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Non-Destructive Hhxrf Archaeometry For Grouping Individuals Via Trace Element Analysis Of Dental Remains, Griffon G. Binkowski
Non-Destructive Hhxrf Archaeometry For Grouping Individuals Via Trace Element Analysis Of Dental Remains, Griffon G. Binkowski
Graduate Studies Theses and Dissertations 2026
Handheld X-ray fluorescence (HHXRF) spectrometry has been validated as an accurate, non-destructive method for analyzing archaeological osseous materials. This study utilizes HHXRF to address key bioarchaeological questions, including population differentiation, individuation, and the interpretation of bioaccumulated trace elements versus diagenetic impacts. Using dental enamel from the Maya site of Altun Ha, Belize (n=20) and several Roman-Christian sites in the Dakhleh Oasis in Egypt (n=6), the occlusal surface of molar crowns was assayed in air using a Bruker Tracer III- equipped with a 12 mil Al, 1 mil Ti, 6 mil Cu filter. Semi-quantitative trace element ratios (Sr/Ca, Fe/Ca, and Zn/Ca) …
Genuine And Meaningful Black Character Narratives In Video Games, Derek L. Manns
Genuine And Meaningful Black Character Narratives In Video Games, Derek L. Manns
Graduate Studies Theses and Dissertations 2026
The lack of Black representation in video games reflects stereotypes and hollow narratives. Authentic and meaningful design of Black characters allows Black players a reflection of emotional attachments everyone wants when playing a game. Examining racial identities through avatars, critiquing the notion that customization equates to racial inclusivity, limited options and predominant, white-coded protagonists reinforce systemic biases in games (Dietrich, 2013). My Afrofuturistic content analysis framework explores Black culture with a future of speculative fiction. Reimagining the past, present, and future through Black narratives for alternate futures (Womack). Integrating these ideas enhance culture and aesthetics in this dissertation to highlight …
Experimental And Numerical Study On The Stability Limits Of Ammonia And Ammonia/Hydrogen Flames Inside A Toroidal Jet-Stirred Reactor, Guillermo Alberto Barrios Cadenas
Experimental And Numerical Study On The Stability Limits Of Ammonia And Ammonia/Hydrogen Flames Inside A Toroidal Jet-Stirred Reactor, Guillermo Alberto Barrios Cadenas
Graduate Studies Theses and Dissertations 2026
Ammonia’s (NH3) properties as a carbon-free hydrogen carrier, its phase characteristics, and its wide global infrastructure present a solid case as a potential surrogate for carbon-based aviation fuels. Delivering a zero-emission NH3-based engine requires careful integration and optimization of the combustor and thermal management systems, a process that requires high-fidelity chemical reacting models experimentally validated through the use of simplified combustors. This study investigates NH3 fundamental combustion characteristics at conditions relevant to aviation gas turbines using a newly constructed toroidal jet-stirred reactor (TJSR) facility. Lean blow-off (LBO) experiments were carried out for NH3 blends …
From Motherhood To Sisterhood: Women Strike For Peace And The Transmission Of Feminist Consciousness, Olivia R. Aldrich
From Motherhood To Sisterhood: Women Strike For Peace And The Transmission Of Feminist Consciousness, Olivia R. Aldrich
Graduate Studies Theses and Dissertations 2026
Women Strike for Peace (WSP) has traditionally been understood as a maternalist peace movement that emerged in response to atmospheric nuclear testing during the early Cold War era. This thesis argues that WSP’s history reveals a more nuanced relationship between motherhood, feminism, and political activism than existing scholarship has suggested. Rather than operating in distinct stages, maternalism and feminism operated simultaneously, working alongside one another throughout the organization’s history. Furthermore, this thesis builds upon Ednie Kaeh Garrison’s concept of feminist “radio waves,” arguing that WSP functioned as a transmitter of feminist consciousness, where ideas, organizational practices, and different political identities …
Participatory Barriers And Single-Member Districts In Planning For Latino Demographics: A Spatial Analysis Of Osceola County, Florida, Amy Garcia Paniagua
Participatory Barriers And Single-Member Districts In Planning For Latino Demographics: A Spatial Analysis Of Osceola County, Florida, Amy Garcia Paniagua
Honors Undergraduate Theses
This mixed-methods case study on Osceola County, Florida examines how participatory barriers shape planning outcomes for Latino communities within single member district systems. Demographic transformation has shaped Osceola into one of three Hispanic/Latino majority counties. For Latinos, unique barriers to civic access exist, with the potential for exclusion in planning processes. The research bridges participatory planning theory with theories supporting single-member district electoral representation by evaluating whether district-level governance mitigates inequities where civic engagement is constrained. Methods integrate GIS-based spatial analysis with an institutional review of district-level actions to assess relationships between Hispanic civic accessibility and planning equity. Two composite …
Survey Measures On Perinatal Cannabis Use, Aaditya Balasubramaniyan, Jacquelyn Reiss, Amy Donley
Survey Measures On Perinatal Cannabis Use, Aaditya Balasubramaniyan, Jacquelyn Reiss, Amy Donley
Institute for Social and Behavioral Science (ISBS)
No abstract provided.
