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Characterization Of Electrical And Optical Properties Of Europium Oxide, Mshari H. Alhsawi
Characterization Of Electrical And Optical Properties Of Europium Oxide, Mshari H. Alhsawi
Graduate Thesis and Dissertation post-2024
Oxide semiconductors with high optical transparency hold significant promise for a broad range of optical applications. Among them, europium oxide (Eu₂O₃ ) has garnered considerable attention for its potential in transistor devices, resistive random-access memory (RRAM), white light-emitting devices, and erasable optical storage systems. Additionally, Eu₂O₃ is employed in nanoscale applications, such as photoactive coatings and high-k dielectrics. Its advantageous dielectric properties and high transmittance make it particularly well-suited for capacitor fabrication. The material also exhibits resistive switching behavior and notable optical absorption, further enhancing its relevance for optoelectronic devices.
In this study, Eu₂O₃ thin films were deposited using RF …
Machine Learning-Enhanced Optimization For The Real-Time, Secure, And Efficient Operation Of The Energy-Water-Hydrogen Nexus, Mostafa Goodarzi
Machine Learning-Enhanced Optimization For The Real-Time, Secure, And Efficient Operation Of The Energy-Water-Hydrogen Nexus, Mostafa Goodarzi
Graduate Thesis and Dissertation post-2024
Given the escalating urgency of climate change, our research addresses the imperative need to curb carbon emissions, particularly from the electricity sector, which accounts for a quarter of total emissions in the U.S. We propose integrated systems, such as the energy-water nexus (EWN) and an innovative concept known as the energy-water-hydrogen (EWH) nexus, which integrates renewable energy sources (RESs) with green hydrogen production through water electrolysis. These concepts align seamlessly with the nation’s commitment to global climate agreements, including the Paris Agreement. Furthermore, green hydrogen—a clean and efficient energy source produced via water electrolysis powered by renewable energy—emerges as a …
Advanced Deep Learning Algorithms For Medical Imaging Applications: Tumor And Organ At Risk Segmentation, Ilkin Sevgi Isler
Advanced Deep Learning Algorithms For Medical Imaging Applications: Tumor And Organ At Risk Segmentation, Ilkin Sevgi Isler
Graduate Thesis and Dissertation post-2024
Accurate segmentation of tumors and organs at risk (OAR) remains a fundamental challenge in medical image analysis, directly affecting diagnostic accuracy, treatment planning, and patient outcomes. Although automated segmentation methods have advanced, they still face difficulties in anatomically complex regions and in cases with low tissue contrast. A major contributor to this variability is intra- and interobserver disagreement, introducing uncertainty into annotations and model predictions.
This dissertation investigates the role of segmentation uncertainty and its impact on model reliability, interpretability, and clinical integration, with a focus on lung, pancreatic, and head and neck cancers.
