Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Central Florida

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 2941 - 2970 of 7872

Full-Text Articles in Entire DC Network

Physiological Constraints On Warm-Water Habitat Site Selection And Utilization By The Florida Manatee (Trichechus Manatus Latirostris) In East Central Florida, Ann Spellman Jan 2014

Physiological Constraints On Warm-Water Habitat Site Selection And Utilization By The Florida Manatee (Trichechus Manatus Latirostris) In East Central Florida, Ann Spellman

Electronic Theses and Dissertations

Living at the northern limits of its geographic range, the Florida manatee is particularly susceptible to cold stress-related mortality during the winter months, with most deaths occurring in the lower two-thirds of the state. Contributing to this cold stress susceptibility is the manatee's limited physiological and behavioral responses available when thermally stressed. While capable of migrating south in response to falling water temperatures, manatees must still find warm water when ambient river temperature drops below 20°C for more than a few days. This is in part due to the species low metabolic rate, limited capacity for thermogenesis, and limited ability …

Go to article

Role Of Cardiac Catecholamines In Embryos And Adults Under Stress, Candice Baker Jan 2014

Role Of Cardiac Catecholamines In Embryos And Adults Under Stress, Candice Baker

Electronic Theses and Dissertations

Cardiovascular disease is responsible for the loss of one life every 38 seconds and accounts for 26.6 percent of all infants that die of congenital birth defects. Adrenergic hormones are critically important regulators of cardiovascular physiology in embryos and adults. They are key mediators of stress responses and have profound stimulatory effects on cardiovascular function, and dysregulation of adrenergic function has been associated with many adverse cardiac conditions, including congenital malformations, arrhythmias, ischemic heart disease, heart failure, and sudden cardiac death. Despite intensive study, the specific roles these hormones play in the developing heart is not well-understood. Further, there is …

Go to article

Structural And Functional Studies Of Glycine Riboswitches And Development Of Fab Chaperone Assisted Rna Crystallography, Eileen Sherman Jan 2014

Structural And Functional Studies Of Glycine Riboswitches And Development Of Fab Chaperone Assisted Rna Crystallography, Eileen Sherman

Electronic Theses and Dissertations

The glycine riboswitch is a structured RNA found upstream of genes in mRNA transcripts in many bacteria, functioning as a biofeedback gene regulator. Upon binding glycine, a complete RNA transcript including gene sequences is transcribed, effectively turning on gene expression. In an effort to understand the intricacies of its functioning, many mutants of the riboswitch were made and characterized during Ph. D. work, resulting in discovery of a P0 duplex/kink-turn motif involving a few nucleotides upstream of the established glycine riboswitch sequence which changed its ligand binding characteristics (Chapter 1). Previously, the two aptamers of the riboswitch were thought to …

Go to article

Catholic Healing Masses: Intersections Of Health And Healing In Yucatan, Suzanne Draper Jan 2014

Catholic Healing Masses: Intersections Of Health And Healing In Yucatan, Suzanne Draper

Electronic Theses and Dissertations

The conception of illness and healing in contemporary Mexican Catholic discourse highlights both particular and ubiquitous instances of a health experience perceived locally and widespread. Catholic healing masses are utilized as supplemental methods of individual health restoration coupled with Western medicinal techniques in Catholic dramas. Aside from the spiritual and religious significance of this practice, the use of healing masses as an additional means to achieving an optimal health status implies that something is lacking in current biomedical models. The purpose of my research is to explore the humanistic terms under which healing masses operate and translate these terms into …

Go to article

Ar Physics: Transforming Physics Diagrammatic Representations On Paper Into Interactive Simulations., Yao Zhou Jan 2014

Ar Physics: Transforming Physics Diagrammatic Representations On Paper Into Interactive Simulations., Yao Zhou

