Digital Commons Network^™

The Impact Of Gastric Sleeve And Roux-En-Y Gastric Bypass On Chief Cell Function And Protein Digestion In Obese Patients, Garikoitz Mikel Gainza

Honors Undergraduate Theses

Obesity has become one of the largest global health concerns of the 21^st century, correlating with numerous associated diseases. To help address the growing prevalence and burden of obesity, sleeve gastrectomy and Roux-en-Y gastric bypass have become two commonly performed surgical procedures done to promote weight loss by altering the anatomical structure of the stomach and surrounding organs of the gastrointestinal system. Although the benefits of improved metabolism linked to these surgical procedures are well studied, their impact on the physiology of gastric cells, and more specifically chief cells as they relate to protein digestion post-surgery, is yet to …

Impact Of Senescence On Breast Cancer Outcomes, Gracie Sous

Honors Undergraduate Theses

Cellular senescence is a biological process in which damaged cells exit the cell cycle while remaining metabolically active and accumulating within tissues. Senescence plays a complex role in breast cancer progression, largely through the secretion of senescence-associated secretory phenotype (SASP) factors. These factors include a broad range of inflammatory cytokines, chemokines, and signaling molecules that can influence the tumor microenvironment.

Studies suggest that senescence may significantly promote cancer metastasis. Therefore, this study aims to investigate the genes involved in cancer progression and to improve understanding of how SASP is regulated, which is critical for improving breast cancer outcomes. The central …

Effect Of Plant-Based Vs. Standard American Diet On Cardiovascular Parameters In College Students, Timothy J. Horanic

Honors Undergraduate Theses

This study examines how adherence to different dietary patterns—specifically a plant-based diet compared to the standard American diet—can influence physiological indicators tied to cardiovascular health, including heart rate variability (HRV), blood pressure (BP), and heart rate (HR). Among these markers, HRV is considered especially sensitive to autonomic nervous system (ANS) regulation and may offer earlier insight into physiological stress or dysfunction than HR or BP alone. Although nutritional habits are widely believed to impact heart health, few investigations have focused on how specific long-term diets affect autonomic and cardiovascular metrics in healthy, college-aged adults. This study aims to investigate if …

Non-Destructive Hhxrf Archaeometry For Grouping Individuals Via Trace Element Analysis Of Dental Remains, Griffon G. Binkowski

Graduate Studies Theses and Dissertations 2026

Handheld X-ray fluorescence (HHXRF) spectrometry has been validated as an accurate, non-destructive method for analyzing archaeological osseous materials. This study utilizes HHXRF to address key bioarchaeological questions, including population differentiation, individuation, and the interpretation of bioaccumulated trace elements versus diagenetic impacts. Using dental enamel from the Maya site of Altun Ha, Belize (n=20) and several Roman-Christian sites in the Dakhleh Oasis in Egypt (n=6), the occlusal surface of molar crowns was assayed in air using a Bruker Tracer III- equipped with a 12 mil Al, 1 mil Ti, 6 mil Cu filter. Semi-quantitative trace element ratios (Sr/Ca, Fe/Ca, and Zn/Ca) …

Exploring The Role Of Fatty Acid Signaling In Macrophages, Ayomide Ogunsanmi

Graduate Thesis and Dissertation post-2024

Dietary fatty acids play critical roles in both the gustatory and immune systems. In taste, they serve as the sapid molecules that underlie the ability to taste fat, whereas in the immune system, they serve as messengers that help facilitate the fuel-based reprogramming of macrophages (MΦ) that underlie optimal immune function. It has become clear in recent years that there is a functional interaction between the taste and immune system, and fatty acid signaling pathways serve as one focus of this overlap. Similar to taste receptor cells (TRCs), MΦ express G protein-coupled fatty acid receptors GPR120 and GPR84, and our …

Development Of Human Neuronal Microphysiological Models And Subsequent Integration Into Multi-Organ Platforms For Evaluation Of Therapeutic Efficacy And Off-Target Toxicity, Aakash Patel

Graduate Thesis and Dissertation post-2024

Microphysiological systems are a rapidly growing field of research for modeling of physiological processes and disease in an in vitro environment. The translatability and cost effectiveness of these platforms make them a valuable tool for drug discovery, allowing investigation of both efficacy and off-target toxicity either as a replacement or supplement to traditional animal models. Neurological disorders in particular are often difficult to emulate in an animal model, making the development of these models a highly useful area of research for both elucidation of brain function, as well as neurological disorders. Taking these models and integrating them into a multi-organ …

Ai-Infused Discussion Boards: Enhancing Engagement, Reflection, And Academic Integrity In Anatomy And Physiology Education, Wade Dauberman

Teaching Repository of AI-Infused Learning

This paper presents the design, implementation, and evaluation of an AI-infused discussion board assignment that promotes ethical AI engagement, enhances student learning in anatomy and physiology, and addresses academic integrity concerns in higher education.

