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Full-Text Articles in Entire DC Network
Elucidating The Molecular Pathway Of Atypical Plasmodium Falciparum Kinases Through Substrate Characterization, Daniel Segarra
Elucidating The Molecular Pathway Of Atypical Plasmodium Falciparum Kinases Through Substrate Characterization, Daniel Segarra
HIM 1990-2015
Plasmodium falciparum, the organism responsible for the most prevalent and most virulent cases of malaria in humans, poses a major burden to the developing world. The parasite is increasingly developing resistance to traditional therapies, such as chloroquine, so the need to determine novel drug targets is more prevalent than ever. One such method involves targeting proteins unique to the malarial proteome that do not have homologues in humans. An especially promising group of targets are protein kinases, which are involved in many different biochemical pathways within the cell. Eukaryotic cell cycle progression is moderated by a family of protein kinases …
The Innovator, Volume 3 Issue 6, Winter 2014-2015, Christa Santos
The Innovator, Volume 3 Issue 6, Winter 2014-2015, Christa Santos
The Innovator
No abstract provided.
University Of Central Florida Factbook 2014-2015, University Of Central Florida
University Of Central Florida Factbook 2014-2015, University Of Central Florida
Historical Fact Book and Enrollment
Historical fact book and enrollment data for the University of Central Florida.
College Of American Pathologists' Laboratory Standards For Next-Generation Sequencing Clinical Tests, Nazneed Aziz, Qin Zhao, Lynn Bry, Denise K. Driscoll, Birgit Funke, Jane S. Gibson, Wayne W. Grody, Madhuri R. Hegde, Gerald A. Hoeltge, Debra G. B. Leonard, Jason D. Merker, Rakesh Nagarajan, Linda A. Palicki, Ryan S. Robetorye, Iris Schrijver, Karen E. Weck, Karl V. Voelkerding
College Of American Pathologists' Laboratory Standards For Next-Generation Sequencing Clinical Tests, Nazneed Aziz, Qin Zhao, Lynn Bry, Denise K. Driscoll, Birgit Funke, Jane S. Gibson, Wayne W. Grody, Madhuri R. Hegde, Gerald A. Hoeltge, Debra G. B. Leonard, Jason D. Merker, Rakesh Nagarajan, Linda A. Palicki, Ryan S. Robetorye, Iris Schrijver, Karen E. Weck, Karl V. Voelkerding
Faculty Bibliography 2010s
Context.-The higher throughput and lower per-base cost of next-generation sequencing (NGS) as compared to Sanger sequencing has led to its rapid adoption in clinical testing. The number of laboratories offering NGS-based tests has also grown considerably in the past few years, despite the fact that specific Clinical Laboratory Improvement Amendments of 1988/College of American Pathologists (CAP) laboratory standards had not yet been developed to regulate this technology. Objective.-To develop a checklist for clinical testing using NGS technology that sets standards for the analytic wet bench process and for bioinformatics or '' dry bench'' analyses. As NGS-based clinical tests are new …
The Platform Trial An Efficient Strategy For Evaluating Multiple Treatments, Scott M. Berry, Jason T. Connor, Roger J. Lewis
The Platform Trial An Efficient Strategy For Evaluating Multiple Treatments, Scott M. Berry, Jason T. Connor, Roger J. Lewis
Faculty Bibliography 2010s
No abstract provided.
