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Investigation Of The Cell-Cycle Dependent Activity Of The Brca1-Rbbp8 Complex For Homologous Recombination, Jil Shah Jan 2019

Investigation Of The Cell-Cycle Dependent Activity Of The Brca1-Rbbp8 Complex For Homologous Recombination, Jil Shah

Honors Undergraduate Theses

When cells undergo mitosis, they must replicate all six billion base pairs of DNA within the nucleus. With the sheer volume of information, it is impossible to replicate with 100% accuracy each time. Homologous recombination (HR) is one of many mechanisms the body has developed to correct and repair replication errors to DNA. HR is specific to double-stranded breaks to DNA, and it requires a sister chromatid to preserve the genetic code. BRCA1 and Rbbp8 interact to form a complex that is heavily involved in this process. Although there is a strong consensus about the involvement of these proteins in …

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Don't Worry: A Personal Documentary Of My Grandmother And An Exploration Of Themes Of Motherhood, Loneliness, And Later Life, Olivia A. Wilson Jan 2019

Don't Worry: A Personal Documentary Of My Grandmother And An Exploration Of Themes Of Motherhood, Loneliness, And Later Life, Olivia A. Wilson

Honors Undergraduate Theses

The intent for this thesis is to to explore the ideologies of my grandmother and to learn from them. I do so by filming and editing a documentary with Grandma serving as my subject. She is a woman who has been very present in my life and who has lived and bestowed so much upon me that I still remain wanting more. I wish to know much more of her mind now than I did as a child of simpler times and ponderings. I have spent close to a year shooting and assembling this film that explores the nature of …

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Split Probe Detection Of The Influenza A Virus For Improved Diagnostics In A Point Of Care System, Tamar Yishay Jan 2019

Split Probe Detection Of The Influenza A Virus For Improved Diagnostics In A Point Of Care System, Tamar Yishay

Honors Undergraduate Theses

A group of Influenza viruses, RNA containing viruses of the Orthomyxoviridae family, consists of Influenza virus types A-D and has been known to cause the Flu, a respiratory illness associated with numerous detrimental symptoms that can lead to death. Influenza A virus (IAV) is constantly changing and is capable of causing pandemics. Currently used diagnostic methods include virus culturing, immunoassays including rapid influenza detection tests (RIDTs), and molecular assays including those based on RT-PCR. Most of the methods can be only performed in the certified diagnostic laboratories equipped with sophisticated instrumentation and/or special biosafety facilities. The results using these methods …

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Academic Competence, Self-Efficacy, And Achievement Expectations Among International Students At The University Of Central Florida, Emily Hynson Jan 2019

Academic Competence, Self-Efficacy, And Achievement Expectations Among International Students At The University Of Central Florida, Emily Hynson

Honors Undergraduate Theses

With the vast and continued growth of international students in the U.S., it is important to focus on this expanding group and identify factors that aid or hinder academic performance, achievement, expectations, and competence. Factors known to affect academics among international students, such as language barriers, acculturation to American society, university support and structure, social integration at the university, family support, and motivating factors to study in the U.S were examined. It was hypothesized that these known factors would negatively correlate with the academic outcomes of international students examined in the current study. It was also hypothesized that these factors …

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The Effect Of Corporate Social Responsibility On Firm Value And Performance, Jennifer E. Maxey Jan 2019

The Effect Of Corporate Social Responsibility On Firm Value And Performance, Jennifer E. Maxey

Honors Undergraduate Theses

In this thesis, I test the effects of corporate social responsibility (CSR) on firm valuation and performance from the financial crisis of 2007 to year 2013. Prior research on CSR suggests that CSR is related to firm performance, but the results have not been consistent. My study focuses on the time period following the crisis since trust between firms and stakeholders may be more important following a negative shock. The components of CSR are broken out into environmental, human rights, diversity, community impact, employee relations, product, and corporate governance. I find evidence that at least some measures of firm performance …

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Effect Of Propionic Acid-Derivative Ibuprofen On Neural Stem Call Differentiation; A Potential Link To Autism Spectrum Disorder, Aseelia Samsam Jan 2019

Effect Of Propionic Acid-Derivative Ibuprofen On Neural Stem Call Differentiation; A Potential Link To Autism Spectrum Disorder, Aseelia Samsam

Honors Undergraduate Theses

Propionic acid (PPA) is a short chain fatty acid that is produced by the human gut microbiome. Propionate, butyrate and acetates are the end products of the fermentation of the complex carbohydrates by human gut friendly microbiome and are being used as sources of energy in our body. PPA is used as a food preservative against molds in various daily products and has been implicated in the pathogenesis of autism. In a recent study we showed that PPA in human neuronal stem cell (NSC) culture increases the astrocyte population and decreases the neuronal number and increases the inflammatory cytokines. In …

