Digital Commons Network^™

Synthesis And Characterization Of Curcumin Polymer For Application In Radiation Induced Lung Damage, Mark C. Bailey

Theses and Dissertations--Chemical and Materials Engineering

Radiotherapy is used as a primary treatment for many cancers, including lung cancer. Although radiotherapy has proven to be an effective cancer treatment, its use is heavily limited due to the peripheral toxicity to healthy tissue. In this work, the antioxidant, curcumin, was tested as a radioprotectant to reduce radiation damage to healthy cells. Curcumin has been limited in use due to its poor bioavailability. In order to avoid problems associated with free curcumin delivery, curcumin poly(beta-amino ester) (CPBAE) was synthesized.

The first study investigated the in vitro radioprotection effect of curcumin in HUVEC dosed with gamma radiation. Cells treated …

Acoustic Emission Of Lactococcus Lactis Ssp. Lactis C2 Infected With Three Bacteriophages C2, Sk1 And Ml3, Luxi Meng

Theses and Dissertations--Animal and Food Sciences

The objective of this research was to monitor the Acoustic Emission (AE) produced by Lactococcus lactis ssp. lactis C2 infected with three bacteriophages (c2, sk1 and ml3 at 90 min) using an acoustic emission-monitoring device which was designed at University of Kentucky in Lexington KY. The acoustic emission data was collected and then analyzed. These Acoustic Emission (AE) data suggested that bacteriophage ml3, sk1 and c2 can easily be distinguished by the differences in Absolute Energy (ABE), Centroid Frequency (CF) and Peak Frequency (PF) signals. The AE data suggested that bacteriophage sk1 and c2 caused greater stress on the lactis …

Post Weaning Supplementation Of April-Born Polypay And White Dorper Lambs Grazing Alfalfa/Orchardgrass Pasture, Lauren N. Wood

Theses and Dissertations--Animal and Food Sciences

The effect of post-weaning supplementation of April-born Polypay and White Dorper lambs grazing alfalfa/orchardgrass pasture during two grazing seasons from June to September was studied. One hundred seventy Polypay and 133 White Dorper lambs were randomly allotted to supplemented (2% BW daily) and unsupplemented groups. It was discovered that Polypay lambs weighed more than White Dorpers at wearning, when the grazing season began, and at the end of the 80 (Year 1) and 85 (Year 2) grazing season (P < 0.01). Polypay lambs gained faster (P < 0.01) than White Dorpers. Supplemented lambs gained faster (P < 0.01) than unsupplemented and Polypays had a greater response to supplementation (P < 0.01) than White Dorpers. Polypays had higher (P < 0.01) fecal egg counts, an indicator of Haemonchus contortus infestation. Supplementation did not have any consistent effect on reducing Haemonchus contortus infestation. Differences in forage characteristics of Polypay and White Dorper lambs did appear. Differences in alfalfa and orchardgrass dry matter, neutral detergent fiber, acid detergent fiber, and crude protein availability were measured by subtracting enter from exit availabilities. The largest decrease of alfalfa components from exit to enter was found with unsupplemented Polypays. No consistent effect was found for orchardgrass components.

Effect Of Maternal Diet On Select Fecal Bacteria In Mares And Their Foals, Morgan Brewer Pyles

Theses and Dissertations--Animal and Food Sciences

The process of microbial colonization in the gastrointestinal tract of foals and the factors influencing this process are not well understood. The objectives were to determine the effect of starch source in pelleted concentrates in the maternal diet on select fecal bacterial groups in mares and their foals and to evaluate changes in these bacterial groups over time. Thoroughbred foals (n=19) were from dams fed one of two concentrates: an oat-based (OB) or corn and wheat middling-based (CWB) pelleted concentrate. Fecal samples were collected from mares at 324 d of gestation, pre-foaling, 1 d, 14 d, and 28 d after …

