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Effects Of Tumor Necrosis Factor-Α On Glucose Metabolism In Cultured Human Muscle Cells From Nondiabetic And Type 2 Diabetic Subjects, Theodore P. Ciaraldi, Leslie Carter, Sunder Mudaliar, Philip A. Kern, Robert R. Henry

Clinical and Translational Science Faculty Publications

The effects of tumor necrosis factor-a (TNFα) on glucose uptake and glycogen synthase (GS) activity were studied in human skeletal muscle cell cultures from nondiabetic and type 2 diabetic subjects. In nondiabetic muscle cells, acute (90-Min) exposure to TNFα (5 ng/ml) stimulated glucose uptake (73 ± 14% increase) to a greater extent than insulin (37 ± 4%; P < 0.02). The acute uptake response to TNFα in diabetic cells (51 ± 6% increase) was also greater than that to insulin (31 ± 3%; P < 0.05). Prolonged (24-h) exposure of nondiabetic muscle cells to TNFα resulted in a further stimulation of uptake (152 ± 31%; P < 0.05), whereas the increase in cells from type 2 diabetics was not significant compared with that in cells receiving acute treatment. After TNFα treatment, the level of glucose transporter-1 protein was elevated in nondiabetic (4.6-fold increase) and type 2 (1.7-fold) cells. Acute TNFα treatment had no effect on the fractional velocity of GS in either nondiabetic or type 2 cells. Prolonged exposure reduced the GS fractional velocity in both nondiabetic and diabetic cells. In summary, both acute and prolonged treatment with TNFα up-regulate glucose uptake activity in cultured human muscle cells, but reduce GS activity. Increased skeletal muscle glucose uptake in conditions of TNFα excess may serve as a compensatory mechanism in the insulin resistance of type 2 diabetes.

Indexed Stems And Russian Word Formation: A Network Morphology Account Of Russian Personal Nouns, Andrew R. Hippisley

Linguistics Faculty Publications

Recent lexeme-based models have proposed that a lexeme carries an inventory of stems on which morphological rules operate. The various stems in the inventory are associated with different morphological rules, of both inflection and derivation. Furthermore, one stem may be selected by more than one rule. For this reason stems in the inventory are labeled with indexes, rather than being directly associated with a particular morphological function. It is claimed that an indexed-stem approach captures generalizations in the morphological system that would otherwise be missed. We argue that such an approach provides for greater generalization in the Russian morphological system. …

Kentucky Lawyer, 1998-1999, University Of Kentucky College Of Law

Annual Magazines

No abstract provided.

Error Estimation Of The Padé Approximation Of Transfer Functions Via The Lanczos Process, Zhaojun Bai, Qiang Ye

Mathematics Faculty Publications

Krylov subspace based moment matching algorithms, such as PVL (Padé approximation Via the Lanczos process), have emerged as popular tools for efficient analyses of the impulse response in a large linear circuit. In this work, a new derivation of the PVL algorithm is presented from the matrix point of view. This approach simplifies the mathematical theory and derivation of the algorithm. Moreover, an explicit formulation of the approximation error of the PVL algorithm is given. With this error expression, one may implement the PVL algorithm that adaptively determines the number of Lanczos steps required to satisfy a prescribed error tolerance. …

Exactly How Much Process Is Due? The Federal Courts Grapple With The Shifting Burdens Of Proof In Civil In Rem Forfeiture Under 21 U.S.C. § 881(A), David A. Cohen

Kentucky Law Journal

No abstract provided.

1998 Highway Cost Allocation Update: Technical Report, Samantha S. Jones, Jerry G. Pigman

Kentucky Transportation Center Research Report

This update of the highway cost allocation study is the eighth in a recent series begun in the early 1980's by the Kentucky Transportation Cabinet and the Kentucky Transportation Center. The primary objectives were to determine the level of revenue contribution and cost responsibility for each class of highway user. The base year of the study is FY 97; the most recent time period for which revenue and cost data were available. Highway user or travel activity for calender year 1996 was the most recent available. A basic premise of the study was that only state maintained highways were of …

Paying For The Health Costs Of Smoking: Loss Shifting And Loss Bearers, Richard C. Ausness

