Digital Commons Network^™

Ivermectin On Twitter: Investigating Early Advocacy For Covid-19 Vaccine Alternatives, Daniel Gabriel

Honors Undergraduate Theses

An emerging pattern of public doubt in scientific and political authorities has been seen during the COVID-19 pandemic, where numerous alternatives to vaccinations have gone viral. Ivermectin's growth from a relatively known specialist drug to a political controversy is a striking example of the amplification that social media can provide. Doubt in the dangers of illness has occurred in regard to previous diseases with limited impact, including the Zika virus, Ebola, and H1N1. However, the COVID-19 pandemic's impact in the United States is a much larger example of the gaps in current risk assessments and methods of public health authorities. …

Semi-Robotic Knee Arthroscopy System With Braking Mechanism, Thai Hua

Honors Undergraduate Theses

To alleviate the poor ergonomics which surgeons suffer during knee arthroscopy, a semi-robotic device with braking mechanism is created for intraoperative assistance. A slitted ball joint assembly is developed to transmit the clamping force to the arthroscope inside. Ball deformation and stress at various angles to the vertical and clamping forces is recorded through Abaqus Finite Element Analysis (FEA). Contact forces between the scope and inner surfaces of the ball is also computed in FEA at different clamping forces. The von Mises stress occurring in the ball joint is under the yield stress limit for polyethylene, and there is noticeable …

The Effects Of Virtual Reality-Based Mindfulness Meditation On Cognition, Rafael Leite

Honors Undergraduate Theses

Due to relatively recent strides made in the field of virtual reality, the technology's potential use in a clinical setting has been the focus of a growing body of research. Multiple studies focus on benefits of its combination with meditation interventions; however, few explore its impact following a short-term period of utilizing both. This investigation aims to explore that gap in the literature by determining whether an improvement on mindfulness and working memory test scores would be seen following a single session of virtual reality meditation. That was done by randomly assigning participants to one of two conditions. One group …

Characteristics Of Anxiety In Autistic Adults, Melissa Lewis

Honors Undergraduate Theses

Modern Autism Spectrum Disorder (ASD) research has shifted in focus from explaining a debilitating childhood illness to helping individuals of all ages, cultures, and intelligence navigate their social problems. Understanding of the adult perspective has also grown massively since the autism diagnosis changed in the Diagnostic Statistical Manual, Fifth Edition (DSM-5) in 2013 and has brought into question how the neurodevelopmental disorder affects the individual. Anxiety symptoms in ASD, like the existence of camouflaging, have proven unique only to ASD, and recent findings suggests that the cause of anxiety in autistic individuals may be due to fundamental differences in communication …

Possible Relationship Between Omega-3 Fatty Acid Supplementation And Recovery From Resistance Training, Saagar R. Patel

Honors Undergraduate Theses

The purpose of this thesis is to investigate the relationship between Omega-3 Fatty Acid supplementation and recovery from resistance training. Omega-3 Fatty Acids are a type of polyunsaturated fatty acid that is commonly found in marine sources. Omega-3 Fatty Acids are widely known for offering cardiovascular health benefits and for their anti-inflammatory properties, but their role in resistance training recovery is a relatively novel area of research. This review was conducted by qualitatively analyzing a collection of studies that have been published on the relationship between Omega-3 Fatty Acid supplementation and recovery from resistance training in either resistance-trained or untrained …

The Encapsulation Of Enzymes In Multiphase Complex Coacervates, Akash R. Rajaram

Honors Undergraduate Theses

Polyelectrolyte complex coacervates (PECCs) result from liquid-liquid phase separation (LLPS) in solutions containing oppositely charged polymers ¹. Multiphase polyelectrolyte complex coacervates (MPECCs) result from the combination of multiple, specific PECCs ². The encapsulation of proteins in PECCs can serve as promising vehicles for the effective delivery of protein-based therapeutics, which are notoriously difficult to deliver. The encapsulation of model proteins, such as Bovine Serum Albumin (BSA) ³ or Human Hemoglobin (Hb) ⁴ have illustrated the protein-encapsulating capabilities of these PECC systems. The encapsulation of proteins in MPECCs is a topic that has yet to be explored; however, it …

Provider Perceptions On The Usage Of Psychedelic-Assisted Therapy To Influence Behavior Change In Individuals With Substance Use Disorders, Leia T. Rausch

