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Development Of Degraders To Target Oncogenic Proteins And Efforts Towards The Total Synthesis Of Lycopodium Alkaloids Via Oxidative Dearomatization, Yujia Bian

Graduate Thesis and Dissertation post-2024

This dissertation focuses on the degradation of SOS1, a guanine nucleotide exchange factor upstream of KRAS, as an alternative therapeutic target for KRAS‑mutant colorectal cancer (CRC). Guided by crystal structures of SOS1 and cereblon, we designed and synthesized a series of PROTACs based on quinazoline‑linker‑lenalidomide hybrids. Among these, the lead degrader induced up to 92% degradation of SOS1 in CRC cell lines and patient‑derived organoids (PDOs), with excellent specificity. In parallel, an AICAR‑derived PROTAC targeting the transmembrane oncoprotein MUC1‑CT in EGFR‑mutant lung cancer achieved time‑dependent and partial target degradation, establishing complementary chemical tools to probe intracellular signaling and …

The Global Thermophysical Properties Of (433) Eros, Mary L. Hinkle

Graduate Thesis and Dissertation post-2024

We present results from a shape-based, rotationally-resolved thermophysical model of near- Earth asteroid (433) Eros, using reflected and near-IR spectra collected at the NASA Infrared Telescope Facility (IRTF) over 18 nights (25 disk-integrated spectra in total) from 2009-2019. The data sample a variety of viewing geometries, illumination angles, and rotational phases and therefore allow us to characterize Eros's surface physical properties in detail, particularly at wavelengths in the thermal near- IR regime (λ > 3.5 microns) that were not measured by the NEAR Shoemaker mission. Eros's shape, spin state, density, albedo, and other physical properties measured by NEAR were incorporated into …

Field-Resolved Metrology For Attosecond Timing, Christopher A. Lantigua

Graduate Thesis and Dissertation post-2024

Ultrashort pulses of light have opened new frontiers in both fundamental science and applied technology. The short duration and large bandwidth of these pulses has enabled time-resolved spectroscopy of atomic and molecular dynamics at their natural timescales, allowing direct observation of ultrafast processes in these systems which is essential to our fundamental understanding of material behavior. Alongside these optical developments, free-electron lasers (FELs) have advanced the generation of attosecond X-ray pulses. These state-of-the-art facilities allow scientist to probe even deeper into the atomic nature of matter. To access these dynamics, pump-probe experiments are run in which a short optical pulse …

Terahertz Spin Pumping In Antiferromagnetic Crystals And Films, Gregory Fritjofson

Graduate Thesis and Dissertation post-2024

Antiferromagnetic spintronics is a budding field, promising applications for next generation computing and telecommunication, due to the inherent stability and terahertz frequency magnetic dynamics which antiferromagnets (AFMs) possess. However, due to the infancy and uniqueness of the field, AFM spin dynamics have yet to be studied to their full extent in the terahertz range. To this end, we describe a custom magnetometry system with continuous frequency operation from 60 GHz to 1.5 THz, complete quasi-optical polarization control, peak magnetic field of 9 T, temperature control from 5-300 K, and three-axis sample rotation. We provide initial results from uniaxial AFM MnF2 …

Sub-Cycle Nonlinear Optics In Solids, Dipendra Khatri

Graduate Thesis and Dissertation post-2024

The rapid advancement of digital electronics and telecommunication systems necessitates processing information at increasingly higher speeds. However, modern semiconductor technology faces fundamental physical limitations in transistor miniaturization and clock frequency due to quantum mechanical constraints. To overcome these barriers, ultrafast optoelectronics, leveraging light-matter interactions, offers a promising alternative. Light, as the fastest carrier of information, enables signal processing at frequencies far beyond conventional semiconductor technology. Advancements in laser technology have enabled stable and reliable ultrashort light pulse sources, lasting only a few femtoseconds at optical wavelengths. When utilized for signal processing, they could enable clock frequencies over 1000 times higher …

Optomechanical Interactions And Dynamics In Nanoparticle Systems, Sohila Abdelhafiz

Graduate Thesis and Dissertation post-2024

This dissertation investigates the coupling between optical forces and the dynamics of nanoparticle systems. Using theoretical models, simulations and experiments, we explore how light mediates interactions between nanoparticles leading to optical binding, nonreciprocal forces, and collective behavior in colloidal suspensions.

