Place-Based Solutions To Physical Activity For Older Adults In East Tennessee, Lydia Hoskins, Jodi Southerland
Identifying Barriers And Place-Based Solutions To Physical Activity For Older Adults In East Tennessee, Lydia Hoskins, Jodi Southerland
Journal of Appalachian Health
Introduction: Older adults in East Tennessee (TN), the fastest growing demographic, face significant health challenges, with 44% reporting four or more chronic conditions. The state ranks 45th in physical inactivity among older adults, exacerbating chronic disease risks, fall-related injuries, and mental health issues. Urban-rural disparities in East TN further complicate efforts to promote active living, particularly for rural residents.
Purpose: This qualitative study explored socioecological barriers and solutions to increase physical activity (PA).
Methods: In April 2024, two focus group were conducted in East TN, with a total of 11 participants composed of six community partners and five older adults. …
“Literally Made Me Cry”: The Impact Of Course Material Costs On University Of Kentucky Students, Stephen Krueger
“Literally Made Me Cry”: The Impact Of Course Material Costs On University Of Kentucky Students, Stephen Krueger
Library Reports and White Papers
The Student Course Materials Cost Survey was administered September 16 – October 6, 2024. It was open to current students at the University of Kentucky (UK). The goals were to help UK Libraries better understand how the cost of course materials affects students at UK and to provide a snapshot of student spending across the university. The questions were based on similar research done at other institutions in Virginia (Virginia Course Materials Survey, 2021) and Florida (2022 Student Textbook and Instructional Materials Survey, 2022). Other work based on those surveys includes the 2023 Illinois Course Materials Survey (CARLI, 2023) and …
Who Reconstitutes The Chemotherapy? The Educational And Practice Needs Of Oncology Pharmacists In West Africa: A Call For Multidisciplinary Team Approach In Oncology Care., Runcie C.W. Chidebe, Ramatu M. Alabelewe, Krishna Prasad Sapkota, Darlingtina K. Esiaka, Candidus C. Nwakasi, Gloria C. Okwu, Jacinta Emejulu, Adamu A. Umar, Ndifreke Okwuegbunam, Funsho David, Toyosi Adepoju, Agha A. Agha, Ejike S. Ugwu, Simeon C. Aruah, Richard Mshelia, Rob Duncombe, Noel N. Wannang, Peace C. Babalola, R. Donald Harvey, Cindy O'Bryant, Folakemi T. Odedina
Who Reconstitutes The Chemotherapy? The Educational And Practice Needs Of Oncology Pharmacists In West Africa: A Call For Multidisciplinary Team Approach In Oncology Care., Runcie C.W. Chidebe, Ramatu M. Alabelewe, Krishna Prasad Sapkota, Darlingtina K. Esiaka, Candidus C. Nwakasi, Gloria C. Okwu, Jacinta Emejulu, Adamu A. Umar, Ndifreke Okwuegbunam, Funsho David, Toyosi Adepoju, Agha A. Agha, Ejike S. Ugwu, Simeon C. Aruah, Richard Mshelia, Rob Duncombe, Noel N. Wannang, Peace C. Babalola, R. Donald Harvey, Cindy O'Bryant, Folakemi T. Odedina
Behavioral Science Faculty Publications
PURPOSE: Oncology pharmacists (OPs) play a crucial role in cancer care, treatment, survivorship, and multidisciplinary teams (MDTs). OPs have specialized training in designing, administering, monitoring, and modifying oncology chemotherapy; managing adverse events; and evaluating clinical trials and investigational drugs. Yet, the state of OP has remained largely unknown in the clinical oncology workforce of the West African region. Therefore, this study aimed to understand who reconstitutes chemotherapy and to explain the OP educational and practice needs, challenges, and solutions in Nigeria.
