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Building Better Partnerships: Design-Build Lessons From The Ash Pond Closure Front Lines, Brian Egan, Nicholas Golden, Mark Edlebeck May 2026

Building Better Partnerships: Design-Build Lessons From The Ash Pond Closure Front Lines, Brian Egan, Nicholas Golden, Mark Edlebeck

World of Coal Ash Proceedings

This presentation shares lessons learned on an ash pond dig-and-haul project delivered by a design-build team with CTI providing engineering and Fisher Contracting delivering construction services. CTI and Fisher Contracting will discuss how they formed their partnership, what makes a good teaming arrangement work, and the challenges that come with working closely together. This team has worked side by side from early design through construction, which has helped cut costs and keep the project on schedule. The talk will show how the partners divide tasks, then adjust roles as needed instead of locking into a fixed plan. In some cases, …


Dewatering System Operations And Modeling Of A Bottom Ash Ccr Surface Impoundment, Craig Schuettpelz, Todd Stong, Ben Sieren May 2026

Dewatering System Operations And Modeling Of A Bottom Ash Ccr Surface Impoundment, Craig Schuettpelz, Todd Stong, Ben Sieren

World of Coal Ash Proceedings

Dewatering of coal combustion residual (CCR) surface impoundments is a technically challenging item for sites with CCR units at closure. Generation has ceased at this site where fly ash was mostly sold for beneficial use and bottom ash was sluiced to composite-lined CCR surface impoundments to passively drain prior to landfilling. During site closure and restoration, bottom ash and relatively minor amounts of other permitted waste materials were consolidated into the site’s landfill and bottom ash impoundment. The bottom ash impoundment entered closure 5 years ago with installation of a final cover system and construction of a sump to allow …


Illinois Coal Ash Impoundment Assessment, Randy Locke May 2026

Illinois Coal Ash Impoundment Assessment, Randy Locke

World of Coal Ash Proceedings

Coal combustion residuals (CCR) present one of the most significant waste management challenges in the United States. Illinois hosts 72 coal ash impoundments at 23 facilities across 22 counties. In 2019, the state enacted Public Act 101 0171 (Coal Ash Pollution Prevention Act), followed by Illinois Administrative Code Title 35, Part 845, establishing CCR surface impoundment standards. Even with federal and state requirements, significant gaps remain in identifying management options and site-specific risks. Key limitations include: (1) incomplete understanding of ash composition and variability within and among impoundments; and (2) fragmented information on impoundment physical properties, operational status, and geological …


Constructed Care: Stitching Patient Journeys Through Quilting And Healthcare Design, Ashley D. Moberly May 2026

Constructed Care: Stitching Patient Journeys Through Quilting And Healthcare Design, Ashley D. Moberly

Graduate Final Projects

This thesis investigates how healthcare environments can better support patient experience through improved wayfinding, spatial clarity, and human-centered design strategies. Contemporary healthcare systems are often complex and difficult to navigate, placing additional cognitive and emotional burdens on patients, particularly those traveling from rural and underserved regions. Drawing from both professional experience in healthcare facilities planning and a comprehensive review of literature on spatial perception, wayfinding, and patient-centered care, this research identifies key challenges in how patients' access, interpret, and move through healthcare environments.

In response, the study introduces the Quilt Logic System, a conceptual framework that translates principles derived from …


From Demolition To Digital: Using Virtual Reality To Interpret Hamilton House, Hannah R. Miller May 2026

From Demolition To Digital: Using Virtual Reality To Interpret Hamilton House, Hannah R. Miller

Graduate Final Projects

This master’s project investigates the potential of digital reconstruction as a tool for documenting and interpreting demolished historic resources, using Hamilton House as a case study. Employing a mixed-methods approach, the research integrates archival analysis with digital modeling to recreate the spatial context of the house. By grounding the digital model in historical evidence, this study examines how virtual reconstruction can be used to interpret social relationships, patterns of use, and lived experiences that are not fully captured through traditional means of documentation. This project also considers the interpretive implications of reconstructing using fragmentary historical data, addressing the possibilities and …