We first examine the dynamics and interactions of particles under illumination due to complex electromagnetic forces. Of particular interest are interparticle forces between particles with specific optical properties such as those satisfying the Kerker scattering conditions. We demonstrate the wavelength-dependent dynamics of such Kerker dimers and establish conditions required for their stable longitudinal binding. We also describe a one-way non-reciprocal …

Numerical Solutions For Deterministic And Stochastic Partial Differential Equations And Effective Integral Evaluation, Guanqian Wang

Graduate Thesis and Dissertation post-2024

This thesis explores advancements in numerical methods, focusing on their applications to some classes of PDEs, Stochastic PDEs (SPDEs), and integral evaluations. The first part of this proposal provides algorithms for computing the mean curvature flow, including cases with topological changes. We propose energy-penalized and multilevel minimization algorithms. Benchmark problems with random initial conditions reveal that small changes in interaction length led to different solution patterns under topological changes. Our methods demonstrate robustness and efficiency, even with poor initial guesses, making them suitable for a wide range of scenarios.

The second part of this proposal introduces a new approach for …

Advanced Subspace Estimation Techniques For Statistical Analysis And Machine Learning, Kang Li

Graduate Thesis and Dissertation post-2024

The rapid expansion of data volume and complexity across diverse domains has underscored the need for robust and efficient techniques capable of extracting meaningful information from high-dimensional datasets. Subspace estimation—identifying the underlying low-dimensional structures within high-dimensional data—has emerged as a cornerstone method in modern data analysis and machine learning. This dissertation aims to advance both the theoretical and practical aspects of subspace estimation problems.

In the first part, we investigate Fréchet central subspace estimation, a critical component of sufficient dimension reduction (SDR) challenges. Traditional SDR methods often fall short when dealing with non-Euclidean responses. To address this, we propose a …

The Benefit Of Benefits: The Role Of Fringe Job Benefits On The Recruitment Of Deskless Workers, Hannah A. Crandell

Graduate Thesis and Dissertation post-2024

Research indicates that the advertisement of fringe job benefits are related to positive job seeker perceptions of the organization and job pursuit intentions. Drawing from Conservation of Resources Theory, I investigate how different types of fringe benefits related to people’s motivations to obtain, enhance, or retain resources differentially attract them to an organization. The study also examines the role of financial well-being as a moderator of fringe benefits and anticipated organizational support. Further, I assess the relationship between fringe benefits and job pursuit intentions through the serial mechanisms of anticipated organizational support and organizational attractiveness. Findings suggest that fringe benefits …

The Impact Of Virtual Backgrounds In Video-Mediated Selection And The Role Of Candidate Qualifications, Mira Gruber

Graduate Thesis and Dissertation post-2024

Videoconferencing allows users to manage their self-presentation through virtual backgrounds that mask their immediate physical environment. Prior research suggests that backgrounds depicting professional home spaces (e.g., bookshelves) elicit more favorable impressions than those that depict personal home spaces (e.g., bedrooms). Expectancy Violations Theory (EVT) provides a framework for understanding such effects. The present dissertation applied EVT to video-mediated selection interviews, that have become increasingly popular since the COVID-19 pandemic. Given the strict expectations for professionalism in interviews, virtual backgrounds that deviate from such expectations may negatively impact hiring decisions. Consequently, this work examined the impact of two virtual background types, …

Retirement Adjustment: Subjective And Social Well-Being Of Retirees In Response To The Preretirement Work-Nonwork Interface, Yeeun Choi

Graduate Thesis and Dissertation post-2024

Retirement represents a significant life transition that profoundly impacts one’s subjective and social well-being. Drawing on the life course perspective, this study investigated retirement adjustment by analyzing the longitudinal patterns of well-being and the predictors influencing these trajectories. Using a mixed-methods approach, this study combined 16 years of longitudinal data from the Health and Retirement Study (HRS) (n_A = 1,470, n_B = 1,422) with qualitative narratives from retirees (n = 30) to provide a comprehensive understanding of the retirement adjustment process. The growth mixture model (GMM) analysis identified four distinct patterns in retirees' life satisfaction trajectories …

Sexual And Gender Minority Identity Acceptance And The Role Of Florida Legislation Perception On Medical Disclosure And Risky Health Behaviors, Aubrianna L. Stuckey

Graduate Thesis and Dissertation post-2024

Recently, across the United States, efforts have been made to remove protective legislation and resources surrounding the sexual gender minority (SGM) community (Woodford et al., 2018). Given how quickly Florida’s HB 1557 legislation was passed and the corresponding, ongoing attempts to expand the bills, there is limited research exploring the role of legislative change on SGM communities. Newer literature indicates that discriminatory laws or bills have impacted the mental health of the SGM community, especially among SGM adolescent and young adults ; however, research exploring the role legislation has on SGM individual’s physical health, requires further investigation(American Psychological Association, 2023; …