MATERIALS AND METHODS: Using a concurrent embedded mixed method design, 35 OPs completed a questionnaire, and 12 others responded …
Variation In The Potentially Inappropriate Use Of Antipsychotic And Benzodiazepine Medications Among Individuals Receiving Residential Medication Management Reviews, Mouna J. Sawan, Alexander J. Clough, Jodie Hillen, Andrew R. Zullo, Daniela C. Moga, Natalie Soulsby, Danijela Gnjidic
Variation In The Potentially Inappropriate Use Of Antipsychotic And Benzodiazepine Medications Among Individuals Receiving Residential Medication Management Reviews, Mouna J. Sawan, Alexander J. Clough, Jodie Hillen, Andrew R. Zullo, Daniela C. Moga, Natalie Soulsby, Danijela Gnjidic
Epidemiology and Environmental Health Faculty Publications
Objectives To describe the variation in the use of potentially inappropriate antipsychotic and benzodiazepine medications in residents who have received a medication review and to evaluate the extent to which this variation is associated with aged care home (ACH) and resident characteristics. Methods This cross-sectional, retrospective study used pharmacist-extracted data from 15,442 residents across 342 Australian ACHs who had a medication review during 2019. The proportion of residents receiving ≥1 potentially inappropriate antipsychotic and benzodiazepine medication according to Beers criteria were classified into quintiles by facility usage (Q1-Q5). Quintile characteristics were compared using descriptive analysis of facility and resident data. …
Among-Population Variation In Telomere Regulatory Proteins And Their Potential Role As Hidden Drivers Of Intraspecific Variation In Life History, Sarah E. Wolf, Mary J. Woodruff, David A. Chang Van Oordt, Ethan D. Clotfelter, Daniel A. Cristol, Elizabeth P. Derryberry, Stephen M. Ferguson, Mark T. Stanback, Conor C. Taff, Maren N. Vitousek, David F. Westneat, Kimberly A. Rosvall
Among-Population Variation In Telomere Regulatory Proteins And Their Potential Role As Hidden Drivers Of Intraspecific Variation In Life History, Sarah E. Wolf, Mary J. Woodruff, David A. Chang Van Oordt, Ethan D. Clotfelter, Daniel A. Cristol, Elizabeth P. Derryberry, Stephen M. Ferguson, Mark T. Stanback, Conor C. Taff, Maren N. Vitousek, David F. Westneat, Kimberly A. Rosvall
Biology Faculty Publications
Biologists aim to explain patterns of growth, reproduction and ageing that characterize life histories, yet we are just beginning to understand the proximate mechanisms that generate this diversity. Existing research in this area has focused on telomeres but has generally overlooked the telomere's most direct mediator, the shelterin protein complex. Shelterin proteins physically interact with the telomere to shape its shortening and repair. They also regulate metabolism and immune function, suggesting a potential role in life history variation in the wild. However, research on shelterin proteins is uncommon outside of biomolecular work. Intraspecific analyses can play an important role in …
Geographic Patterns Of Human Immunodeficiency Virus (Hiv) Risk Behaviors Among Older Adults: A Strategy For Identifying Space As A Risk Exposure, Laneshia R. Conner, Reuben Adatorwovor, Sarah Jane Robbins, Rujeko O. Machinga-Asaolu, Kathryn Showalter, Carrie B. Oser
Geographic Patterns Of Human Immunodeficiency Virus (Hiv) Risk Behaviors Among Older Adults: A Strategy For Identifying Space As A Risk Exposure, Laneshia R. Conner, Reuben Adatorwovor, Sarah Jane Robbins, Rujeko O. Machinga-Asaolu, Kathryn Showalter, Carrie B. Oser
Social Work Faculty Publications
Objectives: This study examined geographical patterns of HIV risk among adults aged 60 and older.
Methods: The 2019 Behavioral Risk Factor Surveillance System (BRFSS) weighted data was used to analyze self-reported participation in HIV risk behaviors among older adults (n = 62,852). Logistic regression models were used on a dichotomous HIV risk variable to map the distribution of HIV risk behaviors across both census regions and divisions.
Results: The weighted model revealed significance across regions. Across all regions, identifying as female, identifying as Hispanic, and reporting not having depression were protective from participating in HIV risk behaviors.
Discussion: The …
Daily Anxiety And Dual Use Of Cigarettes And Vaping Products: Disparities By Sex, Race, And Ethnicity In U.S. Adults, Maggie K. Richardson, Delvon T. Mattingly, Osayande Agbonlahor, Alison C. Mcleish, Joy L. Hart, Kandi L. Walker
Daily Anxiety And Dual Use Of Cigarettes And Vaping Products: Disparities By Sex, Race, And Ethnicity In U.S. Adults, Maggie K. Richardson, Delvon T. Mattingly, Osayande Agbonlahor, Alison C. Mcleish, Joy L. Hart, Kandi L. Walker
Educational, School, and Counseling Psychology Faculty Publications
Objective:
Despite a decline in cigarette use, the dual use of cigarettes and electronic vaping products (EVPs) is a concerning pattern of nicotine consumption in the United States. Anxiety, a risk factor for tobacco use, may contribute to dual-use patterns; however, the association between daily anxiety symptoms and dual use of cigarettes and EVPs is not known. This study investigated associations between daily anxiety symptoms and dual cigarette and EVP use overall and by sex, race, and ethnicity.
