Digital Commons Network^™

Evaluation Of Middle School Teachers Knowledge, Attitudes, And Barriers Pertaining To Adapted Youth Mental Health First Aid For Middle School Students, Lauren Hurley

DNP Projects

Background: An estimated 17.1 million youth have experienced a mental health disorder, more than the number of children with cancer, diabetes, and AIDS combined (National Council for Behavioral Health, 2016). Unfortunately, of those children with a diagnosable condition, only a third receive mental health treatment (National Council for Behavioral Health, 2016). If a child or adolescent’s mental health disorder is left untreated, then unresolved issues may continue to affect them as adults, creating physical and mental health impairments, that could potentially have a negative impact on their futures. Youth Mental Health First Aid (YMHFA) is an evidenced-based training program that …

Promotion Of Early Recognition Of Depression To Improve Health Related Quality Of Life In Pediatric Oncology Patients, Jennifer Blankenship

DNP Projects

Background: Depression and anxiety are serious complications of cancer and deemed a challenging diagnosis due to the symptoms of depression mimicking common side effects of chemotherapy and radiation. Signs/symptoms frequently are underrecognized thus appropriate treatment is delayed, compromising the health-related quality of life (HRQOL) for pediatric oncology patients.

Purpose: Analyze existing physician and Advanced Practice Provider (APP) clinical practice regarding depression, via a pre- and post-survey and educational PowerPoint on the use of the Center for Epidemiological Studies Depression Scale for Children (CES-DC) to promote early recognition of depression.

Methods: A prospective, single-arm, study was completed in the Kentucky Children’s …

Increasing Confidence Of Nurses In Giving And Receiving Constructive Performance Feedback, Savanna Carroll

DNP Projects

Background: Nursing peer review is a process of reviewing standard nursing practice in an organization and comparing a nurse’s own practice to that standard. Nursing peer review contributes to the professional practice environment by assuring standard practice and competence, maintaining a culture of accountability, and maintaining psychological safety.

Purpose: The purpose of this project was to design and implement an educational intervention and simulation activity to prepare nurses to have constructive conversations with peers regarding work performance. Evaluation of the intervention would yield increased confidence and competence of nursing staff in giving constructive performance peer feedback.

Conceptual Framework: Bandura’s Social …

The Site Evaluation Of Quercus Alba Metabolites, Zachary Alexander Byrd

Theses and Dissertations--Plant and Soil Sciences

Quercus alba has been the prominent tree species utilized in the spirits industry for decades. Of its many qualities, the ability to impart desirable flavors on spirits combined with its natural abundance makes it the ideal choice for barrels. Creating barrels is a uniform process, but variability still exists in aged spirits even when all other parameters are controlled. In this thesis, I explore how the origin of Quercus alba influences metabolite variability.

Quercus alba is a resilient species that can grow in many climates. This is seen through Quercus alba’s vast growing range, of which barrel quality white oak …

Derivation, Exploration And Evaluation Of Non-Equiatomic High Entropy Alloys, Artashes Ter-Isahakyan

Theses and Dissertations--Chemical and Materials Engineering

High-entropy alloys (HEAs) are a class of multicomponent alloys based on an innovative alloying strategy that employs multi-principle elements in relatively high concentrations. Commonly defined as alloys that contain at least five principal elements, each with a concentration between 5 and 35 at %. The term entropy refers to the excess configurational entropy associated with HEAs, which is thought to facilitate the formation of solid solutions. The design strategy results in vast compositional space for exploration and innovative potential triggering a renaissance in physical metallurgy. These alloys may have favorable properties compared to conventional dilute solid solutions, but their preeminent …

Black Youth Are Suffering In Silence: Advancing Social Work Education To Better Address The Mental Health Of African American Youth., Alicia Dawson

DSW Capstone Projects

African American youth’s rates of major depression, generalized anxiety disorder, post-traumatic stress disorder, and suicide have increased in the last three years due to COVID-19 and national social injustices. African American students who seek help at school are less likely to receive adequate treatment from school social workers. Mental health care for African American students should be available, and those services must be effective. African American youth continue to suffer in silence when school social workers lack African-centered conceptual teaching and therapeutic skills. Current social work education curriculums contribute to 'Whiteness,' which influences future social workers to carry biases and …

Oxidative Damage To Brain Cells Underlies: (I) Resistance To Radiation And Increased Tumor Cell Growth In Glioblastoma; (Ii) Apoe Allele Status And Pentose Phosphate Pathway Proteins In Alzheimer Disease Mouse Models, Nicole Rummel