The first component introduces uncertainty-aware segmentation …
Gradient-Based Optimization And Control Of Systems With Two Decision-Makers And Delayed Information, Mohammad Safayet Hossain
Gradient-Based Optimization And Control Of Systems With Two Decision-Makers And Delayed Information, Mohammad Safayet Hossain
Graduate Thesis and Dissertation post-2024
In today’s world systems are complex in nature, often involving two or more decision-makers (DMs) each attempting to optimize the performance of the system using an objective function that reflects its own preferences and is usually different from the other. Such systems are very common in power, microeconomics, and other systems. The focus of this research is how such systems are optimized and how the results of optimization are implemented in practice. Without loss of generality, we consider systems with two DMs, each attempting to optimize the system’s by minimizing its own objective function. The solution of these types of …
Pedestrian Monitoring And Crossing Intention Prediction At Intersections Using Computer Vision And Deep Learning, Ahmed Abdelrahman
Pedestrian Monitoring And Crossing Intention Prediction At Intersections Using Computer Vision And Deep Learning, Ahmed Abdelrahman
Graduate Thesis and Dissertation post-2024
Ensuring the safety of Vulnerable Road Users (VRUs), including pedestrians, bicyclists, and E-scooter riders, at intersections is crucial for sustainable and efficient urban mobility. Despite recent advancements in transportation technologies, accurately understanding and predicting human behavior at intersections remains challenging, resulting in unsafe interactions, crossing violations, and diminished trust in traffic systems. This dissertation presents an integrated approach comprising three novel frameworks: VRUCrossSafe, VRU-CIPI, and the Video-to-Text Pedestrian Monitoring (VTPM) system, collectively addressing critical gaps in intersection safety, VRU behavior prediction, and privacy-preserving traffic monitoring. First, VRUCrossSafe introduces a real-time intersection safety solution utilizing computer vision and ensemble machine learning …
A Novel Au-Decorated Ni-Mof For The Photo And Electrochemical Treatment Of Mc-Lr, Stephanie Stoll
A Novel Au-Decorated Ni-Mof For The Photo And Electrochemical Treatment Of Mc-Lr, Stephanie Stoll
Graduate Thesis and Dissertation post-2024
Microcystins (MCs) are toxins produced by cyanobacteria commonly found in harmful algal blooms (HABs) threatening many surface waters. Conventional removal methods, including membrane filtration and activated carbon, are costly and only achieve phase separation. This study introduces a novel Au-decorated Ni-metal-organic framework (Au/Ni-MOF) as a platform for the multi-modal treatment of MC-Leucine Arginine (MC-LR), utilizing photodegradation (PD), electrochemical oxidation (EO), and photoelectrochemical oxidation (PEO) by evaluating and comparing their effectiveness.
A 4 cm2 Au/Ni-MOF achieved complete photodegradation of 20 ppb of MC-LR in 7 mL of DI water with a degradation rate constant of 0.0599 min-1 under 35,000 …
Continuously Variable Series Reactor Modeling And Application, Mohammadali Hayerikhiyavi
Continuously Variable Series Reactor Modeling And Application, Mohammadali Hayerikhiyavi
Graduate Thesis and Dissertation post-2024
In today's rapidly evolving energy landscape, the Continuously Variable Series Reactor (CVSR) emerges as a vital tool for enhancing the stability and efficiency of power systems. This proposal presents a detailed investigation into the operational characteristics and performance optimization of CVSR through advanced modeling techniques. The Continuously Variable Series Reactor (CVSR) offers a unique capability to regulate the reactance of an AC circuit through the magnetizing characteristic of its ferromagnetic core. By utilizing both AC and DC windings, the CVSR effectively controls power flow, dampens oscillations, and balancing the voltage within the power grid. To effectively integrate CVSR into grid …
Tail-Imbalance Diffusion Equalizer For Class-Balanced Generation, Chinmay Dhanraj Nehate
Tail-Imbalance Diffusion Equalizer For Class-Balanced Generation, Chinmay Dhanraj Nehate
Graduate Thesis and Dissertation post-2024
Real-world image corpora are often imbalanced. On long-tailed datasets, the head class can outnumber the tail by a large margin, and a vanilla diffusion probabilistic model (DPM) consequently loses fidelity and diversity on rare categories, undermining controllable generation. To address this gap, we present Tail Imbalance Diffusion Equalizer (TIDE), a training framework that restores class balance without discarding data or adding extra training stages. Our contribution is threefold: (i) score field rebalancing, where we embed class-prior knowledge into a mixing matrix that routes gradients toward minority classes, with this class-prior knowledge consisting of the empirical label frequencies in the training …
