Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network

Open Access. Powered by Scholars. Published by Universities.®

University of Central Florida

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 301 - 330 of 41626

Full-Text Articles in Entire DC Network

Music Interventions For Critically Ill Patients: Evaluating Effects Of Music On Psychoemotional Symptoms In Critically Ill Patients Receiving Respiratory Support, Allyson Crighton Jan 2026

Music Interventions For Critically Ill Patients: Evaluating Effects Of Music On Psychoemotional Symptoms In Critically Ill Patients Receiving Respiratory Support, Allyson Crighton

Honors Undergraduate Theses

Critically ill adults receiving respiratory support in intensive care units (ICUs) frequently experience psychoemotional disturbances such as agitation, anxiety, and delirium, which contribute to prolonged ventilation, increased sedative use, and adverse patient outcomes. While pharmacologic management remains standard practice, associated risks including oversedation and delirium highlight the need for safe, complementary interventions. Emerging evidence suggests that music-based interventions may offer a non-invasive, cost-effective strategy to reduce psychological or emotional distress in this vulnerable population. This integrative literature review examined the effects of music interventions, including passive music listening and structured music therapy, on agitation and related psychoemotional outcomes in critically …


Parenting Stress And Its Association With Parental Technoference: An Integrative Literature Review, Emily S. Machuca Jan 2026

Parenting Stress And Its Association With Parental Technoference: An Integrative Literature Review, Emily S. Machuca

Honors Undergraduate Theses

Introduction: Today, digital devices are a part of daily life, but can serve as a distraction that interrupts important relationships, a process referred to as technoference. In the context of parenting, device use during child interactions may reduce parental attentiveness and engagement, with potential implications for child development and behavior. Parenting stress may influence how and why parents engage with digital devices in the presence of their children. However, the association between parenting stress and parental technoference remains unclear in the current literature. This integrative literature review aimed to synthesize existing evidence examining the relationship between parenting stress and parental …


Bridging The Gap: Investigating The Impact Of Adequate Prenatal Care On Adverse Maternal Outcomes Among Black And African American Women, Ciaera Ambroise Jan 2026

Bridging The Gap: Investigating The Impact Of Adequate Prenatal Care On Adverse Maternal Outcomes Among Black And African American Women, Ciaera Ambroise

Honors Undergraduate Theses

The United States continues to face a maternal health crisis marked by persistent racial disparities, with Black women experiencing pregnancy-related mortality rates three times higher than those of White women. Despite national efforts to expand access to prenatal services, inequities in maternal outcomes remain, indicating that the quality of prenatal care may be as critical as its timing and frequency. The purpose of this thesis is to examine whether adequate prenatal care, compared to inadequate prenatal care, is associated with reduced adverse maternal outcomes among Black and African American women in the United States. Guided by a PICO question, this …


Examining The Effectiveness Of Icu Diaries In Reducing Post–Intensive Care Syndrome (Pics) Psychological Symptoms: A Rapid Review Of United States–Based Studies, Lananh Tran Jan 2026

Examining The Effectiveness Of Icu Diaries In Reducing Post–Intensive Care Syndrome (Pics) Psychological Symptoms: A Rapid Review Of United States–Based Studies, Lananh Tran

Honors Undergraduate Theses

Background: The growing recognition of Post-Intensive Care Syndrome (PICS) has prompted investigation into interventions, such as ICU diaries, to mitigate the long-term psychological effects of PICS. Intensive care unit (ICU) diaries – journals written by clinicians and loved ones during an ICU admission – are a tool that can help patients reconstruct the events of their critical care experience. Entries in the diary may include clinical updates, explanation of treatments, and encouraging words from loved ones or staff. Previous research in European countries found ICU diaries may be effective in reducing psychological effects post ICU admission.

