Digital Commons Network^™

The Effect Of Using Crispr/Cas9 Treatment To Delete The Myostatin Protein In Vivo And In Vitro, Marco Cardone

Honors Undergraduate Theses

This thesis proposal shows the efficiency of different methods of Myostatin inhibition by using CRISPR/CAS9. With the data cataloged by this thesis, researchers will have a better understanding of what methods are better to achieve their goals. The data was collected by reading multiple scientific articles involving the usage of CRISPR/CAS9 to inhibit the Myostatin protein. The data collected from all the different studies were analyzed in the same categories. The experiment that used CRIPSR/CAS9 on in vitro specimens had a superior Myostatin inhibition overall, therefore presenting higher muscle mass. The method using CRISPR/CAS9 to inhibit the Myostatin in vivo …

Algebraic And Combinatorial Approaches For Counting Cycles Arising In Population Biology, Brian Chau

Honors Undergraduate Theses

Within population biology, models are often analyzed for the net reproduction number or other generalized target reproduction numbers, which describe the growth or decline of the population based on specific mechanisms. This is useful in determining the strength and efficiency of control measures for inhibiting or enhancing population growth. The literature contains many algebraic and combinatorial approaches for deriving the net reproduction number and generalized target reproduction numbers from digraphs and associated matrices. Finding, categorizing, and counting the permutations of disjoint cycles, or cycles unions is a requirement of the Cycle Union approach by Lewis et al. (2019). These cycles …

Experiences Of Limited English Proficiency (Lep) Patients In Healthcare, Javier Cintron

Honors Undergraduate Theses

As the US becomes increasingly more diverse, the presence of non-English speaking individuals also increases. With healthcare being a vital aspect of most individuals’ lives, it is drastically affected by any gap in communication, especially when a language barrier is present. For this investigation, I conducted a research study to examine the experiences of limited English proficiency (LEP) patients in healthcare using anthropological methods. The aim was to understand how having LEP affects patients. The primary form of data collection for this project consisted of Semi-structured interviews with a sample of individuals with LEP. In addition to interviews, I analyzed …

Cerium Oxide Nanoparticles And Beneficial Bacteria: Two Novel Treatments For Eradicating Bacteria Associated With Prosthetic Infection?, Etta Conteh

Honors Undergraduate Theses

The purpose of this thesis was to investigate new possible compounds that can be used to treat orthopedic implant infections caused by bacterial pathogens. Current treatment includes the use of antibiotics and the DAIR procedure, which stands for debridement, antibiotic therapy, irrigation, and retention. However, antibiotics are becoming less effective as a treatment due to bacteria gaining antibiotic resistance. Two bacterial species involved in orthopedic implant infections are P. aeruginosa and S. aureus. This thesis investigated cerium oxide nanoparticles and L. fermentum, a beneficial bacterium, as possible treatments to stop bacterial growth and the formation of biofilm. This …

Polarization Dependence Of High Order Harmonic Generation From Solids In Reflection And Transmission Geometries, Erin L. Crites

Honors Undergraduate Theses

High harmonic generation (HHG) is a process that occurs when an intense laser interacts with a material and generates new frequencies of light. HHG has many practical applications, namely as a spectroscopy technique and source for high frequency light and attosecond pulses. While HHG has been done extensively in gases, HHG in solids is a relatively new field. Solids are appealing as an HHG medium as they require much simpler equipment and are subsequently much more compact, and thus may have a variety of applications previously inaccessible to gas-phase HHG. However, the generation mechanism of HHG in solids has not …

Exploring The Different Factors Associated With Burnout, Natassja J. Debra

Honors Undergraduate Theses

Maslach and Leiter determined burnout to be caused by three major components: exhaustion, cynicism, and inefficiency. This literature review focuses on factors that directly contribute to new graduate nurse burnout. Major factors discussed in this paper are differences in expectations versus reality, influences from past education, developing professional identity, and the effect of the workplace environment on new graduate transition. Interventions to combat burnout are discussed along with recommendations for future research.

