Digital Commons Network^™

‘I Went To The One Game In Town’: Obstetric And Maternity Unit Closures, Dwindling Birth Choices, And Resilience In Rural Appalachia, Sia Beasley

Theses and Dissertations--Anthropology

Obstetric and maternity health services are being rapidly eliminated in the rural United States, making maternal care more difficult to access and causing negative birth outcomes. Service closures have a magnified impact in Appalachia due to histories of systemic regional and state policy practices which devalue the lives of people living rural areas, local economic marginalization, geographic barriers, and insufficient health infrastructures. This research investigates how women living in rural Appalachia navigate pregnancy and birth amidst constant care closures. The Sunflower Mountain Region is a seven-county area in rural Southern Appalachia. The region has experienced ongoing obstetric closures over the …

Milky Way Morphology Probed By 6d Astrometric Data From The Gaia Space Telescope, Joshua Taylor Harry

Theses and Dissertations--Physics and Astronomy

At varying height above and below the plane of the Milky Way, I have used astrometric methods to classify stars of different galactic components of the Milky Way - the thin disk, thick disk, and stellar halo. This work complements prior study of Milky Way sub-structure - notably involving number density and/or pairwise correlations - which demonstrate non-steady state effects in the galaxy, such as axial/north-south symmetry breaking or more complex phenomena like the Gaia snail. This has motivated my exploration of stellar population changes with height about the Milky Way mid-plane, and the study of symmetry in such changes …

Data Acquisition, Analysis And Simulations For The Fermilab Muon G−2 Experiment, Fang Han

Theses and Dissertations--Physics and Astronomy

The goal of the new Muon g-2 E989 experiment at Fermi National Accelerator Laboratory (FNAL) is a precise measurement of the muon anomalous magnetic moment, a_μ ≡ (g-2)/2. The previous BNL experiment measured the anomaly a_μ(BNL) with an uncertainty of 0.54 parts per million (ppm). The discrepancy between the current standard model calculation of the a_μ(SM) and the previous measurement a_μ(BNL) is over 3σ. The FNAL Muon g-2 experiment aims at increasing the precision to 140 parts per billion (ppb) to resolve the discrepancy between the theoretical …

Grasslands, Communicating The Benefits, D. Keeney

IGC Proceedings (1977-2023)

The multiple benefits of perennial agriculture , including forages and grasslands, for building soil quality, protection of natural resources, enhancement of biodiversity and wildlife, are well known to us, but little understood by the public. This is not a situation where “more education” would necessarily increase recognition. Rather, we must build in the public a desire for the enhancement of green space, clean water and air, and diverse landscapes that multiple purpose agriculture can bring. We seek such environments intuitively and now that much of the world’s people are “trapped” in urban settings of steel and concrete, this desire is …

Single-Cell Analysis Of Aneurysmal Aortic Tissue In Patients With Marfan Syndrome Reveals Dysfunctional Tgf-Β Signaling, Ashley Dawson, Yanming Li, Yang Li, Pingping Ren, Hernan G. Vasquez, Chen Zhang, Kimberly R. Rebello, Waleed Ageedi, Alon R. Azares, Aladdein Burchett Mattar, Mary Burchett Sheppard, Hong S. Lu, Joseph S. Coselli, Lisa A. Cassis, Alan Daugherty, Ying H. Shen, Scott A. Lemaire

Saha Cardiovascular Research Center Faculty Publications

The molecular and cellular processes leading to aortic aneurysm development in Marfan syndrome (MFS) remain poorly understood. In this study, we examined the changes of aortic cell populations and gene expression in MFS by performing single-cell RNA sequencing (scRNA seq) on ascending aortic aneurysm tissues from patients with MFS (n = 3) and age-matched non-aneurysmal control tissues from cardiac donors and recipients (n = 4). The expression of key molecules was confirmed by immunostaining. We detected diverse populations of smooth muscle cells (SMCs), fibroblasts, and endothelial cells (ECs) in the aortic wall. Aortic tissues from MFS showed alterations …

Numerical Investigation On The Effect Of Spectral Radiative Heat Transfer Within An Ablative Material, Raghava S. C. Davuluri, Rui Fu, Kaveh A. Tagavi, Alexandre Martin

