Digital Commons Network^™

Consequences Of Abiotic And Anthropogenic Stressors In The Antarctic Midge, Belgica Antarctica, Jack J. Devlin

Theses and Dissertations--Entomology

The ability to tolerate stress is key to maintaining fitness in extreme environments such as the polar regions. Subject to a myriad of extreme year-round abiotic conditions, invertebrates inhabiting the terrestrial ecosystems of Antarctica provide an excellent system to investigate adaptations to stress. Understanding the response of these species to abiotic and novel stressors is crucial in a world with rapidly occurring climate change and increasing anthropogenic activity. In this dissertation, I investigated physiological and molecular responses to naturally occurring and human-derived stresses in the midge Belgica antarctica, which is Antarctica’s only endemic insect.

In my first research chapter, I …

Malleability Of Abortion Attitudes, Allison Leip

Theses and Dissertations--Family Sciences

Although abortion attitudes have been thoroughly investigated and population-level attitudes have not changed much over the past half-century, polls and research inquiring about abortion attitudes tend to ask isolated questions about if, and in what circumstances, abortion should be legal. The purpose of this study was to examine the extent to which abortion attitudes both varied and changed according to several contextual factors. A multiple-segment factorial vignette was conducted with 530 respondents in the state of Kentucky. Overall, most respondents held strong attitudes on access to abortion, both before the rationale was provided and regardless of the rationale provided. However, …

Acting On Routine Outcome Monitoring, Virginia Courtney

Theses and Dissertations--Family Sciences

This thesis explores the application of an Acceptance and Commitment Therapy (ACT) informed approach in achieving clients’ therapeutic objectives via systematically tracking client progress over the therapy process. The study utilized the Marriage and Family Therapy Practice Research Network (MFT-PRN), a specific tool that aids the tracking of therapy progress, to gather relevant client data. The data consisted of therapy progress for 27 individuals the author worked with, 1,001 individuals from the Individual Relational and Finance Therapy Clinic, and 4,424 individuals from the MFT-PRN-Network. Upon collecting this data, progress trajectories were generated using Microsoft Excel to compare the author’s clients’ …

Assessing Endophyte Frequency Distributions And The Effect Of Epichloë Brachyelytri In The Chemotypic And Genotypic Diversity Of Brachyelytrum Erectum, Rachel Ann Sneed

Theses and Dissertations--Plant Pathology

Seed-transmissible epichloid fungal endophytes are best known for their roles as defensive mutualists in cool-season grasses. Historically, the discovery of fungal endophytes was driven by investigations of plant toxicity to livestock, followed by extensive study of their alkaloids and protection against insects and nematodes. Epichloae can produce four classes of alkaloids: ergot alkaloids, lolines (saturated aminopyrrolizidines), indole–diterpenes, and peramine. It is increasingly evident that these hereditary symbionts have much more diverse chemical profiles both in individual populations and between them. To this end, differences in chemotypic profiles of these symbionts may translate to different evolutionary and environmental advantages across plant …

Determining Population Structure In Kentucky Parascaris Univalens Specimens, Constance Finnerty

Theses and Dissertations--Veterinary Science

Parascaris univalens is a highly pathogenic nematode that affects the gastrointestinal system of young horses. When unaddressed, this parasite causes severe intestinal impactions and even death. Parascaris univalens is also found to have an emergence of anthelmintic resistances, causing a concern for horse owners. Despite its clinical significance, very little work has been done on Parascaris univalens to identify its population structure. This study aimed to determine the population structure of Parascaris univalens through Illumina next generation sequencing (NGS) on three hierarchical categorizations: within a horse, within an isolated herd, and within horses in the state of Kentucky. A total …