Burnout In The Workplace- Organizational Influences On Counselor Burnout, Serene Hasan

Graduate Thesis and Dissertation post-2024

This study is a two-part manuscript dissertation that examined the impact of the six organizational influencers of burnout: Workload, Control, Reward, Community, Fairness, and Values on mental health counselors’ (MHCs) burnout, using Maslach’s three subscales of burnout: Emotional Exhaustion, Depersonalization, and Personal Accomplishment. Additionally, Work Setting and Age were assessed for their influence on MHC burnout, when the six organizational influencers were accounted for. The focus on this topic is crucial as burnout has a detrimental effect on counselors, clients, and organizations. The growing population in need of support surpasses the amount of MHCs that our nation has to offer. …

An Involuntary Motive Of Voluntary Behavior: An Investigation Of The Causes And The Consequences Of Citizenship Pressure, Junyoung Hong

Graduate Thesis and Dissertation post-2024

This dissertation investigates citizenship pressure, defined as an individual’s perception of pressure to perform organizational citizenship behavior (OCB), by examining its conceptual boundaries, antecedents, behavioral outcomes, and underlying mechanisms. Study 1 used an item-sorting task with undergraduate participants to assess whether citizenship pressure is empirically distinct from related constructs such as OCB norms and workaholism. Substantial conceptual overlap prompted refinement of the construct and its measurement. Study 2 surveyed employees to examine how supervisor and coworker OCB demands, along with personality traits (conscientiousness and agreeableness), predict citizenship pressure at the between-person level. Although personality traits showed no direct effects, they …

Impacts Of Susceptibility To Peer Influence And Fomo On Viewing Alcohol-Related Content On Social Media, Alcohol Expectancies, And Alcohol Use, Callie L. Wang

Graduate Thesis and Dissertation post-2024

PURPOSE: Young adult (YA) alcohol use remains a significant public health problem, and may be influenced by alcohol expectancies developed through exposure to peers’ alcohol related content (ARC) on social media. This study examined the associations among ARC exposure, alcohol expectancies and alcohol use among YAs, and how susceptibility to peer influence and Fear of Missing Out (FoMO) may influence these relations. METHOD: YAs in the United States who endorsed consuming 1-2 standard drinks per month (N=371) completed surveys measuring ARC exposure, alcohol expectancies, susceptibility to peer influence, FoMO, and alcohol use at baseline and at 4- and 8-week follow …

Confirming The Factor Structure Of The Police Officer Stigma Scale, Daniel R. Horning

Graduate Thesis and Dissertation post-2024

First responders routinely face exposure to critical incidents within the line of duty, resulting in higher prevalence of psychopathological conditions compared to the general population. However, a growing body of research identified a severe underutilization of mental health-related services among this population, with stigma towards mental illness being the most cited barrier to seeking care. Stigma as a construct is being actively measured, but the factor structure of stigma towards mental health remains contested in literature. Optimal model fit for Stuart’s Police Officer Stigma Scale is an example of these empirical debates, as both single-factor and two-factor models are offered …

Men’S Aggressive Responses To Sexual Rejection: The Roles Of Rejection Sensitivity, Alcohol Use, And Perceived Injustice, Cameron A. Davis

Graduate Thesis and Dissertation post-2024

PURPOSE: Sexual rejection can be often associated with an aggressive response. Prior research has identified rejection sensitivity as a risk factor for aggressive behavior, however, it has not been investigated in the context of sexual rejection. Highly rejection sensitive men may attend to negative cues, feel “betrayed,” and respond aggressively, especially after consuming alcohol.Thus, the goal of this study was to investigate the perpetration of aggressive responses to sexual rejection by examining the roles of rejection sensitivity, perceived injustice, and alcohol use in a sample of young adult men. METHOD: Men (n = 447) who endorsed one lifetime …

Identity Impacts Of Crafting In Multiple Life Domains Among Employees With Chronic Mental And Physical Illnesses: A Mixed-Method Study, Kenzie Dye

Graduate Thesis and Dissertation post-2024

This dissertation examined the impact of job, home, and leisure crafting on perceptions of five markers of positive work identity among employees with chronic mental and physical illnesses. It was hypothesized that all forms of crafting would be positively related to work identity perceptions when examined independently, and that job crafting would be the strongest predictor when the crafting categories were examined together. It was also predicted that home and leisure crafting would amplify the effects of job crafting on positive work identity. Based on qualitative data collected from focus groups comprised of individuals with a variety of chronic mental …

Examination Of Driving Experience, Hazard Perception & Distracted Driving: Going Beyond Individual Factors By Using A Social-Ecological Framework, Alejandro A. Arca

