Digital Commons Network^™

A Comparison Of Devices For Race Day Characterization Of North American Turfgrass Thoroughbred Racing Surfaces, Peter Schmitt, Wayne T. Sanderson, John Trey Rogers Iii, Tyler J. Barzee, Michael L. Peterson

UK CARES Faculty Publications

Both pre-race meet and daily turf surface condition measurements are required by regula- tions adopted as part of the Horseracing Integrity and Safety Act (HISA). The Orono Biomechanical Surface Tester (OBST) is the primary device used for characterizing a racing surface and is used for the pre-meet inspections. Tools that are better suited for the daily testing of turf surfaces are also needed to meet the new federal regulations. The purpose of this study was to compare five simple tools commonly used in turf applications to the OBST. Data were collected with each of the six devices at plots chosen …

Early Emergency Department Experience With 7-Day Extended-Release Injectable Buprenorphine For Opioid Use Disorder., Gail D'Onofrio, Jeanmarie Perrone, Kathryn F. Hawk, Ethan Cowan, Ryan Mccormack, Edouard Coupet, Patricia H. Owens, Shara H. Martel, Kristen Huntley, Sharon L. Walsh, Michelle R. Lofwall, Andrew Herring, The Ed-Innovation Investigators

Center on Drug and Alcohol Research Faculty Publications

As the opioid overdose epidemic escalates, there is an urgent need for treatment innovations to address both patient and clinician barriers when initiating buprenorphine in the emergency department (ED). These include insurance status, logistical challenges such as the ability to fill a prescription and transportation, concerns regarding diversion, and availability of urgent referral sites. Extended-release buprenorphine (XR-BUP) preparations such as a new 7-day injectable could potentially solve some of these issues. We describe the pharmacokinetics of a new 7-day XR-BUP formulation and the feasibility of its use in the ED setting. We report our early experiences with this medication (investigational …

Deficiency Of Acute-Phase Serum Amyloid A Exacerbates Sepsis-Induced Mortality And Lung Injury In Mice, Ailing Ji, Andrea C. Trumbauer, Victoria P. Noffsinger, Luke W. Meredith, Brittany Dong, Qian Wang, Ling Guo, Xiangan Li, Frederick C. De Beer, Nancy R. Webb, Lisa R. Tannock, Marlene E. Starr, Christopher M. Waters, Preetha Shridas

Saha Cardiovascular Research Center Faculty Publications

Serum amyloid A (SAA) is a family of proteins, the plasma levels of which may increase >1000-fold in acute inflammatory states. We investigated the role of SAA in sepsis using mice deficient in all three acute-phase SAA isoforms (SAA-TKO). SAA deficiency significantly increased mortality rates in the three experimental sepsis mouse models: cecal ligation and puncture (CLP), cecal slurry (CS) injection, and lipopolysaccharide (LPS) treatments. SAA-TKO mice had exacerbated lung pathology compared to wild-type (WT) mice after CLP. A bulk RNA sequencing performed on lung tissues excised 24 h after CLP indicated significant enrichment in the expression of genes associated …

Ecohiv-Infected Mice Show No Signs Of Platelet Activation, Hammodah Rawhi Hammodah Alfar, Dominic Ngima Nthenge-Ngumbau, Kathryn E. Saatman, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Platelets express several surface receptors that could interact with different viruses. To understand the mechanisms of HIV-1′s interaction with platelets, we chose the EcoHIV model. While EcoHIV is an established model for neuroAIDS, its effects on platelets are ill-defined. Our results indicate that EcoHIV behaves differently from HIV-1 and is cleared from circulation after 48 h post- infection. The EcoHIV course of infection resembles an HIV-1 infection under the effects of combined antiretroviral therapy (cART) since infected mice stayed immunocompetent and the virus was readily detected in the spleen. EcoHIV-infected mice failed to become thrombocytopenic and showed no signs of …

Magnetic Resonance Imaging Of Macrophage Response To Radiation Therapy, Harrison Yang, Brock Howerton, Logan Brown, Tadahide Izumi, Dennis C. Cheek, Jason Anthony Brandon, Francesc Marti, Roberto Gedaly, Reuben Adatorwovor, Fanny Chapelin

Markey Cancer Center Faculty Publications

Background: Magnetic resonance imaging (MRI) is a non-invasive imaging modality which, in conjunction with biopsies, provide a qualitative assessment of tumor response to treatment. Intravenous injection of contrast agents such as fluorine (19F) nanoemulsions labels systemic macrophages, which can, then, be tracked in real time with MRI. This method can provide quantifiable insights into the behavior of tumor-associated macrophages (TAMs) in the tumor microenvironment and macrophage recruitment during therapy.