Corruption And Anti-Corruption Agencies: Assessing Peruvian Agencies' Effectiveness, Kia R. Del Solar

Honors Undergraduate Theses

Corruption has gained attention around the world as a prominent issue. This is because corruption has greatly affected several countries. Following the exploration of various definitions and types of corruption, this thesis focuses on two efforts to rein in “grand corruption”, also known as executive corruption. The thesis is informed by existing theories of corruption as well as anti-corruption agencies and then situates Peru’s experience with corruption in its theoretical context and its broader Latin American context. This work conducts a comparative analysis and follows a process-tracing approach to examine and evaluate Peru’s recent anti-corruption agencies and their effectiveness in …

The Lasting Legacy Of Chemical Weapons In Iraqi Kurdistan, Jenna L. Dovydaitis

Honors Undergraduate Theses

In 1988, the Iraqi regime executed the Anfal Genocide against its Kurdish population, killing a conservative estimate of approximately 50,000 to 100,000 Kurds (Human Rights Watch, 1993). This genocide involved the widespread usage of chemical weapons and marked a highly traumatic moment in modern Kurdish history. As of today, little academic research has been completed on the long-term medical and political consequences of exposure to chemical weapons in the Kurdistan region.

This exploratory research aims to contribute to the body of literature on this topic through interviews with medical professionals, Kurdish politicians, and non-governmental organization employees that have expertise on …

Detection Of A Peptide Hormone - Somatostatin - Label-Free Split-Aptameric Probes, Charles A. Dowis

Honors Undergraduate Theses

Peptide hormones are important biomolecules that transduce downstream effects such as cell proliferation, regulation, and gene expression. Their levels have been upregulated in various disorders such as cancer, yet detection methods are lacking. We designed two split aptamer-based assays for the detection of a peptide hormone – Somatostatin (SST) – with different signal readouts: fluorescent readout based on light-up aptamers and the colorimetric readout of ABTS peroxidation from a G-quadruplex. We used an already selected split-aptamer –SSTA5–for SST for our designs and we had expected the developed detection systems to exhibit detection and quantification capabilities that would hopefully allow their …

Middle Eastern And Western Leaders Speeches On Counterterrorism, Ranya Eid

Honors Undergraduate Theses

This research analyzes political leaders' response to the ideological challenge presented by ISIS and Al Qaeda. It focuses on the counterterrorism speeches given by political leaders in a number of Middle Eastern countries and the United States. The analysis of the speeches is along two dimensions: the nature of their domestic and international audiences, and the motivations behind the speeches. A sample of several dozens of speeches is analyzed. The empirical study had proved that leaders mostly exhibit differences depending on their audiences to reach a certain political goal. While leaders tend to call for unification among countries in their …

Using Cellphones To Advance Diabetic Foot Care Practice: A Review Of The Literature, Qiuna Fang

Honors Undergraduate Theses

Preventing diabetic foot ulcers among patients diagnosed with diabetes is an important element of care as diabetic foot ulcers present major medical, psychosocial and economic threats. In addition, about 20% of the diabetic foot ulcer cases will ultimately require amputation and cause greater mortality rates. The purpose of this literature review was to evaluate cellphone use to promote diabetic foot care practices among patients with diabetes. Six electronic databases were searched for articles which included text messaging and or phone interventions geared at improving foot care practices. A total of 14 articles dated 2009-2019 met the inclusion criteria and were …

The Effects Of Sleep Deprivation On Mental Health And Neurological Disorders, Gabriella Victoria Fernandez De Salvo

Honors Undergraduate Theses

Sleep deprivation is defined as an individual sleeping less than 6 hours per night. It is a common behavior amongst individuals who live in industrialized nations.Along with industrialization, its prevalence is also expected to rise with age. Despite this, there has been a shift in recent years with sleep deprivation increasing in the youth, likely related to the increased use of technology during the nighttime. Sleep deprivation and chronic sleep disruption are behaviors commonly observed amongst patients suffering from neurological and psychiatric disorders, like Alzheimer’s disease, Parkinson’s disease, depression, and anxiety. Many of these patients suffer from sleep disorders like …

