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Articles 331 - 360 of 10381
Full-Text Articles in Entire DC Network
Do Communities Implementing The Communities That Heal Intervention Have Significantly Lower Rates Of High-Risk Opioid Prescribing And Dispensing?, Frances R. Levin, Douglas R. Oyler, Denise C. Babineau, Jennifer Villani, Redonna K. Chandler, Patricia R. Freeman, Daniel P. Alford, Naleef Fareed, Nicole Mack, Trang Q. Nguyen, Daniel M. Walker, Joella Adams, Trevor J. Baker, Donna Beers, Shoshana N. Benjamin, Jennifer Bhuiyan, Derek Blevins, James L. David, Netrali Dalvi, Lauren D'Costa, Daniel J. Feaster, La Shawn Glasgow, Dawn A. Goddard-Eckrich, Yi Han, Mallory Harris, Timothy Hunt, Charles Knott, Adrienne Matson
Do Communities Implementing The Communities That Heal Intervention Have Significantly Lower Rates Of High-Risk Opioid Prescribing And Dispensing?, Frances R. Levin, Douglas R. Oyler, Denise C. Babineau, Jennifer Villani, Redonna K. Chandler, Patricia R. Freeman, Daniel P. Alford, Naleef Fareed, Nicole Mack, Trang Q. Nguyen, Daniel M. Walker, Joella Adams, Trevor J. Baker, Donna Beers, Shoshana N. Benjamin, Jennifer Bhuiyan, Derek Blevins, James L. David, Netrali Dalvi, Lauren D'Costa, Daniel J. Feaster, La Shawn Glasgow, Dawn A. Goddard-Eckrich, Yi Han, Mallory Harris, Timothy Hunt, Charles Knott, Adrienne Matson
Biostatistics Faculty Publications
Introduction: Prescription opioids can contribute to risk for opioid use disorder and overdoses. Improving prescription opioid safety is a critical component in reducing opioid risks. This report aims to determine whether communities randomized to the Communities That HEAL (CTH) intervention have significantly different rates of prescription opioid safety measures. Study Design: A multisite, 2-arm, community-level, cluster randomized, unblinded, wait-list controlled comparison trial designed to assess the effectiveness of the CTH intervention in reducing opioid-related overdose deaths among community residents 18 years of age or older (adults). Setting/Participants: Sixty-seven (67) communities in Kentucky, Massachusetts, New York, and Ohio. “Participants” were communities …
Emergence Of Inflammatory Fibroblasts With Aging In Hermansky-Pudlak Syndrome Associated Pulmonary Fibrosis, Brandon J.H. Banaschewski, Sylvia N. Michki, Sneha Sitaraman, Ruby Pan, Joanna Y. Wang, Dominique Stewart, Mary Kate Goldy, Susan M. Lin, Edward Cantu, Jeremy B. Katzen, Maria C. Basil, Amir M. Emtiazjoo, Jamie L. Todd, Jason J. Gokey, Jonathan A. Kropski, David B. Frank, Jarod A. Zepp, Lisa R. Young
Emergence Of Inflammatory Fibroblasts With Aging In Hermansky-Pudlak Syndrome Associated Pulmonary Fibrosis, Brandon J.H. Banaschewski, Sylvia N. Michki, Sneha Sitaraman, Ruby Pan, Joanna Y. Wang, Dominique Stewart, Mary Kate Goldy, Susan M. Lin, Edward Cantu, Jeremy B. Katzen, Maria C. Basil, Amir M. Emtiazjoo, Jamie L. Todd, Jason J. Gokey, Jonathan A. Kropski, David B. Frank, Jarod A. Zepp, Lisa R. Young
Surgery Faculty Publications
The longitudinal cellular interactions that drive pulmonary fibrosis are not well understood. To investigate the disease underpinnings associated with fibrosis onset and progression, we generated a scRNA-seq atlas of lungs from young and aged mouse models of multiple subtypes of Hermansky-Pudlak syndrome (HPS), a collection of rare autosomal recessive diseases associated with albinism, platelet dysfunction, and pulmonary fibrosis. We have identified an age-dependent increase in SAA3+ inflammatory lung fibroblasts in HPS mice, including in double-mutant HPS1-2 mice which develop spontaneous fibrosis. HPS1 fibroblasts show increased expression of IL-1R1, whereas alveolar type II epithelial cells from HPS2 mice induce the …
Genomic, Transcriptomic, And Immunogenomic Landscape Of Over 1300 Sarcomas Of Diverse Histology Subtypes, Alex Soupir, Oscar E. Ospina, Oliver Hampton, Michelle Churchman, Michael Radmacher, Dale Hedges, David Mckean, Phaedra Agius, Saman Zeeshan, Nathan D. Seligson, Raphael Pollock, David Liebner, James L. Chen, Gabriel Tinoco, Bodour Salhia, Martin Mccarter, Breelyn A. Wilky, Benjamin J. Miller, Michael J. Cavnar, John S. Groundland, Bryan P. Schneider, Gregory Riedlinger, Stephen B. Edge, Christopher A. Moskaluk, Kenneth Cardona, Abdul Rafeh Naqash, Ricardo J. Gonzalez, John E. Mullinax