Research question: The aim …


Photogrammetry: Accuracy And Precision Analysis Of Color And Rim Diameter Utilizing Various Cameras, Christina Threlkeld Jan 2026

Photogrammetry: Accuracy And Precision Analysis Of Color And Rim Diameter Utilizing Various Cameras, Christina Threlkeld

High Impact Practices Student Showcase Spring 2026

The goal of this paper is to test whether photogrammetry is a viable/affordable way to generate 3-D data sets suitable for research applications. Utilizing a sample of 10 ceramic rim sherds randomly selected out of 40 viable rim samples from the Rio Verde assemblage, I will generate 3-D models for 3 different technologies. From there I will test measurements by calculating rim diameters and consistency of color through Munsell readings The data collected will help determine what type of data can be extracted from 3-D renderings. In order to ensure accuracy, rim sherd diameter and Munsell data will be directly …


The Efficacy Of Travoprost/Timolol In Treating Glaucoma, Yasmin Emam, Sebastian Nieto, Arnav Jain, Chris Rodriguez, Angelia Koppenhoefer Jan 2026

The Efficacy Of Travoprost/Timolol In Treating Glaucoma, Yasmin Emam, Sebastian Nieto, Arnav Jain, Chris Rodriguez, Angelia Koppenhoefer

High Impact Practices Student Showcase Spring 2026

This project focuses on evaluating the effectiveness of DuoTrav, a fixed-combination ophthalmic medication containing Travoprost 0.004% and Timolol 0.5%, in the treatment of open-angle glaucoma and ocular hypertension. The purpose of the researcher's study was to examine how this combination therapy compares to a beta-blocker monotherapy in reducing intraocular pressure (IOP), which is a major risk factor for optic nerve damage and vision loss in glaucoma patients.

Key activities included reviewing the cause of glaucoma, analyzing the design and results of a completed and randomized clinical trial, and applying the findings to clinical practice.

One of the most important things …


Reliability Of Professor Ratings, Tridung Bui, Naomi Waddell, Diego Quinones, Kiran Pittan, Fabricio Escrich Jan 2026

Reliability Of Professor Ratings, Tridung Bui, Naomi Waddell, Diego Quinones, Kiran Pittan, Fabricio Escrich

High Impact Practices Student Showcase Spring 2026

No abstract provided.


Myth To Mindset: Comparing Perceptions Of Feminine Leadership In Hinduism And Christianity, Maya Arangath Jan 2026

Myth To Mindset: Comparing Perceptions Of Feminine Leadership In Hinduism And Christianity, Maya Arangath

High Impact Practices Student Showcase Spring 2026

This research project investigates the intersection of religion and feminine leadership by comparing barriers in Hinduism and Christianity found in their sacred texts. The purpose of the study is to identify if the customs followed in each tradition affects women in positions of authority in modern day. To uncover that, this project will use a two-part mixed methods approach. First, a primary source comparative analysis will be completed, followed by an in-depth interview focusing on the living theology. A key takeaway from the study so far is the nuanced ways each religion shows feminism. The study suggests that feminism is …


The Lifeboat Project Team 30: Introduction To Advertisement, Holland H. Roedema, Kenna Carlson, Jasmyne Iemnak Jan 2026

The Lifeboat Project Team 30: Introduction To Advertisement, Holland H. Roedema, Kenna Carlson, Jasmyne Iemnak

High Impact Practices Student Showcase Spring 2026

Our project highlights the research we have completed about the Lifeboat Project and strategic recommendations that would benefit them as an organization in terms of audience engagement and reach. In this presentation, we cover Strengths, Weaknesses, Opportunities, and Threats to the organization's social media content. We also include potential utilization of ad placement and budgeting the organization could use for Newspaper advertisement. And finally, we curated mock social media posts for the Lifeboat Project after our team conducted a public survey.The survey's results revealed common social media habits and preferences of individuals in our target audience. Our Service Learning Project …


The Skills That Win Championships: An Nba Team Winrate Prediction Analysis (2023-2024) ​, Royce A. Reeves, Thirumukelan Senthilkumar, Alsion Tafa Jan 2026

The Skills That Win Championships: An Nba Team Winrate Prediction Analysis (2023-2024) ​, Royce A. Reeves, Thirumukelan Senthilkumar, Alsion Tafa

High Impact Practices Student Showcase Spring 2026

This study examines the relationship between team performance metrics and win percentage in the 2023–24 NBA season. Using team level data sourced from NBA.com and Kaggle, we analyzed variables including shooting efficiency, rebounds, turnovers, and plus/minus. Exploratory data analysis was conducted to assess relationships and address potential collinearity. Multiple linear regression was used to model win percentage, followed by model selection to identify the most impactful predictors. The final model explains approximately 90% of the variation in team success and identifies plus/minus, three-point percentage, turnovers, and rebounds as significant factors. Results indicate that overall team performance three-point shooting, and limiting …


