Digital Commons Network^™

Methods For The Assessment Of Cell Wall Composition In Miscanthus And Other 'Energy Grasses', Mark P. Robbins, G. G. Allison, E. Hodgson, C. Morris, S. Gill, I. S. Donnison

IGC Proceedings (1977-2023)

No abstract provided.

Non-Transgenic Crispr-Mediated Knockout Of Entire Ergot Alkaloid Gene Clusters In Slow-Growing Asexual Polyploid Fungi, Simona Florea, Jolanta Jaromczyk, Christopher L. Schardl

Computer Science Faculty Publications

The Epichloë species of fungi include seed-borne symbionts (endophytes) of cool-season grasses that enhance plant fitness, although some also produce alkaloids that are toxic to livestock. Selected or mutated toxin-free endophytes can be introduced into forage cultivars for improved livestock performance. Long-read genome sequencing revealed clusters of ergot alkaloid biosynthesis (EAS) genes in Epichloë coenophiala strain e19 from tall fescue (Lolium arundinaceum) and Epichloë hybrida Lp1 from perennial ryegrass (Lolium perenne). The two homeologous clusters in E. coenophiala—a triploid hybrid species—were 196 kb (EAS1) and 75 kb (EAS2), and …

Genomic Comparisons Of Persian Kurdish, Persian Arabian And American Thoroughbred Horse Populations, Navid Yousefi-Mashouf, Hassan Mehrabani-Yeganeh, Ardeshir Nejati-Javaremi, Ernest Bailey, Jessica L. Petersen

Maxwell H. Gluck Equine Research Center Faculty Publications

The present research aimed to characterize the Persian Kurdish horse population relative to the Persian Arabian and American Thoroughbred populations using genome-wide SNP data. Fifty-eight Kurdish, 38 Persian Arabian and 83 Thoroughbred horses were genotyped across 670,796 markers. After quality control and pruning to eliminate linkage disequilibrium between loci which resulted in 13,554 SNPs in 52 Kurdish, 24 Persian Arabian and 58 Thoroughbred horses, the Kurdish horses were generally distinguished from the Persian Arabian samples by Principal Component Analyses, cluster analyses and calculation of pairwise F_ST. Both Persian breeds were discriminated from the Thoroughbred. Pairwise F_ST between …

Aberrant Azin2 And Polyamine Metabolism Precipitates Tau Neuropathology, Leslie A. Sandusky-Beltran, Andrii Kovalenko, Devon S. Placides, Kevin Ratnasamy, Chao Ma, Jerry B. Hunt, Huimin Liang, John Ivan T. Calahatian, Camilla Michalski, Margaret Fahnestock, Laura J. Blair, April L. Darling, Jeremy D. Baker, Sarah N. Fontaine, Chad A. Dickey, Joshua J. Gamsby, Kevin R. Nash, Erin L. Abner, Maj-Linda B. Selenica, Daniel C. Lee

Sanders-Brown Center on Aging Faculty Publications

Tauopathies display a spectrum of phenotypes from cognitive to affective behavioral impairments; however, mechanisms promoting tau pathology and how tau elicits behavioral impairment remain unclear. We report a unique interaction between polyamine metabolism, behavioral impairment, and tau fate. Polyamines are ubiquitous aliphatic molecules that support neuronal function, axonal integrity, and cognitive processing. Transient increases in polyamine metabolism hallmark the cell’s response to various insults, known as the polyamine stress response (PSR). Dysregulation of gene transcripts associated with polyamine metabolism in Alzheimer’s disease (AD) brains were observed, and we found that ornithine decarboxylase antizyme inhibitor 2 (AZIN2) increased to …

Immunomodulatory Effects Of Azithromycin Revisited: Potential Applications To Covid-19, Vincent J. Venditto, Dalia Haydar, Ahmed K. Abdel-Latif, John C. Gensel, Michael I. Anstead, Michelle G. Pitts, Jarrod W. Creameans, Timothy J. Kopper, Chi Peng, David J. Feola

Pharmaceutical Sciences Faculty Publications

The rapid advancement of the COVID-19 pandemic has prompted an accelerated pursuit to identify effective therapeutics. Stages of the disease course have been defined by viral burden, lung pathology, and progression through phases of the immune response. Immunological factors including inflammatory cell infiltration and cytokine storm have been associated with severe disease and death. Many immunomodulatory therapies for COVID-19 are currently being investigated, and preliminary results support the premise of targeting the immune response. However, because suppressing immune mechanisms could also impact the clearance of the virus in the early stages of infection, therapeutic success is likely to depend on …

The Comparative Psychology Of Intelligence: Macphail Revisited, Michael Colombo, Damian Scarf, Thomas R. Zentall

Psychology Faculty Publications

No abstract provided.

