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Indirect Causation: A Reminder From The Biblical Goring Ox Rule For Fraud On The Market Securities Litigation, Andrew R. Simmonds

Kentucky Law Journal

No abstract provided.

Reporting On Child Pornography: A First Amendment Defense For Viewing Illegal Images?, Clay Calvert, Kelly Lyon

Kentucky Law Journal

No abstract provided.

Post-Transcriptional Regulation Of Mammalian Heat Shock Factors, Michael L. Goodson

University of Kentucky Doctoral Dissertations

Heat shock transcription factors (HSFs) function to regulate the expression of heatshock proteins (hsps) or molecular chaperones in the cell. Mammalian cells have twowell-characterized HSFs, HSF1 and HSF2. HSF1 functions to regulate the stress-inducedexpression of hsps. The function of HSF2 appears to be in regulating hsp expressionduring development and differentiation.In this work, I describe two distinct HSF1 mRNA isoforms (HSF1-a and HSF1-b)that are generated by alternative splicing of the HSF1 pre-mRNA. The two HSF1 mRNAisoforms result from the inclusion (HSF1-a), or omission (HSF1-b), of a 66 nucleotideexon of the HSF1 gene, which encodes a 22 amino acid sequence. These results …

Ovipositional Behavior Of The 12-Spotted Lady Beetle, Coleomegilla Maculata: Choices Among Plant Species And Potential Factors Influencing Those Choices, Marisa Lynn Griffin

University of Kentucky Master's Theses

Coleomegilla maculata is a beneficial coccinellid commonly found in sweet cornfields in Kentucky. Previous work on C. maculata has shown an ovipositional preferencefor the weed Acalypha ostryaefolia, compared to three selected weed species and corn. Also, predation of C. maculata egg clusters on A. ostryaefolia was less compared toclusters on corn and the presence of A. ostryaefolia led to higher densities of C. maculata larvae on corn.

I determined C. maculata ovipositional preference among weed species in fieldtests using nine common weeds. I also examined ovipositional preference using just A.ostryaefolia and Abutilon theophrasti. I assessed the roles of …

Implantable Controlled Release Device To Deliver Drugs Directly To An Internal Portion Of The Body, Paul Ashton, Paul A. Pearson

Ophthalmology and Visual Science Faculty Patents

A simple and implantable sustained release drug delivery device with an inner core containing an effective amount of a low solubility agent covered by a non-bioerodible polymer coating layer that is permeable to the low solubility agent is disclosed. A method for treating a mammal to obtain a desired local or systemic physiological or pharmacological effect by surgically implanting such a sustained release drug delivery device into a mammal in need of treatment is also disclosed.

Spin Trapping Pharmaceutical Compositions And Methods For Use Thereof, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Other preferred spin-trapping agents include 5,5-dimethyl pyrroline N-oxide, (DMPO), α-(4-pyridyl-1-oxide)-N-tert-butylnitrone, (POBN), and (TEMPO) spin-trapping derivatives thereof. …

Elicitin-Mediated Plant Resistance, Joseph Chappell, Shaohui Yin, Catherine Cornett

Pharmaceutical Sciences Faculty Patents

Qualitative transcriptional regulatory sequences functional in plants, plant tissue and in plant cells for inducible gene expression and quantitative transcriptional regulatory sequences for increasing the transcriptional expression of downstream genetic information in plants, plant tissue and plant cells are disclosed. Also disclosed are methods and recombinant DNA molecules for improving the disease resistance of transgenic plants, especially wherein an inducible promoter controls the expression of a protein capable of evoking the hypersensitive response in a plant.