Theses and Dissertations--Chemistry

Oxidative phosphorylation occurs within the inner mitochondrial membrane producing ATP for the cell’s energy needs. The Electron Transport Chain carries out the transfer of electrons from electron carriers through a series of proteins to form a proton gradient across the inner mitochondrial membrane. This gradient acts as the energy source needed to put a phosphate onto ADP and form ATP. With the large amounts of free electrons and oxygen within the mitochondria, an inevitable by-product of free radicals in the form of superoxide are produced. Superoxide (O^-̇₂) is a reactive radical that can react further to …

Synthesis Of 6,6- And 7,7-Difluoro-1-Acetamidopyrrolizidines And Their Oxidation Catalyzed By The Nonheme Fe Oxygenase Lolo, Nabin Panth

Theses and Dissertations--Chemistry

One of the remarkable steps in loline alkaloid biosynthesis is the installation of an ether bridge between two unactivated C atoms in 1-exo-acetamidopyrrolizidine (AcAP). LolO, a 2-oxoglutarate-dependent nonheme Fe oxygenase, catalyzes both the hydroxylation of AcAP and the resulting alcohol's cycloetherification to give N-acetylnornoline (NANL). The mechanism of hydroxylation is well understood, but the mechanism of the oxacyclization is not. I synthesized difluorinated analogs of AcAP in an attempt to further understand the mechanism of the unusual cycloetherification step.

I prepared 6,6-F₂-AcAP in eight steps from N,O-protected 4-oxoproline. The key step was a Dieckmann …

Mass Spectrometric Analysis Of Lignin Model Compounds: Fundamental Investigations Of Ionization And Supramolecular Interactions For Lignocellulosic Biomass Applications, Kimberly Dean

Theses and Dissertations--Chemistry

Lignocellulosic biomass is pivotal for the development of renewable energy sources and materials essential to mitigate the exploitation of fossil fuels causing climate change and environmental pollution issues. The conversion of biomass into fuel requires the hydrolysis of cellulose and a biproduct of this process is the isolation of millions of tons of lignin as biorefinery waste. Lignin is a complex high molecular weight polymer whose structure remains undefined and critically limits potential industrial applications of lignocellulosic biomass. The advancement of analytical methods for structural elucidation of lignin and its ensemble of phenolic compounds is therefore essential to advance this …

The Role Of Charge On Dna Packaging And Integrity Within Reconstituted Peptide-Dna Assemblies, Ehigbai Oikeh

Theses and Dissertations--Chemistry

In nature, DNA exists primarily in a highly compacted form. The compaction of DNA in vivo is mediated by cationic proteins; histone in somatic nuclei and arginine-rich peptides called protamines in sperm chromatin. The packaging in the sperm nucleus is significantly higher than somatic nuclei resulting in a final volume roughly 1/20^th that of a somatic nucleus. This tight packaging results in a near crystalline packaging of the DNA helices. While the dense packaging of DNA in sperm nuclei is considered essential for both efficient genetic delivery as well as DNA protection against damage by mutagens and oxidative species, …

Synthesis And In Situ Characterization Of Intercalated Transition Metal Oxide Nanomaterials Investigated For Novel Cathode Applications, Ahamed Ullah

Theses and Dissertations--Chemistry

To develop an effective battery cathode material that can be useful for future batteries, the thermal stability and ion diffusion dynamics need to be well understood. In situ transmission electron microscopy (TEM) is a popular and proven technique to study the evolution of local structures during the dynamic processes in the cathode materials. This dissertation will demonstrate the application of high-resolution imaging and in situ heating and biasing in the TEM to study the structure and composition, morphology change, and ion diffusion in the cathode materials.

