Digital Commons Network^™

Addressing Multimodal Transportation Needs Through Complete Streets Implementation, Eirini Stavropoulou, Nikiforos Stamatiadis, William Staats, Teng Wang, Reginald Souleyrette

Kentucky Transportation Center Research Report

Since the early 2000s, over 1,600 transportation agencies in the United States have adopted Complete Streets policies. Recently, the Kentucky Transportation Cabinet (KYTC) published its Complete Streets, Roads, and Highways Manual, which aims to implement a safe and equitable transportation system throughout the state, as well as a Complete Streets policy. The manual and policy offer guidance on integrating Complete Streets principles into road design, however, KYTC currently lacks tools or methods to evaluate how well specific projects address Complete Streets goals. This is problematic because systematic assessments are needed to effectively prioritize projects and allocate scarce funding. Based …

Balancing Environmental Clearances With Construction Work Zone Needs, Chris Van Dyke, Steve Waddle, Ying Li

Kentucky Transportation Center Research Report

On small, single-span bridge projects (< 100 feet), the Kentucky Transportation Cabinet (KYTC) during project development works to establish an environmentally clear area (ECA) large enough to accommodate contractor operations. An adequately sized ECA gives contractors sufficient room to have materials delivered, park vehicles, store materials, and maneuver equipment around the project site (e.g., cranes, drill rig). If a contractor finds an ECA is too small to support their operations, they are responsible for obtaining additional environmental clearances. Clearing additional areas following the project award can slow down project delivery. To reduce the likelihood of contractors needing to enlarge an ECA, this report includes four documents KYTC can implement immediately to streamline and clarify the environmental clearances process. They include a checklist that project managers can use to coordinate the work of project team members and verify environmental clearances are on track, a combined environmental clearances workflow and best practices document for use by environmental subject-matter experts (SMEs), proposed language that can be inserted into project proposals that describes the environmental clearance process and specifies materials the Cabinet will hand off to contractors showing the location of the ECA, and a one-page explainer for contractors describing the environmental clearances process. Taken together, these deliverables emphasize the importance of early and ongoing coordination among project team members, clearing as much area as practical in and around bridges, and being transparent with contractors about their responsibilities.

Are “10 Grams Of Protein” Better Than “Ten Grams Of Protein”? How Digits Versus Number Words Influence Consumer Judgments, Marisabel Romero, Adam W. Craig, Milica Mormann, Anand Kumar

Marketing & Supply Chain Faculty Publications

Numerical information can be communicated using different number formats, such as digits (“5”) or number words (“five”). For example, a battery product may claim to last for “5 hours” or “five hours.” And while these two formats are used interchangeably in the marketplace, it is not clear how they influence consumer judgments and behavior. Via six experimental studies, two online ad campaigns, and one large secondary dataset analysis, we find that digits, compared to number words, positively affect consumer behavior. We refer to this phenomenon as the number format effect. We further show that the number format effect occurs because …

Quantifying Image Quality In Aoslo Images Of Photoreceptors, Brea D. Brennan, Heather Heitkotter, Joseph Carroll, Sergey Tarima, Robert F. Cooper

Biostatistics Faculty Publications

The use of “quality” to describe the usefulness of an image is ubiquitous but is often subject to domain specific constraints. Despite its continued use as an imaging modality, adaptive optics scanning light ophthalmoscopy (AOSLO) lacks a dedicated metric for quantifying the quality of an image of photoreceptors. Here, we present an approach to evaluating image quality that extracts an estimate of the signal to noise ratio. We evaluated its performance in 528 images of photoreceptors from two AOSLOs, two modalities, and healthy or diseased retinas. The algorithm was compared to expert graders’ ratings of the images and previously published …

A Cautionary Tale About Properly Vetting Datasets Used In Supervised Learning Predicting Metabolic Pathway Involvement, Erik D. Huckvale, Hunter N. B. Moseley

