Digital Commons Network^™

Disrupted Calcium Dynamics In Reactive Astrocytes Occur With End Feet–Arteriole Decoupling In An Amyloid Mouse Model Of Alzheimer’S Disease, Blaine Weiss, John C. Gant, Ruei-Lung Lin, Jenna L. Gollihue, Colin B. Rogers, Susan D. Kraner, Edmund B. Rucker, Yuriko Katsumata, Yang Jiang, Peter T. Nelson, Donna M. Wilcock, Pradoldej Sompol, Olivier Thibault, Christopher M. Norris

Sanders-Brown Center on Aging Faculty Publications

While cerebrovascular dysfunction and reactive astrocytosis are extensively characterized hallmarks of Alzheimer's disease (AD) and related dementias, the dynamic relationship between reactive astrocytes and cerebral vessels remains poorly understood. Here, we used jGCaMP8f and two-photon microscopy to investigate calcium signaling in multiple astrocyte subcompartments, concurrent with changes in cerebral arteriole activity, in fully awake 7- to 8-month-old male and female 5xFAD mice, a model for AD-like pathology, and wild-type (WT) littermates. In the absence of movement, spontaneous calcium transients in barrel cortex occurred more frequently in astrocyte somata, processes, and perivascular regions of 5xFAD mice. However, evoked arteriole dilations (in …

How Grand Jury Secrecy And Bias Protects And Perpetuates Police-Suspect Impunity, Ilana M. Friedman

Law Faculty Scholarly Articles

This Article proceeds in four parts. Part I introduces the theoretical frameworks for various questions involving police-suspect grand juries, including the structure and function of contemporary grand juries, the law surrounding examinations into an officer’s use of force, modern prosecutorial influences, findings from social psychologists on the impacts of diversity on jury decision-making practices, and how police-suspect grand juries implicate unique political pressures.

Part II presents a description of original methods of data collection. To investigate this setting, forty-seven in-depth, semi-structured interviews with twenty-one respondents in five field sites around the country was conducted. Respondents included civilians and legal

professionals …

History, Tradition, And Voter Registration, Joshua A. Douglas

Law Faculty Scholarly Articles

History and tradition are dominating the Supreme Court, which has invoked history and tradition to curtail some rights, such as abortion, while using it to elevate other rights, such as the right to bear arms. Might history and tradition also cause the Court to strike down new restrictions on the right to vote, even if doing so would cut against the current Court’s narrow protection of voting rights? Disputes over voter registration restrictions will pose that very question. Many states have recently implemented onerous rules on voter registration, especially targeting third-party voter registration organizations. Congress is also debating the SAVE …

The Case Against Surge Pricing, Ramsi A. Woodcock

Law Faculty Scholarly Articles

Surge pricing—using data and algorithms to raise prices in response to unexpected increases in demand—has spread across the economy in recent years, from Amazon and Disney World to commuter highways and, of course, Uber, which is infamous for surge pricing rides. Companies claim that surge pricing equilibrates supply and demand, but that is impossible, at least in the short run when demand unexpectedly outstrips supply. What surge pricing really does is to ration existing supply based on ability to pay. That is both distributively unjust and potentially inefficient. It should also be considered a violation of the antitrust laws because …

The Migration Of Abolition Theory, Matthew Boaz

Law Faculty Scholarly Articles

This Article considers whether and how theories of abolition developed by criminal law scholars are transferrable to the realm of immigration enforcement. A key question is how abolitionist principles might be employed in support of critiques of the United States’ immigration regulatory regime in the same way that these principles have been deployed in denouncing racialized policing and an injurious, industrialized prison system.

