Digital Commons Network^™

Anthelmintic Resistance In Equine Parasites: Mechanisms And Treatment Approaches, Jessica Scare Kenealy

Theses and Dissertations--Veterinary Science

Anthelmintic resistance of parasites infecting livestock animals is a global problem resulting in decreased animal welfare and production losses. Horses are not exempt from this issue as wide-spread anthelmintic resistance exists among the equine cyathostomins and Parascaris spp. Of the three drug classes available for treating equine intestinal helminths anthelmintic resistance, defined as less than 90-95% drug efficacy, exist to all three. New pharmaceutical control regimens and the elucidation of parasite drug response mechanisms are needed.

Two studies were carried out evaluating combination deworming regimens. A population of cyathostomins with known resistance to the benzimidazole (BZ) and pyrimidine drug classes …

Quantifying White-Tailed Deer Density And Its Impacts On Agricultural Systems, Jonathan A. Matthews

Theses and Dissertations--Forestry and Natural Resources

White-tailed deer (Odocoileus virginianus) commonly consume row crops, with yield losses often attributed to their browsing. Deer density and field morphology may predict yield losses within local areas. We sought to 1) determine the effects of deer browsing on corn and soybean yields and investigate if deer density or field morphology correlated to yield loss in western Kentucky, and 2) compare pellet-based distance sampling to game camera surveys to determine if a distance sampling technique could accurately estimate deer density during the growing season. Overall, deer reduced corn and soybean yields on one-half of surveyed properties. Deer density …

Modulation Of Inflammatory Cytokine, Chemokine, And Toll-Like Receptor Genes And Transcriptome Analysis Of Equine Endothelial Cells Following Infection With Equid Herpesvirus-1, And Equine Arteritis Virus., Saranajith Wangisa Dunuwille

Theses and Dissertations--Veterinary Science

EHV-1 is a double-stranded DNA virus whereas EAV is a positive sense, single-stranded RNA virus. Therefore, genetically, they are very different from one another. However, both these viruses are endotheliotropic and thus, infect and replicates in equine endothelial cells resulting in vasculitis. Vasculitis is central to the pathogenesis of these two viruses. Thus, the main objective of this thesis was to investigate the inflammatory and innate immune responses of EECs that contribute towards the development of vasculitis following infection with EHV-1 and EAV in-vitro. Since proinflammatory cytokines and chemokines produced by endothelial cells play a significant role in the …

Evaluating Reforestation Options For Surface Mines In Appalachia, Joseph Frederick

Theses and Dissertations--Forestry and Natural Resources

During the last century coal extraction has degraded ecosystems in Appalachia, converting forested land into other cover types that have a diminished capacity to naturally progress to later stages of succession. This projects objective was to examine two options for land-use that can assist in returning the reclaimed surface mines to forested cover types, with increased ecosystem services, and a potential for economic gain.

This project examined a biomass plantation and an American chestnut trial. In the biomass trial, greatest heights for American sycamore (12.3 m) and black locust (8.0 m) were found in the fertilizer plots. Mean individual tree …

Mechanisms Of Type-I Ifn Inhibition: Equine Herpesvirus-1 Escape From The Antiviral Effect Of Type-1 Interferon Response In Host Cell, Fatai S. Oladunni

Theses and Dissertations--Veterinary Science

Equine herpesvirus-1 (EHV-1) is one of the most important and prevalent viral pathogens of horses causing a major threat to the equine industry throughout most of the world. EHV-1 primarily causes respiratory disease but viral spread to distant organs enables the development of more severe sequelae; abortion and neurologic disease. In order to produce disease, EHV-1 has to overcome the innate barrier of the type-I interferon (IFN) system in host cells. However, the underlying mechanisms employed by EHV-1 to circumvent the type-I IFN response in host cells are not well understood. In this project study, using molecular techniques, we explored …

Martin School Alumni Survey, Carl Sims

MPA/MPP/MPFM Capstone Projects

The Martin School of Public Policy and Administration is subject to reaccreditation from the Network of Schools of Public Policy, Affairs, and Administration (NASPAA) every seven years. To initiate the reaccreditation process, the Martin School must conduct a programmatic self-study that analyzes the program’s mission, governance, faculty, students, competencies, resources, and communication. The self-study is beneficial not only for the purpose of reaccreditation but also can better inform the school’s strategic planning process

To assist in providing the self-study relevant data, the Martin School can solicit information from its alumni. Alumni data can be used to establish how well the …