Graduate Thesis and Dissertation post-2024

This research included two studies that examined the roles of nomophobia, driving experience, distraction presence, and hazard presence on driving behavior. In Study 1, a hazard perception task was used to assess participants’ hazard perception accuracy rate and reaction time. Results showed that novice drivers displayed significantly higher levels of nomophobia and lower self-efficacy scores, divided attention, and working memory scores compared to their experienced counterparts. Furthermore, the results also showed that novice drivers reported faster reaction times to hazards, which may be associated with poor impulse control as previously reported in the literature. Study 2 was conducted to further …

Firefighter Syndrome: Improving The Identification And Classification Of Firefighters In Need, Michael A. Schlenk

Graduate Thesis and Dissertation post-2024

Firefighters (FFs) exhibit a multitude of behavioral and physical health concerns as well as fluctuating social support due to their occupation. Despite the fire service enacting preventative approaches to health and wellness, FFs still report increased prevalences of health concerns at the end of their career. Firefighter syndrome was created to identify FFs in need of medical care (e.g., behavioral and physical health services, Frueh et al., 2022b). The purpose of this study is to validate the construct of FF Syndrome by using statistical classification techniques to investigate whether there is a latent group of firefighters that have the symptoms …

The Role Of Substance Use And Objectification On Bisexual Women’S Sexual Violence Experiences, Rachel Cooper

Graduate Thesis and Dissertation post-2024

Bisexual women experience the highest rates of sexual violence victimization, across all tactics, compared to all other gender and sexual orientation groups. Bisexual women’s higher rates of substance use puts them at greater risk for substance-facilitated sexual violence, however this does not account for higher rates of sexual violence that happen through other tactics. Objectification theory states that people learn to view women as sexual objects, whose value derives from their bodies’ sexual utility and this view increases the likelihood of sexual violence. Bisexual women experience an additional form of objectification in the form of bisexual stigma which is characterized …

Leading The Newsroom: Exploring The Development Of Management And Leadership Skills In College Journalism Students, Guilherme Hiray Leal

Graduate Thesis and Dissertation post-2024

The purpose of this study is to examine the management and leadership skills that are developed in college journalism and how that experience and training prepares students for the challenges of reporting for, managing, and leading in today’s journalism businesses. I explored leadership (e.g. influence in the newsroom culture) of young journalists in student media, such as what skills are being emphasized by their advisers. This study utilizes gatekeeping theory to connect its main points with leadership-related characteristics. Findings show that the support and training students in student media receive are more directly related to management as opposed to leadership. …

Applying The 5d Model Of Country Image For International Public Relations: Analyzing Cultural Perceptions Of Qatar’S International Events "Expo 2023", Taleb Al-Adbah

Graduate Thesis and Dissertation post-2024

Studying country image in public relations has become essential to developing practices for countries engaging with international audiences. Hosting international events highlights the need for international public relations, where the country must adapt its culture and create culturally sensitive strategies to communicate effectively with individuals from diverse cultural backgrounds (Edwards, 2018). In this dissertation, Expo 2023 was employed as an international event to analyze Qatar’s country image among foreign and Qatari audiences. The dissertation aimed to understand the differences between their perspectives on Qatar and determine whether cultural tendencies impacted the country’s image. Additionally, the relationship between intercultural competency and …

Nursing Simulation For Pediatric Communication: An Integrative Literature Review, Jayla R. Call

Honors Undergraduate Theses

The aim of this thesis is to explore literature focused on enhancing nursing students' communication skills with pediatric patients through simulation. Effective communication is key to building rapport and trust, which are essential for improving patient outcomes. However, nursing students may experience anxiety when interacting with pediatric patients due to limited training in communication techniques. Simulation offers a valuable opportunity for students to practice and refine their skills in a risk-free environment, allowing them to build confidence and competence. An integrative literature review was conducted, utilizing three databases and PRISMA guidelines (Page et al., 2021) to gather relevant studies for …

The Impact Of Socioeconomic Status On Substance Use Amongst The Hispanic Maternal Population, Emily C. Olivo

Honors Undergraduate Theses

Aim: To explore and synthesize existing research that focuses on the relationship between socioeconomic status and the use of substances amongst the maternal Hispanic population. By examining research and these factors, interventions can be identified to lower reported substance use rates amongst Hispanic mothers of childbearing ages.

Background: Minorities such as Hispanic women deal with a myriad of struggles, especially during motherhood. Socioeconomic status and substance use can contribute to a large part of the struggles faced by this population. Hispanic and Latina will be used interchangeably throughout this review of literature.