Genomic, Transcriptomic, And Immunogenomic Landscape Of Over 1300 Sarcomas Of Diverse Histology Subtypes, Alex Soupir, Oscar E. Ospina, Oliver Hampton, Michelle Churchman, Michael Radmacher, Dale Hedges, David Mckean, Phaedra Agius, Saman Zeeshan, Nathan D. Seligson, Raphael Pollock, David Liebner, James L. Chen, Gabriel Tinoco, Bodour Salhia, Martin Mccarter, Breelyn A. Wilky, Benjamin J. Miller, Michael J. Cavnar, John S. Groundland, Bryan P. Schneider, Gregory Riedlinger, Stephen B. Edge, Christopher A. Moskaluk, Kenneth Cardona, Abdul Rafeh Naqash, Ricardo J. Gonzalez, John E. Mullinax
Surgery Faculty Publications
Given their rarity and diversity, a fundamental understanding of the genomic underpinnings for many sarcoma subtypes is still lacking. To better define the molecular landscape of this group of diseases, we perform matched whole exome sequencing and RNA sequencing on a cohort of 1340 sarcoma tumor specimens. We identify recurrent somatic mutations and observe an increased mutational burden in metastatic vs. primary samples (p < 0.001). We observe frequent copy number alterations including whole genome doubling, with this feature being more common in metastatic tumors (p = 0.026). Estimation of immune cell abundances followed by hierarchical clustering identifies five immune subtypes ranging from low to high and we observe inferior overall survival in immune deplete clusters compared to immune enriched (p < 0.01). Interestingly, GIST predominantly form a distinct “immune intermediate” cluster that is marked by a specific enrichment for NK cells (FDR < 0.01).
Mir-181a-5p Mediates The Effects Of Bmp4 On Intestinal Cell Proliferation And Differentiation, Chang Li, Yuning Zhou, Zhijie Yin, Yinping Jiang, Jinpeng Liu, Heidi L. Weiss, Qingding Wang, B. Mark Evers
Mir-181a-5p Mediates The Effects Of Bmp4 On Intestinal Cell Proliferation And Differentiation, Chang Li, Yuning Zhou, Zhijie Yin, Yinping Jiang, Jinpeng Liu, Heidi L. Weiss, Qingding Wang, B. Mark Evers
Surgery Faculty Publications
The intestinal mucosa undergoes a dynamic process of continual proliferation, differentiation, and apoptosis. Delineating the mechanisms involved in intestinal epithelial cell (IEC) differentiation is crucial to our understanding of not only normal gut adaptation but also aberrant intestinal growth. Bone morphogenetic protein (BMP) signaling is a pivotal regulator of intestinal proliferation and differentiation. However, the molecular underpinnings of the BMP pathway in this context are not entirely known. Here, we show a key role for the BMP4/microRNA (miR)-181/glycolysis signaling pathway in the maintenance of intestinal epithelial cell proliferation and differentiation. Treatment with BMP4 increased the expression of enterocyte markers and …
Hiring Expectations For New And Future Workers In Animal Genetics Careers, Meghan C. Wulster-Radcliffe, James N. Macleod, Robert J. Coleman, John S. Radcliffe, Rebekah B. Epps, Carol D. Hanley, Cheyenne S. Summers, Steven A. Zinn, Sarah A. Reed
Hiring Expectations For New And Future Workers In Animal Genetics Careers, Meghan C. Wulster-Radcliffe, James N. Macleod, Robert J. Coleman, John S. Radcliffe, Rebekah B. Epps, Carol D. Hanley, Cheyenne S. Summers, Steven A. Zinn, Sarah A. Reed
Animal and Food Sciences Faculty Publications
To better align educational outcomes with workforce demands in animal and equine genetics, this study surveyed 65 industry professionals on entry-level competencies, hiring trends, and graduate preparedness of undergraduate students. The survey assessed employer ratings on the importance and perceived proficiency of seven core competencies: critical thinking, communication, teamwork, leadership, professionalism, career/self-development, and equity/inclusion, as well as technical knowledge and broader skills relevant to animal breeding and genetics. Results revealed oral communication, teamwork, and work ethic were rated as the most critical transferable skills, though notable proficiency gaps persist, particularly in leadership and professionalism. Foundational technical knowledge in genetics, molecular …
Trajectories Of Recovery After Acute And Critical Illness (Tracer), Felipe González-Seguel, Louisa A. Summers, Lindsey E. Fresenko, Douglas E. Long, Logan N. Scott, Stacey A. Slone, Srushan Shankara Bhaktula, Yuan Wen, Benjamin F. Miller, Peter E. Morris, Amy L. Salyer, Anna G. Kalema, Ashley A. Montgomery-Yates, Esther E. Dupont-Versteegden, Kirby P. Mayer, Isabelle D. Bach, Davis A. Englund, Zachary R. Hettinger, Ahmed Ismaeel, Audrey M. Johnson, Philip A. Kern, Gerald V. Klim, Allison M. Owen, Jocelyn C. Porchia, Heba H. Qaissi