The three chapters in this dissertation will be focused on the two cathode materials: …

Antibiotic Permeation In Gram-Negative Bacteria And Contribution Of Inflammasome Activation And Pyroptosis In Pathogenesis Of Salmonella Systemic Infection, Ankit Pandeya

Theses and Dissertations--Chemistry

Antibiotic resistance is one of the major global issues in the field of public health and medicine. Good antibiotic candidates need to be selectively toxic, inhibit cellular target, and effectively penetrate and accumulate in bacterial cells. The last factor is a formidable barrier in the development of antimicrobials effective in Gram-negative bacteria, due to the presence of two layers of cell envelope. The first half of my thesis focuses on understanding the permeation of small molecules through this formidable cell envelope, distribution inside the cell of Gram-negative bacteria, and design of novel methods to make small molecules effectively cross the …

Succinylated Polyethylenimine Gene Delivery Agents For Enhanced Transfection Efficacy, Md. Nasir Uddin

Theses and Dissertations--Chemistry

Gene therapy aims to treat patients by altering or controlling gene expression. Today, most clinical approaches are viral-based due to their inherent gene delivery activity. However, there is still a significant interest in nonviral alternatives for gene delivery, particularly synthetic lipids and polymers, that do not suffer the immunogenicity, high cost, or mutagenesis concerns of viral vectors. Polymeric vectors are of particular interest due to the ability to further tune the polymer properties through the incorporation of additional functional units such as targeting ligands or shielding domains. Polyethylenimine (PEI), a highly cationic polymer, is often considered a benchmark for polymer-based …

The Design And Synthesis Of New Organic Dithiols For Environmental Applications, Shashika Nadishani Bandara

Theses and Dissertations--Chemistry

A thiol molecule, 2,6-pyridinediamidoethanethiol (PB9), was synthesized based on the pyridine-2,6-dicarboxamide scaffold with appended cysteamine groups. PB9 acts as an effective chelator for Pb(II) due to multiple binding sites (N₃S₂) through irreversible binding precipitating Pb(II). Removal of aqueous Pb(II) from solution was demonstrated by exploring the effects of time, initial PB9:Pb(II) ratios, pH, exposure time, and solution temperature. After 15 min the Pb(II) concentrations were reduced from 50.00 ppm to 0.30 ppm (99.4%) and 0.25 ppm (99.5%) for PB9:Pb ratios of 1:1 and 2:1, respectively. Removal of > 93% Pb(II) was observed over multiple pH values with …

Cell-Engineered Vesicles For Therapeutic Delivery And Immunomodulatory Applications, Khaga Neupane

Theses and Dissertations--Chemistry

Development of a new kind of drug delivery system (DDS) that could efficiently deliver therapeutics to the cell of interest would allow us to accomplish cell-specific drug delivery while eliminating systemic toxicity. Although nanocarriers including endogenously released extracellular vesicles (EEVs), liposomes, and small molecules seem to be promising drug delivery systems, biological challenges persist for their use in clinical applications. Here, we demonstrate nanovesicles engineered by fragmenting cellular membranes can be exploited as versatile DDSs for therapeutics delivery as well as immunomodulatory functions. Cell-engineered vesicles were produced by cavitating cells using nitrogen gas at high pressure followed by serial centrifugation. …

The Role Of Organizational Leaders In Employee Self-Care: A Change Management Approach, Olivia Dawn Honaker

DSW Capstone Projects

Although literature demonstrates that helping professionals have had high levels of stress and burnout for decades, the COVID-19 pandemic has only exacerbated the issue. The already burdened healthcare workers, now facing increased workloads, long hours, and high-level exposure to trauma, have created an urgency to address this significant risk to helping professionals. The current capstone will bring awareness to organizational leaders regarding the importance of employee self-care and the benefits of implementing employee self-care programs. First, a systematic literature review will examine self-care in helping professions and explore how organizational leaders operationalize employee self-care programs. In addition, the capstone aims …

Meta-Practice For The Bachelor Level: A Needed Compliment To The Generalist Model, Patrick Callahan

DSW Capstone Projects

Meta-practice in this concept is the web or roadmap, that is, the interconnectedness of the three pillars of the generalist model of social work. The generalist model teaches that micro, mezzo, and macro are interconnected. However, students and new professionals often do not understand precisely what the connection is. This work gathers the available literature, the conceptual idea of the introduction for the bachelor level of education, and an application of introducing it in a course for instruction. There is a need for introducing meta-practice at the bachelor’s level because of the continued globalization of society. By teaching the concept …

Defining Posttraumatic Stress In Law Enforcement: Normalizing Trauma Response, Britta D. Caudill

DSW Capstone Projects

Significant inequalities exist within the expectations of police officers regarding trauma exposure and the lack of mental health preventive efforts and treatment opportunities. The prevalence of stigma thrives within the thought process of this culture paired with the expectation for resiliency, as police culture focuses on the ability to repress emotion instead of utilizing appropriate coping methods. This review takes an interesting look at the history, definition, and diagnostic criteria of post-traumatic stress disorder (PTSD) by focusing on its evolution within the Diagnostic and Statistical Manual (DSM) over time. The primary goal is to establish a relationship between the definition …