Temperament And Child Maltreatment: A Closer Look At The Interactions Among Mother And Child Temperament, Stress And Coping, Emotional And Behavioral Regulation, And Child Maltreatment Potential, Amanda Lowell
Electronic Theses and Dissertations
Several theoretical risk models were proposed previously regarding the prediction of child maltreatment. Although child maltreatment was predicted individually in these models by such variables as parent temperament, emotional and behavioral regulation, stress, coping, and child temperament, these variables were not yet examined collectively. As such, a new transactional theory was proposed for the current study. As part of this study, a national community sample of 158 culturally diverse mothers of young children who were between the ages of 1½- to 5-years rated their own temperament, emotional and behavioral regulation abilities, parenting stress, daily hassles, and coping behaviors as well …
The Perceived Effectiveness Of Mixed Reality Experiences In A Master Of Arts In Teaching (Mat) Program For Science, Technology, Engineering, And Mathematics Degreed Individuals, Chana Speir
Electronic Theses and Dissertations
The purpose of this study was to examine the perceived effectiveness of mixed reality experiences on resident teachers who successfully completed an undergraduate Science, Technology, Engineering, or Mathematics (STEM) degree and were enrolled in a Master of Arts in Teaching (MAT) degree program as part of RTP3 at a large research university in Orlando, Florida. The population for this study consisted of those selected to be in the RTP3, which included being in the Masters in the Art of Teaching (MAT) and becoming a middle or high school science, mathematics, or engineering teacher. The resident teachers experienced mixed reality as …
Treatment Matching In Ptsd: A Confirmatory Factor Analysis Based On Therapeutic Mechanisms Of Action, Benjamin Trachik
Treatment Matching In Ptsd: A Confirmatory Factor Analysis Based On Therapeutic Mechanisms Of Action, Benjamin Trachik
Electronic Theses and Dissertations
The current study takes an initial step toward deriving a method for empirically based, theory-driven treatment matching in a military population suffering from PTSD. Along with the more overt symptoms of PTSD (e.g., persistent hyperarousal), secondary cognitive symptoms have also been shown to be significantly associated with avoidance and intrusive symptoms, as well as contribute to functional impairment. Based on the factor analytic and treatment literature for PTSD, it appears that there are two central mechanisms associated with beneficial therapeutic change that underlies both CPT and PE treatments (i.e., habituation, changes in cognitions). Additionally, different traumatic events and peritraumatic responses …
Affective And Autonomic Responses To Erotic Images Among Young Women With And Without Sexual Difficulties, Natasha De Pesa
Affective And Autonomic Responses To Erotic Images Among Young Women With And Without Sexual Difficulties, Natasha De Pesa
Electronic Theses and Dissertations
Existing models of female sexual dysfunction (FSD) are broad and do not provide information about how to improve existing interventions. The purpose of the current study is to extend the empirical application of a disgust model of FSD (de Jong, van Overveld, & Borg, 2013) to a population of young women reporting difficulties with sexual desire and/or arousal and related distress. Sixty college-aged females participated in the study and were placed into two groups based upon their reports of sexual functioning and sexual distress: a control group (i.e., no sexual difficulties or distress) and a clinical group (i.e., difficulties with …
Intramuscular Anabolic Signaling And Endocrine Response Following Different Resistance Exercise Protocols In Trained Men, Adam Gonzalez
Intramuscular Anabolic Signaling And Endocrine Response Following Different Resistance Exercise Protocols In Trained Men, Adam Gonzalez
Electronic Theses and Dissertations
The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway appears to be the primary regulator of protein synthesis and growth. While resistance exercise paradigms are often divided into hypertrophy (HYP) and strength (STR) protocols, it is unknown whether these protocols differentially stimulate mTORC1 signaling. The purpose of this study was to examine mTORC1 signaling in conjunction with circulating hormone concentrations following a typical lower-body HYP and STR resistance exercise protocol. Ten resistance-trained men (24.7±3.4y; 90.1±11.3kg; 176.0±4.9cm) performed each resistance exercise protocol in a random, counterbalanced order. Blood samples were obtained at baseline (BL), immediately (IP), 30 minutes (30P), 1 …
Women And Time: Food Work Politics Of Self Defined Healthy Men, Juan Barredo
Women And Time: Food Work Politics Of Self Defined Healthy Men, Juan Barredo
Electronic Theses and Dissertations
This study examined the way gender operates in relation to time within the food work spectrum discussed in 19 narratives. The 19 narratives came from individual open ended face-to-face interviews with self-defined healthy men who shop at healthy food stores. This study's examination of how gender operates in the narratives was based on how the men constructed their experiences with women and work in relation to time through the food work spectrum. Women mentioned in the sampled narratives taught the men how to shop and eat in a healthy manner but women still did the cooking. Work wise the findings …
An Evaluation Of The Terms And Conditions Of Appointed County School Superintendents Contracts In The State Of Florida And The Correlation Between District Size And Superintendent Salary, Steven Soules
Electronic Theses and Dissertations
The purpose of this study was to provide an in-depth examination of the terms and conditions found in the employment contracts of Florida Appointed School District Superintendents, with a secondary focus on salary and termination without cause. Employment contracts were obtained from each of the 26 school districts with appointed school superintendents, and then carefully analyzed for similarities and differences. The results of this study will provide Florida school districts with information to construct the best possible employment contracts to both attract top talent and protect the interests of the school district.