Method:
Data are from the 2020–2022 National Health Interview Survey (n = 83,544). Multinomial logistic regression models, adjusted for sociodemographic factors, …
Examining The Relationship Between Cognitive Auditory Processing And Sex Hormones, Trey A. Cline
Examining The Relationship Between Cognitive Auditory Processing And Sex Hormones, Trey A. Cline
Theses and Dissertations--Gerontology
Estrogen and progesterone have demonstrated modulatory effects on central auditory nervous system (CANS) function. Post-menopausal females often present to audiology clinics with complaints of difficulty hearing in background noise. However, these individuals often have normal peripheral hearing sensitivity on standard audiometry. Previous studies using the auditory brainstem response (ABR) in post-menopausal females demonstrated longer response latencies compared to their premenopausal counterparts, suggesting that sound does not transmit through the CANS as efficiently. However, to date, the available literature focused on sex hormones and the CANS relies mainly on objective measures, predominantly the ABR. The ABR reflects physiologic function through the …
Adverse Childhood Experiences, Depression And Subjective Cognitive Decline By Gender: A Moderated Mediation Analysis, Monique J. Brown, Darlingtina K. Esiaka, Jaya Viswanathan
Adverse Childhood Experiences, Depression And Subjective Cognitive Decline By Gender: A Moderated Mediation Analysis, Monique J. Brown, Darlingtina K. Esiaka, Jaya Viswanathan
Behavioral Science Faculty Publications
Studies assessing depression as a mediating factor between adverse childhood experiences (ACEs) and subjective cognitive decline (SCD) are lacking. Therefore, the aims of this study were to: (1) determine the mediating role of depression in the association between ACEs and SCD; and (2) assess the moderating role of gender. Data were obtained from the 2023 Behavioral Risk Factor Surveillance Study (BRFSS) survey (N = 38,600). Crude and adjusted path analyses were used to determine the mediating role of depression between ACEs and SCD. Adjusted analyses controlled for sociodemographic confounders. ACEs were positively associated with depression (B = 0.129, p …
How Sleep Disorders And Sleep Duration Impact Memory, Alexandria J. Sims
How Sleep Disorders And Sleep Duration Impact Memory, Alexandria J. Sims
Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)
INTRODUCTION: Sleep duration and sleep disorders can cause changes in memory function as populations age. Previous studies have shown that disordered sleep is associated with increased risk of cognitive dysfunction and long and short sleep durations can cause memory impairment. This study studies aims to find if there is an association between sleep disorders and sleep duration and the impacts on memory.
METHODS: In this study, 3,478 participants aged 60 year and older from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 dataset were included in adjusted and unadjusted models, comparing the sleep disorders and sleep duration exposures to …
Plastic Gerontologies: Epigenetic Clocks As Instruments Of The Profitable Medicalization Of Aging, Hans T. Purisch
Plastic Gerontologies: Epigenetic Clocks As Instruments Of The Profitable Medicalization Of Aging, Hans T. Purisch
Theses and Dissertations--Geography
Epigenetic clocks are algorithms that use epigenetic biomarkers of aging to calculate an organism’s ‘biological age.’ Through discursive analysis of commercially available epigenetic clock marketing materials, scientific articles, and interviews with actors in the longevity biotechnology industry, this study examines the commercialization of epigenetic clocks in the form of consumer test-kits. The study argues that longevity biotechnology companies leverage the malleable and fluid qualities of epigenetic markers of biological age to extend the domains of profitable therapies. It shows that epigenetic clock companies market the dynamic qualities of epigenetic biological age measurements to redefine health around the project of optimizing …
The Effect Of A Hospital Community Garden On Healthcare Workers’ Professional Quality Of Life, Madelyn Renee Cline
The Effect Of A Hospital Community Garden On Healthcare Workers’ Professional Quality Of Life, Madelyn Renee Cline
DNP Projects
Background: Healthcare professionals experience a variety of stressors which negatively impact their professional quality of life (ProQOL) potentially leading to increased turnover and nurse shortages in hospitals. There are growing studies addressing ways to improve healthcare ProQOL, yet few have examined the impact of alterations to the workplace on these outcomes.
Purpose: The purpose of this project was to evaluate the effect of a dedicated outdoor green space for nurses during shift breaks on their ProQOL.
