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Differential Gene Expression Profiles Reflecting Macrophage Polarization In Aging And Periodontitis Gingival Tissues, Octavio A. Gonzalez, Michael John Novak, Sreenatha S. Kirakodu, Arnold J. Stromberg, R. Nagarajan, Chifu B. Huang, K. C. Chen, Luis Orraca, J. Martinez-Gonzalez, Jeffrey L. Ebersole Sep 2015

Differential Gene Expression Profiles Reflecting Macrophage Polarization In Aging And Periodontitis Gingival Tissues, Octavio A. Gonzalez, Michael John Novak, Sreenatha S. Kirakodu, Arnold J. Stromberg, R. Nagarajan, Chifu B. Huang, K. C. Chen, Luis Orraca, J. Martinez-Gonzalez, Jeffrey L. Ebersole

Center for Oral Health Research Faculty Publications

Recent evidence has determined a phenotypic and functional heterogeneity for macrophage populations. This plasticity of macrophage function has been related to specific properties of subsets (M1 and M2) of these cells in inflammation, adaptive immune responses and resolution of tissue destructive processes. This investigation hypothesized that targeted alterations in the distribution of macrophage phenotypes in aged individuals, and with periodontitis would be skewed towards M1 inflammatory macrophages in gingival tissues. The study used a non-human primate model to evaluate gene expression profiles as footprints of macrophage variation in healthy and periodontitis gingival tissues from animals 3-23 years of age and …

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Mechanistic Insights Into Glucan Phosphatase Activity Against Polyglucan Substrates, David A. Meekins, Madushi Raththagala, Kyle D. Auger, Benjamin D. Turner, Diana Santelia, Oliver Kötting, Matthew S. Gentry, Craig W. Vander Kooi Sep 2015

Mechanistic Insights Into Glucan Phosphatase Activity Against Polyglucan Substrates, David A. Meekins, Madushi Raththagala, Kyle D. Auger, Benjamin D. Turner, Diana Santelia, Oliver Kötting, Matthew S. Gentry, Craig W. Vander Kooi

Molecular and Cellular Biochemistry Faculty Publications

Glucan phosphatases are central to the regulation of starch and glycogen metabolism. Plants contain two known glucan phosphatases, Starch EXcess4 (SEX4) and Like Sex Four2 (LSF2), which dephosphorylate starch. Starch is water-insoluble and reversible phosphorylation solubilizes its outer surface allowing processive degradation. Vertebrates contain a single known glucan phosphatase, laforin, that dephosphorylates glycogen. In the absence of laforin, water-soluble glycogen becomes insoluble, leading to the neurodegenerative disorder Lafora Disease. Because of their essential role in starch and glycogen metabolism glucan phosphatases are of significant interest, yet a comparative analysis of their activities against diverse glucan substrates has not been established. …

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We’Ll Show You Ours If You Show Us Yours! Favorite Technologies To Support Information Literacy, Beth Kraemer, Beth Fuchs Sep 2015

We’Ll Show You Ours If You Show Us Yours! Favorite Technologies To Support Information Literacy, Beth Kraemer, Beth Fuchs

Library Presentations

A recent user survey revealed that our students want more online tools to help them find and use library resources successfully. The challenge is finding and developing instruction-related technologies that are not only well-suited for local needs but also engaging and useful for students. We’ll show some of our recent developments, and then, it’s your turn! Come ready to contribute your ideas (or get a head start here: http://bit.ly/Beth2015), and leave with new online tools to explore.

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Methods For Increasing Renewable Oil Productions, David Hildebrand, Runzhi Li, Tomoko Hatanaka Sep 2015

Methods For Increasing Renewable Oil Productions, David Hildebrand, Runzhi Li, Tomoko Hatanaka

Plant and Soil Sciences Faculty Patents

Methods of increasing renewable oil production are provided and include transforming a plant cell with an isolated nucleic acid encoding a Vernonia galamensis diacylglycerol acyltransferase (V gDGAT) polypeptide, where the expression of the V gDGAT polypeptide increases an amount of renewable oil in the plant. Transgenic plant cells comprising an isolated nucleic acid encoding a Vernonia galamensis diacylglycerol acyl transferase 1 (V gDGATl) polypeptide are further provided.

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Stilbene Analogs And Methods Of Treating Cancer, David Watt, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang Sep 2015

Stilbene Analogs And Methods Of Treating Cancer, David Watt, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang

Pharmaceutical Sciences Faculty Patents

Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.