Honors Undergraduate Theses

Recent research studies and clinical trials have suggested that psychedelic therapy with psychological support can offer beneficial and synergistic effects in reducing or eliminating substance use disorder (SUD) patterns and symptoms. However, very little is known about SUD healthcare providers' perceptions of the usage of psychedelic-assisted therapy in SUD treatment. The present study assesses biomedical SUD healthcare providers' perceptions and concerns to better understand potential barriers to the effective implementation of psychedelic-based therapies and formulate further recommendations for research efforts surrounding them. This study collected data through a short survey and qualitative semi-structured interviews from nine participants involved in SUD …

The Role Of Mental Health Evaluations In The Prevention And Intervention Of School Shootings, Livine Saint-Louis

Honors Undergraduate Theses

In 2022, there were forty-two mass school shootings, a record that surpassed the previous years. As of April 2023, there have already been fourteen school shootings that have resulted in injury or death. Each year, the frequency of mass school shootings and the number of victims continue to rise. Regarding the shooters' characteristics, some have reported a history of mental illness, instability within the home, poor academic performance, and more. In the United States (U.S.), one out of five children and adolescents are diagnosed with mental health disorders (Brookman, 2017). This study will examine four significant perpetrators that committed mass …

Effect Of Molecular Crowders On The Activation Of Cholera Toxin By Protein Disulfide Isomerase, Niral Shah

Honors Undergraduate Theses

Cholera toxin (CT) is a classic A-B type protein toxin that has an A subunit (A1 + A2) and a pentameric B subunit. The catalytic A1 domain is linked to the A2 domain via a disulfide linkage. CTA1 must be dissociated from the rest of the toxin to cause a cytopathic effect. Protein disulfide isomerase (PDI) can reduce the CTA1/CTA2 disulfide bond, but disassembly of the reduced toxin requires the partial unfolding of PDI that occurs when it binds to CTA1. This unfolding event allows PDI to push CTA1 away from the rest of the toxin.

My research question is …

Investigating The Effects Of Paraquat On Kidney Disease Biomarkers In Hek293 Cells, Zounaira Shahzad

Honors Undergraduate Theses

Farmworkers in Apopka, FL, have been subjected to overhead pesticide exposure since the 1940s. Pesticides including Paraquat (PQ), Metribuzin and Aldicarb were sprayed onto the field while farmworkers worked. In "Fed Up: The High Cost of Cheap Food," farmworkers recalled the physical toll these conditions took on their bodies, blaming pesticides for their diseases, such as chronic kidney disease (CKD). While established that pesticides, specifically PQ, may be involved in some forms of Parkinson's disease, no explicit connection has been identified for SLE, CKD, and other diseases experienced by farm workers. This study evaluated whether pesticides could contribute to kidney …

Soft Skills In Stem, Mariana Sorroza Aguilar

Honors Undergraduate Theses

Those working in science, technology, engineering, and math (STEM) fields are delivering world-changing solutions to the problems we face and are saving lives every day. Some of them do surgeries, some design airplanes and cars, others study the wildlife around us, and others create processes to facilitate the manufacturing of devices we use often. In order to do this, the engineers, scientists, doctors, and other professionals in STEM disciplines need to possess hard skills. Hard skills are often called technical skills and are measurable abilities and skills that are needed to perform tasks effectively. The tasks done share something in …

The Efficacy Of Treatment Of Symptoms Of Polycystic Ovarian Syndrome And Associated Health Risks Using Insulin Sensitizers: A Meta-Analysis, Isabella J. Wong

Honors Undergraduate Theses

Polycystic Ovarian Syndrome (PCOS) is common among women of reproductive age (ages 15-49), and it can put patients at higher risk for diseases such as type II diabetes or coronary heart disease. While the mechanisms behind PCOS are poorly understood, it is diagnosed using two characteristics: hyperandrogenism and anovulation. Once diagnosed, many patients are also tested for insulin resistance (IR). While IR is thought of as a symptom of PCOS, this study will examine the effects of treatment of IR to manage symptoms of PCOS rather than treatment of hyperandrogenism. This meta-analysis used data from studies previously published by searching …

The Effects Of Psychiatric And Physical Cannabis Use Motivational Categories On The Development Of Cannabis Use Disorder, Kassidy B. Jacques