Mechanical Engineering Faculty Publications

The spectral radiative heat flux could impact the material response. In order to evaluate it, a coupling scheme between KATS - MR and P1 approximation model of radiation transfer equation (RTE) is constructed and used. A Band model is developed that divides the spectral domain into small bands of unequal widths. Two verification studies are conducted: one by comparing the simulation computed by the Band model with pure conduction results and the other by comparing with similar models of RTE. The comparative results from the verification studies indicate that the Band model is computationally efficient and can be used to …

Back To The Future – Pastoral Land Use In A Forest Land – Sustainability Challenges For The 21St Century, J. Morgan Williams

IGC Proceedings (1977-2023)

To contribute meaningfully to a session entitled “Deforestation” with a proposed paper title of “Trees in Pastoral Zones; Landuse Standards in the 21^st Century” necessitates I carefully define the scope of my contribution. My paper will draw on my experiences as an ecologist working in the pastoral lands of New Zealand in roles that have led me to delve increasingly into what constitutes sustainability (of people, land and economy) for a tiny multicultural nation maturing amidst the remnants of a unique Gondwanaland ecosystem. As New Zealand’s Parliamentary Commissioner for the Environment (PCE) I now examine a very wide range …

Grassland Use And Plant Diversity In Grazed Ecosystems, V. A. Deregibus, E. J. Jacobo, O. E. Ansin

IGC Proceedings (1977-2023)

Earth biomes are being deconstructed, through unprecedented rates of species disappearance or invasion (McCann 2000). This, added to the threat of global environmental change and changes in values of a developed society, caused that biodiversity became a topic that has captured the attention of the public as well as the scientific community. Such concern on the importance of biodiversity is based in four basic reasons clearly described by West (1993): (i) morality, that aims for the protection of species; (ii) aesthetics, as people desire to see and appreciate the living parts of nature; (iii) economics and, (iv) the array …

Core Collection Approaches And Genetic Diversity In Flemingia Macrophylla, R. Schultze‐Kraft, M. Peters

IGC Proceedings (1977-2023)

Core collections are a useful means to optimise the management, including conservation, of forage germplasm collections. Such optimisation is warranted in view of increasingly limited research resources. As there are several potential options to create core collections, a project is presented in which three approaches are compared: (i) based on germplasm origin information; (ii) genetic diversity assessment by agronomic characterisation/evaluation; and (iii) DNA markers. As example-species for the project, the tropical legume shrub Flemingia macrophylla is selected because of its particular multiple-use potential in smallholder production systems. An important diversity descriptor is the content of tannins influencing feed and litter …

Efficacy Of An Enhanced Implementation Strategy To Increase Parent Engagement With A Health Promotion Program In Childcare, Courtney T. Luecking, Cody D. Neshteruk, Stephanie Mazzucca, Dianne S. Ward

Dietetics and Human Nutrition Faculty Publications

Previous efforts to involve parents in implementation of childcare-based health promotion interventions have yielded limited success, suggesting a need for different implementation strategies. This study evaluated the efficacy of an enhanced implementation strategy to increase parent engagement with Healthy Me, Healthy We. This quasi-experimental study included childcare centers from the second of two waves of a cluster-randomized trial. The standard approach (giving parents intervention materials, prompting participation at home, inviting participation with classroom events) was delivered in 2016–2017 (29 centers, 116 providers, and 199 parents). The enhanced approach (standard plus seeking feedback, identifying and addressing barriers to parent participation) …

Reported Barriers To Hepatitis C Treatment Among Pregnant And Early-Parenting Mothers Undergoing Substance Use Disorder Treatment In One U.S. State, Ayooluwatomiwa Deborah Adekunle, Kathi L. Harp, Zaynab G. Al-Abdali, Agatha S. Critchfield, Sheila Barnhart, Kathleen T. Winter

Health Management and Policy Faculty Publications

Nationwide, the prevalence of the hepatitis C virus (HCV) has risen in recent years. At least 90% of infected persons must be treated to achieve global elimination targets. The current study aimed to explore barriers to, and facilitators of, direct-acting antiviral (DAA) HCV treatment uptake amongst pregnant and early-parenting women undergoing comprehensive substance use treatment. Twenty participants with documented HCV antibody positivity were recruited from two substance use treatment centers in central Kentucky. Semi-structured interviews were conducted to explore knowledge about HCV, previous experiences, and intentions to seek care. Themes were extracted using an inductive analytical approach. Most participants were …

