Digital Commons Network^™

Father Of All Destruction: The Role Of The White Father In Contemporary Post-Apocalyptic Cinema, Felicia Cosey

Theses and Dissertations--English

Since September 11, 2001 a substantial number of English-language, post-apocalyptic films have been released. This renewed interest in the genre has prompted scholars to examine the circumstances within western society that make post-apocalyptic films appealing to audiences. The popularity of these films derives from a narrative structure that reinforces conservative notions of good and bad and moral absolutism. The post-9/11, post-apocalyptic film typically features a white male hero who, in one way or another, reestablishes the pre-apocalyptic social order through proclamations of mandatory and prohibitive laws that must be adhered to by the survivors. The hero of post-apocalyptic film does …

The Convergance Of Arcadia, John Duncan

Theses and Dissertations--English

The Convergence of Arcadia is a story about people losing things. Stretching from the Jim Crow South, the Korean War, New York City and central Kentucky circa 1980, this story follows a one armed man who has given up on life, a sheriff haunted by his past, a Korean War veteran with a terrible secret and a family broken from suicide. The Convergence of Arcadia follows three families as their fates are inextricably wove together in the tradition of Southern Gothic literature.

Patriarchal Trauma In Appalachian Literature, Michelle Justus

Theses and Dissertations--English

Patriarchal Trauma in Appalachian Literature examines the effects of subjugation on women as it is represented in three novels set in Appalachia. I define patriarchal trauma as an act causing mental anguish to a woman and perpetrated against her because she is a woman. I use the term to encompass violent, catastrophic harms but more particularly to pinpoint the traumatic effects of the quotidian, systemic deprivation of women’s autonomy. Reconsidering classic texts such as James Still’s River of Earth and Robert Morgan’s Gap Creek: The Story of a Marriage as narratives of women’s trauma establishes a lineage on the subject, …

Comanche Boys, Benjamin D. Honea

Theses and Dissertations--English

Comanche Boys is a novel that was written and revised during Benjamin Honea’s time at the University of Kentucky. The novel focuses on Brandon, who lives in rural southwest Oklahoma, and how the arrival of two people in his life, one old and one new, changes his future irrevocably. Taking place at the intersections of modern American and Native American life, the narrative explores history, culture, mythology, faith, despair, racism, poverty, vengeance, and justice. The struggles of the past and present, the lost and reclaimed, propel and pervade the lives of the characters.

Life Matter: Women Subjects And Women's Objects In Innovative American Poetry, Jenna L. Goldsmith

Theses and Dissertations--English

Gertrude Stein, Lyn Hejinian, and Juliana Spahr employ innovative poetic practices attuned to nature and environment in order to understand their personal lives and depict these understandings for readers. My dissertation investigates how these poets enact an inclusive posture toward environment that many innovative and experimental women poets of the twentieth and twenty-first centuries possess, but are rarely recognized for. To this end, my dissertation provides counterarguments to characterizations of innovative or experimental poetic practices as reclusive, language-centric, opaque, and/or disconnected from the material world. I offer readings of poems, prose pieces, film, and art, to illustrate how materially innovative …

“The Land Is Our Family And The Water Is Our Bloodline”: The Dispossession And Preservation Of Heirs’ Property In The Gullah-Geechee Communities Of Lowcountry South Carolina, Brian Grabbatin

Theses and Dissertations--Geography

Heirs’ property is land that is collectively inherited by family members when an ancestor dies without a will. The complexity and ambiguity of rights among family members makes these parcels legally vulnerable to dispossession. This form of land tenure is found across the United States, but is particularly prevalent in southern African American communities, where educational inequities and distrust of law led to a reliance on extralegal practices of inheritance. This dissertation investigates the dispossession and preservation of heirs’ property in the Gullah-Geechee communities of Lowcountry South Carolina.