Methods: Female mice received mammary fat pad injections of murine breast or colon cancer cell lines. The mice then received an intravenous 19F nanoemulsion injection, followed by a baseline 19F MRI. …

Design And Characterization Of A Novel Eef2k Degrader With Potent Therapeutic Efficacy Against Triple-Negative Breast Cancer, Changxin Zhong, Rongfeng Zhu, Ting Jiang, Sheng Tian, Xiaobao Zhao, Xiaoya Wan, Shilong Jiang, Zonglin Chen, Rong Gong, Linhao He, Jin-Ming Yang, Na Ye, Yan Cheng

Markey Cancer Center Faculty Publications

Dysregulated eEF2K expression is implicated in the pathogenesis of many human cancers, including triple-negative breast cancer (TNBC), making it a plausible therapeutic target. However, specific eEF2K inhibitors with potent anti-cancer activity have not been available so far. Targeted protein degradation has emerged as a new strategy for drug discovery. In this study, a novel small molecule chemical is designed and synthesized, named as compound C1, which shows potent activity in degrading eEF2K. C1 selectively binds to F8, L10, R144, C146, E229, and Y236 of the eEF2K protein and promotes its proteasomal degradation by increasing the interaction between eEF2K and the …

Brachiaria Spp. (Syn. Urochloa Spp.) Cv. Mulato Ii (Convert Hd364) Mass Production Under Continuous Grazing In The Water/Dry Transition Period, A. L. A. Castro, A. C. Prado, M. C. Silva Júnior, M. S. Soares, M. V. Teixeira

IGC Proceedings (1977-2023)

In the transition period between the rainy and dry seasons there is decreased water, temperature and luminosity, reducing forage production and quality. Because of this variability in forage mass production, it is essential to quantify forage mass for use in planning and decision making about pastures management. The objective was to evaluate Brachiaria spp. (Syn. Urochloa spp.) cv. Mulato II (Convert HD364) growth, biomass production managed under continuous grazing with steers fed with protein supplement feed in-trough and on-ground during the seasonal transition period. The experiment was carried out in the Beef Cattle Sector of Jatai Federal University …

Production And Persistence Of Self-Regenerating Annual Clovers In The Pacific Northwest, Ian Silvernail, Serkan Ates

IGC Proceedings (1977-2023)

Self-regenerating annual legumes are commonly included in dryland pastures to increase the production of high-quality forages to meet the nutritional demands of growing and lactating animals. Balansa clover (Trifolium michelianum Savi), not as widely evaluated as subterranean clover (Trifolium subterraneum L.), has shown promise in Western Oregon. However, there is a paucity of information on the productivity and persistence of annual clover cultivars that have various flowering times. This study investigates the biomass production and persistence of early, mid and late flowering subterranean clover and balansa clover cultivars in Corvallis, Oregon. Averaged across the cultivars, the total annual …

Managing Vegetation In Grassland Habitats To Enhance Livestock Or Wildlife Objectives, B. B. Sleugh, S. Flynn, W. Hatler, C. Hart, S. Ingram, Joao B. Cason, D. Ovalle

IGC Proceedings (1977-2023)

Sustainably stewarding grassland systems involves applying various practices to manipulate forage interactions with other plants, the environment, and grazing animals to meet resource manager objectives. These interactions can result in invasion or encroachment and increased abundance of weeds which hinder attainment of management objectives. Weeds influence the structure and function of pasture ecosystems whether forages are grown in improved pastures, rangeland, or grassland communities. They degrade pasture quality and reduce livestock performance by interfering with forage establishment, yield, and quality by competing for resources. Weeds reduce the feed value of forage, decrease pasture carrying capacity, and can be toxic or …