Domain-Constrained Clustering: A Two-Stage Framework For Muscle Fiber Type Identification, Fanchao Yi

Graduate Thesis and Dissertation post-2024

This dissertation introduces a novel Two-Stage Clustering Framework for the automated identification of human skeletal muscle fiber types using fluorescence microscopy image intensity data. By integrating two complementary clustering methods, this framework overcomes the subjectivity and labor-intensive nature of traditional manual methods, offering an objective and efficient solution for large-scale muscle physiology research. The initial framework combined Density Peaks Clustering (DPC) with a Gaussian Mixture Model employing a t-distribution (GMM-t). This version was validated by comparing its clustering results with manual counts at the individual subject level. We successfully applied this framework in two published studies \cite{brennan2020,hinkley2023}, demonstrating its practical …

Fabricating Silver-Ceria Polymer Nanocomposite Scaffolds For Biomedical Therapeutic Applications, Shreya S. Pawar

Honors Undergraduate Theses

Improper healing of bone fractures and limited regeneration of bone following bone tumor resection remain a prevalent complication worldwide. Long-term effects of this include joint instability, limited movement, and arthritis. Bone infections (osteomyelitis), reactive oxygen species (ROS) generation via excessive inflammation, and underlying conditions such as osteoporosis can contribute to suboptimal bone tissue regeneration. ROS accumulation stimulates osteoblast apoptosis, while promoting osteoclast differentiation. These processes inhibit mineralization and osteogenesis. Conventional therapeutics involve the utilization of drugs and bone grafts. However, these approaches pose limitations and can result in subsequent complications. Microbial infections, ROS accumulation, and excessive inflammations are factors that …

Gait Kinematics And Muscular Responses To Rhythmic Perturbations In Healthy Young Adults, Kayley A. Romero

Graduate Thesis and Dissertation post-2024

Falls pose a significant risk across all ages, leading to injury and loss of independence. Understanding gait adaptation to external perturbations provides insights into balance control and muscle activation, with implications for rehabilitation and fall prevention. While entrainment, the synchronization of biological rhythms to external stimuli, has been widely studied using auditory and visual cues, its effects in response to mechanical perturbations remain unclear. This study examines how young, healthy adults adapt to discrete mediolateral perturbations and whether entrainment occurs when mediolateral perturbations are applied at set timings determined by their natural stride period.

Participants walked on a self-paced treadmill …

Deepfake Detection And Defense: An Analysis Of Techniques And Robustness, Nigel Francis

Graduate Thesis and Dissertation post-2024

The rise of deepfake media powered by the abrupt and rapid advances in generative AI, has introduced serious concerns and challenges in digital content verification. Although there is a wide range of detection strategies currently in use and being proposed, many remain limited in their ability to generalize across manipulation types, defend against adversarial attacks, or operate efficiently in real world scenarios. This paper presents a survey of deepfake detection and defense techniques, organized into ten technical categories: frequency-based, spatial-based, temporal-based, physiological-based, multimodal detection, adversarial attacks and defenses, forensic noise-based methods, watermarking and prevention strategies and dataset contributions. Drawing on …

Optimization Of L-Citrulline Production In Corynebacterium Glutamicum, And The Effect Of The Human Small Intestine Environment, Simran S. Ghulldu

Honors Undergraduate Theses

L-citrulline is a crucial amino acid involved in nitric oxide production, which supports cardiovascular health, physical performance, and intestinal well-being. Nitric oxide deficiency is linked to conditions like hypertension, highlighting the need for efficient L-citrulline production. This study attempts to enhance L-citrulline synthesis in Corynebacterium glutamicum, a bacterium widely used in industrial amino acid production, as well as test a The hypothesis is that overexpressing carAB, which encodes carbamoyl phosphate synthetase, will increase carbamoyl phosphate levels and boost L-citrulline production. Two C. glutamicum strains were used: a wild type and the CRBG strain, which has mutations that promote …

Understanding Health-Seeking Decision-Making Process And Behavior Among Haitian Immigrants: A Grounded Theory Approach, Shelleta Ladonice