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Mirnas Regulated Overexpression Of Ryanodine Receptor Is Involved In Chlorantraniliprole Resistance In Plutella Xylostella (L.), Xiuxia Li, Lei Guo, Xuguo Zhou, Xiwu Gao, Pei Liang Sep 2015

Mirnas Regulated Overexpression Of Ryanodine Receptor Is Involved In Chlorantraniliprole Resistance In Plutella Xylostella (L.), Xiuxia Li, Lei Guo, Xuguo Zhou, Xiwu Gao, Pei Liang

Entomology Faculty Publications

The amino acid mutations in ryanodine receptor (RyR) and elevated activity of detoxification enzymes have been associated with the diamide insecticide resistance in the diamondback moth, Plutella xylostella (L.). The up-regulation of P. xylostella RyR mRNA (PxRyR) expression has also been reported in field populations of different graphical origin. However, whether the up-regulation of PxRyR is involved in diamide resistance remains unknown. In this paper, 2.28- to 4.14-fold higher expression of PxRyR was detected in five field collected resistant populations, compared to that in a susceptible population. The expression of PxRyR was up-regulated 5.0- and 7.2-fold, respectively, after …

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Disruption Of Daily Rhythms By High-Fat Diet Is Reversible, Katrina L. Branecky, Kevin D. Niswender, Julie S. Pendergast Sep 2015

Disruption Of Daily Rhythms By High-Fat Diet Is Reversible, Katrina L. Branecky, Kevin D. Niswender, Julie S. Pendergast

Biology Faculty Publications

In mammals a network of circadian clocks coordinates behavior and physiology with 24-h environmental cycles. Consumption of high-fat diet disrupts this temporal coordination by advancing the phase of the liver molecular clock and altering daily rhythms of eating behavior and locomotor activity. In this study we sought to determine whether these effects of high-fat diet on circadian rhythms were reversible. We chronically fed mice high-fat diet and then returned them to low-fat chow diet. We found that the phase of the liver PERIOD2::LUCIFERASE rhythm was advanced (by 4h) and the daily rhythms of eating behavior and locomotor activity were altered …

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Beckman Scholar 2005-06, Nicolas Badre Sep 2015

Beckman Scholar 2005-06, Nicolas Badre

Kaleidoscope

No abstract provided.

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Beckman Scholars Program, Uk Office Of Undergraduate Research Sep 2015

Beckman Scholars Program, Uk Office Of Undergraduate Research

Kaleidoscope

No abstract provided.

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Art, Attention, And Consciousness: An Experiment In Experiential Painting, Ben Drewry, Johannes Kohler Sep 2015

Art, Attention, And Consciousness: An Experiment In Experiential Painting, Ben Drewry, Johannes Kohler

Kaleidoscope

A “transformation of perception” is investigated by looking both at the interrelationship among art, attention, and consciousness and by looking into their common origin. The role attention plays in consciousness is considered. A new model of consciousness is summarized that claims that attention is the primary factor in creating consciousness, and posits a prereflective self prior to all perceptual experience. This model is compared to states of pure consciousness described by Eastern sages, and the role attention plays in achieving those states is examined. Our experiment in experiential painting is described, and we then attempt to tie together the three …

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The Study Of Plga Drug Delivery Systems: Implications For Management Of Crohn’S Disease, Christin Pramudiati Sep 2015

The Study Of Plga Drug Delivery Systems: Implications For Management Of Crohn’S Disease, Christin Pramudiati

Kaleidoscope

The purpose of this research is to develop biodegradable drug delivery systems. One of the delivery systems that we have developed is a suture-like structure for the treatment of Crohn’s disease that utilizes a biodegradable polymer, poly(DL-lactideco-glycolide) acid (PLGA). Crohn’s disease is an inflammatory bowel condition. Aside from the gut involvement, perianal complications develop in the form of enterocutaneous fistulas. Medical management of Crohn’s disease consists of various drugs with immunosuppressive properties. Complicated disease manifestation requires surgical interventions in the form of bowel resection or fistula drainage with Setons. Setons are suture-like devices that help to drain associated abscesses and …

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Differential Expression Of Mrna Encoding Cytokines And Chemokines In The Reproductive Tract After Infection Of Mice With Chlamydia Trachomatis, Katheryn L. Cerny, Maranda Van Fleet, Anatoly Slepenkin, Ellena M. Peterson, Phillip J. Bridges Sep 2015

Differential Expression Of Mrna Encoding Cytokines And Chemokines In The Reproductive Tract After Infection Of Mice With Chlamydia Trachomatis, Katheryn L. Cerny, Maranda Van Fleet, Anatoly Slepenkin, Ellena M. Peterson, Phillip J. Bridges

Animal and Food Sciences Faculty Publications

Infection with Chlamydia trachomatis targets epithelial cells within the genital tract which respond by secreting chemokines and cytokines. Persistent inflammation can lead to fibrosis, tubal infertility and/or ectopic pregnancy; many infections are asymptomatic. Most studies have investigated the inflammatory response in the initial stages of infection, less is known about the later stages of infection, especially with a low, potentially asymptomatic, bacterial load. Our objective was to determine the inflammatory mediators involved in clearance of low-grade infection and the potential involvement in chronic inflammation. Six to eight week old C3H/HeJ mice were pretreated with 2.5 mg medroxyprogesterone acetate on day …