A Variable Resistance Suit (Vars) And An Extendable Prosthetic Arm (Expa) For Physical Rehabilitation And Assistance, Ibrahim F. Kadhim
A Variable Resistance Suit (Vars) And An Extendable Prosthetic Arm (Expa) For Physical Rehabilitation And Assistance, Ibrahim F. Kadhim
Graduate Thesis and Dissertation post-2024
This dissertation presents the design, development, and evaluation of two novel wearable assistive technologies – Variable Resistance Suit (VARS) and the Extendable Prosthetic Arm (EXPA) – to improve rehabilitation outcomes and functional independence of individuals with musculoskeletal impairment. VARS is a modular, lightweight, and wearable resistance training system that applies bidirectional, speed-dependent, and variable mechanical resistance to the elbow and knee joints. It addresses the limitations of traditional resistance equipment by offering a portable, safer, and more accessible alternative. Importantly, VARS enables targeted engagement of specific muscle groups during training, minimizing the risk of overloading adjacent or compensatory muscles. VARS …
Interpretation And Control Of Ai Model Behavior Through Direct Adjustment Of Latent Representations, Austin Davis
Interpretation And Control Of Ai Model Behavior Through Direct Adjustment Of Latent Representations, Austin Davis
Graduate Thesis and Dissertation post-2024
This dissertation investigates the structures and mechanisms underpinning the latent space representations that emerge within Generative Pretrained Transformer (GPT) models. Addressing the broader goal of enhancing AI trustworthiness through transparency, accountability, and controllability, we focus on techniques to understand, quantify, and manipulate these latent space representations. Through a series of analyses, we examine several chess-playing GPT models as controlled testbeds, leveraging their structured decision space to explore emergent representations and decision-making processes.
Key contributions include a mechanistic analysis of the attention heads and latent representations, the development of novel metrics for evaluating intervention outcomes, and the application of linear probe …
Cnn's Portrayal Of The Build Back Better Act, Alexander J. Toj-Moody
Cnn's Portrayal Of The Build Back Better Act, Alexander J. Toj-Moody
Graduate Thesis and Dissertation post-2024
The purpose of this study is to investigate the effect of CNNs representation of the Build Back Better Act and its failure to pass senate reconciliation during the fall of 2021. The Build Back Better Act was a piece of legislation that intended to fix America’s social infrastructure, such as investing in education, the environment, expanded healthcare, etc. The bill ultimately failed and its replacement, the Inflation Reduction Act of 2022, cut numerous benefits that were proposed within the Build Back Better Act. Examination of broadcast transcripts during this period of time find an operationally liberal framing, though the focus …
Sex Estimation Using Linear And Geometric Morphometric Analyses Of The Adult Human Talus, Melissa N. Marks
Sex Estimation Using Linear And Geometric Morphometric Analyses Of The Adult Human Talus, Melissa N. Marks
Graduate Thesis and Dissertation post-2024
Estimating biological sex is an essential first step when analyzing human remains in both forensic and archaeological contexts. While the pelvis and skull are traditionally used for this purpose, they are not always present or sufficiently preserved to permit analysis. The talus is sexually dimorphic and can yield highly accurate sex estimates, making it a promising alternative skeletal element for sex estimation. As there is currently no accepted protocol for sex estimation using the talus, the present study attempts to replicate and validate existing methods using linear and three-dimensional landmark data, while comparing data from ancient Maya (n=16), ancient Egyptian …
Differential Interferon Synthesis And Signaling Between Parainfluenza Virus Acute And Persistently Infected Cells, Vonisha Kaigler
Differential Interferon Synthesis And Signaling Between Parainfluenza Virus Acute And Persistently Infected Cells, Vonisha Kaigler
Graduate Thesis and Dissertation post-2024
RNA virus infections can transition from an initial acute infection to a prolonged or persistent infection, in which infected cells survive and continue to produce progeny virus. This presents a major clinical problem as persistently infected (PI) cells extend viral shedding, maintain inflammation, and provide potential sources for new viral variants. The RNA virus, Parainfluenza virus 5 (PIV5), with mutations in the P/V gene region (P/V mutant) is a strong inducer of antiviral responses. Interestingly, over time, there is an emergence of cells that survive as P/V mutant PI cells. Given that changes in innate immune signaling pathways can occur …