Electronic Theses and Dissertations

A problem representation is a cognitive structure created by the solver in correspondence to the problem. Sketching representative diagrams in the domain of physics encourages a problem solving strategy that starts from 'envisionment' by which one internally simulates the physical events and predicts outcomes. Research studies also show that sketching representative diagrams improves learner's performance in solving physics problems. The pedagogic benefits of sketching representations on paper make this traditional learning strategy remain pivotal and worthwhile to be preserved and integrated into the current digital learning landscape. In this paper, I describe AR Physics, an Augmented Reality based application that …

Go to article

A Thomistic Critique Of The Ethics Of Alasdair Macintyre, Marcus Otte Jan 2014

A Thomistic Critique Of The Ethics Of Alasdair Macintyre, Marcus Otte

Electronic Theses and Dissertations

Alasdair MacIntyre argues in favor of a historicist Thomism in ethics and political philosophy. In his theory, sociological categories take up much of the space traditionally occupied by metaphysics. This peculiar feature of MacIntyre's Thomism, and its merits and demerits, is already a subject that has been taken up by many critics. In this thesis, these criticisms are supplemented and unified by identifying what is perhaps the most fundamental difficulty with MacIntyre's ethics: his version of Thomism is problematic because it treats epistemology as first philosophy. This misstep compromises MacIntyre's ability to provide a defense of moral objectivity, while also …

Go to article

Evaluation Of A Digitally-Automated Alcohol Curriculum Designed To Alter Expectancies And Alcohol Use In First Year College Students, Amy Schreiner Jan 2014

Evaluation Of A Digitally-Automated Alcohol Curriculum Designed To Alter Expectancies And Alcohol Use In First Year College Students, Amy Schreiner

Electronic Theses and Dissertations

High-risk alcohol consumption remains a primary public health concern for students on college campuses. In response to this concern the National Advisory Council of the National Institute on Alcohol Abuse and Alcoholism created a task force to identify and recommend strategies to aid college administrators in implementing effective alcohol programming at their institutions. While most administrators report being aware of these recommendations, many have not successfully implemented empirically supported interventions on their campuses. One significant barrier is the cost and difficulty of training and hiring skilled staff to implement these interventions. Of the strategies identified as effective, challenging alcohol expectancies …

Go to article

How Many Are Out There? A Novel Approach For Open And Closed Systems, Zia Rehman Jan 2014

How Many Are Out There? A Novel Approach For Open And Closed Systems, Zia Rehman

Electronic Theses and Dissertations

We propose a ratio estimator to determine population estimates using capture-recapture sampling. It's different than traditional approaches in the following ways: (1) Ordering of recaptures: Currently data sets do not take into account the "ordering" of the recaptures, although this crucial information is available to them at no cost. (2) Dependence of trials and cluster sampling: Our model explicitly considers trials to be dependent and improves existing literature which assumes independence. (3) Rate of convergence: The percentage sampled has an inverse relationship with population size, for a chosen degree of accuracy. (4) Asymptotic Attainment of Minimum Variance (Open Systems: (=population …

Go to article

Integral Projection Models Reveal Interactive Effects Of Biotic Factors And Disturbance On Plant Demography, Matthew Tye Jan 2014

Integral Projection Models Reveal Interactive Effects Of Biotic Factors And Disturbance On Plant Demography, Matthew Tye

Electronic Theses and Dissertations

Understanding factors limiting population growth is crucial to evaluating species persistence in changing environments. I used Integral Projection Models (IPMs) to elucidate the role of biotic interactions and disturbance on population growth rate in two plants: Helianthemum squamatum, a perennial endemic to gypsum habitats in central Spain, and Liatris ohlingerae, a long-lived perennial endemic to the Lake Wales Ridge of central Florida. In H. squamatum, there was a strong positive effect of trampling in the site with the highest plant density and moderate positive effects of seed addition in the site with the lowest plant density. Differences in treatment effectiveness …

