Early Acid/Base And Electrolyte Changes In Permanent Middle Cerebral Artery Occlusion: Aged Male And Female Rats, Sarah R. Martha, Lisa A. Collier, Stephanie M. Davis, Sarah J. Goodwin, David Powell, Doug Lukins, Justin F. Fraser, Keith R. Pennypacker

Neurosurgery Faculty Publications

BACKGROUND: Early changes in acid/base and electrolyte concentrations could provide insights into the development of neuropathology at the onset of stroke. We evaluated associations between acid/base and electrolyte concentrations, and outcomes in permanent middle cerebral artery occlusion (pMCAO) model.

METHODS: 18-month-old male and female Sprague-Dawley rats underwent pMCAO. Pre-, post- (7 min after occlusion), and at 72 hr of pMCAO venous blood samples provided pH, carbon dioxide, oxygen, glucose, hematocrit, hemoglobin, and electrolyte values of ionized calcium, potassium, and sodium. Multiple linear regression determined predictors of infarct and edema volumes from these values, Kaplan-Meier curve analyzed morality between males and …

North Fork: Whitesburg Tributaries Watershed Plan, Letcher County, Ky, Kentucky Water Resources Research Institute

KWRRI Research Reports

Crafts Colly, Sandlick, and Dry Fork are tributaries to the North Fork of the Kentucky River. The three tributaries are located immediately north of the North Fork of the Kentucky and flow southward into the river within or near the City of Whitesburg in Letcher County, Kentucky. Letcher County is found in the Appalachian coalfields of southeastern Kentucky.

To improve water quality in the Kentucky River, water quality impairments in the upper reaches of the watershed must be addressed. In focusing efforts in Crafts Colly, Sandlick, and Dry Fork, three headwater tributaries of the North Fork Kentucky River, pollution loading …

2019 Kentucky River Watershed Watch: Annual Report, Malissa Mcalister, Steven Evans

Kentucky River Watershed Watch

No abstract provided.

In Re: Patentability Of The Peltzer Inventions, Brian L. Frye

Law Faculty Scholarly Articles

The motion picture Gremlins (1984) stars Hoyt Wayne Axton (1938-1999) as Randall Peltzer, a prolific inventor with persistent cash-flow problems. Among other things, the motion picture discloses many of Peltzer's inventions, including the "Bathroom Buddy," the "Peltzer Smokeless Ashtray," and the "Peltzer Pet." This essay takes the form of an opinion letter evaluating the patentability ofPeltzer's inventions.

From Petri Dish To Main Dish: The Legal Pathway For Cell-Based Meat, Brian P. Sylvester, Nathan A. Beaver, Kara Schoonover, Jonathan I. Tietz

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

Meat grown outside an animal is no longer simply science fiction, and the market is poised for introduction of a variety of so-called cell-based meat products. Commercializing these products will require a clear regulatory path forward. In this Article, we explore that legal pathway. We introduce the concepts of cellular agriculture and cell-based meat, including the science, the state and history of the industry, and the general regulatory background, in which the USDA and FDA are the major players. Further, we explore in particular regulatory aspects of food safety and labeling in the context of cell-based meat. Overall, we contend …

The Untapped Potential Of Bourbon Tourism: Regulatory Effects On Kentucky’S Agritourism Industry, Andrew Bocanumenth

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Energy, Electricity And Smart Grids In Latvia And Portugal – Developments And Concerns, Rafael Leal-Arcas, Filipa Santos, Danai Papadea

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Plugging Problems: How States In The Ohio River Basin Can Address Orphan Oil And Gas Wells, Connor Hicks

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Planting The Seed: A Proposal For A Farm Operation Test Under The Fsma Produce Safety Rule, Sophia Kruszewski, Samuel Ingraham

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

What The Brita Won’T Purify: Why Kentucky Is In Need Of Strict Pharmaceutical Disposal Regulations, Caroline K. Mitchell

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Recipes For Anger Appeals: A Systematic Review, Tianen Chen

Theses and Dissertations--Communication

Although there is an increasing use of anger appeals in communication research, scholars have yet to fully explore the causes of anger. Anger is elicited in situations where individuals perceive that their desired goals are blocked or needs are not fulfilled (Harmon-Jones & Harmon-Jones, 2016). Using Maslow’s hierarchy of human needs model (Maslow, 1943), the current study aims to systematically review communication studies on anger appeals to synthesize and categorize the violations of goals/needs that have been studied or utilized to elicit anger. A comprehensive literature search was conducted in eight relevant databases: ProQuest Dissertation & Thesis Global, Web of …