This Article makes two contributions: First, it identifies and illuminates a methodology adopted by critical and decarceral criminal law scholars: (i) denouncing the harms of a structural system, (ii) identifying the normative justification(s) for this system, and …

Adapting A Mobile Health Intervention To Improve Prep Adherence Among Young Black Msm In Fulton County, Georgia, Kassidy Maust

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Young Black men who have sex with men (YBMSM) in the southern United States, particularly in Fulton County, Georgia, face disproportionately high rates of HIV and unique structural barriers to pre-exposure prophylaxis (PrEP) uptake and adherence. Sustained adherence among YBMSM remains low due to intersecting structural, social, and behavioral barriers. To address these disparities, this paper presents an adapted implementation of the evidence-based M-Cubed (Mobile Messaging for Men) mHealth intervention. Prior studies of M-Cubed and similar mHealth interventions have shown promising outcomes in increasing PrEP adherence among Black MSM populations. The adapted intervention integrates culturally tailored messaging specific to behaviors …

Air Pollution Exposures And Cognitive Function Among Older Americans, Clarisse Nyondo Okoma

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background: New findings indicate that environmental factors, such as air pollution, could contribute to cognitive decline among older adults. Nonetheless, extensive longitudinal studies in the U.S. investigating this connection are few and far between.

Objective: This study assessed the relationship between long-term exposure to ambient air pollutants and cognitive function in older adults in the United States.

Methods: We examined data from the Health and Retirement Study (2010-2018), which included 234,250 observations from adults aged 50 and older. Cognitive performance was evaluated based on immediate and delayed word recall, a 27-point cognitive summary score, backward from 20, and …

Implementing An Opioid Overdose Education And Naloxone Distribution (Oend) Program Among Law Enforcement Officers In Lee County, Ky, Keelie Jolly

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

This grant proposal describes an implementation strategy for introducing an OEND training program among law enforcement officers (LEOs) to reduce opioid overdose deaths. The goal of the project is to increase LEOs' awareness and knowledge of opioid overdose and Naloxone administration and usage of Naloxone.

Improving End-Of-Life Care: A Nursing Education Initiative, Spring C. Kingsley

DNP Projects

Background: This study addresses the gap in education and training for medical intensive care unit (MICU) nurses regarding the care of hospice patients. The traditional medical model of healthcare prioritizes illness treatment, often leading to inadequate end-of-life support and increased hospitalization during patients' final days. The rise of in-hospital hospice programs, or scatter-bed hospice models, highlights the need for nurses to enhance their skills in providing end-of-life compassionate care. The MICU at the University of Kentucky’s Chandler Hospital serves as a focal point for this initiative, given its role in caring for critically ill patients who require hospice attention.

Purpose: …

Pathogen Surveillance Of Viruses And Antimicrobial Resistance Through Wastewater Based Epidemiology, William Strike

Theses and Dissertations--Biomedical Engineering

Pandemic surveillance is a cornerstone in public health safety, as it enables identification of pathogens circulating within a community before they become widespread outbreaks. Wastewater based epidemiology has blossomed in recent years due to its success in the SARS-CoV-2 pandemic, but this form of public health surveillance has a global equity problem. A large majority of the wastewater-based surveillance work has been done in large metropolitan cities with access to advanced testing infrastructure, which poses a challenge as we consider where pandemics have historically emerged. Therefore, there is a need to identify, adapt, and develop workflows to meet the needs …

Earthquake Wrangler: Leveraging Ios Technology For Earthquake Detection And Early Warning Application To Enhance Public Safety., Luis F. Salome

Theses and Dissertations--Civil Engineering

Earthquakes are devastating natural phenomena and generate secondary hazards such as tsunamis, landslides and fires. Their catastrophic impacts span both developed nations including the United States, Japan, Turkey, and Italy and developing countries such as El Salvador, Haiti, Nepal and the Philippines, where disparities in early warning infrastructure remain important. Seismic events start with stress waves generated by tectonic plate motion, with body waves (P- waves and S-waves) and surface Rayleigh and love waves that carry energy through the earth. While some regions have adopted advanced early warning systems based on seismic hazard models and strong ground motion analysis, others …

Augmenting Machine Learning Technique Through Natural Language, Tasmia Tasrin

Theses and Dissertations--Computer Science

While artificial intelligence (AI) and machine learning (ML) have proven effective at addressing many of the challenges that we face in our everyday lives, there are many situations in which these methods struggle. Examples include environments where AI or ML systems must perform complex behaviors or those where rewards are difficult to calculate. To address this limitation, interactive machine learning (IML) techniques have been introduced, which incorporate machine-understandable human feedback into traditional ML approaches. This feedback is often given as a discrete, positive or negative numeric value. This feedback is typically provided as often as possible to convey a dense …