Constrained Freedom: Economic Strain, Time Control, And Perceived Autonomy In Life, Lorena E. Black Jan 2026

Constrained Freedom: Economic Strain, Time Control, And Perceived Autonomy In Life, Lorena E. Black

High Impact Practices Student Showcase Spring 2026

Autonomy is often framed as an individual capacity rooted in personal choice, discipline, and self-determination, with dominant cultural narratives positioning freedom as something earned through effort and responsibility. This study challenges that assumption by examining autonomy as a socially structured and unequally distributed condition shaped by material and temporal constraints. Drawing on classical and contemporary sociological frameworks—including Marx’s analysis of labor and material dependence, Weber’s account of disciplined rationality, and Antonio Gramsci’s concept of cultural hegemony—this research positions perceived autonomy as an outcome produced through economic and institutional arrangements rather than solely through individual will. While existing literature has extensively …


Helping The Whole Heart, Aashna A. Shah Jan 2026

Helping The Whole Heart, Aashna A. Shah

High Impact Practices Student Showcase Spring 2026

My service-learning project, “Helping the Whole Heart,” focuses on my second semester volunteering with Shepherd’s Hope, a nonprofit organization that provides free healthcare to uninsured and underinsured adults in Central Florida. The purpose of my project was to support the clinic while learning more about healthcare access, service, and community responsibility. During my shifts, I helped greet patients, check them in, prepare charts, organize paperwork, and assist the clinic team wherever I was needed. Through this experience, I learned that healthcare is about more than just medical treatment. It is also about patience, communication, compassion, and making patients feel respected. …


Eve's Apple, Deiadra Elliott Jan 2026

Eve's Apple, Deiadra Elliott

High Impact Practices Student Showcase Spring 2026

For our final project, we were asked to create or rewrite a fairy tale with a contemporary teenage audience in mind. We had to include gender studies, feminist theory or an approved theory of our own in our work. I chose to rewrite the fairy tale Snow White expanding on the religious themes included in the original work, for a darker, more gruesome tale that teenagers might enjoy. In my research so far, I more about the brothers Grimm and the background surrounding the Grimm's fairy tales. I learned about 19th century Germany, as well as the balance the country …


The Strength Of The Association Between Obesity And Mortality From Diabetes Among Adults In Florida, Diego A. Garcia, Jacob Bleasdale Phd,Ms,Ches, Cristobal Cintron Msc, Drph Jan 2026

The Strength Of The Association Between Obesity And Mortality From Diabetes Among Adults In Florida, Diego A. Garcia, Jacob Bleasdale Phd,Ms,Ches, Cristobal Cintron Msc, Drph

High Impact Practices Student Showcase Spring 2026

Background: Diabetes mellitus is a leading cause of preventable death across the United States, with obesity being directly tied to this condition as one of its most significant and modifiable risk factors. Although national-level evidence strongly supports this association, Florida-specific population data is still limited.

Methods: County-level adult obesity prevalence and age-adjusted diabetes mortality data were obtained directly from the Florida Health CHARTS website (FL DOH,2024) for all Florida counties. The Pearson correlation (r) was used to evaluate the strength of association between the variables

Results: A statistically significant, moderate-positive correlation was found between adult obesity rates …


Tracing Evolution Through Teeth: Dental Morphology Of The Lagoa Santa Fossil Population, Kelsey Aaron Jan 2026

Tracing Evolution Through Teeth: Dental Morphology Of The Lagoa Santa Fossil Population, Kelsey Aaron

High Impact Practices Student Showcase Spring 2026

This study examines dental morphological variation among early South American populations, focusing on individuals from the Lagoa Santa region and coastal shellmound (sambaqui) populations in Brazil. Dental nonmetric traits were recorded using the Arizona State University Dental Anthropology System (ASUDAS), a standardized method for assessing crown and root morphology across populations (Qaqa et al., 2026). These traits are highly heritable and largely unaffected by environmental pressures, making them valuable for reconstructing population history, gene flow, and ancestry (Tinoco et al., 2016). Comparative analysis incorporates global dental variation and reference patterns associated with archaic hominins, including Neanderthals. Traits such as increased …


Analyzing The Impact Of Ai Tool Type And Work Environment On Employee Productivity: A Multiple Linear Regression Analysis​, Katrina Gumerov, Alex Weninski, Victor Aviles Jan 2026

