Digital Commons Network^™

Maximizing Room-Temperature Red Phosphorescence In Contorted Hexabenzocoronene Derivatives, Marko R. Ivancevic, Moses D. Ogbaje, Jesse A. Wisch, Daniel G. Oblinsky, Alice S. Fergerson, Emily C. Davidson, Gregory D. Scholes, Barry P. Rand, Chad Risko, Quinn C. Burlingame, Yueh Lin Loo

Chemistry Faculty Publications

Organic molecules exhibiting second-scale room-temperature phosphorescence (RTP) in the red/near-infrared are particularly rare because low-energy excited states that are characteristic of these chromophores are susceptible to nonradiative deactivation. Here, we observe second-scale red RTP from contorted hexabenzocoronene (cHBC) embedded in a rigid polymer. This RTP is uniquely efficient as approximately 23% of the steady-state photoluminescence originates from triplets. We propose that this efficient triplet generation stems from intersystem crossing (ISC) that outcompetes symmetry-forbidden fluorescence. Density functional theory and time-dependent density functional theory calculations suggest that ISC occurs from the lowest energy singlet state of cHBC into a nearly resonant triplet …

Endoplasmic Reticulum-Resident Α-Glucosidase Ii Drives Non-Small Cell Lung Cancer Progression Via Regulation Of Secretory Glycoproteins, Shike Wang, Na Ding, Angelo Chen, Derrick Cardin, Yuting Xu, Kate Grimley, William K. Russell, Jun Xu, Jonathan M. Kurie, Guan Yu Xiao, Xiaochao Tan

Markey Cancer Center Faculty Publications

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, yet its molecular drivers are not fully defined. Emerging evidence highlights the importance of tumor-stroma interactions mediated by secreted glycoproteins. However, the mechanisms by which cancer cells regulate the secretion of these protumorigenic proteins remain largely unknown. Endoplasmic reticulum-resident (ER-resident) N-glycan-processing enzymes regulate proper protein folding, a prerequisite for glycoproteins to exit the ER and undergo secretion. By evaluating their prognostic significance in lung tumors and conducting functional screening in lung cancer cells, we identify α-glucosidase II (α-Glc II) as a key regulator of NSCLC progression. α-Glc …

Building And Facility Asset Inventory Assessment And Maintenance, Catherine Keathley, Bethany Paris, Jon Wilcoxson

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) manages approximately 1,500 buildings statewide, including facilities such as office buildings, maintenance and equipment garages, and storage sheds. Because managing buildings and properties requires considerable effort, agency decision makers need reliable monitoring and management tools that generate and organize data which can be used to determine the best course of action for facility maintenance and replacement. In addition to assessing the Cabinet’s building inventory, this report advances recommendations to improve the collection, management, and reporting of facility-related data. Assessment of the inventory managed by KYTC included geolocation of all properties and the buildings therein. Once …

Transportability Analyses In Comparative Effectiveness Research, Blythe Adamson, Wei Liu, Stephen Duffield, Anouk Déruaz-Luyet, Dimitri Bennett, Montse Soriano Gabarró, Mehmet Burcu, Daniela Claudia Moga, Sarah Welby, Tianze Jiao, Xuerong Wen, Grammati Sarri

Epidemiology and Environmental Health Faculty Publications

The Problem: Transportability considerations are increasingly important to answer research questions in comparative effectiveness research (CER) to support the transfer of evidence on medicinal products across countries or settings. As drug development costs rise and healthcare systems and professionals face economic and resource pressures, leveraging existing data and evidence generated across borders or settings can improve efficiency and inform decisions in product development and decision-making (regulatory, health technology assessment [HTA] and clinical care). Differences in population characteristics, healthcare systems, and data availability, including coding discrepancies, may present significant challenges to the transportability of CER evidence. Without rigorous methodological approaches, the …

Kytc Crash Modification Factor Recommendation List Online Tool, William Staats, Reginald Souleyrette, Teng Alex Wang, Mohammad Zana Majidi

Kentucky Transportation Center Research Report

Transportation practitioners use crash modification factors/functions (CMFs) to calculate the number of crashes expected once a countermeasure has been implemented. When evaluating design alternatives, CMFs can be used in conjunction with safety performance functions (SPFs) to derive crash predictions. The Federal Highway Administration (FHWA) maintains the CMF Clearinghouse as a repository for CMFs. Contributions are submitted by researchers across the U.S., Canada, and throughout the world. Typically, individual countermeasures are associated with multiple CMFs. Some CMFs only apply to a specific facility or crash types. CMF quality varies, and some only apply to a specific facility and/or crash types, regions, …