Law Faculty Scholarly Articles

Cigarette smoking is known to cause cancer, heart disease, and respiratory problems. These health costs are enormous, amounting to more than $50 billion per year. Although some of these costs are borne by smokers, many of them are externalized to nonsmokers. Recently, a number of states have sued tobacco companies in or- der to recover the costs of treating smoking-related diseases through their Medicaid programs. At the present time, the parties have agreed to a settlement that obligates the tobacco companies to pay billions of dollars to the states over the next twenty-five years. In other words, some of the …

The Role Of Ethics And Unauthorized Practice Opinions In Regulating The Practice Of Law In Kentucky, William H. Fortune

Law Faculty Scholarly Articles

The purpose of this article is to discuss the role of ethics and unauthorized practice opinions in regulating the practice of law, with suggestions for clarification and improvement.

The Kentucky Bench and Bar, the quarterly journal of the Kentucky Bar Association ("KBA"), prints "Advisory Ethics Opinions" and "Unauthorized Practice Opinions" over the signatures of the respective chairs of the Ethics and Unauthorized Practice of Law ("UPL") Committees. This article describes: 1) how ethics and unauthorized practice opinions are generated; 2) the legal effect of the opinions; 3) the relationship of ethics opinions to attorney discipline; 4) the Board of Bar …

The Theory, Reality, And Pragmatism Of Corporate Governance In Bankruptcy Reorganizations, Christopher W. Frost

Law Faculty Scholarly Articles

Governing a corporation during a Chapter 11 reorganization presents a special case of the age-old problem of the separation of ownership and control. Critics of Chapter 11 have long pointed to the insulation provided by the automatic stay to managers of the business as one of the causes of bankruptcy inefficiency. Protected from the normal contractual and market forces that restrain the behavior of managers of healthy companies, managers of firms in bankruptcy, the harshest critics charge, use delay and other strategies to enrich themselves and the shareholders at the expense of the firm's creditors.

This Article addresses the financial …

In The Belly Of The Beast: A Comparison Of The Evolution And Status Of Prisoners' Rights In The United States And Europe, Roberta M. Harding

Law Faculty Scholarly Articles

Another epidemic has hit the international community. This one, however, is not derived from an unknown bacterial agent. Instead, it originates from a variety of social agents. The epidemic? The explosion in the number of people incarcerated in the global community. As of June 1997, the United States' prison population exceeded 1,700,000. This figure is consistent with the United States' status as one of the world's largest jailers. Like the United States, Europe's prison population has escalated. The growth in France's prison population is representative of the epidemic's trans-Atlantic scope.

The Article is divided into several sections. The first section …

Toward The Proper Role For Mass Tort Class Actions, Mary J. Davis

Law Faculty Scholarly Articles

This Article seeks to advance the use of mass tort class actions and proposes that they are not only appropriate, but desirable, when evaluated against the backdrop of substantive tort law policies. Moreover, the substantive goals of tort law as applied in the mass tort context support the conclusion that the individualized case-by-case adjudication standard, as applied through our adversary system as it is presently constituted, fails to further the search for fairness as well as truth in the mass tort context, and therefore, does not achieve the fairness or justice that we seek through our judicial process.

The guiding …

Kentucky Law Survey: Taxation, Kathryn L. Moore

Law Faculty Scholarly Articles

Certainly the most publicized development in Kentucky tax law during the last five years was the series of decisions in St. Ledger v. Kentucky Revenue Cabinet, striking down two of Kentucky's intangibles taxes. The St. Ledger decisions, however, were not the only tax law development to receive attention.