Analyzing The Impact Of Ai Tool Type And Work Environment On Employee Productivity: A Multiple Linear Regression Analysis​, Katrina Gumerov, Alex Weninski, Victor Aviles

High Impact Practices Student Showcase Spring 2026

An assessment has been conducted to see how much AI tools and workplace conditions affect productivity using a multiple linear regression approach. This project looked at how different kinds of AI tools affect performance, as well as other things like commute time to work, employee well-being, and hours worked. The dataset was cleaned and restructured, and then the various AI tools were grouped into meaningful categories. After grouping the tools, an exploratory data analysis was conducted to look for trends. Finally, models were developed using multiple linear regression. For model selection, forward, backward, and stepwise model selection methods were used …


Drained Defenses: How Altered Hydrology Influences Invasive Plant Species Richness In Cypress Domes, Jamie M. Snider, Cori Mcwilliams, Natalia Knapp-Seale, Deborah Faerman Jan 2026

Drained Defenses: How Altered Hydrology Influences Invasive Plant Species Richness In Cypress Domes, Jamie M. Snider, Cori Mcwilliams, Natalia Knapp-Seale, Deborah Faerman

High Impact Practices Student Showcase Spring 2026

Cypress domes are unique wetland ecosystems distinct in species biodiversity and hydrologic patterns which have become increasingly degraded from alteration of hydrology. These changes are made with little understanding about how this may affect plant communities and weaken a wetland’s resistance to invasive species, shifting its plant regimes. This study investigates how altered hydrology affects the presence of invasive species and may cause plant communities to shift by studying two cypress domes on UCF campus. Three 30 meter transects were established per wetland in random cardinal directions, with 70 cm quadrats placed every 6 meters for a total of 18 …


Analysis Of Azithromycin-Prevention In Labor Use Study, Emily Martinez, Roldine Questel, Willow Baldwin, Emma Coffman Jan 2026

Analysis Of Azithromycin-Prevention In Labor Use Study, Emily Martinez, Roldine Questel, Willow Baldwin, Emma Coffman

High Impact Practices Student Showcase Spring 2026

This group project was developed for the Health Sciences Seminar course. The purpose of this project was to analyze a clinical trial which evaluated the effectiveness of azithromycin in preventing pregnancy-related maternal sepsis or death. Azithromycin is a commonly prescribed, broad-spectrum oral antibiotic that is inexpensive and widely accessible; It has antibacterial and anti-inflammatory properties and may help prevent infection when used prophylactically. The study’s primary measurable outcomes were instances of maternal and neonatal death or sepsis within 6 weeks (42 days) postpartum. Based on the results, azithromycin was effective in preventing instances of sepsis maternally, but not within neonates. …


Coalition For The Homeless Of Central Florida Culture Audit, Daniel S. Torres, Ayushi Goswami, Emannuele Louis Jean, Logan Thompson, James Magdeburg Jan 2026

Coalition For The Homeless Of Central Florida Culture Audit, Daniel S. Torres, Ayushi Goswami, Emannuele Louis Jean, Logan Thompson, James Magdeburg

High Impact Practices Student Showcase Spring 2026

The project we did was a culture audit that evaluated the strength of the organization that is the Coalition for the Homeless of Central Florida. We were able to learn about the way they lead and connect it to the leadership course we were taking. This whether it be through service or speaking to staff and the public, we were able to understand the way an organization could function. The coalition functions as an organization that prioritizes servitude to the public and relational ideals in between the staff. They also match what they say in both their mission and vission.


Women In Industrial Engineering Leadership And Barriers To Advancement, Fiorella Barney Jan 2026

Women In Industrial Engineering Leadership And Barriers To Advancement, Fiorella Barney

High Impact Practices Student Showcase Spring 2026

This research investigates how organizational and cultural barriers influence the advancement of women into leadership positions within industrial engineering. Despite being one of the more gender-balanced engineering disciplines at the entry level, industrial engineering remains largely male-dominated in leadership, and this project set out to understand why that gap persists and what sustains it.

To explore this question, I conducted a review of seven peer-reviewed sources organized around five themes: the scope of underrepresentation, organizational barriers, gendered workplace culture, early career pipeline effects, and attrition. I then conducted a qualitative, semi-structured interview with a woman who began her career as …


Analysis Of Workplace Attributes On Annual Income In The Technology Sector, Kyle J. Miller, Naddya Jannessa Favela, Kyle A. Carter Jan 2026

Analysis Of Workplace Attributes On Annual Income In The Technology Sector, Kyle J. Miller, Naddya Jannessa Favela, Kyle A. Carter

High Impact Practices Student Showcase Spring 2026

No abstract provided.