The Polysubstance Assessment Tool, Amanda M. Bunting, Charles M. Cleland, S. Michaela Barratt, Brittany Griffin, Jaimee Williams, Carrie B. Oser, Joshua D. Lee, Jennifer Mcneely

Sociology Faculty Publications

Background and aims: There are currently no brief quantitative assessments that capture the drug patterns of people who engage in use of more than one drug on the same day or simultaneously. The current study examined the retest reliability, acceptability and feasibility of a new quantitative assessment to measure polysubstance use. Design: A tool for assessing simultaneous and same-day polysubstance behaviors, the polysubstance assessment tool (PAT) was developed in interviewer-administered and electronic self-administered formats. Participants were allocated 1:1 to receive either version of the PAT and returned one to three days later to repeat the assessment. Setting: New York City, …

Development Of Kytc’S Context Classification Network, Jill Asher, Megan White, Eric Green, Christopher Van Dyke

Kentucky Transportation Center Research Report

Transportation agencies have adopted context-based classification systems that classify roadways based on the surrounding environment and user types. This offers a more comprehensive and multimodal perspective than traditional functional classification. While the Kentucky Transportation Cabinet (KYTC) has begun using project-level context classification, the agency will benefit from introducing network-level context classification. This will improve guidance, enhance project prioritization, and support the development of projects that better address the needs of all users. Responding to this need, Kentucky Transportation Center (KTC) researchers, in conjunction with KYTC staff, created a GIS-based model to build a context classification network that covers all state-maintained …

The Aurora Survey, Ali Ahmad Khostovan, Ryan L. Sanders, Alice E. Shapley, Michael W. Topping, Naveen A. Reddy, Alex M. Garcia, Danielle A. Berg, Leonardo Clarke, Fergus Cullen, Richard S. Ellis, N. M.Förster Schreiber, Karl Glazebrook, Tucker Jones, Derek J. Mcleod, Anthony J. Pahl, Max Pettini, Paul Torrey

Physics and Astronomy Faculty Publications

We present new constraints on the mass–metallicity (MZR) and fundamental metallicity relations (FMR) using a sample of 34 galaxies at 1.38 ≤ z ≤ 3.5 (median z = 2.28). These galaxies have direct T_e measurements from [O iii]4363 Å and/or [O ii]7320,7331 Å auroral emission lines detected with JWST/NIRSpec as part of the AURORA survey. The detection of both oxygen auroral lines allows for dual-zone direct T_e measurements and expands the dynamic range in (Formula presented) 12+log(O/H)  (7.68–8.65 dex), stellar mass (10⁸–10^10.4 M_⊙), and star formation rate (1–100 M_⊙ yr⁻¹) …

Holographic Description Of 4d Maxwell Theories And Their Code-Based Ensembles, Ahmed Barbar, Anatoly Dymarsky, Alfred Shapere

Physics and Astronomy Faculty Publications

We formulate a precise holographic duality between an ensemble of 4d U(1)^g Maxwell theories living on a spin four-manifold M₄ and a topological Abelian BF-type 2-form theory of level N, summed over all five-manifolds with boundary M₄. The elements of the boundary ensemble are Abelian gauge theories specified by self-dual symplectic codes over ℤ_N, that parameterize topological boundary conditions in the 5d TQFT. Similarly, the equivalence classes of topologies distinguished by the 5d theory are parameterized by orthogonal self-dual codes. Hence the holographic duality can be reformulated in the language of quantum stabilizer codes. …

Missed Clinic Appointments For Human Papillomavirus-Related Oropharyngeal Cancer, John M. Vieth, Anthony A. Mangino, Melina J. Windon, Joseph Valentino

Biostatistics Faculty Publications

Background: Missing appointments delay treatment affecting patient outcomes and healthcare resource utilization. Adherence to scheduled appointments has not been studied in patients with HPV-related oropharyngeal squamous cell carcinoma (HPV-OPSCC). Methods: We collected data from 36,690,000 scheduled medical outpatient encounters at the University of Kentucky Health Care from 2012 to 2021. A total of 36,579 of these encounters were from 334 patients with HPV-OPSCC. We performed regression analysis of no-show appointments by demographics, tumor characteristics, and insurance factors. Results: The no-shows rate for appointments was significantly higher for the HPV-OPSCC cohort (4.6% vs. 2.2% p < 0.001). The HPV-OPSCC cohort missed 36% of their appointments. Black, Hispanic, younger, those who have ever smoked and patients with advanced tumor stage all had statistically significantly higher no-show rates (p < 0.01). Conclusions: Treatment delay impacts cancer treatment efficacy and no-show appointments burden medical systems. Further research into targeted interventions is needed to lower barriers for attending appointments.