Evaluating The Nutritional Status Of Peruvian Born Children, Chantelle Garcia Medina

Honors Undergraduate Theses

Background: Rural areas of Peru lack access to healthcare resources and poor nutritional knowledge of what should be given to their children throughout their growth and development. The majority of the rural areas rely on a high carbohydrate, moderate vegetable diet, and lacking a protein source. Lower protein intake can lead to problems of malnutrition and growth stunting. Families rarely have monetary resources to provide a protein at every meal for the entire family. There is also a lack of a clean water supply, free of parasites and helminths. Caregivers often rely on replenishing intake with other fluids high …

Performance In Vr, Gabriela N. Gonzalez

Honors Undergraduate Theses

Psychologists once believed that memory was the result of a single-unitary memory system, and that memory was representative of a video recording. However, recent research has found that memory is malleable, and different factors can attribute to the accuracy of memory. Factors include internal bias, time since event, level of rehearsal, and outside influences. Specifically, the concept of false memories in regards to eyewitness testimony has garnered the attention of researchers. Prior research regarding false memories has looked at the impact of leading questions on memory accuracy. This study aims to explore the impact of leading questions on false memories …

Restortive Effects Of Meditation Apps, Kyle Hart

Honors Undergraduate Theses

We have investigated two different smartphone meditation apps to determine if they have any effects on stress and check if they are a viable tool that users can engage with to cope with stress during a work break. The dependent variables being measured include affective and cognitive restoration. The control group performed a coloring activity using a mandala figure. The experimental conditions engaged in app guided meditation through either 10% Happier or Calm. Both are health apps that are intended to help users practice a variety of mindfulness meditation exercises and help build healthy habits. This research focused on a …

The Effect Of A Senolytic Drug On Messenger Rna And Micro Rna Expression In Perigonadal Adipose Tissue Of Young And Old Mice, Catalina Hernandez

Honors Undergraduate Theses

As we face an expanding elderly population and increased age-related chronic diseases, we must seek solutions that address interconnected problems. Dasatinib plus quercetin (D+Q), a novel combination drug, is a proposed solution to improve the health and longevity of aged individuals with minimal side effects, exceptional efficacy, and maximum convenience. In this experiment, intermittent D+Q treatment was completed on young and old mice. RNA was extracted from perigonadal adipose tissue and cDNA libraries of mRNA and miRNA were made. Real-time quantitative polymerase chain reaction was used to assess relative gene expression for mRNA and miRNA pertaining to cell senescence, inflammation, …

Comparing Domestic Human Trafficking Policy Of States Party To The Palermo Protocol, Siera N. M. Himmerich

Honors Undergraduate Theses

Human Trafficking involves the various forms of coercion and force against millions of individuals all over the world into situations of unpaid labor, sexual exploitation, and organ sales. Attention to the phenomenon is relatively new and there is complexity both in how to address it and study it. When looking at human trafficking, issues of development, poverty, immigration, gender, international cooperation, social stigma, among others, are considered.

The purpose of this research paper is to compare and analyze local law interpretations of the Protocol to Prevent, Suppress and Punish Trafficking in Persons Especially Women and Children, supplementing the United Nations …

Development Of A Computer Algorithm For Generation Of Primers For Nucleic Acid Sequence Based Amplification (Nasba), Rohit Karnati

Honors Undergraduate Theses

Nucleic acid sequence based amplification (NASBA) is a primer based isothermal method of RNA/DNA amplification. Currently, primer design for NASBA has been restricted to hand creating sequences of oligonucleotides that must follow a set of rules to be compatible for the amplification process. This process of hand-creating primers is prone to error and time intensive. The detection of mutants, post amplification, also offers a benefit in point of care scenarios and the design of hybridization probes for sequences in the region of amplification is also an erroneous and time intensive process. By creating a program to design primers and hybridization …