Forage Allowance And Daily Gain Relationships On Rye-Ryegrass Pastures At Different Stocking Rates With Continuous And Rotational Stocking, F. M. Rouquette Jr., K. D. Norman, C. R. Long, E. Van Santen

IGC Proceedings (1977-2023)

‘Maton’ cereal rye (Secale cereale L.) and ‘TAM-90’ annual ryegrass (Lolium multiflorum Lam.) are used for winter annual pastures to background stocker cattle in the southeastern US. Rye and ryegrass were sod-seeded into bermudagrass [Cynodon dactylon (L.) Pers.] pastures and fixed-stocked at different rates under continuous and 8-paddock rotation methods during each of 7 years to: 1) compare stocking methods for daily gain per animal (ADG) and gain/ha; and 2) quantify relationships of ADG with forage mass and forage allowance. Each of 3 levels of stocking rate, 4.9, 6.4, and 8.6 hd/ha, significantly affected ADG at 1.24, …

Characteristics Of Lactic Acid Bacteria Strains Isolated From Tibetan Plateau And Their Effects On Silage Quality Of Italian Ryegrass (Lolium Multiflorum Lam.) At Low Temperature, Siran Wang, Mudasir Nazar, Niaz Ali Kaka

IGC Proceedings (1977-2023)

Temperature is an important factor affecting ensilage. In cold regions, low temperature could be an adverse environmental factor during ensiling. However, little research has focused on improving silage quality at low temperatures. This study aimed to examine two lactic acid bacteria (LAB) strains (LCG9 and TG1) isolated from the Tibetan Plateau, and evaluate their effects on the silage quality of Italian ryegrass (Lolium multiflorum Lam.) at three temperatures (10° C, 15° C and 25° C). The isolated strains and one commercial inoculant (G, Lactobacillus plantarum MTD-1) were evaluated by morphological, physiological and biochemical tests. Strains G, LCG9, TG1 and …

A Novel Tractor Operated Grass Seed Harvester Developed In India, Chandra Shekhar Sahay, D. S. Thorat, P. S. Pathak

IGC Proceedings (1977-2023)

The demand of green and dry fodder in India is estimated to increase to 1170 and 650 m tonne whereas availability is expected to be at 411.3 and 488 m tonne in 2025, respectively, depicting deficit of about 64.9% green fodder and 24.9% dry fodder (Vision 2030, ICAR - IGFRI, Jhansi, 2011). In forages, availability of quality seed is only 25-30% in cultivated fodder and less than 10 % in range grasses and legumes (Vision 2050, IGFRI). Prices paid for grass seeds of native species vary from Rs.5,000 to 6,500 per kg for clean, un-haired seeds due to excessive use …

Growth Components And Yield Of Brachiaria Ruziziensis (Congo Grass) And Centrosema Pascuorum (Centro) Mixtures As Influenced By Mixture Ratios, Phosphorus Levels And Stage Of Harvest, I. Sani, J. T. Amodu, R. J. Tanko, M. R. Hassan, N. Adamu

IGC Proceedings (1977-2023)

This study was conducted during the 2017 and 2018 rainy season at the Crop Production Research farm, Abubakar Tafawa Balewa University, Bauchi to determine the effects of plant mixture ratios in Brachiaria ruziziensis and Centrosema pascuorum (100% Sole B. ruziziensis, 75% B.R: 25% C.P, 50% B.R: 50% C.P, 25% B.R: 75% C.P and 100% Sole C. pascuorum) and phosphorus fertilizer (SSP) levels (0, 100 and 150kg/ha). The experiment was in a split-plot design with 5x3 factorial arrangement in which the mixture ratios constituted the main plots while phosphorus (SSP) levels constituted the sub treatments. Number of plants per …

Climate Change And Legume Performance In Grassland Agroecosystems, Lynn E. Sollenberger, M. M. Kohmann

IGC Proceedings (1977-2023)