Late-Life Exercise Mitigates Skeletal Muscle Epigenetic Aging, Kevin A. Murach, Andrea L. Dimet-Wiley, Yuan Wen, Camille R. Brightwell, Christine M. Latham, Cory M. Dungan, Christopher S. Fry, Stanley J. Watowich

Center for Muscle Biology Faculty Publications

There are functional benefits to exercise in muscle, even when performed late in life, but the contributions of epigenetic factors to late-life exercise adaptation are poorly defined. Using reduced representation bisulfite sequencing (RRBS), ribosomal DNA (rDNA) and mitochondrial-specific examination of methylation, targeted high-resolution methylation analysis, and DNAge™ epigenetic aging clock analysis with a translatable model of voluntary murine endurance/resistance exercise training (progressive weighted wheel running, PoWeR), we provide evidence that exercise may mitigate epigenetic aging in skeletal muscle. Late-life PoWeR from 22–24 months of age modestly but significantly attenuates an age-associated shift toward promoter hypermethylation. The epigenetic age of muscle …

The Effects Of Boric Acid Sugar Bait On Wolbachia Trans-Infected Male Aedes Albopictus (Zap Males®) In Laboratory Conditions, Vindhya S. Aryaprema, Whitney A. Qualls, Karen L. Dobson, Stephen L. Dobson, Rui-De Xue

Entomology Faculty Publications

The field release of Wolbachia trans-infected male mosquitoes, as well as the use of toxic sugar baits, is a novel and promising candidate technique for integrated mosquito management programs. However, the methods of action of the two techniques may not be complementary, because the Wolbachia method releases mosquitoes into the environment expecting a wild population reduction in subsequent generations while the toxic baits are intended to reduce the wild population by killing mosquitoes. This laboratory study was conducted to evaluate the effectiveness of boric acid toxic sugar baits on Wolbachia trans-infected male Aedes albopictus, relative to wild-type Ae. albopictus …

Perceived Exercise Habits Of Individuals With Parkinson’S Disease Living In The Community, Jordana Lockwich, Kate Schwartzkopf-Phifer, Camille L. Skubik-Peplaski, Richard D. Andreatta, Patrick H. Kitzman

Communication Sciences and Disorders Faculty Publications

Context

Exercise has been shown to improve gait in individuals with Parkinson’s disease (PD). Stepping practice at higher intensity levels has been suggested as a beneficial treatment option to improve gait in the neurological population. Unfortunately, this mode is poorly understood and underutilized within the PD population. Information on what individuals with PD are doing for exercise would be beneficial to help tailor exercise programs to improve gait and provide exercise options in the community for intensity-based exercise.

Objective

To investigate the current exercise habits of individuals living with PD in the community aimed at improving walking and to understand …

A Step-By-Step Guide To Implementing A Multidisciplinary Endocarditis Team, Sami El-Dalati, Daniel Cronin, James Riddell, Michael Shea, Richard L. Weinberg, Emily Stoneman, Twisha Patel, Kirra Ressler, George Michael Deeb

Internal Medicine Faculty Publications

Over the last several years multiple studies, primarily from European centers have demonstrated the clinical and outcomes benefits of multidisciplinary endocarditis teams. Despite this literature, adoption of this approach to patient care has been slower in the United States. While there is literature outlining the optimal composition of an endocarditis team, there is little information to guide providers as they attempt to transform practice from a fragmented, disjointed process to an efficient, collaborative care model. In this review, the authors will outline the steps they took to create and implement a successful multidisciplinary endocarditis team at the University of Michigan. …

Exploring Topics And Genres In Storytime Books: A Text Mining Approach, Soohyung Joo, Erin E. Ingram, Maria Cahill

Information Science Faculty Publications

Objective – While storytime programs for preschool children are offered in nearly all public libraries in the United States, little is known about the books librarians use in these programs. This study employed text analysis to explore topics and genres of books recommended for public library storytime programs.