Trajectories Of Recovery After Acute And Critical Illness (Tracer), Felipe González-Seguel, Louisa A. Summers, Lindsey E. Fresenko, Douglas E. Long, Logan N. Scott, Stacey A. Slone, Srushan Shankara Bhaktula, Yuan Wen, Benjamin F. Miller, Peter E. Morris, Amy L. Salyer, Anna G. Kalema, Ashley A. Montgomery-Yates, Esther E. Dupont-Versteegden, Kirby P. Mayer, Isabelle D. Bach, Davis A. Englund, Zachary R. Hettinger, Ahmed Ismaeel, Audrey M. Johnson, Philip A. Kern, Gerald V. Klim, Allison M. Owen, Jocelyn C. Porchia, Heba H. Qaissi
Physiology Faculty Publications
Introduction Patients who survive admission to intensive care unit (ICU) for critical illness are at high risk of developing muscle atrophy and weakness, commonly diagnosed as ICU-acquired weakness (ICUAW). The development of ICUAW is closely linked to long-term symptoms and impairments known as post-intensive care syndrome (PICS). Despite heightened recognition of impairments, there is limited research supporting effective interventions to improve muscle and physical outcomes after hospital discharge. Prior to developing and testing interventions for ICU survivors, it is imperative to understand the trajectory of muscle and physical function recovery following an ICU stay. The purpose of this study is …
Introducing Neuro Social Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa
Introducing Neuro Social Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa
Social Work Faculty Publications
Neuroscience offers language and evidence that can strengthen interdisciplinary communication, support advocacy in biomedically dominated settings, and validate relational practices long recognized in social work, including the impacts of early adversity, attachment, and healing through connection. At the same time, an epistemological tension underlies the profession’s unease with neuroscience when brain-based narratives are used to individualize structural harm or justify surveillance of marginalized families and communities. This teaching note introduces Neuro Social Work as a justice-oriented specialization that integrates contemporary neuroscience with social work’s person-in-environment commitments, relational practice traditions, and anti-oppressive ethics.The author argues that the key question is no …
Introducing Neuro Sscial Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa
Introducing Neuro Sscial Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa
Social Work Faculty Publications
This reflection introduces and contextualizes the term Neuro Social Work, which I coin to name a specialized practice area at the intersection of social work, neuroscience, and neurodiversity. Drawing on my experience as a social work educator and practitioner, I discuss social work’s uneasy relationship with neuroscience, marked both by the opportunity to deepen our understanding of trauma, development, and healing, and by the risks of using brain‑based evidence to individualize structural harms or justify surveillance of marginalized communities. I outline, in broad strokes, what distinguishes Neuro Social Work from general neuroscience‑informed practice. The note is intended as a concept …
Redistricting, Gerrymandering, And Graham V. Adams: It's Time For An Independent Redistricting Commission In Kentucky, Kathleen Dudgeon
Redistricting, Gerrymandering, And Graham V. Adams: It's Time For An Independent Redistricting Commission In Kentucky, Kathleen Dudgeon
Kentucky Law Journal
No abstract provided.
"Blocking Out The Haters:" Government Officials Create Split Among Federal Judiciary, Andrew Weisgerber
"Blocking Out The Haters:" Government Officials Create Split Among Federal Judiciary, Andrew Weisgerber
Kentucky Law Journal
No abstract provided.
The Next Generation, Jeremiah Chin
Governors Slightly More Bound? A Critique Of The Uniform Law Commission's Model Public-Health Emergency Authority Act, Paul A. Diller
Governors Slightly More Bound? A Critique Of The Uniform Law Commission's Model Public-Health Emergency Authority Act, Paul A. Diller
Kentucky Law Journal
No abstract provided.
Protecting Public Employees' Free Speech: It's Time For The Sixth Circuit To Take Action, Faith O. Turner
Protecting Public Employees' Free Speech: It's Time For The Sixth Circuit To Take Action, Faith O. Turner
Kentucky Law Journal
No abstract provided.