Graduate Thesis and Dissertation 2023-2024

Black people in the U.S. die at younger ages, have significantly higher rates of death from treatable medical conditions, are more likely to have late-stage breast and colon cancer diagnoses and more likely to die from these cancers, and are at higher risk for chronic illnesses compared to other racial and ethnic groups. Accessing healthcare is crucial to health and well-being; however, U.S. immigrants' use of healthcare services is far less than native-born Americans. Haitian immigrants experience health disparities at the highest rate compared to other Black immigrants in the U.S. Given their unique history, culture, and immigration experience, it …

A Cfd Framework To Study Complex Effects Relating To Airborne Viral-Pathogen Transmission, Rajendra Shrestha Mr.

Graduate Thesis and Dissertation 2023-2024

This research used computational fluid dynamics (CFD) to examine the behavior of airborne droplets released during respiratory events. The CFD model utilizes an Eulerian-Lagrangian approach, with turbulence resolved using the Spalart-Allmaras detached eddy simulation. The first part investigates airborne transmission and how modifying saliva during a sneeze impacts this process. The study employs CFD to simulate these respiratory events in a ventilated room. It finds that larger droplets alone are insufficient for droplet settling due to secondary breakdown processes. Modifiers that increase the Ohnesorge number show resistance to aerosolization from secondary breakup, resulting in more droplets with high settling rates, …

Gait Entrainment & Energetics Of Young Adults To Discrete Mediolateral Perturbations, Lindsey D. Lee

Graduate Thesis and Dissertation post-2024

Entrainment is a natural phenomenon that occurs with synchronization to a rhythmic stimulus which can be auditory, visual, or mechanical. An everyday example is walking next to someone and synchronizing your steps. Previous studies have explored entrainment from auditory cues, such as a metronome, and mechanical cues, such as an exoskeleton applying a force at the ankle. These studies have found entrainment is more likely to occur if the stimulation frequency is close to the person’s natural locomotion frequency. Previously we found when discrete mediolateral perturbations were applied on a treadmill, participants increased their speed and retained this increased speed …

Dysbiosis In Parkinson's Disease: A Meta-Analysis Of Gut Microbiota And Its Role In Gastrointestinal Dysfunction And Disease Progression, Ayan M. Siddiqui Mr.

Honors Undergraduate Theses

Parkinson's Disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor symptoms, including gastrointestinal (GI) dysfunction. Symptoms such as constipation, bloating, and nausea often show early signs before the onset of motor symptoms. Recent research has suggested an essential role of the human gut microbiome and gut dysbiosis, an imbalance in gut microbiota composition, in the pathogenesis of PD. This thesis aims to assess the potential relationship between gut dysbiosis and PD by conducting a meta-analysis, focusing on differences in gut microbiota between PD patients and healthy controls and evaluating their implications for GI dysfunction and PD progression. The …

Development Of A Novel Mitochondria Biosensor, Randall K. James

Graduate Thesis and Dissertation post-2024

Developing new label-free paradigms for functional assays in biomedical research has the potential to catalyze efforts in drug discovery and improve the understanding of complex disorders. Mitochondria are an essential organelle in nearly every eukaryotic organism that perform vital functions such as ATP production, redox signaling, reactive oxygen species (ROS) homeostasis and regulation of programmed cell death. These activities are regulated by electrophysiological processes that occur in the inner mitochondrial membrane (IMM) and outer mitochondrial membrane (OMM) in response to metabolic demands, making them an important physiological marker for bioenergetic studies. Mitochondria dysfunction is an early pathological biomarker of complex …

Role Of Vitamin D, Folate, And Cobalamin Deficiency In Mycobacterium Avium Paratuberculosis Infection And Inflammation, Joseph Vaccaro

Electronic Theses and Dissertations, 2020-2023

Vitamin D, folate, and cobalamin (vitamin B12) are crucial micronutrients in human physiology that are necessary for healthy calcium, phosphorus, and single-carbon metabolism. Recent studies have indicated that these vitamins also affect the inflammatory response in ways unrelated to their well-characterized deficiencies. Accordingly, analysis of their effect on chronic inflammatory diseases like Crohn's disease (CD) is warranted. This investigation examines the effects of vitamin deficiency on macrophages and intestinal epithelial cells upon exposure to Mycobacterium avium paratuberculosis (MAP,) a pathogen capable of triggering CD, to model the inflammatory response in clinical CD patients. ELISA analysis of CD patient plasma established …

