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Land Condition And Overgrazing: A Management Paradox For The Savannas Of Northern Australia, Andrew J. Ash, John G. Mcivor, Joel R. Brown
Land Condition And Overgrazing: A Management Paradox For The Savannas Of Northern Australia, Andrew J. Ash, John G. Mcivor, Joel R. Brown
IGC Proceedings (1977-2023)
The tropical savannas of northern Australia have been an important resource for the production of beef for over a century. Excessive stocking rates regimes have led, in some areas, to degradation of the soil and vegetation resource. A state-and-transition model is used to describe the decline in land condition with overgrazing. A grazing study has been established at 2 sites to determine the consequences of a change in land condition for animal production, and pasture production and quality are being related to land condition at additional small sites. Preliminary results indicate that as pasture condition declines, pasture production decreases but …
Case Studies And Causes Of Weed Invasion Of Sown Pastures On The Wet Tropical Coast Of Eastern Australia, H G. Bishop, T B. Hilder, G A. Lambert, E R. Anderson
Case Studies And Causes Of Weed Invasion Of Sown Pastures On The Wet Tropical Coast Of Eastern Australia, H G. Bishop, T B. Hilder, G A. Lambert, E R. Anderson
IGC Proceedings (1977-2023)
Viability of large and successful sown pasture development on the wet tropical coast of eastern Australia is threatened from invasion of these pastures by unpalatable grass and legume weeds. The main threats discussed are invasion by the unpalatable grass weeds Sporobolus diandrus (tussocky sporobolus) and Sporobolus pyramldalis (giant rat's tall grass) and the unpalatable, annual legume weed Senna obtusifolia (sicklepod). Specific cases of invasion and suggested causes for the problems are discussed. The major causes· suggested for pasture decline and invasion by less productive weedy species are: disease that can suddenly wipe out an otherwise …
Importance Of Legume Nitrogen Fixation In Sustainability Of Pasture In The Cerrados Of Brazil, G Cadisch, E F. Carvalho, A R. Suhet, L Vilela, W Soares, J M. Spain, S Urquiaga, K E. Giller, R M. Boddey
Importance Of Legume Nitrogen Fixation In Sustainability Of Pasture In The Cerrados Of Brazil, G Cadisch, E F. Carvalho, A R. Suhet, L Vilela, W Soares, J M. Spain, S Urquiaga, K E. Giller, R M. Boddey
IGC Proceedings (1977-2023)
A pure Andropogon gayanus sward was compared with a Stylosanthes spp.-A. gayanus mixed sward in order to assess the benefit of introducing N2-fixing legumes on the long-term sustainability of grazed pastures. There was no difference between the total dry matter and animal production of the 2 pastures, although the legumes fixed 67-117 kg/ha of N in 1991 with 80% of the legume N obtained from N2 fixation. Litter deposition was 20-35% greater in the mixed sward and the % N in this litter was also higher, leading to twice the amount of N mineralised in the 0-5 cm …
An Integrated Approach To Soil-Plat-Animal Interactions On Grazed Legume-Based Pastures On Tropical Acid Soils, M J. Fisher, C E. Lascano, R J. Thomas, M A. Ayarza, I M. Rao, G Rippstein, J.H M. Thornley
An Integrated Approach To Soil-Plat-Animal Interactions On Grazed Legume-Based Pastures On Tropical Acid Soils, M J. Fisher, C E. Lascano, R J. Thomas, M A. Ayarza, I M. Rao, G Rippstein, J.H M. Thornley
IGC Proceedings (1977-2023)
Legume-based pastures developed by the Tropical Pastures Program (TPP) of CIAT give spectacular increases in both stocking rates and animal live-weight gains on the savannas of Latin America, A team within the TPP is addressing the problems of their management for legume persistence and soil-plant-animal interactions, using as Its focus a grazing experiment on 2 oxisols of contrasting texture on the Colombian Llanos. The objective is to model the pastures to forecast the effect of management options on long-term persistence and nutrient cycling in grazed legume•grass associations in the Latin American savannas.
