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Deciphering The Role And Clinical Application Of The Fgfr4-Klb-Fgf19 Axis In Colorectal Neoplastic Progression, Michael Rohr Jan 2022

Deciphering The Role And Clinical Application Of The Fgfr4-Klb-Fgf19 Axis In Colorectal Neoplastic Progression, Michael Rohr

Electronic Theses and Dissertations, 2020-2023

Colorectal cancer (CRC) is the third most common and third deadliest cancer worldwide with rising incidence rates attributed to environmental risk factors like diet. Investigating how these factors impact carcinogenesis requires an understanding of how transcriptional events evolve with respect to neoplastic progression. We employed meta-transcriptomics and latent trajectory modeling to establish a compendium of profiled healthy, adenoma, and CRC samples scored by their position along a pseudotemporal axis. By interpolating a continuous scale from cross-sectional data, dynamic processes occurring throughout disease progression can be analyzed more accurately. For example, smaller pseudotimes represented pre-malignant dysplasia and was characterized by cellular …

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Generic Behavior Framework Of Sx And Ds Nickel-Base Superalloys With Applications To Constitutive And Life Prediction Modeling, Firat Irmak Jan 2022

Generic Behavior Framework Of Sx And Ds Nickel-Base Superalloys With Applications To Constitutive And Life Prediction Modeling, Firat Irmak

Electronic Theses and Dissertations, 2020-2023

Selection of materials to be used for components experiencing extreme conditions is a critical process in the design phase. Nickel-base superalloys have been frequently used for hot gas path components in the turbomachinery industry. These components are required to withstand both fatigue and creep at extreme temperatures during their service time. In general, the extreme temperature materials mostly embody polycrystalline, directionally solidified, and single crystal superalloys. It is essential for design engineers to predict accurate damage behavior and lifespan for these components to prevent catastrophic failures. This dissertation presents a new framework to represent mechanical behavior of Nickel-base superalloys under …

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A Survival Analysis Examining Risk And Protective Factors Of Foster Care Reentry For Children Aged 0 To 5 Within A Social Ecological Framework, Samantha Klaver Jan 2022

A Survival Analysis Examining Risk And Protective Factors Of Foster Care Reentry For Children Aged 0 To 5 Within A Social Ecological Framework, Samantha Klaver

Electronic Theses and Dissertations, 2020-2023

Although the fundamental goals of the child welfare system include establishing and ensuring the safety, permanency, and well-being of affected children, child reentry into the foster care system has emerged recently as a substantial and growing concern (Jedwab & Shaw, 2017). Utilizing archival, statewide administrative data collected from Florida's Department of Children and Families (DCF), a series of multivariate Cox regression models were conducted on a sample of young children between the ages of 0- and 5-years (N = 3,970) to examine various socioecological risk and protective factors of foster care reentry. Several individual factors (i.e., child age at initial …

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The Sociology Of God: The Case Of Homeless Believers, John L'Hommedieu Jan 2022

The Sociology Of God: The Case Of Homeless Believers, John L'Hommedieu

Electronic Theses and Dissertations, 2020-2023

This research began as personal curiosity about the religious beliefs of persons experiencing homelessness, and in particular their beliefs about God. What do they believe about God, and how are their beliefs socially constructed? Social research has generally limited its focus to assessing religion as an asset in ameliorating homelessness as a social problem with little attention to the religious behaviors and thought processes of persons experiencing homelessness themselves. I conducted a classic grounded theory (CGT) analysis based on 14 in-depth interviews with homeless believers (HB's) and three interviews with pastors-service-providers (PSP's) for comparative analysis. The findings include two major …

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Innovation Resistance? Understanding Officer Attitudes Toward Police Innovation, Justin Smith Jan 2022

Innovation Resistance? Understanding Officer Attitudes Toward Police Innovation, Justin Smith