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An Analysis Of Obstacles To Peace Between Iran And Israel, Emily M. Aspinwall Jan 2019

An Analysis Of Obstacles To Peace Between Iran And Israel, Emily M. Aspinwall

Honors Undergraduate Theses

The history of confrontation and cooperation between Iran and Israel is a volatile sequence. With the transformative impact of the 1979 Iranian Revolution on Iranian leadership and ideology, as well as Israel’s metamorphosis from a newly independent state to a regional rival, there is much to unpack in this relationship. From regime changes to nationalistic awakenings, Iran and Israel’s conflict is comprised of infinite layers brimming with historical and political implications. For the past 70 years, Iran and Israel’s diplomatic relationship has encountered numerous shifts, thus forming an axis of hostility, regional contention, and damaging rhetoric. This research analyzes the …

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A New Measure Of The Authoritarian Personality: Untangling The Personal And The Political, Melodie Spiegel Jan 2019

A New Measure Of The Authoritarian Personality: Untangling The Personal And The Political, Melodie Spiegel

Honors Undergraduate Theses

Despite the existence of multiple scales designed to measure authoritarianism as a personality trait, current research disagrees as to whether current measures reliably measure all three dimensions of authoritarianism: submission, aggression, and traditionalism. This study focused on the development of a new scale in response to methodological and validity concerns of previously-used measures. This new scale was found to be a reliable measure of authoritarian belief in two subsequent studies of college-aged adults. Factor analysis of responses to the items of the new measure also provided evidence of the multidimensionality of authoritarianism as a construct. Further, significant correlations were found …

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Barriers To Healthcare For The Transgender Population: A Focus On The Trans Persons' Experience Accessing Healthcare Services, Bryce E. Harrison Jan 2019

Barriers To Healthcare For The Transgender Population: A Focus On The Trans Persons' Experience Accessing Healthcare Services, Bryce E. Harrison

Honors Undergraduate Theses

Background: Transgender people face several barriers to healthcare when accessing services. Purpose: The purpose of this study was to explore the lived-experience of the transgender person accessing healthcare. Methods: Colaizzi phenomenological method was used to delve into the experience. The guiding question was: What is the lived experience (challenges, barriers, and/or difficulties) that the transgender person experiences when accessing healthcare? Results: Initial themes were collapsed to create relevant meanings. Five themes emerged from the protocols and were validated by participants. Overall, the transgender person is vulnerable in the healthcare system due to the lack of representation of their identity, which …

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Role Of Amyloid Precursor Protein In Neuroregeneration On An In Vitro Model In Alzheimer's Patient-Specific Cell Lines, Lina S. Bedoya Martinez Jan 2019

Role Of Amyloid Precursor Protein In Neuroregeneration On An In Vitro Model In Alzheimer's Patient-Specific Cell Lines, Lina S. Bedoya Martinez

Honors Undergraduate Theses

Alzheimer's disease (AD) leads to neurodegeneration resulting in cognitive and physical impairments. AD is denoted by accumulation of intracellular neurofibrillary tangles, known as tau, and extracellular plaques of the amyloid beta protein (Aβ). Aβ results from the proteolytic cleavage of the amyloid precursor protein (APP) by β- and gamma-secretases in the amyloidogenic pathway. Although, Aβ has been widely studied for neurodegeneration, the role of APP in both, the healthy and diseased conditions, has not yet been entirely understood. The function that APP has in neural stem cell (NSC) proliferation, differentiation, and migration during adult neurogenesis has been previously studied. Additionally, …

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Willingness To Communicate And International Students' Use Of L2, Michelle Verbitskaya Jan 2019

Willingness To Communicate And International Students' Use Of L2, Michelle Verbitskaya

Honors Undergraduate Theses

Willingness to Communicate (WTC) in the second language (L2) is the "readiness to enter into discourse" which is considered to be the direct precursor of students' communication in L2 (MacIntyre et al., 1998). Oral language is thought to precede written language which creates an assumption that ongoing refining of oral skills may impact writing fluency. In respect to WTC model, there have been several versions that describe the construct (MacIntyre et al., 1998; Wen & Clement, 2003; Matsuoka, 2006). This study references self-efficacy, a cognitive variable in Matsuoka's (2006) proposed model, when analyzing writing as a phenomenon in relation to …

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Recruit Quality And College Football Team Performance In The Cfp Era, Jordan Aaron Izenwasser Jan 2019