'How To Mother': Televisual Reimaginings Of Black Matriarchy In The Real Housewives Of Potomac, Kalijah Rahming
'How To Mother': Televisual Reimaginings Of Black Matriarchy In The Real Housewives Of Potomac, Kalijah Rahming
Graduate Thesis and Dissertation post-2024
Since the initial launch of The Real Housewives of Orange County in 2006, Bravo’s The Real Housewives franchise has soared to previously unimaginable heights. With 11 American installments, 30 international adaptations, and 25 current spin-offs, it is clear that even viewers who are relatively unfamiliar with The Real Housewives franchise may find themselves inadvertently swept up in their world due to the popularization of their catchphrases and gifs on social media platforms like Instagram, Twitter, and Facebook. In addition to carefully shaping popular culture, members of this franchise have even altered the conditions of the entertainment industry’s practices for the …
The Path Of Peace: Non-Violent Methods Of Play In Indie Video Game History, Ryu R. Yamamoto
The Path Of Peace: Non-Violent Methods Of Play In Indie Video Game History, Ryu R. Yamamoto
Graduate Thesis and Dissertation post-2024
This research project investigates the cultural and historical significance of independently published Japanese bullet-hell/danmaku games from the 2000s and 2010s. This project highlights gaps in current game histories, particularly surrounding the influence of these games on heralded contemporary titles like Undertale (2015). The significance of independently published “doujin” Japanese digital media, notably the Touhou Project series, is often overlooked in American game studies contexts. Examining these underexplored games aims to enrich the understanding of cultural-historical games research, particularly in positioning lesser-known and lower-budget games, and contribute to the broader discourse on cross-cultural interactions within the gaming community. Comparative analyses of …
A Forgotten Kairos: Rhetorical Memory In 16th Century Europe, Phillip Martin
A Forgotten Kairos: Rhetorical Memory In 16th Century Europe, Phillip Martin
Graduate Thesis and Dissertation post-2024
In 16th century Europe the nearly 2000-year-old discipline of rhetoric, still a pillar of education, underwent significant change. One of the more curious changes occurred in rhetoric’s subdivision known as memory, memoria, that is, memory’s “artificial” cultivation. During the 16th century rhetorical memory was paradoxically both maximized and marginalized as a discipline. And by the early 17th century memoria was all but extinct as a branch of rhetoric. The causal mechanisms of this transformation remain underexamined, particularly by rhetoric and composition scholars, and most explanations remain unclear and uncompelling. Accordingly, this thesis attempts a new approach …
Roles Of Ifn-Alpha/Beta And Ifn-Gamma In Enhancing And Inhibiting Nk Cell Mediated Killing Of Oncolytic Virus Infected Tumor Cells, Elisabeth M. Shiffer
Roles Of Ifn-Alpha/Beta And Ifn-Gamma In Enhancing And Inhibiting Nk Cell Mediated Killing Of Oncolytic Virus Infected Tumor Cells, Elisabeth M. Shiffer
Graduate Thesis and Dissertation post-2024
Type I interferon (IFN-I) and interferon-gamma (IFN-γ) are potent cytokines that can be produced by virus-infected cells and Natural Killer (NK) cells, respectively. The relative roles of these two IFNs in promoting NK cell killing of tumor cells was tested in the context of combining particle-based ex vivo expanded PM21-NK cells and infection with oncolytic Parainfluenza virus 5 (PIV5). Activated NK cells produce IFN-γ, which can upregulate NK cell inhibitory ligands on tumor cells and reduce NK cell killing. We hypothesized that resistance of tumor cells to NK cell killing could be overcome by expression of the PIV5 V protein, …
A Community-Based Wellness Program To Increase Exercise Adherence For Menopausal And Postmenopausal Women: A Mixed-Methods Pilot Study, Kristin M. Badillo
A Community-Based Wellness Program To Increase Exercise Adherence For Menopausal And Postmenopausal Women: A Mixed-Methods Pilot Study, Kristin M. Badillo
Graduate Thesis and Dissertation post-2024
Evidence exists that long-term commitment to an exercise routine is beneficial. Contrarily, there is a notable lack in exercise adherence among menopausal and postmenopausal women. Though research has thoroughly examined the reasons why menopausal and postmenopausal women may not be committed to an exercise routine, it remains unclear what motivates those who are adherent. This pilot study employed a mixed-methods design through administering surveys and conducting in-person focus group interviews. Additionally, an 8-week buddy system was implemented to assess the role of social support and its effect on exercise adherence. For quantitative data collection, a total of 7 participants enrolled …