The Modern Hydraulic Containment System: Using Automation, Telemetry And Data Dashboarding To Meet Client And Regulatory Objectives At A Coal Combustion Residual (Ccr) Site, Brian Hennings, Christopher Glidden, Vic Modeer, J. Austin Bond May 2026

The Modern Hydraulic Containment System: Using Automation, Telemetry And Data Dashboarding To Meet Client And Regulatory Objectives At A Coal Combustion Residual (Ccr) Site, Brian Hennings, Christopher Glidden, Vic Modeer, J. Austin Bond

World of Coal Ash Proceedings

The site, a former coal-fired power plant in southern Illinois, generated coal combustion residuals (CCR) such as bottom ash and fly ash stored in surface impoundments. Adjacent to the Ash Pond, boron was detected in groundwater above the state standard of 2 mg/L. In late 2025, a groundwater extraction system was installed to control hydraulic conditions and prevent boron migration offsite until source control measures are completed. The system is expected to operate for up to 11 years. Three-dimensional groundwater modelling was used to support system design, helping to identify optimal well locations and flow rates for effective containment. Components, …


Narrative Power: Strengthening Coal Ash Communications In A Shifting Policy And Media Environment, Tamara Hinton May 2026

Narrative Power: Strengthening Coal Ash Communications In A Shifting Policy And Media Environment, Tamara Hinton

World of Coal Ash Proceedings

As coal ash management and beneficial use practices continue to advance and regulatory frameworks evolve, the industry still faces a persistent challenge: sharing its story clearly, credibly, and proactively to audiences beyond engineers and regulators. Public perception, media narratives, and stakeholder understanding increasingly influence policy decisions, project timelines, and market opportunities. This session focuses on how strategic communications can serve as a critical tool to support responsible coal ash management and beneficial use. This presentation explores how utilities and industry partners can move from reactive communications to a more deliberate, strategic approach that strengthens trust, mitigates risk, and reinforces the …


Benefits Of Geophysical Imaging For Coal Combustion Residuals Management Unit Delineation, Gabriel Herbert May 2026

Benefits Of Geophysical Imaging For Coal Combustion Residuals Management Unit Delineation, Gabriel Herbert

World of Coal Ash Proceedings

Gabriel J. Hebert1, Gregory B. Byer1, Margaret Gentile1 1Arcadis U.S., Inc., 2839 Paces Ferry Road SE, Suite 1000, Atlanta, GA 30339 KEYWORDS: geophysical imaging, delineation, CCRMU ABSTRACT Under the 2024 Legacy CCR Rule detailed in 40 CFR Part 257, Section 75, all electric utility companies with a known legacy coal combustion residuals (CCR) surface impoundment are required to conduct a facility evaluation to identify the location, dimensions, and volumes of CCR placed and remaining on site and to assess structural stability. At a minimum, the presence or absence of CCR management units (CCRMUs) must be documented through a desktop records …


Extracting Rees From Refuse Pile Coal, Howard Mcclintic May 2026

Extracting Rees From Refuse Pile Coal, Howard Mcclintic

World of Coal Ash Proceedings

Concurrent Technologies Corporation (CTC) has a patented high temperature electric arc furnace (EAF) technology that reaches 4000-degree centigrade temperature(s). Such high temperatures are sufficient to extract each of the seventeen rare earth elements (REEs) from coal fly ash to ultimately manufacture diverse magnets. Neodymium iron boron magnets (NdFeB) are the strongest magnets produced, heretofore almost exclusively by the Chinese. For national security reasons, CTC has become part of the domestic supply chain, as an alternate to China. Scaling is the next hurdle, since our demonstration unit is operational. Nationwide, coal is decreasingly used as a fuel for generating electricity. However, …


Providing Perspective On Arsenic Risks In The Human Health Risk Evaluation Of Coal Combustion Products (Ccps), Ari Lewis May 2026

Providing Perspective On Arsenic Risks In The Human Health Risk Evaluation Of Coal Combustion Products (Ccps), Ari Lewis