This investigation of heirs’ property is rooted in the interdisciplinary literature on …

Northside, Jesse L. Houk

Theses and Dissertations--English

The Northside of Lexington, Kentucky is an area with its own culture, community and art. While living in this community I was able to learn, grow and develop alongside this newly renovated area. The people and their lives intersect in such a way that creates a tension at times. However, many social awareness advocates vie for the success of this neighborhood for many years to come. The objective of studying such an area as the Northside in Lexington is to focus on the similarites rather than the differences in culture, community and artistic endeavor. With a collection of essays and …

The Language Of Race In Revolutionary France And Saint-Domingue, 1789-1792, Jeffery L. Stanley

Theses and Dissertations--History

This project studies the historical development of racialist language during the French Revolution as politicians, free people of color, and colonial whites debated the political status of France’s free people of color population. It examines the negotiation of a racialist language that bolstered colonial racial hierarchies with an egalitarian language that sought to level the corporate structures of the Old Regime. I look especially at the ways that language served as a management device to articulate and legitimize new relationships of power in the political culture of the French Revolution. I connect developments in France to the colonies by showing …

The Normative Architecture Of Reality: Towards An Object-Oriented Ethics, Justin L. Harmon

Theses and Dissertations--Philosophy

The fact-value distinction has structured and still structures ongoing debates in metaethics, and all of the major positions in the field (expressivism, cognitivist realism, and moral error theory) subscribe to it. In contrast, I claim that the fact-value distinction is a contingent product of our intellectual history and a prime object for questioning. The most forceful reason for rejecting the distinction is that it presupposes a problematic understanding of the subject-object divide whereby one tends to view humans as the sole source of normativity in the world. My dissertation aims to disclose the background against which human ethical praxis is …

Anthropocentrism As Environmental Ethic, Kyle L. Burchett

Theses and Dissertations--Philosophy

Ever since the environment and nonhumanity became major ethical topics, human-centered worldviews have been blamed for all that is morally wrong about our dealings with nature. Those who consider themselves nonanthropocentrists typically assume that the West’s anthropocentric axiologies and ontologies underlie all of the environmental degradations associated with our species. On the other hand, a handful of environmental philosophers argue that anthropocentrism is perfectly acceptable as a foundation for environmental ethics. According to Bryan Norton’s convergence hypothesis, "If reasonably interpreted and translated into appropriate policies, a nonanthropocentric ethic will advocate the same [environmental] policies as a suitably broad and long-sighted …

Becoming What We Are: Virtue And Practical Wisdom As Natural Ends, Keith Buhler

Theses and Dissertations--Philosophy

This dissertation is about ethical naturalism. Philippa Foot and John McDowell both defend contemporary neo-Aristotelian ethics but each represents a rival expression of the same. They are united in the affirmation that virtue is ‘natural goodness’ for human beings. Nevertheless, they are divided in their rival conceptions of ‘nature.’ McDowell distinguishes second nature or the "space of reasons" from first nature or the “realm of law.” Foot rejects this division.

On Foot's naturalism, natural goodness is just as much a feature of first nature as health is, even though human practical reasoning is unique in the biological world. I defend …

Forget Not The Whip! Nietzsche, Perspectivism, And Feminism: A Non-Apologist Interpretation Of Nietzsche’S Polemical Axiology, Jennifer L. Hudgens

Theses and Dissertations--Philosophy

The nineteenth-century German philosopher Friedrich Nietzsche is notoriously a misogynist according to many feminists. In parallel, Nietzsche’s theory of value, perspectivism, is relativist according to many philosophers. However, I propose a counter-reading of both Nietzsche’s comments regarding women and his comments regarding perspective in which I interpret Nietzsche as neither misogynistic nor relativistic. I adopt a stance which is non-apologist, in that I do not merely wash my hands of Nietzsche’s apparently sexist remarks about women as Walter Kaufmann does, for example. Rather I demonstrate that Nietzsche is performing a polemical attack on a particular kind of naïve feminism which …

Perception, Opportunity, Empowerment, And Policy: Women's Influence In Kentucky Agriculture, Courtney Lacy Jenkins

Theses and Dissertations--Community & Leadership Development

The number of women farmers in the United States is increasing at a substantial rate. Women are fulfilling various roles on the farm and stepping into formal leadership positions in the agricultural community. This study surveys the perception of women reputational leaders in Kentucky agriculture among traditional agricultural leaders, the opportunities available to women in agriculture, the sources empowering women to serve in leadership capacities in agriculture, and how women reputational leaders influence agriculture and agricultural policy in Kentucky. The research revealed that the dynamic of Kentucky agriculture is shifting. Women have made significant strides in agriculture as farmers and …

Identifying The Core Elements Of Developing Student Leaders In A College Ambassador Program, Megan Tennison