Preserving Nature: Mapping Patriarchal And Imperial Control In Victorian Fiction, Hannah Schultz

Theses and Dissertations--English

In Thomas Hardy’s Tess of the D’Urbervilles, a group of fallen women see “themselves and surrounding nature forming an organism of which all the parts harmoniously and joyously interpenetrated each other” (65). As relational, boundary-dissolving, ecological subjects, these women are empowered above society’s judgment, made “sublime as the moon and stars” (65). By analyzing such representations of ecological relationality in Victorian fiction, my dissertation reveals new forms of agency for women and racialized others. While many ecofeminists have historically disavowed the nature-gender link as reinforcing the shared oppression of nature and marginalized groups, I depart from this standpoint, as …

Fatal Futures: Slow Violence, Utopia, And The Postnatural Human In Contemporary American Literature, Shelby Roberts

Theses and Dissertations--English

Fatal Futures: Slow Violence, Utopia, and the Postnatural Human in Contemporary American Literature investigates the ways in which ideas of futurity are articulated in narratives that conceptualize both the end of the world and post-calamity society through the lens of a pessimistic, queer approach to understanding the future. The purpose of this project is to not only build previous research in the configurations of the body in queer, gothic, and speculative American writing as a whole, but to enter into a developing conversation surrounding Appalachian literature through the idea of kinship (the broadening of relationships both chemical and postnatural) as …

Lust, Labor, & Legitimacy: Visibility And Precarity In Platformed Sex Work, Sable J. Augustyn

Theses and Dissertations--Geography

This thesis examines the labor of platformed sex workers, positioning their experiences as a site for understanding the entanglement of multiple intersecting economies. Through qualitative interviews, it explores how sex workers navigate platform infrastructures, manage audience engagement, and contend with visibility as both an economic necessity and a site of risk. Drawing on theories of emotional labor, visibility labor, and platform governance, the project highlights how sex work on digital platforms is shaped by overlapping systems of economic extraction, technological constraint, and cultural regulation. Platformed sex work emerges here as a layered and context-specific practice—embedded within creator ecologies, attraction economies, …

Spatializing The Tax Code: Using Property Records To Locate The Fiscal Face Of Rentiership, Michael J. Mccanless

Theses and Dissertations--Geography

This dissertation analyzes how the tax code shapes housing financialization in mid-sized US cities. Employing a mixed-methods approach that integrates critical computational analysis with qualitative fieldwork in Memphis, I examine the role of public rent-seeking in shaping housing financialization in U.S. cities. The first article analyzes the property tax appeal strategies of corporate landlords and their implications for public revenues and municipal budgets. The second article explores how the IRS 1031 exchange provision—which allows for capital gains deferrals when the proceeds of a property sale are reinvested in a ‘like-kind’ property—facilitates the movement of capital from high-cost coastal markets into …

The Houston Climate Justice Museum As A Catalyst For Environmental Justice: Exploring The Intersection Of Art, Activism, And Creative Placemaking In Houston, Texas, Aylin Castro

Theses and Dissertations--Geography

This thesis explores how the Houston Climate Justice Museum (HCJM) functions as a site for environmental/climate justice education through art and community engagement. Drawing on interviews, participant observation, and document analysis, this research examines how the museum’s curating practices generate new understandings of environmental in/justices, fosters local partnerships, and creates a welcoming space for community dialogue. Findings show that the HCJM does more than exhibit art, it demonstrates how art can be leveraged to advance both activist and educational projects. This study positions the HCJM as a model for how local and justice orientated museums and cultural spaces can contribute …

Yaoi Lesbians: Media, Identity, And Desire, Olivia Marquardt

Theses and Dissertations--Linguistics

Media consumption reflects aspects of identity while also assisting in identity formation (Koller, 2008; Zemmels, 2012; Wu, 2006). This thesis examines the phenomenon of lesbians who engage with men-loving-men (MLM) media. The practice seems odd due to the contrast of lesbians desiring women for their social, platonic, romantic, and sexual relationships, but this thesis finds that repeated consumption of media that display men and their desires can index lesbianism. This practice helps lesbians construct their identities through three processes of indexicality: indexical disjuncture, indexical bleaching, and indexical denial (Barrett & Hall, 2024). Through a discourse analysis of five semi-constructed interviews …

Trashing Gender Scripts: Indexical Misrecognition In The Zine "Galatea's Naked", Jules Blank

Theses and Dissertations--Linguistics

Zines, short for ‘fanzines’ or ‘magazines,’ refer to physical, printed, self-published creations that can consist of a single sheet of paper or many, fastened together. These artifacts are rich with meaning—and, thus, can be read as tangible manifestations of the ideologies and identities of the creator(s).