World of Coal Ash Proceedings

Arsenic has been a key risk factor in the evaluations for the 2015 Coal Combustion Residuals (CCR) Rule and the recent “Legacy Rule”, which addresses areas of historical CCP placement not covered by the 2015 rule. These risk assessments concluded that cancer risks from arsenic in various waste management scenarios exceeded the U.S. Environmental Protection Agency's (USEPA) target of 1 in 100,000 excess lifetime cancer cases, forming part of the basis for national CCP regulations. However, background exposure to naturally occurring arsenic in food, water, and soil also exceeds permissible levels, complicating risk conclusions. The USEPA's recent revision of arsenic …


Impacts Of Updating Background Groundwater Statistics For Ccr Compliance, May Raad, Molly Reeves May 2026

Impacts Of Updating Background Groundwater Statistics For Ccr Compliance, May Raad, Molly Reeves

World of Coal Ash Proceedings

In 2017, many power utilities adopted statistical methods to comply with the EPA’s Coal Combustion Residuals (CCR) Rule under the Hazardous and Solid Waste Management System. By 2017–2018, most owners completed initial statistical evaluations for detection and assessment monitoring to meet CCR deadlines. Groundwater sampling and analysis requirements in Parts 257.95, 257.98, and 257.102 are critical for compliance, yet implementation is complex. Subsections 257.93(f) and (g) lack clarity on which statistical tests to apply or how to address distributions and outliers. Additionally, the Rule does not specify when or how to update background threshold values (BTVs), though EPA’s Unified Guidance …


Lessons Learned From Managing Ash Pond Closure Waters, Danny Stephens, Tom Geeza, Phil Benson, Ashwin Ranna May 2026

Lessons Learned From Managing Ash Pond Closure Waters, Danny Stephens, Tom Geeza, Phil Benson, Ashwin Ranna

World of Coal Ash Proceedings

The water management issues created by ash pond closure are complex and can create technology selection and operational management challenges. Ash dewatering activities produce highly variable effluents, depending on ash composition, aging, and dewatering and stormwater management techniques. Effluent limitations can also be highly variable, depending upon the size of the receiving body and the anticipated composition of the effluent stream. The user often faces competing risks: installing an unnecessarily complex and expensive treatment plant, being limited on closure activities by limitations in water treatment capabilities, or both. This paper presents several lessons learned from assessing ash closure water management …


Transportation Logistics Panel, John Ward, Andrew Vollmer, Tracy Zea, Marci Jenks May 2026

Transportation Logistics Panel, John Ward, Andrew Vollmer, Tracy Zea, Marci Jenks

World of Coal Ash Proceedings

As the industry shifts from freshly generated ash to harvested materials and advanced utilization, logistics is becoming one of the primary drivers of project success or failure. This moderated panel will explore how sourcing, transportation, and storage realities are changing — and what project teams most often underestimate when working with harvested coal ash. Panelists will discuss what breaks, what becomes more complex, and how logistics considerations are reshaping planning and development.


The Importance Of Evaluating Drinking Water Exposure Pathway For Assessing Risks From Ccr Sites, Ari Lewis, Ishita Shrivastava May 2026

The Importance Of Evaluating Drinking Water Exposure Pathway For Assessing Risks From Ccr Sites, Ari Lewis, Ishita Shrivastava

World of Coal Ash Proceedings

Potential release of constituents present in coal combustion residuals (CCR) from CCR sites can pose risks to downgradient receptors via multiple exposure pathways. For residential receptors, these pathways include ingestion of impacted groundwater (when used as drinking water), other household uses (e.g., cooking, gardening), dermal contact during activities such as showering with impacted water or swimming in affected waterbodies, and ingestion of fish from affected waterbodies. Among these, the ingestion of groundwater used as drinking water is often the primary pathway driving potential risks (as identified in the risk assessment conducted by the United States Environmental Protection Agency in 2014). …


Demystifying Large Language Models: How Ai Is Transforming Data, Compliance, And Decision-Making In Coal Ash And Environmental Management, Scott Pfeiffer May 2026