Go to article

A Comparative Study Of The Effect Of Block Scheduling And Traditional Scheduling On Student Achievement For The Florida Algebra 1 End-Of-Course Examination, Arthur Underwood Jan 2014

A Comparative Study Of The Effect Of Block Scheduling And Traditional Scheduling On Student Achievement For The Florida Algebra 1 End-Of-Course Examination, Arthur Underwood

Electronic Theses and Dissertations

The focus of this research was on the effect of school schedules on student achievement for ninth-grade students in a Florida school district. Data were collected from two central Florida high schools from the 2011-2012 and 2012-2013 school years. Five one-way analyses of covariance (ANCOVA) were performed to ascertain if there was any interaction between school schedules and student achievement. Examined were the interactions (a) between schedule and schools, (b) schedule and male students, (c) schedule and female students, (d) schedule and Black students, and (e) schedule and Hispanic students. The independent variable, school schedule, consisted of two levels: traditional …

Go to article

A Professional Learning Community Design: Using Close Reading Techniques To Improve The U.S. History Comprehension, Maureen Tinsley Jan 2014

A Professional Learning Community Design: Using Close Reading Techniques To Improve The U.S. History Comprehension, Maureen Tinsley

Electronic Theses and Dissertations

This dissertation in practice presents a research-based model for staff development utilizing the elements of a professional learning community. The focus of this problem of practice was determined through an analysis of one high school's reading data indicating that 36% of the student body was reading below grade level according to the state assessment test for reading. Researchers have noted that reading demands for college and careers have increased (Alliance for Excellent Education, 2011; Barton, 2000; Common Core State Standards, 2014). If students do not develop reading proficiency to graduate with a high school diploma, they are at risk of …

Go to article

In Vitro Characterization Of Unmodified And Pyroglutamylated Alzheimer's Amyloid Beta Peptide, Jason Matos Jan 2014

In Vitro Characterization Of Unmodified And Pyroglutamylated Alzheimer's Amyloid Beta Peptide, Jason Matos

Electronic Theses and Dissertations

Plaques of amyloid β peptide (Aβ) are a hallmark trait of Alzheimer’s disease (AD). However, the precise role of Aβ aggregates is not well understood. Recent studies have identified that naturally occurring N-terminal truncation and pyroglutamylation of Aβ significantly increases its neurotoxicity by an unknown mechanism. Content of pyroglutamylated Aβ (pE-Aβ) in AD brains has been shown to reach up to 50% of total Aβ. Modified pE-Aβ co-aggregates with Aβ by a seeding mechanism and forms structurally distinct and highly toxic oligomers. We studied structural transitions of the full-length Aβ1-42, its pyroglutamylated form AβpE3-42, their 9:1 (Aβ1-42/AβpE3-42) and 1:1 molar …

Go to article

Effects Of Mechanical Habitat Disturbance On The Diversity And Network Structure Of Plant-Bee Interaction Networks In Central Florida, Karlie Carman Jan 2014

Effects Of Mechanical Habitat Disturbance On The Diversity And Network Structure Of Plant-Bee Interaction Networks In Central Florida, Karlie Carman

Electronic Theses and Dissertations

Ecological interactions within a community shape the structure of ecosystems and influence ecosystem function. Plant-pollinator interactions exist as mutualistic exchange networks that may collapse as habitat loss occurs, thereby threatening the overall health of an ecosystem. Understanding the impacts of human-mediated habitat disturbance on ecological interactions is therefore crucial for conservation efforts. Archbold Biological Station (ABS) in Venus, Florida contains over 2000 hectares of protected Florida scrub habitat nested within a human-dominated environment that is threatened by anthropogenic habitat disturbance. In past studies, over 113 bee species and 157 associated host plants, many endemic to the Lake Wales Ridge, have …

Go to article

Effects Of Biotic Interactions On Coastal Wetland Communities With Applications For Restoration, Melinda Donnelly Jan 2014