Methods: This project used a one-group pretest-posttest design. Data analysis was completed using descriptive and inferential statistics using SPSS software. The Professional Quality of …
Implementation Of A Pilot Post-Code Debrief Tool Initiated By The Chaplains And Unit Lead Nurses Within The Medicine Intensive Care Unit, Sarah Stigall
DNP Projects
Background: Post-code debriefs are shown to improve teamwork and communication, increase performance, and reduce burnout. According to the University of Kentucky HealthCare (UKHC) policy, teams are to perform a post-code debrief immediately after an in-hospital cardiac arrest (IHCA). However, the current policy does not provide guidance on what to include during a debrief session. At UK post-code debrief sessions are documented as occurring 60-72% of the time; however, personal observation and discussions with other bedside and rapid response nurses suggest that post-code debriefs are underperformed when compared to the documentation. Purpose: This study aimed to explore barriers to post-code debriefs …
A Triage Process To Decrease Door To Ekg Times For Adult Patients With Suspected Cardiac Abnormalities In The Emergency Department, Khay Douangdara
A Triage Process To Decrease Door To Ekg Times For Adult Patients With Suspected Cardiac Abnormalities In The Emergency Department, Khay Douangdara
DNP Projects
Objective: The emergency department (ED) triage process for adult patients presenting with suspected cardiac abnormalities should be reliable; however, delays in identifying significant cardiac rhythms can negatively impact patient outcomes. The American Heart Association (AHA) and the American College of Cardiology (ACC) recommend that patients presenting to the ED with cardiac-related concerns undergo an electrocardiogram (EKG) within 10 minutes of arrival. This project aimed to educate ED nurses and implement changes in the triage process to reduce door-to-EKG times for adult patients with suspected cardiac abnormalities.
Methods: This quasi-experimental study utilized a pre- and post-intervention design to evaluate the effectiveness …
Multidimensional Health Outcomes In Lgbtq+ Older Adults In The United States: Individual And Community-Level Protective Factors, Emily P. Lapidus
Multidimensional Health Outcomes In Lgbtq+ Older Adults In The United States: Individual And Community-Level Protective Factors, Emily P. Lapidus
Theses and Dissertations--Psychology
Despite a lifetime of systematic barriers, LGBTQ+ individuals age into late adulthood, likely due to various protective factors. Guided by the Iridescent Life Course Framework (ILCF; Fredriksen-Goldsen & Muraco, 2019), I analyzed unique protective factors at two levels: (1) individual psychological factors (i.e., resilience, identity management) and (2) community-level factors (i.e., LGBTQ+ community connectedness, social support). Health was operationalized as mental health, physical health, and health-promoting behaviors. The present study accounted for covariates (i.e., financial barriers to healthcare, felt subjective age discrepancy, lifetime discrimination). I hypothesized that both stronger individual and community factors would be associated with better physical and …
A Review Of The Association Between Dietary Intake And Brain Iron Levels In Older Adults: Preliminary Findings And Future Directions., Valentinos Zachariou, Christopher E. Bauer, Colleen A. Pappas, Brian T. Gold
A Review Of The Association Between Dietary Intake And Brain Iron Levels In Older Adults: Preliminary Findings And Future Directions., Valentinos Zachariou, Christopher E. Bauer, Colleen A. Pappas, Brian T. Gold
Behavioral Science Faculty Publications
Background/Objectives: Non-heme iron is essential for critical neuronal functions such as ATP generation, synaptogenesis, neurotransmitter synthesis, and myelin formation. However, as non-heme iron accumulates with age, excessive levels can contribute to oxidative stress, potentially disrupting neuronal integrity and contributing to cognitive decline. Despite growing evidence linking high brain iron with poorer cognitive performance, there are currently no proven methods to reduce brain iron accumulation in aging or to protect cognitive function from iron’s negative effects. Recent studies suggest that nutrition may influence brain iron levels, though the evidence remains limited and mixed. Methods: In this review, we explore recent findings, …
Parallel Electrophysiological Abnormalities Due To Covid-19 Infection And To Alzheimer’S Disease And Related Dementia, Yang Jiang, Jennifer Neal, Pradoldej Sompol, Görsev Yener, Xianghong Arakaki, Christopher M. Norris, Francesca R. Farina, Agustin Ibanez, Susanna Lopez, Abdulhakim Al-Ezzi, Voyko Kavcic, Bahar Güntekin, Claudio Babiloni, Mihály Hajós
Parallel Electrophysiological Abnormalities Due To Covid-19 Infection And To Alzheimer’S Disease And Related Dementia, Yang Jiang, Jennifer Neal, Pradoldej Sompol, Görsev Yener, Xianghong Arakaki, Christopher M. Norris, Francesca R. Farina, Agustin Ibanez, Susanna Lopez, Abdulhakim Al-Ezzi, Voyko Kavcic, Bahar Güntekin, Claudio Babiloni, Mihály Hajós
Neurology Faculty Publications