Demystifying Large Language Models: How Ai Is Transforming Data, Compliance, And Decision-Making In Coal Ash And Environmental Management, Scott Pfeiffer

World of Coal Ash Proceedings

The environmental and coal combustion residuals (CCR) industries generate vast amounts of information—from groundwater monitoring reports and RCRA documentation to closure plans and analytical data. Managing, interpreting, and communicating this information is a growing challenge for utilities, regulators, and consultants alike. Large Language Models (LLMs), such as OpenAI’s GPT architecture, represent a breakthrough in how organizations can interact with their technical data. These models use deep neural networks trained on billions of words to understand, summarize, and generate language with human-like accuracy. When securely adapted for enterprise use, LLMs can automate routine reporting, extract data from technical documents, generate regulatory …


Expert Perspectives On The U.S. Coal Combustion Products Market – Now, Then, And The Future, Mark Rokoff, David Cox, Walter Lemaire, John Ward May 2026

Expert Perspectives On The U.S. Coal Combustion Products Market – Now, Then, And The Future, Mark Rokoff, David Cox, Walter Lemaire, John Ward

World of Coal Ash Proceedings

This panel discussion will explore the continued evolution of the U.S. coal combustion products market, with a focus on the impacts of dynamic regulatory and market forces. Invited expert panelists will share perspectives on developments over the past several years (building on discussions from WOCA 2022 and WOCA 2024), current conditions, and expected future trends—particularly those likely to shape the market between 2026 and 2030. The discussion will address the interrelated markets for engineering, construction, and beneficiation of ash from both operating and inactive plants. Panelists will offer perspectives relevant to the full coal ash industry, from owner/operator organizations to …


Utility-Scale Battery Energy Storage Systems - Field Pilot Unit Experience, Analysis, And Review Of Technological Advancements, Kwabena A. Kyeremeh, Shaun E. Lavin, Grant M. Fischer, Dan M. Ionel, Aron Patrick May 2026

Utility-Scale Battery Energy Storage Systems - Field Pilot Unit Experience, Analysis, And Review Of Technological Advancements, Kwabena A. Kyeremeh, Shaun E. Lavin, Grant M. Fischer, Dan M. Ionel, Aron Patrick

Electrical and Computer Engineering Graduate Research

Utility-scale Battery Energy Storage Systems (BESS) are becoming increasingly important in modern power systems, providing services ranging from backup support to load balancing and peak shaving. The long-term operational performance and reliability of these systems with expanding deployment remain insufficiently documented. This paper provides an operational assessment of a 1MW/2MWh utility-scale BESS alongside a systematic review of technology developments across major subsystems. Operational metrics including round-trip efficiency (RTE), outage characteristics, and degradation patterns are examined to identify performance trends and the underlying causes of outages. In addition, testing and operational principles aligned with utility practice and standards are presented to …


Building Resilience When Disaster Strikes, Anna G. Kalema, Felipe González-Seguel, Louisa A. Summers, Esther E. Dupont-Versteegden, Ashley A. Montgomery-Yates, Kirby P. Mayer May 2026

Building Resilience When Disaster Strikes, Anna G. Kalema, Felipe González-Seguel, Louisa A. Summers, Esther E. Dupont-Versteegden, Ashley A. Montgomery-Yates, Kirby P. Mayer

Physiology Faculty Publications

No abstract provided.


Seed Dormancy Cycling, Jingshi Yang, Yan Luo, Jerry M. Baskin, Carol C. Baskin, Andreas Prinzing, Luping Liu, Chaohan Xu, Keliang Zhang May 2026

Seed Dormancy Cycling, Jingshi Yang, Yan Luo, Jerry M. Baskin, Carol C. Baskin, Andreas Prinzing, Luping Liu, Chaohan Xu, Keliang Zhang