Forage News [1999-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Forages at Farm Bureau
• Forages at KCA
• 20^TH Kentucky Alfalfa Conference
• How’s Your Hay Supply? Quality?
• KFGC President’s Corner
• KFGC Award Winners Announced
• Eden Shale Early Weaning Experiment
• Kentucky Hay
• Upcoming Events

Light Backscatter Of Milk Products For Transition Sensing Using Optical Fibers, Frederick A. Payne, Czarena L. Crofcheck, Sue E. Nokes, Klat C. Kang

Biosystems and Agricultural Engineering Faculty Publications

Transition sensors are needed, particularly in the dairy industry, for detecting transitions in pipe flow systems from product-to-water or product-to-product (such as from chocolate to vanilla ice cream mix). Transition information is used to automatically sequence valves to minimize product waste. Optical fibers were used to measure light backscatter between 400 and 950 nm as a function of milk concentration in water and milkfat concentration in milk. The normalized response (100% for product and 0% for water) as a function of product concentration in water was approximately logarithmic for skim milk between 400 and 900 nm and approximately linear for …

Forage News [1999-10], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Dealing with the Drought of ’99 Fall Forage Conference is October 5
• What to Do with Thin, Open, Cull Cows Has Always Been a Question for Beef Producers
• Princeton Grazing School Set For October 12-14
• Kentucky Forage & Grassland Council Activities
• Evaluating Hay Quality
• Upcoming Events

Forage News [1999-09], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Fertilizing Drought-Stressed Forages
• Harvesting Soybeans for Hay: What Kind of Hay Does it Make? Yield? Problems?
• New Round Bale Hay Storage at Eden Shale
• Nitrates in Forages
• Fall Grazing School
• What About Drilling Small Grain Into Dormant Pastures?
• KFGC Accepting Nominations
• Upcoming Events

Insulin-Like Growth Factor Ii Signaling In Neoplastic Proliferation Is Blocked By Transgenic Expression Of The Metalloproteinase Inhibitor Timp-1, David C. Martin, John L. Fowlkes, Bojana Babic, Rama Khokha

Pediatrics Faculty Publications

Insulin-like growth factor (IGF) II is overexpressed in many human cancers and is reactivated by, and crucial for viral oncogene (SV40 T antigen, [TAg])-induced tumorigenesis in several tumor models. Using a double transgenic murine hepatic tumor model, we demonstrate that tissue inhibitor of metalloproteinase 1 (TIMP-1) blocks liver hyperplasia during tumor development, despite TAg-mediated reactivation of IGF-II. Because the activity of IGFs is controlled by IGF-binding proteins (IGFBPs), we investigated whether TIMP-1 overexpression altered the IGFBP status in the transgenic liver. Ligand blotting showed that IGFBP-3 protein levels were increased in TIMP-1-overexpressing double transgenic littermates, whereas IGFBP-3 mRNA levels were …

Method Of Protecting Against Neuron Loss, Philip W. Landfield

Pharmacology and Nutritional Sciences Faculty Patents

The present invention pertains to a method of protecting against neuron loss in a subject by administering a compound that protects against neuron loss by acting through a vitamin D receptor. Some of these compounds may prevent or retard neuron loss by regulating intraneuronal and/or peripheral calcium and phosphate levels. Other compounds of the invention act through a vitamin D receptor to protect against neuron loss through mechanisms not involving calcium or phosphate regulation. A preferred compound is a biologically active form of vitamin D, a precursor, metabolite, or analog of vitamin D. A preferred form of vitamin D is …

Forage News [1999-08], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Choose Varieties Wisely
• Economics of Baled Silage
• Stockpiling Begins in August
• Do Domestic Animals Have Minds and the Ability to Think? A Provisional Sample of Opinions on the Question
• AFGC Leadership Conference
• Upcoming Events

The Hidden Work Of The Farm Homemaker, Deborah B. Reed, Susan C. Westneat, Steven R. Browning, Lana Skarke

Preventive Medicine and Environmental Health Faculty Publications

Despite women’s involvement in agricultural production, the work role of women residing in farm households has not been thoroughly examined. Data collected in 1994-1995 as part of the NIOSH-sponsored Farm Family Health and Hazard Surveillance Project were used to address task issues and health status of farm women in Kentucky. In 1996, the farm woman component of the Kentucky study was replicated in five counties in west Texas, allowing an examination of farm women in two large agricultural states. The Kentucky study employed a two-stage cluster design;the Texas study was based on a systematic quota sample of farms. Both studies …