Method: A comprehensive electronic review of 3 databases …

Organization And Activation Of Caffeine Expectancies, Catherine S. Forsyth

Honors Undergraduate Theses

Caffeine is the most consumed and widely used psychoactive substance in the world. Whether someone uses caffeine or not, expectations about use can be influential to some degree. Expectancies exist everywhere and are extremely influential in all aspects of life. Regarding drug use, expectancies can affect behavior, outcomes, and one’s experience with the drug. Caffeine is no exception, caffeine expectancies have been seen to play a role in several actions such as the development, maintenance, and reinforcement of caffeine use. This study examined latent use profiles of caffeine and relationships between the profiles and the activation of caffeine expectancies. Multidimensional …

Remedios Varo: Peregrinaciones, Julia Condes

Honors Undergraduate Theses

At the time of her death, the artist Remedios Varo (1908–1963) left behind over 500 works of art, the majority of which were created in her adopted country of Mexico. Known for her meticulously crafted fantastical paintings, Varo underwent exile and displacement due to first the Spanish Civil War, and later World War II, which led her to relocate to Mexico, where she would create prolifically for the remainder of her life. This paper will examine the effect of those experiences on the artist and the work she produced, attesting to Varo’s ability to translate complex emotions regarding the human …

Community Redevelopment Agencies' (Cras) Perceptions Of The Legal, Ethical, Economic, And Financial Impacts On Florida's Redevelopment Since The Passage Of Florida House Bill 9 In 2019, Laurel L. Richmond

Honors Undergraduate Theses

This qualitative study explores the legal, ethical, economic, and financial impacts on Community Redevelopment Agencies (CRAs) following the passage of Florida House Bill (HB) 9 in 2019 by interviewing administrators and attorneys of the oldest Florida CRAs. CRAs are dependent special districts, funded by tax increment financing (TIF), and created to address areas deemed slum, blighted, or facing a shortage of affordable housing. HB 9 intended to address transparency and accountability issues and restore CRA operations and spending back to the original purpose, as authorized by Florida Statute 169.

The findings are timely and novel, given it has been five …

Assessing The Relationship Between Perceived Psychological And Physical Pain In Adults With Orthopedic Pain, Daniel C. Karimi Dehkordi

Honors Undergraduate Theses

Suicide remains a public health concern in the U.S., particularly among individuals experiencing chronic pain and psychological distress. This cross-sectional study investigated the relationship between perceived physical and psychological pain in 41 adults with chronic orthopedic conditions. The relationship between other risk and protective factors and perceived levels of pain distress was also examined. Results showed a significant positive correlation between psychological distress and physical pain (r(39) = 0.388, p < .05) and psychological distress and depressive/anxiety symptoms (r (39) = 0.477, p < .01). Psychological distress was moderately associated with feelings of hopelessness (r (39) = 0.403, p < .01), however, the relationship between physical pain and hopelessness was weak and nonsignificant (r (39) = -0.06, p = .71). Contrary to expectations, emotional support did not buffer the effects of psychological distress (r (39) = 0.07, p = 0.66). Mediational analysis confirmed that emotional support did not influence the relationship between physical pain and psychological distress (Beta (β) = -0.969, p = 0.572; Sobel Z = 0.5598, p = 0.575). Age was not correlated with psychological distress (r (39) = -0.24, p = 0.13) or mental health symptoms (r (39) = -0.05, p = .77). While there was no significant difference across sex, males reported higher mental health symptomatology and psychological distress scores than female counterparts. These findings underscore the direct impact of physical pain on psychological distress and challenge assumptions about the protective role of social support. The study highlights the need for integrated, multidisciplinary interventions targeting both physical and psychological pain to mitigate suicide risk among individuals with chronic orthopedic conditions. Future research should iii explore alternative support mechanisms and resilience-building strategies to address the complex interplay of pain, distress, and suicidality.

Intelligent Tutoring Systems In The Age Of Llm-Based Agentic Frameworks - Adapting Small On-Device Language Models For Fact-Checking And Student Compliance Detection, Evan Vahid Naderi

Honors Undergraduate Theses

As large language models (LLMs) demonstrate increasingly sophisticated language understanding capabilities, they offer transformative potential for educational technology, particularly in developing more responsive intelligent tutoring systems (ITS). To develop these systems, a synthesis that balances theoretical frameworks with practical, cutting-edge, and deployable technology would be useful. This thesis aims to advance the field of ITSs theoretically by viewing the modern advancements in natural language processing within the context of the foundational frameworks important to the fields of self-regulated learning, ITSs, and cognitive agents. Then, building on prior research on the ITS MetaTutor \citep{Azevedo2022}, this research focuses on how functions of …