Electronic Theses and Dissertations, 2020-2023

Over the years, innovations such as community-oriented policing, problem-oriented policing, and crime analysis have helped police agencies control, reduce, and prevent crime and disorder, and improve police and community relations. However, research shows that some officers are resistant to using these innovations in practice. Few studies have examined the causal mechanisms behind innovation resistance. This doctoral dissertation details a study that utilized a mixed method approach to partially test a framework that encompassed two theories to explain officer resistance to innovation: The Model of Consumer Resistance to Innovation from the consumer psychology and marketing fields (Ram & Sheth, 1989), and …

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Employing A Network Perspective To Study Hazardous Events In Tourism: Tourism Connections, Island Preferences, And Tourism Market Concentrations In The Hawaiian Islands (2015-2021), Frida Bahja Jan 2022

Employing A Network Perspective To Study Hazardous Events In Tourism: Tourism Connections, Island Preferences, And Tourism Market Concentrations In The Hawaiian Islands (2015-2021), Frida Bahja

Electronic Theses and Dissertations, 2020-2023

The purpose of this study was to employ a network perspective to detect fluctuations in tourism (at the level of tourism areas and by inbound tourism markets) that co-occur with hazardous events. Specifically, the study focuses on the Air Travel Tourism (ATT) network of the Hawaiian Islands and its changes with the incidence of nine hazardous events from 2015 to 2021. The three main aspects of the ATT network, which include tourism connections, island preferences, and concentrations of inbound tourism markets were analyzed for a total of eighty-four monthly and seven annual network models. The results suggest that the network …

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Design And Mechanical Characterization Of Functionally Graded Sandwich Beams Fabricated Via Additive Manufacturing, Timothy Grondin Jan 2022

Design And Mechanical Characterization Of Functionally Graded Sandwich Beams Fabricated Via Additive Manufacturing, Timothy Grondin

Electronic Theses and Dissertations, 2020-2023

Lightweight aerospace structures have been sought after since humans took flight in 1903, making major strides in NASA's pursuit of the moon with the development of sandwich panel composites. Sandwich structures typically consist of two stiff phases (i.e., face sheets) separated by a lightweight phase (i.e., core), which are stacked together through adhesive layers. Such a structural arrangement provides a high stiffness-to-weight ratio and is often used in applications where weight saving is critical. Functionally Graded Materials (FGMs), refer to multifunctional materials, which contain a spatial variation of composition and/or microstructure for the specific purpose of altering thermal and structural …

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Reporter Chondrocyte Optimization Of Bioinks For Zonal 3d Bioprinting Of Cartilage, Kari Martyniak Jan 2022

Reporter Chondrocyte Optimization Of Bioinks For Zonal 3d Bioprinting Of Cartilage, Kari Martyniak

Electronic Theses and Dissertations, 2020-2023

Osteoarthritis (OA) is the most common form of arthritis, often thought of as a disease of the elderly, but post traumatic OA predominantly impacts younger individuals. Articular cartilage is the tissue that coats the end of your bones in synovial joints. Since cartilage has limited healing capacity, defects, or injuries to it progressively erodes down to the subchondral bone. Unfortunately, current treatment options all have limitations, particularly for younger patients. Cartilage has a specific zonal architecture that is distinguished by the different cell morphologies and arrangements, biochemical composition, and mechanical properties. 3D bioprinting is a tissue engineering technique that involves …

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Igniting Interest?: Female Perceptions Of Communication Effectiveness In Public Safety Recruitment Campaigns, Ashley Papagni Jan 2022

Igniting Interest?: Female Perceptions Of Communication Effectiveness In Public Safety Recruitment Campaigns, Ashley Papagni

Electronic Theses and Dissertations, 2020-2023

Despite the potential for positive impacts resulting from a diverse workforce, fire departments across the country have struggled with the recruitment and hiring of minorities for decades, with women accounting for only 4.7% of its workforce (NFPA, 2020). Due in part to the limited diversity, the fire service tends to perpetuate the stereotypes of masculinity. There are three identified issues that are leading to the lack of female applicants in public safety positions, including the lack of diversity and inclusivity in Public Safety Organizations (PSOs), the absence of women in the role as firefighters, and the absence of recruitment strategies …