Limitations Support Learning: A Design Based Study Of Ethically Scaffolded Generative Ai Tools For Long Form Argumentation And Metacognition, Lindsay Konradt
Limitations Support Learning: A Design Based Study Of Ethically Scaffolded Generative Ai Tools For Long Form Argumentation And Metacognition, Lindsay Konradt
Graduate Thesis and Dissertation post-2024
This design‑based research study implemented and refined an instructional model that used generative AI (GAI) tools within a nine‑week AP Capstone Seminar argumentation unit. The model combined teacher feedback and modeling, structured reflection tasks (including AI‑assisted reflection), AI assisted editing, AI-assisted literature searches, and counterargument support using restricted chatbots. During the nine week period, responsibility for feedback moved from teacher and AI supported scaffolding to student driven writing practice and revision. Data collection focus on four advanced high school students at a Florida public high school, including multiple drafts, GAI input and output logs, reflections, and pre‑ and post‑unit semi‑structured …
Predicting Past And Future Anthropogenic Global Harvest And Land Use, Michelle Bardales Cruz
Predicting Past And Future Anthropogenic Global Harvest And Land Use, Michelle Bardales Cruz
Graduate Thesis and Dissertation post-2024
Anthropogenic appropriation of natural lands has long sustained human populations and activities. Human use of the environment has resulted in the degradation of green spaces and depletion of natural, particularly plant-based, resources. Human appropriation of net primary production (HANPP) is a globally available, spatially explicit measure of this human-driven extraction and diversion of plant biomass through harvesting (HANPPharv) and land use change (HANPPluc). Models for HANPP have been limited temporally (e.g., a year) or in terms of complexity (e.g., one predictor). In this study, I predict HANPPharv and HANPPluc from 1960 to 2010 at …
Student-Athlete Vs Athlete-Student: Differences In Athletic Retirement Expectations, Terrie L. Bradshaw
Student-Athlete Vs Athlete-Student: Differences In Athletic Retirement Expectations, Terrie L. Bradshaw
Graduate Thesis and Dissertation post-2024
The purpose of this qualitative, phenomenological Dissertation in Practice was to define the terms student-athletes and athlete-student by discovering any differences in non-cognitive variables between the two groups. Additionally, this study attempted to identify any differences in career transition expectations between student-athletes and athlete-students. Thirteen NCAA athletes from various universities across the United States were included. With the use of one-on-one semi structured interviews, five themes emerged. The themes that emerged were 1) Both types of athletes attend college for different reasons. 2) Differences in level of commitment. 3) Both types of athletes strive for academic success. 4) Different expectations …
Fit Index Criteria For Multisample Analysis In Sem With Ordinal Data: A Monte Carlo Simulation Study, Suat Babayigit
Fit Index Criteria For Multisample Analysis In Sem With Ordinal Data: A Monte Carlo Simulation Study, Suat Babayigit
Graduate Thesis and Dissertation post-2024
Measurement invariance is crucial for valid group comparisons in structural equation modeling (SEM), yet testing invariance becomes challenging when using ordinal data. This dissertation evaluates the adequacy of widely used fit index difference criteria (ΔCFI, ΔRMSEA, ΔSRMR) for multisample invariance testing with ordinal indicators. Traditional Δ fit cutoff thresholds were established based on continuous, normally distributed data, but ordinal measures can distort invariance conclusions. Monte Carlo simulations address this issue by manipulating a comprehensive set of conditions: sample sizes (200, 400, 1000), group size ratios (equal vs. unequal), model complexity (low vs. high), underlying distributions (normal vs. nonnormal), Likert scale …
Integrating Education For Sustainable Development Into Elementary Curriculum Through Transdisciplinary Learning: A Case Study Of Teachers At Designated Green Schools, Amanda Ferguson
Graduate Thesis and Dissertation post-2024
The rising number of sustainability-focused jobs in the United States has underscored the need for greater exposure to Education for Sustainable Development in early education. While higher education and secondary schools offer courses on sustainability and the environment, elementary students have limited opportunities to engage with these topics. This embedded multiple-case study examined the role of Education for Sustainable Development in elementary classrooms, specifically through transdisciplinary lessons. The research was guided by the question: How do elementary teachers in county-designated Green Schools in a Florida district use transdisciplinary lessons to teach sustainability within their existing curriculum?