Honors Undergraduate Theses

The legalization of cannabis is increasing across the United States, for both recreational and medical use. This has resulted in a change in public opinion regarding the risks of cannabis use. This is particularly true for the current generation of older adults, which experiences a greater prevalence of cannabis use than previous members of this cohort. Due to decreased perception of risk and medical or emotional issues associated with old age, older adults increasingly use cannabis to cope with their psychiatric and medical symptoms. Current studies provide evidence of an association between using cannabis for medical symptoms and the development …

Associations Between Perfectionism, Self-Discrepancy, And Loss Of Control Eating, Dalaia Hernandez

Honors Undergraduate Theses

OBJECTIVE: Research has shown a clear relationship between perfectionism and other pathology including eating disorders, typically restrictive and purging disorders such as Anorexia Nervosa and Bulimia Nervosa. However, the relationship between perfectionism and loss of control eating disorder had not been explored. Similarly, we suspect there to be a relationship between perfectionism and self-discrepancy, and that shame might be a mediating variable in the relationship between these constructs and loss of control eating. This study investigated the relationship between these three variables to better understand how shame mediates or moderates the relationship between perfectionism, self-discrepancy, and loss of control eating. …

Prevention Of Perineal Tearing During Childbirth: A Literature Review, Victoria Manzo

Honors Undergraduate Theses

Perineal lacerations can be caused by a variety of risk factors such as a large fetal head circumference, birthing positions that place strain on the sacrum, and first-time births. Preventing perineal tears can be challenging for laboring women. Exploring the possible prevention methods to decrease the severity of perineal tearing or preventing it altogether can be beneficial for laboring women's physical and mental health. The primary purpose of this literature review was to examine which interventions are most likely to prevent perineal tearing during childbirth. The secondary purpose was to evaluate natural perineal tears in comparison to surgical incision, or …

Diet Change Over Time In The Ais Community Of Cape Canaveral, Florida, Allyson Shenkman

Honors Undergraduate Theses

Diet change over time is assessed for a Malabar II period (900 C.E. to 1565 C.E.) Ais indigenous community in Cape Canaveral, Florida, at the Penny Plot site (8BR158). To this end, 7,760 faunal fragments were examined, with 1,876 identified at the species, genus, or family level. Through identification and analysis of faunal remains, it can be concluded that, while the amounts of overall remains left behind as a whole increased, there were no significant changes in the types of fauna utilized or patterns of consumption. This suggests that the indigenous people who occupied this site managed their resources very …

Investigating Mobility Across The Life Course Through Stable Isotope Analysis At The Early Medieval Site Of Berettyóújfalu Somata, Hungary, Brianna Jayne Muir

Electronic Theses and Dissertations, 2020-2023

The Migration Period (375 to 568 CE) of Central and Eastern Europe was a tumultuous time politically, culturally, and socially. Historical and archaeological evidence provide support for the large-scale movement of multiple tribes and groups, including the Gepids and Avars, although biogeochemical evidence for mobility is currently limited for these populations. Mobility can impact individual and group health and identity, and has socio-political implications for broader regions involved. As such, identifying the extent and scale of mobility within a given population can provide nuanced insights into multiple aspects of life and society in the past. To investigate mobility in a …

Exploring Population Structure And Diversity Across Time In Population Of American Flamingos (Phoenicopterus Ruber), Jessica Folsom

Electronic Theses and Dissertations, 2020-2023

Dispersal and connectivity within a population often promotes overall diversity and adaptive potential, therefore a disruption of existing patterns of connectivity by local extinction can have significant consequences for the affected species. However, the extent of these impacts on recovery is not always known. American flamingos (Phoenicopterus ruber) present an ideal opportunity to investigate how changes in gene flow influence within population diversity and genetic structure over the span of a century for a recovering population. Flamingos were highly sought-after by hunters for their meat and feathers, and as a result, the Florida population was extirpated by the beginning of …

Following Faculty Engaging In Collaborative Action Research To Approach Curricular Change In Undergraduate Biochemistry, Christopher Nix

Electronic Theses and Dissertations, 2020-2023

This study engaged in a curricular redesign of an undergraduate biochemistry course undertaken by a collaborative action research group. The initial portion of this study investigated student conceptual understanding of foundational concepts via a rigorously tested concept inventory. the impact of the redesign on the student foundational conceptual understanding was determined by comparison with a baseline data set. Findings suggest that students enter and exit the biochemistry course with little understanding of key foundational concepts. Examination of student performance after the incorporation of creative exercises showed a significant impact of the curricular changes on two of the concepts of interest. …