Evaluation Of Pastures For Sustained Beef Production In Subtropical New South Wales, P T. Mears, D L. Garden, R W. Dicker
Evaluation Of Pastures For Sustained Beef Production In Subtropical New South Wales, P T. Mears, D L. Garden, R W. Dicker
IGC Proceedings (1977-2023)
Limitations of low-quality grass pastures, soil fertility, mechanisms of legume persistence and the long-term sustainability of pastures for beef production were studied in a humid subtropical environment of New South Wales, Australia. Sustainability of pastures and animal growth responses in 3 experiments (varying from 4 to 10 years' duration) al 2 sites have been analysed and described. Steers or heifers were used lo assess the effects of introducing subtropical or temperate legumes, level of superphosphate and stocking rate on natural grass pastures, Principal factors which improved the level of beef production from pasture were (i) introducing persistent legumes (ii) level …
Complex Tissue Regeneration In Lophuromys Reveals A Phylogenetic Signal For Enhanced Regenerative Ability In Deomyine Rodents, Brennan Riddell, Molly Mcdonough, Adam Ferguson, John M. Kimani, Thomas R. Gawriluk, Chi Peng, Stephen G. Kiama, Vanessa O. Ezenwa, Ashley W. Seifert
Complex Tissue Regeneration In Lophuromys Reveals A Phylogenetic Signal For Enhanced Regenerative Ability In Deomyine Rodents, Brennan Riddell, Molly Mcdonough, Adam Ferguson, John M. Kimani, Thomas R. Gawriluk, Chi Peng, Stephen G. Kiama, Vanessa O. Ezenwa, Ashley W. Seifert
Biology Faculty Publications
Identifying why complex tissue regeneration is present or absent in specific vertebrate lineages has remained elusive. One also wonders whether the isolated examples where regeneration is observed represent cases of convergent evolution or are instead the product of phylogenetic inertia from a common ancestral program. Testing alternative hypotheses to identify genetic regulation, cell states, and tissue physiology that explain how regenerative healing emerges in some species requires sampling multiple species among which there is variation in regenerative ability across a phylogenetic framework. Here, we interrogate tissue healing across eleven rodents and show that brush-furred mice (Lophuromys zena) are capable of …
Land Use Change Consistently Reduces Α- But Not Β- And Γ-Diversity Of Bees., Toby P N Tsang, A A Amado De Santis, Gabriela Armas-Quiñonez, John S Ascher, Eva Samanta Ávila-Gómez, András Báldi, Kimberly M Ballare, Mario V Balzan, Weronika Banaszak-Cibicka, Svenja Bänsch, Yves Basset, Adam J Bates, Jessica M Baumann, Mariana Beal-Neves, Ashley Bennett, Antonio Diego M Bezerra, Betina Blochtein, Riccardo Bommarco, Berry Brosi, Laura A Burkle, Luísa G Carvalheiro, Ignacio Castellanos, Marcela Cely-Santos, Hamutahl Cohen, Drissa Coulibaly, Saul A Cunningham, Sarah Cusser, Isabelle Dajoz, Deborah A Delaney, Ek Del-Val, Monika Egerer, Markus P Eichhorn, Eunice Enríquez, Martin H Entling, Natalia Escobedo-Kenefic, Pedro Maria Abreu Ferreira, Gordon Fitch, Jessica R K Forrest, Valérie Fournier, Robert Fowler, Breno