Characteristics Of United States Seafood Consumers, Suliman Almojel

Theses and Dissertations--Agricultural Economics

In this thesis, I conducted an analysis of the consumption patterns associated with demographic and socio-economic characteristics, using Tobit and double-hurdle models. Data were collected for 11,574 households from the US Bureau of Labor Statistics for the year of 2014. Specific determinants included household size, age, income, gender, education, race, region, marital status, and whether the household lived in a coastal state. The results reveal that seafood expenditures are sequential decisions. Asian racial groups, households headed by married couples, a large number of members in households, higher income households, and households residing in the Atlantic and Gulf Coasts were variables …

The Agent Across The Border: "Russia" And "Ukraine" As Actors In The News, 2013-2015, Abbey L. Thomas

Theses and Dissertations--Linguistics

This study examines how two media sources—one Russian and one Ukrainian—portray Russia and Ukraine before, during, and after the EuroMaidan crisis in Ukraine. Russian-language texts posted between January 2013 and December 2015 on the sites Ukranews.com (a Ukrainian news outlet) and TASS.ru (Russian) were organized in a corpus of over 20,000,000 words. This study analyzes the nouns “Россия” (“Russia”) and “Украина” (“Ukraine”) according to the verbal predicates that attach to either noun. The results demonstrate predictable variation in the agency of the two entities in response to cultural events and contexts.

The analysis of the corpus data operationalizes a combined …

The Influence Of Time On Food Intake Patterns: Age, Period, Cohort Differences, Karina L. Christopher

Theses and Dissertations--Gerontology

The impact of diet and exercise on overall health and chronic disease risk has been well examined. Multiple studies show that Americans eat more now than they did fifty years ago. What isn’t known is how much of an impact time has on food intake patterns of individuals in terms of different age groups, historic periods of structural influences, and birth cohorts.

In order to identify the impact of time on food intake this study examined time from multiple perspectives. The first aim of this study was to determine food intake patterns among age groups across five time periods using …

The Perception Of Creaky Voice: Does Speaker Gender Affect Our Judgments?, Kaitlyn E. Lee

Theses and Dissertations--Linguistics

This study focuses on the phonetics of creaky voice saliency and the perceptual sociolinguistic indexes that are evoked during creaky voice use. This study consists of two experiments: the first a listener judgment based Likert scale, the second an AXB study. The first experiment used modal and creaky voice statement-of-fact tokens to determine whether the speaker is or isn’t x characteristic (intelligent, feminine, educated, masculine, hesitant, and confident). This study found that both male and female speakers were found to be less intelligent, less educated, less feminine, more masculine, less confident, and more hesitant when using creaky voice phonation as …

Investigating Ichneumonidae: Insights Into Species Identification And Venom Composition, Victoria G. Pook

Theses and Dissertations--Entomology

Parasitoid wasps are hyperdiverse, with current estimates suggesting that they may account for up to 20% of all insect species. Though their ecological significance and their importance in integrated pest management cannot be denied, these taxa remain understudied and, due to their small size, are often overlooked. However, recent advances in molecular techniques are helping to reverse this trend by providing tools which scientists can use to better understand species limits and host interactions.

Parasitoid wasps are often morphologically cryptic and their accurate delimitation requires the analysis of DNA sequence data from fast-evolving genes in addition to morphological characters. The …

The Influence Of Cholesterol-Related Membrane Fluidity On The Shear Stress Control Of Neutrophil Adhesion And Its Implications In Hypercholesterolemia, Michael L. Akenhead

Theses and Dissertations--Biomedical Engineering

Hypercholesterolemia is a significant risk factor in the development of cardiovascular disease and is associated with chronic leukocyte adhesion in the microvasculature. While the underlying mechanisms behind this have yet to be determined, it may be possible that hypercholesterolemia impairs the fluid shear stress (FSS) inactivation of neutrophils through the rigidifying effect of cholesterol on membrane fluidity. FSS restricts surface expression of CD18 integrins through cathepsin B (ctsB) proteolysis, which minimizes neutrophil adhesivity. If hypercholesterolemia blocks FSS mechanotransduction, then the inhibition of CD18 cleavage may link pathologic blood cholesterol elevations with dysregulated neutrophil adhesion. We hypothesized that elevated cholesterol contributes …