Plant and Soil Sciences Faculty Publications

Timing of seed germination is critical for survival of annual plants in seasonal climates. We tested the hypothesis that seeds of the winter annual species Cardamine impatiens (Brassicaceae) “track” their thermal environment and synchronize germination with favorable growth conditions. We predicted that seeds buried in the field from maturity to autumn germinate best at autumn temperatures, while those buried from maturity to spring germinate best in early spring. We monitored seasonal changes in germinability by exhuming field-buried seeds monthly for 30 months and incubating them under laboratory conditions. The effects of temperature on the transition of dormancy status also were …


Student Perspectives On Grading In Higher Education Stem Courses, Christopher Sean Burns, Daniela D.S. Digiacomo, Jennifer Pusateri, Katherine Ritchie, Christine Wusylko Apr 2026

Student Perspectives On Grading In Higher Education Stem Courses, Christopher Sean Burns, Daniela D.S. Digiacomo, Jennifer Pusateri, Katherine Ritchie, Christine Wusylko

Information Science Faculty Publications

Purpose

Despite a growing awareness of instructional practices that support student learning and well-being, higher education classrooms tend to still be dominated by the use of rigid approaches to assessment and course design. This study aims to understand the experiences of students in courses that implement a universal design for learning (UDL) pedagogical approach and an ungrading assessment approach. Design/methodology/approach

Leveraging a qualitative methodological approach, authors interviewed 13 graduate students in two library and information science technology courses and 11 undergraduate students in a computer science course in discrete mathematics about their experiences with ungrading within the context of UDL-designed …


Rural Community Perspectives On Hurricane Helene In Western North Carolina, Jennifer A. Horney, Lilly Moreau, Search Wnc Apr 2026

Rural Community Perspectives On Hurricane Helene In Western North Carolina, Jennifer A. Horney, Lilly Moreau, Search Wnc

Journal of Appalachian Health

Introduction: After making landfall on the Florida Gulf Coast in September 2024, Hurricane Helene impacted Western North Carolina (WNC) with historic flooding, landslides, and hurricane-force winds. More than 100 deaths in the region were attributed to the storm’s direct impacts.

Purpose: The purpose of this study was to assess community perspectives of long-term recovery in Mitchell and Yancey Counties, two rural WNC counties severely impacted by Hurricane Helene.

Methods: A 14-question interview guide was developed based on prior disaster research and the community engagement work of Sustaining Essential and Rural Community Healthcare (SEARCH). Questions covered post-Helene experiences related to access …


Exploring Systemic Challenges In The Western North Carolina Dental Safety Net: A Qualitative Analysis, Blaire Mirmow, Bill Milner, Nadia Laniado Apr 2026

Exploring Systemic Challenges In The Western North Carolina Dental Safety Net: A Qualitative Analysis, Blaire Mirmow, Bill Milner, Nadia Laniado

Journal of Appalachian Health

Introduction: Despite statewide growth, rural communities in Western North Carolina (WNC) face persistent barriers to oral health care driven by chronic dental workforce shortages and systemic geographic disparities. Within this Appalachian region, the dental safety net serves as a vital yet strained support system, struggling with limited financial resources and a lack of provider participation that leaves many underserved populations without essential oral health services.

Purpose: This study aims to explore the experiences of individuals working within the WNC dental safety net to identify barriers and strategies required to strengthen the delivery of oral health care in high-need rural settings. …


The Effects Of Hurricane Helene On Mental Health And Physical Activity, Hunter Smathers, Robyn York, Jarrett Walbolt Apr 2026

The Effects Of Hurricane Helene On Mental Health And Physical Activity, Hunter Smathers, Robyn York, Jarrett Walbolt

Journal of Appalachian Health

Introduction: Hurricane Helene brought widespread damage to Southern Appalachia, disrupting utilities, health care, and recreation. While natural disasters are linked to declines in mental and physical health, few studies have examined their effects on distinct types of physical activity (PA).

Purpose: This study evaluated the effects of Hurricane Helene on perceived stress, depressive symptoms, post-traumatic stress disorder (PTSD) symptomology, and intentional (exercise for health benefits) and incidental (physical labor or transportation) PA. Evacuation status influence was also explored.