Theses and Dissertations--Community & Leadership Development

Within the university system, student organizations have historically had multiple positive influences on the students who choose to participate in them. This study looked at a particular banner organization in the College of Agriculture, Food and Environment at the University of Kentucky. Using the Social Change Model of Leadership Development theory as a backbone, a survey was created to evaluate the impact UK CAFE Ambassador Program has on its participants, as well as to identify avenues for improvement. This is a program that seeks to represent the college through recruitment and to develop student leaders through soft skill building. After …

Expectancy-Value In The Enrollment Factor Of Agricultural Education Youth, Morgan Schafbuch

Theses and Dissertations--Community & Leadership Development

This quantitative study considers the motivating factors for enrollment in secondary agricultural education courses from students whose home background is not from a farm. This study utilizes expectancy-value theory, and looks at students (n=211) from different agricultural backgrounds and the impact on their ability beliefs, expectancies for success, and usefulness, importance, and interest for enrollment in agricultural education courses. The results indicate that students who have no affiliation to a farm have the highest ability beliefs and expectancies for success towards agricultural education in relation to students who are from traditional agricultural backgrounds.

Effectiveness Of Biochar Addition In Reducing Concentrations Of Selected Nutrients And Bacteria In Runoff, Rachel Williams

Theses and Dissertations--Biosystems and Agricultural Engineering

Land application and storage of horse manure and municipal sludge can increase nutrient and bacteria concentrations in runoff. Biochar increases soil nutrient retention when used as a soil amendment. The objectives of this study were to determine if biochar, when mixed with horse manure or sludge, affects runoff concentrations of total Kjehldahl nitrogen (TKN), ammonia-nitrogen (NH3-N), nitrate (NO3-N), total phosphorus (TP), dissolved phosphorus (DP), total suspended solids (TSS), chemical oxygen demand (COD), and fecal coliforms (FC). Horse manure and sludge were applied to 2.4 x 6.1 m fescue plots (six each), with three plots of each material amended with 5-8% …

Evaluation Of Flocculation, Sedimentation, And Filtration For Dewatering Of Algal Biomass, Nicholas A. Rhea

Theses and Dissertations--Biosystems and Agricultural Engineering

Algae can be used as a feedstock for agricultural fertilizers, livestock/poultry feeds, anaerobic digestion, and biofuel production. Regardless of the end product, water removal is necessary and difficult to do cost effectively. For each product the requirements for moisture content (or solids content) vary, such that a desirable water removal strategy would need to be adaptable to varying levels of water removal. Flocculation, with sedimentation and drying was evaluated as a possible strategy for algae dewatering. Anionic and nonionic flocculants are known to be ineffective at flocculating algal culture, which was confirmed for this case by electro-osmotic flow testing of …

Induction Of Cellulase In High Solids Cultivation Of Trichoderma Reesei For Enhanced Enzymatic Hydrolysis Of Lignocellulose, Danielle Empson

Theses and Dissertations--Biosystems and Agricultural Engineering

This project aimed investigated cellulase in-situ production for large-scale on-farm production of lignocellulosic biofuel. Cellulase activity and glucose released by T. reesei with corn stover and wheat bran as co-substrates for solid state cultivation (SSC) were examined. Co-cultivation has previously increased T. reesei cellulase, but corn stover and wheat bran have not been co-cultivated (Dhillon, Oberoi et al. 2011). This work compared cellulase activity and glucose concentration of corn stover co-cultivated with 0-40% wheat bran in high solids. Samples with at least 20% wheat bran exhibited increased cellulase activity. However, the average glucose concentration without wheat bran was 3.29 g/L …

Physico-Chemical, Rheological And Baking Properties Of Proso Millet, Manjot Singh

Theses and Dissertations--Biosystems and Agricultural Engineering

Due to climate change, water scarcity, increasing population and rising food prices, agriculture and food security has been affected worldwide. Cereal grains being a major part of world food supply also act as important energy source in human diet. In order to counter food insecurity, alternative grains are being explored, and millet being drought-resistant has the potential to serve as an alternative grain due to its comparable nutritional composition with other major cereals and its gluten free proteins. The evidence that gluten sensitivity is one of the increasing food intolerances is driving an increasing demand for gluten-free foods. However, gluten …

Cerebrovascular Risk Factors, Arteriolar Sclerosis, And Cognitive Decline In The Kentucky Appalachian “Stroke-Belt”, Omar M. Al-Janabi

Theses and Dissertations--Medical Sciences

The relationship between cerebrovascular disease (CVD) risk factors and cognitive impairment or dementia has been widely studied with significant variability in findings between groups. We hypothesized that chronic small vessel injury in the form of arteriolar sclerosis, measured quantitatively using MRI to measure total white matter hyperintensity (WMH) volumes, would identify specific association of CVD risk factors and patterns of cognitive decline, associated with mild cognitive impairment of the cerebrovascular type, that represent the core features of vascular cognitive impairment in our cohort.