Effects Of Biotic Interactions On Coastal Wetland Communities With Applications For Restoration, Melinda Donnelly

Electronic Theses and Dissertations

Coastal wetland plants serve as ecological engineers in a physiologically stressful environment and the loss of coastal wetlands can cause negative effects throughout the estuarine system. Due to increased degradation of coastal habitats worldwide, interest in restoration has increased around the world. An understanding of the biotic processes affecting species distribution and diversity is critical for future conservation, management, and restoration of coastal wetlands. The purpose of my study was to test the effects of biotic interactions on native coastal wetland plants and determine how these interactions may be incorporated into current and future restoration projects. I had three primary …

Go to article

Admission Criteria For Schools Of Business: Common Prerequisites And Academic Performance In Upper-Level Business Coursework, Helen Becker Jan 2014

Admission Criteria For Schools Of Business: Common Prerequisites And Academic Performance In Upper-Level Business Coursework, Helen Becker

Electronic Theses and Dissertations

Schools of business within the Florida State University system have state-mandated common prerequisites that students are required to complete prior to formal admission into baccalaureate business programs. As such, the common prerequisites serve as minimum admission requirements for schools of business in the state of Florida. This study sought to determine the ability of these discipline specific admission criteria to predict academic performance in upper-level business coursework. This study looked at existing data for 860 students in the College of Business Administration at the University of Central Florida. Findings of the study demonstrate that there is a positive and moderate …

Go to article

Application Of Two-Photon Absorbing Fluorene-Containing Compounds In Bioimaging And Photodyanimc Therapy, Xiling Yue Jan 2014

Application Of Two-Photon Absorbing Fluorene-Containing Compounds In Bioimaging And Photodyanimc Therapy, Xiling Yue

Electronic Theses and Dissertations

Two-photon absorbing (2PA) materials has been widely studied for their highly localized excitation and nonlinear excitation efficiency. Application of 2PA materials includes fluorescence imaging, microfabrication, 3D data storage, photodynamic therapy, etc. Many materials have good 2PA photophysical properties, among which, the fluorenyl structure and its derivatives have attracted attention with their high 2PA cross-section and high fluorescence quantum yield. Herein, several compounds with 2PA properties are discussed. All of these compounds contain one or two fluorenyl core units as part of the conjugated system. The aim of this dissertation is to discuss the application of these compounds according to their …

Go to article

Establishment Of Methods For Isolation Of Pnmt+ Cardiac Progenitor Cells, Namita Varudkar Jan 2014

Establishment Of Methods For Isolation Of Pnmt+ Cardiac Progenitor Cells, Namita Varudkar

Electronic Theses and Dissertations

Cardiovascular disease is the leading cause of death in the United States. Millions of patients suffer each year from endothelial dysfunction and/or debilitating myocardial damage resulting in decreased quality of life and increased risk of death or disablement. Current pharmacological approaches are only partly effective at treating cardiovascular disease, and hence, better strategies are needed to provide significant improvements in treatment options. Cardiac stem/progenitor cells have the potential to regenerate myocardial tissue and repair damaged heart muscle. There are many different types of cardiac progenitor cells, and each may have certain unique properties and characteristics that would likely be useful …

Go to article

Genetic And Biochemical Characterization Of The Roles Of Two Putative Purine Transporters In The Infectious Cycle Of Borrelia Burgdorferi, Sunny Jain Jan 2014

Genetic And Biochemical Characterization Of The Roles Of Two Putative Purine Transporters In The Infectious Cycle Of Borrelia Burgdorferi, Sunny Jain

Electronic Theses and Dissertations

Lyme disease, the most common tick borne disease in United States, is caused by the bacterial pathogen Borrelia burgdorferi. In nature, B. burgdorferi exists in an enzootic infectious cycle between an arthropod vector and mammalian hosts. Identification and characterization of the genes essential for B. burgdorferi survival throughout its infectious cycle is an important step toward understanding the molecular mechanisms involved in B. burgdorferi pathogenesis. B. burgdorferi contains a small genome, which lacks the genes encoding for the enzymes required for de novo synthesis of amino acids, fatty acids and nucleic acid precursors. Therefore, the spirochete is dependent upon the …