Genomic Studies Of The Equine Bloodworm, Strongylus Vulgaris, Nichol Ripley

Theses and Dissertations--Veterinary Science

Strongylus vulgaris is the most pathogenic nematode parasite of grazing horses worldwide. This gastrointestinal parasitic nematode is in the family Strongylidae under the subfamily Strongylinae, or Strongylins. While the epidemiology, complete life cycle, and high pathogenicity of the fourth and fifth larval stages of S. vulgaris are well established, we understand very little about its biology. This parasite is renowned for its unique life cycle and capacity to cause arterial damage, leading to significant health and economic impacts for the equine industry. It also is the most intensively documented Strongylin; however, S. vulgaris has yet to gain drug resistance as …

Temporal Changes In The Genome Of Apicomplexan Parasite Sarcocystis Neurona Sn3, Jamie Norris

Theses and Dissertations--Veterinary Science

Sarcocystis neurona is an apicomplexan parasite and the main etiologic agent behind Equine Protozoal Myeloencephalitis (EPM), the most diagnosed neurologic disease in horses living in the Americas. Technical advances that arose from the human genome project between 1990 and 2003 and the corresponding “omics” revolution in research have allowed scientists novel approaches to study organisms. Herein, we sought to leverage bioinformatic advances and new sequencing platforms to provide an improved understanding of the biology of S. neurona. At the outset of this project, reference genomes from two different S. neurona strains (SN3.e1 and So SN1) were available. A new and …

Autism In Agricultural Education: A Case Study Of An Adolescent With Autism Spectrum Disorder And Their Parent On Career And Technical Education, Grace Miller

Theses and Dissertations--Community & Leadership Development

Autism spectrum disorder (ASD) is a unique and often misunderstood diagnosis. Little is known about the experiences of adolescents with ASD. As students with ASD graduate high school, many are under- and unemployed. Career and technical education (CTE) in U.S. schools is intended to prepare all students for careers post-secondary. Agricultural education is one of the predominate career clusters within CTE. This qualitative single case study sought to create a platform for both a student and their parent to share their experiences in agricultural education and CTE. Participants were an adolescent with ASD who had taken at least one year …

Exploring The Impact Of An Appalachian Higher Education Institution Had On Fostering Solidarity, Capacity, And Agency Of Female Appalachian Students Seeking To Positively Influence The Quality Of Life For Themselves And Appalachian Communities, Analiese Mitchell

Theses and Dissertations--Community & Leadership Development

Appalachian women navigating higher education encounter multifaceted challenges, often confronting marginalization and a lack of representation within academic spaces. This study investigates the experiences of female Appalachian students at Mountain University in Kentucky, aiming to shed light on their journey and the university's impact on their lives and communities. Drawing on qualitative data from interviews, the research explores themes of solidarity, capacity, agency, and Quality of Life. Findings reveal a robust sense of solidarity among Appalachian peers and faculty, fostering a supportive environment conducive to personal and academic growth. Participants express opportunities to engage with their communities positively, contributing to …

The Efficacy Of Wetland Treatment Systems Used To Treat Runoff Mixtures From Different Landscapes Across Kentucky, Emily Nottingham

Theses and Dissertations--Biosystems and Agricultural Engineering

The overarching goal was to improve our understanding of the cumulative effect of increased use and occurrence of commonly detected contaminants of potential concern (CPCs) on nitrogen (N) transformation processes in wetlands. The central hypothesis was that those various mixtures of nutrients and CPCs entering treatment wetlands impact N removal pathways. The first study assessed the current state of the literature on the implications to N removal in wetlands in the presence of pesticides and antibiotics. 181 primary studies were identified. Removal efficiencies for nitrate varied widely across the studies, with CPCs impacting microbial communities. A knowledge gap remains in …

Point Of Care Ultrasound (Pocus) For Advanced Practice Providers (Apps), Crystal S. Rogers

DNP Projects

Background: Advanced practice providers (APPs) routinely lack the skillset to perform Point of Care Ultrasound (POCUS) because currently, there is not a standardized curriculum within scholarly programs (Santos et al., 2018) and/or inadequate hospital training to perform these competencies (Huang et al., 2021). The absence of a standard curriculum has limited the ability of APPs to practice with full scope, provide care that is comparable to physician partners in the acute care setting, and deliver highest quality of patient care. Implementing standard education to train APPs for POCUS addresses this identified gap.