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The Antecedents Of Program Satisfaction And Program Loyalty For Hotel Reward Programs, Jill Plumer Jan 2022

The Antecedents Of Program Satisfaction And Program Loyalty For Hotel Reward Programs, Jill Plumer

Electronic Theses and Dissertations, 2020-2023

Hotel reward programs have been in existence for three decades. These programs were originally established as a customer relationship management tool to reward loyal guests for their patronage. Over time, there have been indications that the programs that are intended to inspire loyalty to the company have actually inspired loyalty to the program itself. The aim of this study was to analyze the antecedents of program satisfaction and program loyalty in hotels to determine the relationship between the program attributes and the impact on program loyalty. Switching costs were also analyzed to determine if they played a moderating role in …

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The Effect Of Heat Transfer On Microstructural Development For Inconel718 Nickel-Based Superalloy In Laser Powder Bed Fusion, Erica Drobner Jan 2022

The Effect Of Heat Transfer On Microstructural Development For Inconel718 Nickel-Based Superalloy In Laser Powder Bed Fusion, Erica Drobner

Electronic Theses and Dissertations, 2020-2023

Inconel 718 (IN718) is a superalloy with excellent corrosion resistance and high temperature stability, giving rise to its popular use in the aerospace industry as well as other high performing applications. This study utilizes the relatively low conductivity of IN718 to focus in on the heat transfer procedures in which occur during the laser powder bed fusion (LPBF) manufacturing process of metals. Cylindrical samples of constant geometry with varying dimensions of thermal supports were fabricated using a compatible IN718 build plate. As thermal support size increased, heat dissipation to the build plate consequently increased. Theoretically, this modification of heat transfer …

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Law Enforcement Motivations For Establishing Real-Time Crime Centers: A Mixed Model Study, Frank Linton Jan 2022

Law Enforcement Motivations For Establishing Real-Time Crime Centers: A Mixed Model Study, Frank Linton

Electronic Theses and Dissertations, 2020-2023

Law enforcement agencies across the United States are establishing real-time crime centers (RTCCs) at a rapid rate, yet research exploring the decisions to establish them is lacking. This study therefore attempts to fill that void by using a mixed methods approach to examine whether adaptive organizational theories, consisting of contingency theory (Lawrence & Lorsch, 1967; Woodward, 1965), resource dependency theory (Pfeffer & Salancik, 1978), and institutional theory (DiMaggio & Powell 1991; Meyer & Rowan, 1977), can be used to explain a law enforcement agency's decision to set up an RTCC. This cross-sectional mixed methods design comprised two different studies (Study …

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White Rage, Black Agency: Violence And Its Impact On Reconstruction Era Florida, Zachary Barnes Jan 2022

White Rage, Black Agency: Violence And Its Impact On Reconstruction Era Florida, Zachary Barnes

Electronic Theses and Dissertations, 2020-2023

The Reconstruction era in Florida is often misunderstood. Historians generally focus on the Civil War and the post-Reconstruction era to emphasize how the South has changed, but the Reconstruction era remains in shadow. To rectify this gap, this research provides more information about the Reconstruction era in Florida, specifically the impact of violence. To achieve this, I primarily used the testimonies gathered from the Joint Select Committee's investigation of violence during the Reconstruction era and the testimonies given to the Federal Government after the 1876 Presidential Election. The testimonies in these documents allow me to demonstrate how conservative whites used …

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National Identity And Civil War Memory In The American South: How History, Ideology, And Media Inform The Culture Wars Of The Late Twentieth Century, John Lancaster Jan 2022

National Identity And Civil War Memory In The American South: How History, Ideology, And Media Inform The Culture Wars Of The Late Twentieth Century, John Lancaster