The Cost, Politics And Controversy Of Human Space Flight In Nigeria Or How To Put The First African Astronaut Into Space, Desiree Winns

Honors Undergraduate Theses

The most pressing barriers between reality and the dream of the first African astronaut in space are a lack of resources, cooperation, and support. However, Nigeria presently suffers from the threat of famine, intercommunal violence, and population displacement as a result of terrorism and food insecurity. The reliance upon humanitarian aid from countries such as the United States and international NGOs creates a question of whether Nigeria should even be considering exploration of space. It can be said that any investment into space should instead be granted to displaced people, water and food security, and cracking down on terrorism. Why …

Bacterial Association Networks From Healthy And Cancer-Associated Gut Microbiomes, Mark Loftus

Electronic Theses and Dissertations, 2020-2023

The human gastrointestinal tract is colonized by a diverse community of symbiotic microorganisms, mainly bacteria, that are known to play essential roles in maintaining the health of their human host. Disruption of this bacterial community has been associated with numerous diseases, including Colorectal Cancer (CRC). CRC is one of the leading causes of cancer-related deaths worldwide. As such, focus has been placed on the modulation of the bacterial community within the cancer-associated gut microbiome as the next step in possible CRC treatment and prevention strategies. To use the bacterial community for these purposes, a better understanding of the associations that …

Identifying The Links Between Mental Frameworks, Context Features, And Driver Attention In Complete Streets Environments, Patricia Tice

Electronic Theses and Dissertations, 2020-2023

Complete street systems integrate a wide range of users in the same space, with unequal risks and responsibilities. This makes driver attention a critical factor in assuring the safety of vulnerable users. The Conditioned Anticipation of People psychological model of driver attention proposes that drivers reflexively reengage their metacognitive processes when they anticipate visually interacting with the human face or form due to the neurological priority that the brain places on human recognition. To test this model, an eye-tracking tabulation was generated from the SHRP2 Naturalistic Driving Study that measured midsegment percent of time on-task and multitasking behavior for 200 …

Rethinking Sleep Quality In Fotels: Examining The Risk And Protective Factors Associated With Travel-Related Insomnia, Wei Xiong, Meijiao Huang, Bendegul Okumus, Fang Fan

Faculty Scholarship and Creative Works

This study attempts to illustrate how traveling affects the sleep and well-being of hotel guests. We collected data from hotel guests and looked at various factors affecting their sleep quality during travel. The particular impact of said variables on insomnia was analyzed using a binary logistic regression. Study results show that the risk factors of developing insomnia while traveling include unhealthy sleep habits at ordinary times, being an early riser, short sleep durations, business trips, and sensitivity to unfamiliar environments. Protective factors include being a late sleeper and being satisfied with the accommodation facilities. The research findings offer specific theoretical …

Comparative Examination Of The Empatica E4 To Record Heart Rate Variability Metrics, Andres Rosero

Honors Undergraduate Theses

The increased accessibility of cyber technology has resulted in advancements in international communications and information sharing never seen in human history. With this new age of digital software comes the proliferation of illegal online activity and cyber terrorism. Repercussions of cyber-attacks have ranged from identity theft to leaks of classified state secrets. To combat this threat, the Department of Defense (DoD) established the Cyber Mission Force (CMF) to head operations in the interests of protecting against cyber-attacks. One of the CMF’s initial projects involves the creation of a Performance Assessment Suite (PAS), a training program designed to improve the training …

The Effects Of Sleep Deprivation On Mental Health And Neurological Disorders, Gabriella Victoria Fernandez De Salvo

Honors Undergraduate Theses

Sleep deprivation is defined as an individual sleeping less than 6 hours per night. It is a common behavior amongst individuals who live in industrialized nations.Along with industrialization, its prevalence is also expected to rise with age. Despite this, there has been a shift in recent years with sleep deprivation increasing in the youth, likely related to the increased use of technology during the nighttime. Sleep deprivation and chronic sleep disruption are behaviors commonly observed amongst patients suffering from neurological and psychiatric disorders, like Alzheimer’s disease, Parkinson’s disease, depression, and anxiety. Many of these patients suffer from sleep disorders like …

Non-Linear Inverse Liquid-Solid Chromatography As A Methodology To Characterize Drug Concentration Losses To Polymeric Materials Used In Body-On-A-Chip Devices For Drug Discovery, Mark Schnepper