Phenomenological Study Of Urban Elementary Principals: Reading-Proficient Students With Learning Disabilities, Elizabeth Theis
Phenomenological Study Of Urban Elementary Principals: Reading-Proficient Students With Learning Disabilities, Elizabeth Theis
Electronic Theses and Dissertations
Changes in the demands on educational leaders have necessitated shifts in the roles and responsibilities of school principals. Meeting the needs of students with disabilities is among the critical challenges that administrators face today. The purpose of this study was to examine the lived experiences of elementary school principals where students with Specific Learning Disabilities (SLD) demonstrate reading proficiency. Phenomenological research was conducted to identify the themes associated with effective school leadership, related to this specific population, students with SLD. Informal, non evaluative observations were conducted in conjunction with analysis of leadership summaries that were submitted by teachers who were …
Modeling Autocorrelation And Sample Weights In Panel Data: A Monte Carlo Simulation Study, Parul Acharya
Modeling Autocorrelation And Sample Weights In Panel Data: A Monte Carlo Simulation Study, Parul Acharya
Electronic Theses and Dissertations
This dissertation investigates the interactive or joint influence of autocorrelative processes (autoregressive-AR, moving average-MA, and autoregressive moving average-ARMA) and sample weights present in a longitudinal panel data set. Specifically, to what extent are the sample estimates influenced when autocorrelation (which is usually present in a panel data having correlated observations and errors) and sample weights (complex sample design feature used in longitudinal data having multi-stage sampling design) are modeled versus when they are not modeled or either one of them is taken into account. The current study utilized a Monte Carlo simulation design to vary the type and magnitude of …
A Binary Approach For Selective Recognition Of Nucleic Acids And Proteins, Evan Cornett
A Binary Approach For Selective Recognition Of Nucleic Acids And Proteins, Evan Cornett
Electronic Theses and Dissertations
The design of probes for the selective recognition of biopolymers (nucleic acids and proteins) is a fundamental task for studying, diagnosing, and treating diseases. Traditional methods utilize a single component (small molecule or oligonucleotide) that binds directly to the target biopolymer. However, many biopolymers are unable to be targeted with this approach. The overarching goal of this dissertation is to explore a new, binary approach for designing probes. The binary approach requires two components that cooperatively bind to the target, triggering a recognition event. The requisite binding of two-components allows the probes to have excellent selectivity and modularity. The binary …
A Phenomenological Investigation Of The Lived Experiences Of African American Adults In Individual Mental Health Counseling, Jessica Martin
A Phenomenological Investigation Of The Lived Experiences Of African American Adults In Individual Mental Health Counseling, Jessica Martin
Electronic Theses and Dissertations
African Americans continue to access non-emergency mental health care at a lower rate than White Americans, despite have equal risk for mental health issues. Currently, literature in counseling focuses on this deficit and why African Americans do not attend counseling, as opposed to those African Americans who do choose to go into counseling. The purpose of this heuristic phenomenological study was to investigate the lived experiences of adult African American mental health counseling clients. Two types of purposive sampling, criterion and snowball, were used to identify and recruit participants. Six African American women were selected for inclusion in this study. …
The Effect Of Precipitation On The Spread Of Mosquito-Borne Diseases: A Case Study Of Florida Counties, Marvin Osbourne
The Effect Of Precipitation On The Spread Of Mosquito-Borne Diseases: A Case Study Of Florida Counties, Marvin Osbourne
Electronic Theses and Dissertations
The state of Florida is the third most populous state in the United States of America, with six (6) of its metropolitan areas dubbed as the fastest growing in the entire country. A mosquito bite may mean the transmission of a virus or disease which might be fatal. Hence, there is a need for the state to control mosquitoes through the various Departments of Mosquito Control in each of its sixty-seven (67) counties. Six locally acquired mosquito-borne viruses which affect humans and animals in the state of Florida were considered. This thesis used statistical methods to examine data for rainfall, …
Boundaries: The Relationships Among Family Structure, Identity Style, And Psychopathology, Kaylin Ratner
Boundaries: The Relationships Among Family Structure, Identity Style, And Psychopathology, Kaylin Ratner
Electronic Theses and Dissertations
Research has long held that family of origin plays a significant, if not critical, role in mental health. The purpose of the present study was to provide theoretical evidence to support the feasibility of a new target for clinical intervention by demonstrating that identity style, the way individuals take in and process identity-relevant information, is a mediating factor between family cohesion and psychopathology. Secondly, this study aimed to provide empirical evidence for identity boundaries, or the cognitive barrier that dictates the assimilation and disposal of identity-relevant information, by linking identity style to one*s ability to differentiate the self from others. …