Enhanced Efficiency Nitrogen Formulation Effect On Grass-Legume Pasture Productivity, Kathryn Marie Payne

Theses and Dissertations--Plant and Soil Sciences

The use of nitrogen (N) fertilizer is generally restricted on mixed species forage systems due to its stimulatory effect on grasses which increases competition with legume species. Reduced legume growth from this competition can compromise forage nutritive value and prospective yields. The controlled-release nature of several enhanced efficiency fertilizer N products holds the potential to improve legume persistence in mixed species pastures while providing supplemental N required by the grass component. The studies contained in this dissertation evaluated the effect of different enhanced efficiency N formulations (ATU, ESN, methylene urea, SuperU, and a 75% ESN: 25% urea blend) and untreated …

Long-Term Land Management Practices And Their Effect On Soil Health And Crop Productivity, Thomas Joseph Muratore Jr.

Theses and Dissertations--Plant and Soil Sciences

Agricultural intensification reliant on monocrops could change soil health in a way that does not support maximum crop productivity. Twenty-nine-year-old no-till field plots at the University of Kentucky Spindletop research farm showed a significant reduction in corn yields from continuous corn plots compared to those from plots in various types of rotation. The objective of this study was to determine what role soil microbes might play in yield reduction and how management and time effects microbial community structure. Samples were collected from the following treatments: continuous corn (CC), continuous soybean (SS), a 2-year corn/soybean rotation (CCSS), Corn in rotation with …

Effects Of Abiotic Stresses On Sorbitol And Ribitol Accumulation And Sorbitol Biosynthesis And Metabolism In Tomato [Solanum Lycopersicum L.], Afaf Almaghamsi

Theses and Dissertations--Plant and Soil Sciences

Abiotic stresses are responsible for limiting crop production worldwide. Among diverse abiotic stresses, drought and salinity are the most challenging. Plants under these conditions have diverse strategies for tolerating stress. Osmotic adjustment and osmoprotection occur in plants during salinity and drought stress through accumulation of compatible solutes to a high level without interfering with cellular metabolism. Polyols (sugar alcohols) including sorbitol and ribitol are one such class of compatible solutes. Using plants of wild-type (WT) and three genetically-modified lines of tomato (Solanum lycopersicum cv. ‘Ailsa Craig’), an empty vector line ‘TR22’, and 2 sdh anti-sense lines ‘TR45’, and ‘TR49’ …

Metadata-Based Image Collecting And Databasing For Sharing And Analysis, Xi Wu

Theses and Dissertations--Computer Science

Data collecting and preparing is generally considered a crucial process in data science projects. Especially for image data, adding semantic attributes when preparing image data provides much more insights for data scientists. In this project, we aim to implement a general-purpose central image data repository that allows image researchers to collect data with semantic properties as well as data query. One of our researchers has come up with the specific challenge of collecting images with weight data of infants in least developed countries with limited internet access. The rationale is to predict infant weights based on image data by applying …

Relation Prediction Over Biomedical Knowledge Bases For Drug Repositioning, Mehmet Bakal

Theses and Dissertations--Computer Science

Identifying new potential treatment options for medical conditions that cause human disease burden is a central task of biomedical research. Since all candidate drugs cannot be tested with animal and clinical trials, in vitro approaches are first attempted to identify promising candidates. Likewise, identifying other essential relations (e.g., causation, prevention) between biomedical entities is also critical to understand biomedical processes. Hence, it is crucial to develop automated relation prediction systems that can yield plausible biomedical relations to expedite the discovery process. In this dissertation, we demonstrate three approaches to predict treatment relations between biomedical entities for the drug repositioning task …

Depth Enhancement And Surface Reconstruction With Rgb/D Sequence, Xinxin Zuo

Theses and Dissertations--Computer Science

Surface reconstruction and 3D modeling is a challenging task, which has been explored for decades by the computer vision, computer graphics, and machine learning communities. It is fundamental to many applications such as robot navigation, animation and scene understanding, industrial control and medical diagnosis. In this dissertation, I take advantage of the consumer depth sensors for surface reconstruction. Considering its limited performance on capturing detailed surface geometry, a depth enhancement approach is proposed in the first place to recovery small and rich geometric details with captured depth and color sequence. In addition to enhancing its spatial resolution, I present a …

Experiencing Displacement And Statelessness: Forced Migrants In Anse-À-Pitres, Haiti, Daniel Joseph