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Novel Approaches Reveal That Toxoplasma Gondii Bradyzoites Within Tissue Cysts Are Dynamic And Replicating Entities In Vivo, Elizabeth Watts, Yihua Zhao, Animesh Dhara, Becca Eller, Abhijit R. Patwardhan, Anthony P. Sinai Sep 2015

Novel Approaches Reveal That Toxoplasma Gondii Bradyzoites Within Tissue Cysts Are Dynamic And Replicating Entities In Vivo, Elizabeth Watts, Yihua Zhao, Animesh Dhara, Becca Eller, Abhijit R. Patwardhan, Anthony P. Sinai

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Despite their critical role in chronic toxoplasmosis, the biology of Toxoplasma gondii bradyzoites is poorly understood. In an attempt to address this gap, we optimized approaches to purify tissue cysts and analyzed the replicative potential of bradyzoites within these cysts. In order to quantify individual bradyzoites within tissue cysts, we have developed imaging software, BradyCount 1.0, that allows the rapid establishment of bradyzoite burdens within imaged optical sections of purified tissue cysts. While in general larger tissue cysts contain more bradyzoites, their relative "occupancy" was typically lower than that of smaller cysts, resulting in a lower packing density. The packing …

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Oswald Research And Creativity Program, Uk Office Of Undergraduate Research Sep 2015

Oswald Research And Creativity Program, Uk Office Of Undergraduate Research

Kaleidoscope

No abstract provided.

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Uk Undergraduate Research Program, Uk Office Of Undergraduate Research Sep 2015

Uk Undergraduate Research Program, Uk Office Of Undergraduate Research

Kaleidoscope

No abstract provided.

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Summer Research And Creativity Grants, Uk Office Of Undergraduate Research Sep 2015

Summer Research And Creativity Grants, Uk Office Of Undergraduate Research

Kaleidoscope

No abstract provided.

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Beckman Scholar 2006-07, Kathryn Schweri Sep 2015

Beckman Scholar 2006-07, Kathryn Schweri

Kaleidoscope

No abstract provided.

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“Sometimes I Wish The Sun Would Just Explode:” Squidbillies, The Animated Hillbilly, And The Cultural Myth Of Appalachia, Kayla Rae Whitaker Sep 2015

“Sometimes I Wish The Sun Would Just Explode:” Squidbillies, The Animated Hillbilly, And The Cultural Myth Of Appalachia, Kayla Rae Whitaker

Kaleidoscope

No abstract provided.

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Prehistoric Drawings In Mammoth Cave, Logan Kistler Sep 2015

Prehistoric Drawings In Mammoth Cave, Logan Kistler

Kaleidoscope

During a recent Earthwatch Institute survey of archaeological remains in Mammoth Cave, a project was begun to find and record prehistoric images on the cave walls. I chose to analyze petroglyphs and pictographs on three panels in Main Cave. This article offers a hypothesis for the circumstances surrounding the rock art’s production: the geometric and anthropomorphic figures in Mammoth Cave are representative of a series of visual percepts experienced cross-culturally and caused by various conditions — including sensory deprivation, fatigue, and psychoactive drug use — acting on the ocular anatomy and nervous system. That is, the glyphs might be visual …

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Nietzsche Contra Wright: On Becoming What You Are, Jordan Rodgers Sep 2015

Nietzsche Contra Wright: On Becoming What You Are, Jordan Rodgers

Kaleidoscope

Robert Wright’s recent book on evolutionary psychology, The Moral Animal, is concerned largely with the ethical implications of recent evolutionary science, and espouses a form of utilitarianism as the ethical theory that should naturally follow evolutionary insights into human psychology. This paper challenges that notion, with constant reference to the work of the philosopher Friedrich Nietzsche, on the basis that such an ethical theory places far too little emphasis on the individual as such, and is tantamount to a form of nihilism. This paper also argues that, while seeking for the happiness of other people is a good thing, our …

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Complete Issue Of Volume 6 Sep 2015

Complete Issue Of Volume 6

Kaleidoscope

No abstract provided.

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Front Matter Sep 2015

Front Matter

Kaleidoscope

No abstract provided.

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From The Editor's Viewpoint, Robert S. Tannenbaum Sep 2015

From The Editor's Viewpoint, Robert S. Tannenbaum

Kaleidoscope

No abstract provided.