From Lineage Discovery To Conservation Prioritisation, Zachary G. Macdonald, Joscha Beninde, Julian R. Dupuis, Thomas W. Gillespie, H. Bradley Shaffer, Gregory F. Grether

Entomology Faculty Publications

Accurate inferences of diversification and evolutionary processes depend on knowing how many independently evolving lineages exist within nominally widespread taxa. Uncertainty in lineage number and composition also limits our ability to meaningfully prioritise conservation efforts. Addressing these knowledge gaps requires frameworks that sequentially identify distinct lineages, assess mechanisms that contribute to their divergence, and quantify spatial and environmental determinants of their genomic diversity. With these goals in mind, we apply whole-genome, ecological, and morphological analyses to the American rubyspot damselfly (Hetaerina americana), a widespread and well-studied North American insect that has been long regarded as a single species of least …

Use Of Function Diagrams In Physiology Education, Thad E. Wilson, Brian A. Jackson, B. Peter Sawaya

Physiology Faculty Publications

Function diagrams focus on physiological concepts rather than associated structures and can serve as elaboration tools and mnemonic aids. A function diagram prototype of the gastrointestinal system was recently described (Wilson TE, Barrett KE. Adv Physiol Educ 45: 264-268, 2021). In this article, a functional diagram of the glomerulus, nephron, urinary system, and bladder is proposed. Colloquially named "Nessie the Nephron" to loosely capture the looping structure and elusive understanding of renal blood flow, glomerular filtration, and epithelial transport for the student, not to mention the nearly mythical countercurrent multiplier. "Navigating the Lochs" references Nessie's possible habitat and more importantly …

Alterations Of Cerebral Extracellular Vesicle Microrna Profiling Potentially Disrupts Brain Homeostasis Following Myocardial Infarction, Md Monowarul Islam, Shouyi Liang, Lijun Sun, Guoku Hu, Neha Dhyani, Lie Gao, Tara L. Rudebush, Xue Xu, Jinpeng Liu, Irving H. Zucker, Changhai Tian

Markey Cancer Center Faculty Publications

Cognitive impairment (CI) is prevalent among heart failure (HF) patients. Although the brain injury in HF is multifactorial, oxidative stress and neuroinflammation are common pathological features of neurological disorders and are increasingly recognized as key mechanisms underlying CI. Extracellular vesicles (EVs) are well-established mediators of biological signaling in myocardial function and are widely recognized for transporting a variety of microRNAs. However, whether myocardial injury alters the miRNA profiles of brain EVs, potentially contributing to cognitive impairment (CI) by disrupting brain homeostasis, remains poorly understood. Using a rodent myocardial infarction (MI) model, we isolated brain EVs and characterized their miRNA profiling …

Cardioprotective Effects Of 1,3 Butanediol In Masld Via Reversal Of Cardiac Lipid Accumulation And Suppression Of Cardiac Fibrosis, Olufunto O. Badmus, Landon D. Parrow, Karis E. Mcgowen, La Brenda Bell, Jennifer R. Greer, Marcela De Carvalho Cruz, Terry D. Hinds, David E. Stec

Markey Cancer Center Faculty Publications

Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly associated with the development of cardiovascular disease (CVD); however, the mechanisms responsible are currently unknown. We have developed a model of MASLD due to the loss of hepatocyte peroxisome proliferator-activated receptor α (PPARα^HEPKO). We found that plasma beta-hydroxybutyrate (BHOB) levels were significantly reduced in PPARα^HEPKO mice and aimed to investigate the therapeutic potential of restoring BHOB levels in the development of CVD in these mice. Thirty-week-old PPARα^HEPKO and control PPARα^FL/FL mice were randomized to receive 1,3 butanediol (1,3-BDO), a precursor of BHOB, in drinking water for 6 …