Using the theoretical framework …
A Case Study Of Grades 3-4 English Language Arts Teachers' Interpretations Of Educational Policy And Their Pedagogical Choices In Literacy Instruction, Priscilla Develder
A Case Study Of Grades 3-4 English Language Arts Teachers' Interpretations Of Educational Policy And Their Pedagogical Choices In Literacy Instruction, Priscilla Develder
Graduate Thesis and Dissertation post-2024
The purpose of this qualitative case study was to explore how elementary school teachers in a Florida public school district made sense of Florida’s House Bill 1467: K-12 Education (HB 1467) and how their interpretations shaped their reading and writing pedagogy. Guided by Karl Weick’s (1995) Sensemaking Theory as a theoretical lens for understanding these interpretations, the study examined how teachers navigated the complexities of policy implementation within the context of their daily classroom experiences. Participants included six third- and fourth-grade English Language Arts (ELA) teachers from four elementary schools within a Florida public school district. Data was collected …
Instructional And Motivational Factors Predicting Deep Learning Approaches In Pre-Clinical Medical Students, Kenneth L. Dearman
Instructional And Motivational Factors Predicting Deep Learning Approaches In Pre-Clinical Medical Students, Kenneth L. Dearman
Graduate Thesis and Dissertation post-2024
Pre-clinical medical students predominantly employ surface learning approaches, focusing on memorization and exam preparation rather than developing a deep understanding of medical knowledge. This study employed a correlational design comparing two courses with different instructional approaches using expectancy-value theory to examine how instructional methods and motivational factors predict deep learning approaches among 148 pre-clinical medical students at a College of Medicine in the Southeastern United States. Initial results showed that the three separate constructs in task motivation (expectancy beliefs, values, and cost) did not mediate the relationship between active instructional methods and deep learning strategies. Instead, active learning was a …
Nou La, We Are Here: A Phenomenological Study On Haitian Students' Identity Development In College, Norma J. Altidor
Nou La, We Are Here: A Phenomenological Study On Haitian Students' Identity Development In College, Norma J. Altidor
Graduate Thesis and Dissertation post-2024
The United States has seen an increase of individuals migrating from Haiti in search of better opportunities for themselves and their families (Camarota, 2024; Ogunwole, Battle & Cohen, 2017). That rise has correlated with an increase in the number of Haitian students enrolling in American higher education institutions. There are many published studies on the experiences of minorities based on race (Harper & Quaye, 2007) compared to studies on ethnically diverse students (Dennis, Phinney & Chuateco, 2005). Existing literature shows that immigrant youth and first-generation Americans often identify more with their ethnicity than their race (Tatum, 1997). As such, there …
Examining The Relationship Between Volunteerism And Revenue Streams In Youth-Centered Nonprofit Organizations: An Analysis Of Fundraising Revenue, Program Service Revenue, And Government Grants, Stephanie Aguguo-Orelus
Examining The Relationship Between Volunteerism And Revenue Streams In Youth-Centered Nonprofit Organizations: An Analysis Of Fundraising Revenue, Program Service Revenue, And Government Grants, Stephanie Aguguo-Orelus
Graduate Thesis and Dissertation post-2024