Correlating Bulk Density (With Dockage) And Test Weight (Without Dockage) For Wheat Samples, Rumela Bhadra, Mark E. Casada, Josephine M. Boac, Aaron P. Turner, Sidney A. Thompson, Michael D. Montross, Ronaldo G. Maghirang, Samuel G. Mcneill

Biosystems and Agricultural Engineering Faculty Publications

In grain bins, the compaction of stored grain is caused by the overbearing pressure of the bulk material in the bin. To predict the amount of grain in the bin, compaction values must be determined based on the average bulk density (BD) of the stored material. However, BD is determined following the Federal Grain Inspection Service (FGIS) guidelines for measuring test weight (TW), which require that dockage be removed prior to measuring wheat TW. Thus, this creates a problem for predicting grain compaction and conducting inventory studies, because the average BD of the grain in a bin for these calculations …

A Review Of Non-Destructive Methods For Detection Of Insect Infestation In Fruits And Vegetables, Nader Ekramirad, Akinbode A. Adedeji, Reza Alimardani

Biosystems and Agricultural Engineering Faculty Publications

Insect damage in fruits and vegetables cause major production and economic losses in the agriculture and food industry worldwide. Monitoring of internal quality and detection of insect infestation in fruits and vegetables is critical for sustainable agriculture. Early detection of an infestation in fruits can facilitate the control of insects and the quarantine operations through proper post-harvest management strategies and can improve productivity. The present review recognizes the need for developing a rapid, cost-effective, and reliable insect infestation monitoring system that would lead to advancements in agriculture and food industry. In this paper, an overview of non-destructive detection insect damages …

Home Vegetable Gardening In Kentucky [2016], Richard Durham, Shubin Saha, John Strang, Mark A. Williams, Shawn Wright, Ricardo Bessin, Brad Lee, Emily Pfeufer

Agriculture and Natural Resources Publications

Every aspiring gardener should follow seven steps to have a successful gardening season:

1. Plan your garden on paper before you begin.
2. Select a good gardening site that is:
   a. in full sun for at least eight hours each day,
   b. relatively level,
   c. well‑drained,
   d. close to a water source,
   e. dries quickly from morning dew.
3. Prepare the soil properly, conduct a soil test, and add fertilizer and lime according to U.K. test result recommendations.
4. Plan only as large a garden as you can easily maintain. Beginning gardeners often overplant, and then they fail because they cannot keep up with …

The Effect Of Varying Bisphosphonate Treatment On Changes In Bone Microdamage In Osteoporotic Women, Stefanie L. Pagano

Theses and Dissertations--Biomedical Engineering

Bisphosphonates (BPs) are used for the treatment of osteoporosis. This study evaluated changes in bone microdamage with BP treatment duration. Fifty-one iliac crest biopsies were obtained from Caucasian women, ages 41 to 87 years, who were previously diagnosed and treated for osteoporosis with oral BPs for 1-16 years duration. Patients diagnosed with any disease, drug, or substance abuse that may affect bone metabolism were excluded.

Bone samples were sectioned, stained, and histologically examined using light and fluorescence microscopy. Bone area, number and length of microcracks were quantified. Following adjustment for age, BMD, BV/TV, trabecular thickness, and turnover, regression analysis revealed …

Analysis Of Scientific Investigations Related To Reclamation Of Surface Mining Control And Reclamation Act Permitted Coal Mines With Coal Combustion By-Products, Kimery C. Vories

Coal Combustion and Gasification Products Journal Archive

In the United states, the placement of coal combustion by-products (CCBs) (i.e., fly ash, bottom ash, boiler slag, flue gas desulfurization material, and fluidized bed combustion material) in coal mines has been an area of controversy. Federal and state governments, universities, the National Energy Technology Laboratory, and industrial research organizations have taken an active role in encouraging and promoting technological advances, research, and technology transfer related to the use of CCBs at coal mines. CCBs have been placed at Surface Mining Control and Reclamation Act of 1977 (SMCRA) permitted mines since 1977 to serve the following purposes: (1) a seal …

Kentucky Annual Economic Report 2016, Christopher R. Bollinger, William H. Hoyt, David Blackwell, Michael T. Childress

Kentucky Annual Economic Report

No abstract provided.