Purpose: The purpose of this project was to …

A Case Study In Program Evaluation, Lydia Williams

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The three core functions of public health are assessment, policy development, and assurance, and program evaluation falls under the latter category. A program is incomplete without an in-depth understanding of how well it works and what steps can be taken to make sure there is continuous progress and improvement.

In this case study, I developed an evaluation plan for the Lexington-Fayette County Health Department’s (LFCHD) infectious disease outbreak education program. The need for such a program was realized after a MRSA outbreak among a Kentucky high school football team. This case study employed the Center for Disease Control and Prevention …

Patterns Into Pathways For Improving Safety Culture: Refined Latent Class Analysis Informs Tailored Decision Support For South Carolina Dss Safety Culture Improvements, Michaela Voit

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The rising prevalence of exposures to adverse childhood experiences (ACEs) demands a coordinated public health response, as a significant body of research details the cumulative impact of ACEs on chronic morbidities contributing to reduced life expectancy. Child welfare workers (CWW) are embedded in this public health effort, tasked with preventing and mitigating the impacts of ACEs through family and prevention services. The National Partnership for Child Safety (NPCS) may improve the wellbeing of CWWs and the effectiveness of Child Welfare (CW) services by improving the quality of safety culture within CW organizations. To inform NPCS quality improvement efforts, our project …

Bayesian And Frequentist Approaches To Rescuing Disrupted Trials, Cornelia Ursula Kunz, Sergey Tarima, Gary L. Rosner, Richard Emsley, Madeline Bauer, Christopher Jennison, James L. Rosenberger, Nigel Stallard, Sarah Zohar, Nancy Flournoy

Biostatistics Faculty Publications

The COVID-19 pandemic impacted clinical trials in ways never expected. However, similar challenges should now be expected going forward. These challenges made us aware of statistical problems arising from other types of disruptions that had not previously captured the attention of the statistical community. This article describes some frequentist and Bayesian statistical tools that can be used with future disruptions and illuminates issues that could benefit from more statistical research. Disruptions may threaten a clinical trial’s validity. Here, we address two resultant challenges: (a) performing an unplanned analysis with options to stop and/or change the sample size; and (b) changes …

Gwas Of Multiple Neuropathology Endophenotypes Identifies New Risk Loci And Provides Insights Into The Genetic Risk Of Dementia, Lincoln M.P. Shade, Yuriko Katsumata, Erin L. Abner, Khine Zin Aung, Steven A. Claas, Qi Qiao, Bernardo Aguzzoli Heberle, J. Anthony Brandon, Madeline L. Page, Timothy J. Hohman, Shubhabrata Mukherjee, Richard P. Mayeux, Lindsay A. Farrer, Gerard D. Schellenberg, Jonathan L. Haines, Walter A. Kukull, Kwangsik Nho, Andrew J. Saykin, David A. Bennett, Julie A. Schneider, Julie A. Schneider, Lindsay A. Farrer, Richard P. Mayeux, Subhabrata Mukherjee, Andrew J. Saykin, Walter A. Kukull

Biostatistics Faculty Publications

Genome-wide association studies (GWAS) have identified >80 Alzheimer’s disease and related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in most previous studies belie the complex nature of underlying neuropathologies. Here we performed GWAS on 11 ADRD-related neuropathology endophenotypes with participants drawn from the following three sources: the National Alzheimer’s Coordinating Center, the Religious Orders Study and Rush Memory and Aging Project, and the Adult Changes in Thought study (n = 7,804 total autopsied participants). We identified eight independent significantly associated loci, of which four were new (COL4A1, PIK3R5, LZTS1 and APOC2). Separately testing known ADRD loci, 19 loci …

Individual-Network Based Predictions Of Microbial Interaction Signatures For Response To Biological Therapies In Ibd Patients, Federico Melograna, Padhmanand Sudhakar, Behnam Yousefi, Clara Caenepeel, Gwen Falony, Sara Vieira-Silva, Sreenikhitha Krishnamoorthy, David Fardo, Bram Verstockt, Jeroen Raes, Severine Vermeire, Kristel Van Steen