Les Temps Roulent: An Analysis Of Emergency Medical And Police Response Times To Shootings And Lethality In New Orleans, Sarah Sacra
Electronic Theses and Dissertations
Lethality of aggravated assaults has long been discussed in terms of weapons used, location of assault, demographics of victims, and regions of the US in which the assault occurred. However, dating back to the 1950s, medical response times have been discussed as a mediating factor, but minimally explored in analyses. The current study assesses the lethality of shootings with a primary focus on emergency medical and police response times in New Orleans, LA. Along with routine activities and social disorganization indicators, 102 shootings that occurred in 3 months are analyzed to establish response time patterns of lethality. Results indicate that …
American Indian Homicide; A County Level Analysis Utilizing Social Disorganization Theory Revisted, Kayla Ward
American Indian Homicide; A County Level Analysis Utilizing Social Disorganization Theory Revisted, Kayla Ward
Electronic Theses and Dissertations
Lanier and Huff-Corzine's (2006) article "American Indian Homicide: A County-Level Analysis Utilizing Social Disorganization Theory" has been referred to as a highly influential piece of literature on American Indian homicide. The study looked at American Indian homicide victimization incidents by county between 1986 and 1992 in the continental United States using the framework of social disorganization theory. Despite the violent crime drop in the 1990s, little research exists that examines current dynamics of American Indian homicide. This study provides an updated replication of Lanier and Huff-Corzine (2006) by examining the impact of social disorganization on American Indian homicide victimization between …
Client Outcome: An Exploratory Investigation Of Multicultural Competence And The Working Alliance, Jessica Gonzalez
Client Outcome: An Exploratory Investigation Of Multicultural Competence And The Working Alliance, Jessica Gonzalez
Electronic Theses and Dissertations
Early termination and low retention of clients is a common problem in counseling, with between 65%-80% of clients terminating treatment before the 10th session (Garfield, 1994; Lambert, 2013). Researchers (Lampropoulous, Schneider, & Spengler, 2009; Owen, Smith, & Rodolfa, 2009) have found that predictors of early termination include client age, race, socioeconomic status, and level of perceived distress. Furthermore, racial and ethnic minorities underutilize mental health services and have low retention when engaged in services, highlighting the need for counseling professionals to empirically explore factors that may be contributing to client engagement of the counseling process. Exploration of multicultural competence and …
Central Florida Educational Leaders' Professional Perceptions Of Race To The Top Components Concerning Teacher Evaluation And Compensation, Orin Smith
Electronic Theses and Dissertations
This mixed-methods replication study was conducted to develop further understanding of the professional perceptions of educational leaders as to the fairness and impact of Race to the Top reforms concerning teacher evaluation and compensation on student achievement and growth. Graduate students in education and educational leadership from a target university were selected to complete an electronic survey to collect quantitative and qualitative data for analysis. Quantitative results from the electronic survey revealed limited diversity in professional perceptions of the five identified components of RTTT based upon professional classification or percentage free and reduced lunch population at the school sites where …
Acute Pro-Inflammatory Immune Response Following Different Resistance Exercise Protocols In Trained Men, Adam Wells
Acute Pro-Inflammatory Immune Response Following Different Resistance Exercise Protocols In Trained Men, Adam Wells
Electronic Theses and Dissertations
The successful regeneration of muscle tissue is dependent upon the infiltration of phagocytic CD14++CD16- monocytes that support the proliferation and differentiation of myogenic precursor cells. Physiologically, the magnitude of the cellular response following resistance exercise is dictated by the level of receptor expression on the plasma membrane of the monocyte, as well as the secretion of their cognate ligands from tissue resident cells. However, it remains unclear whether the innate pro-inflammatory immune response varies with different resistance training protocols, and how it may impact recovery and the muscle remodeling process. Therefore, the purpose of this investigation was to examine temporal …
Exploring Leadership Experiences Of School Psychologists In Supporting Schools: A Phenomenological Study, Julie Joseph
Exploring Leadership Experiences Of School Psychologists In Supporting Schools: A Phenomenological Study, Julie Joseph
Electronic Theses and Dissertations
The passage of the No Child Left Behind Act (NCLB) and the reauthorization of the Individuals with Disabilities Education Act in 2004 have placed increased demands on all educators and administrators. School psychologists find themselves charged with addressing a broad range of issues today, and there is an emphasis on leadership in the effective provision of services. Although the literature is replete with examples of the centrality of leadership in regards to the educational experience of students, there have not been sufficient studies that have studied this topic in school psychology. The purpose of this study was to discover, understand, …