A Cross-sectional analysis of clinical and quantitative MRI data on 114 subjects with normal cognitive function (n=52) …

Evaluating The Use Of Second LifeTm For Virtual Team-Based Learning In An Online Undergraduate Anatomy Course, Christena Gazave

Theses and Dissertations--Medical Sciences

Team-based learning (TBL) is one strategy for improving team-work and critical thinking skills. It has proven to be an engaging teaching pedagogy in face-to-face classes, however, to our knowledge, has never been implemented online in a 3-D virtual world. We implemented virtual TBLs in an online undergraduate anatomy course using Second Life^TM, and evaluated whether it engaged students. This study was conducted over 2 semesters with 39 total students. Surveys and content analysis of transcripts were used to evaluate student engagement. Our results indicate virtual TBLs were engaging for most students. The average engagement score was 7.8 out …

Looking To The Future Of Stroke Treatment: Combining Recanalization And Neuroprotection In Acute Ischemic Stroke, Michael E. Maniskas

Theses and Dissertations--Neuroscience

Stroke is the 5^th leading cause of death in the U.S. with 130,000 deaths and around 800,000 affected annually. Currently, there is a significant disconnect between basic stroke research and clinical stroke therapeutic needs. Few animal models of stroke target the large vessels that produce cortical deficits seen in the clinical setting. Also, current routes of drug administration, intraperitoneal and intravenous, do not mimic the clinical route of intra-arterial drug administration. To bridge this divide, we have retro-engineered a mouse model of stroke from the current standard of care for emergent large vessel occlusion (ELVO) stroke, endovascular thrombectomy, to …

Novel Targets For Mitochondrial Dysfunction Following Traumatic Brain Injury, Heather M. Yonutas

Theses and Dissertations--Neuroscience

Mitochondrial dysfunction is a phenomenon observed in models of Traumatic Brain Injury (TBI). Loss of mitochondrial bioenergetics can result in diminished cellular homeostasis leading to cellular dysfunction and possible cellular death. Consequently, the resultant tissue damage can manifest as functional deficits and/or disease states. Therapeutic strategies to target this mitochondrial dysfunction have been investigated for models TBI and have shown promising effects.

For this project, we tested the hypothesis that mitoNEET, a novel mitochondrial membrane protein, is a target for pioglitazone mediated neuroprotection. To test this, we used a severe Controlled Cortical Impact (CCI) injury model in mitoNEET null and …

Statistical Inference On Dynamical Systems, Hongyuan Wang

Theses and Dissertations--Statistics

The ordinary differential equation (ODE) is one representative and popular tool in modeling dynamical systems, which are widely implemented in physics, biology, economics, chemistry and biomedical sciences, etc. Because of the importance of dynamical systems in scientific studies, they are the main focuses of my dissertation.

The first chapter of the dissertation is introduction and literature review, which mainly focuses on numerical integration algorithms of ODEs that are difficult to solve analytically, as well as derivative-free optimization algorithms for the so-called inverse problem.

The second chapter is on the estimation method based on numerical solvers of differential equations. We start …

A Randomized Controlled Trial Of Anesthesia Guided By Bis Vs. Standard Care And Effects On Cognition, Zohn Centimole

Theses and Dissertations--Nursing

Postoperative cognitive dysfunction (POCD) occurs frequently in individuals undergoing major surgery with general anesthesia. POCD adversely affects morbidity and health-related quality of life. Derived electroencephalographic (EEG) monitoring is utilized to guide the anesthesia provider in titration of volatile anesthetics. POCD has been associated volatile anesthetic neurotoxicity. EEG monitors are known to reduce a patient’s total cumulative dose exposure to volatile anesthetics. There is currently little evidence to support utilization of EEG monitors as a guide to reduce the incidence of POCD.