Electronic Theses and Dissertations, 2020-2023

Body-on-a-chip and human-on-a-chip systems are currently being used to augment and could eventually replace animal models in drug discovery and basic biological research. However, hydrophobic molecules, especially therapeutic compounds, tend to adsorb to the polymer materials used to create these microfluidic platforms, which may distort the dose-response curves that feed into Pharmacokinetic/Pharmacodynamic (PK/PD) models which translate preclinical data into predictions of clinical outcomes. Adsorption of hydrophobic molecules to these polymer materials needs better characterization. Inverse Liquid-Solid Chromatography paired with a numerical optimization based on the Langmuir model of adsorption was used to characterize the adsorption isotherm parameters of selected drugs …

Development Of A Functional Testing Platform For The Sensory Segment Of The Neuromuscular Reflex Arc, Alisha Colon

Electronic Theses and Dissertations

Investigations of human biology and disease have been hindered by the use of animal models. The information obtained from such studies often results in clinically irrelevant results and drug trial failures. Additionally, several governing bodies have been formulating legislation to move away from animal models and toward more ethical and efficient testing platforms for drug discovery and cosmetic research. As an answer to these issues, "body-on-a-chip" systems have been a rapidly developing field which easily recapitulates in vivo functionality, providing a more relevant, repeatable, and ethical testing platform to better predict biology. These systems can be used as human-based testing …

If A Virtual Tree Falls In A Simulated Forest, Is The Sound Restorative? An Examination Of The Role Of Level Of Immersion In The Restorative Capacity Of Virtual Nature Environments, Jessica Michaelis

Electronic Theses and Dissertations

Stress and cognitive fatigue have become a pervasive problem, especially in Western society. Stress and cognitive fatigue can have deleterious effects not only on performance, but also on one's physical and mental health. This dissertation presents a study in which the aim is to investigate the effects of virtual nature on stress reduction and cognitive restoration. Specifically, this study assessed the effects of Immersion (Non-immersive, Semi-immersive, Fully-immersive) and Exploration (Passive vs Active) on stress reduction and cognitive restoration. Additionally, restoration from the most effective virtual nature environment was compared to that of taking an active coloring break. Eighty-three university students …

Learning Opportunities And Challenges Of Sensor-Enabled Intelligent Tutoring Systems On Mobile Platforms: Benchmarking The Reliability Of Mobile Sensors To Track Human Physiological Signals And Behaviors To Enhance Tablet-Based Intelligent Tutoring Systems, Luis Vazquez

Electronic Theses and Dissertations

Desktop-based intelligent tutoring systems have existed for many decades, but the advancement of mobile computing technologies has sparked interest in developing mobile intelligent tutoring systems (mITS). Personalized mITS are applicable to not only stand-alone and client-server systems but also cloud systems possibly leveraging big data. Device-based sensors enable even greater personalization through capture of physiological signals during periods of student study. However, personalizing mITS to individual students faces challenges. The Achilles heel of personalization is the feasibility and reliability of these sensors to accurately capture physiological signals and behavior measures. This research reviews feasibility and benchmarks reliability of basic mobile …

Simultaneous Use Of Physiological Sensors For A Neuromarketing Task, Charles Descheneaux

Electronic Theses and Dissertations

Physiological measurements have become more popular in Psychological research over the past ten years. These advancements allowed different objective sensors to become another measurement tool in a scientific arsenal of collecting data. Traditionally, performance and after task subjective measures have been used for most studies in Psychological research. With the opportunity to use these subjective measures along with objective measures, more data can be collected during research and therefore potentially produce better quality conclusions. Eye Tracking (ET), functional near infrared (fNIR), transcranial Doppler ultrasound (TCD), electrocardiogram (EKG) and the electroencephalogram (EEG) have shown great promise in their ability to produce …

Development And Validation Of A Scale To Measure Misconceptions About Educational Psychology Among Pre-Service Teachers, Morgan Mcafee

Electronic Theses and Dissertations

Misconceptions are widespread or commonly held beliefs explicitly contradicted by empirical evidence. When teachers harbor misconceptions or unjustified beliefs about teaching, learning, and human motivation, the potential pedagogical consequences are profound, and these inaccurate beliefs may be instilled into future students through ineffective teaching strategies and gross misinterpretations of learning science. While existing research has examined misconceptions about general psychology and neuroscience among various populations, no prior work has evaluated pre-service teachers' misconceptions about topics of educational psychology, comprising inaccurate beliefs about teaching, learning, and human motivation. The purpose of this research is to describe the development and validation of …