Markey Cancer Center Faculty Publications

The mapping of metabolite-specific data to pathways within cellular metabolism is a major data analysis step needed for biochemical interpretation. A variety of machine learning approaches, particularly deep learning approaches, have been used to predict these metabolite-to-pathway mappings, utilizing a training dataset of known metabolite-to-pathway mappings. A few such training datasets have been derived from the Kyoto Encyclopedia of Genes and Genomes (KEGG). However, several prior published machine learning approaches utilized an erroneous KEGG-derived training dataset that used SMILES molecular representations strings (KEGG-SMILES dataset) and contained a sizable proportion (~26%) duplicate entries. The presence of so many duplicates taint the …

Trilogies: Lessons From 50 Years Facilitating Community-Based Health Assessments And Planning In Appalachia, Bruce Behringer

Journal of Appalachian Health

Involvement of community and organizational groups is fundamental to most public ventures. Most social, health, economic, and educational improvements in Appalachia have been characterized by successfully integrating community input and finding ways to encourage organizational change and collaboration.

Managing group process and related facilitation skills are fundamental competencies for public health professionals and others guiding change efforts. Groups from communities and organizations can get stalled in their deliberations; a facilitator frequently must think quickly to diagnose the situation and propose alternative approaches. Creative and flexible approaches, learned through practice experiences, can blend with theories and frameworks learned in academic preparation …

Overexpression Of Fatty Acid Synthase Upregulates Glutamine–Fructose-6-Phosphate Transaminase 1 And O-Linked N-Acetylglucosamine Transferase To Increase O-Glcnac Protein Glycosylation And Promote Colorectal Cancer Growth, James Drury, Mariah E. Geisen, Josiane Weber Tessmann, Piotr G. Rychahou, Courtney O. Kelson

Markey Cancer Center Faculty Publications

Fatty acid synthesis has been extensively investigated as a therapeutic target in cancers, including colorectal cancer (CRC). Fatty acid synthase (FASN), a key enzyme of de novo lipid synthesis, is significantly upregulated in CRC, and therapeutic approaches of targeting this enzyme are currently being tested in multiple clinical trials. However, the mechanisms behind the pro- oncogenic action of FASN are still not completely understood. Here, for the first time, we show that overexpression of FASN increases the expression of glutamine–fructose-6-phosphate transaminase 1 (GFPT1) and O-linked N-acetylglucosamine transferase (OGT), enzymes involved in hexosamine metabolism, and the level of O-GlcNAcylation in vitro …

Check With The Intended Audience First! Content Validation As A Method For Inclusive Research For Primary Care Engagement In Rural Appalachia, Sydeena E. Isaacs, Jennifer Schroeder Tyson, Ashley Parks, Danielle Adams

Journal of Appalachian Health

Introduction: To date, referral practices based on social determinants of health (SDOH) among primary care providers (PCPs) and clinic staff in rural regions, including Appalachian North Carolina (NC), are not well understood.

Purpose: This study aims to develop and content validate a primary care engagement (PCE) survey to assess (1) engagement and burnout; (2) referral practices; and (3) self-efficacy and confidence in making referrals based on SDOH among PCPs and clinic staff in Appalachian NC.

Methods: Using the Social-Ecological Model as a theoretical framework, researchers developed a 37-item PCE survey. Content validation was completed by a panel of experts recruited …

Decistifying Trans And Gender Diverse Inclusion In Library Work: A Literature Review, Stephen G. Krueger, Keahi Adolpho

Library Faculty and Staff Publications

This comprehensive review illuminates the current state of scholarly literature on trans and gender diverse inclusion in libraries, with the intention to provide a foundation and identify gaps for further research. Covering 50 works published between 2002 and 2023 in the areas of general inclusion, public libraries, academic libraries, experiences of library workers, archives, information behavior, and cataloging, we found that, with the exception of works on archives and cataloging, little scholarly literature goes beyond introductory talking points on basic information about trans and gender diverse people. We conclude with a call for much more in-depth research on this essential …

Selection And Agronomic Characterization Of Leucaena Spp. Genotypes For Cold Tolerance. I. Dry Matter Yield., M C. Goldfarb, J F. Casco

IGC Proceedings (1977-2023)