Many coronavirus disease 2019 (COVID-19) positive individuals exhibit abnormal electroencephalographic (EEG) activity reflecting “brain fog” and mild cognitive impairments even months after the acute phase of infection. Resting-state EEG abnormalities include EEG slowing (reduced alpha rhythm; increased slow waves) and epileptiform activity. An expert panel conducted a systematic review to present compelling evidence that cognitive deficits due to COVID-19 and to Alzheimer’s disease and related dementia (ADRD) are driven by overlapping pathologies and neurophysiological abnormalities. EEG abnormalities seen in COVID-19 patients resemble those observed in early stages of neurodegenerative diseases, particularly ADRD. It is proposed that similar EEG abnormalities in …
Mentoring Graduate Students For Academic Careers In Grassland Science, L. E. Sollenberger
Mentoring Graduate Students For Academic Careers In Grassland Science, L. E. Sollenberger
IGC Proceedings (1977-2023)
Effective mentorship enhances student productivity and career achievements, yet faculty generally do not receive mentorship training, nor does mentorship receive focused attention, evaluation, and recognition. The objectives of this paper are to 1) define mentorship and identify roles of a mentor, 2) highlight qualities and outcomes of effective mentoring, and 3) elaborate best mentoring practices, metrics for assessing mentoring, and challenges for mentoring the next generation of grassland scientists. Mentoring is a professional alliance where individuals work together to support the personal and professional growth, development, and success of the relational partners. Mentors should be altruistic discipline experts, have substantial …
Empowering Caregivers In The Prevention Of Clinical Delirium For At Risk Older Adults Boarding In The Emergency Department Setting, Danielle Brewer
Empowering Caregivers In The Prevention Of Clinical Delirium For At Risk Older Adults Boarding In The Emergency Department Setting, Danielle Brewer
DNP Projects
Background: Emergency Department (ED) overcrowding is a global healthcare crisis documented in the literature for more than a decade, impacting patient outcomes and resource availability. While awaiting delayed transfer to an inpatient room, older adults in the ED remain vulnerable to developing acute delirium. Boarding potentiates the risk for worsening health outcomes, which are further compounded by delirium. Scarcity of resources and time constraints delay delirium detection and increase risk for down-stream hospital-acquired complications, higher cost, and prolonged length of stay. Current ED models do not prioritize caregiver partnership or involvement in delirium-conscious care, which is a holistic approach to …
Point Of Care Ultrasound (Pocus) For Advanced Practice Providers (Apps), Crystal S. Rogers
Point Of Care Ultrasound (Pocus) For Advanced Practice Providers (Apps), Crystal S. Rogers
DNP Projects
Background: Advanced practice providers (APPs) routinely lack the skillset to perform Point of Care Ultrasound (POCUS) because currently, there is not a standardized curriculum within scholarly programs (Santos et al., 2018) and/or inadequate hospital training to perform these competencies (Huang et al., 2021). The absence of a standard curriculum has limited the ability of APPs to practice with full scope, provide care that is comparable to physician partners in the acute care setting, and deliver highest quality of patient care. Implementing standard education to train APPs for POCUS addresses this identified gap.
Purpose: The purpose of this project was to …
The Effect Of An Employee Recognition Program For Clinical Registered Nurse Retention At Eastern State Hospital, Kristi Richmond
The Effect Of An Employee Recognition Program For Clinical Registered Nurse Retention At Eastern State Hospital, Kristi Richmond
DNP Projects
Abstract
Background: Nurse executives want to build and retain teams capable of delivering high quality care. However, registered nurse (RN) turnover continues to jeopardize this goal. RN satisfaction has been associated with reduced turnover in the nursing field. Adequate staffing levels are linked to better patient outcomes, and employee recognition is a key factor in RN retention.
Purpose: The purpose of this study was to evaluate the effectiveness of utilizing an existing recognition tool for RNs at an inpatient state psychiatric hospital in the southeastern United States to determine level of job satisfaction, level of job loyalty, level of engagement, …
Implementation Of An Education Intervention Aimed At Intensive Care Unit Providers To Improve Knowledge Of And Screening For Cognitive Impairment Related To Post-Intensive Care Syndrome, Terry Harrod
DNP Projects
Abstract
Background: Post intensive care syndrome is a condition that can lead to a range of physical,
cognitive, and psychiatric issues and is frequently undiagnosed. Educating Nurse Practitioners,
Physician Assistants, and Physician Fellows who work in the ICU about post intensive care
syndrome and a cognitive screening tool like the MoCA can significantly enhance their
understanding and ability to diagnose a component of this syndrome.
Purpose: The purpose of this project was to evaluate the effect of an educational intervention
regarding post intensive care syndrome among ICU nurse practitioners, physician assistants, and
physician fellows treating patients within the ICU.
Methodology: …