Chemical Structure Representation Standardization Is Needed To Generalize Metabolite-Pathway Involvement Prediction Across Kegg, Reactome, And Metacyc Knowledgebases, Erik D. Huckvale, Hunter N.B. Moseley

Markey Cancer Center Faculty Publications

Background/Objectives: Due to the utility of knowing the pathway involvement of metabolites detected in biological experiments, knowledgebases such as the Kyoto Encyclopedia of Genes and Genomes (KEGG), Reactome, and MetaCyc have annotated compound entries to specific pathways defined by the knowledgebase. However, these compound-pathway annotations are largely incomplete and are costly to obtain experimentally or curate from published scientific literature. This metabolite-pathway annotation incompleteness problem is amenable to machine learning (ML)-based solutions. But to date, no machine learning model has been trained on all three knowledgebases to maximize its performance and robustness. This may be due to inconsistencies in chemical …

In Situ Molecular Organization And Heterogeneity Of The Legionella Dot/Icm T4ss, Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen

Markey Cancer Center Faculty Publications

The Dot/Icm type IV secretion system (T4SS) is essential for Legionella pneumophila infection, but its in situ architecture and mechanism remain incompletely understood. Using cryo-electron tomography, we performed subtomogram averaging and 3D classification to resolve structural heterogeneity within the complex. We identified multiple assembly states of the inner membrane complex, including a fully assembled form with a hexamer-of-dimers DotO ATPase and symmetry mismatches between subcomplexes. A composite in situ model revealed a central channel above the inner membrane, likely used for substrate secretion. Imaging of infected macrophages showed T4SSs tethered to host vacuoles and extracellular vesicle release, suggesting additional effector …

Weaning Stress Induced Alterations To The Hypothalamic-Pituitary-Thyroid And -Adrenal Axes In Swine, Isabel B. Walpole, Alyssa A. Smith, Kaylyn G. Rudy, Dayeon Jeon, J. Scott Radcliffe, J. Alex Pasternak

Animal and Food Sciences Faculty Publications

Combined modulation of the hypothalamic–pituitary–thyroid (HPT) and hypothalamic–pituitary–adrenal (HPA) axes is known to play a critical role in maintaining physiological stability in response to stress. In this study, stress induced modulation of these axes was examined using 20 pigs/treatment either weaned (WN), weaned with feed/water restriction 9 h (FR), transported 9 h (TRANS), or remaining with sow (SOS) and euthanized at 32 or 56 h post-weaning. Serum cortisol, thyroxine (T4), and triiodothyronine (T3) were measured before weaning and after 24, 32, and 56 h with no difference in cortisol concentrations among treatments at any timepoint. However, both T3 and T4 …

Soil Nutrient Constraint For Legume-Based Pastures In The Brazilian Cerrados, W Couto, C Sanzonowics

IGC Proceedings (1977-2023)

Soil-nutrient deficiencies in two cerrados soils have been investigated as a preliminary to small-plot research oriented to estimate fertilizer requirements for establishment of legumes in grass-legume associations. The studies were conducted in the greenhouse, in 2-kg pots, with surface-soil samples taken from two sites representative of the dominant soils in the region. These are the dark red latoso1 (DRL) and the red-yellow latosol (RYL), which qualify as Haplustox and Acrusto:,:, respectively. Two kinds of e:,:periments were carried out. One consisted of a 1/4 replicate of a 28 factorial including potassium (K), calcium (Ca), magnesium (Mg), sulfur (S), zinc (Zn), molybdenum …

Phytotoxic Response Of Five Range-Grass Species To Six In-Situ Fossil-Fuel Retort Waters, O D. Skinner, J C. Sexton, T S. Moore, D S. Farrier

IGC Proceedings (1977-2023)

Oil shale, tar sands, and undergrowid coal gasification represent viable sources of fossil fuel to assist in meeting U.S. energy needs. Development of fossil-fuel-processing technologies has progressed to a point where commercialization may soon become a reality. Concurrent with this development must be the assessment and solution of environmental problems. A particular and significant problem resides in the handling, containment, treatment, disposal, use, and eventual fate of waters recovered with the oil, gas, and subsurface waters associated with synfuel-processing techniques. The magnitude of plant responses and poten­tial phytotoxic effects resulting from exposure to these produced waters have not been evaluated, …

Liming For Tropical Legume Establishment And Production, G H. Snyder, A E. Kretschmer Jr

IGC Proceedings (1977-2023)