Biotypes of Leucaena spp (56) were evaluated in order to identify those with tolerance to low temperature and with desirable characteristics as a forage crop. Selection was done at two phases. Phase I: 92 days old seedlings (n=2800) were subjected at two temperatures treatments during 14 hours: T1= -8 °C and T2= -3 °C. Selection criteria was established as 50% of live leaves remained after treatments were applied. Phase II: Plants that survived phase I were planted at field conditions and agronomic characteristics were measured. Seventeen plants were selected from eleven different biotypes, resulting one from T1 and the rest …

Will Our Future Selves Thank Us? An Examination Of Born-Digital Curation Practices At The University Of Kentucky Libraries, Megan M. Mummey, Andrew Mcdonnell, Emily B. Collier, Sarah Dorpinghaus, Ruth E. Bryan

Library Presentations

Cultural heritage resources are increasingly being produced and distributed digitally yet the world of physical materials has not declined. Can you realign current resources to meet future collection needs while at the same time continuing with existing collection needs? Analog-based archival theory and practice is still relevant, but born-digital formats make acquisition, appraisal, resource allocation, collection management, and external relationships much more challenging. These challenges range from monetary and environmental costs to resource allocation to social media technology woes to campus-wide IT relationships.

In this presentation, University of Kentucky archivists share practical tips, tools, and mental frameworks to identify gaps, …

Water Use Efficiency In Chilean And Argentine Humid Temperate Grass-Legume Pastures, H G. Landi, M H. Wade, V Garcia De Cortazar, D E. Dalla Valle

IGC Proceedings (1977-2023)

At two sites in Argentina and Chile five levels of water input were applied to four sown pastures of varying ages during spring and summer. The pastures consisted principally of C3 grasses and legumes, some of which were sown such as Lolium perenne, Trifolium repens, Dactylis glomerata. Dry matter (DM) production was measured and related to the estimated total evapotranspiration (ET): responses were both highly linear. Both responses to ET and absolute yields were higher at the Argentinian than at the Chilean site: respectively 10.7 and 15.2 kg DM/mm water evapotranspired. Nevertheless the calculated indices of sensitivity (Ky) of Doorenbos …

Increased Perceived Confidence In Professional Role Skills Among Undergraduate Dietetic Students Following Simulation-Based Learning Experiences, Makenzie Barr-Porter, Elizabeth Combs, Lauren Batey, Dawn Brewer, Aaron Kyle Schwartz, Tammy Stephenson

UK CARES Faculty Publications

Simulation-based learning experiences (SBLEs) are effective for teaching healthcare students clinical and communication skills. The current study assessed self-perceived clinical and communication confidence among dietetics students completing a series of four SBLEs (3 group, 1 individual) across nine months. Dietetics students were recruited in February 2023 prior to their first SBLE. Simultaneously through the academic year, students completed clinical and communication courses. Students were invited to complete an online, anonymous self-reported survey regarding confidence with nutrition care and communication prior to their first SBLE (Time 1), prior to their third SBLE (Time 2), and following their final SBLE (Time 3). …

Open Educational Resources In Kentucky, Stephen G. Krueger, Todd Seguin, Colleen Deel, Aj Boston, Lidiya Grote, Bailey Lake, Katrina Salley, Stacy Scott, Kelly Smith, Maria Taylor, Kathleen Richardson

Library Faculty and Staff Publications

Open educational resources (OER) play an increasingly important role in the education landscape, with increased awareness and use year over year (Coffey). Often, academic libraries play a supporting role for instructors as they locate, adopt, and create OER for their courses. In this article, we will provide an introduction to OER, outline some current trends in open education, and describe a few of the OER initiatives currently underway in Kentucky’s college and university libraries.