M Freitas, Hannah R Gaines-Day, Benoît Geslin, Jaboury Ghazoul, Paul Glaum, Jose L Gonzalez-Andujar, Adrian González-Chaves, Heather Grab, Claudio Gratton, Solène Guenat, Catalina Gutiérrez-Chacón, Mark A Hall, Mick E Hanley, Annika Hass, Ernest Ireneusz Hennig, Martin Hermy, Juliana Hipólito, Andrea Holzschuh, Sebastian Hopfenmüller, Keng-Lou James Hung, Kristoffer Hylander, Jordi Izquierdo, Mary A Jamieson, Birgit Jauker, Steve Javorek, Shalene Jha, Björn K Klatt, David Kleijn, Alexandra-Maria Klein, Anikó Kovács-Hostyánszki, Jochen Krauss, Michael Kuhlmann, Patricia Landaverde-González, Tanya Latty, Misha Leong, Susannah B Lerman, Yunhui Liu, Ana Carolina Pereira Machado, Anson Main, Rachel Mallinger, Yael Mandelik, Bruno Ferreira Marques, Kevin Matteson, Frédéric Mccune, Ling-Zeng Meng, Jean Paul Metzger, Paula María Montoya-Pfeiffer, Carolina Morales, Lora Morandin, Jane Morrison, Sonja Mudri-Stojnić, Pakorn Nalinrachatakan, Olivia Norfolk, Mark Otieno, Mia G Park, Stacy M Philpott, Gideon Pisanty, Montserrat Plascencia, Simon G Potts, Eileen F Power, Kit Prendergast, Robyn D Quistberg, Davi De Lacerda Ramos, André Rodrigo Rech, Victoria Reynolds, Miriam H Richards, Stuart P M Roberts, Malena Sabatino, Ulrika Samnegård, Hillary Sardiñas, Karina Sánchez-Echeverría, Fernanda Teixeira Saturni, Jeroen Scheper, Amber R Sciligo, C Sheena Sidhu, Brian J Spiesman, Tuanjit Sritongchuay, Ingolf Steffan-Dewenter, Katharina Stein, Alyssa B Stewart, Jane C Stout, Hisatomo Taki, Pornpimon Tangtorwongsakul, Caragh G Threlfall, Carla Faleiro Tinoco, Teja Tscharntke, Katherine J Turo, Chatura Vaidya, Rémy Vandame, Carlos H Vergara, Blandina F Viana, Eric Vides-Borrell, Natapot Warrit, Elisabeth Webb, Catrin Westphal, Jennifer B Wickens, Neal M Williams, Nicholas S G Williams, Caleb J Wilson, Panlong Wu, Elsa Youngsteadt, Yi Zou, Lauren C Ponisio, Timothy C Bonebrake
Land Use Change Consistently Reduces Α- But Not Β- And Γ-Diversity Of Bees., Toby P N Tsang, A A Amado De Santis, Gabriela Armas-Quiñonez, John S Ascher, Eva Samanta Ávila-Gómez, András Báldi, Kimberly M Ballare, Mario V Balzan, Weronika Banaszak-Cibicka, Svenja Bänsch, Yves Basset, Adam J Bates, Jessica M Baumann, Mariana Beal-Neves, Ashley Bennett, Antonio Diego M Bezerra, Betina Blochtein, Riccardo Bommarco, Berry Brosi, Laura A Burkle, Luísa G Carvalheiro, Ignacio Castellanos, Marcela Cely-Santos, Hamutahl Cohen, Drissa Coulibaly, Saul A Cunningham, Sarah Cusser, Isabelle Dajoz, Deborah A Delaney, Ek Del-Val, Monika Egerer, Markus P Eichhorn, Eunice Enríquez, Martin H Entling, Natalia Escobedo-Kenefic, Pedro Maria Abreu Ferreira, Gordon Fitch, Jessica R K Forrest, Valérie Fournier, Robert Fowler, Breno M Freitas, Hannah R Gaines-Day, Benoît Geslin, Jaboury Ghazoul, Paul Glaum, Jose L Gonzalez-Andujar, Adrian González-Chaves, Heather Grab, Claudio Gratton, Solène Guenat, Catalina Gutiérrez-Chacón, Mark A Hall, Mick E Hanley, Annika Hass, Ernest Ireneusz Hennig, Martin Hermy, Juliana Hipólito, Andrea Holzschuh, Sebastian Hopfenmüller, Keng-Lou James Hung, Kristoffer