We reviewed the literature to assess the effect of climate change factors on forage legumes. Whether growing in monoculture or mixtures with grasses, exposing legumes to elevated CO₂ (eCO₂) generally leads to sustained increases in forage accumulation (FA) and N fixation, but elevated temperature (eT) in conjunction with eCO₂ usually reduces magnitude of these responses. In legumes, nodules represent large C sinks, precluding photosynthetic acclimation to eCO₂ observed in non-N fixing plants. Greater N fixation in legume-grass mixtures exposed to eCO₂ is due to greater percentage of legume N derived from symbiotic fixation and …

Cattle Diet Composition Under A Short- Duration Grazing With And Without Deferment In Puna Rangelands, R. E. Tácuna, E. R. Flores

IGC Proceedings (1977-2023)

The treatments of rest and deferment periods have shown to be effective tools to improve range condition, but little is known about their effect on the diet of animals. The present research aimed to evaluate the effect of the deferment period when applied to a short-term grazing system. The experimental design was a completely random factorial where the treatments resulted from combination of two grazing management systems: short-duration with deferment period (WD) and no deferral period (ND) both evaluated for three years. Forage yield (4.9 vs. 4.5 Tm DM ha^-1 year^-1) like range condition (55.5 vs. 50.7%) …

Canopy Changes Of Brachiaria Managed Under Continuous Stocking In The Dry-Water Transition, M. R. Castro, A. L. Bocchi, V. L. Banys, A. L. A. Castro, E. A. Collao-Sanez

IGC Proceedings (1977-2023)

Pasture supplementation is an alternative to take advantage of the forage mass deferred in the rainy season and maintain or provide weight gain in periods of rain absence. The objective was to compare the structural characteristics, mass production, density and population dynamics of tillers of Urochloa brizantha cv. ‘Paiaguas’ and U. spp. cv. ‘Convert’ under fixed and continuous stocking with steers supplemented in the trough or on the ground in the water/dry transition period. The experiment was carried out at Jatai Federal University, from March to June, in a completely randomized design and a 2x2 factorial scheme, using six …

Canopy Changes Of Brachiaria Managed Under Continuous Stocking In The Dry-Water Transition, M. T. Maciel, A. L. Bocchi, V. L. Banys, A. L. A. Castro, E. A. Collao-Sanez

IGC Proceedings (1977-2023)

Pasture supplementation is an alternative to take advantage of the forage mass deferred in the rainy season and maintain or provide weight gain in periods of rain absence. The objective was to compare the structural characteristics, mass production, density and population demography of tillers of Urochloa brizantha cv. Paiaguás and Urochloa spp. cv. Convert under fixed and continuous stocking with steers supplemented with pelleted concentrate supplied in the trough or on the ground in the water/dry transition period. The experiment was carried out in the Jatai Federal University, from March to June 2020, in a completely randomized design and …

Cool-Season Perennials And Stability In Year-Round Forage Production Systems, C. D. Teutsch

IGC Proceedings (1977-2023)

Changes in long-term climate normals have resulted in warmer and wetter summers and milder winters in the humid eastern United States. This will likely impact regional forage species adaptation in the long-term and varietal adaptation in the short term. Variety evaluation has been occurring at the University of Kentucky for almost 100 years. There are several considerations for selecting forage species and varieties including regional and local adaptation, productivity, distribution of growth, palatability, nutritive value, anti-quality factors, tolerance to stress, and persistence. Two of the most important criteria are long-term productivity and persistence under grazing, both of which are currently …

Spectral Reflectance Indices Associated With Biomass Production Of Cold Stress Resistant White Clover Genotypes Collected In Argentine And Chilean Patagonia, Hernán Acuña, Luis Inostroza, Catalina Vásquez, Joel Ibañez

IGC Proceedings (1977-2023)

White clover (Trifolium repens L.) is the main forage legume species in grazing pastures in central and southern Chile and many other temperate regions of the world. Its growth rate is limited by low temperature, therefore, the selection of cold stress resistant genotypes is an important step for breeding cultivar to improve the clover growth curve and extend the grazing season in early spring and autumn. The main objective of this experiment was to determine the relationship between phenotypic traits, measured by the high-throughput phenotyping procedures based on canopy reflectance at different wavelengths (spectral reflectance indices, SRIs), and dry …

Stocking Rates And Carrying Capacity Of Grazing Lands In Bale Mountain National Park And Adjacent Areas, Southeast Ethiopia, Mohammed Abdulahi, Habtamu Teka, Hadis Tadele