This thesis focuses on the way zines are used as tools of resistance. Additionally, it shows that the creation and circulation of zines are highly pragmatic acts that solidify social bonds and enable individuals to perform and reinforce their emergent identities within a collective—explicitly making a claim about who they are and what they …

Cognate Facilitation And Processing In English-Speaking Learners Of German, Kaitlin L. Young

Theses and Dissertations--Linguistics

Within the field of second language acquisition, research finds that increased exposure to input results in improved proficiency, especially when those activities are challenging yet manageable for the language learner’s current level. Because of this, listening exercises and speech processing are considered integral to language acquisition, even leading to recommendations of frequent, authentic use of the target language (TL). Instructors’ TL authenticity is, however, sometimes stunted by the demand for comprehensible input and facilitation of classroom activities; they make use of simpler syntax, stronger enunciation, and more cognates (words sharing origins, meanings, and form across languages) than in casual speech. …

Orthographic Errors For Dysgraphic Second Language Learners In Russian And Hebrew, Kyra O. Morgan

Theses and Dissertations--Linguistics

Students of Second Languages might be asked to learn new writing systems in the classroom. This study is interested in how dysgraphic students, that is, students with a specific learning impairment with regards to written expression, make errors in comparison to their peers. These errors revolve around orthography, spelling, and spacing. However, this study will take a turn and focus on how all of the respondents understood the prompt and what that says about their relationship with writing in the classroom.

Hugo Chávez, El Camino Hagiográfico: Religión Y Bolivarianismo En La Construcción Discursiva Del Culto A Un Presidente, Lilia Malavé Conley

Theses and Dissertations--Hispanic Studies

This dissertation examines the discursive construction of the political-religious cult surrounding Hugo Chávez through a theoretical and methodological approach that integrates Critical Discourse Analysis (CDA) and Multimodal Discourse Analysis (MDA). Its central objective is to identify and interpret the incorporation of elements from the Venezuelan religious imaginary–particularly from popular Christianity–into the symbolic configuration of Chávez as a sacred figure within official discourse. The corpus analyzed includes official transcripts from the television program Aló Presidente, as well as two animated short films titled Chávez Nuestro que Estás en el Cielo (“Our Chávez Who Art in Heaven”), broadcast on Venezuelan public …

Two Network Flow Problems: Volume Inequalities For Flow Polytopes Of Full Directed Acyclic Graphs; Optimal Additions To The Low-Stress Bike Network In Lexington, Kentucky, James F. Mcelroy

Theses and Dissertations--Mathematics

This dissertation addresses two distinct problems related by their foundation in network flows. The first problem concerns volumes of flow polytopes of directed acyclic graphs with out-degree sequence (3,2,...,2,0). It is proved that there is an interchange operation on the edge set of these graphs that induces a partial order on the graphs isomorphic to a Boolean algebra, and that moving up through this partial order decreases (weakly) the volumes of the corresponding flow polytopes. This result is reinterpreted in the context of linear extensions for posets that are bipartite non-crossing trees.

The second problem develops a discrete optimization model …

Applied Essays In Industrial Organization: Pricing In Short-Term Rental Markets And Policy Implications In Tobacco Consumption, Richard J. Applin

Theses and Dissertations--Economics

Economics 101 teaches that the interaction between supply and demand determines the prices and quantities consumers face. In econometric research, it is critical to remain aware of this canonical fact, as failure to do so can introduce bias in the estimation of economic parameters. This dissertation empirically demonstrates the importance of factoring in economic structure in three applied essays.