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Autophagy Is Induced Upon Platelet Activation And Is Essential For Hemostasis And Thrombosis, Madhu M. Ouseph, Yunjie Huang, Meenakshi Banerjee, Smita Joshi, Laura Macdonald, Yu Zhong, Huijuan Liu, Xianting Li, Binggang Xiang, Guoying Zhang, Masaaki Komatsu, Zhenyu Yue, Zhenyu Li, Brian Storrie, Sidney W. Whiteheart, Qing Jun Wang Sep 2015

Autophagy Is Induced Upon Platelet Activation And Is Essential For Hemostasis And Thrombosis, Madhu M. Ouseph, Yunjie Huang, Meenakshi Banerjee, Smita Joshi, Laura Macdonald, Yu Zhong, Huijuan Liu, Xianting Li, Binggang Xiang, Guoying Zhang, Masaaki Komatsu, Zhenyu Yue, Zhenyu Li, Brian Storrie, Sidney W. Whiteheart, Qing Jun Wang

Molecular and Cellular Biochemistry Faculty Publications

Autophagy is important for maintaining cellular homeostasis, and thus its deficiency is implicated in a broad spectrum of human diseases. Its role in platelet function has only recently been examined. Our biochemical and imaging studies demonstrate that the core autophagy machinery exists in platelets, and that autophagy is constitutively active in resting platelets. Moreover, autophagy is induced upon platelet activation, as indicated by agonist-induced loss of the autophagy marker LC3II. Additional experiments, using inhibitors of platelet activation, proteases, and lysosomal acidification, as well as platelets from knockout mouse strains, show that agonist-induced LC3II loss is a consequence of platelet signaling …

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Uk Undergraduate Research Program, Uk Office Of Undergraduate Research Sep 2015

Uk Undergraduate Research Program, Uk Office Of Undergraduate Research

Kaleidoscope

No abstract provided.

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Summer Research And Creativity Grants, Uk Office Of Undergraduate Research Sep 2015

Summer Research And Creativity Grants, Uk Office Of Undergraduate Research

Kaleidoscope

The abstracts in this section were submitted by students who received Research and Creativity Awards for the summer of 2008. Many are not final reports, because the projects were still in process when the submissions were due. Rather, they are progress reports. However, these abstracts provide a clear and wonderfully diverse picture of the broad range of scholarly activities being undertaken by undergraduates at the University of Kentucky.

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Behavioral And Morphological Parameters Of Neurons Predict The Inhibitory Potential Of Cspg Motifs: A Novel Technique, Edward Matin Kobraei Sep 2015

Behavioral And Morphological Parameters Of Neurons Predict The Inhibitory Potential Of Cspg Motifs: A Novel Technique, Edward Matin Kobraei

Kaleidoscope

Our lab aims to systematically identify the structural elements of chondroitin sulfate proteoglycans (CSPGs) that inhibit regeneration following spinal cord injury (SCI). CSPGs are extracellular matrix molecules produced by astrocytes of glial scar tissue following SCI. Central to this project is the use of CSPGs referred to as “Designer PGs,” which contain engineered modifications in the GAG chains and/ or the protein core of the neural CSPG aggrecan. Using established bioassays in vitro, we qualitatively and quantitatively measure growth cone behaviors and morphology as they interact with Designer PG molecules. These measurements are then translated into a composite inhibitory quotient …

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The Opening Chapters Of: Only A Game, Andrew Crown-Weber Sep 2015

The Opening Chapters Of: Only A Game, Andrew Crown-Weber

Kaleidoscope

These are what may turn out to be the first chapters of a novel tentatively called “Only A Game,” which could possibly be finished some time in the future, maybe. At present this book-to-be deals with the life of a young man who is addicted to one of the few new drugs to be discovered this century: massively multiplayer online role-playing games. If you are unfamiliar with this digital scourge, have some time on your hands, and haven’t eaten recently, I recommend Googling the term for an eye-opening experience. I won’t spoil all the many surprises and twists and intrigues …

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“In A Competition Full Of Hamburgers, You’Re A Steak:” American Idol And The Role Of Reality Television In The Maintenance Of Our Egos, Kathryn L. Braun Sep 2015

“In A Competition Full Of Hamburgers, You’Re A Steak:” American Idol And The Role Of Reality Television In The Maintenance Of Our Egos, Kathryn L. Braun

Kaleidoscope

Over the past decade, reality shows have ascended to the top of the Nielsen rating charts and have assumed a dominance that is difficult to cast aside. One such reality show, American Idol has grown in popularity over its last six seasons. This chapter discusses one of the main arguments of a larger honors thesis that examines the underlying motives that keep American viewers watching. As a cultural commodity, American Idol can be viewed as a product of American values and holds a societal purpose for its viewers. Therefore, the arguments within this chapter propose that the great popularity enjoyed …

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Complete Issue Of Volume 7 Sep 2015

Complete Issue Of Volume 7

Kaleidoscope

No abstract provided.

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