Agriculture, Drainage Districts, And The Clean Water Act: Does What Happens In Des Moines Stay In Des Moines?, Harrison Pittman, Rusty Rumley

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

The Dragon Looks North: The Arctic, China, And The Law Of The Sea Bring Prospects For New Opportunities And New Perils, Peter Rosene

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Table Of Contents For Volume 9, Issue 1, Kentucky Journal Of Equine, Agriculture, & Natural Resources Law

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Update On Antitrust And The Legal Issues Surrounding Cloning In The Equine World, Lewis T. Stevens

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Pitts V. Barr-Tonko Bills: An In-Depth Comparison Of Proposed Anti-Doping Legislation In Horse Racing, Peter J. Sacopulos

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Trademarking Animal Abuse: Should The Tennessee Walking Horse Breeders' And Exhibitors' Association ("Twhbea") Lose The Twhbea Trademark Portfolio Under The Lanham Act For Failure To Comply With The Horse Protection Act?, Esther L. Roberts

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Composting Swine Manure From High Rise Finishing Facilities, Edwin L. Ritchey, Kim Cook

Plant and Soil Sciences Research Report

Swine production has restructured considerably in recent years with increased production on fewer farms (Key et al., 2011). Most swine production facilities manage manure in liquid form either in deep pits underneath production facilities or in lagoons adjacent to the production facilities (Key et al., 2011). This management uses water to rinse manure from the facilities, which dilutes the nutrient concentration and value of the manure. The liquid forms are applied to land through irrigation systems or by liquid manure spreaders. Liquid manure management can have some operational constraints that composting eliminates (Bernal et al., 2009). The most common issue …

Soil Cores For Kentucky Science Education, Mark S. Coyne, Carol Hanley, Amber Harris

Plant and Soil Sciences Faculty Book Gallery

No abstract provided.

Kentucky’S Primary Care Workforce Shortages 2016 - 2025 And Recommendations For Increasing The Production Of Primary Care Physicians For Kentucky, Kevin A. Pearce, Carol Hustedde, Linda M. Asher, Sydney P. Thompson, Frances J. Feltner, Katherine Mckinney

Center of Excellence in Rural Health Workforce Reports

An excerpt from the executive summary:

Kentucky and the nation face severe shortages of primary care (PC) physicians. PC physicians are essential to cost-effective healthcare. Kentucky ranks 40^th among the United States in its PC physician workforce per 100,000 people, with 2,696 practicing PC physicians statewide.

The purposes of this white paper are to:

1. Present up-to-date data and information about the primary care workforce in Kentucky
2. Describe current trainee pipelines that supply new primary care physicians to Kentucky
3. Recommend strategies and tactics for improving the primary care physician workforce

A Summary Of The Kentucky River Watershed Watch 2016 Water Sampling Results, Kentucky Water Resources Research Institute

Kentucky River Watershed Watch

No abstract provided.

Uk Law Notes, 2016, University Of Kentucky College Of Law

Annual Magazines

No abstract provided.

Altered Cerebellar Circuitry Following Thoracic Spinal Cord Injury In Adult Rats, Nishant P. Visavadiya, Joe E. Springer

Physical Medicine and Rehabilitation Faculty Publications

Cerebellar function is critical for coordinating movement and motor learning. However, events occurring in the cerebellum following spinal cord injury (SCI) have not been investigated in detail. We provide evidence of SCI-induced cerebellar synaptic changes involving a loss of granule cell parallel fiber input to distal regions of the Purkinje cell dendritic tree. This is accompanied by an apparent increase in synaptic contacts to Purkinje cell proximal dendrites, presumably from climbing fibers originating in the inferior olive. We also observed an early stage injury-induced decrease in the levels of cerebellin-1, a synaptic organizing molecule that is critical for establishing and …

Why Did The Organic Chicken Cross The Road? To See The Proposed Livestock Welfare Rules In The National Organic Program, Kael Bowling

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Protecting Kentucky's Honey Bees: What's Killing The Buzz, Why It Matters, And What We Can Do To Help, Christine M. Ficker

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.