IGC Proceedings (1977-2023)

Knowledge of grazing land carrying capacity and grazing pressure in and around protected areas is very crucial to support decision making over sustainable grazing levels and developing grazing pressure reduction strategies. However, there was lack of studies conducted on livestock carrying capacity and grazing pressure in the connected and dynamic system over a wider landscape scale. Hence, this study was conducted to estimate the livestock stocking rates and carrying capacity of grazing lands in Bale Mountain National Park (BMNP) and adjacent districts grazing lands, southeast Ethiopia. Three categories of data: Field surveys, satellite imagery, and socioeconomic secondary data were used. …

Grazing Effects On Soil Seed Banks: A Global Synthesis, Shi Yafei

IGC Proceedings (1977-2023)

Livestock grazing is a major disturbance affecting plant diversity and abundance in terrestrial ecosystems. The intermediate disturbance hypothesis (IDH) predicts that moderate-intensity grazing should produce the highest species diversity, while the Milchunas-Sala-Lauenroth (MSL) model posits that the IDH is valid only for mesic areas. However, it remains unclear how grazing affects soil seed bank and whether or not the IDH or MSL models are valid for soil seed bank communities. Here, we presented a global meta-analysis synthesizing 483 observations: we found that grazing had a negative effect on soil seed bank abundance, but did not alter seed bank richness. Further …

Effects Of Warming And Nitrogen Addition On Soil Enzyme Activities, X. Zhang, G. D. Han

IGC Proceedings (1977-2023)

Due to the intensification of human activities, global warming and increased atmospheric nitrogen deposition have become important driving factors of global change. In order to understand the effects of long-term warming and nitrogen application on soil physical and chemical properties and enzyme activities, the effects of warming and nitrogen application on grassland soil enzyme activities were measured. The aim was to reveal the response of enzyme activity in an Inner Mongolian desert steppe to long-term warming and nitrogen addition. The results were as follows. In 2018, nitrogen fertilization significantly increased soil dehydrogenase activity, and soil depth significantly affected soil urease, …

Additive Negative Effects Of Decadal Warming And Nitrogen Addition On Grassland Community Stability, Q. Wu, G. D. Han, S. X. Chang, H. Y. Ren

IGC Proceedings (1977-2023)

Much recent research has explored how global warming and increased nitrogen (N) deposition, two important components of global environmental changes, influence the structure and functioning of natural ecosystems. However, how ecosystem dynamics respond to the combination of long-term warming and N enrichment remains largely unexplored. The impact of warming and N addition on the temporal stability of plant communities were investigated in a decade-long field experiment. The study was conducted in northern China in a desert steppe, using a split-plot design with warming as the main-plot factor and N addition as the splitplot factor. Long-term warming and N addition had …

Grass-Next – A Process-Based Model To Explore Nutrient And Carbon Dynamics In Topographically Complex Grazed Grasslands, F. Bilotto, Ronaldo Vibart, Alec D. Mackay, M. Harrison

IGC Proceedings (1977-2023)

Topographical features such as slope and aspect influence primary production, animal behavior and nutrient return to grazed grasslands. A new model was developed based on data collected during 40+ years of research in hill country landscapes, a long-term experiment on varying phosphorus (P) fertilizer rates and associated sheep stocking regimes. The Grass-NEXT model was able to simultaneously simulate total soil P (TSP), soil organic carbon (SOC) and total soil nitrogen (TSN) stock change and distribution in a topographically complex (hill country) landscape from 2003 to 2020. This model provided a basis for exploring, accounting, and reporting on changes in TSP, …

Discrepancies Between Observed And Predicted Climate-Driven Net Herbage Accumulation, Alec D. Mackay, Michael B. Dodd, K. J. Hutchinson, Ronaldo Vibart, F. Bilotto

IGC Proceedings (1977-2023)

The decline in net herbage accumulation (NHA) on the high phosphorus (P) fertilizer farmlet (HF) of a long-term P fertilizer and associated sheep grazing experiment in the last 25 years, aligns with the necessity to reduce the on-site nominal sheep stocking rates over the same period on this farmlet. This finding appears at odds with projected climate change driven modelling that forecast a largely positive outcome on pasture growth in summer moist environments. In this paper we explore the apparent discrepancies between the observed and predicted climate-driven NHA by using a climate-driven pasture growth module within a larger process-based model …