Effect Of Different Fat Sources And Vitamin E Isoforms/ Levels On Carcass Characteristics, Meat Quality, And Belly/Bacon Characteristics Of Pigs Grown To Heavy Slaughter Weights (>150kg), Marlee Kelley

Theses and Dissertations--Animal and Food Sciences

Two separate studies were conducted to evaluate the potential interaction of fat sources and vitamin E (VE) on heavy slaughter weights. In Study 1, a total of 64 individually-fed pigs (28.41 ± 0.83 kg) were randomly assigned to 8 dietary treatments in a 4×2 factorial arrangement. Fat treatments included cornstarch (CS), tallow (TW), corn oil (CO), and coconut-oil (CN). VE treatments were dietary alpha-tocopheryl-acetate (ATA) at 11 and 200 ppm. In Study 2, a total of 72 individually fed pigs (28.55 ± 1.16 kg) were randomly assigned to 12 dietary treatments in a 2 × 6 factorial arrangement. Fat treatments …

Optimizing Animal Welfare In Commercial Laying Hens Through Novel Management Practices And Farm Manager Evaluation, John R. Brunnquell

Theses and Dissertations--Animal and Food Sciences

The commercial production of pasture and free-range eggs in the United States is expanding rapidly. According to the United States Department of Agriculture Agricultural Management Assistance, in May of 2019 there were 2.6M pasture hens and 4.5M free-range hens representing 1.9% of the nation’s laying flock. There is little industry and/or academic experience with this style of production in the United States. Programs such as the European Layer Training Initiative (ELTI), which emerged in 2019, have tried to fill this void but participation from the US was low. The principal sources for guidance of commercial free-range egg production in the …

Impact Of Ergot Alkaloid And Estradiol 17b On Whole-Body Protein Turnover And Expression Of Mtor Pathway Proteins In Muscle Of Cattle, Taylor Dawn Ferguson

Theses and Dissertations--Animal and Food Sciences

Beef cattle consuming endophyte infected tall fescue typically exhibit reduced performance in terms of both decreased dry matter intake (DMI) and growth rates. It has been suggested that lower concentrations of circulating IGF-1 (an important stimulator of the mTOR pathway and ultimately protein synthesis), as observed with consumption of ergot alkaloids, contribute to reduced growth rates. The objective of the current study was to determine if fescue-derived alkaloids decrease muscle protein synthesis though inhibitory action on the mTOR pathway via a direct effect on signal proteins, and if these negative effects can be alleviated by implantation with anabolic agents. Thirty-two …

The Disappearing Act: How To Prevent The Decline Of Black Farmers In The United States, Jordan M. Jennings

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Ethanol Induced Neurotoxicity Through Dysregulation Of Ampk In A Fetal Alcohol Syndrome Model, Jessica Gebhardt

Theses and Dissertations--Medical Sciences

Ethanol consumption during pregnancy is rising in the U.S., including the rate of binge drinking. It is reported around 1 in 27 women engage in binge drinking activities while pregnant. The third trimester is a sensitive period of neuronal growth in which ethanol induced neurotoxicity can cause many harmful effects including Fetal Alcohol Spectrum Disorders. It has been shown that ethanol decreases the activity of AMPK through increasing lipid peroxidation, both of which are correlated to neurotoxicity. AICAR is a synthetic analog of AMP which significantly increases AMPK activity and may have beneficial effects in an organotypic hippocampal model of …

Hospital-Based Safe To Sleep Intervention To Decrease Sleep-Related Infant Deaths In St. Louis, Missouri, Olivia M. Pokoski

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The city of St. Louis in Missouri has an elevated infant mortality rate compared to St. Louis County, Missouri, and the United States. When controlling for race, black or African American infants are over twice as likely to die before their first birthday compared to their white counterparts. Two of the leading causes of infant death are sleep-related causes and sudden infant death syndrome (SIDS) which occur if the infant is placed in an unsafe sleeping environment. To address this burden Affinia Healthcare, Barnes Jewish Hospital, and St. Mary’s Hospital have decided to implement a hospital-based Safe to Sleep campaign. …

Anterior Cruciate Ligament Injury-Induced Alterations In Inflammation And Muscle Physiology, Emily R. Hunt