Theses and Dissertations--Anthropology

In 2013, the Dominican state ruled to uphold a 2010 constitutional amendment that stripped thousands of Dominicans of Haitian origin of their citizenship and forced them to leave the country during summer 2015. About 2,200 of these people became displaced in Anse-à-Pitres, where most took up residence in temporary camps. I use the term forced migrants or displaced persons interchangeably to refer to these people. Many endure challenges in meeting their daily survival needs in Haiti, a country with extreme poverty, considerable political instability, and still in the process of rebuilding itself from the devastating earthquake of 2010. Drawing on …

Resilience And Adaptation In A World System Periphery: Long-Term Perspectives From The Lake Atitlan Basin, Highland Guatemala 600 Bc – 1600 Ad, Gavin R. Davies

Theses and Dissertations--Anthropology

The Lake Atitlan Basin of highland Guatemala boasted fertile soils and was rich in natural resources, making it an attractive area for permanent settlement. However, the region lacked a number of important items, such as salt, cotton, and obsidian, all of which had to be obtained through trade. Good agricultural land was also scarce in certain parts of the lake and the steep hillslopes were easily eroded, making it necessary for communities to maintain access to emergency supplies of corn. Lake Atitlan’s communities were therefore highly dependent on exchanges with neighboring groups who occupied contrasting ecological zones, especially those in …

Spinal Kappa Opioid Receptor Activity Inhibits Adenylyl Cyclase-1 Dependent Mechanisms Of Chronic Postoperative Pain, Lilian Custodio

Theses and Dissertations--Physiology

Chronic postoperative pain impacts millions of individuals worldwide that undergo a variety of surgical procedures. Opioids remain the mainstay analgesics of acute and perioperative pain; however, prolonged opioid therapy may lead to life-threating adverse effects, tolerance, dependence, and addiction. Therefore, unraveling the cellular mechanisms that drive persistent pain states and opposing endogenous analgesia provided by opioid receptor signaling, may lead to novel analgesics. Evidence suggests that tissue injury leads to increased sensitization of the spinal cord nociceptive neurons which increases susceptibility to chronic pain via an N-methyl-D-aspartate (NMDA) receptor activation of calcium-sensitive adenylyl cyclase isoform 1 (AC1). This phenomenon, named …

Targeting Maladaptive Plasticity After Spinal Cord Injury To Prevent The Development Of Autonomic Dysreflexia, Khalid C. Eldahan

Theses and Dissertations--Physiology

Vital autonomic and cardiovascular functions are susceptible to dysfunction after spinal cord injury (SCI), with cardiovascular dysregulation contributing to morbidity and mortality in the SCI population. Autonomic dysreflexia (AD) is a condition that develops after injury to the sixth thoracic spinal segment or higher and is characterized by potentially dangerous and volatile surges in arterial pressure often accompanied with irregular heart rate, headache, sweating, flushing of the skin, and nasal congestion. These symptoms occur in response to abnormal outflow of sympathetic activity from the decentralized spinal cord typically triggered by noxious, yet unperceived nociceptive stimulation beneath the level of lesion. …

Variability In Plasma Concentrations Of Methylprednisolone 6 Days After Intrasynovial Injection Of Methylprednisolone Acetate In Racing Horses: A Field Study, Jacob Machin, W. Duer, G. Maylin, C. K. Fenger, D. Wilson, M. Ivey, B. Berthold, S. Allison, Thomas Tobin

Veterinary Science Faculty Publications

Background: Methylprednisolone (MP) acetate is a commonly used corticosteroid for suppression of inflammation in synovial structures in horses. Its use is often regulated in equine sports by plasma MP concentrations. Objectives: To describe variability in MP plasma concentrations after MP acetate injection in different synovial structures and with co-administration with hyaluronic acid (HA). Study design: Field study in actively racing horses in three disciplines (Thoroughbred, Standardbred and Quarter Horse). Methods: Seventy-six horses (15 Thoroughbreds, 20 Standardbreds and 41 Quarter Horses) were included in the study. Injection of any synovial structure with a total body dose of 100 mg MP acetate …

Role Of Mcp-1 And Ccr2 In Ethanol-Induced Damage In The Developing Brain, Kai Zhang

Theses and Dissertations--Pharmacology and Nutritional Sciences

Fetal alcohol spectrum disorders (FASD) are caused by alcohol exposure during pregnancy and is the leading cause of mental retardation. Alcohol exposure during development results in the loss of neurons in the developing brain. The underlying molecular mechanisms are unclear and there currently is no cure for FASD. Ethanol-induced neuronal death is accompanied by neuroinflammation. Chemokine monocyte chemoattractant protein 1 (MCP-1) and its receptor C-C chemokine receptor type 2 (CCR2) are critical mediators of neuroinflammation and microglial activation. Using a third trimester equivalent mouse model of ethanol exposure, we found that treatment of Bindarit (MCP-1 synthesis inhibitor) and RS504393 (CCR2 …