Methods: Twenty participants completed assessments four weeks before (BASE), immediately after (0POST), and four weeks after landfall (4POST). Measures included the Perceived …


Environmental Exposure And Respiratory Health In Industrial Gulf Coast Communities, Ayodeji Iyanda, Chiung Fang Chang, Jennifer Erdely, Genny Carrillo, Tianjun Lu, Christopher Jones, Hilton Kelley, Daikwon Han, Xiao Huang, Yongmei Lu Apr 2026

Environmental Exposure And Respiratory Health In Industrial Gulf Coast Communities, Ayodeji Iyanda, Chiung Fang Chang, Jennifer Erdely, Genny Carrillo, Tianjun Lu, Christopher Jones, Hilton Kelley, Daikwon Han, Xiao Huang, Yongmei Lu

Epidemiology and Environmental Health Faculty Publications

Background: Industrialized communities along the U.S. Gulf Coast face persistent respiratory health inequities that are shaped by cumulative environmental exposures and social vulnerability. This study examined how residential proximity to multiple pollution sources interacts with sociodemographic and behavioral factors to influence respiratory outcomes in two industrial cities in Southeast Texas. Methods: A cross-sectional mixed methods design integrated survey data from 2,965 adult residents with 13 qualitative interviews. Multivariable logistic regression models estimated associations between self-reported residential proximity to pollution sources and physician-diagnosed asthma, chronic obstructive pulmonary disease (COPD), and other lung diseases, and included interaction terms to assess effect modification …


Patients' Attitudes Towards Deprescribing And Associations With Patient-Related Factors Across Two Hospital Settings, Louise Westberg Strejby Christensen, Iman El Gamah, Amina Osman Ismail Barre, Daniela Claudia Moga, Anissa Aharaz, Olivia Bornæs, Rikke Lundsgaard Nielsen, Aino Leegaard Andersen, Esben Iversen, Kim Peder Dalhoff, Ove Andersen, Helle Gybel Juul-Larsen, Morten Baltzer Houlind Apr 2026

Patients' Attitudes Towards Deprescribing And Associations With Patient-Related Factors Across Two Hospital Settings, Louise Westberg Strejby Christensen, Iman El Gamah, Amina Osman Ismail Barre, Daniela Claudia Moga, Anissa Aharaz, Olivia Bornæs, Rikke Lundsgaard Nielsen, Aino Leegaard Andersen, Esben Iversen, Kim Peder Dalhoff, Ove Andersen, Helle Gybel Juul-Larsen, Morten Baltzer Houlind

Epidemiology and Environmental Health Faculty Publications

Medication deprescribing is a targeted strategy to reduce inappropriate polypharmacy. Patients in primary care settings have reported high willingness to discontinue medications, but this phenomenon is less well studied in hospital settings. In this explorative post hoc analysis of two previously described clinical trials, we assessed patients' attitudes towards deprescribing in two hospital-based cohorts: acutely admitted older medical patients (≥ 65 years) in the emergency department at Copenhagen University Hospital Hvidovre (October 2018–April 2021) and multimorbid patients (≥ 18 years) referred to an outpatient clinic at Copenhagen University Hospital Amager (March 2019–December 2019). Among 104 and 72 patients in each …


Multi-Jurisdictional Hazard Mitigation Plan For Landslides For The Kentucky River Area Development District, Kentucky, Hudson J. Koch, Matt M. Crawford, Jason M. Dortch Apr 2026

Multi-Jurisdictional Hazard Mitigation Plan For Landslides For The Kentucky River Area Development District, Kentucky, Hudson J. Koch, Matt M. Crawford, Jason M. Dortch

Contract Reports--KGS

Landslides are a widespread and complex geologic hazard that affects people and infrastructure. The Kentucky River Area Development District, Kentucky, sustains relatively high landslide activity that impacts several municipalities in eastern Kentucky. This hazard mitigation planning project outlines landslide hazard and risk assessments for the Kentucky River Area Development District, with information needed for each community in the region to develop mitigation strategies that will support infrastructure and development needs, land-use planning, situational awareness, and response and recovery actions for the communities.