Hylander, Jordi Izquierdo, Mary A Jamieson, Birgit Jauker, Steve Javorek, Shalene Jha, Björn K Klatt, David Kleijn, Alexandra-Maria Klein, Anikó Kovács-Hostyánszki, Jochen Krauss, Michael Kuhlmann, Patricia Landaverde-González, Tanya Latty, Misha Leong, Susannah B Lerman, Yunhui Liu, Ana Carolina Pereira Machado, Anson Main, Rachel Mallinger, Yael Mandelik, Bruno Ferreira Marques, Kevin Matteson, Frédéric Mccune, Ling-Zeng Meng, Jean Paul Metzger, Paula María Montoya-Pfeiffer, Carolina Morales, Lora Morandin, Jane Morrison, Sonja Mudri-Stojnić, Pakorn Nalinrachatakan, Olivia Norfolk, Mark Otieno, Mia G Park, Stacy M Philpott, Gideon Pisanty, Montserrat Plascencia, Simon G Potts, Eileen F Power, Kit Prendergast, Robyn D Quistberg, Davi De Lacerda Ramos, André Rodrigo Rech, Victoria Reynolds, Miriam H Richards, Stuart P M Roberts, Malena Sabatino, Ulrika Samnegård, Hillary Sardiñas, Karina Sánchez-Echeverría, Fernanda Teixeira Saturni, Jeroen Scheper, Amber R Sciligo, C Sheena Sidhu, Brian J Spiesman, Tuanjit Sritongchuay, Ingolf Steffan-Dewenter, Katharina Stein, Alyssa B Stewart, Jane C Stout, Hisatomo Taki, Pornpimon Tangtorwongsakul, Caragh G Threlfall, Carla Faleiro Tinoco, Teja Tscharntke, Katherine J Turo, Chatura Vaidya, Rémy Vandame, Carlos H Vergara, Blandina F Viana, Eric Vides-Borrell, Natapot Warrit, Elisabeth Webb, Catrin Westphal, Jennifer B Wickens, Neal M Williams, Nicholas S G Williams, Caleb J Wilson, Panlong Wu, Elsa Youngsteadt, Yi Zou, Lauren C Ponisio, Timothy C Bonebrake
Entomology Faculty Publications
Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α-diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ-diversity), either due to reduced β-diversity amplifying diversity loss or increased β-diversity dampening diversity loss. Additionally, studies often focus on taxonomic diversity, while other important biodiversity components, including phylogenetic diversity, can exhibit differential responses. Here, we evaluated how agricultural and urban land use alters the taxonomic and phylogenetic α-, β-, and γ-diversity of an important pollinator taxon-bees. Using a multicontinental dataset of 3117 bee …
Puppy Dog Eyes: Begging For Treats And The Regulation Of Dog Breeding, Abigail Barford
Puppy Dog Eyes: Begging For Treats And The Regulation Of Dog Breeding, Abigail Barford
Kentucky Journal of Equine, Agriculture, & Natural Resources Law
In this note, Abigail Barford explores the lack of regulation over dog breeding in Kentucky, particularly the harms caused by puppy mills and backyard breeders. Barford explains that loopholes in the Animal Welfare Act and Kentucky’s absence of state-level protections contribute to dog overpopulation, inhumane conditions, environmental damage, and financial burdens on taxpayers. Barford argues for Kentucky to adopt strong breeding regulations modeled on Pennsylvania’s laws and its own equine breeding system. She proposes statewide legislation to license breeders, enforce humane standards of care, and regulate small-scale breeding to curb overpopulation and protect animal welfare.