Recruit Quality And College Football Team Performance In The Cfp Era, Jordan Aaron Izenwasser

Honors Undergraduate Theses

Recruiting is a major component of college football. Teams compete for recruits since the quality of a recruiting class contributes to on-field success. Previous studies have investigated the relationship between recruit quality and on-field performance and have found that a positive relationship exists. This thesis contributes to the literature by empirically examining how recruit quality affects team performance in the College Football Playoff (CFP) era using various measures of success. Panel data econometric models are used to determine the effect of recruits between schools, as well as within both conferences and schools on team performance. It also considers the validity …

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Current Perceptions Of Undocumented Immigrants In The United States, Gabriela Lozano Jan 2019

Current Perceptions Of Undocumented Immigrants In The United States, Gabriela Lozano

Honors Undergraduate Theses

The intent of this thesis is to examine current perceptions that U.S. Americans have about immigrants coming to the U.S. illegally/ undocumented. There is currently an ongoing debate around immigration in today's political climate. Historically, immigration has always happened in the U.S. and has sparked a vast array of feelings from the U.S. population (Obinna 2018). This study aims to contribute to the existing literature on undocumented immigration to the U.S. and opinion surrounding it. The current study uses the opinion of 177 people to compare current perceptions of undocumented people based on gender, income, and political standing. This study …

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Health Literacy And Health Information Seeking Behaviors Of Student At The University Of Central Florida, Abigail Mcwhorter Jan 2019

Health Literacy And Health Information Seeking Behaviors Of Student At The University Of Central Florida, Abigail Mcwhorter

Honors Undergraduate Theses

Health literacy is the skill needed to acquire, read, understand, and use health related information to make informed healthcare decisions. It is also the skill needed to follow and maintain a treatment plan. Having a high or adequate health literacy level is important because possessing poor health literacy skill can have a negative impact on one's overall health. This research is important because there are few studies available on the health literacy levels of undergraduate college students. The majority of health literacy studies focus on at risk or underserved populations with low education. Previous studies have shown that education is …

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Female Militarization And Women's Rights: A Case Study Of The Peshmerga And Ypj, Margaret Morgan Jan 2019

Female Militarization And Women's Rights: A Case Study Of The Peshmerga And Ypj, Margaret Morgan

Honors Undergraduate Theses

Since 2012, there has been an increase of media attention on the Kurds, particularly women who are active in the YPJ and Peshmerga. Various publications have equated women's militarization with women's liberation. In an effort to more accurately measure this, the following question must be asked; what is the effect of women's military involvement on women's rights? Women that are active in both nationalist movements and traditional state armies are presented with changing gender roles. Post conflict, there is a struggle for women to transfer their newfound autonomy into political activism. The theory outlines a chain in which women participate …

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Measuring Media Multitasking, Alexandria Trombetta Jan 2019

Measuring Media Multitasking, Alexandria Trombetta

Honors Undergraduate Theses

This study aimed to document the occurrence of media multitasking activity, as well as to explore a possible typology of which media tasks will be distinguished as primary or secondary in a multitasking situation, which primary tasks are most often combined with a secondary task, and what secondary tasks are most likely to be paired with a given primary task. An original questionnaire was developed to collect data on media tasks commonly paired in multitasking situations as well as the reasons for or perceived benefits of pairing these tasks. This questionnaire was given to participants along with several individual differences …

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The Envelope Stress Response In Sedimentation-Resistant Escherichia Coli, Neel K. Shah Jan 2019

The Envelope Stress Response In Sedimentation-Resistant Escherichia Coli, Neel K. Shah

Honors Undergraduate Theses

Previous research discovered the existence of sedimentation-resistant mutants of E. coli. Genomic studies revealed that these mutants resisted sedimentation due to independent modifications to genes that influenced the Rcs signal transduction pathway, causing increased secretion of an exopolysaccharide capsule comprised primarily of colanic acid. The Rcs system is responsible for detecting envelope stressors; consequently, ampicillin and osmotic stress were used to perturb the cellular envelope and study the response of the mutants compared to wild-type cells. It was found that the overproduction of colanic acid in the mutants confers some resistance to envelope stress; however, the mutants still behaved …

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Overview Of Direct Thrombin Inhibitors For Use In Staphylococcus Aereus Infections, Joseph C. Risler Jan 2019

Overview Of Direct Thrombin Inhibitors For Use In Staphylococcus Aereus Infections, Joseph C. Risler