Neuropsychological Correlates Of Striatal Dopaminergic Dysfunction In Parkinson’S Disease, Brittany D. Walls

Theses and Dissertations--Psychology

Parkinson’s disease (PD) is a common neurodegenerative disorder associated with dysfunction of the basal ganglia, which contributes to a range of motor, cognitive, and affective symptoms. Striatal dopaminergic deficits are one of the core pathological mechanisms thought to contribute to the extra-motor (i.e., cognitive and affective) symptoms in early PD. The present study investigated the relationship between striatal dopaminergic integrity and cognition in 21 patients with PD and 21 age and education matched controls. Each individual underwent dopamine transporter (DaT) imaging with single photon emission computed tomography (SPECT) (i.e., DaTscan) and standardized neuropsychological testing. Strong positive associations were found between …

Women Into Advanced Manufacturing: Can Community College Open This Door?, Carissa Bradley Schutzman

Theses and Dissertations--Educational Policy Studies and Evaluation

Women still rarely choose to seek employment in advanced manufacturing. Lack of familiarity with manufacturing jobs and education programs, lack of role models, and too few experiential opportunities contribute to women not choosing manufacturing jobs as well as other jobs traditionally held by men (Reha, Lufkin, & Harrison, 2009; St. Rose & Hill, 2013; Starobin & Laanan, 2008). Nontraditional jobs for women often provide higher wages and more opportunity for advancement than traditional jobs for women. This study is a qualitative thematic narrative analysis of factors that influenced women who chose an advanced manufacturing program at a community college to …

Endowments Of Higher Education Institutions And Individual Income Tax Policy: Wealth Erosion From A Loss In Charitable Contributions, Jennifer W. Siebenthaler

Theses and Dissertations--Educational Policy Studies and Evaluation

The most significant tax overhaul bill in over thirty years was enacted in 2017 and expected to have wide-ranging effects. The Tax Cuts and Jobs Act includes numerous policies that directly and indirectly impact the higher education sector and the effect to endowments was not addressed in the public debate leading up to enactment. Unlike expendable gifts, a reduction in endowment contributions has a cumulative effect because a gift to an endowment can benefit all subsequent years. Each year following a contribution, investment income earned on the original gift is available for spending and benefits escalate over time in amount, …

A Quasi-Experimental Study Of Middle Level Student Engineering Understanding Pre-And Post-Treatment, Emily Driessen

Theses and Dissertations--Science, Technology, Engineering, and Mathematics (STEM) Education

This qualitative quasi-experimental study analyzed middle-level students’ understanding of engineering before and after instruction. Students from four teachers were examined. Before and after instruction, all students completed the Draw an Engineer Test (DAET) and the Views of Nature of Engineering (VNOE) survey. Additionally, sixteen students (eight girls and eight boys) from each group (Treatment and Comparison) were interviewed before and after instruction. Findings revealed that after instruction (1) many students viewed engineers as makers/builders/workers (just as they did pre-instruction), however, the percentage of students who listed engineers as inventors, designers, and creators increased; (2) fewer students from both groups noted …

A Kentucky Pioneer In Music Therapy: An Oral History On The Life And Career Of Lorinda Jones, Emma Powers

Theses and Dissertations--Music

Lorinda Jones, MT-BC, is the longest practicing music therapist in Kentucky. She began her work as a music therapist in 1995 and built a private practice, which expanded over the course of the next 20 years to include services in 16 counties. Ms. Jones’ perspective on the growth of music therapy, both within the state and nationwide, as well as her extensive knowledge of Appalachian folk music, makes her an invaluable resource to Kentucky music therapists. The purpose of this study was to present a historical account of the life and career of Lorinda Jones, to gain her perspective on …

Finding The “Tech” In Technique: A Pedagogical Approach To Electroacoustic Concert Percussion Performance Practice, William Brady Harrison Ii

Theses and Dissertations--Music

Premise and Objectives

In our increasingly technology driven society, the impact of technology touches nearly every aspect of our lives in some form or another. This has been acutely felt within the world of percussion, with electroacoustic works representing perhaps the most rapidly expanding area of concert percussion over the last twenty years. Electroacoustic music couples electronic technology with traditional acoustic instruments and/or performance practices.