Theses and Dissertations--Rehabilitation Sciences

Long term weakness and atrophy of the quadriceps muscle are a direct result of anterior cruciate ligament (ACL) injuries and persist for up to 10 years post injury. Muscle atrophy ensues regardless of ligamentous reconstruction surgery, indicating that muscle atrophy following injury is a function of the ligament rupture and not reconstruction surgery. Elucidating the mechanisms underlying quadriceps atrophy following ACL rupture is crucial for developing interventions to restore proper quadriceps size and mitigate weakness thereby allowing for improved patient function. In addition to understanding the specific mechanisms that contribute to quadriceps atrophy following ACL rupture, the timing of atrophic …

Determining The Role Of Satellite Cells During Skeletal Muscle Adaptation, Davis A. Englund

Theses and Dissertations--Rehabilitation Sciences

Physical inactivity, advancing age, limb immobilization, degenerative diseases and various systemic diseases (many cancers, sepsis, HIV, COPD, kidney disease) all lead to skeletal muscle wasting. The loss of muscle mass is of major clinical importance because it leads to an increased risk for morbidity, disability, and the loss of independence; collectively contributing to a substantive increase in healthcare utilization and cost. The prevalence of cachexia (disease-induced muscle wasting) can reach as high as 80% in certain patient populations and the average cost per hospital stay is $4,641 more than in non-cachectic patients. Direct healthcare costs attributable to sarcopenia were estimated …

Using Transcranial Direct Current Stimulation To Improve Naming Ability In Post-Stroke Aphasia: Evaluating Evidence And Optimizing Outcomes, Mohammed Alharbi

Theses and Dissertations--Rehabilitation Sciences

Introduction. Aphasia is a devastating acquired language disorder that affects about one third of stroke survivors. Aphasia can severely affect quality of life and can be associated with economic burdens due to the need for long-term communication rehabilitation. Traditional aphasia therapies are known to be effective; however, progress is often slow and limited in severe cases – full restoration of communication abilities is rarely achieved. Thus, there is a critical need for therapeutic solutions that can reduce the associated burden of aphasia. Transcranial direct current stimulation (tDCS) is a non-invasive and inexpensive neuromodulation technique that has the potential to boost …

Prevalence Of Restricted Spirometry Within Two Eastern Kentucky Counties A Cross Sectional Study, Quincy Bascombe

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objective: This study examines the prevalence of restrictive spirometry in Eastern Kentucky and its association among men and women with various demographic and exposure (occupational and environmental) factors.

Methods: A cross sectional, cluster sample (N = 685) of participants from Letcher and Harlan Counties, aged 21 and over, answered a questionnaire focused on risk factors for respiratory health outcomes including questions on demographic, health, occupational, and environmental exposures variables. Pulmonary function tests were administered to all participants with no significant cardiovascular or cerebrovascular events within the past 30 days. Log-binomial regression was used to calculate prevalence ratios (PRs) …

Policy Analysis Of California Senate Bill 1138: Mandating Plant-Based Meal Options In Hospitals And Prisons, David Morton

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Obesity, chronic disease, and poor nutrition are prevalent in the United States while healthcare costs rise. Nutritional research advancements have suggested the healthfulness of plant-based diets. In 2018, the California state senate passed Senate Bill 1138, requiring plant-based meal options in hospitals and prisons. This paper sought to examine the context surrounding the bill, determine the appropriateness of the bill, and recommend next steps for nutritional policies in the United States. In a review of the literature, malnutrition in hospitals and prisons is highly prevalent, and state governments have already made efforts to improve their citizens’ nutrition. In this analysis, …

Implementing The Be Proud! Be Responsible! Program In Wolfe County Public Schools, Casey Gill

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Kentucky’s teen pregnancy rate is higher than the national average, and Wolfe County has one of the highest rates of teen pregnancy in the state. Teen pregnancy causes adverse health effects for both mother and baby. Teen mothers have a higher likelihood of dropping out of high school, increased health problems related to pregnancy such as preterm labor and preeclampsia, increased risk of being a single parent, and lower income and SES status. The baby is also affected, with an increased risk of living in a single parent household, and living in poverty. The Kentucky River District Health Department plans …

Analysis Of Health Survey Data To Address Topics In Environmental And Public Health, Nimish Valvi

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Introduction: Manganese is an essential trace element that can cause adverse health effects with deficiency and in excess amounts. The purpose of this study is to determine the asscociation of blood manganese levels and the prevalence of myocardial infarction, stroke, and renal dysfunction in a general US population.