The Effects Of Stress-Related Hormones On Excitatory Synapse Formation, Autumn C. Garvey
The Effects Of Stress-Related Hormones On Excitatory Synapse Formation, Autumn C. Garvey
Honors Undergraduate Theses
Stress profoundly influences brain function through neuromodulatory hormones that regulate synaptic plasticity, yet how temporal patterns of hormone exposure shape excitatory synapse formation remains poorly understood. This study investigates how exposure to stress hormones, norepinephrine and cortisol, affects excitatory synapse development. While existing research primarily compares concentration models, real-world stress occurs in variable patterns that may produce distinct neural outcomes. To address this gap, differentiated Neuro2A neuronal cells are exposed to norepinephrine or cortisol under a continuous treatment paradigm designed to model chronic stress conditions. Following treatment, immunofluorescence imaging is utilized to quantify excitatory synapse formation through analysis of presynaptic …
Comparative Analysis Of Serum-Free Culture Conditions On Cell Proliferation And Extracellular Vesicle Production By Adipose-Derived Stem Cells, Ayna Ghulldu
Honors Undergraduate Theses
Adipose-derived stem cells (ADSCs) are promising candidates in regenerative medicine due to their proliferative capacity, self-renewal, and secretion of extracellular vesicles (EVs) that mediate intercellular communication. Serum-free media has been increasingly explored for MSC culture as it eliminates xenogeneic components, improving human therapeutic suitability. However, comparative evaluation of distinct serum-free formulations on ADSC proliferation and EV output simultaneously remains limited. This study compares a serum-containing medium to three proprietary serum-free media prototypes differing in composition, including the presence or absence of extracellular matrix proteins, to inform the optimization of culture conditions for clinical use. Proliferation, EV characteristics, and gene expression …
The Depuration Of Microplastic Pollution In Aquacultured Indian River Lagoon Oysters, Lee Nguyen
The Depuration Of Microplastic Pollution In Aquacultured Indian River Lagoon Oysters, Lee Nguyen
Honors Undergraduate Theses
Plastics are widely used in consumer goods and industrial manufacturing, and their degradation into microplastics (MP, size < 5 mm) has created an emergent environmental pollutant. Plastics readily enter aquatic environments, where they accumulate additional contaminants and bioaccumulate in organisms. While MP contamination in marine ecosystems is well documented, less is known about MP presence in aquacultured shellfish. Depuration, the process of purging contaminants from shellfish, is conducted in sterile seawater without food, which may cause oyster starvation and death. To date, MP depuration has not been examined in the aquacultured eastern oyster (Crassostrea virginica) in published studies. This study had 3 goals: 1) evaluate the effects of algal feed on oyster survival during depuration, 2) determine the effect of algal feed on depuration effectiveness, and 3) investigate the effect of a ten-day depuration on MP concentration in aquacultured C. virginica soft tissue. MP were quantified in oyster tissues, biodeposits, and in industrial algal feed. Tissues were digested using alkaline solutions, manually examined via microscopy, and analyzed using Fourier-Transform Infrared Spectroscopy (FTIR) to investigate MP polymer …
The Impact Of Gastric Sleeve And Roux-En-Y Gastric Bypass On Chief Cell Function And Protein Digestion In Obese Patients, Garikoitz Mikel Gainza
The Impact Of Gastric Sleeve And Roux-En-Y Gastric Bypass On Chief Cell Function And Protein Digestion In Obese Patients, Garikoitz Mikel Gainza
Honors Undergraduate Theses
Obesity has become one of the largest global health concerns of the 21st century, correlating with numerous associated diseases. To help address the growing prevalence and burden of obesity, sleeve gastrectomy and Roux-en-Y gastric bypass have become two commonly performed surgical procedures done to promote weight loss by altering the anatomical structure of the stomach and surrounding organs of the gastrointestinal system. Although the benefits of improved metabolism linked to these surgical procedures are well studied, their impact on the physiology of gastric cells, and more specifically chief cells as they relate to protein digestion post-surgery, is yet to …