Responses Of A Pine Flatwoods Specialist Treefrog To Prescribed Fire, Ian Biazzo

Electronic Theses and Dissertations, 2020-2023

Coarse outcomes of prescribed fires are well-understood, but fine scale impacts on many assemblages are still unknown. When fire approaches, animals escape to unburned areas, hide in place, or are killed by fire. Treefrogs are unique in their use of trees for most of their adult nonbreeding activities. This reliance on uplands and three-dimensional landscape composition makes them a great model to study prescribed fire impacts. We focused analyses on an upland flatwoods specialist comprising 99% of our captures, the pinewoods treefrog Dryophytes femoralis. We assessed this species' responses to prescribed fire using two separate before-after-control-impact replicated field experiments in …

Refining The Use Of Stable Isotope Analysis In Detecting Wildlife Laundering, Kevin Guilfoyle

Electronic Theses and Dissertations, 2020-2023

The international wildlife trade has caused significant declines in wild populations. Captive breeding can reduce the pressure on wild populations caused by overcollection, but if not properly monitored, wildlife laundering can lead to further population declines. Improving the forensic ability to detect wildlife laundering will assist in monitoring the wildlife trade and enforcing regulations, thereby aiding recovery of wild populations. Stable isotope analysis has grown in importance as a forensic tool, but improvements are needed. Here, stable isotope analysis (δ13C) on eggshells of captive bred and wild sourced island apple snails (Pomacea maculata) distinguished between the two; eggshells of captive …

Variation In Genetic Structure And Dispersal Of Juvenile Green Turtles, Gustavo Stahelin

Electronic Theses and Dissertations, 2020-2023

Sea turtles are long-lived, globally distributed animals with a complex life-history. Individuals from different populations often share the same foraging areas (mixed stock aggregations). Understanding patterns of dispersal and connectivity between reproductive populations and mixed stock aggregations is fundamental for the development of effective conservation plans. Recently, green sea turtle (Chelonia mydas) populations in several reproductive areas have increased, providing an opportunity to evaluate how demographic changes in reproductive areas impact dispersal to, and the composition of, mixed stock aggregations. In this dissertation, I evaluated how dispersal from reproductive populations in the Greater Caribbean to mixed stock aggregations may have …

Comparing Hydrogen Peroxide And Sodium Perborate Ultraviolet Advanced Oxidation Processes For 1,4-Dioxane Removal From Wastewater Effluent, Tulsi Shukla

Electronic Theses and Dissertations, 2020-2023

Ultraviolet advanced oxidation processes were compared using sodium perborate (UV/NaBO3 AOP) or hydrogen peroxide (UV/H2O2 AOP) for 1,4-dioxane removal from tertiary wastewater effluent. Both UV/H2O2 and UV/NaBO3 AOPs were also tested with the addition of acetic acid. Results revealed that sodium perborate performed similarly to hydrogen peroxide – the UV/NaBO3 AOP with 6 milligrams per liter (mg/L) as H2O2 resulted in 43.9 percent 1,4-dioxane removal, while an equivalent UV/H2O2 AOP showed 42.8 percent removal. Although the oxidants performed similarly, NaBO3 is an average of 3.3 times more expensive than H2O2. However, the solid form of NaBO3 can provide a major …

Preservice Teacher Intersectional Awareness: A Qualitative Inquiry, Lindsey Pike

Electronic Theses and Dissertations, 2020-2023

The purpose of this dissertation was to investigate the intersectional awareness of preservice general education teachers as experienced through an internship in an urban, Title 1 funded school. Intersectionality Theory (Boveda, 2016; Crenshaw, 1990; Dill & Zambrana, 2009; Jones & Wijeyesinghe, 2011) was used as a theoretical framework to inform this study. A descriptive phenomenological design (Creswell, 2013; Moustakas, 1994) was used to examine preservice teachers' (PSTs)lived experiences within their teacher preparation program courses and internship. Data were collected through individual semi-structured interviews with preservice general education teachers. Data analysis was completed using Colaizzi's (1978) seven-step process as outlined by …