Electronic Theses and Dissertations, 2020-2023

On Veterans Day weekend, 1994, the remains of a Confederate soldier named Lewis Powell were reinterred in a cemetery in Geneva, Florida and given military honors. This thesis begins by historicizing Powell's burial ceremony to the final decades of the twentieth century to argue for new ways of viewing and understanding how Americans engaged with Civil War memory and legacy at a time of particularly felt social and cultural change. The 'culture wars' of the 1980s and 1990s describe the many battles and debates fought over issues as wide-ranging as race, politics, gender, sexuality, religion, and education, and were often …

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Graph Neural Networks For Improved Interpretability And Efficiency, Patrick Pho Jan 2022

Graph Neural Networks For Improved Interpretability And Efficiency, Patrick Pho

Electronic Theses and Dissertations, 2020-2023

Attributed graph is a powerful tool to model real-life systems which exist in many domains such as social science, biology, e-commerce, etc. The behaviors of those systems are mostly defined by or dependent on their corresponding network structures. Graph analysis has become an important line of research due to the rapid integration of such systems into every aspect of human life and the profound impact they have on human behaviors. Graph structured data contains a rich amount of information from the network connectivity and the supplementary input features of nodes. Machine learning algorithms or traditional network science tools have limitation …

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Utilizing Geographic Information Systems To Explore The Mortuary Landscape At Kuelap, Peru, Hannah Haynes Jan 2022

Utilizing Geographic Information Systems To Explore The Mortuary Landscape At Kuelap, Peru, Hannah Haynes

Electronic Theses and Dissertations, 2020-2023

The placement of the dead is important for considering social memory, a source of collective knowledge and experiences that shapes social group identity. Mortuary placement is one form of ritual action that communities undertake to remember the dead. This allows anthropologists to ask questions about how humans engaged socially with each other and the landscape. This thesis utilizes an innovative methodological approach combining geographic information systems (GIS) and stable carbon and nitrogen isotope analysis to investigate mortuary variation and social identity within the Late Intermediate Period site (A.D. 800 – 1535) Kuelap in the northern Peruvian Andes. Spatial, demographic, and …

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Computational Modeling Of Respiratory Airflow In Human Distal Airways Using Hybrid Lung Model, Adnan Islam Jan 2022

Computational Modeling Of Respiratory Airflow In Human Distal Airways Using Hybrid Lung Model, Adnan Islam

Electronic Theses and Dissertations, 2020-2023

A major challenge in the Computational Fluid Dynamics (CFD) modeling of the human respiratory system is the complex variation of geometric scale from the trachea to the peripheral airways. The current literature on image-based lung flow analysis is limited to a few (typically 5) generations beyond the trachea. Such studies, which are limited largely by computational intensity and computational cost, also have limited accuracy. In this study we propose a hybrid methodology that enables CFD analysis from the middle to the distal airways through to the alveolar level. A hybrid lung model is generated where the middle airways are reconstructed …

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Decentralization And Violence, Alexander Norat Jan 2022

Decentralization And Violence, Alexander Norat

Electronic Theses and Dissertations, 2020-2023

How does the political environment that a group operates affect whether they engage in terrorism? My research is concerned with how political opportunities, which I conceptualize in terms of political decentralization, affect how groups engage with the state, and whether they will engage in terrorism. Previous research has indicated that decentralization can reduce violence but can pose stability problems in other countries. I hypothesize that states with higher levels of decentralization will have lower levels of violence. I believe this works by allowing minority groups more access to power. Because they have access to political power, there is less incentive …

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Eco-Tya: An Exploration Of Youth Agency And The Role Of Environment In Creating Balanced Theatrical Collaborations, Sage Tokach Jan 2022

Eco-Tya: An Exploration Of Youth Agency And The Role Of Environment In Creating Balanced Theatrical Collaborations, Sage Tokach

Electronic Theses and Dissertations, 2020-2023

Systems of power in traditional theatrical and educational models may lead to controlled, efficient classrooms, but they do not help us facilitate creative, collaborative spaces. These power structures privilege some people over others and all people over environmental concerns. Eco-theatre artists emphasize the agency of more-than-human materials and encourage us to see our environment as a collaborator. Using eco-theatre theories in a synthesized methodology, this thesis explores how facilitators might interact differently with students and surroundings to disrupt power structures and lead to more inclusive collaborations. What tools and practices help students embrace challenges and work through tensions on their …