Good Trouble: Disrupting The Disproportionality Of Black Boys In Special Education Due To Misdiagnosed And Unaddressed Trauma, Montrell Pryor

DSW Capstone Projects

Black boys experience a myriad of trauma as they navigate through society under the gaze of white patriarchy and archetypes. Whether engaging in trauma or witnessing it, it impacts Black boys tremendously, particularly in the educational setting. What typically looks like misbehavior in the classroom can be symptoms of unaddressed and untreated trauma that have been triggered and exacerbated in the school setting. As a result, this phenomenon contributes to the disproportionality of Black boys in special education and adds to the expansion of the school-to-prison pipeline.

This capstone provides a thorough examination of the literature in the form of …

Early Maturing Out Of Problematic Alcohol Use, Sarah J. Peterson

Theses and Dissertations--Psychology

Most research suggests that alcohol use peaks in the college years then declines into the mid-thirties (Jochman & Fromme, 2010). However, there is evidence that some individuals mature out earlier: downward trends for some individuals begin in college, with as many as one third of students decreasing their drinking (Baer et al., 2001). It is crucial to identify factors that differentiate those who decrease their drinking early from those who persist in high levels of consumption; doing so would clarify risk for college-related alcohol problems and perhaps subsequent alcohol use disorder, and aid in earlier targeted prevention and intervention. This …

Role Of Prior Knowledge In Timing Of Computer-Generated Feedback, Julie Faye Shirah

Theses and Dissertations--Psychology

Although often helpful, feedback sometimes has neutral or negative effects on learning (Hattie & Timperley, 2007; Kluger & DeNisi, 1996). For example, Fyfe and colleagues have found that the effects of feedback timing are moderated by students’ prior knowledge such that feedback has been useful for students with low prior knowledge, but has mixed effects on students with high prior knowledge (e.g., Fyfe et al., 2012; Fyfe, 2016). In this study, I extended Fyfe’s work by re-conceptualizing prior knowledge as knowledge of more familiar foundational concepts a learner brings to a learning task (Sidney & Alibali, 2017), which can be …

Mild Cognitive Impairment In Presurgical Deep Brain Stimulation For Parkinson's Disease, Elizabeth Roslyn Wallace

Theses and Dissertations--Psychology

Although clinically characterized by motor impairments, Parkinson's disease (PD) often affects cognition early in the disease course. Cognitive changes common in PD include visuospatial abnormalities and prominent executive function (EF) deficits, with 30% of individuals eventually developing Parkinson’s disease dementia (PDD). Mild cognitive impairment (MCI) has been identified as a transitional state between normal cognition and PDD. A large cohort of individuals with PD at the Kentucky Neuroscience Institute have undergone pre-surgical evaluations for deep brain stimulation, although cognitive performance in this cohort has never been probed. Baseline cognitive performance of this cohort from 2017-2020 was examined to characterize the …

Development And Cross-Validation Of Personality Assessment Inventory Decision Rules For The Identification Of Psychogenic Nonepileptic Seizures, Chelsea Marie Bosch

Theses and Dissertations--Psychology

The published literature on the Personality Assessment Inventory (PAI) for psychogenic nonepileptic seizure (PNES) diagnosis includes a variety of interpretation methods to distinguish PNES from epileptic seizures (ES) and offers mixed findings. The purpose of this study was to use a cross-validation approach to create and derive new decision rules for the PAI to best differentiate PNES from ES. Data from 773 patients (PNES n = 328, ES n = 445) who underwent long-term video EEG (vEEG) monitoring and completed a PAI were examined. Individuals with invalid PAI profiles were removed, and patients were randomly assigned to the “development” group …

Mental Health In The Courtroom: How Victim Mental Illness Impacts Juror Decision-Making In A Rape Case, Mary M. Levi

Theses and Dissertations--Psychology

The influence of mental illness on jury decision-making has rarely been investigated, and even fewer studies have examined how jurors perceive a victim with mental illness. The present study investigated the effect of victim mental illness on jury decision-making in a rape trial using a 3 (victim mental health status: schizophrenia, depression, no illness) x 2 (participant gender: female, male) between-subjects design. I hypothesized that mock jurors would render fewer guilty verdicts in the schizophrenia condition compared to the depression condition, and render fewer guilty verdicts in the schizophrenia and depression conditions compared to the control. I also hypothesized that …