Go to article

Novice Science Teachers' Thinking About The Purpose Of Teachers' Questions, Gwyndolyn Crittenden Jan 2014

Novice Science Teachers' Thinking About The Purpose Of Teachers' Questions, Gwyndolyn Crittenden

Electronic Theses and Dissertations

Effective teacher questioning during whole group instruction remains an important pedagogy in science education, especially the importance of helping novice teachers to guide student thinking using effective questions. This study examined how novice secondary science teachers’ understand the relationship between student thinking and teacher questioning. The sample was seven novice secondary science teachers’ enrolled in the University of Central Florida’s job embedded Resident Teacher Professional Preparation Program (RTP3 ). All participants received instruction and guided practice with the use of questions to elicit, probe, and challenge student ideas in the secondary science pedagogy class. Participants completed a questionnaire describing their …

Go to article

The Influence Of A Career Planning Stem Explorations Course On Vocational Maturity, Career Decidedness And Career Thoughts For Undergraduate Students, Diandra Prescod Jan 2014

The Influence Of A Career Planning Stem Explorations Course On Vocational Maturity, Career Decidedness And Career Thoughts For Undergraduate Students, Diandra Prescod

Electronic Theses and Dissertations

According to the National Academy of Sciences (NAS), innovation that accompanies careers in science, technology engineering, and math (STEM) create a driving force in the economy and the creation of jobs, yet many positions remain open due to the lack of qualified individuals to fill them (NAS, 2011). Continuing research and innovation proves to be important, yet not enough students graduate with STEM degrees and enter into STEM careers. Career planning courses for undergraduate students increase student confidence about their abilities to make career decisions (Grier-Reed & Skaar, 2010: Scott & Ciani 2008). Vocational maturity and career decision making skills …

Go to article

Validation Of A Novel Hypothesis Of Generating Foam Cells By Its Use To Study Reverse Cholesterol Transport, Bhaswati Sengupta Jan 2014

Validation Of A Novel Hypothesis Of Generating Foam Cells By Its Use To Study Reverse Cholesterol Transport, Bhaswati Sengupta

Electronic Theses and Dissertations

Generation of foam cells, an essential step for reverse cholesterol transport (RCT) studies, uses the technique of receptor dependent macrophage loading with radiolabeled acetylated Low Density Lipoprotein (Ac-LDL). In this study, we used the ability of a biologically relevant detergent molecule, Lysophosphatidylcholine (Lyso PtdCho), to form mixed micelles with cholesterol or cholesteryl ester (CE) to generate macrophage foam cells. Fluorescent or radiolabelled cholesterol / Lyso PtdCho mixed micelles were prepared and incubated with RAW 264.7 or mouse peritoneal macrophages. Results showed that such micelles were quite stable at 4°C and retained the solubilized cholesterol during one month storage. Macrophages incubated …

Go to article

A Time-Course Analysis Of Behavioral Plasticity And Differential Gene Expression Patterns In Response To Density In Schistocerca Americana (Orthoptera: Acrididae), Steven Gotham Jan 2014

A Time-Course Analysis Of Behavioral Plasticity And Differential Gene Expression Patterns In Response To Density In Schistocerca Americana (Orthoptera: Acrididae), Steven Gotham

Electronic Theses and Dissertations

Phenotypic plasticity is the ability of the genotype to express alternative phenotypes in response to different environmental conditions and this is considered to be an adaptation in which a species can survive and persist in a rapidly changing environment. Some grasshoppers and locusts are capable of expressing an extreme form of density-dependent phenotypic plasticity, known as locust phase polyphenism. At low population density, the individuals typically have a cryptic coloration as nymphs, are less active, and only seek out conspecifics for reproductive purposes. At high density, however, they develop a drastically different phenotype in which they have a conspicuous coloration, …