Effects Of Kratom Mixture On Cell Death In Cos-7 Cells Using Immunofluorescence, Hoa A. Nguyen Jan 2026

Effects Of Kratom Mixture On Cell Death In Cos-7 Cells Using Immunofluorescence, Hoa A. Nguyen

High Impact Practices Student Showcase Spring 2026

The purpose of this project was to visualize the cellular impact of Kratom (Mitragyna speciosa), a supplement commonly utilized for pain management and opioid withdrawal. The project investigated the effects of a 5% Kratom mixture on COS-7 monkey kidney cells. By using immunofluorescence, the cytoskeleton could be observed, and we can determine if Kratom could result in cellular failure.

In the immunofluorescence protocol, the cells were fixed in a methanol based solution to preserve position, while also permeabilizing the membranes with Triton X-100, and applying specific fluorophores. We used indirect staining for Tubulin (Red, Goat anti-mouse 568), direct staining for …


How Do The Interrogation Strategies Of Women Detectives Differ In Style And Efficacy From Their Male Counterparts?, Sarah M. Quinones Jan 2026

How Do The Interrogation Strategies Of Women Detectives Differ In Style And Efficacy From Their Male Counterparts?, Sarah M. Quinones

High Impact Practices Student Showcase Spring 2026

This research proposal seeks to examine recorded interrogation footage and in-depth interviews of professional interrogators to analyze how their interrogation styles and efficacies differ between men and women. There is an imminent need for a reformed, standardized, and research-backed interrogation system to improve the efficacy and discriminatory habits of the justice system. The proposed hypotheses include:

  • Transformational interrogation styles yield more cooperative and informative responses than transactional interrogation styles. 

  • Because women’s interrogation styles more often align with transformational leadership patterns, their interrogations exhibit higher efficacies.

These hypotheses were drawn following an extensive literature review of the current academic contributions, both …


Examining Patient Safety Culture Trends In U.S. Healthcare Through A Multi-Year Analysis, Hassan Alabdullah Jan 2026

Examining Patient Safety Culture Trends In U.S. Healthcare Through A Multi-Year Analysis, Hassan Alabdullah

Graduate Studies Theses and Dissertations 2026

Patient Safety Culture (PSC) is recognized as a cornerstone of healthcare quality and a key determinant of patient outcomes. Despite the Institute of Medicine’s early calls to establish safety-oriented systems, evidence on the long-term stability of PSC in U.S. hospitals has remained limited. This dissertation addresses this gap through a multi-year evaluation of PSC using the Hospital Survey on Patient Safety Culture (HSOPSC v1.0) and advanced statistical methods. Drawing on one of the largest national datasets—comprising over 993,000 healthcare providers from 1,601 U.S. hospitals across three survey cycles (2013–2020)—the study employed a longitudinal repeated cross-sectional design. Analyses combined descriptive statistics, …


Impact Of Prostate Cancer Tumor Microenvironment On Alternative Splicing Landscapes In Nk Cells: An Lncap-Based In Vitro Model, Pratham N. Modi Jan 2026

Impact Of Prostate Cancer Tumor Microenvironment On Alternative Splicing Landscapes In Nk Cells: An Lncap-Based In Vitro Model, Pratham N. Modi

Honors Undergraduate Theses

NK cells play a significant role in anti-tumor activity, yet the transcriptomic mechanisms underlying NK cell dysfunction in the prostate cancer tumor microenvironment remain generally poorly characterized. While most transcriptomic studies focus on gene-level expression, alternative splicing and isoform-level analysis may reveal additional levels of regulation not identified in traditional analysis. The overall goal of this study was to characterize gene and isoform-level changes in NK cells exposed to in vitro prostate cancer conditions and to evaluate whether isoform-level analysis could provide additional depth and insights beyond gene-level analyses. NK92-MI cells were co-cultured with LNCaP prostate cancer cells using direct-contact …


Casual And Confused: Engagement In Non-Committal Sexual Relationships And Its Contributions To Depression And Self-Esteem Struggles Among Young Adults, Sofia A. Marasco Jan 2026