Beyond The Boom: Integrated Approaches To Managing Weeds And Brush, M. L. Treadwell, D. Burson

IGC Proceedings (1977-2023)

William Bray stated in his 1904 report, The Timber of the Edwards Plateau of Texas, "This struggle of the timberlands to capture the grasslands is an old warfare....it spreads like infection.” This trend is true today and especially pronounced in the Great Plains, where only 1/4 of the Great Plains’ original grasslands remains intact. Species like honey mesquite, honey locust, black locust, sumac, dogwood, post oak, winged elm, Siberian elm, salt cedar, huisache, Eastern redcedar, Ashe and redberry juniper, pricklypear, sericea lespedeza, and many other species represent alarming rates of spread and rapid establishment throughout Great Plains grasslands. Although, these …

Impact Of Brown Midrib Trait On The Decomposition Rate Of Sorghum-Sudangrass Residue In Pastures, C. D. Teutsch, B. P. Dooley, J. A. Bush, B. L. Hendrix

IGC Proceedings (1977-2023)

Sorghum-sudangrass (Sorghum bicolor var. bicolor x bicolor var. sudanense) can provide high quality summer grazing. Some varieties possess the brown midrib (BMR) trait which results in reduced lignin resulting in higher digestibility and animal performance. If microbes in the rumen can digest BMR sorghum-sudangrass more completely, then soil macro/micro flora and fauna may do so as well. This could result in nutrients being returned to the soil faster from plants containing the BMR trait. The objective of this study was to determine the decomposition rate of BMR and non-BMR sorghumsudangrass. The experimental design was a random complete with four …

Back To The Future: How Do We Get There From Here? Making Restoration Work, K. Swilling, E. Bisangwa, Pat D. Keyser

IGC Proceedings (1977-2023)

Extreme temperatures and long periods of drought observed with increasing frequency in the southeastern United States (U.S.) have demonstrated the need to develop more robust forage systems. Native warmseason grasses (NWSGs) are well adapted to fill this role, but their expanded use comes with several challenges, most notably, reliable establishment. The high cost of site preparation, high cost of seed, and slow initial growth of NWSG seedlings must be addressed to achieve increased adoption of NWSG in the eastern U.S. If these challenges are overcome, incorporating NWSG into grazing systems would benefit producers by filling the summer forage gap, mitigating …

Challenges And Opportunities To Increase Carbon Sequestration In Subtropical Grazing Lands, Maria L. S. Silveira, João M. B. Vendramini, Elizabeth H. Boughton, Rosvel Bracho, Marta M. Kohmann, Abmael S. Cardoso

IGC Proceedings (1977-2023)

Livestock production has a significant environmental footprint. However, adoption of regenerative grazing land management practices can serve as a means of producing food with lower, or even net positive environmental impacts. Globally, much of the grazing land ecosystems are degraded due to improper management. This is particularly true in the southeastern US, where extensive areas of planted pastures are degraded due to inadequate nutrient and soil management. In this presentation, we will discuss the opportunities and challenges associated with increasing soil and ecosystem C sequestration in subtropical grazing lands through regenerative management practices. Introduction

Impact Of The Brachiaria Hybrids On Both Soil Health And Carbon Stock On Livestock Production, A. Silva, T. Madeira, D. Florian, E. A. Pizarro, R. N. Jauregui, G. Lobato, A. Santi, D. Fagundes, F. Pinheiro, A. Rieger, A. Cagliari

IGC Proceedings (1977-2023)

Pastures occupy 30% of Earth and 80% of the entire agricultural area of the planet. To ensure food to the world and contribute to the quality of the environment, pasture-based animal production systems will also have to undergo through a more intense evolution. The intensification of tropical grasslands is an important strategy of land utilization in developing countries, contributing to increase production and minimize environmental impact through the best management practices. In this sense, the use of Brachiaria hybrids represents an excellent option, since combining the best traits of different Brachiaria species, with higher nutritive value, forage, and seed yield. …