Methods – In the study, the researchers randomly selected 429 children books recommended for preschool storytime programs. Two corpuses of text were extracted from the titles, abstracts, and subject terms from bibliographic data. Multiple text mining methods were employed to investigate the content of the selected books, including term frequency, bi-gram analysis, …

Finland, A Package Deal: Disciplinary Climate In Science Classes, Science Dispositions And Science Literacy, Larry J. Grabau, Jari Levonen, Kalle Juuti

Plant and Soil Sciences Faculty Publications

Finland’s educational prowess, though tempered by recent international assessments, has remained intact. This report focused on lessons that could be learned regarding secondary-level science education from the Program for International Student Assessment (PISA) 2015, science-focused assessment. That PISA iteration included not only science literacy but also students’ science dispositions (epistemology, enjoyment, interest, and self-efficacy) and the schools’ science climate measures (disciplinary climate and teaching support). Due to the hierarchical nature of the PISA data, multilevel models were employed in this Finnish study, involving 5582 students from 167 schools. Science dispositions (as outcome measures) were differently associated with teaching support and …

Single-Rail Adiabatic Logic For Energy-Efficient And Cpa-Resistant Cryptographic Circuit In Low-Frequency Medical Devices, Amit Degada, Himanshu Thapliyal

Electrical and Computer Engineering Graduate Research

Designing energy-efficient and secure cryptographic circuits in low-frequency medical devices are challenging due to low-energy requirements. Also, the conventional CMOS logic-based cryptographic circuits solutions in medical devices can be vulnerable to side-channel attacks (e.g. correlation power analysis (CPA)). In this article, we explored single-rail Clocked CMOS Adiabatic Logic (CCAL) to design an energy-efficient and secure cryptographic circuit for low-frequency medical devices. The performance of the CCAL logic-based circuits was checked with a power clock generator (2N2P-PCG) integrated into the design for the frequency range of 50 kHz to 250 kHz. The CCAL logic gates show an average of approximately 48% …

Deletion Of Sa Β-Gal+ Cells Using Senolytics Improves Muscle Regeneration In Old Mice, Cory M. Dungan, Kevin A. Murach, Christopher J. Zdunek, Zuo Jian Tang, Georgia L. Vonlehmden, Camille R. Brightwell, Zachary Hettinger, Davis A. Englund, Zheng Liu, Christopher S. Fry, Antonio Filareto, Michael Franti, Charlotte A. Peterson

Physical Therapy Faculty Publications

Systemic deletion of senescent cells leads to robust improvements in cognitive, cardiovascular, and whole-body metabolism, but their role in tissue reparative processes is incompletely understood. We hypothesized that senolytic drugs would enhance regeneration in aged skeletal muscle. Young (3 months) and old (20 months) male C57Bl/6J mice were administered the senolytics dasatinib (5 mg/kg) and quercetin (50 mg/kg) or vehicle bi-weekly for 4 months. Tibialis anterior (TA) was then injected with 1.2% BaCl₂ or PBS 7- or 28 days prior to euthanization. Senescence-associated β-Galactosidase positive (SA β-Gal+) cell abundance was low in muscle from both young and old mice …

Defining Disparities In Cochlear Implantation Through The Social Determinants Of Health, Marissa Schuh, Matthew L. Bush

Otolaryngology--Head & Neck Surgery Faculty Publications

Hearing loss is a global public health problem with high prevalence and profound impacts on health. Cochlear implantation (CI) is a well-established evidence-based treatment for hearing loss; however, there are significant disparities in utilization, access, and clinical outcomes among different populations. While variations in CI outcomes are influenced by innate biological differences, a wide array of social, environmental, and economic factors significantly impact optimal outcomes. These differences in hearing health are rooted in inequities of health-related socioeconomic resources. To define disparities and advance equity in CI, there is a pressing need to understand and target these social factors that influence …

Evidence Of Myomir Regulation Of The Pentose Phosphate Pathway During Mechanical Load-Induced Hypertrophy, Taylor Valentino, Vandre C. Figueiredo, C. Brooks Mobley, John J. Mccarthy, Ivan J. Vechetti Jr.