Go to article

Action Potentials As Indicators Of Metabolic Perturbations For Temporal Proteomic Analysis, Aditya Reddy Kolli Jan 2014

Action Potentials As Indicators Of Metabolic Perturbations For Temporal Proteomic Analysis, Aditya Reddy Kolli

Electronic Theses and Dissertations

The single largest cause of compound attrition during drug development is due to inadequate tools capable of predicting and identifying protein interactions. Several tools have been developed to explore how a compound interferes with specific pathways. However, these tools lack the potential to chronically monitor the time dependent temporal changes in complex biochemical networks, thus limiting our ability to identify possible secondary signaling pathways that could lead to potential toxicity. To overcome this, we have developed an in silico neuronal-metabolic model by coupling the membrane electrical activity to intracellular biochemical pathways that would enable us to perform non-invasive temporal proteomics. …

Go to article

Multifunctional And Responsive Polyelectrolyte Nanostructures, Astha Malhotra Jan 2014

Multifunctional And Responsive Polyelectrolyte Nanostructures, Astha Malhotra

Electronic Theses and Dissertations

A polyelectrolyte complex is formed by mixing two oppositely charged polyelectrolytes in a solution. The electrostatic interactions between partially charged polymeric chains lead to the formation of a stable complex while avoiding the use of covalent cross linkers. Since complex formation can improve the stability of polyelectrolyte and metal ions in polyelectrolyte can provide various functionalities, PECs incorporated with metal ions are promising candidates for manufacturing stable and multifunctional structures. While the coordination of metal ions and polyelectrolytes has been extensively investigated in solutions and multilayer films, to our knowledge, no research has been performed to study the effect of …

Go to article

Chemical Differentiation Of Human Osseous, Non-Human Osseous, And Non-Osseous Materials Using Scanning Electron Microscopy - Energy Dispersive X-Ray Spectrometry (Sem/Edx) And Multivariate Statistical Analysis, Cayli Meizel-Lambert Jan 2014

Chemical Differentiation Of Human Osseous, Non-Human Osseous, And Non-Osseous Materials Using Scanning Electron Microscopy - Energy Dispersive X-Ray Spectrometry (Sem/Edx) And Multivariate Statistical Analysis, Cayli Meizel-Lambert

Electronic Theses and Dissertations

Identification of osseous materials is generally established on gross anatomical factors; however, highly fragmented or taphonomically altered materials are often problematic and alternative methods, such as biological, histological, or chemical analysis, must be utilized. Recently, chemical methods have been proposed to sort unknown materials according to their Ca/P ratios. Ubelaker and colleagues (2002) proposed using SEM/EDX to achieve this distinction and Christensen and colleagues (2012) have validated X-ray Fluorescence Spectrometry (XRF) for this application. An alternative method of analysis involves performing principal component analysis (PCA) on element spectra to classify unknown materials based on their trace element composition. Zimmerman (2013) …

Go to article

Diet At Medieval Alytus, Lithuania: Stable Carbon And Nitrogen Isotope Analysis Of Bone And Dentin Collagen, Katie Whitmore Jan 2014

Diet At Medieval Alytus, Lithuania: Stable Carbon And Nitrogen Isotope Analysis Of Bone And Dentin Collagen, Katie Whitmore

Electronic Theses and Dissertations

The Baltic region was a vibrant center of power and economic prosperity in medieval Europe; Lithuania in particular. Until now, little stable isotopic analysis has been utilized to assess diet in this region during this time period. The aim of this study was to undertake a preliminary assessment of the composition of diet at late medieval Alytus (late 14th to early 18th centuries) from bone (N=35) and dentin (N=38) collagen samples. The stable carbon isotopic data suggest a diet primarily comprised of C3 plants such as barley, rye, wheat, and flax, and animals consuming C3 plants. The stable nitrogen isotopic …