Coffee Farmgate Price And Post-Harvest Processing In Honduras., Isaac Desouza
Coffee Farmgate Price And Post-Harvest Processing In Honduras., Isaac Desouza
Theses and Dissertations--Agricultural Economics
Volatile commodity markets and changing climate expose coffee farmers to price and production risk. Proponents recommend specialty coffee as a strategy to combat price risk, because its unique attributes differentiate it from commodity coffee. Extrinsic and intrinsic attributes define specialty coffee and affect prices at many levels of the supply chain. Despite much work on extrinsic attributes, little is known about how intrinsic attributes relate to farmgate price. Post-harvest processing is itself an intrinsic trait and driver of coffee quality. In 2024 we surveyed 261 coffee farmers from La Paz, Honduras, to uncover relationships between capital, post-harvest processing, and farmgate …
The Rhythm Of Renewables: Minute-By-Minute Insights From Kentucky, David S. Beyerle, Noah M. Stewart, Shaun E. Lavin, Chad C. Alkire, Heather Nikolic, Samuel Kelty, Ezekiel A. Boggs, Declan Boyle, Lawrence E. Holloway, Aron Patrick
The Rhythm Of Renewables: Minute-By-Minute Insights From Kentucky, David S. Beyerle, Noah M. Stewart, Shaun E. Lavin, Chad C. Alkire, Heather Nikolic, Samuel Kelty, Ezekiel A. Boggs, Declan Boyle, Lawrence E. Holloway, Aron Patrick
Electrical and Computer Engineering Faculty Publications
Kentucky’s renewable energy landscape beats with a distinct rhythm shaped by ever-changing variations in sunlight, wind, rainfall, and the ever-modernizing grid that connects them. This paper analyzes minute-by-minute performance data from seven renewable and storage assets owned and operated by the PPL Corporation in Kentucky, including hydroelectric, solar, wind, and lithium-ion battery systems. Using a full year of synchronized, high-resolution data from multiple sites in the Commonwealth, the study examines daily and seasonal capacity factor trends, explores correlations among generation types, and evaluates their alignment with utility load profiles. Our analysis found 279 hours—about 3.2% of the year—with zero renewable …
Behavioral And Physiological Responses Of Heifers With No Prior Exposure And Those Adapted To Grazing Endophyte-Infected Tall Fescue, Tyler A. Purvis
Behavioral And Physiological Responses Of Heifers With No Prior Exposure And Those Adapted To Grazing Endophyte-Infected Tall Fescue, Tyler A. Purvis
Theses and Dissertations--Animal and Food Sciences
Data from year one of a three-year experiment was used to determine behavioral and physiological responses of heifers adapted to grazing endophyte-infected fescue (E+TF) compared to heifers naïve to grazing E+TF. In May, yearling beef heifers from KY (n=15) and MT (n=30) were stratified by body weight, hair coat score, and disposition into nine pastures and assigned to one of three treatments: KY grazing E+ (KY-E+), MT grazing E+ (MT-E+), or MT grazing endophyte-free tall fescue (E-TF) (MT-E-). Prior to grazing, two heifers per pasture were selected to be outfitted with a RumiWatch® halter (Itin+Hoch GmbH, Liestal, Switzerland) for monitoring …
Nf-Κb-Mediated Oxidative Stress Drives Cigarette Smoke-Induced Emt In Human Bronchial Cells, Sarah M. Alqithami
Nf-Κb-Mediated Oxidative Stress Drives Cigarette Smoke-Induced Emt In Human Bronchial Cells, Sarah M. Alqithami
Theses and Dissertations--Toxicology and Cancer Biology
Cigarette smoke contains over 7,000 chemicals, many being carcinogens and proinflammatory agents contributing to chronic respiratory diseases like COPD and lung cancer. This study investigated responses of human bronchial epithelial cells (HBECs) to cigarette smoke condensate (CSC), focusing on oxidative stress and NF-κB signaling. Three HBEC lines were exposed to non-cytotoxic CSC doses for 48 hours, inducing morphological changes consistent with epithelial-to-mesenchymal transition (EMT). RNA sequencing revealed transcriptomic shifts in all cell lines, particularly affecting genes related to oxidative stress, inflammation, hypoxia, and metabolism. Enrichment analyses confirmed activation of NRF2 antioxidant, NF-κB and IL-17 inflammatory, and hypoxiainducible factor pathways, indicating …
Elucidating The Adverse Effects Of Chronic Pfos Exposure On Gastrointestinal Pathology And Colorectal Cancer, Jerika Durham
Elucidating The Adverse Effects Of Chronic Pfos Exposure On Gastrointestinal Pathology And Colorectal Cancer, Jerika Durham
Theses and Dissertations--Toxicology and Cancer Biology