Honors Undergraduate Theses

The pathogenicity and intractable nature of the microorganism Staphylococcus aureus (SA) has been long documented and highlighted by many health care agencies, with emphasis on its ability to exploit the human coagulation system to deadly effect. Two drugs from a class of inhibitors known as Direct Thrombin Inhibitors (DTI) have been shown to have a substantial effect on the enzyme secreted by SA known as Staphylocoagulase (SC), but up until now the application of this potential treatment has been limited. This paper strives to supply an overview of these clinical studies and propose a novel protocol for testing DTI's on …

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Standing Up Comedy: Analyzing Rhetorical Approaches To Identity In Stand-Up Comedy, Christopher Grabert Jan 2019

Standing Up Comedy: Analyzing Rhetorical Approaches To Identity In Stand-Up Comedy, Christopher Grabert

Electronic Theses and Dissertations

My thesis addresses contemporary conversations about stand-up comedy and the art-form's capacity for facilitating complex rhetorical decision-making. I examine how stand-up comedians have positioned themselves on-stage through choices pertaining revealing personal behaviors, personas, and beliefs in public settings. Ultimately, I argue that the art of stand-up does not require truth-telling on-stage, and that there exists an implicit contract between performers and audiences which details comedians' license to share falsehoods, exaggerations, and embellishments on-stage without the repercussions that accompany these actions in other discourse settings. Finally, I evaluate how comics have handled this rhetorical "license," with some performers delivering easily identifiable …

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University Of Central Florida Libraries, Annual Report 2018-2019, University Libraries Jan 2019

University Of Central Florida Libraries, Annual Report 2018-2019, University Libraries

Libraries' Documents

No abstract provided.

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Characterization Of Rare-Earth Doped Thermal Barrier Coatings For Phosphor Thermometry, Quentin Fouliard Jan 2019

Characterization Of Rare-Earth Doped Thermal Barrier Coatings For Phosphor Thermometry, Quentin Fouliard

Electronic Theses and Dissertations

Thermal Barrier Coatings have been extensively used to protect and insulate the metallic components in turbine engines from extreme environments to achieve higher turbine inlet temperatures, resulting in an increase in combined engine cycle efficiency, lowering NOx emissions and fuel consumption. Additionally, as the major failure mechanisms determining lifetime are thermally activated during engine operation, uncertainty in temperature measurements affects lifetime prediction. Early detection of Thermal Barrier Coatings spallation symptoms, associated with local delamination induced temperature changes, can reduce forced engine outages. Further improvements are envisioned with the development of more reliable measurement techniques. For this purpose, Phosphor Thermometry has …

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The Efficacy Of Meditation-Based Treatments In Relapse Prevention For Persons With Substance Use Disorders, Florence C. Bates Jan 2019

The Efficacy Of Meditation-Based Treatments In Relapse Prevention For Persons With Substance Use Disorders, Florence C. Bates

Honors Undergraduate Theses

Substance abuse is a global problem that has contributed to a variety of societal, financial, health, and familial strains. An increasing prevalence of illicit drug, prescription opioids, and alcohol abuse has created a need for re-evaluation of recovery and relapse treatments. This literature review examines the efficacy of meditation-based treatments for relapse prevention in persons recovering from Substance Use Disorders (SUDs). A comparative analysis of Mindfulness Based Relapse Programs (MBRP), an adapted MBRP-W program, and a Transcendental Meditation (TM) intervention was used to examine the success of meditation-based interventions. Research supports improvements associated with the meditation-based interventions including significant reductions …

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Factors Contributing To The Negative And Unhealthy Psychological Conditions In The Ed Rn, Ariana M. Nieves Jan 2019

Factors Contributing To The Negative And Unhealthy Psychological Conditions In The Ed Rn, Ariana M. Nieves

Honors Undergraduate Theses

The emergency department is a stressful environment. Emergency department registered nurses (ED RNs) are at an increased risk of development of negative and unhealthy psychological conditions due to their frequent exposure to stress and traumatic events. These conditions include post-traumatic stress disorder, compassion fatigue, and burnout syndrome, which are already known to be common in the emergency department registered nurse population. It is important to understand the factors that influence the development of these psychological conditions in order to provide better education to nurses regarding prevention of the development of these psychological conditions. This literature review aimed to identify articles …

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Mechanism Of Nanogp8 In Glioblastoma Multiforme, Jonhoi Smith Jan 2019

Mechanism Of Nanogp8 In Glioblastoma Multiforme, Jonhoi Smith

Electronic Theses and Dissertations

Glioblastoma multiforme (GBM) is an incurable brain tumor, with patients only expecting to live 15 to 16 months post-diagnosis with the most current treatments options including surgery, chemotherapy, and radiation. How GBM resist treatment is still not very well known. However, cancer stem cells (CSCs), a subset of cells in GBM tissue considered responsible for therapeutic resistance and the poor patient prognosis. NANOG, a homeobox gene, is responsible for maintaining pluripotency of embryonic stem cells and is observed in CSCs. NANOGP8, a retrogene in the NANOG family is expressed in CSCs and provides cells with stem-like characteristics previously observed in …