This study examined the relationship between volunteerism and revenue streams in youth-centered nonprofit organizations (NPOs) in the United States. Utilizing financial data from IRS Form 990 filings spanning 2014 to 2023, the research analyzes how the number of annual volunteers impacts three primary revenue sources: donations, program service revenue, and government grants. Fixed-effects regression models are employed to evaluate these relationships across the full study period and in pre- and post-COVID-19 subsamples. The study also investigates the association between volunteerism and revenue diversification using the Herfindahl-Hirschman Index (HHI). Findings reveal a positive and statistically significant relationship between volunteer involvement and …
Decreasing Administrative Burdens For Promoting Social Equity: Three Essays On Innvations In Public Service Provision, Kyungmin Lee
Decreasing Administrative Burdens For Promoting Social Equity: Three Essays On Innvations In Public Service Provision, Kyungmin Lee
Graduate Thesis and Dissertation post-2024
This dissertation investigates three aspects of administrative burdens in public service delivery and explores how these burdens—which often discourage eligible individuals from accessing needed services—relate to individuals' perceptions of and behaviors toward those burdens and ultimately to user outcomes. The first essay examines whether a shift from in-person to virtual service modalities imposes additional administrative burden—digital administrative burden—for service users. Using the secondary data from the 2022 “Survey of Citizens’ Perceptions of Public Administration” conducted in South Korea, the study applies Coarsened Exact Matching (CEM) to assess the relationship between service modality and digital administrative burden. The findings suggest no …
Preserving Florida History In 3d: A Digital Public History Project Preserving Paleo-Native American Artifacts And Jack West Architecture From Warm Mineral Springs, Florida, Trevor D. Colaneri
Preserving Florida History In 3d: A Digital Public History Project Preserving Paleo-Native American Artifacts And Jack West Architecture From Warm Mineral Springs, Florida, Trevor D. Colaneri
Graduate Thesis and Dissertation post-2024
This thesis project examines low-cost photogrammetry and 3D walkthrough tours to preserve a collection of artifacts and buildings from Warm Mineral Springs, Florida. The documented objects and structures consist of a small collection of artifacts from Warm Mineral Springs currently held by Florida’s Bureau of Archaeological Research and three buildings designed by noted architect Jack West, a Sarasota School of Architecture member, which suffered extensive damage from a category five hurricane in 2022. Warm Mineral Springs is an archaeologically significant site and is one of the few sites in Florida that demonstrate significant paleo-Native American cultural remains that has also …
Investigating The Role Of Selenium-Dependent Stickland Reactions In Clostridioides Difficile Bioenergetics, Dominika Dzurny
Investigating The Role Of Selenium-Dependent Stickland Reactions In Clostridioides Difficile Bioenergetics, Dominika Dzurny
Graduate Thesis and Dissertation post-2024
Clostridioides difficile is an anaerobic, spore-forming bacterium and one of the leading causes of antibiotic- associated diarrhea. Colonization depends on the metabolism of certain nutrients in the host gut, namely amino acids and carbohydrates. C. difficile ferments amino acids as an integral part of its metabolism via Stickland reactions, utilizing the selenoproteins D-proline reductase (Prd) and glycine reductase (Grd) to generate energy. Specificity of selenocysteine incorporation reflects the intracellular levels of selenophosphate, the activated selenium donor synthesized by selenophosphate synthetase (SelD). SelD is coincidentally a selenoprotein itself, containing a UGA codon at position 17 (Sec-17). The functional and physiological importance …