Biostatistics Faculty Publications

Inflammatory Bowel Disease (IBD), which includes Ulcerative Colitis (UC) and Crohn’s Disease (CD), is marked by dysbiosis of the gut microbiome. Despite therapeutic interventions with biological agents like Vedolizumab, Ustekinumab, and anti-TNF agents, the variability in clinical, histological, and molecular responses remains significant due to inter-individual and inter-population differences. This study introduces a novel approach using Individual Specific Networks (ISNs) derived from faecal microbial measurements of IBD patients across multiple cohorts. These ISNs, constructed from baseline and follow-up data post-treatment, successfully predict therapeutic outcomes based on endoscopic remission criteria. Our analysis revealed that ISNs characterised by core gut microbial families, …

Stigma And Efficacy Beliefs Regarding Opioid Use Disorder Treatment And Naloxone In Communities Participating In The Healing Communities Study Intervention, Nicky Lewis, Barry Eggleston, Redonna K. Chandler, Dawn Goddard-Eckrich, Jamie E. Luster, Dacia Beard, Emma Rodgers, Rouba A. Chahine, Philip M. Westgate, Shoshana N. Benjamin, Janae Holloway, Thomas Clarke, R. Craig Lefebvre, Michael D. Stein, Donald W. Helme, Jennifer Reynolds, Sharon L. Walsh, Darcy Freedman, Nabila El-Bassel, Kara Stephens, Anita Silwal, Michelle R. Lofwall, Janet E. Childerhose, Hilary L. Surratt, Brooke N. Crockett, Amy L. Farmer, James L. David, Laura Fanucchi, Judy Harness, Ben Wilburn, Kelli Bursey, Kristin Mattson, Sarah Mann, Rebecca D. Jackson, Aimee Shadwick, Katherine Calver, Deborah Chassler, Jennifer Kimball, Nancy Regan, Jeffrey H. Samet, Rachel Sword-Cruz, Michael D. Slater

Biostatistics Faculty Publications

Background The HEALing Communities Study (HCS) included health campaigns as part of a community-engaged intervention to reduce opioid-related overdose deaths in 67 highly impacted communities across Kentucky, Massachusetts, New York, and Ohio. Five campaigns were developed with community input to provide information on opioid use disorder (OUD) and overdose prevention, reduce stigma, and build demand for evidence-based practices (EBPs). An evaluation examined the recognition of campaign messages about naloxone and whether stigma and efficacy beliefs regarding OUD treatment and naloxone changed in HCS intervention communities.

Methods Data were collected through surveys offered on Facebook/Instagram to members of communities participating in …

Financial Monitoring And Oversight Of Public Higher Education Institutions By States A Descriptive Case Study Analysis, Ryan Kaffenberger

MPA/MPP/MPFM Capstone Projects

Higher education in America is at an inflection point with numerous challenges threatening the traditional business model relied on by institutions across the country. These forces include, but are not limited to: 1) A decrease in the number of high school graduates due to historical declines in birth rates (Grawe, 2018; Western Interstate Commission for Higher Education, 2020) 2) Sustained disinvestment by many states in their higher education institutions which has effectively shifted the cost of education to students and families (Kunkle & Laderman, 2023) 3) Increasing skepticism among Americans of the value of higher education, particularly given its rising …

Lfcug's Utilization Of 2022 Opioid Settlement Funds For Recovery Housing, Emily Wiley, Ken Britton Jr, Madelaine Coy

MPA/MPP/MPFM Capstone Projects

Following national settlements to combat the opioid epidemic, Kentucky and its local governments received a collective $842 million to invest in prevention and treatment. To employ these dollars most effectively, Lexington-Fayette Urban County Government (LFUCG) aims to become “recovery ready” as a part of Kentucky’s Recovery Ready Communities (RRC) certification program. This mixed methods comparative case study determined the following high-priority variables that align with RRC certification requirements: recovery housing infrastructure, certification disclosure, and medications for opioid use disorder (MOUD) services. To provide additional insight into Fayette County’s recovery housing landscape, we analyzed the following supplemental variables: vulnerable populations served, …