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Social Complexity And Water Management Strategies At Holtun, Guatemala, Melvin Rodrigo Guzman Piedrasanta Jan 2022

Social Complexity And Water Management Strategies At Holtun, Guatemala, Melvin Rodrigo Guzman Piedrasanta

Electronic Theses and Dissertations, 2020-2023

Water management strategies are intrinsically associated with the development of complex societies. Traditional approaches have often characterized these strategies as homogenous and monolithic. Recent studies have shown that water management among the ancient Maya was a significant source of power, but the strategies implemented, and the outcomes are highly variable and dependent on the landscape. The case of Holtun, a modest-sized site, adds to the growing body of water management research in ancient Maya archaeology as most water management systems are investigated in large primary centers. Although water resources at Holtun are relatively small, they supported large communities during the …

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Journey To The Dragon's Gate: A Study Of Hybrid Ride Systems And How They Enhance Attraction Storytelling, Matthew Moore Jan 2022

Journey To The Dragon's Gate: A Study Of Hybrid Ride Systems And How They Enhance Attraction Storytelling, Matthew Moore

Electronic Theses and Dissertations, 2020-2023

The purpose of this thesis is to explore a new type of ride design which integrates one or more transitions between formats. Theme Park visitors have come to expect a certain type of immersive experience from attractions. Most rides in the parks are very predictable such as roller coasters which offer loops, drops, speed and quick turns, while dark rides offer a slower pace with the attention on storytelling. The solution to this situation is to combine two ride systems or more into a single ride. The ride system for my attraction begins with a free-floating boat ride navigating its …

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Theme Park Queues As Diegetic Worlds: Using Star Wars: Rise Of The Resistance As A Case Study For Core Design Elements, Jordan Zauha Jan 2022

Theme Park Queues As Diegetic Worlds: Using Star Wars: Rise Of The Resistance As A Case Study For Core Design Elements, Jordan Zauha

Electronic Theses and Dissertations, 2020-2023

This thesis seeks to establish core design elements for use by theme park designers to complement the guidelines established by Ledbetter and his colleagues for theme parks. Building upon Rose Biggin's "strands of enquiry" for examining immersive theatre, the suggested core design elements for immersive theme park queues serve as guidance to craft queues where audiences can actively engage with the queue's storyworld and narrative. Implementation of the core design elements alongside the already established queue design guidelines should assist designers in crafting queues that minimize discomfort and maximize narrative immersion. Theme parks offer location-based narrative landscapes, often contributing to …

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Volume Xxiv (2021-2022) Jan 2022

Volume Xxiv (2021-2022)

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

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Genomic Analysis Of Pollen Grains For Forensic Applications, Luz Kelley Jan 2022

Genomic Analysis Of Pollen Grains For Forensic Applications, Luz Kelley

Electronic Theses and Dissertations, 2020-2023

With over 300,000 plant species on the planet and more than 90% of them relying on pollen for reproduction, palynology, the study of pollen grains plays a vital role in many research fields. One of them is forensic palynology, which uses pollen as a proxy to link individuals or objects to a location or instance. It relies on the fact that (1) pollen is an ever-present feature of the environment; (2) different locations have different pollen signatures, allowing for inference related to spatial tracking; (3) plants bloom at different times, allowing for temporal inference; and (4) pollen is exceptionally durable …

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Patient Perceptions Of Shared Decision-Making In The Acute Care Hospital And Their Association With Patient Experience And Readmission, Jill Haladay Jan 2022

Patient Perceptions Of Shared Decision-Making In The Acute Care Hospital And Their Association With Patient Experience And Readmission, Jill Haladay