Commonly referred to as "forever chemicals," per- and polyfluoroalkyl substances (PFAS) have been linked to a number of detrimental health effects, including an elevated risk of cancer. One "long-chain" subtype of PFAS, perfluorooctanesulfonic acid (PFOS), has a long elimination half-life and a significant propensity for bioaccumulation. Because PFOS is commonly found in drinking water, the gastrointestinal system absorbs it at a high rate. Recent studies demonstrate that PFAS exposures promote intestinal inflammation and gut barrier dysfunction. However, how a long-term PFOS exposure affects colorectal cancer (CRC) progression is not known. Therefore, the purpose of this research is to understand how …
Investigating Plk1 In Pulmonary Fibrosis, Tempany Arbogast
Investigating Plk1 In Pulmonary Fibrosis, Tempany Arbogast
Theses and Dissertations--Toxicology and Cancer Biology
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease, with a median survival of only 2–3 years following diagnosis. In the United States, the disease contributes to more than 40,000 deaths annually, underscoring its severe clinical burden. Alveolar type II (AT2) lung epithelial cells serve as progenitors that maintain alveolar integrity by replenishing epithelial populations and producing surfactants, while fibroblasts and myofibroblasts regulate the extracellular matrix and structural support. In pulmonary fibrosis (PF) injury to AT2 cells promotes cytokine and growth factor release, driving inflammation, fibroblast proliferation, myofibroblast accumulation, and excessive extracellular matrix deposition. Aberrant AT2 cell …
Forage News [2025-01], University Of Kentucky
Forage News [2025-02], University Of Kentucky
Forage News [2025-12], University Of Kentucky
Forage News [2025-11], University Of Kentucky
Forage News [2025-10], University Of Kentucky
Forage News [2025-09], University Of Kentucky
Forage News [2025-06], University Of Kentucky
Forage News [2025-05], University Of Kentucky
Forage News [2025-04], University Of Kentucky
Current Practices In Training Paraeducators: A Literature Review, Rebekah Pearson
Current Practices In Training Paraeducators: A Literature Review, Rebekah Pearson
Theses and Dissertations--Early Childhood, Special Education, and Counselor Education
I conducted a brief literature review to examine current practices for training paraeducators in school settings. I reviewed literature published after 2010 using an online database. Using an author-made inclusion criterion, 13 articles were considered for review. Findings suggest that behavior skills training (BST), brief performance feedback, didactic training, and a strategy instruction framework are currently being used to train paraeducators. These trainings have yielded positive results in increasing desired paraeducator behaviors. I conclude by discussing the limitations and directions for future research.
Influence Of Naturalistic Language Intervention On Child Communication And Engagement, Olivia R. Abate
Influence Of Naturalistic Language Intervention On Child Communication And Engagement, Olivia R. Abate
Theses and Dissertations--Early Childhood, Special Education, and Counselor Education
The purpose of this study is to parallel naturalistic instructional contexts that often occur during caregiver-child interactions (e.g., one-to-one arrangement during play) to learn more about how children respond when prompting is introduced compared to responsive interaction strategies alone or with environmental arrangement strategies. This exploratory study was designed to evaluate the potential differential effects within an ATD, comparing RI alone, RI + EA, and RI + MP on joint engagement, communication acts, and interfering behaviors. This study is ongoing and lacks results for communication acts. Preliminary results supported and contradicted aspects of the hypothesis: joint engagement would occur at …
Portable Multi-Parametric Microscopy For Noninvasive Metabolic And Vascular Imaging Of Orthotopic Tongue Cancer Models In Vivo, Pranto Soumik Saha, Jing Yan, Caigang Zhu
Portable Multi-Parametric Microscopy For Noninvasive Metabolic And Vascular Imaging Of Orthotopic Tongue Cancer Models In Vivo, Pranto Soumik Saha, Jing Yan, Caigang Zhu
Markey Cancer Center Faculty Publications
Significance: Precise imaging of tumor metabolism with its vascular microenvironment becomes emerging critical for cancer research because increasing evidence shows that the key attribute that allows a tumor to survive therapies is metabolic and vascular reprogramming. However, there are surprisingly few imaging techniques available to provide a systems-level view of tumor metabolism and vasculature in vivo on small animals for cancer discoveries.