Conversion Of New Circle Road To A Limited Access Highway, Steven M. Henderson, Nikiforos Stamatiadis

Kentucky Transportation Center Research Report

The objectives of this study were to first evaluate the existing traffic conditions along the NE part of New Circle Road and investigate the use of unconventional left turn treatments, as well as other access restrictions to improve the operating conditions of New Circle Road. The alternatives examined include a do-nothing alternative, the addition of one through lane per direction, the use of median U-turns at various locations, and combinations of them. Restrictive left turn strategies proved to be a more successful tool for traffic management on New Circle Road than simply adding a lane in each direction. Using median …

Laser Skin Graft Harvesting Apparatus And Related Method, David S. Kirn

Surgery Faculty Patents

A laser dermatome is disclosed for harvesting and meshing grafts of skin. A roller driven by a motor lifts the leading edge of a portion of skin for cutting by a beam of light generated by a laser. Adhesive tape attached to the roller aids in lifting the portion of skin and is further utilized to secure the severed portion of skin to the roller. A stage mounted atop an axle supports the laser or a beam director. The movement of the stage is controlled by second and third motors which drive the stage along or rotate it about the …

Methods Of Treating Eye Conditions With Human Leukocyte Elastase (Hle) Inhibitory Agents, George A. Digenis, Charles Khouri

Pharmaceutical Sciences Faculty Patents

A method of reducing corneal scarring or fibroblast proliferation comprises applying to an area of a subject's eye afflicted with the condition a corneal scar-fibroblast proliferation-reducing amount of a free or polymer-bound HLE inhibitory agent under conditions and for a period of time effective to attain the desired effect. A method of reducing neovascularization of corneal scar tissue comprises applying to an area of a subject's eye afflicted with the condition a neovascularization-inhibitory amount of a free or polymer-bound HLE inhibitory agent under conditions and for a period of time effective to attain the desired effect.

Predicting The Cutting Time Of Cottage Cheese Using Backscatter Measurements, Czarena L. Crofcheck, Frederick A. Payne, Sue E. Nokes

Biosystems and Agricultural Engineering Faculty Publications

An automated system for monitoring culture growth and determining coagulum cutting time is needed for cottage cheese manufacturing. A light backscatter measurement system was designed and installed in a local cottage cheese manufacturing plant. A cutting time prediction algorithm was developed using parameters generated from the backscatter profile. The cutting time prediction algorithm, T_cut = T_max + β₂ S, used two time-based parameters generated from the backscatter profile (T_max and S) and one operator selected parameter, β₂, to predict the coagulum cutting time, Tcut. The standard error of prediction for the algorithm was 6.4 …

Forage News [1999-06], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Forage/Beef Field Day - Crittenden County - June 15
• Forage Field Day Stops Show the Best of UK
• University of Kentucky’s Eden Shale Research Farm
• Testing Hay is the Best Deal in Town
• Spring Grazing Schools Went Well
• Fenceless Grazing
• Preliminary Investigations of Grazing Horses on Alfalfa
• Upcoming Events

Isolated Spinach Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase Large Subunit ΕN-Methyltransferase And Method Of Inactivating Ribulose-1,5-Bisphosphatase Carboxylase/Oxygenase Large Subunit ΕN-Methyltransferase Activity, Robert L. Houtz

Horticulture Faculty Patents

The gene sequence for ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) large subunit (LS) .sup.ε N-methyltransferase (protein methylase III or Rubisco LSMT) from a plant which has a des(methyl) lysyl residue in the LS is disclosed. In addition, the full-length cDNA clones for Rubisco LSMT are disclosed. Transgenic plants and methods of producing same which have the Rubisco LSMT gene inserted into the DNA are also provided. Further, methods of inactivating the enzymatic activity of Rubisco LSMT are also disclosed.