Are Transformative Agreements Worth It? An Analysis Of Open Access Publication Data At The University Of Kentucky, Ben Rawlins

Library Faculty and Staff Publications

Open access publishing is continuing to grow as funders such as cOAlition S, National Institutes of Health, and the White House implement mandates and requirements that publicly funded research be made immediately available for public consumption. Publishers have adopted open access as a business model through transformative agreements that combine subscription and publishing fees. However, it is unclear whether these agreements are beneficial for libraries. This article discusses a project by the University of Kentucky Libraries to gather and analyze open access publication data to aid in the evaluation of transformative agreement proposals. This article also discusses how the University …

Guidebook For Project Management, Jill Asher, Keith Caudill, Travis Thompson, Jeff Jasper, Chris Van Dyke, Samantha Wright, Bryan Gibson, Pam Clay-Young, Candice Wallace

Kentucky Transportation Center Research Report

For the Kentucky Transportation Cabinet’s (KYTC) Department of Highways, project development encompasses all the work activities needed to move a transportation project from concept and project initiation to construction letting. Developing projects efficiently requires the adoption of sound project management practices. Although KYTC has a long track record of executing complex projects, doing so is increasingly challenging due to staff attrition and the attendant loss of institutional knowledge. Today’s entry- and mid-level project managers have more responsibilities than ever but lack a trusted source of guidance to help them manage projects from development through completion. The objective of this study …

New Voices For A Better Society, Stephanie J. Diem, Baindu L. Bayon, Hussam Mahmoud, Mary L. Garcia- Cazarin, Michael J. Martin, Clare C. Rittschof, Patricia Silveyra, Umut A. Gurkan, Alison Boland- Reeves, Dalal Najib, Flannery Wasson

Entomology Faculty Publications

No abstract provided.

Toward Transparent Taxonomy: An Interactive Web-Tool For Evaluating Competing Taxonomic Arrangements, Oksana V. Vernygora, Felix A. H. Sperling, Julian R. Dupuis

Entomology Faculty Publications

Informative and consistent taxonomy above the species level is essential to communication about evolution, biodiversity and conservation, and yet the practice of taxonomy is considered opaque and subjective by non-taxonomist scientists and the public alike. While various proposals have tried to make the basis for the ranking and inclusiveness of taxa more transparent and objective, widespread adoption of these ideas has lagged. Here, we present TaxonomR, an interactive online decision-support tool to evaluate alternative taxonomic classifications. This tool implements an approach that quantifies the criteria commonly used in taxonomic treatments and allows the user to interactively manipulate weightings for different …

Patient Experience Of Head And Neck Surgery With Free Flap Reconstruction., Lillian W. Dattilo, Trinity I. Russell, Chloe B. Warinner, Heather Starmer, Donald J. Annino, Laura A. Goguen, Rosh K. V. Sethi, Ravindra Uppaluri, Melina Windon, Regan W. Bergmark, Eleni M. Rettig

Markey Cancer Center Faculty Publications

IMPORTANCE: Major head and neck surgery with microvascular free tissue transfer reconstruction is complex, with considerable risk of morbidity. Little is known about patients' experiences, including decision-making prior to, and regret following, free flap surgery.

OBJECTIVE: To characterize patient experiences and decision regret of patients undergoing head and neck reconstructive free flap surgery.

DESIGN, SETTING, AND PARTICIPANTS: This mixed-methods cohort study comprising semistructured interviews was conducted June to August 2021 at a single tertiary academic cancer center. Participants underwent head and neck reconstructive surgery with microvascular free tissue transfer (flap) more than 3 months before recruitment (range, 3 months to …

Myeloid-Derived Suppressor Cell Mitochondrial Fitness Governs Chemotherapeutic Efficacy In Hematologic Malignancies, Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R. Macdonald, Manu Pandey, Mounika Goruganthu, Nathan Roberts, Prashant K. Singh, Richard M. Higashi, Andrew N. Lane, Teresa W-M Fan, Jianmin Wang, Philip L. Mccarthy, Elizabeth A. Repasky, Hemn Mohammadpour

Markey Cancer Center Faculty Publications

Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial fitness controls the efficacy of doxorubicin chemotherapy in a preclinical lymphoma model. Mechanistically, we show that triggering STAT3 signaling via β2-adrenergic receptor (β2-AR) activation leads to improved MDSC function through metabolic reprogram- ing, marked by sustained mitochondrial respiration and higher ATP generation which reduces AMPK signaling, altering energy metabolism. Furthermore, induced STAT3 signaling in MDSCs enhances glutamine consumption via the TCA cycle. Metabolized glutamine generates itaconate which downregulates mitochondrial reactive oxygen species via regulation of …