The Impact Of Video Modeling Combined With Skillstreaming Teaching Procedures On The Social Interaction Skills Of Middle School Aged Students With Autism Spectrum Disorders, Onur Kocaoz
Electronic Theses and Dissertations
This purpose of this study was to investigate the effectiveness of an intervention package that combined Skillstreaming procedures for the development of social skills with the use of video modeling for middle school students identified with ASD. Specifically, the purpose of this study was to determine if the video modeling intervention package has an impact on social skill performance of three middle school-aged students with ASD. A multiple probe design across participants was employed to assess the effects of the video modeling intervention package on two beginning social skills (i.e., initiate greetings and initiate a conversation). The participants were three …
Friendship And Informant Characteristics Associated With Agreement Among Adolescent And Friend Ratings Of Behavior Problems., Brea-Anne Lauer
Friendship And Informant Characteristics Associated With Agreement Among Adolescent And Friend Ratings Of Behavior Problems., Brea-Anne Lauer
Electronic Theses and Dissertations
Although teacher and parent informants often are used to gather information regarding adolescents* emotional and behavioral functioning, research has suggested that agreement among these raters and adolescents* self-ratings tends to be low to moderate. Given that friends typically play an important role in the lives of adolescents, the present study sought to determine the relative agreement amongst adolescent self-reports and those of their friends as well as factors that might impact this agreement. In particular, a sample of 207 culturally diverse high school students were matched based on perceived friendship closeness and asked to provide ratings of their own emotional …
The Effect Of Pre-Service Teaching On Student Achievement Using A Co-Teaching Model At An Elementary School In A Large, Urban School District In Central Florida, Walton Mchale
Electronic Theses and Dissertations
This study was focused on the effect of pre-service teaching utilizing a co-teaching model on student achievement at an elementary school in a large, urban school district in central Florida. The contribution of university student teachers (i.e., interns) to elementary school achievement was investigated. Specifically explored was the difference between student achievement scores in classes with interns who participated in a co-teaching model and interns in classes that did not employ any structured approach to intern teaching. The researcher compared seven classes that employed co-teaching, where the university intern teacher and master teacher remained in the class conducting instruction, to …
A Case Study Evaluation Of Quality Standards And Online Faculty Development, Erin O'Brien
A Case Study Evaluation Of Quality Standards And Online Faculty Development, Erin O'Brien
Electronic Theses and Dissertations
This dissertation in practice was designed to provide an evaluation case study of two institutions, one college and one university, in the field of online learning and quality assurance. The writer evaluated these two institutions of higher learning to discover what online teaching criteria are required and what quality assurance processes are being used to assess the quality of the institutions* online courses. An analysis of the data revealed that both institutions were at the appropriate stage of development, support, training and quality assurance measures for their sizes, online populations and for the length of time they have been involved …
An Evaluation Of A New Course Modality: A Pilot Study Of Cross-Listed Courses At Devry University, Karol Sapijaszko
An Evaluation Of A New Course Modality: A Pilot Study Of Cross-Listed Courses At Devry University, Karol Sapijaszko
Electronic Theses and Dissertations
Devry University, a private for-profit higher education institution, generates its revenue exclusively by students* tuition. In addition, DeVry University offers courses via two modalities: blended and online. Unfortunately, Devry University has seen its student enrollments decline over the last few years. Because of lower student enrollment levels, DeVry University has had to limit its course offerings. The problem of practice addressed in this dissertation is an insufficient number of blended course offerings for current DeVry students. To remedy this problem, an initiative was started at DeVry University to address the insufficient number of blended course offerings and to pilot a …
Diabetes Phenotypes In Transgenic Pancreatic Cancer Mouse Models, Toya Albury-Warren
Diabetes Phenotypes In Transgenic Pancreatic Cancer Mouse Models, Toya Albury-Warren
Electronic Theses and Dissertations
Protein Kinase B/AKT, a serine/threonine kinase with three isoforms (AKT1-3), is downstream of phosphatidylinositol 3-kinase (PI3K), and signals through the phosphorylation and subsequent activation or inhibition of downstream substrates, such as mammalian target of rapamycin complex 1 (mTORC1) or glycogen synthase kinase 3 beta (GSK-3?), respectively. The AKT1 isoform is predominantly recognized for regulation of cell survival, growth, and proliferation, due to its constitutive activation in pancreatic cancers (e.g., islet cell carcinoma and pancreatic adenocarcinoma). The progression of pancreatic ductal adenocarcinoma (PDAC), the most lethal common cancer, is initiated by activation mutations of the KRas oncogene. This leads to additional …