Methods: Data were used from the National Health and Nutritional Examination Survey (NHANES) of non-institutionalized US adults 20 years and older using the 2011-2012, 2013-2014, and 2015-2016 survey cycles (n=16629). Weighted multivariable logistic regression models adjusted for age, race/ethnicity, sex, and poverty income ratio (PIR), were used to determine the association of …

Differential Effects Of Criteria For Increasing Delay Intervals In Progressive Time Delay, Kaitlin O'Neill

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

The purpose of the study was to compare the differential effects of response-independent and response-dependent criteria used to determine when to increase to the next delay interval in the progressive time delay (PTD) procedure. An adapted alternating treatments design was used to evaluate the relative efficiency of two variations of the PTD procedure when teaching expressive word identification to elementary-aged boys with moderate to severe disabilities, language impairments, and reading deficits. The participants’ school was closed due to a pandemic prior to completion of the study. Therefore, conclusions about results should be considered in light of this limitation. Results obtained …

Microbial Interactions Between Compost Bedded Pack Barn Bedding And Teat Exposure In Transition Dairy Cattle, Tanya Lynn France

Theses and Dissertations--Animal and Food Sciences

Compost bedded pack barns utilize composting methods which provide a soft surface for dairy cows to lie on. This requires optimal microbial growth, which may increase the exposure of mastitis-causing pathogens to the teats of early lactation animals. Bedding characteristics, bedding bacteria, and bacterial counts on the teat skin, teat ends, and in the milk of early lactation dairy cows housed on a compost bedded pack were assessed over a 6-month time. The main objective was to determine the relationship between environmental effects (bedding characteristics and weather conditions) and cow-level (teat skin, teat end, milk) bacteria counts over time in …

The Application Of The Food Safety Modernization Act’S Produce Safety Rule For Produce Auctions, Mari Schroeder

Theses and Dissertations--Animal and Food Sciences

Produce is a high-risk commodity that is associated with numerous foodborne outbreaks each year. The Food Safety Modernization Act’s Produce Safety Rule was designed to address these issues by requiring farms that grow, harvest, package, and/or hold produce to comply with science-based minimum guidelines. However, with the revival of the local food movement there is a subsequent flux in alternative food networks that handle produce but are not covered by this rule. Produce auctions represent only a fraction of these alternative food networks but are the focus of this study because of their interaction with the Plain community whose relationship …

The Role Of Feed Additives In Mitigating The Effect Of Stressors On Growth, Digestibility, Intestinal Morphology, Permeability, And Immune Response In Poultry, Yemi Olojede Burden

Theses and Dissertations--Animal and Food Sciences

Three experiments were conducted to evaluate the interactive effects of dietary supplements in birds exposed to different stressors, on growth performance, nutrient, and energy digestibility, antioxidant status, intestinal permeability, and immune status. The first study was conducted to evaluate the effect of a commercially available algae-based antioxidant, containing Selenium yeast (EconomasE™, EcoE) and two inorganic sodium sources (NaCl and NaCl+NaHCO3) on growth performance, nutrient and energy digestibility and utilization, antioxidant, and immune status of broilers challenged with oral gavage of dexamethasone (DEX). The inclusion of either of the sodium sources did not affect plasma corticosterone and antioxidant status levels, growth …

Monumental Questions And How We Honor Them, Melynda J. Price J.D., Ph.D.

Law Faculty Scholarly Articles

We are in another moment where who and how we memorialize is being reconsidered in communities small and large. My colleague, Zachary Bray, and I proposed this symposium to the Kentucky Law Journal because the topic reflected our shared interests in the debate over memorials and which historical narrative should triumph in the public square. We arrive at the question from different intellectual paths, but the common concern is over when and how stakeholders can and will revise that narrative through the regulation of monuments. These revisions often come in the form of calls for, it not outright, removal outhouse …

The Fragile Future Of Aquifer Storage And Recovery, Zachary A. Bray

Law Faculty Scholarly Articles

Buda, Texas-a small town that lies between Austin and San Antonio,

on the banks of Onion Creek and above the Edwards Aquifer-is perhaps

best known, though it is not particularly well known, as the "Wiener Dog

Capital of Texas." Buda's claim to this title is based upon its annual

dachshund races, which are opposed by the Dachshund Club of America

but lauded by locals, tourists, and the international press as an "event that

combines the pageantry of the Kentucky Derby and the excitement of

NASCAR with dachshunds, animals known for their small stature." Buda

is certainly unusual in relying so …