Physiology Faculty Publications

Many of the molecular and cellular mechanisms discovered to regulate skeletal muscle hypertrophy were first identified using the rodent synergist ablation model. This model reveals the intrinsic capability and necessary pathways of skeletal muscle growth in response to mechanical overload (MOV). Reminiscent of the rapid cellular growth observed with cancer, we hypothesized that in response to MOV, skeletal muscle would undergo metabolic programming to sustain increased demands to support hypertrophy. To test this hypothesis, we analyzed the gene expression of specific metabolic pathways taken from transcriptomic microarray data of a MOV time course. We found an upregulation of genes involved …

The Role Of Forages In Sustainable Cropping Systems Of Southern Australia, William D. Bellotti

IGC Proceedings (1977-2023)

The historical context, recent trends, and possible future role of forages in cropping systems are reviewed. Three recent themes will be developed: 1) The successful exploitation of genetic diversity resulting in commercial development of new legume species as pasture cultivars with specific traits better suited to the needs of current farming systems. 2) Improved understanding of key soil processes under grazed pastures, particularly soil water and soil nitrogen, and how these processes impact on indicators of sustainability like deep drainage and nitrate leaching. 3) An emerging capacity for predicting the effect of pasture-crop sequences on soil processes, crop growth and …

Effect Of Application Of Farmyard Manure To Ley On Forage Yield And Quality Of Grass Silage, T. M. Pauly, L. Rodhe

IGC Proceedings (1977-2023)

A two-year field trial was performed on ley near Uppsala, Sweden, with the following treatments (3 plots/treatment): A, no manure or fertiliser; B, manure applied in Oct.; C, manure applied in Oct. followed by rolling plots in May; D, manure applied in May; E, mineral fertiliser only. Apart from cattle manure, plots allocated to treatments B, C and D received the same amount of mineral nutrients as treatment E. The objective of this experiment was to get an indication of how different times of manure application (before or after the growth period) affected forage yields and the quality of the …

Ensiling Of Different Legumes Compared To Grass, S. Slottner, C. Rammer

IGC Proceedings (1977-2023)

The objective of this study was to examine the ensiling characteristics of four different forage legumes: galega (Galega orientalis), lucerne (Medicago sativa), white clover (Trifolium repens) and red clover (Trifolium pratense), and compare these with perennial ryegrass (Lolium perenne), using different additives. The crops were mowed using a sickle bar mower and chopped using a precision chop harvester. The crops were ensiled either direct cut or wilted to 35-45% DM. Wilting took place on a barn drier. Forages were ensiled either untreated or with addition of formic acid, Promyr or …

Global Patterns Of Potential Future Plant Diversity Hidden In Soil Seed Banks, Xuejun Yang, Carol C. Baskin, Jerry M. Baskin, Robin J. Pakeman, Zhenying Huang, Ruiru Gao, Johannes H. C. Cornelissen

Biology Faculty Publications

Soil seed banks represent a critical but hidden stock for potential future plant diversity on Earth. Here we compiled and analyzed a global dataset consisting of 15,698 records of species diversity and density for soil seed banks in natural plant communities worldwide to quantify their environmental determinants and global patterns. Random forest models showed that absolute latitude was an important predictor for diversity of soil seed banks. Further, climate and soil were the major determinants of seed bank diversity, while net primary productivity and soil characteristics were the main predictors of seed bank density. Moreover, global mapping revealed clear spatial …

Siderophore-Mediated Zinc Acquisition Enhances Enterobacterial Colonization Of The Inflamed Gut, Judith Behnsen, Hui Zhi, Allegra T. Aron, Venkateswaran Subramanian, William Santus, Michael H. Lee, Romana R. Gerner, Daniel Petras, Janet Z. Liu, Keith D. Green, Sarah L. Price, Jose Camacho, Hannah Hillman, Joshua Tjokrosurjo, Nicola P. Montaldo, Evelyn M. Hoover, Sean Treacy-Abarca, Benjamin A. Gilston, Eric P. Skaar, Walter J. Chazin, Sylvie Garneau-Tsodikova, Matthew B Lawrenz, Robert D Perry, Sean-Paul Nuccio, Pieter C. Dorrestein, Manuela Raffatellu