In the first essay, I estimate the impact of rating visibility on Airbnb pricing using a two-way fixed effects model. To do so, I primarily rely on an instrumental variables approach that I argue should identify a supply-side relationship. I provide …

Three Essays On The Impacts Of Pollution, Isaiah Chapman Bryant Sheth

Theses and Dissertations--Economics

My dissertation is broadly focused on using data to quantify the consequences of pol- lution and is organized into three chapters. Chapter one estimates the effect on infant health of drinking water contamination attributable to tropical cyclones. Chapter two examines the heterogeneous effects of a policy aimed at reducing air pollution based on pre-existing air quality conditions. Lastly, chapter three investigates how regula- tions aimed at shaping housing development to minimize climate risk impacted the housing market in Houston Texas. Each of these chapters considers different con- sequences of pollution, from direct health costs of pollution exposure to secondary effects …

Cellular And Behavioral Consequences Of Psychedelic Drug Action In The Claustrum, Tanner L. Anderson

Theses and Dissertations--Neuroscience

Psychedelics are rapidly garnering research attention for their ability to successfully treat a variety of psychiatric diseases after one or a handful of treatments in recent clinical research. Among the conditions treated is substance use disorder (SUD), which afflicted 48.5 million (16.7%) Americans aged 12 and older in 2023 (NSDUH). As clinical trial results continue to show lasting positive effects of psychedelic psychotherapy, there remains an enormous gap in knowledge regarding how these drugs cause lasting changes in the brain to achieve these therapeutic effects. It has been suggested that psychedelics must induce rapid and long-lasting neuronal plasticity in order …

Leveraging Clinical Standards To Improve The Translational Relevance Of Therapies For Experimental Spinal Cord Injury, Aaron L. Silverstein

Theses and Dissertations--Neuroscience

Efforts to improve treatment of spinal cord injury (SCI) often use animals to develop effective therapeutics, intending to improve the survival and the quality of life of persons with SCI. Over half of all SCIs in the United States occur at the cervical level and often cause locomotor deficits and life-threatening breathing dysfunction. Thus, my dissertation is focused on this important patient population.

After beginning with a description of translational research and surveying SCI from a clinical standpoint, I turned to describe experimental models of cervical SCI and more detailed neuroimmunological findings relevant to my work. Then, I conducted a …

Changes In Cancer Diagnosis And Survival In The United States During The Covid-19 Pandemic, Justin T. Burus

Theses and Dissertations--Epidemiology and Biostatistics

The COVID-19 Pandemic led to global societal disruptions as political leaders and public health authorities attempted to control the spread of the newly discovered SARS- CoV-2 virus. While these measures were designed to lessen morbidity and mortality from a novel pathogen, their impact was also felt in many other, often unintended ways. The purpose of this dissertation is to use cancer surveillance research methods to examine the association between COVID-19 Pandemic-related disruptions and changes in the normal diagnosis and care of cancer in the United States.

The first two studies of this dissertation analyzed reductions in cancer diagnoses in the …

Towards A Sociological Theory Of Consent And Coercion In Sexual Violence Against Women, Lisa Kistler

Theses and Dissertations--Sociology

Recent data estimate that 26.8% of adult women in the U.S. have experienced rape in their lifetime. In this context, the phrase “consent to sex” is a prominent narrative countering sexual violence. Yet, there is no consensus on the meaning of consent, nor how the practice of consent is affected by coercion, resulting in a puzzle of consent. In response, the present project brings together existing research and theory to conceptualize consent and coercion in new ways. It asks, broadly, how do different forms of coercion complicate sexual consent and contribute to sexual violence against women today and answers this …

A Comprehensive Exploration Of Stress And Depressive Symptoms In Farm Populations, Julie C. Derringer

Theses and Dissertations--Nursing

High rates of depression and suicide continue to be a concern, despite four decades of growing research into the mental health of farmers. Most farmers have an awareness of a need for improved mental health, but a lack of knowledge persists. As agricultural production demands increase and the number of family farms decreases, the stress placed upon farmers to support the food chain is higher than ever. Understanding the association between farm demands and resources among farmers is key for the development and implementation of programs to decrease occupational stress and depressive symptoms to improve mental health outcomes across farming …