Aim: We aim to develop a new multi-parametric microscope that can faithfully recapitulate in vivo metabolic and vascular changes with a wide field of view and microscope-level resolution to advance cancer-related investigations. To maximize the ease and accessibility …
Discovering My Sonic Identity Through Intent And Self-Belief: A Portfolio Of Compositions, Addison J. Bird
Discovering My Sonic Identity Through Intent And Self-Belief: A Portfolio Of Compositions, Addison J. Bird
Theses and Dissertations--Music
An analysis and overview of a master’s degree electroacoustic composition portfolio. These works represent significant benchmarks in terms of musical development and composer intent. Each piece is analyzed for its musical methods and inspirations as well as the non-musical ideas surrounding them. The pieces covered are a mixture of fixed media electroacoustic works and live electronic works incorporating popular and folk music influences.
Astrovascular Decoupling In Awake 5×Fad Mice Is Associated With Reduced Astrocytic Calcium, Ruei-Lung Lin, Sophiya L. Sims, Nicholas A. Wright, Léopoldine B. Galopin, Blaine Weiss, Susan D. Kraner, Jacquelyn E. Rhinehart, Ting-Hsuan Lu, Pradoldej Sompol, Christopher M. Norris, Olivier Thibault
Astrovascular Decoupling In Awake 5×Fad Mice Is Associated With Reduced Astrocytic Calcium, Ruei-Lung Lin, Sophiya L. Sims, Nicholas A. Wright, Léopoldine B. Galopin, Blaine Weiss, Susan D. Kraner, Jacquelyn E. Rhinehart, Ting-Hsuan Lu, Pradoldej Sompol, Christopher M. Norris, Olivier Thibault
Pharmacology and Nutritional Sciences Faculty Publications
INTRODUCTION
Evidence points to dysregulated Ca2+ in neurons and astrocytes in models of amyloidosis. While most of these data were obtained in vitro or in vivo under anesthesia, less work has investigated these variables in awake ambulating mice.
METHODS
Astrocytic Ca2+ fluctuations (GCaMP8f) were imaged concomitantly with vasoreactivity in S1 on a two-photon microscope during rest and ambulation. Single-cell resolution variables were extracted using continuous wavelet transform and traditional ΔF/F measures.
RESULTS
Along with increases in amyloid beta (Aβ) accumulation, we found significant reductions in measures of astrocyte functional connectivity, pairwise correlations, and network synchronicity in older 5×FAD …
Advancing Clinical Trial Readiness In White Matter Disease And Related Dementias: Key Steps For Future Research Progress, Pradoldej Sompol, Gregory A. Jicha, Jason D. Hinman, Adam M. Brickman, Steven M. Greenberg, Konstantinos Arfanakis, Marion S. Buckwalter, Irene Lorenzo Llorente, Jeff D. Williamson, Michael S. Wolf, Eric E. Smith, Aditi Gupta, Margaret E. Flanagan, Miguel A. Vazquez, Jeffrey M. Burns, S. Thomas Carmichael, Frank C. Barone
Advancing Clinical Trial Readiness In White Matter Disease And Related Dementias: Key Steps For Future Research Progress, Pradoldej Sompol, Gregory A. Jicha, Jason D. Hinman, Adam M. Brickman, Steven M. Greenberg, Konstantinos Arfanakis, Marion S. Buckwalter, Irene Lorenzo Llorente, Jeff D. Williamson, Michael S. Wolf, Eric E. Smith, Aditi Gupta, Margaret E. Flanagan, Miguel A. Vazquez, Jeffrey M. Burns, S. Thomas Carmichael, Frank C. Barone
Pharmacology and Nutritional Sciences Faculty Publications
White matter disease, a broad-spectrum term that covers various types of white matter lesions and degeneration, is strongly related to age-related neurodegenerative disorders including Alzheimer’s disease (AD), and vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer’s related dementias (ADRD). There is no specific treatment for white matter disease. Therefore, basic research and clinical studies are essential for future outcomes. Since its formation in 2020, the Albert Research Institute for White Matter and Cognition (ARIWMC) mission has been to support white matter research by providing a forum for communication where basic and clinical scientists meet to discuss and debate …
Forage News [2025-07], University Of Kentucky