Nutrients Intake By The Ile‐De‐France Lambs Fed Up With Diets Containing Sugar Cane Forage Variety Or Corn Silage, A. G. Silva Sobrinho, G. M. B. Moreno, A. G. Leão, C. M. B. Loureiro, A. A. M. Sampaio

IGC Proceedings (1977-2023)

No abstract provided.

Problems Of Grass Feed Quality Providing And Its Influence On Animals Health, Baiba Osmane, Aleksandrs Jemeljanovs, Jānis Blūzmanis

IGC Proceedings (1977-2023)

No abstract provided.

Use Of By‐Products Derived From Neem Tree (Azadirachta Indica) In Livestock Production, W. Z. Yang, B. N. Ametaj

IGC Proceedings (1977-2023)

No abstract provided.

Fodder Availability And Nutritive Value Of Two Sahelian Browse Plants: Acacia Senegal And Pterocarpus Lucens, H. O. Sanon, F. Ouattara, I. Ledin

IGC Proceedings (1977-2023)

No abstract provided.

Dna Repair Pathways In Cancer Therapy And Resistance, Lan-Ya Li, Yi-Di Guan, Xi-Sha Chen, Jin-Ming Yang, Yan Cheng

Toxicology and Cancer Biology Faculty Publications

DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The deregulation of DNA repair pathways is associated with the initiation and progression of cancer. As the primary anti-cancer therapies, ionizing radiation and chemotherapeutic agents induce cell death by directly or indirectly causing DNA damage, dysregulation of the DNA damage response may contribute to hypersensitivity or resistance of cancer cells to genotoxic agents and targeting DNA repair pathway can increase the tumor sensitivity to cancer therapies. Therefore, targeting DNA repair pathways may be a potential therapeutic approach for …

Role Of Italian Ryegrass In Feeding Rabbit And Meat Goose, Yutao Wang, Guorong Xin, Fangfang Xia, Zhijian Hu

IGC Proceedings (1977-2023)

No abstract provided.

Effects Of Conservative Tillage On The Productive Performance Of Hunnigreen On The Fallow Of Wheat Stubbles, Hai Wang, Kuanhu Dong

IGC Proceedings (1977-2023)

No abstract provided.

Silvopastoral Sheep And Cattle Production Systems In Pine Forest (Pinus Radiata Don.) Located In Subhumid Mediterranean Rangeland Of Chile, N. Fernando Squella, B. Felipe Squella

IGC Proceedings (1977-2023)

No abstract provided.

Study On Optimum Forage Cropping System At Reclaimed Tideland Of Central Provinces In Korea, J. S. Shin, W. H. Kim, S. H. Yoon, K. B. Lim, S. Seo

IGC Proceedings (1977-2023)

No abstract provided.

Impacts Of Agroforestry Production Systems With Ruminants In Cuba, M. Milera, S. Sánchez, G. Martín, J. Iglesias, J. Arece, G. Pentón, O. Alonso

IGC Proceedings (1977-2023)

No abstract provided.

Forage Crop Introduction In Chifeng Areas, Central East Of Inner Mongolia, China, Qingfeng Li

IGC Proceedings (1977-2023)

No abstract provided.

Environmental Efficiency In Mixed Crop Livestock Farming In India, K. A. C. H. A. Kothalawala, S. Kumar, H. Kothalawala

IGC Proceedings (1977-2023)

No abstract provided.

Agroforestry And Its Role In Soil Conservation And Erosion Protection, Atena Kabir, Y. Hematzade, H. Barani

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of The Use Of Mulberry Forage (Morus Alba) On The Performance Traits Of Swine Livestock, R. E. Almaguel, J. Ly, Carmen María Mederos, Elizabeth Cruz, G. Martín

IGC Proceedings (1977-2023)

No abstract provided.

Novel Influences Of Sex And Apoe Genotype On Spinal Plasticity And Recovery Of Function After Spinal Cord Injury, Lydia E. Strattan, Daimen R. Britsch, Chris M. Calulot, Rachel S. J. Maggard, Erin L. Abner, Lance A. Johnson, Warren J. Alilain

Sanders-Brown Center on Aging Faculty Publications

Spinal cord injuries can abolish both motor and sensory function throughout the body. Spontaneous recovery after injury is limited and can vary substantially between individuals. Despite an abundance of therapeutic approaches that have shown promise in preclinical models, there is currently a lack of effective treatment strategies that have been translated to restore function after SCI in the human population. We hypothesized that sex and genetic background of injured individuals could impact how they respond to treatment strategies, presenting a barrier to translating therapies that are not tailored to the individual. One gene of particular interest is APOE, which has …

Management As Factor Of Quali‐Quantitative Changes In Rangeland Communities North Western Santa Fe Province, Argentine, Guillermo Chiossone

IGC Proceedings (1977-2023)

No abstract provided.