"Think Of The Situation In A Positive Light": A Look At Cognitive Reappraisal, Affective Reactivity And Health, Jessica Chloe Maras

Theses and Dissertations--Psychology

How individuals regulate their emotions is critical for maintaining health and well-being. For example, reframing a stressful situation in a positive light, a form of cognitive reappraisal, is beneficial for health and well-being outcomes. However, it is currently unclear why this relationship exists. One potential mechanism could be how one emotionally reacts to stressors in daily life, termed affective reactivity. The current study examined longitudinal associations that spanned 20 years between cognitive reappraisal and health outcomes and subjective well-being and if affective reactivity mediated this relationship. Participants completed waves 1-3 of the Midlife in the United States (MIDUS) Survey series …

Effects Of An Online Insomnia Intervention On Sleep And Alcohol Consumption, Justin Verlinden

Theses and Dissertations--Psychology

Alcohol use disorder (AUD) and insomnia are highly comorbid, due in part to the use of alcohol as a sleep aid among individuals with insomnia. Initial studies have shown that cognitive behavioral therapy for insomnia (CBT-I), the first-line treatment for insomnia, is moderately successful at improving both sleep and drinking outcomes in heavy drinkers with insomnia. However, CBT-I is expensive and not widely available. Online CBT-I could be a more accessible alternative. One online CBT-I program, Sleep Healthy Using the Internet (SHUTi), is especially promising due to its high efficacy in treating insomnia and its individualized and interactive platform. Here …

Examining The Impact Of Discrete And Contextual Stress Factors On Memory, Jillian Rae Silva-Jones

Theses and Dissertations--Psychology

Stress is a complex and multifaceted process which is often not perceived as such. Therefore, given the unidimensional conceptualization of stress in previous research the current understanding of the associations between stress and memory are not well understood. This study investigates the association between stress and memory by capturing the complexity of stress through discrete and contextual stress factors. The current study used ecological momentary assessment (EMA) and geocoded indices (i.e., zip codes) of population density (i.e., urbanicity) and deprivation (socioeconomic disadvantage) in a large and diverse sample of U.S. participants (N = 8817) to examine the relationship between …

Enhancements To Uniformity Of Magnetic Fields At The Sns Nedm Experiment, Ahmad Saftah

Theses and Dissertations--Physics and Astronomy

The nEDM experiment at the Spallation Neutron Source (SNS) aims to increase
experimental sensitivity to hadronic CP violation by nearly two orders of magnitude.To do that the nEDMSNS experiment requires an extremely uniform magnetic field to maintain ³He polarization during transit to the measurement cell. The Magnetic Shield Enclosure (MSE) coil provides the required field. However, the superconducting shield distorts the MSE field.

This thesis discusses a magnetic cloak for the nEDM@SNS experiment that can restore the MSE field uniformity and cos theta coils designed to test the magnetic cloak in the first part. The second part of this …

Angular Distribution Of Electron-Helium Scattering In The Presence Of A 1.17 Ev Laser Field, Brian N. Kim

Theses and Dissertations--Physics and Astronomy

We have measured relative differential cross sections for 350 eV electrons scattered by a helium target in the presence of 1.17 eV photons from an Nd:YAG laser. We report an angular distribution of free-free electrons that were scattered elastically at angles between 15^o and 80^o and of free-free electrons that underwent the process of electron-impact excitation of helium to its unresolved (1s2s)¹S and (1s2p)¹P excited states at angles between 1^o and 80^o. Our experiments test the momentum transfer dependence and the relationship between elastic and inelastic scattering in the Kroll-Watson approximation. …

An Energy-Integrated Analysis For Measuring The Anomalous Precession Frequency For The Muon G − 2 Experiment At Fermilab, Laura Kelton

Theses and Dissertations--Physics and Astronomy

In the search for physics beyond the Standard Model, the Muon g − 2 Experiment at Fermilab (E989) will make the most precise measurement of the anomalous magnetic moment of the muon, a_μ. Improvements in precision come from both increased statistics and new techniques to significantly reduce previous systematic uncertainties. The muon a_μ is determined by extracting both the anomalous spin precession frequency, ω_a, and the average magnetic field sampled by the muons, B. Traditionally an energy threshold analysis method which requires reconstruction of decay positrons from the muon decay, μ⁺ → e^{+ …}