Mapping The Polar Neuro-Interactome Of Garcinia Mangostana Against The Ad-Pd-Als Nexus, Rahni Hossain, Sirirat Surinkaew, Pradoldej Sompol, Nasmah K. Bastaki, Rifat Jafrin, Nazim Sekeroglu, Jitbanjong Tangpong Apr 2026

Mapping The Polar Neuro-Interactome Of Garcinia Mangostana Against The Ad-Pd-Als Nexus, Rahni Hossain, Sirirat Surinkaew, Pradoldej Sompol, Nasmah K. Bastaki, Rifat Jafrin, Nazim Sekeroglu, Jitbanjong Tangpong

Markey Cancer Center Faculty Publications

Background/Objectives: Neurodegenerative diseases like Alzheimer’s, Parkinson’s, and Amyotrophic lateral sclerosis (ALS) share common molecular pathways, including neuroinflammation and oxidative stress, which complicate the effectiveness of single-target treatments. Garcinia mangostana L. (mangosteen) has shown neuroprotective properties, but previous studies focused on lipophilic xanthones, which have poor bioavailability and uncertain blood–brain barrier permeability. Methods: In the current study, polar metabolites from G. mangostana peel aqueous extract (GMPE) were assessed for potential multi-target interactions via UHPLC-QTOF-MS-based metabolomics, systems pharmacology, and molecular docking analysis. Further, in silico ADMET screening and network-based analyses assessed for overlap between GMPE compounds and genes associated with neurodegeneration (AD, …


A Pathogenic Tau Mutation Drives Autophagy-Lysosome Dysfunction That Limits Tau Degradation In A Model Of Frontotemporal Dementia, Farzaneh S. Mirfakhar, Jacob A. Marsh, Chihiro Sato, Kylie J. Schache, Miguel A. Minaya, Roland E. Dolle, Stephen C. Pak, Gary A. Silverman, David H. Perlmutter, Shannon L. Macauley, Celeste M. Karch Mar 2026

A Pathogenic Tau Mutation Drives Autophagy-Lysosome Dysfunction That Limits Tau Degradation In A Model Of Frontotemporal Dementia, Farzaneh S. Mirfakhar, Jacob A. Marsh, Chihiro Sato, Kylie J. Schache, Miguel A. Minaya, Roland E. Dolle, Stephen C. Pak, Gary A. Silverman, David H. Perlmutter, Shannon L. Macauley, Celeste M. Karch

Physiology Faculty Publications

Tau accumulates in a group of neurodegenerative diseases known as tauopathies. A prevailing hypothesis has been that Tau degradation is impaired due to an age-related imbalance in the autophagy-lysosome pathway, but whether these defects are a cause or consequence of Tau accumulation remains unclear. Here we show that a disease-causing mutation in the MAPT gene, which encodes Tau, p.R406W, is sufficient to disrupt multiple steps of the autophagy-lysosome pathway in human neurons. Using Airyscan super-resolution imaging, we find that mutant Tau neurons accumulate Tau and phosphorylated Tau in dysfunctional lysosomes, exhibit reduced lysosome motility, impaired fusion of autophagosomes and lysosomes, …


The Supreme Court's Goldilocks: Why The Major Questions Doctrine Is The Ideal Compromise Between Two Unattractive Extremes, Bradley P. Simpson Mar 2026

The Supreme Court's Goldilocks: Why The Major Questions Doctrine Is The Ideal Compromise Between Two Unattractive Extremes, Bradley P. Simpson

Kentucky Law Journal

No abstract provided.


Exposing Car Dealerships' Final Hidden Sales Con: A Call For The Disclosure Of Interest Rate Markups When "Helping" Buyers With Indirect Financing, John C. Simms Mar 2026

Exposing Car Dealerships' Final Hidden Sales Con: A Call For The Disclosure Of Interest Rate Markups When "Helping" Buyers With Indirect Financing, John C. Simms

Kentucky Law Journal

No abstract provided.