There were a number of legislative developments of some significance. Specifically, Governor Brereton Jones formed a Tax Policy Commission that comprehensively reviewed Kentucky's tax structure. Although the 1996 General Assembly did not fully embrace the Commission's recommendations over the last five years, the General Assembly did enact some significant legislation. For …

Truck Route Access Evaluation: Fulton County, Hickman Riverport Area, Site No. 16, Lisa Aultman-Hall, Kenneth R. Agent, Brian Aldridge, David Cain, Nikiforos Stamatiadis, Joel M. Weber

Kentucky Transportation Center Research Report

There are two main objectives of the Freight Movement and Intermodal Access in Kentucky Study (SPR 98-189) that is being undertaken by the Kentucky Transportation Center for the Kentucky Transportation Cabinet (KYTC): 1) evaluation of the access for trucks between intermodal or other truck generating sites and the National Highway System (NHS); and 2) furthering the understanding of freight commodity flows throughout the state. This report summarizes the access evaluation for one cluster of facilities located in Fulton county in the Purchase Area Development District (ADD) and KYTC Highway District #1. The location of the site in the town of …

Truck Route Access Evaluation: Medusa Aggregates, Warren County, Site #2628, Brian Aldridge, Kenneth R. Agent, Lisa Aultman-Hall, David Cain, Nikiforos Stamatiadis, Joel M. Weber

Kentucky Transportation Center Research Report

The Freight Movement and Intermodal Access in Kentucky Study (SPR 98-189), undertaken by the Kentucky Transportation Center (KTC) on behalf of the Kentucky Transportation Cabinet (KYTC), has two main objectives. These objectives include the evaluation of access for trucks between intermodal or other truck generating sites and the National Highway System (NHS) and furthering the understanding of freight commodity flows throughout the state. This report summarizes the access evaluation for one facility located in Warren County in the Barren River Area Development District (ADD) and KYTC Highway District #3. The location of the site is shown in Figure 1 while …

Reframing The Affirmative Action Debate, Lani Guinier

Kentucky Law Journal

No abstract provided.

Textualism's Selective Canons Of Statutory Construction: Reinvigorating Individual Liberties, Legislative Authority, And Deference To Executive Agencies, Bradford C. Mank

Kentucky Law Journal

No abstract provided.

Synergy And Friction--The Cra, Bhcs, The Sba, And Community Development Lending, Cassandra Jones Havard

Kentucky Law Journal

No abstract provided.

Fair Use And Educational Copying: A Reexamination Of Princeton University Press V. Michigan Document Services, Inc., Gilbert Busby

Kentucky Law Journal

No abstract provided.

Kentucky Law Survey: Evidence, Robert G. Lawson

Kentucky Law Journal

No abstract provided.

Kentucky Law Survey: Taxation, Kathryn L. Moore

Kentucky Law Journal

No abstract provided.

Kentucky Law Survey: Torts, Ronald L. Green

Kentucky Law Journal

No abstract provided.

Justice Charles M. Leibson And The Revival Of State Constitutional Law: A Microcosm Of A Movement, Jennifer Digiovanni

Kentucky Law Journal

No abstract provided.

St. Ledger V. Kentucky Revenue Cabinet: The Tax That Would Not Die, Rick Alsip, Jennifer Bailey, Melissa Bowman, William G. Fowler Ii, Trey Grayson

Kentucky Law Journal

No abstract provided.

A Lawyer's Guide: How To Avoid Pitfalls When Dealing With Alien Clients, Kelly Kaiser

Kentucky Law Journal

No abstract provided.

The Ubiquitous Yet Illusive "Merger" Clause In Labor Agreements: Semantics, Applications, And Effect On Past Practice, R. Wayne Estes, Kirsten C. Love

Kentucky Law Journal

No abstract provided.

Harris V. Commonwealth: The Use Of "Statutory" Aggravating Circumstances In Kentucky's Sentencing Procedure, Melissa Bartlett

Kentucky Law Journal

No abstract provided.

Personal Jurisdiction And The Internet--Proposed Limits On State Jurisdiction Over Data Communications In Tort Cases, David Wille

Kentucky Law Journal

No abstract provided.

The Duty Of Corporate Directors To Pay Dividends, Randall K. Justice

Kentucky Law Journal

No abstract provided.

The Long Road Towards Restoration Of Religious Freedom: Congressional Options In Light Of City Of Boerne V. Flores, J. Jeffrey Patterson

Kentucky Law Journal

No abstract provided.

The Reemergence Of The Sovereign Immunity Doctrine In Kentucky, Earl F. Hamm Jr.

Kentucky Law Journal

No abstract provided.