Go to article

Cerium Oxide Nanoparticles: Their Phosphatase Activity And Its Control, Atul Dhall Jan 2014

Cerium Oxide Nanoparticles: Their Phosphatase Activity And Its Control, Atul Dhall

Electronic Theses and Dissertations

Cerium oxide nanoparticles are established scavengers of reactive oxygen and nitrogen species. They have many potential biomedical applications that depend on their physicochemical properties and mode of preparation. Recent studies have found these nanoparticles possess phosphatase mimetic activity. Studying such catalytic activities will qualify their biomedical applications and render information on their bioavailability and potential toxicity. Two oxidation states of cerium exist in these nanoparticles (3+ or 4+). It is hypothesized that the oxidation state of cerium in the nanoparticles determines the amount of adsorbed water on the crystal lattices. This in turn governs their activity as phosphatases. Nanoparticles with …

Go to article

Understanding The Effect Of Formulaic Language On Esl Teachers' Perceptions Of Advanced L2 Writing: An Application Of Corpus-Identified Formulaic Language, Alison Youngblood Jan 2014

Understanding The Effect Of Formulaic Language On Esl Teachers' Perceptions Of Advanced L2 Writing: An Application Of Corpus-Identified Formulaic Language, Alison Youngblood

Electronic Theses and Dissertations

A quantitative study was conducted to determine if the amount of formulaic language influenced ESL teachers' perceptions (n=102) of non-native writing skill, as evidenced by composite and sub-scale scores on the ESL Composition Profile (Jacobs et al., 1981). Formulaic language was operationalized as 25 three-word strings sampled from the writing sub-list of the Academic Formulas List (Simpson-Vlach & Ellis, 2010) and further validated as frequent in the Michigan Corpus of Upper Level Student Papers. The target formulaic sequences were divided into three experimental groups representing a low, mid, and high amount of formulaic language. Four advanced non-native writers generated argumentative, …

Go to article

The Effects Of Non-Native Species On Two Life-Stages Of The Eastern Oyster Crassostrea Virginica, Wei Yuan Jan 2014

The Effects Of Non-Native Species On Two Life-Stages Of The Eastern Oyster Crassostrea Virginica, Wei Yuan

Electronic Theses and Dissertations

Since their recent introductions into Florida waters, three nonnative species [Perna viridis Linnaeus, 1758 (Asian green mussel), Mytella charruana d'Orbigny, 1846 (charru mussel) and Megabalanus coccopoma Darwin, 1854 (pink titan acorn barnacle)] have expanded both north and south along the Atlantic coast. Very little research has been done to understand how these nonnative species interact with the native eastern oyster (Crassostrea virginica Gmelin, 1791), which is a keystone species that provides important ecological services and economic benefits. To test the potential effects of P. viridis, M. charruana and M. coccopoma on C. virginica, I addressed the following questions: 1a) Does …

Go to article

Modulation Of Cholera Toxin Structure And Function By Host Proteins, Helen Burress Jan 2014

Modulation Of Cholera Toxin Structure And Function By Host Proteins, Helen Burress

Electronic Theses and Dissertations

Cholera toxin (CT) moves from the cell surface to the endoplasmic reticulum (ER) where the catalytic CTA1 subunit separates from the holotoxin and unfolds due to its intrinsic thermal instability. Unfolded CTA1 then moves through an ER translocon pore to reach its cytosolic target. Due to the instability of CTA1, it must be actively refolded in the cytosol to achieve the proper conformation for modification of its G protein target. The cytosolic heat shock protein Hsp90 is involved with the ER-to-cytosol translocation of CTA1, yet the mechanistic role of Hsp90 in CTA1 translocation remains unknown. Potential post-translocation roles for Hsp90 …

Go to article

First Prev Next Last