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Identification And Functional Characterization Of A Long Non-Coding Rna Associated With Prostate Cancer, Md Faqrul Hasan Jan 2019

Identification And Functional Characterization Of A Long Non-Coding Rna Associated With Prostate Cancer, Md Faqrul Hasan

Electronic Theses and Dissertations

Prostate cancer is the most common cancer in men in the western world. Although early stage prostate cancer is treatable late stage, more specifically, metastatic and drug resistant prostate cancers are mostly incurable. The failure of current treatments obligates the research community to explore novel areas in prostate cancer biology and find better therapeutic targets. Emerging evidences show that non-coding RNAs specifically long non-coding RNAs (lncRNAs) play regulatory roles in various cellular processes and are frequently dysregulated in cancer including prostate cancer. These aberrantly expressed lncRNAs mostly with unexplored genetic information may drive cancer progression. Previous studies done in our …

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Teachers' Perceptions Of Safety Regarding School Shootings, Megan Olive Jan 2019

Teachers' Perceptions Of Safety Regarding School Shootings, Megan Olive

Electronic Theses and Dissertations

As a result of high media attention surrounding school shootings in recent years, it may appear that American public schools are becoming dangerous places (Schildkraut & Elsass, 2016; Elsass, Schildkraut, & Stafford, 2016; Toppo, 2013). Though schools remain to be one of the safest locations for children, various safety measures are discussed and implemented in schools to combat this perceived problem and ensure the safety of school campuses. Discussions of best safety practices spikes directly following a school shooting event from relevant parties, such as school administration, law enforcement agencies, parents, and students, (Crawford & Burns, 2015; Chrusciel, Wolfe, Hansen, …

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Development Of A Functional Testing Platform For The Sensory Segment Of The Neuromuscular Reflex Arc, Alisha Colon Jan 2019

Development Of A Functional Testing Platform For The Sensory Segment Of The Neuromuscular Reflex Arc, Alisha Colon

Electronic Theses and Dissertations

Investigations of human biology and disease have been hindered by the use of animal models. The information obtained from such studies often results in clinically irrelevant results and drug trial failures. Additionally, several governing bodies have been formulating legislation to move away from animal models and toward more ethical and efficient testing platforms for drug discovery and cosmetic research. As an answer to these issues, "body-on-a-chip" systems have been a rapidly developing field which easily recapitulates in vivo functionality, providing a more relevant, repeatable, and ethical testing platform to better predict biology. These systems can be used as human-based testing …

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Women's Page History Author Talk Bookmark, Megan M. Haught Jan 2019

Women's Page History Author Talk Bookmark, Megan M. Haught

Libraries' Documents

No abstract provided.

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Assessing Pedestrian Safety Conditions On Campus, Morgan Morris Jan 2019

Assessing Pedestrian Safety Conditions On Campus, Morgan Morris

Electronic Theses and Dissertations

Pedestrian-related crashes are a significant safety issue in the United States and cause considerable amounts of deaths and economic cost. Pedestrian safety is an issue that must be uniquely evaluated in a college campus, where pedestrian volumes are dense. The objective of this research is to identify issues at specific locations around UCF and suggest solutions for improvement. To address this problem, a survey that identifies pedestrian safety issues and locations is distributed to UCF students and staff, and an evaluation of drivers reactions to pedestrian to vehicle (P2V) warning systems is studied through the use of a NADS MiniSim …

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Design And Implementation Of Silicon-Based Mems Resonators For Application In Ultra Stable High Frequency Oscillators, Sarah Shahraini Jan 2019

Design And Implementation Of Silicon-Based Mems Resonators For Application In Ultra Stable High Frequency Oscillators, Sarah Shahraini

Electronic Theses and Dissertations

The focus of this work is to design and implement resonators for ultra-stable high-frequency ( > 100MHz) silicon-based MEMS oscillators. Specifically, two novel types of resonators are introduced that push the performance of silicon-based MEMS resonators to new limits. Thin film Piezoelectric-on-Silicon (TPoS) resonators have been shown to be suitable for oscillator applications due to their combined high quality factor, coupling efficiency, power handling and doping-dependent temperature-frequency behavior. This thesis is an attempt to utilize the TPoS platform and optimize it for extremely stable high-frequency oscillator applications. To achieve the said objective, two main research venues are explored. Firstly, quality factor …

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