Forage Productivity Of Flemingia Macrophylla Under Different Planting Density, Defoliation Management And Phosphorus Application In Chitwan, Nepal, Ram Prasad Ghimire, Naba R. Devkota, Kishore Prasad Kayastha

IGC Proceedings (1977-2023)

No abstract provided.

Diet Authentication In Lamb Meat Using Spectroscopic Methods, P. H. M. Dian, D. Andueza, J. Ballet, R. Jailler, M. Jestin, J. Pourrat, I. N. Prado, S. Prache

IGC Proceedings (1977-2023)

No abstract provided.

Productivity Of Designed Silvopastoral Systems In Five Agro‐Ecological Regions Of India, M. M. Roy, B. Ekambaram, K. S. Dutta, S. M. Taley, P. Tripathi

IGC Proceedings (1977-2023)

No abstract provided.

Piglet Immunization With A Spike Subunit Vaccine Enhances Disease By Porcine Epidemic Diarrhea Virus, Jieshi Yu, Chithra Sreenivasan, Tirth Uprety, Rongyuan Gao, Chen Huang, Ella J. Lee, Steven Lawson, Julie Nelson, Jane Christopher-Hennings, Radhey S. Kaushik, Eric Nelson, Diego G. Diel, Ben M. Hause, Feng Li, Dan Wang

Maxwell H. Gluck Equine Research Center Faculty Publications

Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease symptoms and virus replication in vaccine recipients exposed to PEDV challenge. Thus, these observations demonstrate a previously unrecognized challenge of PEDV vaccine research, which has important implications for coronavirus vaccine development.

Kentucky Annual Economic Report 2021, Michael W. Clark, James P. Ziliak, Simon Sheather

Kentucky Annual Economic Report

This report is one of the important ways that the Center for Business and Economic Research fulfills its mission to examine various aspects of Kentucky’s economy as directed by the Kentucky Revised Statutes (KRS 164.738). The analysis and data presented here cover a variety of topics that range from a discussion of Kentucky’s current economic climate to a broad presentation of factors affecting the economy.

The report covers numerous dimensions of Kentucky’s economy and COVID-19’s effects are evident across many of these dimensions. The pandemic brought the longest running economic expansion to an abrupt end. By April, Kentucky’s employment declined …

Investigation Of Equine In Vivo And In Vitro Derived Metabolites Of The Selective Androgen Receptor Modulator (Sarm) Acp-105 For Improved Doping Control, Malin Nilsson Broberg, Heather Knych, Ulf Bondesson, Curt Pettersson, Scott Stanley, Mario Thevis, Mikael Hedeland

Maxwell H. Gluck Equine Research Center Faculty Publications

Selective Androgen Receptor Modulators (SARMs) have anabolic properties but less adverse effects than anabolic androgenic steroids. They are prohibited in both equine and human sports and there have been several cases of SARMs findings reported over the last few years. The aim of this study was to investigate the metabolite profile of the SARM ACP-105 (2-chloro-4-[(3-endo)-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]oct-8-yl]-3-methylbenzonitrile) in order to find analytical targets for doping control. Oral administration of ACP-105 was performed in horses, where blood and urine samples were collected over a time period of 96 h. The in vivo samples were compared with five in vitro incubation models encompassing …

Macrophage-Derived Thrombospondin 1 Promotes Obesity-Associated Non-Alcoholic Fatty Liver Disease, Taesik Gwag, Raja Gopal Reddy Mooli, Dong Li, Sangderk Lee, Eun Young Lee, Shuxia Wang

Pharmacology and Nutritional Sciences Faculty Publications

Background

Thrombospondin 1 (TSP1) is a multifunctional matricellular protein. We previously showed that TSP1 has an important role in obesity-associated metabolic complications, including inflammation, insulin resistance, cardiovascular, and renal disease. However, its contribution to obesity-associated non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD or NASH) remains largely unknown; thus, we aimed to determine its role.

Methods

High-fat diet or AMLN (amylin liver NASH) diet-induced obese and insulin-resistant NAFLD/NASH mouse models were utilised, in addition to tissue-specific Tsp1-knockout mice, to determine the contribution of different cellular sources of obesity-induced TSP1 to NAFLD/NASH development.

Results

Liver TSP1 levels were increased in experimental obese …

Growth Characteristics And Productivity Of A New Cold‐Tolerant Italian Ryegrass (Lolium Multiflorum L.) Variety Kowinearly In Northern Part Of South Korea, Gi-Jun Choi, Young-Chul Lim, Byung-Ryul Sung, Ki‐Yong Kim, Jong-Kyung Lee, Keun-Bal Lim, Hyung-Soo Park, Sung Seo, Hee-Chung Ji

IGC Proceedings (1977-2023)

No abstract provided.