Nature Contentedness Through Nature's Affordances, Fatima Khan

Honors Undergraduate Theses

There have been many studies conducted in the realm of nature that look at explanations behind human beings’ tendency to revert to nature as a way to relieve themselves from the real world while giving them feelings of well-being and positive emotions for a place. This study aimed to explore how humans feel more presence while also using this information to explore a more nature-oriented environment and the influence this has on human behavior. The present study is determining whether engaging with affordances of nature increase an individuals’ sense of presence. It was hypothesized that individuals that spend more time …

Interventions For Cultivating Civility In The Healthcare Team: Review Of The Literature, Elizabeth Knapp

Honors Undergraduate Theses

OBJECTIVE: The aim of this literature review was to examine the most current research regarding effective, evidence-based programs for reducing incivility among the healthcare team, particularly nurses. BACKGROUND: Incivility in the work environment is linked to a variety of negative outcomes, including diminished productivity, impaired judgement, and reduced employee retention. Incivility is especially detrimental to the healthcare team because it is correlated with decreased quality of patient care and increased medical errors. Despite regulations and statements made by the Joint Commission and the American Nurses Association to combat this serious problem, incivility continues to plague healthcare. METHODS: …

Investigating Aggression In Huntington Disease, Chloe E. Larochelle

Honors Undergraduate Theses

Huntington Disease (HD) is a neurodegenerative disorder that is caused by a CAG trinucleotide repeat expansion in the huntingtin gene. The onset of the disease is defined by the presence of motor deficits, such as chorea. However, cognitive and psychiatric symptoms often develop before motor onset and typically have a larger impact on patient quality of life. Psychiatric symptoms include depression, anxiety, and OCD, but also aggression and irritability, which have been comparatively understudied due to stigma. Currently, treatments to modify these behaviors in premanifest HD patients are not consistently effective and often have side effects, creating a need for …

The Relationship Between Community Health Worker Supply And The Rate Of Preventable Hospitalizations Of Rural Latinos With Diabetes, Danielle O. Mapp

Honors Undergraduate Theses

The ever-increasing prevalence of diabetes mellitus and its associated healthcare costs in the United States has led to our healthcare system's need for cost-effective health resources and chronic disease management. The interventions of Community Health Workers (CHWs) can cost-effectively improve population health and prevent the unnecessary utilization of some medical services especially in rural, low-income, minority populations, where there is often limited access to healthcare. The purpose of this study is to investigate the relationship between the number of total CHWs in rural counties and the mean diabetes-related preventable hospitalization rates in Latino patients diagnosed with diabetes in those rural …

Collegiate Leadership And Involvement At Ucf: A Study On Leadership Limitations, Benefits, And Creating Balance, Alyssa J. Marchione

Honors Undergraduate Theses

The purpose of this study is to explore the relationship between student leadership at the University of Central Florida, and the benefits and drawbacks that may result from this involvement. Student leadership is defined as the number of clubs and organizations a student is involved in and how many roles or titles a student has in those organizations. Student leadership benefits is defined as students feeling a higher sense of self efficacy, a greater chance of post-graduation success, and feeling as if they earned more opportunities due to their student leadership. Drawbacks of student leadership include feeling overworked, stressed, burnt …

The Effects Of Roundup On The Life History, Stress Response, And Immune Function Of The Yellow Fever Mosquito, Aedes Aegypti, Lindsay E. Martin

Honors Undergraduate Theses

Aedes aegypti mosquitoes, vectors for many human diseases, begin life as larvae developing in water, potentially exposed to runoff with herbicides and pesticides. This study serves as a novel investigation into the transstadial effects of exposure to Roundup on A. aegypti life history, immunity, and stress response and aims to account for these effects in an R0 model for vectorborne disease transmission. Prior work has shown that Roundup negatively affects mosquito life history. I hypothesized that larval exposure to the maximum sublethal dose of Roundup (7189µg/L) would negatively impact A. aegypti life history, immunity (candidate gene approach), and stress response …