Examining The Results Of Revolutions In The Third World: A Case Study Of The Iranian, Libyan, And Nicaraguan Revolutions, Noah A. Mohammedelamien
Examining The Results Of Revolutions In The Third World: A Case Study Of The Iranian, Libyan, And Nicaraguan Revolutions, Noah A. Mohammedelamien
Honors Undergraduate Theses
This thesis examines the post-revolutionary trajectories of Libya, Iran, and Nicaragua to explain why some Third World revolutionary projects preserve and use elements of their founding ideology while others fragment, personalize, or diffuse over time. Rather than focusing on the causes of revolution alone, it analyzes the durability of religious-socialist ideological continuity after revolutionary upheaval. Using a (MDSD) comparative historical and institutional approach grounded in primary and secondary sources, the study evaluates five key dimensions across the cases: religious-socialist ideological fusion, religious elite loyalty, popular religious mobilization, institutional embedding of ideology, and external pressure. The findings suggest ideological continuity is …
Associations Between Oral Hormonal Contraceptive Use, Digestive And Other Health Symptoms In Young Women, Silviana E. Buzatu
Associations Between Oral Hormonal Contraceptive Use, Digestive And Other Health Symptoms In Young Women, Silviana E. Buzatu
Honors Undergraduate Theses
Oral hormonal contraceptives (OHCs) are widely used among reproductive-age women; however, their gastrointestinal (GI) side effects remain understudied. The present study examined associations between OHC use, GI, physical, and psychological symptom burden in a large sample of undergraduate women. Participants (N = 669) aged 18 to 25 years were recruited from UCF’s SONA system and classified into three groups based on self-reported contraceptive status: no birth control, combined estrogen–progestin OHC, and progestin-only OHC. Participants completed GI questionnaires, as well as physical and mental health symptoms ones.
Multivariate analyses indicated that overall GI symptom profiles did not differ significantly by birth …
Repurposing Cyclin-Dependent Kinase Inhibitors For The Discovery Of Novel Antiplasmodial Compounds, Ritam Bhowmik
Repurposing Cyclin-Dependent Kinase Inhibitors For The Discovery Of Novel Antiplasmodial Compounds, Ritam Bhowmik
Honors Undergraduate Theses
Malaria remains a major global health burden with over 282 million cases annually and rising resistance to artemisinin-based combination therapies. Plasmodium falciparum, the most lethal malaria parasite species in humans, relies on tightly regulated cell cycle progression during replication within red blood cells. Cyclin-dependent kinases (CDKs) are central regulators of eukaryotic cell division and transcription, and several CDK-like enzymes in P. falciparum, including Pfmrk and PfPK6, are essential for parasite growth and structurally distinct from human kinases. This study evaluated whether commercially available human CDK inhibitors (CDKIs) targeting cancer pathways could be repurposed as novel antimalarial compounds. A library of …
Self-Reported Psychological Effects Of Rock Climbing In Adults On The Autism Spectrum, Brennan Gleason
Self-Reported Psychological Effects Of Rock Climbing In Adults On The Autism Spectrum, Brennan Gleason
Honors Undergraduate Theses
Background: Prior research has shown rock climbing to have considerable therapeutic potential through such mechanisms as boosting self-esteem, promoting mindfulness, and creating a supportive social community. (Liu et al., 2022, Osborne et al., 2025). Meanwhile, autistic adults experience mood disorders at a significantly higher rate than the general population; upwards of 54% are diagnosed with a psychiatric condition (Croen et al., 2015). Many of the issues negatively affecting autistic adults align with the benefits of rock climbing, including low self-esteem, inadequate social support, and anxiety.