Probing Endothelial Cell Mechanics Under Disturbed Fluid Flow, Jingwen Wu

Electronic Theses and Dissertations, 2020-2023

Endothelial cells, which form the inner layer of the vasculature, interact with the extracellular matrix (ECM) by exerting mechanical contractile cell-substrate stress called tractions and cell-cell stresses called intercellular stresses. This cellular mechanical behavior involves many fundamental biological processes, including cell migration, differentiation, angiogenesis, and wound healing. Also, the inner surface of the vasculature, where endothelial cells reside, is constantly exposed to various fluid flows. The most variable fluid flow regimes occur primarily within branching regions of the vasculature. Endothelial cells residing within these regions experience disturbed flow, which consists of irregular flow patterns and extreme wall shear stress gradients. …

Lived Experience At Plinkaigalis, Lithuania: An Integrated Approach Using Stable Isotope, Spatial, And Statistical Analyses, Alexandria Orozco

Electronic Theses and Dissertations, 2020-2023

The Migration period (4th-7th century AD) represents a time of major sociopolitical change, but relatively little is known about this time in Lithuania's history (Bliujien?, 2013; Jankauskas & Kozlovskaya, 1999). The focus of this dissertation is to understand the lived experiences of individuals interred in the Migration Period cemetery at Plinkaigalis, Lithuania, through integrated analyses of stable isotope, statistical and spatial methods to assess 253 human bone/tooth samples. Isotopic analysis included assessments of stable carbon, nitrogen, and oxygen stable isotope values. Statistical analysis included a MANOVA (Multivariate Analysis of Variance) test. Spatial methods included buffers, kernel density, spatial statistics (Moran's …

Low Energy Photon Detection, Tianyi Guo

Graduate Thesis and Dissertation 2023-2024

Detecting long wave infrared (LWIR) light at room temperature has posed a persistent challenge due to the low energy of photons. The pursuit of an affordable, high-performance LWIR camera capable of room temperature detection has spanned several decades. In the realm of contemporary LWIR detectors, they can be broadly classified into two categories: cooled and uncooled detectors. Cooled detectors, such as MCT detectors, excel in terms of high detectivity and fast response times. However, their reliance on cryogenic cooling significantly escalates their cost and restricts their practical applications. In contrast, uncooled detectors, exemplified by microbolometers, are capable of functioning at …

Optimizing Deep Neural Networks Performance: Efficient Techniques For Training And Inference, Ankit Sharma

Graduate Thesis and Dissertation 2023-2024

Recent advances in computer vision tasks are mainly due to the success of large deep neural networks. The current state-of-the-art models have high computational costs during inference and suffer from a high memory footprint. Therefore, deploying these large networks on edge devices remains a serious concern. Furthermore, training these over-parameterized networks is computationally expensive and requires a longer training time. Thus, there is a demand to develop techniques that can efficiently reduce training costs and also be able to deploy neural networks on mobile and embedded devices. This dissertation presents practices like designing a lightweight network architecture and increasing network …

Dna Capture And Translocation Through Nanopore, Swarnadeep Seth

Graduate Thesis and Dissertation 2023-2024

This thesis investigates DNA dynamics and translocation through nanopores using Brownian dynamics (BD) simulations, offering insights into sequencing technologies, DNA marker detection, and accurate barcoding utilizing solid-state nanopore platforms. First, we in silico study the intricate process of capture and translocation in a single nanopore. Our simulation reveals a high probability of hairpin loop formation during the capture process. However, attaching a charged tag to one end of DNA improves multi-scan rates and enhances unidirectional translocations. We use modulating voltage biases to multi-scan a lambda-phage dsDNA with oligonucleotide flap markers (tags) through a single and double nanopore system. Our study …

Painting And Fear: The Creation Of Death's Visage, Mark A. Felbinger

Graduate Thesis and Dissertation 2023-2024

Death's Visage is a feature film that was created from an idea developed due to a personal relationship with an artist, who was a professional illustrator and painter. The film follows a young woman who becomes entrapped in a demonic sphere and time zone where her fear is the demon's gratification. She questions the events that are unfolding, which creates herpsychological turmoil, while taking place in the family home that is in an older established middle-class neighborhood.

Death's Visage was a micro-budgeted film produced for $20,778. The capital needed for this film meets the University of Central Florida Feature Film …