Broadly, this paper outlines a systematic approach to teaching electroacoustic performance practice, based on elements found in a cross-section of percussion literature. In using such an approach, not only does each student become more capable …

When The Inhuman Becomes Human: An Examination Of The Musical Portrayal Of The Robot In Twenty-First Century Science-Fiction Cinema Through An Analysis Of The Film Scores Of Automata, Ex Machina, And The Machine, Rebecca Ann O'Brien

Theses and Dissertations--Music

Science fiction film has been telling stories about artificial anthropomorphic robots and androids for almost a hundred years, spawning films, such as Metropolis (1927), Ghost in the Shell (1951), and Blade Runner (1982). Each of these science-fiction films was complemented by a musical score that helped to create an onscreen world dominated by a dystopian view of the future. Influenced by the generations of prior science-fiction films, Automata (2014), The Machine (2013), and Ex Machina (2015) are all concerned with the same narrative in which humanity is in decline while artificial robots are rising up and experiencing life in a …

Morten Lauridsen’S Choral Cycle, Nocturnes: A Conductor’S Analysis, Margaret B. Owens

Theses and Dissertations--Music

Morten Lauridsen is one of the most prolific composers of choral music in the 20th and 21st centuries. His characteristic tone is both readily identifiable and timeless. Works such as Lux Aeterna, Les Chansons des Roses, “Sure on this Shining Night” (from Nocturnes) , and “O magnum mysterium” have solidified his place as one of the most important compositional voices in modern choral music.

Lauridsen’s most often-performed choral works have been individual movements excerpted from his larger choral works, due to their accessibility for advanced high school and collegiate choirs. For example, the popular “Dirait-on” comes from the …

Exposing Corruption In Progressive Rock: A Semiotic Analysis Of Gentle Giant’S The Power And The Glory, Robert Jacob Sivy

Theses and Dissertations--Music

English progressive rock band Gentle Giant is catalogued under the progressive (or “prog”) rock genre for a variety reasons, including unique instrumentation, virtuosity, and interesting/unconventional musical attributes. The complexity of their music is often warranted by the sophisticated concepts behind their albums and the deep messages of their songs. The Power and the Glory (TPatG), Gentle Giant’s sixth studio album, is a concept album that emphasizes the rise and corruption of power. What makes their music, especially TPatG, worthy of scholarly attention beyond the simple examination of the compositional techniques employed is the way in which the …

Where We Belong: Spatial Imagining In American Women’S Life Narratives, 1859-1912, Gokce Tekeli

Theses and Dissertations--English

Where We Belong: Spatial Imagining in American Women’s Life Narratives, 1859-1912, studies three marginalized and disadvantaged American women’s self-life narratives during a transitional period in American history. In this dissertation, I am taking an interdisciplinary approach. Where We Belong borrows from social geography, new materialism, and autobiography studies in order to complicate critical discussions of women’s space and place in nineteenth-century women’s self-life narratives. Each chapter of Where We Belong presents a case study with the goal to provide a broader understanding of women’s strategies of belonging due to and despite their spatial exclusions. The overarching emphasis in each …

Identity, Spectacle, And Embodiment In Social Protest, Craig Alan Crowder

Theses and Dissertations--English

This dissertation examines the way rhetorical performances of identity function within a social movement. Examining the University of Kentucky chapter of a campus activist organization, United Students Against Sweatshops, I argue that embodied performances of identity often leverage spectacle in disruptive ways and work not only to solidify activists’ identities as part of a social movement but ultimately help to create solidarity within the movement, thereby working toward movement objectives. Historically under-examined in social movement literature in the rhetoric and composition tradition, identity performance examples are taken from an oral history project and archival materials to show how identity is …

The Revolt Against Mourning: Woolf, Joyce, Faulkner, And Beyond, Andrew Leo Beutel

Theses and Dissertations--English

The Revolt against Mourning calls into question the widespread critical alignment of literary modernism with Freudian melancholia. Focusing instead on “mourning,” through close readings of Virginia Woolf’s Mrs. Dalloway, James Joyce’s Ulysses, and William Faulkner’s The Sound and the Fury, I demonstrate how their depictions of this notion overturn both its traditional and contemporary understandings. Whereas Freud conceives mourning as a psychic labor that the subject slowly and painfully carries out, Woolf, Joyce, and Faulkner convey it as a destabilizing, subversive, and transformative force to which the subject is radically passive. For Freud, mourning is a matter …