Objective: This study aimed to find differences in mental health outcomes between autistic adults who …
Health Care Governance And Structural Exclusion In Florida: A Human Rights Analysis Of Access For Latinx Communities, Natalie Medrano
Health Care Governance And Structural Exclusion In Florida: A Human Rights Analysis Of Access For Latinx Communities, Natalie Medrano
Honors Undergraduate Theses
Access to health care in the United States is a complex system shaped by statutory programs and the discretionary powers of state governance. This thesis examines how Florida’s healthcare system structures access through administrative design, with particular attention to its impact on Latinx communities. Although formally race-neutral, Florida’s reliance on Medicaid non-expansion, managed care delivery, and complex eligibility processes produces systemic barriers that limit access for low-income populations. Drawing on the international right-to-health framework articulated in General Comment No. 14 of the International Covenant on Economic, Social and Cultural Rights, alongside Latinx Critical Race Theory (LatCrit), this study analyzes how …
Manuka Honey Modulates Oxidative Stress In Neuro2-A Cells Through Mitochondrial Regulation, Rachel Abramovici
Manuka Honey Modulates Oxidative Stress In Neuro2-A Cells Through Mitochondrial Regulation, Rachel Abramovici
Honors Undergraduate Theses
Manuka honey is known for its vital usage in wound healing, being an agonist towards fighting infections, and is an acting antioxidant [32]. Its main constituents are flavonoids and phenolic compounds, with methyl syringate (MSYR) being a major active ingredient. The specific compounds responsible for these antioxidant effects, particularly in the CNS, remain unclear. It is hypothesized that pre-treatment of mouse neuroblastoma cells with MSYR followed by hydrogen peroxide exposure will activate the AMPK/SIRT1/PGC-1a pathway, due to MSYR’s phenolic structure, and thus reduce oxidative stress and improve mitochondrial biogenesis. Hydrogen peroxide is a standard reactive oxygen species (ROS) treatment to …
Transforming Florida Chemistry Education: Exploring Information Literacy Strategies From Singapore, Han N. Le
Transforming Florida Chemistry Education: Exploring Information Literacy Strategies From Singapore, Han N. Le
Honors Undergraduate Theses
This study explores the applicability of Singapore’s information literacy (IL) strategies within Central Floridian higher education environments. Singapore’s national IL framework, supported by its Ministry of Education, integrates information and communication technology (ICT), professional development, and lifelong learning initiatives through a standardized, systemwide approach. In contrast, IL instruction in the United States is largely decentralized, often limited to one-time sessions or elective courses. To investigate the feasibility of adapting Singapore’s practices, surveys were distributed to faculty and librarians across Florida’s twelve public universities, yielding responses that highlighted varying levels of IL integration, limited institutional support, and minimal professional training related …
A Systematic Literature Review Of The Possible Negative Impacts Of Overconsumption Of Mass Media And Technology On Elementary-Aged Members Of Generation Z (1997–2012) And Generation Alpha (2013–2024), Ashya Y. Warren
Honors Undergraduate Theses
This thesis explores the possible negative impacts of overconsumption of mass media and technology on the elementary-aged members of Generation Z (1997-2012) and Generation Alpha (2013-2024). This research is aimed at establishing the relationship between excessive and uncontrolled exposure to digital media and cognitive, emotional, social, behavioral, and academic difficulties at a critical period of child growth. The purpose of this systematic literature review can be explained by the author's experience with technology overuse and professional interests as a future teacher, who should be prepared to help promote healthy childhood and development. The systematic literature review was based on peer-reviewed …
Impact Of Lifestyle Factors On Allergic Rhinitis Symptoms And Quality Of Life Among College Students, Lina Saint-Hilaire
Impact Of Lifestyle Factors On Allergic Rhinitis Symptoms And Quality Of Life Among College Students, Lina Saint-Hilaire
Honors Undergraduate Theses
This study aims to examine the influence of certain lifestyle factors on the presentation of allergic rhinitis symptoms and the quality of life of college students. Factors of interest include residential setting, household cleaning habits, age of symptom onset, and exposure to household pets. Additional analysis includes assessment of the impact of allergic rhinitis symptoms on sleep. Using a cross-sectional survey design, student responses were self-reported through a paper survey distributed during tabling days at the University of Central Florida (UCF) main campus. Eligible participants had to be 18 years or older and current UCF graduate and undergraduate students. Survey …