The purpose of this dissertation was to develop and test a technique of general anesthesia, delivered by anesthesia providers …

The Effect Of Nicotine Co-Administration On Alcohol-Induced Reactive Hippocampal Cell Proliferation During Abstinence In An Adolescent Model Of An Alcohol Use Disorder, Megan Heath

Theses and Dissertations--Pharmacy

A significant consequence of alcohol use disorders (AUDs) is hippocampal neurodegeneration. The hippocampus is responsible for learning and memory, and neurodegeneration in this brain region has been shown to result in cognitive deficits. Interestingly, some alcoholics demonstrate improvements in hippocampus-dependent functions, potentially due the phenomenon termed adult neurogenesis. Adult neurogenesis, the process by which neural stem cells (NSCs) proliferate, differentiate into neurons, migrate into the granule cell layer, and survive, occurs in two brain regions; however, this study examines only neurogenesis occurring in the subgranular zone of the hippocampal dentate gyrus. Four-day binge ethanol exposure in an animal model causes …

In Vitro Activity Of Polymyxin B And Meropenem Alone And In Combination Against Carbapenem-Resistant Enterobacteriaceae, Brandon T. Kulengowski

Theses and Dissertations--Pharmacy

Background: Infections caused by carbapenem-resistant Enterobacteriaceae such as Escherichia coli and Klebsiella pneumoniae are among the most urgent threats of the infectious disease realm. The incidence of these infections has only been increasing over the years and due to very limited treatment options, mortality is estimated at about 50%.

Methods: To evaluate the in vitro activity of meropenem and polymyxin B against carbapenem-resistant Enterobacteriaceae, antimicrobial susceptibility testing and time-kill studies were performed on K. pneumoniae clinical isolates representing a wide range of meropenem resistance (MICs 4 – 128 mg/L).

Results: Regrowth was observed at clinically relevant concentrations of meropenem alone …

Development Of Cocaine Hydrolase For Therapeutic Treatment Of Cocaine Abuse, Xiabin Chen

Theses and Dissertations--Pharmacy

Cocaine abuse is a world-wide public health and social problem without a U.S. Food and Drug Administration (FDA)-approved medication. An ideal anti-cocaine medication would accelerate cocaine metabolism producing biologically inactive metabolites by administration of an efficient cocaine-specific exogenous enzyme. Recent studies in our lab have led to discovery of the desirable, highly efficient human cocaine hydrolases (hCocHs) that can efficiently detoxify and inactivate cocaine without affecting normal functions of central nervous system (CNS). Preclinical and clinical data have demonstrated that these hCocHs are safe for use in humans and effective for accelerating cocaine metabolism. However, the actual therapeutic use of …

Acute Kidney Injury In Patients Treated With Vancomycin And Piperacillin-Tazobactam: A Retrospective Cohort Analysis, Wilbur Cliff Rutter

Theses and Dissertations--Pharmacy

Empiric antimicrobial therapy often consists of the combination of Gram-positive coverage with vancomycin (VAN) and Gram-negative coverage, specifically an anti-pseudomonal beta-lactam, such as piperacillin-tazobactam (PTZ). Nephrotoxicity is commonly associated with VAN therapy; however, recent reports demonstrate increasing nephrotoxicity rates among patients treated with the combination of VAN and PTZ. This study evaluated the effect of the VAN/PTZ combination on acute kidney injury (AKI), as defined by the RIFLE criteria, compared to VAN and PTZ monotherapies.

Overall, 11,650 patients were analyzed, with 1,647 (14.1%) AKI cases occurring. AKI was significantly more frequent in the VAN/PTZ group (21%) compared to either monotherapy …

Rna Nanotechnology For Next Generation Targeted Drug Delivery, Fengmei Pi

Theses and Dissertations--Pharmacy

The emerging field of RNA nanotechnology is developing into a promising platform for therapeutically application. Utilizing the state-of-art RNA nanotechnology, RNA nanoparticles can be designed and constructed with controllable shape, size for both RNA therapeutics and chemical drug delivery. The high homogeneity in particle size and ease for RNA therapeutic module conjugation, made it feasible to explore versatile RNA nanoparticle designs for preclinical studies.

One vital module for therapeutic RNA nanoparticle design is RNA aptamer, which can enable the RNA nanoparticles find its specific target for targeted drug delivery. A system of screening divalent RNA aptamers for cancer cell targeting …