Sports Betting In Kentucky: An Analysis Of Kentucky’S Sports Wagering Legislation Through Local And Regional State Budgetary Revenue Trends, Brett Gillispie

MPA/MPP/MPFM Capstone Projects

Kentucky’s legislation legalizing sports wagering in the Commonwealth and delineating its taxation, HB551 of the 2023 Regular Session of the General Assembly, has been implemented and posted numbers in its early months that suggested it will exceed revenue projections for the Commonwealth. Researchers have raised concerns, particularly in studying West Virginia, which implemented similar legislation in 2019, that sports betting may be cannibalizing existing gambling revenue for states that implement it. However, this was not conclusive. While evidence from West Virginia suggests that sports betting may be cannibalizing existing revenue, evidence from Kentucky and the individual and broader regional trends …

The Impact Of Actuarial Valuation Reporting On State Pension Funds, Samantha Montgomery

MPA/MPP/MPFM Capstone Projects

The U.S. is currently experiencing a public pension funding crisis that has become the topic of news outlets around the country and political talking points for legislators. It is estimated at the end of fiscal year 2023 that the average funded ratio for a public pension program is 78.1%, which equates to total unfunded pension liabilities for state retirement systems being approximately $1.4 trillion (Pension Plan Funded Ratio Rankings 2023, 2024). Pension systems across the U.S. are managed by boards and pension agencies that are charged with fiduciary responsibility to manage the pension funds in a manner that focuses on …

Evaluating The Impact Of Patient Acuity On Nursing Productivity: A Case Study At Uk Healthcare Chandler Hospital, Kara Klein

MPA/MPP/MPFM Capstone Projects

This study examines the relationship between patient acuity and nursing productivity at UK HealthCare (UKHC) Chandler Hospital from June 2022 to April 2024. Patient acuity, characterized by the complexity and intensity of nursing care required by patients (Juvé-Udina et al., 2020), is crucial in determining staffing needs and operational efficiency. The primary objective of this research is to investigate how variations in patient acuity levels impact Full-Time Equivalents (FTE), a key metric for assessing nursing productivity. The study utilized hospital data and applied descriptive statistics, correlation analyses, and regression models to assess the impact of patient acuity on FTE. The …

Enhancing Equity And Economic Growth: A Strategic Review Of Procurement Practices In Prince George’S County, Andrew Stover

MPA/MPP/MPFM Capstone Projects

Procurement represents a substantial portion of public spending in state and local governments, and thus is an essential element of responsible public financial management. This paper explores the procurement process on the local government level and provides research into best practices that are conducive to equity and economic development. It takes a look specifically at Prince George’s County, Maryland and analyzes its procurement function in relation to these best practices. An analysis of the County finds that despite its strides in implementing equitable procurement policies, significant gaps remain in the engagement of disadvantaged classes of businesses. To tackle these challenges, …

From Local Income Tax To Local Sales Tax In Kentucky: An Examination Of Lfucg, Zachary Vogl

MPA/MPP/MPFM Capstone Projects

Property tax revenue is widely known as the largest own source revenue for local governments. However, other taxes such as local sales taxes (LST) and local incomes taxes (LIT) also provide significant revenue streams for local governments. For example, in Kentucky, “[e]xcluding Fayette and Jefferson, counties collected a total of $353.5 million in occupational license fees on payroll and net profits in FY 2022, making up 42.7 percent of all tax revenue” (Smith 2024).