Coping Mechanisms In Graduate School Discipline Specific Comparison, Sandra P. Montenegro

Honors Undergraduate Theses

Psychological research has studied the effects of college academic demands on students' wellbeing through the moderating role of coping mechanisms. This study provides further insight by focusing on coping mechanisms among graduate students from different fields, including humanities, STEM, and social sciences. Participants were recruited at the University of Central Florida (n=97). They answered an online survey assessing the prevalence of academic stressors, the use of different coping mechanisms, and strain outcomes, including somatic symptoms, insomnia, and burnout. STEM students reported higher organizational constraints and higher interpersonal conflict compare to students in other fields. Arts and humanities students reported higher …

Using Children's Literature To Support Social And Emotional Learning In Third Through Sixth Grade Classrooms, Hayley L. Paljug

Honors Undergraduate Theses

This research examined the use of award-winning children’s literature for social and emotional learning, focusing on its use for children in third through sixth grades. The world is ever-changing, and, as a result, the need for children to learn necessary social and emotional skills continues to increase. These skills include, but are not limited to, perseverance, friendship, grit, caring, and the like. It has been found that teaching social and emotional skills through bibliotherapy is an engaging and successful method that can be used by schools and teachers. Teachers or other educational stakeholders can use this document to begin to …

Exploring The Impact Of Pre-Exposure Prophylaxis Related To Sexual Behavior In College Men, Dalton J. Poe

Honors Undergraduate Theses

Pre-exposure prophylaxis (PrEP) is an effective tool for preventing human immunodeficiency virus (HIV) acquisition in sexually active at-risk individuals such as men who have sex with men (MSM). The purpose of this study is to examine factors associated with intent to engage in risky sexual behavior among HIV-negative college aged (18-24) MSM who are currently adherent to PrEP or who have expressed interest in the future adoption of PrEP. A multiracial/ethnic sample of 31 men expressing interest in the adoption of PrEP and 6 men currently taking PrEP completed a quantitative survey identifying key themes regarding attitudes towards PrEP and …

Assessing 3d Printability Of Bioinks, Nicole Ramirez

Honors Undergraduate Theses

The field of tissue engineering (TE) is continuously improving through the use of additive manufacturing techniques (AM) such as three-dimensional (3D) bioprinting. The 3D bioprinter has significantly gained attention in the TE field because it is more efficient than regenerative medicine and is readily available as opposed to organ transplants. Working like a conventional 3D printer, the 3D bioprinter is able to dispense material layer by layer from the bottom up with the printing head able to move in the X, Y, and Z direction. This movement allows for the fabrication of structures with complex geometries. In this study, the …

Genetic Structure Of Green Sea Turtle (Chelonia Mydas) Foraging Aggregations On The East Coast Of Florida, Monica R. Reusche

Honors Undergraduate Theses

The genetic structure of juvenile green turtles (Chelonia mydas) foraging on the east coast of central Florida is not well understood, nor has it been examined over time. In the last three decades, the dramatic increase in the number of green sea turtle nests in Florida, in association with other population parameters, has led to this species being down-listed under the Endangered Species Act from “endangered” to “threatened” in the northwest Atlantic. However, it was unclear if the exponential growth in Florida nest numbers had any influence on the genetic structure of juveniles in nearby foraging aggregations. To …

How Great Power Politics Influences Refugee Policy: Assessing The U.S. Foreign Policy Implications Of Differing Responses To The Venezuelan Migration Crisis In Colombia, Peru, And Brazil, Suhan M. Rosario

Honors Undergraduate Theses

Why are Venezuelan Migrants accepted in neighboring Colombia, but not in other countries in South America? It is true that Colombia and Venezuela are similar in language, culture, and customs, but this is true across the continent. There has been literature published on the size of the crisis, and where they are going. Here, I will assess why the Colombian government is more accepting of Venezuelan migrants, even when this is not popular in Colombia or any other country in South America.

My argument is that US foreign policy has caused Colombia to be more accepting of Venezuelans than neighboring …