Liming has been declared unnecessary for tropical legume production because tropical legumes (1) are efficient in extracting Ca from soils and are tolerant of excess Al, Fe, and Mn, and (2) are readily nodulated by alkali-producing Rhizobium that can function in acid soils. Numerous research reports from Australia, Uganda, Brazil, and Colombia lend credence to this thinking, since no lime responses were observed in those studies. In other work, liming actually depressed tropical legume growth. However, positive responses have been reported in Australia, Hawaii, and Brazil. In Florida, we have observed considerable improvement in the production of Siratro (Macroptilium atropurpureum …

White Clover: An Olde Crop With A Promising Future, P B. Gibson, W E. Knight, G W. Barnett, W A. Cope, J D. Miller

IGC Proceedings (1977-2023)

White clover (Trifolium repens L.) is a widely adapted, important forage legume for grazing in the U.S. The palatability and quality of the forage, the wide adaptation of the plants to growth in different climates and under various grazing conditions and the role it plays in supplying nitrogen to pastures make white clover our finest pasture legume. The use of adapted white clover cultivars should result in large economic gains to the livestock industry in the U.S .A. Beef and dairy farmers would profit from reduced need for nitrogen fertilizer, an extended grazing season, increased forage pro­duction and quality, better …

Preliminary Evaluation Of Legume Germ Plasm In The Cerrados Of Brazil, D Thomas, R P. De Andrade

IGC Proceedings (1977-2023)

In 1978 an evaluation program was initiated to select legumes that (1) grow and produce seed on acid soils under aluminum and water stress, (2) persist under grazing, and (3) tolerate pests and diseases. The work is being conducted at the Cerrados Agricultural Research Center, near Brasilia, at lat 15°S and altitude 1,000 to 1, 100 m . Annual rainfall is 1,500 mm, mostly distributed in a 6-month wet season, and mean annual temperature is 21°C. Nine hundred legume accessions from thirteen genera have now been established as spaced plants on the 2 major soil types of the region. The …

An Ice-Sheet Modelling Framework To Determine Vulnerable Regions Of The Greenland Ice Sheet In The Past, Benjamin A. Keisling, Joerg M. Schaefer, Robert M. Deconto, Jason P. Briner, Nicolás E. Young, Caleb K. Walcott-George, Gisela Winckler, Allie Balter-Kennedy, Sridhar Anandakrishnan

Earth and Environmental Sciences Faculty Publications

The contribution of the Greenland Ice Sheet (GrIS) to sea-level rise is accelerating and there is an urgent need to characterize which sectors of the ice sheet are the most vulnerable. Estimating the volume of Greenland ice that was lost during past warm periods can support efforts to constrain the ice sheet's response to future warming. Sub-ice sediment and bedrock, retrieved from deep ice core campaigns or targeted drilling efforts, yield critical and direct information about past ice-free conditions. However, it is challenging to scale the few available sub-ice point measurements to the geometry of the entire ice sheet. Here, …

Assessing Legacy Collections: Analyzing The Preservation, Recovery, And Interpretive Value Of Archaeobotanical Remains From Site 15le70 (Pine Crest Rockshelter), Lee County, Kentucky, Jennifer Carroll

Graduate Final Projects

This paper uses the archaeobotanical assemblage from Site 15Le70, a multi-excavated and extensively looted rockshelter in eastern Kentucky, while opening new lines of inquiry into gendered labor and practice during the Archaic-Woodland transition. Because legacy collections are often dispersed across institutions and/or research projects, the materials from any single site may be fragmented, as was the case for 15Le70. Such collections can be overlooked, yet this investigation into 15Le70’s archaeobotanical assemblage demonstrates that partial or scattered datasets can yield meaningful results and hold the potential to fill gaps in the archaeological record left by looting.

In this study, a small …

Elevated Plasma Cholesterol Improves Sepsis Outcome By Promoting Hepatic Metabolic Reprogramming, Qian Wang, Jianyao Xue, Ling Guo, Dan Hao, Misa Ito, Rianna Reese, Bin Huang, Congqing Wu, Xiang An Li

Markey Cancer Center Faculty Publications

Background – Sepsis is a life-threatening condition with high mortality and limited therapeutic options. This study investigated the association between plasma cholesterol levels and sepsis survival and explored the mechanisms by which elevated cholesterol confers protection. Methods – We analyzed 2, 787 sepsis patients from the MIMIC-IV database, comparing cholesterol levels between 28-day survivors and non-survivors and assessing mortality risk using multivariable Cox regression. To test causality, C57BL/6J mice were fed either a high-cholesterol diet (HCD) or a regular diet (RD) before cecal ligation and puncture (CLP). Results – Survivors had significantly higher cholesterol than non-survivors (median 135 vs. 126 …