The use of LST and LIT, in addition to property taxes, by local governments allows for flexibility and revenue diversification; but, these taxes also come with …

The Fairness Model Of Legal Institutions, James M. Donovan

Law Faculty Books and Chapters

If any group is to endure over time, individual frustrations, while inevitable, must be usually experienced as acceptable, or at least tolerable. Failing that, little would prevent the losers in these conflicts from leaving or revolting, which would be cumulatively debilitating to the group. As opposed to holding law’s job to impose order and police infringers, the second approach suggests that finding the balance between group and individual desires is the ‘major difficulty of all law—the problem of really getting a fresh start in relations between litigants after disposition of a trouble-case. This is the problem not only of keeping …

The Next Frontier In Plan Fee Litigation: Health Plan Fees, Kathryn L. Moore

Law Faculty Books and Chapters

On September 11, 2006, Jerry Schlichter, a personal injury lawyer from Saint Louis, Missouri, filed some of the first lawsuits claiming that excessive fees in 401(k) plans violated ERISA’s fiduciary standards. Since then, hundreds of suits have been filed challenging retirement plan fees, and the Supreme Court has rendered two decisions in cases claiming that excessive 401(k) plan fees violated ERISA’s fiduciary standards. Since the Supreme Court issued the second decision in 2022, retirement plan excessive fee litigation may have begun to slow. There may, however, be a new frontier in plan fee litigation: health care plan fees.

This article …

Ben Moore's "Ode To A Nightingale" For Baritone Voice And Piano: A Performer's Guide, Jeremy Kelly

Theses and Dissertations--Music

This project is a performance guide of Ben Moore’s (b. 1960) Ode to a Nightingale (2014), a song cycle for baritone set to the poetry of John Keats. Song cycles are an important fixture in classical voice performance, as well as academia, and there is a need to promote new works by American composers. Moore’s Ode to a Nightingale is a unique contribution to the song cycle catalog as it sets John Keats’s eight stanzas of the singular poem to eight separate songs, something that is exceedingly rare in practice. Combining analysis of Moore’s songs in Ode to a Nightingale …

Mapping The Double-Tongue: Incorporating Body Mapping Into The Double-Tonguing Learning Process, Camilla Yoder

Theses and Dissertations--Music

As the articulation technique of double-tonguing is becoming more necessary and desirable for oboists to learn, this document explores the benefits of incorporating Body Mapping methods and kinesthetic awareness exercises into the double-tonguing learning process. These methods of body exploration are applied only to the areas of the body deemed highly relevant to accomplishing double-tonguing: the atlanto-occipital joint, the temporo-mandibular joint, the throat, the tongue, and the roof of the mouth. To explore the effectiveness of this approach, an Institutional Review Board approved research study was conducted, in which eight oboists learned double-tonguing with a preliminary iteration of this method. …

Mediating Authenticity: An Ethnographic Portrait Of Experience At U.S. Popular Music Festivals, Elizabeth Navarra Varnado

Theses and Dissertations--Music

This ethnographic study of U.S. popular music festivals subverts the impression of festivals as strictly ‘presentational’ live music events by utilizing a nuanced approach that is grounded in ethnographic fieldwork, historical analysis, and participant interviews.

Interlocutors, drawn from the author’s personal network of festival attendees, musicians, and promoters, reflect on “particularly positive festival moments,” the social and emotional benefits of festivals, and the corporeality of festival aesthetics. Discourse and published media play a vital role in festival participants’ perception of the festival field and their place within it; therefore, this study draws inspiration from the tripartite focus of iconic festival …

Evaluation Of The Management Of Italian Ryegrass (Lolium Perenne Ssp. Multiflorum) Using Harvest Weed Seed Control At Winter Wheat Harvest In Kentucky, Hayden Love

Theses and Dissertations--Plant and Soil Sciences

With increasing herbicide resistant weed populations in Kentucky winter wheat, producers are looking for new weed control options for Italian ryegrass (Lolium perenne L. ssp. multiflorum Lam.). A field study was conducted to better understand Italian ryegrass seed dispersal and the effectiveness of the Redekop seed control unit at winter wheat harvest in Kentucky. During harvest, the number of Italian ryegrass seeds shattering at the combine header, in the chaff, and contained in the grain tank was not significantly different. When the grain and chaff samples were combined, significantly more Italian ryegrass seed entered the combine. The integrated …