Colorectal Cancer Survival Disparities In The Five Regions Of Georgia, Meng-Han Tsai, Daramola N. Cabral, Caitlyn Grunert, Justin X. Moore

Markey Cancer Center Faculty Publications

Background/objective

The objective of this study was to examine 5-year colorectal cancer survival rates. We also determined whether demographics, tumor characteristics, and treatment modality were associated with 5-year CRC survival in the Clayton, West Central, East Central, Southeast, and Northeast Georgia regions because the significant higher CRC mortality rates in these regions in comparison to the overall rates in the State of Georgia.

Methods

We conducted a retrospective cohort analysis using data from the 1975–2016 Surveillance, Epidemiology, and End Results program aggregated CRC patients to these five regions. Five-year CRC survival was calculated and stratified by the five regions of …

Altered Lipid Metabolism In Apc-Driven Colorectal Cancer: The Potential For Therapeutic Intervention, Courtney O. Kelson, Yekaterina Y. Zaytseva

Markey Cancer Center Faculty Publications

Altered lipid metabolism is a well-recognized feature of solid cancers, including colorectal cancer. In colorectal cancer, upregulation of lipid metabolism contributes to initiation, progression, and metastasis; thus, aberrant lipid metabolism contributes to a poor patient outcome. The inactivating mutation of APC, a vital tumor suppressor in the Wnt signaling pathway, is a key event that occurs early in the majority of colorectal cancer cases. The potential crosstalk between lipid metabolism and APC-driven colorectal cancer is poorly understood. This review collectively highlights and summarizes the limited understanding between mutations in APC and the upregulation of Wnt/beta- catenin signaling and lipid metabolism. …

Advances In Breeding Apomictic Brachiaria In Tropical America, J W. Miles, C B. Do Valle

IGC Proceedings (1977-2023)

Prior to 1988 Brachiaria improvement was based exclusively on the collection, introduction, and evaluation of natural germplasm from Africa. Breeding programs in Brachiaria have been possible only in the past 10 years with the creation of a sexual, tetraploid B. ruziziensis cross-compatible with B. decumbens and B. brizantha. Applied Brachiaria breeding projects are underway both in Colombia (International Center for Tropical Agriculture, CIAT) and Brazil (National Centre for Beef Cattle Research - Brazilian Corporation for Agricultural Research, CNPGC/EMBRAPA). These seek to combine the broad edaphic adaptation and other desirable agronomic attributes of B. decumbens cv. Basilisk with spittlebug resistance. An …

Persistency In Lolium X Festuca Hybrid Derivatives And Its Relationships With Flowering Traits, M Ghesquiere, C Mousset

IGC Proceedings (1977-2023)

Using amphiploid and backcrossed derivatives of Italian ryegrass x tall fescue hybrids, the paper emphasizes the interest of introgression vs amphiploidization in breeding for specific traits such as persistency or seed production from tall fescue or ryegrass resp. Persistency in amphiploid and Lolium-introgressed progenies were assessed in nursery together with variation of flowering traits. Persistency was found lower, on average, in introgressed progenies than in hybrid progenies but with enlarged variability within progeny suggesting possible advantageous rearrangements of fescue chromosomes. Although significantly associated, persistency in both populations was only very little affected by the variations in flowering traits such …

Western Science And Eastern Zen To Seek The Origin Of Truth: Philosophical Background Of Scale Modeling, Kozo Saito

Progress in Scale Modeling, an International Journal

This article was written to introduce philosophical background of scale modeling, where Zen philosophy was applied to overcome the limitation of logical thinking and hypotheses-driven deductive science. Three specific reasons are as follows. The first is related to the law approach in scale modeling; it uses the kufu principle, originated in Zen Buddhism, together with the other three scientific methods: experimental, theoretical, and computational. The second reason is because scale modeling seeks relativistic understanding by attempting to realize similarity; the concept is closer to Eastern philosophy rather than absolute understanding cultivated by deductive science. The third is in the educational …