Electronic Theses and Dissertations, 2020-2023

Avoidable hospital readmissions continue to be a concerning and costly healthcare issue. While the emphasis on reducing avoidable hospital readmissions persists, incentivization strategies are evolving. Initial strategies prioritized medical care delivery, but recent regulation highlights the value of effective transitional (discharge) care planning, and particularly, patient involvement in that process. This latter aspect of care has a clear indication for the application of shared decision-making. Shared decision-making (SDM) practice in the acute care setting largely represents a gap in the literature; yet understanding patient perceptions of SDM during hospitalization is an important and timely first step in exploring the effectiveness …

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An Examination Of Street-Level Drug Enforcement Tactics And Court Outcomes, Nicholas Paul Jan 2022

An Examination Of Street-Level Drug Enforcement Tactics And Court Outcomes, Nicholas Paul

Electronic Theses and Dissertations, 2020-2023

While there is a substantial body of placed-based evaluations of drug enforcement strategies, little is known about the nature and effectiveness of the routine tactics used by local police to target individual drug offenders. This study used a mixed-method approach to build on existing research on the efficacy of drug enforcement by documenting the nature and consequences of street-level drug enforcement at the local level. First, a focus group of drug enforcement experts was conducted to identify the tactics used to generate arrests and various types of evidence believed to strengthen drug cases. Next, official data in the form of …

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"How To Succeed": Determining And Comparing The Musical And Non-Musical Influences Behind The Broadway Adaptation Of How To Succeed In Business Without Really Trying, Gary Bogers Jan 2022

"How To Succeed": Determining And Comparing The Musical And Non-Musical Influences Behind The Broadway Adaptation Of How To Succeed In Business Without Really Trying, Gary Bogers

Electronic Theses and Dissertations, 2020-2023

The following research project is the result of comparing and contextualizing the original non-musical and musical drafts of the original 1961 Broadway production of How to Succeed in Business without Really Trying. The intention is to detail the process of musically adapting a non-musical source, specifically the 1952 satirical text How to Succeed in Business without Really Trying: The Dastard's Guide to Fame and Fortune by businessman-turned-satirist Shepherd Mead. Research was predominantly completed through analysis of the non-musical draft written by television writers Jack Weinstock and Willie Gilbert in the 1950s and acquired from the Billy Rose Theatre Division of …

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Musicals, Murders, And Motivation: A View On The Audience And Their Support Towards Musical Murderers Through Maslow, Lesly Nuñez Jan 2022

Musicals, Murders, And Motivation: A View On The Audience And Their Support Towards Musical Murderers Through Maslow, Lesly Nuñez

Electronic Theses and Dissertations, 2020-2023

Audiences relay morbid support towards the enjoyment of horrific entertainment. Such examples are the success and long-standing allure spectators hold towards musicals such as Phantom of the Opera, Spring Awakening, Heathers, and more. These are shows that include themes of death, darkness, and tragedy which are presented. Using Abraham Maslow's Hierarchy of Needs and Motivation, The Jungian Archetype of Shadow, and Catharsis I will show how audiences are supportive of protagonists who portray actions resulting in death, darkness, and murder despite the societal pressure to find such subject matter as offensive, vile, repugnant, or obscene. By referencing the characters found …

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The Impact Of Social Capital On U.S. Based Destination Marketing Organizations And Interorganizational Relationships, Jeremy Fairley Jan 2022

The Impact Of Social Capital On U.S. Based Destination Marketing Organizations And Interorganizational Relationships, Jeremy Fairley

Electronic Theses and Dissertations, 2020-2023

Previous literature echoes the notion that destination marketing organizations (DMOs) play a critical role in ensuring a desired tourism development scenario. To date, the performance measurement of destination marketing organizations is paralleled to financial indicators or operations, ignoring the presence and quality of relationships among DMOs and tourism stakeholders. Based on the premise of social capital theory, it is argued that social capital and the inter-organizational relationships between DMOs and tourism stakeholders can influence the success of tourism efforts in a destination, which in return is a contributing factor to the DMOs success as an organization. Furthermore, broader literature indicates …

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Index To Volume Lxv, Florida Historical Society Dec 2021

Index To Volume Lxv, Florida Historical Society

Florida Historical Quarterly

No abstract provided.

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