Multicomponent Deoxyribozyme Probes For Targeted Detection Of Cancer Associated Gene Insertions, Samuel R. Veleke
Multicomponent Deoxyribozyme Probes For Targeted Detection Of Cancer Associated Gene Insertions, Samuel R. Veleke
Honors Undergraduate Theses
Insertions and deletions (indels) in DNA sequences of genes are linked with cancers such as glioblastoma (GB). Thus, indels may be used as potential cancer biomarkers. In the NANOG gene, its pseudogene NANOGP8 has a 22 base pair insertion sequence for GB patients. In this work, the NANOG gene and the insertion sequence were detected in one sample using a dual-fluorescent assay containing two multicomponent split deoxyribozyme (Dz) probe complexes. One complex used TXR fluorescence to detect the gene regardless of the insertion’s presence. The other complex used fluorescein (FAM) fluorophore to detect the insertion. The probes were able to …
Evaluating The Effectiveness Of Nurse-Led Prenatal Education On Maternal Outcomes And Labor Satisfaction, Alexis Boris
Evaluating The Effectiveness Of Nurse-Led Prenatal Education On Maternal Outcomes And Labor Satisfaction, Alexis Boris
Honors Undergraduate Theses
Prenatal education has been a long-time major component of maternal healthcare, which has been known to impact expectant mothers and their level of preparedness during the labor and birthing process. Nurses have historically been key educators in the maternity field, due to their accessibility, education, and holistic approach in the healthcare system. Despite their recognition as vital educators in this field and the importance of maternal prenatal education, maternal healthcare is still affected by many modern-day factors, such as access to healthcare and education, health disparities, and negative childbirth experiences. This integrative literature review aims to evaluate the overall effectiveness …
Bodies Of Knowledge: The Accuracy Of Medical Anatomical Drawings From The 14th To The 18th Century, Marina G. Mitchell
Bodies Of Knowledge: The Accuracy Of Medical Anatomical Drawings From The 14th To The 18th Century, Marina G. Mitchell
Honors Undergraduate Theses
From the fourteenth to the eighteenth centuries, European anatomical illustration underwent major transformations in response to changing scientific methods, technologies, and visual conventions, reflecting critical transitions in anatomical history. Scientific evolution allowed these images to achieve increasing structural precision and internal detail, though they frequently diverged from anatomical forms as they are understood today. This study examines how anatomical inaccuracies across five centuries emerged not from ignorance, but from deliberate mediation between purpose, observation, pedagogy, artistic convention, and cultural ideology. Through close analysis of works in visual comparison to their modern counterparts, this thesis identifies specific deviations from the twenty-first …
Gen Z Perspectives On Mental Health Service Interaction: A Qualitative Content Analysis Of Reddit Discourse, Victor A. Aguiar
Gen Z Perspectives On Mental Health Service Interaction: A Qualitative Content Analysis Of Reddit Discourse, Victor A. Aguiar
Honors Undergraduate Theses
Compared to prior generations, Generation Z engages with mental health and mental health service interaction in distinct ways, frequently using social media platforms to share experiences, concerns, and opinions. Previous research has examined mental health discourse on Reddit; however, much of this work relies on inductive thematic approaches and offers limited focus on mental health service interaction and the factors influencing utilization. Guided by the Theory of Planned Behavior (TPB), this study examines how Generation Z discusses mental health service use through online discourse. Public Reddit posts authored by users identifiable as Generation Z, based on self-reported age, school enrollment, …
Social Determinants Of Health Affecting Cardiovascular Health Among South Asian Americans, Ann Mary Thomas
Social Determinants Of Health Affecting Cardiovascular Health Among South Asian Americans, Ann Mary Thomas
Honors Undergraduate Theses
Background: South Asian Americans experience disproportionately high rates of cardiovascular disease, yet the social determinants contributing to these disparities remain understudied.
Objective: This systematic review examines the role of social determinants of health (SDOH) in shaping cardiovascular outcomes among South Asian Americans.