The End Of An Aberration: Overturning Major League Baseball's Century-Old Antitrust Exemption, Jacob Baird
The End Of An Aberration: Overturning Major League Baseball's Century-Old Antitrust Exemption, Jacob Baird
Kentucky Law Journal
No abstract provided.
Ductile Rights, W. C. Bunting
Demonstrating Civility: A Law School Learning Outcome, Laurel Rigertas
Demonstrating Civility: A Law School Learning Outcome, Laurel Rigertas
Kentucky Law Journal
No abstract provided.
The Myth Of Fundamental Decisions, Michael D. Cicchini
The Myth Of Fundamental Decisions, Michael D. Cicchini
Kentucky Law Journal
No abstract provided.
The First Amendment, Discrimination, And Public Accommodations At Common Law, Adam J. Macleod
The First Amendment, Discrimination, And Public Accommodations At Common Law, Adam J. Macleod
Kentucky Law Journal
No abstract provided.
The Paradox Of Barring Early-Release Defendants From Section 1983 Relief, Emily M. Puckett
The Paradox Of Barring Early-Release Defendants From Section 1983 Relief, Emily M. Puckett
Kentucky Law Journal
No abstract provided.
Disproportionate School Brutality Upon Black Children, Nicole Tuchinda
Disproportionate School Brutality Upon Black Children, Nicole Tuchinda
Kentucky Law Journal
No abstract provided.
Avoid The Proxy: It's Time For Congress To Wager On Sports Betting, Andrew Tao
Avoid The Proxy: It's Time For Congress To Wager On Sports Betting, Andrew Tao
Kentucky Law Journal
No abstract provided.
Redistricting's Ultimate Antidote, Douglas M. Spencer
Redistricting's Ultimate Antidote, Douglas M. Spencer
Kentucky Law Journal
No abstract provided.
The Phantasm Of Principle, Wilfred U. Codrington Iii
The Phantasm Of Principle, Wilfred U. Codrington Iii
Kentucky Law Journal
No abstract provided.
Apoe-Targeted Therapeutics For Alzheimer’S Disease, Hussein N. Yassine, Cristelle Hugo, Bernadette O’Donovan, Isaiah O. Stephens, Lance A. Johnson, Gregory Cole, Julia Tcw, Jan Johansson, Kassandra Kisler, Ornit Chiba-Falek
Apoe-Targeted Therapeutics For Alzheimer’S Disease, Hussein N. Yassine, Cristelle Hugo, Bernadette O’Donovan, Isaiah O. Stephens, Lance A. Johnson, Gregory Cole, Julia Tcw, Jan Johansson, Kassandra Kisler, Ornit Chiba-Falek
Physiology Faculty Publications
Apolipoprotein E (APOE) is the major lipid transport protein in the brain. Produced primarily by astrocytes and microglia, it delivers cholesterol and other lipids for membrane repair, synaptic maintenance, and immune regulation. Through interactions with specific lipid receptors, APOE maintains neuronal and vascular health. The APOE ε4 allele (APOE4), carried by approximately one-quarter of the population, has an altered protein conformation, which reduces lipid transport efficiency and modifies receptor binding. These changes disrupt lipid homeostasis, increase risk of chronic unresolved neuroinflammation and vascular inflammation, and cause breakdown of the blood–brain barrier (BBB), thus increasing neuronal vulnerability to disease pathology and …
The Interpretive Foundations Of Arbitrary Or Capricious Review, Alexander Mechanick
The Interpretive Foundations Of Arbitrary Or Capricious Review, Alexander Mechanick
Kentucky Law Journal
No abstract provided.
Age Is More Than Just A Number: A Legal And Ethical Defense Of Age-Based Triage Protocols, Jessica Mantel
Age Is More Than Just A Number: A Legal And Ethical Defense Of Age-Based Triage Protocols, Jessica Mantel
Kentucky Law Journal
No abstract provided.
The Solutions Lies In Prevention: How Implementing Preventative Human Trafficking Education Into Public High Schools Is The Key To Abolishing Human Trafficking, Rachael Beller
Kentucky Law Journal
No abstract provided.
Equality Can Stick With Bostock: A Call To Expand The Equal Protection Clause To Include Discrimination Against Transgender People's Bathroom Usage, Jackson B. Hurst-Sanders
Equality Can Stick With Bostock: A Call To Expand The Equal Protection Clause To Include Discrimination Against Transgender People's Bathroom Usage, Jackson B. Hurst-Sanders
Kentucky Law Journal
No abstract provided.
Distilling The Language Of The Law, Stacey A. Tovino
Distilling The Language Of The Law, Stacey A. Tovino
Kentucky Law Journal
No abstract provided.
The S.E.C.'S Unconstitutionally Compelled Speech, Steven J. Cleveland
The S.E.C.'S Unconstitutionally Compelled Speech, Steven J. Cleveland
Kentucky Law Journal
No abstract provided.