Online Instructional Tools For Motor Carriers, Brian Howell, Jennifer Walton, Paul Ross, Andrew Martin

Kentucky Transportation Center Research Report

Commercial motor carrier customers on Kentucky highways must register and pay taxes for licensing and credentialing requirements. The Kentucky Transportation Cabinet (KYTC) provides an online Motor Carrier Portal that offers information and instructions on meeting these requirements, but customers have increasingly resorted to calling into KYTC’s motor carrier help desk, thereby straining limited personnel resources. The Kentucky Transportation Center (KTC) coordinated with KYTC to develop a series of online instructional videos that can better assist customers with applying for and meeting credentialing requirements.

KTC researchers used a three-phase approach to determine the feasibility and requirements for instructional videos. First, they …

Chinese Digital Platform Companies’ Expansion In The Belt And Road Countries, Yujia He

Patterson School of Diplomacy and International Commerce Faculty Publications

The emergence of digital platforms is shifting the digital economy toward a platform economy, and Chinese platform-based businesses like Alibaba, Tencent, and JD are increasingly expanding in the Global South. Alongside this, the Chinese government has been promoting digital economy collaboration with emerging markets through high-level engagement under the banner of the Belt and Road Initiative (BRI) and its digital economy component the Digital Silk Road (DSR). Despite significant market interest and policy attention, grounded empirical analysis of Chinese digital platforms’ expansion within Belt and Road Initiative countries is scarce. This study employs a mixed-methods approach, drawing on both quantitative …

Strengthening The Deployment Of Uncrewed Aerial Systems (Uas) At Kytc, Rachel Catchings, Suzanne Smith, Gayle Marks, Candice Wallace, Christopher Van Dyke

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) and transportation agencies around the United States increasingly depends on uncrewed aircraft systems (UAS — also commonly known as drones) to collect data and accelerate project development and delivery. Drones let transportation practitioners safely and efficiently perform many activities, including bridge and highway inspection, construction monitoring, surveying, emergency response, and measuring stockpiles. KYTC’s implementation of UAS has expanded rapidly over the past 10 years, however, the agency lacks well-coordinated procedures for connecting pilots with end data users, scheduling and conducting flights, developing and documenting best practices, and processing and storing data. Based on a review …

Best Practices For Recruitment And Retention Of Transportation Professionals, Chris Van Dyke, Bryan Gibson, Sarah Mccormack, Merl Hackbart, Doug Kreis

Kentucky Transportation Center Research Report

Many public sector agencies, including state departments of transportation (DOTs), have long found recruiting and retaining staff a daunting challenge. Lured by the promise of higher salaries in the private sector, many people are reluctant to sacrifice their long-term earnings potential to pursue public service. And with the quality of fringe benefits (e.g., retirement plans, health insurance) offered by public agencies having declined gradually, it is even more difficult to persuade prospective employees to accept a lower salary. Many studies over the past 15—20 years have looked at methods for solving the problem of recruitment and retention within the context …

Older Adults Using Social Support To Improve Self-Care (Oasis), Brittany L. Smalls, Aaron Kruse-Diehr, Courtney L. Ortz, Key Douthitt, Christopher Mclouth, Rachel Shelton, Zoe Taylor, Edith Williams

Biostatistics Faculty Publications

Introduction The prevalence of type 2 diabetes (T2D) is 17% higher in rural dwellers compared to their urban counterparts, and it increases with age, with an estimated 25% of older adults (≥ 65 years) diagnosed. Appropriate self-care is necessary for optimal clinical outcomes. Overall, T2D self-care is consistently poor among the general population but is even worse in rural-dwellers and older adults. In rural Kentucky, up to 23% of adults in Appalachian communities have been diagnosed with T2D and, of those, 26.8% are older adults. To attain optimal clinical outcomes, social environmental factors, including social support, are vital when promoting …