Casual And Confused: Engagement In Non-Committal Sexual Relationships And Its Contributions To Depression And Self-Esteem Struggles Among Young Adults, Sofia A. Marasco

Honors Undergraduate Theses

Non-committal sexual relationships such as hook-ups, friends-with-benefits (FWB/FWBR), and situationships have become increasingly common among young adults and have generated substantial discourse on social media. Despite the rise in modern relationship dynamics and new terminology (i.e., “situationships”), these relationship categories have not been adequately represented in psychological research. The present study examines whether engagement in non-committal relationship types is associated with differences in self-esteem and depressive symptoms compared to committed romantic relationships. Using Bowlby’s Attachment Theory and the Big Five Personality Model, this research also explores whether common interpersonal patterns, attachment styles (anxious and avoidant), and personality traits predict relationship …


Variability In Parainfluenza Virus Derived From Persistently Infected Lung Epithelial Cells, Cassidy R. Conte Jan 2026

Variability In Parainfluenza Virus Derived From Persistently Infected Lung Epithelial Cells, Cassidy R. Conte

Honors Undergraduate Theses

An acute infection (AI) with RNA virus can progress to a persistent infection (PI) where infected cells continue to grow and replicate while producing progeny virions. PIs with respiratory viruses are clinically important, as they can lead to prolonged shedding of viruses and generation of mutant viruses that are altered in pathogenesis and/or immune responses. Parainfluenza type 5 (PIV5) is a prototypic RNA virus shown to cause PIs in cell culture. Plaques in tissue culture from an acute infection with parental PIV5 were homogeneous in size and shape. By contrast, plaques from PIV5 persistently infected cells were heterogeneous, having a …


Artificial Elections: How Artificial Intelligence Can Affect Elections And Decide Our Future, Ryan D. Granger Jan 2026

Artificial Elections: How Artificial Intelligence Can Affect Elections And Decide Our Future, Ryan D. Granger

Honors Undergraduate Theses

This thesis examines the growing role of artificial intelligence (AI) in democratic elections, highlighting both its transformative potential and its associated risks. Drawing on a qualitative analysis of existing literature, the study explores how AI is increasingly integrated into political campaigns, election administration, and voter engagement. Key benefits include enhanced data analysis, personalized political messaging, and improved efficiency in campaign operations. AI also supports real-time fact-checking and more accurate vote tabulation, which can strengthen transparency and trust in electoral processes. However, the thesis emphasizes that these advantages are accompanied by significant challenges. AI technologies enable the rapid creation and dissemination …


Regulation Of The Low-Density Lipoprotein Receptor In A Colon Cancer Cell Line By The Prostasin Serine Protease, Juan Pablo Ruiz Jan 2026

Regulation Of The Low-Density Lipoprotein Receptor In A Colon Cancer Cell Line By The Prostasin Serine Protease, Juan Pablo Ruiz

Honors Undergraduate Theses

In the effort to combat hypercholesterolemia and cardiovascular disease, research has turned to studying the effects of serine proteases on the low-density lipoprotein receptor (LDLR), which plays a key role in the diseased states with high LDL levels. Matriptase has been shown to proteolytically shed the extracellular domain (ECD) of the LDLR in the co-translational setting. Prostasin (PRSS8) and matriptase (ST14) are part of a proteolytic activation cascade and it is hypothesized that the coactivation of prostasin and matriptase or a pharmacological perturbation of the steady state could result in LDLR ECD shedding in cells co-expressing the receptor and the …


Comparative Spatial Biology: A Cross-Species Analysis Of Canine Oral Cancers As Models For Human Disease, Ram Pradhyumnan Jan 2026

Comparative Spatial Biology: A Cross-Species Analysis Of Canine Oral Cancers As Models For Human Disease, Ram Pradhyumnan

Honors Undergraduate Theses

Oral squamous cell carcinoma (OSCC), one of the most common malignancies of the oral cavity, remains a clinically challenging disease due to its aggressive behavior, late-stage diagnosis, and limited improvements in therapeutic outcomes over recent decades. A significant barrier to progress in OSCC research and treatment is the lack of suitable preclinical models that recapitulate the complexity and natural progression of the disease. Most current models—including cell lines, xenografts, and genetically engineered mice—fail to capture key features such as the spatial organization of tumor epithelium, interactions with an intact immune system, and the stepwise evolution from normal mucosa to invasive …