Maternal Opioid Use And Hepatitis C Infection Disrupt The Placental Immune Landscape And Structure, Heather E. True, Brianna M. Doratt, Sheridan B. Wagner, Delphine C. Malherbe, Nathan R. Shelman, Mahdi Eskandarian Boroujeni, Cynthia Cockerham, John M. O'Brien, Ilhem Messaoudi

Markey Cancer Center Faculty Publications

Maternal opioid use disorder (OUD) poses substantial risks to maternal and fetal health. These adverse outcomes are believed to be mediated, in part, by changes in placental structure and function; however, few studies have addressed this question. Here, we utilized flow cytometry, histology, and spatial and single-cell transcriptomics to uncover the impact of OUD on placental tissues. Given that half of individuals with chronic OUD contract hepatitis C (HCV), we further stratified our findings by maternal HCV status. Our results indicate that OUD leads to higher incidence of vascular malperfusion accompanied by increased levels of inflammatory markers and dysregulated secretion …

Integrating Advanced Geochemical Workflows With Modern Statistical Tools To Improve The Decision-Making Process At Ccr Sites, A Case Study, Glenna Thomas

World of Coal Ash Proceedings

While statistical assessment provides the foundation for CCR compliance reporting, incorporating a holistic geochemical framework transforms statistics from a compliance requirement into a powerful predictive tool. Strategic geochemical insight established the basis of understanding needed to support successful statistical approaches and to ensure that statistical outcomes reflect actual groundwater behavior. Whether it is trend analysis, delineating source mechanism, or updating geochemical conceptual site models (GCMs), geochemical context provides the technical foundations for statistical outputs and methods. A continuously refined GCSM enhances the ability to anticipate how groundwater chemistry should evolve, improving interpretation and predictive capability. This allows practitioners to understand …

Before The Limit Hits: Lessons From A Proactive Construction Air Monitoring Program, Brian Egan, Nicholas Golden, Wendy Depp

World of Coal Ash Proceedings

This presentation describes a comprehensive air monitoring program designed to protect workers and nearby neighborhoods during ash pond closure work. The program uses three main components: project (or boundary) monitoring at the site perimeter to track dust near the project boundaries, work area monitoring placed near active construction zones, and personal sampling on individual workers at regular intervals. Together, these approaches provide data on both community impacts and worker exposures, helping the team respond quickly when levels approach action limits. The Teams actions prior to exceedance of regulatory limits has helped prevent exposures. The talk will explain how monitors are …

Monitored Natural Attenuation Evaluation And Additional Characterization Of A Ccr Unit Lithium Groundwater Plume, Matt Barickman, Adam Piestrzeniewicz Pg

World of Coal Ash Proceedings

Monitored Natural Attenuation (MNA) refers to the reliance on natural attenuation processes (within the context of a carefully controlled and monitored site cleanup approach) to meet groundwater protection standards (GPS) for a CCR unit within a reasonable time frame (USEPA, 1999). MNA is being evaluated as an adaptive management strategy for a CCR unit groundwater plume with statistically significant lithium concentrations above GPS, though with little risk of offsite migration. A previous MNA evaluation was performed for the lithium plume following the United States Environmental Protection Agency (USEPA) “tiered lines of evidence approach” (USEPA, 2015), which determined that there were …

Establishing Groundwater Monitoring Systems Under The Legacy Rule: A Systematic Approach For Utilities, Chris Hoglund

World of Coal Ash Proceedings

The USEPA’s Legacy CCR Rule introduces new requirements for establishing groundwater monitoring systems at Legacy Surface Impoundments (LSIs) and Coal Combustion Residual Management Units (CCRMUs). These requirements present unique challenges for electric utilities, particularly at inactive or historically operated facilities where subsurface data are limited and CCR units may have nontraditional configurations such as linear roadways, elongated embankments, or distributed disposal areas. Utilities must also determine how best to apply single-unit or multi-unit monitoring approaches, integrate newly regulated units into existing monitoring networks, and align monitoring system design with planned closure strategies. This presentation outlines a systematic, defensible framework to …