Pharmacy Nuclear Magnetic Resonance Center Faculty Publications

Zinc is an essential cofactor for bacterial metabolism, and many Enterobacteriaceae express the zinc transporters ZnuABC and ZupT to acquire this metal in the host. However, the probiotic bacterium Escherichia coli Nissle 1917 (or “Nissle”) exhibits appreciable growth in zinc-limited media even when these transporters are deleted. Here, we show that Nissle utilizes the siderophore yersiniabactin as a zincophore, enabling Nissle to grow in zinc-limited media, to tolerate calprotectin-mediated zinc sequestration, and to thrive in the inflamed gut. We also show that yersiniabactin’s affinity for iron or zinc changes in a pH-dependent manner, with increased relative zinc binding as the …

Best Practices For Performance Measurement In Transportation Operations And Maintenance, Bryan Gibson, Rachel Catchings, Chris Van Dyke, Steve Waddle, Doug Kreis

Kentucky Transportation Center Research Report

Public agencies benefit from measuring their performance as it helps to focus employee and organizational activities. State departments of transportation have become more performance-oriented over the past two decades and routinely collect data on highway safety, infrastructure condition, system operations, project delivery, winter maintenance, transit, bicycle and pedestrian facilities, and customer service. While the Kentucky Transportation Cabinet (KYTC) use performance measures in a variety of areas, the agency wants to adopt new metrics related to mobility and the responsiveness of maintenance operations. This report documents performance measurement strategies used at state transportation agencies throughout the country and proposes new performance …

Exclusive Breastfeeding And Professionals From The Family Health Strategy, Marialda Moreira Christoffel, Ana Leticia Monteiro Gomes, Cássia Leoneuza Augusto Julio, Julia Florentino De Barros, Elisa Da Conceição Rodrigues, Fernanda Garcia Bezerra Góes, Ana Maria Linares

Nursing Faculty Publications

OBJECTIVES: to analyze the perception of health professionals about exclusive breastfeeding in Family Health Strategy units in the city of Macaé.

METHODS: qualitative study carried out in four units of the Family Health Strategy in the city of Macaé, Rio de Janeiro. Thirty health professionals were interviewed from March to May 2019. Textual contents were processed in the IRaMuTeQ^® software by the Descending Hierarchical Classification.

RESULTS: professionals use different strategies for actions to promote, protect and support breastfeeding in prenatal consultations, but social and cultural determinants are important issues that interfere in this process, the involvement of the family …

Exploring The Digital Humanities Research Agenda: A Text Mining Approach, Soohyung Joo, Jennifer Hootman, Marie Katsurai

Information Science Faculty Publications

Purpose

This study aims to explore knowledge structure and research trends in the domain of digital humanities (DH) in the recent decade. The study identified prevailing topics and then, analyzed trends of such topics over time in the DH field.

Design/methodology/approach

Research bibliographic data in the area of DH were collected from scholarly databases. Multiple text mining techniques were used to identify prevailing research topics and trends, such as keyword co-occurrences, bigram analysis, structural topic models and bi-term topic models.

Findings

Term-level analysis revealed that cultural heritage, geographic information, semantic web, linked data and digital media were among the most …

Landomycins As Glutathione-Depleting Agents And Natural Fluorescent Probes For Cellular Michael Adduct-Dependent Quinone Metabolism, Alessio Terenzi, Mery La Franca, Sushilla Van Schoonhoven, Rostyslav Panchuk, Álvaro Martínez, Petra Heffeter, Redding Gober, Christine Pirker, Petra Vician, Christian R. Kowol, Rostyslav Stoika, Luca Salassa, Jürgen Rohr, Walter Berger

Pharmaceutical Sciences Faculty Publications

Landomycins are angucyclines with promising antineoplastic activity produced by Streptomyces bacteria. The aglycone landomycinone is the distinctive core, while the oligosaccharide chain differs within derivatives. Herein, we report that landomycins spontaneously form Michael adducts with biothiols, including reduced cysteine and glutathione, both cell-free or intracellularly involving the benz[a]anthraquinone moiety of landomycinone. While landomycins generally do not display emissive properties, the respective Michael adducts exerted intense blue fluorescence in a glycosidic chain-dependent manner. This allowed label-free tracking of the short-lived nature of the mono-SH-adduct followed by oxygen-dependent evolution with addition of another SH-group. Accordingly, hypoxia distinctly stabilized the fluorescent mono-adduct. While …