Methods: A systematic literature search was conducted across PubMed, MEDLINE, and Web of Science using predefined search terms related to South Asian populations, cardiovascular health, and SDOH. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 reporting guidelines, and study screening and management were performed using Covidence. A total …
Distribution And Morphology Of Catecholaminergic Axons And Terminals In Flat-Mounts Of The Whole Left Ventricles Of Rats: Tracing, Digitization And 3d Scaffold, Emily Liu
Honors Undergraduate Theses
Cardiac sympathetic innervation plays a vital role in regulating various heart functions, and its remodeling has been linked to a range of cardiovascular diseases. To understand cardiac sympathetic innervation and remodeling, it is important to elucidate the topographical distribution and morphology of sympathetic axons in the whole left ventricle. However, immunohistochemistry (IHC) on whole heart tissues presents challenges due to their thickness, as conventional methods label only small sections. This disrupts tissue integrity and neural connections. To overcome this, we developed a whole flat-mount technique to process the rat heart (ventricle thickness: 3 mm). We performed cardiac sympathetic nerve imaging …
Socioeconomic Stressors And Their Association With Anxiety And Depression In Undergraduate And Graduate Students, Shreyaashri Selvakumar
Socioeconomic Stressors And Their Association With Anxiety And Depression In Undergraduate And Graduate Students, Shreyaashri Selvakumar
Honors Undergraduate Theses
Socioeconomic status (SES) is a social determinant of mental health that may influence the prevalence of anxiety and depression in undergraduate and graduate students. Students from lower socioeconomic backgrounds often encounter financial, academic, and social stressors, which may contribute to poorer mental health outcomes. This study investigates the association between SES-related factors and symptoms of anxiety and depression in undergraduate and graduate students. Data were collected from a large national survey of students in various degree programs and included measures of financial circumstances, food and housing insecurity, access to mental health services, and other demographic variables. Symptoms of depression and …
Perceptions Of Illicit Drug Use And Perceived Drug Misuse Risks Among Individuals With Military Experience, Emilia Havlicek
Perceptions Of Illicit Drug Use And Perceived Drug Misuse Risks Among Individuals With Military Experience, Emilia Havlicek
Honors Undergraduate Theses
This study investigates perceptions of illicit drug use and perceived drug misuse risks among individuals with military experience in the United States, highlighting how military service shapes attitudes toward substance misuse. Using data from the National Survey on Drug Use and Health (NSDUH), this research examines the influence of military status, combat exposure, PTSD, gender, and sociodemographic factors on perceptions of drug-related risk. Findings indicate that while most individuals perceive illicit drug use as highly risky, important differences exist among subpopulations, particularly female veterans, who are more likely to perceive lower levels of risk. The study explores how military culture, …
Impact Of Senescence On Breast Cancer Outcomes, Gracie Sous
Impact Of Senescence On Breast Cancer Outcomes, Gracie Sous
Honors Undergraduate Theses
Cellular senescence is a biological process in which damaged cells exit the cell cycle while remaining metabolically active and accumulating within tissues. Senescence plays a complex role in breast cancer progression, largely through the secretion of senescence-associated secretory phenotype (SASP) factors. These factors include a broad range of inflammatory cytokines, chemokines, and signaling molecules that can influence the tumor microenvironment.
Studies suggest that senescence may significantly promote cancer metastasis. Therefore, this study aims to investigate the genes involved in cancer progression and to improve understanding of how SASP is regulated, which is critical for improving breast cancer outcomes. The central …
Feasibility Of Telehealth-Delivered Gut-Directed Hypnotherapy For Managing Gastrointestinal Health: Exploring Specific Vs. Nonspecific Effects, Sabrina Romero
Feasibility Of Telehealth-Delivered Gut-Directed Hypnotherapy For Managing Gastrointestinal Health: Exploring Specific Vs. Nonspecific Effects, Sabrina Romero
Honors Undergraduate Theses
This randomized controlled trial evaluated the feasibility and efficacy of telehealth-delivered Gut-Directed Hypnotherapy (GDH) compared to General Hypnotherapy (GH) for managing gastrointestinal symptoms associated with disorders of gut–brain interaction (DGBI). Eleven adults were randomized to receive four 1-hour hypnotherapy sessions over a 14-day period via Zoom (GH n = 5; GDH n = 6). Primary outcomes included PROMIS GI Belly Pain T-scores and Abdominal Pain Ratings assessed at baseline and post-treatment. Follow-up assessments were conducted at three months (n = 8). At post-treatment, participants receiving GDH demonstrated significantly lower PROMIS GI Belly Pain T-scores compared to GH, F(1, …
Investigating The Interaction Of Gram-Positive Lactobacillus Species With Mucin In The Context Of Barrett's Esophagus, Ritisha Suresh
Investigating The Interaction Of Gram-Positive Lactobacillus Species With Mucin In The Context Of Barrett's Esophagus, Ritisha Suresh
Honors Undergraduate Theses
Gastroesophageal Reflux Disease (GERD) can progress to the precancerous Barrett’s Esophagus (BE) condition, in which the normal esophageal squamous epithelium is replaced with a columnar epithelium containing goblet cells. Mucins, sticky substances, are secreted in response to bile acid exposure during reflux episodes to protect the esophageal epithelium. Goblet cells secrete these mucins, which can also scaffold microbial colonization. Probiotic Lactobacillus bacteria can use glycosidase enzymes to process mucin and metabolize them into their component sugars (glycans). This project aims to identify the role of the Lactobacillus-mucin interaction in BE, as glycan availability could confer an advantage to Lactobacillus …