Forage News [1999-05], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• By-Product Feeds for Postweaning Feeding of Calves
• High Levels of Hard Seed Present in Annual Lespedeza
• Grazing Tolerance Publications Available on the Web
• Kentucky Forage & Grassland Council - President’s Corner
• Layout and Design
• Seeding Rate of Different Alfalfa Seed Lots
• What’s New in Autotoxicity?
• Upcoming Events

(Re)-Defining Scottish Nationalism After Devolution. Disclosure Interviews Cairns Craig, Lisa Stein, Amy Wright

disClosure: A Journal of Social Theory

No abstract provided.

The Probabilities Of Sinking For Kerry Coons, Peter Neufeld

disClosure: A Journal of Social Theory

No abstract provided.

Forage News [1999-04], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Alfalfa Conference to Celebrate 20^TH Anniversary
• Correct Web Address for Variety Testing Publications
• Spring Into Kentucky Grazing Schools
• Kentucky Forage & Grassland Council President’s – Corner
• Lime Coating Affects
• How Many Alfalfa Plants Are Needed?
• Pasture Aeration Tools
• Fence and Water Systems for Management-Intensive Grazing
• Upcoming Events

Formulations And Methods To Treat And Prevent Equine Protozoal Myeloencephalitis, David E. Granstrom, Thomas Tobin

Veterinary Science Faculty Patents

The present invention provides formulations useful to treat EPM. It also provides methods to treat EPM in a horse in need of such treatment, comprising administering a pharmaceutically effective amount of a triazine-based anti-coccidial. Preferred are methods to treat EPM using clazuril, diclazuril, toltrazuril or letrazuril. The present invention also provides methods to prevent S. neurona infection in horses comprising administering a prophylactic amount of a triazine-based anticoccidial. Preferred is a method to prevent S. neurona infection by using clazuril, diclazuril, toltrazuril or letrazuril, alone or in combination with other known therapeutics.

Forage News [1999-03], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Commissioner of Agriculture to Address Alfalfa Conference
• Jeffries New AFGC President
• Ken Johnson Elected to AFGC Board
• Grazing Data Summarized
• Economic Optimum Stocking Rates: Some Alternative Perspectives
• Quality Characteristics of Eastern Gamagrass Forages
• Harvesting Quality Hay: What the Research Shows
• Upcoming Events

15th Annual Environmental Law Institute, Office Of Continuing Legal Education At The University Of Kentucky College Of Law, W. Blaine Early Iii, Timothy J. Hagerty, E. Allen Kyle, Lee Colten, Tom C. Van Arsdall, John R. Leathers, Clinton J. Elliott, Thomas J. Fitzgerald, Jeffrey M. Sanders, Richard H. Underwood, Bradley E. Diillon, Henry L. Stephens, Lauren Anderson, David A. Smart

Continuing Legal Education Materials

Materials from the 15th Annual Environmental Law Institute held by UK/CLE in March 1999.

Marketing Alfalfa Hay: What The Consumer Demands, Tom Keene

Kentucky Alfalfa and Stored Forage Conference

Anytime we address selling a product to the consumer; our first objective should always be to sell a quality product. However before we get into quality, I think we need to back up and understand that quality can vary from customer to customer depending upon the type of livestock he is feeding. For instance, if you are selling hay to a dairy operation, how is the hay being utilized? Is it being fed free choice? Is it going into a milking TMR (total mixed ration)? Is it going to feed young stock, breeding heifers, or sick animals? Each group of …

How I Produce And Market Alfalfa Hay, John Nowak

Kentucky Alfalfa and Stored Forage Conference

John Nowak was born March 22, 1947, in New York City and was raised in Westchester County, just north of New York City. After graduating from Colorado State University with a B.S. degree in farm and ranch management, he entered the U.S. Army. John served on active duty from 1969 until 1978. In 1975, his Army career brought him to Fort Campbell, Kentucky, and he began farming part-time in Christian County in 1976. As with many "start-from-scratch" farmers, John's first farming efforts involved producing burley tobacco during the years 1976 through 1979. In 1979, he began a cow-calf and backgrounding …